Acute effects of intravenous infusion of ApoA1/phosphatidylcholine discs on plasma lipoproteins in humans. (1/61)
To investigate the metabolism of nascent HDLs, apoA1/phosphatidylcholine (apoA1/PC) discs were infused IV over 4 hours into 7 healthy men. Plasma total apoA1 and phospholipid (PL) concentrations increased during the infusions. The rise in plasma apoA1 was greatest in small prebeta-migrating particles not present in the infusate. Total HDL unesterified cholesterol (UC) also increased simultaneously. After stopping the infusion, the concentrations of apoA1, PL, HDL UC, and small prebeta HDLs decreased, whereas those of HDL cholesteryl ester (CE) and large alpha-migrating apoA1 containing HDLs increased. ApoB-containing lipoproteins became enriched in CEs. Addition of apoA1/PC discs to whole blood at 37 degrees C in vitro also generated small prebeta HDLs, but did not augment the transfer of UC from erythrocytes to plasma. We conclude that the disc infusions increased the intravascular production of small prebeta HDLs in vivo, and that this was associated with an increase in the efflux and esterification of UC derived from fixed tissues. The extent to which the increase in tissue cholesterol efflux was dependent on that in prebeta HDL production could not be determined. Infusion of discs also reduced the plasma apoB and apoA2 concentrations, and increased plasma triglycerides and apoC3. Thus, nascent HDL secretion may have a significant impact on prebeta HDL production, reverse cholesterol transport and lipoprotein metabolism in humans. (+info)mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis. (2/61)
A 5.9-kb region of the Bacillus subtilis chromosome is transcribed as a single transcript that is predicted to encode seven membrane-spanning proteins. Homologues of the first gene of this operon, for which the designation mrp (multiple resistance and pH adaptation) is proposed here, have been suggested to encode an Na+/H+ antiporter or a K+/H+ antiporter. In the present studies of the B. subtilis mrp operon, both polar and nonpolar mutations in mrpA were generated. Growth of these mutants was completely inhibited by concentrations of added Na+ as low as 0.3 M at pH 7.0 and 0.03 M at pH 8.3; there was no comparable inhibition by added K+. A null mutant that was constructed by full replacement of the mrp operon was even more Na+ sensitive. A double mutant with mutations in both mrpA and the multifunctional antiporter-encoding tetA(L) gene was no more sensitive than the mrpA mutants to Na+, consistent with a major role for mrpA in Na+ resistance. Expression of mrpA from an inducible promoter, upon insertion into the amyE locus, restored significant Na+ resistance in both the polar and nonpolar mrpA mutants but did not restore resistance in the null mutant. The mrpA disruption also resulted in an impairment of cytoplasmic pH regulation upon a sudden shift in external pH from 7.5 to 8.5 in the presence of Na+ and, to some extent, K+ in the range from 10 to 25 mM. By contrast, the mrpA tetA(L) double mutant, like the tetA(L) single mutant, completely lost its capacity for both Na+- and K+-dependent cytoplasmic pH regulation upon this kind of shift at cation concentrations ranging from 10 to 100 mM; thus, tetA(L) has a more pronounced involvement than mrpA in pH regulation. Measurements of Na+ efflux from the wild-type strain, the nonpolar mrpA mutant, and the complemented mutant indicated that inducible expression of mrpA increased the rate of protonophore- and cyanide-sensitive Na+ efflux over that in the wild-type in cells preloaded with 5 mM Na+. The mrpA and null mutants showed no such efflux in that concentration range. This is consistent with MrpA encoding a secondary, proton motive force-energized Na+/H+ antiporter. Studies of a polar mutant that leads to loss of mrpFG and its complementation in trans by mrpF or mrpFG support a role for MrpF as an efflux system for Na+ and cholate. Part of the Na+ efflux capacity of the whole mrp operon products is attributable to mrpF. Neither mrpF nor mrpFG expression in trans enhanced the cholate or Na+ resistance of the null mutant. Thus, one or more other mrp gene products must be present, but not at stoichiometric levels, for stability, assembly, or function of both MrpF and MrpA expressed in trans. Also, phenotypic differences among the mrp mutants suggest that functions in addition to Na+ and cholate resistance and pH homeostasis will be found among the remaining mrp genes. (+info)Substrates of multidrug resistance-associated proteins block the cystic fibrosis transmembrane conductance regulator chloride channel. (3/61)
