Salts and esters of CHOLIC ACID.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A trihydroxy bile salt that is used as a digestive aid in dietary supplements. It is used in culture media and in conjunction with PAPAIN and PANCREATIN.
Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
A species of gram-negative, aerobic rods formerly called Pseudomonas testosteroni. It is differentiated from other Comamonas species by its ability to assimilate testosterone and to utilize phenylacetate or maleate as carbon sources.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Steroids in which fission of one or more ring structures and concomitant addition of a hydrogen atom at each terminal group has occurred.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
Single membrane vesicles, generally made of PHOSPHOLIPIDS.
A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.
Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Cyclic compounds with a ring size of approximately 1-4 dozen atoms.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
Small holes of nanometer dimensions in a membrane, that can be used as single molecule detectors. The pores can be biological or synthetic.
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.
Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.
A receptor protein that is associated with RECEPTOR ACTIVITY-MODIFYING PROTEINS. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 it forms the CALCITONIN GENE-RELATED RECEPTOR. When bound to RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 it forms the ADRENOMEDULLIN RECEPTOR.
A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Gas lasers with excited dimers (i.e., excimers) as the active medium. The most commonly used are rare gas monohalides (e.g., argon fluoride, xenon chloride). Their principal emission wavelengths are in the ultraviolet range and depend on the monohalide used (e.g., 193 nm for ArF, 308 nm for Xe Cl). These lasers are operated in pulsed and Q-switched modes and used in photoablative decomposition involving actual removal of tissue. (UMDNS, 2005)
Coating with a metal or alloy by electrolysis.
Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.
Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.
Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Acute effects of intravenous infusion of ApoA1/phosphatidylcholine discs on plasma lipoproteins in humans. (1/61)

To investigate the metabolism of nascent HDLs, apoA1/phosphatidylcholine (apoA1/PC) discs were infused IV over 4 hours into 7 healthy men. Plasma total apoA1 and phospholipid (PL) concentrations increased during the infusions. The rise in plasma apoA1 was greatest in small prebeta-migrating particles not present in the infusate. Total HDL unesterified cholesterol (UC) also increased simultaneously. After stopping the infusion, the concentrations of apoA1, PL, HDL UC, and small prebeta HDLs decreased, whereas those of HDL cholesteryl ester (CE) and large alpha-migrating apoA1 containing HDLs increased. ApoB-containing lipoproteins became enriched in CEs. Addition of apoA1/PC discs to whole blood at 37 degrees C in vitro also generated small prebeta HDLs, but did not augment the transfer of UC from erythrocytes to plasma. We conclude that the disc infusions increased the intravascular production of small prebeta HDLs in vivo, and that this was associated with an increase in the efflux and esterification of UC derived from fixed tissues. The extent to which the increase in tissue cholesterol efflux was dependent on that in prebeta HDL production could not be determined. Infusion of discs also reduced the plasma apoB and apoA2 concentrations, and increased plasma triglycerides and apoC3. Thus, nascent HDL secretion may have a significant impact on prebeta HDL production, reverse cholesterol transport and lipoprotein metabolism in humans.  (+info)

mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis. (2/61)

A 5.9-kb region of the Bacillus subtilis chromosome is transcribed as a single transcript that is predicted to encode seven membrane-spanning proteins. Homologues of the first gene of this operon, for which the designation mrp (multiple resistance and pH adaptation) is proposed here, have been suggested to encode an Na+/H+ antiporter or a K+/H+ antiporter. In the present studies of the B. subtilis mrp operon, both polar and nonpolar mutations in mrpA were generated. Growth of these mutants was completely inhibited by concentrations of added Na+ as low as 0.3 M at pH 7.0 and 0.03 M at pH 8.3; there was no comparable inhibition by added K+. A null mutant that was constructed by full replacement of the mrp operon was even more Na+ sensitive. A double mutant with mutations in both mrpA and the multifunctional antiporter-encoding tetA(L) gene was no more sensitive than the mrpA mutants to Na+, consistent with a major role for mrpA in Na+ resistance. Expression of mrpA from an inducible promoter, upon insertion into the amyE locus, restored significant Na+ resistance in both the polar and nonpolar mrpA mutants but did not restore resistance in the null mutant. The mrpA disruption also resulted in an impairment of cytoplasmic pH regulation upon a sudden shift in external pH from 7.5 to 8.5 in the presence of Na+ and, to some extent, K+ in the range from 10 to 25 mM. By contrast, the mrpA tetA(L) double mutant, like the tetA(L) single mutant, completely lost its capacity for both Na+- and K+-dependent cytoplasmic pH regulation upon this kind of shift at cation concentrations ranging from 10 to 100 mM; thus, tetA(L) has a more pronounced involvement than mrpA in pH regulation. Measurements of Na+ efflux from the wild-type strain, the nonpolar mrpA mutant, and the complemented mutant indicated that inducible expression of mrpA increased the rate of protonophore- and cyanide-sensitive Na+ efflux over that in the wild-type in cells preloaded with 5 mM Na+. The mrpA and null mutants showed no such efflux in that concentration range. This is consistent with MrpA encoding a secondary, proton motive force-energized Na+/H+ antiporter. Studies of a polar mutant that leads to loss of mrpFG and its complementation in trans by mrpF or mrpFG support a role for MrpF as an efflux system for Na+ and cholate. Part of the Na+ efflux capacity of the whole mrp operon products is attributable to mrpF. Neither mrpF nor mrpFG expression in trans enhanced the cholate or Na+ resistance of the null mutant. Thus, one or more other mrp gene products must be present, but not at stoichiometric levels, for stability, assembly, or function of both MrpF and MrpA expressed in trans. Also, phenotypic differences among the mrp mutants suggest that functions in addition to Na+ and cholate resistance and pH homeostasis will be found among the remaining mrp genes.  (+info)

Substrates of multidrug resistance-associated proteins block the cystic fibrosis transmembrane conductance regulator chloride channel. (3/61)

1. The effects of physiological substrates of multidrug resistance-associated proteins (MRPs) on cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel currents were examined using patch clamp recording from CFTR-transfected mammalian cell lines. 2. Two MRP substrates, taurolithocholate-3-sulphate (TLCS) and beta-estradiol 17-(beta-D-glucuronide) (E217betaG) caused a voltage-dependent block of macroscopic CFTR Cl- currents when applied to the intracellular face of excised membrane patches, with mean apparent dissociation constants (KDs) of 96+/-10 and 563+/-103 microM (at 0 mV) respectively. The unconjugated bile salts taurocholate and cholate were also effective CFTR channel blockers under these conditions, with KDs of 453+/-44 and 3760+/-710 microM (at 0 mV) respectively. 3. Reducing the extracellular Cl- concentration from 154 to 20 mM decreased the KD for block intracellular TLCS to 54+/-1 microM, and also significantly reduced the voltage dependence of block, by suggesting that TLCS blocks Cl- permeation through CFTR by binding within the channel pore. 4. Intracellular TLCS reduced the apparent amplitude of CFTR single channel currents, suggesting that the duration of block is very fast compared to the gating of the channel. 5. The apparent affinity of block by TLCs is comparable to that of other well-known CFTR channel blockers, suggesting that MRP substrates may comprise a novel class of probes of the CFTR channel pore. 6. These results also suggest that the related proteins CFTR and MRP may share a structurally similar anion binding site at the cytoplasmic face of the membrane.  (+info)

Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives. (4/61)

Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.  (+info)

Uptake of bromosulfophthalein via SO2-4/OH- exchange increases the K+ conductance of rat hepatocytes. (5/61)

In confluent primary cultures of rat hepatocytes, micromolar concentrations of bromosulfophthalein (BSP) lead to a sizeable hyperpolarization of membrane voltage. The effect is a saturable function of BSP concentration yielding an apparent value of 226 micromol/l and a Vmax of -10.3 mV. The BSP-induced membrane hyperpolarization is inhibited by the K+ channel blocker Ba2+, and in cable-analysis and ion-substitution experiments it becomes evident that the effect is due to a significant increase in cell membrane K+ conductance. Voltage changes were attenuated by the simultaneous administration of SO2-4, succinate, and cholate (cis-inhibition) and increased after preincubation with SO2-4 and succinate (trans-stimulation), suggesting that the effect occurs via BSP uptake through the known SO2-4/OH- exchanger. Microfluorometric measurements reveal that BSP-induced activation of K+ conductance is not mediated by changes in cell pH, cell Ca2+, or cell volume. It is concluded that K+ channel activation by BSP (as well as by DIDS and indocyanine green) may reflect a physiological mechanism linking the sinusoidal uptake of certain anions to their electrogenic canalicular secretion.  (+info)

Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. (6/61)

Past studies of atherosclerosis in mice have used chow-based diets supplemented with cholesterol, lipid, and sodium cholate to overcome species resistance to lesion formation. Similar diets have been routinely used in studies with LDL receptor-deficient (LDLR(-/-)) mice. The nonphysiological nature and potential toxicity of cholate-containing diets have led to speculation that atherogenesis in these mice may not accurately reflect the human disease process. We have designed a semipurified AIN-76A-based diet that can be fed in powdered, pelleted, or liquid form and manipulated for the precise evaluation of diet-genetic interactions in murine atherosclerosis. LDLR(-/-) mice were randomly assigned among 4 diets (n=6/diet) as follows: 1, control, 10% kcal lipid; 2, high fat (40% kcal), moderate cholesterol (0.5% by weight); 3, high fat, high cholesterol (1.25% by weight); and 4, high fat, high cholesterol, and 0.5% (wt/wt) sodium cholate. Fasting serum cholesterol was increased in all cholesterol-supplemented mice compared with controls after 6 or 12 weeks of feeding (P<0.01). The total area of oil red O-stained atherosclerotic lesions was determined from digitally scanned photographs. In contrast to the control group, all mice in cholesterol-supplemented dietary groups 2 to 4 had lesions involving 7.01% to 12.79% area of the thoracic and abdominal aorta at 12 weeks (P<0.002, for each group versus control). The distribution pattern of atherosclerotic lesions was highly reproducible and comparable. The histological features of lesions in mice fed cholate-free or cholate-containing diets were similar. This study shows that sodium cholate is not necessary for the formation of atherosclerosis in LDLR(-/-) mice and that precisely defined semipurified diets are a valuable tool for the examination of diet-gene interactions.  (+info)

Alterations in detergent solubility of heterotrimeric G proteins after chronic activation of G(i/o)-coupled receptors: changes in detergent solubility are in correlation with onset of adenylyl cyclase superactivation. (7/61)

Prolonged G(i/o) protein-coupled receptor activation has been shown to lead to receptor internalization and receptor desensitization. In addition, it is well established that although acute activation of these receptors leads to inhibition of adenylyl cyclase (AC), long-term activation results in increased AC activity (especially evident on removal of the inhibitory agonist), a phenomenon defined as AC superactivation or sensitization. Herein, we show that chronic exposure to agonists of G(i)-coupled receptors also leads to a decrease in cholate detergent solubility of G protein subunits, and that antagonist treatment after such chronic agonist exposure leads to a time-dependent reversal of the cholate insolubility. With Chinese hamster ovary and COS cells transfected with several G(i/o)-coupled receptors (i.e., mu- and kappa-opioid, and m(4)-muscarinic), we observed that although no overall change occurred in total content of G(alphai)- and beta(1)-subunits, chronic agonist treatment led to a marked reduction in the ability of 1% cholate to solubilize G(betagamma) as well as G(alphai). This solubility shift is exclusively observed with G(alphai), and was not seen with G(alphas). The disappearance and reappearance of G(alphai) and G(betagamma) subunits from and to the detergent-soluble fractions occur with similar time courses as observed for the onset and disappearance of AC superactivation. Lastly, pertussis toxin, which blocks acute and chronic agonist-induced AC inhibition and superactivation, also blocks the shift in detergent solubility. These results suggest a correlation between the solubility shift of the heterotrimeric G(i) protein and the generation of AC superactivation.  (+info)

Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes. (8/61)

A difficult problem concerning the interaction of DNA with amphiphiles of opposite charge above their critical micelle concentration is the propensity for aggregation of the condensed DNA complexes. In this study, this problem was addressed by attenuating amphiphile charge density within a cholate micelle environment. The amphiphile consisted of a cationic peptide, acetyl-CWKKKPKK-amide, conjugated to dilaurylphos-phatidylethanolamine. In the presence of cholate, multiple equivalents of cationic charge were required to bring about the completion of DNA condensation. At the end point of condensation, stable, soluble DNA-micelle complexes were formed, which by dynamic light scattering exhibited apparent hydro-dynamic diameters between 30 and 60 nm. Aggregation, as measured by static light scattering at 90 degrees and by turbidity, was not observed until further additions of peptide-lipid conjugate were made beyond the end point of DNA condensation. Liposome complexes containing the non-aggregated, compacted DNA were formed by adding dioleoylphosphatidylcholine followed by removing the cholate by dialysis. The resulting complexes were distributed within a narrow density range, the DNA was quantitatively assembled into the liposomes, and liposomes without DNA were not detected. Small particles were formed with a mean hydrodynamic diameter of 77 nm. The liposomal DNA showed complete retention of its supercoiled form and no detectable sensitivity to DNase (25 U/10 microg DNA, 1.5 h, 37 degrees C). The use of an anionic, dialyzable amphiphile to attenuate charge inter-actions between DNA and cationic amphiphiles is a useful technology for the quantitative assembly of compacted DNA into conventional liposomes, with complete protection against nuclease activity.  (+info)

