Detailed account or statement or formal record of data resulting from empirical inquiry.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.
A family of sterols commonly found in plants and plant oils. Alpha-, beta-, and gamma-isomers have been characterized.
A class of organic compounds known as STEROLS or STEROIDS derived from plants.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Uptake of substances through the lining of the INTESTINES.
A butterlike product made of refined vegetable oils, sometimes blended with animal fats, and emulsified usually with water or milk. It is used as a butter substitute. (From Random House Unabridged Dictionary, 2d ed)
Cholesterol present in food, especially in animal products.
A combustible, gaseous mixture of low-molecular weight PARAFFIN hydrocarbons, generated below the surface of the earth. It contains mostly METHANE and ETHANE with small amounts of PROPANE; BUTANES; and higher hydrocarbons, and sometimes NITROGEN; CARBON DIOXIDE; HYDROGEN SULFIDE; and HELIUM. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The temperature at which a substance changes from one state or conformation of matter to another.
Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
Skills and strategies, unrelated to the traits a test is intended to measure, that may increase test takers' scores -- may include the effects of coaching or experience in taking tests. (ERIC Thesaurus)
A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.
The arterial blood vessels supplying the CEREBRUM.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
The nonstriated involuntary muscle tissue of blood vessels.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.

Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. (1/18)

Microsomal epoxide hydrolase (mEH) is a bifunctional protein that plays a central role in carcinogen metabolism and is also able to mediate the sodium-dependent uptake of bile acids into hepatocytes. Studies have identified a subject (S-1) with extremely elevated serum bile salt levels in the absence of observable hepatocellular injury, suggesting a defect in bile acid uptake. In this individual, mEH protein and mEH mRNA levels were reduced by approximately 95% and 85%, respectively, whereas the expression and amino acid sequence of another bile acid transport protein (NTCP) was unaffected. Sequence analysis of the mEH gene (EPHX1) revealed a point mutation at an upstream HNF-3 site (allele I) and in intron 1 (allele II), which resulted in a significant decrease in EPHX1 promoter activity in transient transfection assays. Gel shift assays using a radiolabeled oligonucleotide from each region resulted in specific transcription factor binding patterns, which were altered in the presence of the mutation. These studies demonstrate that the expression of mEH is greatly reduced in a patient with hypercholanemia, suggesting that mEH participates in sodium-dependent bile acid uptake in human liver where its absence may contribute to the etiology of this disease.  (+info)

Structural, thermoanalytical and molecular modeling studies on N-(3-hydroxypropyl) 3 alpha,12 alpha-dihydroxy-5 beta-cholan-24-amide and its monohydrates. (2/18)

The synthetic method for preparing N-(3-hydroxypropyl) 3 alpha,12 alpha-dihydroxy-5 beta-cholan-24-amide can lead to formation of at least three different crystal forms - an anhydrous compound and two monohydrates. The structural and thermal properties of these forms have been characterized by 13C-CP/MAS-NMR and IR spectroscopy, thermo- gravimetry, differential scanning calorimetry and by powder and single crystal x-ray crystallography. In addition, theoretical 13C-NMR chemical shift calculations were also performed for the anhydrous compound and for the first monohydrate, starting from single crystal structures and the structures of these species have now been verified. The first monohydrate, C27H47NO4 x H2O, crystallizes in orthorhombic space group P2(1)2(1)2(1) with cell parameters: a = 7.1148(2), b = 18.1775(5), c = 20.1813(6), Z = 4.  (+info)

The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory beta1 subunit. (3/18)

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Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel beta1-subunit by a novel nonsteroidal agent. (4/18)

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Glyco-7 alpha, 12 alpha-dihydroxy-5 beta-cholanic acid as internal standard for high-pressure liquid chromatographic analysis of conjugated bile acids. (5/18)

Glyco-7 alpha, 12 alpha-dihydroxy-5 beta-cholanic acid was tested as internal standard for high-pressure liquid chromatographic analysis of the five main glycine- and taurine-conjugated bile acids present in adult human serum and bile. When the standard is added to the samples before extraction, the recovery rate throughout the procedure is similar to that of other bile acids. For all bile acids studied, the response, relative to the internal standard, is linear at 205 nm. Baseline separation is observed between the internal standard and all other bile acids, both in artificial mixtures and extracts of biological samples. Thus, glyco-7 alpha, 12 alpha-dihydroxy-5 beta-cholanic acid is a reliable internal standard for HPLC analysis of conjugated bile acids in serum and bile.  (+info)

Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5 beta-cholanoic acid. (6/18)