1. The effects of physiological substrates of multidrug resistance-associated proteins (MRPs) on cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel currents were examined using patch clamp recording from CFTR-transfected mammalian cell lines. 2. Two MRP substrates, taurolithocholate-3-sulphate (TLCS) and beta-estradiol 17-(beta-D-glucuronide) (E217betaG) caused a voltage-dependent block of macroscopic CFTR Cl- currents when applied to the intracellular face of excised membrane patches, with mean apparent dissociation constants (KDs) of 96+/-10 and 563+/-103 microM (at 0 mV) respectively. The unconjugated bile salts taurocholate and cholate were also effective CFTR channel blockers under these conditions, with KDs of 453+/-44 and 3760+/-710 microM (at 0 mV) respectively. 3. Reducing the extracellular Cl- concentration from 154 to 20 mM decreased the KD for block intracellular TLCS to 54+/-1 microM, and also significantly reduced the voltage dependence of block, by suggesting that TLCS blocks Cl- permeation through CFTR by binding within the channel pore. 4. Intracellular TLCS reduced the apparent amplitude of CFTR single channel currents, suggesting that the duration of block is very fast compared to the gating of the channel. 5. The apparent affinity of block by TLCs is comparable to that of other well-known CFTR channel blockers, suggesting that MRP substrates may comprise a novel class of probes of the CFTR channel pore. 6. These results also suggest that the related proteins CFTR and MRP may share a structurally similar anion binding site at the cytoplasmic face of the membrane. (+info)Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives. (4/61)
Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth. (+info)Uptake of bromosulfophthalein via SO2-4/OH- exchange increases the K+ conductance of rat hepatocytes. (5/61)
In confluent primary cultures of rat hepatocytes, micromolar concentrations of bromosulfophthalein (BSP) lead to a sizeable hyperpolarization of membrane voltage. The effect is a saturable function of BSP concentration yielding an apparent value of 226 micromol/l and a Vmax of -10.3 mV. The BSP-induced membrane hyperpolarization is inhibited by the K+ channel blocker Ba2+, and in cable-analysis and ion-substitution experiments it becomes evident that the effect is due to a significant increase in cell membrane K+ conductance. Voltage changes were attenuated by the simultaneous administration of SO2-4, succinate, and cholate (cis-inhibition) and increased after preincubation with SO2-4 and succinate (trans-stimulation), suggesting that the effect occurs via BSP uptake through the known SO2-4/OH- exchanger. Microfluorometric measurements reveal that BSP-induced activation of K+ conductance is not mediated by changes in cell pH, cell Ca2+, or cell volume. It is concluded that K+ channel activation by BSP (as well as by DIDS and indocyanine green) may reflect a physiological mechanism linking the sinusoidal uptake of certain anions to their electrogenic canalicular secretion. (+info)Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. (6/61)
Past studies of atherosclerosis in mice have used chow-based diets supplemented with cholesterol, lipid, and sodium cholate to overcome species resistance to lesion formation. Similar diets have been routinely used in studies with LDL receptor-deficient (LDLR(-/-)) mice. The nonphysiological nature and potential toxicity of cholate-containing diets have led to speculation that atherogenesis in these mice may not accurately reflect the human disease process. We have designed a semipurified AIN-76A-based diet that can be fed in powdered, pelleted, or liquid form and manipulated for the precise evaluation of diet-genetic interactions in murine atherosclerosis. LDLR(-/-) mice were randomly assigned among 4 diets (n=6/diet) as follows: 1, control, 10% kcal lipid; 2, high fat (40% kcal), moderate cholesterol (0.5% by weight); 3, high fat, high cholesterol (1.25% by weight); and 4, high fat, high cholesterol, and 0.5% (wt/wt) sodium cholate. Fasting serum cholesterol was increased in all cholesterol-supplemented mice compared with controls after 6 or 12 weeks of feeding (P<0.01). The total area of oil red O-stained atherosclerotic lesions was determined from digitally scanned photographs. In contrast to the control group, all mice in cholesterol-supplemented dietary groups 2 to 4 had lesions