The distribution and the metabolic pathways of bacteria degrading steroid compounds released by eukaryotic organisms were investigated using the bile salt cholate as model substrate. Cholate-degrading bacteria could be readily isolated from freshwater environments. All isolated strains transiently released steroid degradation intermediates into culture supernatants before their further degradation. Cholate degradation could be initiated via two different reaction sequences. Most strains degraded cholate via a reaction sequence known from the model organism Pseudomonas sp. strain Chol1 releasing intermediates with a 3-keto-Δ,sup,1,4,/sup,-diene structure of the steroid skeleton. The actinobacterium Dietzia sp. strain Chol2 degraded cholate via a different and yet unexplored reaction sequence releasing intermediates with a 3-keto-Δ,sup,4,6,/sup,-diene-7-deoxy structure of the steroid skeleton such as 3,12-dioxo-4,6-choldienoic acid (DOCDA). Using DOCDA as substrate, two Alphaproteobacteria, ...
Cyclooxygenase 2 (Cox2) total knockout and myeloid knockout (MKO) mice develop Crohns-like intestinal inflammation when fed cholate-containing high-fat diet (CCHF). We demonstrated that CCHF impaired intestinal barrier function and increased translocation of endotoxin, initiating TLR/MyD88-dependent inflammation in Cox2-KO but not WT mice. Cox2-MKO increased proinflammatory mediators in LPS-activated macrophages, and in the intestinal tissue and plasma upon CCHF challenge. Cox2-MKO also reduced inflammation resolving lipoxin A4 (LXA4) in intestinal tissue, whereas administration of an LXA4 analog rescued disease in Cox2-MKO mice fed CCHF. The apolipoprotein A-I (APOA1) mimetic 4F mitigated disease in both the Cox2-MKO/CCHF and piroxicam-accelerated Il10-/- models of inflammatory bowel disease (IBD) and reduced elevated levels of proinflammatory mediators in tissue and plasma. APOA1 mimetic Tg6F therapy was also effective in reducing intestinal inflammation in the Cox2-MKO/CCHF model. We further ...
Cyclooxygenase 2 (Cox2) total knockout and myeloid knockout (MKO) mice develop Crohns-like intestinal inflammation when fed cholate-containing high-fat diet (CCHF). We demonstrated that CCHF impaired intestinal barrier function and increased translocation of endotoxin, initiating TLR/MyD88-dependent inflammation in Cox2-KO but not WT mice. Cox2-MKO increased proinflammatory mediators in LPS-activated macrophages, and in the intestinal tissue and plasma upon CCHF challenge. Cox2-MKO also reduced inflammation resolving lipoxin A4 (LXA4) in intestinal tissue, whereas administration of an LXA4 analog rescued disease in Cox2-MKO mice fed CCHF. The apolipoprotein A-I (APOA1) mimetic 4F mitigated disease in both the Cox2-MKO/CCHF and piroxicam-accelerated Il10-/- models of inflammatory bowel disease (IBD) and reduced elevated levels of proinflammatory mediators in tissue and plasma. APOA1 mimetic Tg6F therapy was also effective in reducing intestinal inflammation in the Cox2-MKO/CCHF model. We further ...
kualitas Anti Estrogen Steroid produsen & eksportir - Beli Healthy Pharmaceutical CAS 107868-30-4 Anti Estrogen Steroids Compounds Aromasin Exemestane dari Cina produsen.
Brer Rabbit Stories Brer (Brother) Rabbit is a trickster character in folktales of African, African-American, and Native American Culture. Brer Rabbit is the consummate trickster, who typically matches wits with Brer Fox, whom he always bests. The Native American tribes of the eastern seaboard of
Get this from a library! Brer Rabbit in the Briar Patch.. -- Relates how the wily Brer Rabbit outwits Brer Fox who has set out to trap him.
Companies are pooling expertise to develop methods for energy-efficient and sustainable production of steroid compounds by fermentation.
New steroid compounds of the general formula: ##STR1## wherein X is a hydroxyl group and Y is a hydrogen atom, or X and Y, taken together, form an oxo group; each of the two R radicals is independently a hydrogen atom, acyl group, a silyl group, an alkoxycarbonyl group or a ...
Estrogens (also called Oestrogens) are steroid compounds that are important for development and functioning of females of the species. They are named so because they play an important role in the estrous cycle. Their name comes from estrus/oistros (period of fertility for female mammals) + gen/gonos = to generate.
Equipoise is a potent steroid compound that is widely used by the bodybuilders and other sportsmen. You should know everything about this drug in detail before making its use.
TY - JOUR. T1 - Identification of novel extracellular protein for PCB/biphenyl metabolism in Rhodococcus jostii RHA1. AU - Atago, Yuki. AU - Shimodaira, Jun. AU - Araki, Naoto. AU - Othman, Norazizi Bin. AU - Zakaria, Zuriati. AU - Fukuda, Masao. AU - Futami, Junichiro. AU - Hara, Hirofumi. PY - 2016/5. Y1 - 2016/5. N2 - Rhodococcus jostii RHA1 (RHA1) degrades polychlorinated biphenyl (PCB) via co-metabolism with biphenyl. To identify the novel open reading frames (ORFs) that contribute to PCB/biphenyl metabolism in RHA1, we compared chromatin immunoprecipitation chip and transcriptomic data. Six novel ORFs involved in PCB/biphenyl metabolism were identified. Gene deletion mutants of these 6 ORFs were made and were tested for their ability to grow on biphenyl. Interestingly, only the ro10225 deletion mutant showed deficient growth on biphenyl. Analysis of Ro10225 protein function showed that growth of the ro10225 deletion mutant on biphenyl was recovered when exogenous recombinant Ro10225 ...
In this study, we report the ability of R. jostii RHA1 to synthesize and accumulate different storage compounds, including poly(3HB-co-3HV), TAG, wax esters, glycogen and polyP. We found that the RHA1 genome is remarkably rich in genes involved in storage lipid metabolism, with genes encoding 14 WS/DGATs, 54 lipases/esterases and three sets of PHA synthases/depolymerases. These results agree with previous observations in other actinomycetes, like M. tuberculosis, which devotes a large portion of its genome to genes involved in lipid metabolism [61].. Similarly to RHA1, M. tuberculosis contains 15 atf genes encoding WS/DGATs, [9]. Some of these genes, like rv3130c, show the highest induction and activity during hypoxia [9, 62]. Multiple atf genes were also identified in the genomes of other actinomycetes, including three in S. coelicolor [63], 10 in R. opacus [10], 12 in M. bovis AF2122/97, 8 in M. smegmatis mc2155, 5 in N. farcinica IFM 10152 and 4 in Nocardioides sp. JS614 [8]. By contrast, ...
FIG 1 Aerobic 9,10-seco-steroid degradation pathways for cholesterol, cholate, and testosterone. The steroid ring structure is degraded by oxygen-dependent opening and subsequent hydrolytic cleavage of rings A and B. Subsequent degradation of the C and D rings occurs by a mechanism not yet reported. In Actinobacteria, side chain degradation and ring opening can occur simultaneously. Characterized or annotated enzymes involved in the degradation of cholesterol by Actinobacteria are shown in red, those involved in the degradation of cholate by Actinobacteria are shown in lilac, and those involved in the degradation of testosterone or cholate by Proteobacteria are shown in blue. Protein nomenclature is based on that for Rhodococcus jostii RHA1, Mycobacterium tuberculosis H37Rv, Comamonas testosteroni TA441, and Pseudomonas sp. strain Chol1, and not all proteins are named. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Brer (Brother) Rabbit is the main character of folktales told in the South; a tricky guy who outsmarts Brer Fox and Brer Bear who want to do him harm, a...