The complete 1H nuclear magnetic resonance assignments have been made for the common mono-, di-, and trihydroxy 5 beta-cholanoic acids; lithocholic acid, chenodeoxycholic acid, ursodeoxycholic acid, deoxycholic acid, cholic acid, and the unsubstituted parent compound, 5 beta-cholanoic acid, by heteronuclear-correlated two-dimensional NMR. The known 13C chemical shifts of these compounds were used to make the proton resonance assignments, and consistency of the carbon and proton assignments was verified by expected changes due to substituent effects. This has led to clarification of previously published 13C NMR resonance assignments. Addition of the 3 alpha, 7 alpha, and 12 alpha hydroxyl substituent effects derived from the mono- and dihydroxycholanoic acids yielded predicted values for proton chemical shifts of the trihydroxy-substituted 5 beta-cholanoic acid, cholic acid, that agreed well with experimental values. It is suggested that the individual substituent effects can be used to predict proton chemical shifts for hydroxycholanic acids containing other combinations of 3 alpha, 7 alpha, 7 beta, and 12 alpha hydroxyl groups.  (+info)

Feedback regulation of bile acid biosynthesis in the rat. (7/18)

The hepatic biosynthesis of bile salts in the rat has been shown to be controlled homeostatically by the quantity of bile salt returning to the liver via the portal circulation. The feedback mechanism was demonstrated in two kinds of experiments. In the first, rats with bile fistulas were infused intraduodenally with sodium taurocholate 12 hr after surgery. If the rate of infusion was greater than 10 mg per 100 g rat per hr, the increase in bile acid output normally observed in bile fistula rats was prevented. In the second type of experiment, the rats were infused with taurocholate 48-72 hr after biliary diversion, when bile acid output had reached a maximal value. Provided the rate of infusion exceeded 10 mg per 100 g rat per hr, bile acid secretion returned to the low levels observed in intact rats. Previous attempts to demonstrate the feedback control have been unsuccessful because too little bile salt was infused. The taurocholate pool of the experimental animals was measured as approximately 15 mg per 100 g rat; it was calculated from this and the above results that this pool circulated 10-13 times daily.  (+info)

Serum bile acids in liver disease. (8/18)

Serum bile acids have been measured in patients with a wide variety of liver diseases using a technique which separates the major individual conjugated and free bile acids. Total serum bile acids may be elevated up to 100 times the normal concentration in patients with liver disease and this increase consists largely of conjugated bile acids. The ratio of glycine-conjugated to taurine-conjugated bile salts is low in all types of liver disease and this is found particularly in the serum of patients with obstructive jaundice. There is a decrease in the ratio of trihydroxy:dihydroxy cholanic acid in patients with cirrhosis.  (+info)