involving 7.01% to 12.79% area of the thoracic and abdominal aorta at 12 weeks (P<0.002, for each group versus control). The distribution pattern of atherosclerotic lesions was highly reproducible and comparable. The histological features of lesions in mice fed cholate-free or cholate-containing diets were similar. This study shows that sodium cholate is not necessary for the formation of atherosclerosis in LDLR(-/-) mice and that precisely defined semipurified diets are a valuable tool for the examination of diet-gene interactions. (+info)Alterations in detergent solubility of heterotrimeric G proteins after chronic activation of G(i/o)-coupled receptors: changes in detergent solubility are in correlation with onset of adenylyl cyclase superactivation. (7/61)
Prolonged G(i/o) protein-coupled receptor activation has been shown to lead to receptor internalization and receptor desensitization. In addition, it is well established that although acute activation of these receptors leads to inhibition of adenylyl cyclase (AC), long-term activation results in increased AC activity (especially evident on removal of the inhibitory agonist), a phenomenon defined as AC superactivation or sensitization. Herein, we show that chronic exposure to agonists of G(i)-coupled receptors also leads to a decrease in cholate detergent solubility of G protein subunits, and that antagonist treatment after such chronic agonist exposure leads to a time-dependent reversal of the cholate insolubility. With Chinese hamster ovary and COS cells transfected with several G(i/o)-coupled receptors (i.e., mu- and kappa-opioid, and m(4)-muscarinic), we observed that although no overall change occurred in total content of G(alphai)- and beta(1)-subunits, chronic agonist treatment led to a marked reduction in the ability of 1% cholate to solubilize G(betagamma) as well as G(alphai). This solubility shift is exclusively observed with G(alphai), and was not seen with G(alphas). The disappearance and reappearance of G(alphai) and G(betagamma) subunits from and to the detergent-soluble fractions occur with similar time courses as observed for the onset and disappearance of AC superactivation. Lastly, pertussis toxin, which blocks acute and chronic agonist-induced AC inhibition and superactivation, also blocks the shift in detergent solubility. These results suggest a correlation between the solubility shift of the heterotrimeric G(i) protein and the generation of AC superactivation. (+info)Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes. (8/61)
A difficult problem concerning the interaction of DNA with amphiphiles of opposite charge above their critical micelle concentration is the propensity for aggregation of the condensed DNA complexes. In this study, this problem was addressed by attenuating amphiphile charge density within a cholate micelle environment. The amphiphile consisted of a cationic peptide, acetyl-CWKKKPKK-amide, conjugated to dilaurylphos-phatidylethanolamine. In the presence of cholate, multiple equivalents of cationic charge were required to bring about the completion of DNA condensation. At the end point of condensation, stable, soluble DNA-micelle complexes were formed, which by dynamic light scattering exhibited apparent hydro-dynamic diameters between 30 and 60 nm. Aggregation, as measured by static light scattering at 90 degrees and by turbidity, was not observed until further additions of peptide-lipid conjugate were made beyond the end point of DNA condensation. Liposome complexes containing the non-aggregated, compacted DNA were formed by adding dioleoylphosphatidylcholine followed by removing the cholate by dialysis. The resulting complexes were distributed within a narrow density range, the DNA was quantitatively assembled into the liposomes, and liposomes without DNA were not detected. Small particles were formed with a mean hydrodynamic diameter of 77 nm. The liposomal DNA showed complete retention of its supercoiled form and no detectable sensitivity to DNase (25 U/10 microg DNA, 1.5 h, 37 degrees C). The use of an anionic, dialyzable amphiphile to attenuate charge inter-actions between DNA and cationic amphiphiles is a useful technology for the quantitative assembly of compacted DNA into conventional liposomes, with complete protection against nuclease activity. (+info)
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Gabriel Kreuther
"Americas Bean-to-Bar and Chocolatier Competition Winners 2019". International Cholate Awards. 26 June 2019. Cuozzo, Steve (19 ...