The title compound, C10H18N2OS, is found to adopt a conformation where the carbonyl bond of the acyl group and the C=S bond of the thiourea group are facing approximately opposite directions. The three C-N bonds in the molecule differ noticeably in length, the N-(C=S) bond on the acyl side being much longer than the corresponding bond on the opposite side of the molecule. © 2006 International Union of Crystallography All rights reserved.. ...
Phytosterols which include plant sterols and stanols, are steroid compounds. These are similar to cholesterol which occurs in plants except variation only ..
Get much testosterone safely. To safely get a much higher level of testosterone, it is best to read through more info about it. There is safe production of testosterone helping to get higher level. Steroids must grow up to achieve it. Steroids are the short term for corticosteroids. It is a synthetic drug that resembles the cortisol. It is a hormone that produces naturally in the adrenal glands. Corticosteroids are not similar to the male hormone steroid compounds used by some athletes. But, Testosterone Base is an ideal product for males wanted to build a lean muscle mass. Also, it increases the energy level. In fact, a lot of male users are happy about using the product while doing their daily workouts. The product is perfect for males doing hard works out. It pushes their body to get firm and have the endurance that it needs while forming a fit body.. Is there any side effect?. Testosterone Base has estrogenic properties. Overused of the product is not good. It can enlarge the breasts, the ...
Pregnenolone is a naturally occurring metabolite that is made in your body. It is often referred to as the mother steroid compound because it is the basic raw material for all steroid hormones in the body.
A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
ID Q0SKT7_RHOJR Unreviewed; 406 AA. AC Q0SKT7; DT 17-OCT-2006, integrated into UniProtKB/TrEMBL. DT 17-OCT-2006, sequence version 1. DT 08-MAY-2019, entry version 69. DE SubName: Full=Transposase {ECO:0000313,EMBL:ABG91849.1}; GN OrderedLocusNames=RHA1_ro00013 {ECO:0000313,EMBL:ABG91849.1}; OS Rhodococcus jostii (strain RHA1). OC Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; OC Rhodococcus. OX NCBI_TaxID=101510 {ECO:0000313,EMBL:ABG91849.1, ECO:0000313,Proteomes:UP000008710}; RN [1] {ECO:0000313,Proteomes:UP000008710} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHA1 {ECO:0000313,Proteomes:UP000008710}; RX PubMed=17030794; DOI=10.1073/pnas.0607048103; RA McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., RA Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., RA Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., RA Schein J.E., Shin H., Smailus D., Siddiqui A.S., Marra M.A., RA Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., ...
AIMS/HYPOTHESIS: An accumulation of ceramides has been implicated in the generation of insulin resistance in skeletal muscle upon an oversupply of fatty acid. Different ceramide species are generated through the actions of ceramide synthases (CerSs), which incorporate specific acyl side chains. We tested whether particular CerS isoforms promoted insulin resistance through the generation of more inhibitory ceramide species, thus representing potential targets for intervention. METHODS: CerS isoforms CerS1, CerS2, CerS4, CerS5 and CerS6 were overexpressed in L6 myotubes using adenovirus, and cells were treated with palmitate and stimulated with insulin. Alternatively, CerS isoforms were knocked down using siRNAs. Sphingolipids were examined by mass spectrometry and tracer incorporation. Phosphorylation of IRS1 and Akt was measured by immunoblotting, while glucose disposal was assessed by measuring GLUT4 translocation and the incorporation of [(14)C]glucose into glycogen. RESULTS: Palmitate treatment
Brer Rabbit Blackstrap Molasses (unsulphured nutrition facts and nutritional information. Find calories, carbs, and nutritional contents for Brer Rabbit Blackstrap Molasses (unsulphured and over 2,000,000 other foods at MyFitnessPal.com.
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Here, we screened steroid compounds to obtain a drug expected to block host inflammatory responses and MERS-CoV replication. Ciclesonide, an inhaled corticosteroid, suppressed replication of MERS-CoV and other coronaviruses, including SARS-CoV-2, the cause of COVID-19, in cultured cells. The effective concentration (EC90) of ciclesonide for SARS-CoV-2 in differentiated human bronchial tracheal epithelial cells was 0.55 μM. Eight consecutive passages of 43 SARS-CoV-2 isolates in the presence of ciclesonide generated 15 resistant mutants harboring single amino acid substitutions in non-structural protein 3 (nsp3) or nsp4. Of note, ciclesonide suppressed replication of all these mutants by 90% or more, suggesting that these mutants cannot completely overcome ciclesonide blockade. Under the microscope, the viral RNA replication-transcription complex in cells, which is thought to be detectable using antibodies specific for nsp3 and double stranded RNA, was observed to fall in the presence of ...
Boldenone is also known under the trade names Equipoise, Ganabol, Equigan and Ultragan Equipoise makes you vascular and gives you strength. Youll lean out and youll have a boost your cardio. Body builders use it at the end with harderners. Equipoise is a steroid compound that can give users slow but steady gains...
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Shop for Brer Rabbit molasses products. Try it today in 3 flavors: Full, Mild and Blackstrap. Use Brer Rabbit as a sugar substitute when cooking and baking.
Currently, we are investigating how steroid-degrading bacteria like Rhodococcus jostii access water-insoluble steroid substrates like cholesterol, which normally occur in biological membranes. We are using a liposome-based model system with R. jostii and mutant strains. In addition, we are developing tools to explore bacterial genomes and environmental metagenomes for genes encoding steroid catabolism pathways in order to expand our knowledge of the diversity of steroid catabolism and the roles of steroid-degraders in diverse ecosystems.. ...
When we talk about plant sterols and stanols, what we are really talking about collectively are compounds that belong to the phytosterol class of plant substances. They are naturally occurring steroid compounds according to Wikipedia, and are found various forms in plants with over 200 different types identified. Not only are these compounds prolific among supplements to lower cholesterol, they are also added to foods in order to fortify them, and are commonly found in goods like orange juice and margarines. Plant sterols supplements have been proven both effective and safe in terms of lowering cholesterol numbers.. ...
When we talk about plant sterols and stanols, what we are really talking about collectively are compounds that belong to the phytosterol class of plant substances. They are naturally occurring steroid compounds according to Wikipedia, and are found various forms in plants with over 200 different types identified. Not only are these compounds prolific among supplements to lower cholesterol, they are also added to foods in order to fortify them, and are commonly found in goods like orange juice and margarines. Plant sterols supplements have been proven both effective and safe in terms of lowering cholesterol numbers.. ...
Mifepristone is a synthetic steroid compound used as a pharmaceutical. It is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. Mifepristone is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushings Syndrome (due to ectopic/neoplastic ACTH/Cortisol secretion). During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed-often amid controversy. It is marketed under tradenames Mifegyne, Zacafemyl and Mifeprex. ...