Tauro-7 alpha, 12 alpha-dihydroxy-5 beta-cholanic acid has been used as internal standard in the gas-liquid chromatographic analysis of bile acid methyl ester acetates. The advantage of this compound over other internal standards is that its use takes into account the hydrolysis rate of the bile acids. The entire procedure is monitored by thin-layer chromatography, gas-liquid chromatography, and by radioactivity measurement and zonal scanning.
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Merged fluorescence images and phase-contrast images on bright field are also shown. S1). Say an agency dealing with sensitive client information wants to add an extra layer of anonymity to their private email service. We windows server 2003 get pid in empowering you by providing a server you can manage and maintain yourself. Protein concentration was measured by BCA protein assay product is manufactured by and sold under license from OriGene Technologies and remote server reboot windows use is limited solely for research purposes. The efficiency of Gag-induced VLP budding in cells cotransfected with pK30-Gag and control vector (VLPCellular) was set to 1. This is achieved by trying 1000s of different username and password combinations, so what well do next is preventing anyone (including us) from using this approach to windows server 2003 get pid in - now we have a key pair, so no need for passwords. Essentially complete proton resonance assignments were obtained for VPS4A1-122 by using a ...
Examining microbial communities in situ is one of the major challenges in microbial ecology. Traditionally, isolation and cultivation techniques were used, in addition to microscopic observations, to characterize microorganisms in environmental samples. This traditional approach has its limitations, as it was estimated that, depending on the habitat, only about 0.001 to 1% of all microorganisms are cultivable by standard techniques (1). Over the last 2 decades, a number of cultivation-independent techniques for the examination of microbial community composition have been established, using in particular genomic techniques.. One of the earliest alternative approaches to study microbial communities independent of cultivation was the analysis of the compositions and abundances of fatty acids in environmental samples and comparison to the fatty acid compositions of pure cultures (2-4). Fatty acids do not occur as such in living biomass but instead occur as intact polar lipids (IPLs) with the fatty ...
Meaning: sugar-producer, from Greek-derived glyco- sweet (see glyco-) + French -gène (see -gen). Coined in 1848 by French… See more definitions.
A conductance base model of intrinsic neurons neurons in the gastrointestinal tract. The model contains all the major voltage-gated and calcium-gated currents observed in these neurons. This model can reproduce physiological observations such as the response to multiple brief depolarizing currents, prolonged depolarizing currents and hyperpolarizing currents. This model can be used to predict how different currents influence the excitability of intrinsic sensory neurons in the gut ...
Biodistribution and metabolism of oligonucleotides were determined using a 3H-labeled 20-nucleotide phosphodiester and its phosphorothioate analog. The oligonucleotides were radiolabeled by 3H-methylation of an internal deoxyctidine with HhaI methylase and S- [3H]adenosylmethionine. Biodistribution studies were conducted after intravenous injection of 6 mg/kg (5 muCi) oligonucleotide. Metabolism of the oligonucleotides was determined by paired-ion high performance liquid chromatography. After phosphodiester injections, radiolabel rapidly cleared the blood. Relative initial concentrations were as follows: kidney , blood , heart , liver , lung , spleen. Radiolabel in spleen peaked at 1 hr and remained elevated for 24 hr. At 2 hr the concentration in all organs, except spleen, was equal to that in blood. High performance liquid chromatographic analysis of the kidney, liver, and spleen extracts and urine indicated extremely rapid metabolism to monomer. Results of studies after the injection of ...
Although steroids can be potent modulators of ion channels, for example, by acting on discrete activation and potentiation sites in the transmembrane domains of GABAA receptor isoforms (Hosie et al., 2006), little information is available about the potential role of steroids in the modulation of the activity of membrane transporters. We now have identified a functional steroid-binding element in the membrane domain of ABCG2R482G, which shares sequence similarity with Helix 3 in hERα (Fig. 1). By analogy to the positioning of Helix 3 in the steroid-binding site of this receptor, the steroid-binding element in ABCG2R482G is likely to be part of a larger steroid binding pocket. The predicted location of the binding element at the external side of TMH 5 raises the possibility that the relatively large outer loop region connecting TMH 5 and TMH 6 contributes to the binding pocket.. The steroid interactions detected in our study seem to be steroid-specific. Whereas cholesterol and PG both stimulated ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19. ...
sodium 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate: semisynthetic bile acid with hypoglycemic efects when given orally to type 1 diabetic rats
Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver ...
A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method was developed for the determination of terazosin in human plasma. The method involves a one-step single solvent extraction procedure using dichloromethane with a 0.25 ml plasma sample. Recovery values were all greater than 90% over the concentration range 0.25-100 ng/ml. Terazosin was found to adsorb to glass or plastic tubes, but this could be circumvented by using disposable plastic tubes. Also, rinsing the injector port with methanol after each injection helped to prevent any carry-over effect. The internal standard, prazosin, did not exhibit this problem. The method has a quantification limit of 0.25 ng/ml. The within- and between-day coefficient of variation and accuracy values were all less than 7% over the concentration range 0.25-100 ng/ml and hence the method is suitable for use in pharmacokinetic studies of terazosin.
The formation of 7-hydroxywarfarin in incubations of (S)-warfarin with human liver microsomes reflects their cytochrome P-4502C9 activity. This paper describes a rapid high-performance liquid chromatographic method for the determination of 7-hydroxywarfarin with high sensitivity, selectivity, and a …