Cholic acid
Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids ...
Janet Scott (scientist)
Scott, Janet Lesley (1995). Inclusion compounds of cholic acid and methyl cholate (Thesis). Place of publication not identified ... Her doctoral research considered cholic acid and methyl cholate. Scott joined the faculty at the University of Cape Town in ...
Cholestasis
Cholate statis is more common in obstructive cholestasis compared to non-obstructive cholestasis. During the cholate statis ... Cholestasis is often marked by cholate statis, which are a set of changes that occur in the periportal hepatocytes. ...
Monovalent cation:proton antiporter-3
YufF (MrpF) appears to catalyze cholate efflux, possibly by a Na+ symport mechanism. It plays a major role in Na+ extrusion and ... multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis". Journal of ... and alkali but not cholate resistance". Journal of Bacteriology. 182 (20): 5663-70. doi:10.1128/jb.182.20.5663-5670.2000. PMC ...
Spermicide
The spermicides benzalkonium chloride and sodium cholate are used in some contraceptive sponges. Benzalkonium chloride might ...
5-HT3 antagonist
"Enantioseparation of palonosetron hydrochloride by micellar electrokinetic chromatography with sodium cholate as chiral ...
SLC27A5
"The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J Biol Chem. 275 (21): 15605-8 ...
COQ2
"Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1- ...
Photolabile protecting group
"A Study of the Photochemical Response of o-Nitrobenzyl Cholate Derivatives in P(MMA-MAA) Matrices". Journal of Polymer Science ...
SLC27A6
2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J. Biol. Chem. 275 (21 ...
Contact lens
"The effect of octylglucoside and sodium cholate in Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to soft ...
Octyl glucoside
"The effect of octylglucoside and sodium cholate in Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to soft ...
Molybdenum ditelluride
The sheets in α-MoTe2 can be separated and dispersed in water with a sodium cholate surfactant and sonication. It forms an ...
Estradiol 3-glucuronide 17β-sulfate
... dehydroepiandrosterone and their glucuronide and sulfate conjugates in serum using sodium cholate micelle capillary ...
Mass concentration (chemistry)
... cholate solution, 0.1 grams of cholate are dissolved in 10 mL of water. Volumetric flasks are the most appropriate piece of ...
ABCB11
This particular protein is responsible for the transport of taurocholate and other cholate conjugates from hepatocytes (liver ...
Liver biopsy
The best of these were the perfused hepatic mass (PHM) by quantitative laparoscopic liver spleen scan (QLSS) and oral Cholate ...
List of MeSH codes (D04)
... cholates MeSH D04.808.105.225.130.330.850 - sodium cholate MeSH D04.808.105.225.261 - dehydrocholic acid MeSH D04.808.105.225. ... cholates MeSH D04.808.221.430.130.330.850 - sodium cholate MeSH D04.808.221.430.265 - dehydrocholic acid MeSH D04.808.221.430. ...
Bile-acid 7alpha-dehydroxylase
... (EC 1.17.99.5, cholate 7alpha-dehydroxylase, 7alpha-dehydroxylase, bile acid 7-dehydroxylase) ...
Solute carrier organic anion transporter family member 1B3
CDCA-NBD Cholate (CA) Cholecystokinin octapeptide (CCK-8) Dehydroepiandroserone-3-sulfate (DHEAS) Deltorphin II ...
List of EC numbers (EC 6)
... cholate-CoA ligase EC 6.2.1.8: oxalate-CoA ligase EC 6.2.1.9: malate-CoA ligase EC 6.2.1.10: carboxylic acid-CoA ligase (GDP- ... cholate-CoA ligase EC 6.2.1.30: phenylacetate-CoA ligase EC 6.2.1.31: 2-furoate-CoA ligase EC 6.2.1.32: anthranilate-CoA ligase ...