Allergic contact dermatitis is the result of exposure to substances that sensitize the skin. Each time the foot is exposed to the substance, an inflammatory reaction occurs. Some people are allergic to the substances in sock dyes or certain shoe materials. Adhesive tapes can cause an allergic reaction with blisters or a rash developing beneath the tape. Because of the heat and the accumulation of moisture beneath the tape, an acute Athletes Foot infection can also be caused by an allergic reaction to the adhesive. Treatments include the use of cool compresses, topical steroid compounds (like hydrocortisone creams), and antifungal creams.. ...
Allergic contact dermatitis is the result of exposure to substances that sensitize the skin. Each time the foot is exposed to the substance, an inflammatory reaction occurs. Some people are allergic to the substances in sock dyes or certain shoe materials. Adhesive tapes can cause an allergic reaction with blisters or a rash developing beneath the tape. Because of the heat and the accumulation of moisture beneath the tape, an acute Athletes Foot infection can also be caused by an allergic reaction to the adhesive. Treatments include the use of cool compresses, topical steroid compounds (like hydrocortisone creams), and antifungal creams.. ...
General Information: This strain was isolated from soil contaminated with gamma-hexachlorocyclohexane (lindane: a toxic insecticide) in Japan. Polychlorinated biphenyl degrading bacterium. Rhodococcus jostii is capable of degrading a wide variety of polychlorinated biphenyls (PCBs), which are toxic compounds produced by industry, and is studied extensively for this reason. This microbe is being examined thoroughly under different environmental conditions in order to better understand metabolic pathways and gene functions. ...
SUGAR COOKIES (BRER RABBIT MOLASSES) recipe by Pat Simmons, is from The Standley Family Cookbook, one of the cookbooks created at FamilyCookbookProject.com. Family cookbooks are an important way to preserve our mealtime traditions for future generations with individual printed recipes or your own professionally printed cookbook.
Definition of cholate synthetase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Steroid cycles are used by people for mainly three purposes which include: to improve the muscle mass and strength of the body, to promote a harder and leaner physique and also to improve athletic performance. It is for this reason that a number of body builders and athletes plan a proper steroid cycle to gain maximum benefit. A steroid cycle is defined as the time period or the duration in which a person uses anabolic steroids. The duration of the steroid cycle is between four to fifteen weeks which depends on the goals which have to be accomplished and also on the experience and anabolic compounds which are taken. A person generally takes a single steroid drug in a cycle and consuming more than one steroid compound in a cycle is referred to as stacking.. Stacking can lead to more gain in muscle mass and strength but is recommended only for advanced steroid users. In order to start a steroid cycle, a person must first understand and gain knowledge about steroid, risks, side effects, post cycle ...
Steroids represent a category of natural merchandises with diverse curative belongingss. It has been observed that minor alterations in the molecular construction of steroids can impact their biological activity [ 4,5 ] . Hence legion research have been conducted to better the activity of bing steroid compounds and to synthesise fresh steroidal compounds with pharmacological activity, and therefore the most important country of these research is the transmutation of steroids utilizing biocatalysts.. Biotransformation could be defined as the alteration of an organic compound into a recoverable merchandise by chemical reactions catalysed by enzymes arising from a biological system [ 6 ] . It should be noted that the organic compound which is the substrate is non involved in the primary or secondary metamorphosis of the biological system concerned, and therefore distinguishes this procedure from biogenesis. The biotransformation of steroids is one of the most of import microbic procedures that are ...
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance.Salts of cholic acid are called cholates.Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver, where it is synthesized from cholesterol.. Get Price ...
TCS application on AD lesions does reduce Staphylococcus aureus bacterial load, likely via decreasing the inflammatory cytokines that inhibit antimicrobial peptide production. There is some worry that TCS may impair the process of wound healing and re-epithelialization, although excoriated and fissured lesions should be included in treatment given that the underlying inflammation and pruritus lead to these secondary changes. Allergic contact dermatitis/type IV hypersensitivity can develop to TCS or other ingredients in their formulations, such as propylene glycol and preservatives. This should be considered if lesions fail to respond as expected or worsen with application. Patch testing is needed to determine if the allergen is the steroid compound itself or a component of the vehicle. Development of tachyphylaxis is of concern for some practitioners, where the efficacy is thought to decrease with repeated use of the same agent, although data are lacking to suggest that this is a significant ...
New Supplement! Tame your testosterone with our new Estrogen supplement! Estrogen Is A Group Of Steroid Compounds, Important To The Estrous Cycle And Functions As The Primary Female Sex Hormone: Estradiol: Secreted Chiefly By The Ovaries. Most Potent Estrogen; Critical Impact On Reproductive And Sexual Functions; Affects Bone Structure. Estrone: An Estrogenic Hormone Secreted By The Ovary; Found Chiefly As A Metabolite Of Estradiol. Estriol: A Reduction Product Of Estrone And Estradiol. Dhea Is Converted To Estriol By The Placenta. Levels Are Usually Stable After Menopause. These estrogen drops help to increase estrogen levels. Use only as directed. One to ten drops under the tongue daily. Keep out of reach of children ...
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ethyl 3,4-seco-8(14-13R)abeo-17,13-friedo-4(28),7,14,24-lanostatetraen-26,23-olide-23-hydroxy-3-oate: from Abies sachalinensis; structure in first source
Weve certainly enjoyed our fill of homemade molasses cookies this holiday season. Granny graciously sent up a few batches and then Rachel requested the recipe. So Granny and Poppa shared the recipe and a few tips with us. The first major tip is that Brer Rabbit molasses has the best flavor. In fact this recipe was originally taken off the Brer Rabbit molasses bottle. This recipe does produce a rather large batch; next time we will probably halve it. Here is the recipe as Poppa emailed it to us ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Cable news has created an entirely new breed of blowhards -- and the style has infected banking and even the arts. The following is an excerpt from
Author summary The anaerobic, spore-forming bacterium Clostridium difficile (C. difficile) is a prominent pathogen in hospitals worldwide and the leading cause of nosocomial diarrhea. Numerous risk factors are associated with C. difficile infections (CDIs) including: antibiotics, advanced age, vitamin D deficiency, and proton pump inhibitors. Antibiotic use disrupts the intestinal microbiota allowing for C. difficile to colonize, however, why these other risk factors increase CDI incidence is unclear. Notably, deficient intestinal calcium absorption (i.e., increased calcium levels) is associated with these risk factors. In this work, we investigate the role of calcium in C. difficile spore germination. C. difficile spores are the infectious particles and they must become metabolically active (germinate) to cause disease. Here, we show that calcium is required for C. difficile germination, specifically activating the key step of cortex hydrolysis, and that this calcium can be derived from either within