List of enzymes
Cholate-CoA ligase EC 6.2.1.8: Oxalate-CoA ligase EC 6.2.1.9: Malate-CoA ligase EC 6.2.1.10: Acid-CoA ligase (GDP-forming) EC ...
Decellularization of porcine heart valve
Chemical treatments- anionic detergent: (Sodium dodecyl sulfate (SDS)), sodium cholate, enzymatic agent (Trypsin), non-ionic ...
Choloyl-CoA hydrolase
... cholate + CoA This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic ...
BAL
Cholate-CoA ligase, an enzyme Pennsylvania Station (Baltimore), Maryland, US, station code The US city of Baltimore, Maryland ...
Organo anion transporter family
... taurocholate and cholate), steroid conjugates, thyroid hormones, anionic oligopeptides, drugs, toxins and other xenobiotics. ...
Thiosulfate-citrate-bile salts-sucrose agar
... which is a naturally occurring substance containing a mixture of bile salts and sodium cholate, a pure bile salt. Sodium ... liter Yeast extract 5.0 g Proteose Peptone 10.0 g Sodium thiosulfate 10.0 g Sodium citrate 10.0 g Ox gall 5.0 g Sodium cholate ...
Cholate-CoA ligase
... (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl ... Cholate---CoA+ligase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 6.2.1). ... is an enzyme with systematic name cholate:CoA ligase (AMP-forming). This enzyme catalyses the following chemical reaction (1) ... ATP + cholate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + choloyl-CoA (2) ATP + (25R)-3alpha,7alpha,12alpha ...
Ligase - Wikipédia
EC 6.2.1.6 glutarate-CoA ligase EC 6.2.1.7 cholate-CoA ligase EC 6.2.1.8 oxalate-CoA ligase EC 6.2.1.9 malate-CoA ligase EC 6.2 ...
Definitions of cholate - OneLook Dictionary Search
cholate: Collins English Dictionary [home, info] *cholate: Wordnik [home, info] *cholate: Wiktionary [home, info] *cholate: ... cholate: Free Dictionary [home, info] *cholate: Dictionary/thesaurus [home, info] Computing (1 matching dictionary). *cholate: ... cholate: Dictionary.com [home, info] *Cholate: Wikipedia, the Free Encyclopedia [home, info] *Cholate: Online Plain Text ... cholate: Medical dictionary [home, info] Quick definitions from Wiktionary (cholate). ▸ noun: (organic chemistry) Any salt or ...
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Glycol-3α-6-keto-5β-cholate. Glycol3α6keto-5β-cholate. OH (α). =O. H. OH (α). NHCH2COO−. ... GDC: Glycodeoxychoate; NaTC: sodium taurocholate; NaC: sodium cholate; NaLC: sodium lithocholate; NaGC: sodium glycocholate; ... Sodium cholate is present in the RapidMist™ spray that is used for delivery of insulin to the buccal mucosa [84]. Regarding the ... The effect of cholate type, particle size and administered dose. Eur. J. Pharm. Biopharm. 2012, 81, 265-272. [Google Scholar] [ ...