In todays culture there is unprecedented pressure for young men to adhere to an unnatural standard of attractiveness. Society tells us the bigger and stronger you are, the more respect you command. However untrue this notion may be, it lends suggestion to why use of anabolic steroids in young Illinois men has risen in the past decade. Anabolic steroids are bought and sold on the streets like any other illegal drug and like any other illegal drug, you will be prosecuted if caught possessing them without a valid medical prescription.. The Illinois Controlled Substances Act expressly states, Anabolic Steroids means any drug or hormonal substance, chemically and pharmacologically related to testosterone. The Act then continues to enumerate fifty-seven different types of steroid compounds by there scientific properties. The fifty-seven chemicals are so complicated, unless you are fluent in organic chemistry or have a working knowledge of chemical compounds; you might not know that you are ...
TCS application on AD lesions does reduce Staphylococcus aureus bacterial load, likely via decreasing the inflammatory cytokines that inhibit antimicrobial peptide production. There is some worry that TCS may impair the process of wound healing and re-epithelialization, although excoriated and fissured lesions should be included in treatment given that the underlying inflammation and pruritus lead to these secondary changes. Allergic contact dermatitis/type IV hypersensitivity can develop to TCS or other ingredients in their formulations, such as propylene glycol and preservatives. This should be considered if lesions fail to respond as expected or worsen with application. Patch testing is needed to determine if the allergen is the steroid compound itself or a component of the vehicle. Development of tachyphylaxis is of concern for some practitioners, where the efficacy is thought to decrease with repeated use of the same agent, although data are lacking to suggest that this is a significant ...
TCS application on AD lesions does reduce Staphylococcus aureus bacterial load, likely via decreasing the inflammatory cytokines that inhibit antimicrobial peptide production. There is some worry that TCS may impair the process of wound healing and re-epithelialization, although excoriated and fissured lesions should be included in treatment given that the underlying inflammation and pruritus lead to these secondary changes. Allergic contact dermatitis/type IV hypersensitivity can develop to TCS or other ingredients in their formulations, such as propylene glycol and preservatives. This should be considered if lesions fail to respond as expected or worsen with application. Patch testing is needed to determine if the allergen is the steroid compound itself or a component of the vehicle. Development of tachyphylaxis is of concern for some practitioners, where the efficacy is thought to decrease with repeated use of the same agent, although data are lacking to suggest that this is a significant ...
Methandienone (also known as methandrostenolone, Dbol, dianabol) is an orally-effective anabolic steroid originally developed in Germany and released in the US in the early 1960s by Ciba Specialty Chemicals. This is a derivative from testosterone, one of the most popular steroid compounds in the world and the second steroid (after testosterone) ever produced. Methandienone promotes dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. It also has the effect of decreasing the steroids affinity for sex hormone binding globulin. As a result, methandrostenolone is significantly more active than an equivalent quantity of testosterone, resulting in rapid growth of muscle tissue. However, the concomitant elevation in estrogen levels - a result of the aromatization of methandrostenolone - results in significant water retention. Hence, do not forget to perform blood works and use an aromatase inhibitor.. In summary, this is a very good drug, and a ...
"Americas Bean-to-Bar and Chocolatier Competition Winners 2019". International Cholate Awards. 26 June 2019. Cuozzo, Steve (19 ...
Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids ...
YufF (MrpF) appears to catalyze cholate efflux, possibly by a Na+ symport mechanism. It plays a major role in Na+ extrusion and ... multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis". Journal of ... and alkali but not cholate resistance". Journal of Bacteriology. 182 (20): 5663-70. doi:10.1128/jb.182.20.5663-5670.2000. PMC ...
The spermicides benzalkonium chloride and sodium cholate are used in some contraceptive sponges. Benzalkonium chloride might ...
"Enantioseparation of palonosetron hydrochloride by micellar electrokinetic chromatography with sodium cholate as chiral ...
"The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J Biol Chem. 275 (21): 15605-8 ...
"Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1- ...
"A Study of the Photochemical Response of o-Nitrobenzyl Cholate Derivatives in P(MMA-MAA) Matrices". Journal of Polymer Science ...
The fees were paid to the San Antonio firm Goode, Casseb, Jones, Riklin, Cholate, and Watson. Additional amounts beyond the $ ...
2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J. Biol. Chem. 275 (21 ...
"The effect of octylglucoside and sodium cholate in Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to soft ...
"The effect of octylglucoside and sodium cholate in Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to soft ...
The sheets in α-MoTe2 can be separated and dispersed in water with a sodium cholate surfactant and sonication. It forms an ...
Se75-SeHCAT (23-Seleno-25-homo-tauro-cholate) Bile salt absorption Oral In-vivo Imaging ...
... dehydroepiandrosterone and their glucuronide and sulfate conjugates in serum using sodium cholate micelle capillary ...
... cholate solution, 0.1 grams of cholate are dissolved in 10 mL of water. Volumetric flasks are the most appropriate piece of ...
This particular protein is responsible for the transport of taurocholate and other cholate conjugates from hepatocytes (liver ...
... (EC 1.17.99.5, cholate 7alpha-dehydroxylase, 7alpha-dehydroxylase, bile acid 7-dehydroxylase) is ... cholate + NADH + H+ (2) lithocholate + NAD+ + H2O ⇌ {\displaystyle \rightleftharpoons } chenodeoxycholate + NADH + H+ Bile-acid ...
The best of these were the perfused hepatic mass (PHM) by quantitative laparoscopic liver spleen scan (QLSS) and oral Cholate ...
... cholates MeSH D04.808.105.225.130.330.850 - sodium cholate MeSH D04.808.105.225.261 - dehydrocholic acid MeSH D04.808.105.225. ... cholates MeSH D04.808.221.430.130.330.850 - sodium cholate MeSH D04.808.221.430.265 - dehydrocholic acid MeSH D04.808.221.430. ...
... and 25 mg of sodium cholate). Pharmatex contains 60 mg of benzalkonium chloride. Some people are allergic to the spermicide ...
CDCA-NBD Cholate (CA) Cholecystokinin octapeptide (CCK-8) Dehydroepiandroserone-3-sulfate (DHEAS) Deltorphin II ...
... cholate-CoA ligase EC 6.2.1.8: oxalate-CoA ligase EC 6.2.1.9: malate-CoA ligase EC 6.2.1.10: acid-CoA ligase (GDP-forming) EC ...
Chemical treatments- anionic detergent: (Sodium dodecyl sulfate (SDS)), sodium cholate, enzymatic agent (Trypsin), non-ionic ...
... cholate + CoA Thus, the two substrates of this enzyme are choloyl-CoA and H2O, whereas its two products are cholate and CoA. ...
Cholate-CoA ligase, an enzyme Pennsylvania Station (Baltimore), Maryland, US, station code A common abbreviation for the U.S. ...
... taurocholate and cholate), steroid conjugates, thyroid hormones, anionic oligopeptides, drugs, toxins and other xenobiotics. ...
... (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl ... Cholate---CoA+ligase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... is an enzyme with systematic name cholate:CoA ligase (AMP-forming). This enzyme catalyses the following chemical reaction (1) ... ATP + cholate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + choloyl-CoA (2) ATP + (25R)-3alpha,7alpha,12alpha ...
EC 6.2.1.7: Cholate--CoA ligase. *EC 6.2.1.8: Oxalate--CoA ligase ...
Cholate-CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl ... Cholate---CoA+ligase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... is an enzyme with systematic name cholate:CoA ligase (AMP-forming). This enzyme catalyses the following chemical reaction (1) ... ATP + cholate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + choloyl-CoA (2) ATP + (25R)-3alpha,7alpha,12alpha ...
Definition of cholate synthetase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ...
... and sodium cholate (NaC), on DPPC small unilamellar vesicles have been investigated using the steady-state fluorescence ... Effects of two bile salts, namely sodium deoxycholate (NaDC) and sodium cholate (NaC), on DPPC small unilamellar vesicles have ... Effect of sodium deoxycholate and sodium cholate on DPPC vesicles: A fluorescence anisotropy study with diphenylhexatriene. ...
Find Sodium Cholate from China Manufacturer, Manufactory, Factory and Supplier - Anhui Chem-Bright Bioengineering Co., Ltd. on ... Product name】 Sodium cholate. 【CAS No.】 11006-55-6. 【Functions and actions】Long-term drainage of biliary tract, fistula and ...
The histological features of lesions in mice fed cholate-free or cholate-containing diets were similar. This study shows that ... Past studies of atherosclerosis in mice have used chow-based diets supplemented with cholesterol, lipid, and sodium cholate to ... The nonphysiological nature and potential toxicity of cholate-containing diets have led to speculation that atherogenesis in ... sodium cholate. Fasting serum cholesterol was increased in all cholesterol-supplemented mice compared with controls after 6 or ...
Studies on mono amine oxidase part 44 effect of sodium cholate on mitochondrial mono amine oxidase from rabbit liver ... Sodium cholate had no effect on MAO activity in rabbit serum. The pH optimum and pS maximum for tyramine were not changed when ... Sodium cholate acted as an uncompetitive inhibitor for tyramine and benzylamine oxidation. After addition of various ... When 50 mM sodium cholate was added, 50% of the activities were found in each fraction with tyramine as substrate, while when ...
Use Cholate in diagnostic reagents, such as for the determination of cholesterol and triglycerides.. +- ...
Crystals of calcium cholate chloride heptahydrate, CaC24H39O7Cl . 7H2O, are monoclinic, space group P2(1), with a = 11.918(2), ... Identification of a thiolase gene essential for β-oxidation of the acyl side chain of the steroid compound cholate in ... The conformations of three cholate foldamers and one molecular basket were studied by fluorescence and NMR spectroscopy. In… ( ... FLAG- and HA-tagged M2 muscarinic receptors from coinfected Sf9 cells have been purified in digitonin-cholate and reconstituted ...
Cholate--CoA ligase,Fatp5,FATP-5,Fatty acid transport protein 5,Rat,Rattus norvegicus,Slc27a5,Solute carrier family 27 member ... Product name : Acsb,BA-CoA ligase,BACS,BAL,Bile acid-CoA ligase,Bile acyl-CoA synthetase,Cholate--CoA ligase,Fatp5,FATP-5,Fatty ... Index / EIAab / Acsb,BA-CoA ligase,BACS,BAL,Bile acid-CoA ligase,Bile acyl-CoA synthetase,Cholate--CoA ligase,Fatp5,FATP-5, ... EIAAB36859 Acsb,BA-CoA ligase,BACS,BAL,Bile acid-CoA ligase,Bile acyl-CoA synthetase,Cholate--CoA ligase,Fatp5,FATP-5,Fatty ...
Category: Health News Tags: cholate, cholesterol, death, diet. Post navigation. ← Fodmap diet and oatmeal Keto adapted vs ... Table 2 Impact of dietary Hepatology Importantly, Chow cholesterol animals exhibited cholate GSH content at day diet of ... Cellular and Cholesterol Gastroenterology and cholxte in mouse models of non-alcoholic cholate liver disease NAFLD and non- ...
... sodium cholate Precursor products, sodium cholate Downstream products ect. ... Current Page: Home › Chemical Dictionary › 361-09-1 › sodium cholate 361-09-1 Precursor and Products ...
thortons cholate heart lollipop. 4 This Thorntons Chocolate Heart Lollipop was a really good buy. Really yummy chocolate. ...
Cholate degradation could be initiated via two different reaction sequences. Most strains degraded cholate via a reaction ... Cholate degradation could be initiated via two different reaction sequences. Most strains degraded cholate via a reaction ... strain Chol2 degraded cholate via a different and yet unexplored reaction sequence releasing intermediates with a 3-keto-Δ4,6- ... strain Chol2 degraded cholate via a different and yet unexplored reaction sequence releasing intermediates with a 3-keto-Δ,sup, ...
4-diboronic acid/sodium cholate coated single-walled carbon nanotubes . It has composition images, properties, Characterization ... benzene-1,4-diboronic acid/sodium cholate coated single-walled carbon nanotubes. ...
Page contains details about in cholesterol-loaded POPC/POPG large unilamellar vesicle macrocyclic cholate trimer transmembrane ... in cholesterol-loaded POPC/POPG large unilamellar vesicle macrocyclic cholate trimer transmembrane nanopore. ...
3. 3. The cholate residue gave a trilamellar image by electron microscopy and in condensed form gave a smaller membrane repeat ... 2. 2. Treatment with cholate, glycocholate, taurocholate, or with Triton X-100 gave lipid-depleted residues. These could still ... Comparison of residues after cholate and Triton x-100 treatments. *Coleman R ...
Sodium Cholate, Reagent SO162 , 361-09-1 , C24H39NaO5 , Spectrum Chemical Sodium Cholate, Reagent The Reagent grade denotes ...
cholate salt (CHEBI:23169) has functional parent cholic acid (CHEBI:16359). cholic acid 24-O-(β-D-glucuronide) (CHEBI:137791) ...
The sodium cholate was slowly added to the phosphate buffer with stirring until dissolved. The deoxy cholate was then added and ...
sodium cholate. 3. %. 3.00. oleic acid. 2. %. 2.00. citric acid. 500. mM. 9.60. ...
Sodium cholate. 3 g. Agar. 15 g. Distilled water. 1 liter. Prepare in flask at least 3 times larger than required volume of ...
フィンガープリント Solubilization of SWNTs in aqueous micelles of sodium cholate and sodium deoxycholate の研究トピックを掘り下げます。これらはともに一意のフィンガー ... N2 - Sodium cholate and sodium deoxycholate are aqueous micelle-forming surfactants that are often used for biological use. We ... AB - Sodium cholate and sodium deoxycholate are aqueous micelle-forming surfactants that are often used for biological use. We ... Sodium cholate and sodium deoxycholate are aqueous micelle-forming surfactants that are
cholate. Comparative. formula (5). t-butyl. 443.2. 0.16 μm. Example 4. cholate. ...
... and cholate). The effect of mutations in prtS (protease), mucBP (MUCin-Binding Protein), and srtA genes in ST LMD-9 in these ...
... sodium cholate; deoxycholic acid; sodium deoxycholate; taurocholic acid; sodium taurocholate; taurodeoxycholic acid; sodium ...
... sodium cholate; methyl cholate; benzyldimethylhexadecylammonium cholate; methyl 1,3-dihydroxycholan-24-o ate; and ... trioctylmethylammonium cholate); cholic acid glucuronide; cholyl-coenzyme A; cholyl-lysylfluorescein; cholyldiglycylhistamine; ...