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Deoxycholate6
- Also catalyzes bile salt:H + antiport, and binds cholate and deoxycholate to the protein with micromolar affinity. (tcdb.org)
- In humans, secondary bile salts are deoxycholate (DOC, from cholate) and litocholate (from chenodeoxycholate) ( 4 , 5 ). (frontiersin.org)
- Small angle neutron scattering (SANS) measurements of D 2 O solutions (0.1 M) of sodium cholate (NaC) and sodium deoxycholate (NaDC) were carried out at T= 298 K. Under compositions very much above the critical micelle concentration (CMC), the bile salt micelle size growths were monitored by adopting Hayter-Penfold type analysis of the scattering data. (ias.ac.in)
- Within the intestines the primary bile acids are acted upon by bacteria and converted to the secondary bile acids, identified as deoxycholate (from cholate) and lithocholate (from chenodeoxycholate). (digitalnaturopath.com)
- Cholate, chenodeoxycholate, deoxycholate and lithocholate · their glycine and taurine conjugates · hydroxylated forms. (yoga-and-ayurveda.com)
- Bile salt is a mixture of two salts namely sodium cholate and sodium deoxycholate and is widely utilized for microbiological applications. (alpha-chemika.com)
Chenodeoxycholate4
- Variations in the pool of primary bile salts occur among vertebrates: for instance, in humans and rats, the primary bile salts are cholate and chenodeoxycholate while in mice they are cholate and muricholate ( 2 ). (frontiersin.org)
- Significant decreases in the proportions of chenodeoxycholate and cholate resulted. (elsevier.com)
- Studies of bile salts on spore germination have shown that chenodeoxycholate, ursodeoxycholate and lithocholate are more potent inhibitors of germination compared to cholate. (unlv.edu)
- Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate). (nih.gov)
Ligase1
- En biochimie , une ligase est une enzyme qui catalyse la jonction de deux molécules (en anglais ligation ) par de nouvelles liaisons covalentes avec hydrolyse concomitante de l' ATP ou d'autres molécules similaires. (wikipedia.org)
Taurocholate2
- The bound polyphenols showed better sodium cholate and taurocholate binding than the free form for most varieties. (biomedcentral.com)
- Here we present four crystal structures of the hCE1 glycoprotein in complexes with the following endogenous substrates or substrate analogues: Coenzyme A, the fatty acid palmitate, and the bile acids cholate and taurocholate. (proteopedia.org)
Cholic1
- Cholic acid is a bile acid , a white crystalline substance insoluble in water (soluble in alcohol and acetic acid ), with a melting point of 200-201 °C. Salts of cholic acid are called cholates . (chemeurope.com)
Surfactant1
- Few-layer MoTe 2 nanosheets and nanoparticles can also obtained from molybdenum ditelluride powder by liquid-exfoliation using sodium cholate salt as surfactant. (ossila.com)
Merci3
- Nalle 33 cm sittande och Merci cholates! (flowers4copenhagen.com)
- Bamse 33 cm sittende og Merci cholates! (flowers4turin.com)
- Teddy bear 33 cm duduk dan Merci cholates! (flowers4amsterdam.com)
Cake2
- Also the famous Cholate Melting Cake was a flop. (cruisecritic.com)
- Two large peeses of chicken, a scoop of marrconie and cheese, two large betatos, a slice of pizza, a banana, a enormose peice of cake, a bag of chipes, a salad, two cholate bars and milk. (blubberbuster.com)
Bile salts1
- Non-denaturing detergents can be divided into non-ionic detergents such as Triton X-100, bile salts such as cholate, and zwitterionic detergents such as CHAPS. (thermofisher.com)
Milk3
- That's right, you can easily make cholate curls from milk, white, or dark chocolate. (bhg.com)
- You do get some milk cholate with a sweet finish as described. (mikescigars.com)
- Can i have more cholate milk OH MYYY thankfully they dont think she actually ate more than one if that at all cause we found one wet…UGhhhhh no matter how much you child proof accidents happen know your NOT alone! (livelovesimple.com)
Cholesterol1
- Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. (vuzv.cz)
Valentine's Day2
- Classic Baci Cholate in Special package for Valentine's Day, Limited Available. (etalianfood.com)
- This Valentine's Day weekend enjoy a Cherries and Cholate Lux Facial (50 minutes) for only $65. (newportbeachindy.com)
Chocolate1
- Adding them before would sometimes burn the cholate and make the chocolate bitter. (myforkinglife.com)
3alpha1
- This enzyme catalyses the following chemical reaction (1) ATP + cholate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + choloyl-CoA (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA This enzyme requires Mg2+ for activity. (wikipedia.org)
Primary bile1
- HST6N-1 mRNA levels were reduced ~80% by treatment (≤24 h) with DOC or TPA but not by cholate, a primary bile acid. (arizona.edu)
Pussy3
- Sexy cholate hoe suck pussy 80 years horny women or casual hook-ups if you. (papercreationsmag.com)
- Ft. Wayne area cholate beach Guam people girls pussy stills of village nude girls wedding party accidental. (haspersonalsweb.com)
- Coppell TX asian massage parlor Ecru MS do horny women go in vegas ber frre pussy en Perry FL gentel sex with very. (makingyourvoicecount.com)
Membranes1
- The βγ-agarose was also used to isolate mixtures of α subunits from cholate extracts of membranes from different bovine tissues. (unthsc.edu)
Sauce1
- The specialities are hand-dived scallops with horseradish, grouse 'en crepinette' with celeriac, blackberry and sauce grand veneur and a cholate, praline and tonka bean dessert. (theirishroadtrip.com)
Bottle1
- You can ask the limo company to add an extra bottle of wine or cholates, or maybe your favorite beer in the cans, just add it up on the list. (shiftedmag.com)
Interaction1
- IMSEAR at SEARO: Interaction of sodium cholate with multilamellar liposomes & the properties of cholate vesicles. (who.int)
Charlie1
- I loved Charlie and the Cholate factory, too. (blogspot.com)
Likes1
- Prince George VA escort female Oviedo Florida women who likes to fucj Baytown cholate. (atelierdesvignoles.com)
Drinks1
- It would be a great for parties, like a birthday cholate for the kids' drinks! (crackerjackcollectors.com)
Vanilla2
- Frosted with either vanilla or cholate buttercream frosting. (eatmecakery.com)
- Slim - Fast Smoothies Cappuccino Smoothie 1 heaping scoop Slim -Fast Optima Frence Vanilla Shake Mix ( I have also used Cholate Royale ) 1 cup â ¦ Select locations now offer curbside pickup & home delivery Indulge with this delicious Vanilla Pomegranate Smoothie blended with pomegranate yogurt to deliver you 21g of protein in a refreshing and creamy. (processmuseum.org)
Sweet3
- ???????? ???? ?????? ??? ????????????? ??? ?????, ?????? ???? ???????, ????? ???? , ??? Cholate Greedy Sweet - Gourmand ?????? ????????? ???. (shaik-vip.ru)
- I just realized I should have dipped the sweet potato fries in the cholate fountain! (sarinadorie.com)
- These sweet Pj's feature a box of cholates on all brown. (landrysinc.com)
Mixture1
- Cover the roll with more of the yolk mixture and finish by dipping it in the cholate pieces. (bergaraturismo.eus)
White1
- Melt the white cholate spread (au bain marie). (thiscityofgold.com)
Bars1
- If used in cold weather candle, water proff matches, dry sand, and cholate bars. (canoetripping.net)
Activity1
- for instance, SDBS (Sodium dodecylbenzenesulfonate) resulted in toxicity and SC (sodium cholate) didn't trigger toxicity.32,33 Learning the result of functionalized MWCNTs by -COOH over the potassium (K+) stations (Ito, IK, IK1) demonstrated that MWCNTs suppress the K+ stations activity. (chenglilab.org)
Brown1
- It may not be the best combination but serves to tone down the cholate brown and the final light yellow is very effective. (rollaone.com)
Found1
- beta-D-galactosyl-cholate = 1 reactions were found. (tu-bs.de)
Light1
- The Sodium Cholate market research report puts light on the supreme competitors and provides a worms eye view about their market share, trends and market scenarios during the forecast period. (rubixmarketresearch.com)
Effective1
- By contrast, cholestyramine was effective only in cholate sorption. (vuzv.cz)
Final1
- The final focus included 4?M MSP1D1, 400?M POPC, and 25?mM sodium cholate in Buffer A. In every, 500?L of the MSP1D1-(POPC) combine was put into the dry out resin bound with PA organic30. (angiogenesis-blog.com)