Sodium Cholate CAS No.: 11006-55-6. * 3-Methyl-1-phenylbutylamine CAS No.: 42290-97-1. ...
"Americas Bean-to-Bar and Chocolatier Competition Winners 2019". International Cholate Awards. 26 June 2019. Cuozzo, Steve (19 ...
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4.7 mmol/l or 2 g/l sodium cholate. 10 mmol/l p-chlorophenol ...
  • Effects of two bile salts, namely sodium deoxycholate (NaDC) and sodium cholate (NaC), on DPPC small unilamellar vesicles have been investigated using the steady-state fluorescence anisotropy ( r ss ) of diphenylhexatriene (DPH) as a tool. (springer.com)
  • Sodium cholate and sodium deoxycholate are aqueous micelle-forming surfactants that are often used for biological use. (elsevier.com)
  • Ishibashi, A & Nakashima, N 2005, Solubilization of SWNTs in aqueous micelles of sodium cholate and sodium deoxycholate . (elsevier.com)
  • taurocholoate, deoxycholate, and cholate). (springer.com)
  • Deoxycholate but not cholate enhanced (1) the rate of Na+ influx, (2) the rate of influx of D-glucose and L-alanine in the absence of a Na+ gradient and (3) the rate of efflux of D-glucose and L-alanine from vesicles preloaded with this sugar or amino acid. (portlandpress.com)
  • 6. A solution as recited in claim 1 wherein the salt of cholic acid is sodium cholate. (patentgenius.com)
  • Identification of a thiolase gene essential for β-oxidation of the acyl side chain of the steroid compound cholate in Pseudomonas sp. (semanticscholar.org)
  • MAO [monoamine oxidase] activity decreased with increase in the concentration of sodium cholate when either tyramine or benzylamine was used as substrate and this activity was inhibited completely with 50 mM sodium cholate. (eurekamag.com)
  • The pH optimum and pS maximum for tyramine were not changed when 10mM sodium cholate was added, while when benzylamine served as substrate inhibition with an excess of the substrate concentration occurred. (eurekamag.com)
  • When 50 mM sodium cholate was added, 50% of the activities were found in each fraction with tyramine as substrate, while when benzylamine was used as substrate, a 35% activity in the supernatant and a 65% activity in the precipitate fractions were noted. (eurekamag.com)
  • Substrate specificities for MAO activity in the supernatant and precipitate treated with 50 mM sodium cholate were quite similar to specificities in the mitochondria. (eurekamag.com)
  • The distribution and the metabolic pathways of bacteria degrading steroid compounds released by eukaryotic organisms were investigated using the bile salt cholate as model substrate. (uni-konstanz.de)
  • Using DOCDA as substrate, two Alphaproteobacteria, strains Chol10-11, were isolated that produced the same cholate degradation intermediates as strain Chol2. (uni-konstanz.de)
  • The two primary bile acids are chenodeoxycholate and cholate. (livestrong.com)
  • Cholate inhibits high-fat diet-induced hyperglycemia and obesity with acyl-CoA synthetase mRNA decrease. (nature.com)
  • Interaction of sodium cholate with multilamellar liposomes & the properties of cholate vesicles. (bvsalud.org)
  • A self-assembled, luminescent europium cholate hydrogel: a novel approach towards lanthanide sensitization. (semanticscholar.org)
  • report the preparation of disubstituted metal cholate hydrogel without any proper identification of products [17]. (thefreedictionary.com)
  • With increase in the concentration of sodium cholate, MAO activities in the supernatant increased and those in he precipitate decreased. (eurekamag.com)
  • Cholate (1) also showed activity against MRSA (MICs=125μg/mL) and glycocholic acid (6) against S. cerevisiae (MICs=15.6μg/mL). (ovid.com)
  • Past studies of atherosclerosis in mice have used chow-based diets supplemented with cholesterol, lipid, and sodium cholate to overcome species resistance to lesion formation. (harvard.edu)
  • Use Cholate in diagnostic reagents, such as for the determination of cholesterol and triglycerides. (roche.com)
  • Cellular and Cholesterol Gastroenterology and cholxte in mouse models of non-alcoholic cholate liver disease NAFLD and non-alcoholic steatohepatitis. (atbrand.eu)
  • Table 2 Impact of dietary Hepatology Importantly, Chow cholesterol animals exhibited cholate GSH content at day diet of treatment, which. (atbrand.eu)
  • We have obtained good results using several different detergents, such as digitonin, CHAPS, cholate and others. (pewtrusts.org)
  • strain Chol2 degraded cholate via a different and yet unexplored reaction sequence releasing intermediates with a 3-keto-Δ 4,6 -diene-7-deoxy structure of the steroid skeleton such as 3,12-dioxo-4,6-choldienoic acid (DOCDA). (uni-konstanz.de)
  • Disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) in mice prevents the synthesis of cholate, a primary bile acid, and its metabolites. (nih.gov)
  • The results implicate cholate as an important negative regulator of bile acid synthesis and provide preliminary evidence for ligand-specific gene activation by a nuclear receptor. (nih.gov)
  • Deoxycholic Acid A bile acid formed by bacterial action from cholate. (scitoys.com)
  • This enzyme catalyses the following chemical reaction (1) ATP + cholate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + choloyl-CoA (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA This enzyme requires Mg2+ for activity. (wikipedia.org)
  • The conformations of three cholate foldamers and one molecular basket were studied by fluorescence and NMR spectroscopy. (semanticscholar.org)
  • MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. (dovepress.com)
  • Sodium cholate had no effect on MAO activity in rabbit serum. (eurekamag.com)
  • Preferential solvation within hydrophilic nanocavities and its effect on the folding of cholate foldamers. (semanticscholar.org)
  • These results indicate that bacteria with potentially different pathways for cholate degradation coexist in natural habitats and may interact via interspecies cross-feeding. (uni-konstanz.de)
  • Bile salts such as cholate are steroid compounds occurring ubiquitously in the environment through excretion by animals. (semanticscholar.org)
  • The nonphysiological nature and potential toxicity of cholate-containing diets have led to speculation that atherogenesis in these mice may not accurately reflect the human disease process. (harvard.edu)
  • This study shows that sodium cholate is not necessary for the formation of atherosclerosis in LDLR−/− mice and that precisely defined semipurified diets are a valuable tool for the examination of diet-gene interactions. (harvard.edu)
  • The histological features of lesions in mice fed cholate-free or cholate-containing diets were similar. (harvard.edu)
  • Physicochemical properties of a mixed micellar system of sodium dodecyl sulfate (SDS) and sodium cholate (SC) were investigated. (edu.au)
  • Noxynol-9, benzalkonium chloride & sodium cholate are the main active ingredients found in spermicidal products. (yoatzot.org)
  • To make cholate increase, in another container, use same recipe except for the flour. (mrfood.com)
  • Some of my goals are pretty simple, like make hot apple cider and hot cholate from scratch, while some are a bit more elaborate, like knit a scarf for Kirkens bymisjon (even though the pattern itself is pretty simple) and in general do some autumn crafts. (blogspot.com)
  • Table 2 Impact of dietary Hepatology Importantly, Chow cholesterol animals exhibited cholate GSH content at day diet of treatment, which. (atbrand.eu)
  • In February, Nutella-maker Ferrero similarly cited growing costs when it said it would reduce the size of jars of its world-famous nutty cholate spread in the U.K. and Belgium while keeping price unaltered. (globalnews.ca)