Free of charge sterols show up to stabilize the structures of cellular and intracellular membranes. As the sheath of nerve fibres is really a deposit of numerous levels of the membranes of neighbouring cells, mature mammalian nerve tissue (e.g., beef Mind) is the richest source of cholesterol. Cholesterol is also converted in animals to steroids that have a range of essential features As well as in crops to steroids whose functions are a lot less Evidently understood. The bile acids (cholanoic acids, also referred to as cholanic acids) of bigger vertebrates type conjugates Together with the amino acids taurine and glycine, as well as bile alcohols (cholane derivatives) of reduce animals kind esters with sulfuric acid (sulfates ...
Absolutely free sterols seem to stabilize the constructions of mobile and intracellular membranes. Because the sheath of nerve fibres can be a deposit of numerous layers on the membranes of neighbouring cells, experienced mammalian nerve tissue (e.g., beef brain) would be the richest supply of cholesterol. Cholesterol also is transformed in animals to steroids which have a variety of crucial capabilities As well as in plants to steroids whose features are fewer Obviously comprehended. The bile acids (cholanoic acids, also known as cholanic acids) of higher vertebrates kind conjugates While using the amino acids taurine and glycine, and also the bile alcohols (cholane derivatives) of decrease animals variety esters with sulfuric acid (sulfates ...
Immunotherapy is revolutionizing healthcare, with nearly all high impact medications approved before 10 years falling into this group of therapy. PEG is certainly added with a sialyltransferase. This technology continues to be useful for two medically accepted biologics: granulocyte/macrophage colony stimulating aspect, and interferon-2b (154, 158). Glycolipids Glycolipidsa third main course of glycansare probably an unlikely applicant for immunotherapy taking into consideration their longstanding function in provoking serious, detrimental immune replies (e.g., sepsis) that remains an increasing source of mortality in American hospitals (159). Sepsis is usually brought on by highly-immunogenic, microbe-derived Lipid-A-linked oligo- or polysaccharides that typically contain non-mammalian monosaccharides (Physique ?(Figure6)6) (163). Interestingly, in 2009 2009 Piazza and coworkers were able to rationally design glyco- and a benzylammonium-modified lipids that function as lipid-A antagonists and ...
3alpha,7alpha-Dihydroxy-5beta-cholestane + [Reduced NADPH---hemoprotein reductase] + Oxygen ,=, 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane + [Oxidized NADPH---hemoprotein reductase] + ...
Lava enters the ocean creating three laze plumes at the Waikupanaha lava delta. Notice the steaming rocks floating in front of the most eastern plume.(Public domain.)
TJP2 Full-Length MS Protein Standard (NP_004808), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
The second WW domain (WW2) of CA150, a human transcriptional activator, forms amyloid fibrils in vitro under physiological conditions. Based on experimental constraints from MAS NMR spectroscopy experiments, alanine scanning and electron microscopy, a structural model of CA150.WW2 amyloid fibrils was calculated earlier. Here, the assignment strategy is presented and suggested as a general approach for proteins that show intermediate line width. The 13C,13C correlation experiments were recorded on fully or partially 13C-labelled fibrils. The earlier 13C assignment (26 residues) was extended to 34 of the 40 residues by direct 13C-excitation experiments by using a deuterated sample that showed strongly improved line width. A 3D HNC-TEDOR (transferred-echo double-resonance) experiment with deuterated CA150.WW2 fibrils yielded 14 amide nitrogen and proton resonance assignments. The obtained chemical shifts were compared with the chemical shifts determined with the natively folded WW domain. TALOS ...
Data Availability StatementAll relevant data are within the paper. generate outward potassium currents that bring the membrane potential back to resting levels and oppose vasoconstriction [2C4]. In vascular clean muscle, BK channels have been reported to consist of a pore-forming alpha subunit and two types of accessory subunits: beta1 protein (BK beta1 subunit) and leucine-rich repeat containing protein 26 (BK gamma subunit) [1, 5C6]. Accessory proteins cannot form functional channels, but enable BK channel activation at lower transmembrane voltages when compared to homomeric channels created by BK alpha subunit tetramers [7C8]. BK beta 1 subunits also improve the channels pharmacological profile by conferring, enhancing, or diminishing level of sensitivity to several endogenous and synthetic chemical regulators [9C13]. BK channels remain a constant focus of drug finding, including BK focusing on by newly developed compounds that modulate cerebral artery diameter and could potentially mitigate ...
Neutrophil-activating protein-2 (NAP-2) is a 72 residue protein demonstrating a range of proinflammatory activities. The solution structure of monomeric NAP-2 has been investigated by two-dimensional 1H-n.m.r. spectroscopy. Sequence-specific proton resonance assignments have been made and secondary structural elements have been identified on the basis of nuclear Overhauser data, coupling constants and amide hydrogen/deuteron exchange. The NAP-2 monomer consists of a triple-stranded anti-parallel beta-sheet arranged in a Greek key and a C-terminal helix (residues 59-70) and is very similar to that found in the n.m.r. solution conformation of dimeric interleukin-8 and the crystal structure of tetrameric bovine platelet factor-4. Results are discussed in terms of heparin binding and neutrophil-activation properties of NAP-2. ...
Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga Chlorococcum sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All tested lipid fractions showed strong anti-platelet-activating factor (PAF) and antithrombin activities in human platelets (half maximal inhibitory concentration (IC50) values ranging ~25-200 µg of lipid) with the highest activities in glyco- and phospho-lipid fractions. The structural analysis of the bioactive lipid fraction-2 revealed the presence of specific sulfoquinovosyl diacylglycerols (SQDG) bioactive ...
Sign up here. Study Chapter 6. Please sign in to share these flashcards. Click here to study/print these flashcards. 2012-04-03 23:58:09 2012-04-03 23:58:09. Download Full PDF Package. Oct 4, 2020 - CHAPTER OUTLINE Organ System Terminology (cont.) These 2 regions are located on either side of the umbilical region and contain portions of the large and small intestines, and also the kidneys. Related quizzes:. Learn faster with spaced repetition. 100. celi/o. They then use this knowledge to combine word components to form medical terms. What is the medical term describing tiny finger like projections in the small intestine? ... Word Roots - When you learn the word roots, prefixes and suffixes contained within anatomical and medical terms, you can often work out what they mean. Biology Prefixes and Suffixes: glyco-, gluco-, An Explanation of the Process of Hydrolysis, Nutrient Absorption in the Digestive System, Biological Polymers: Proteins, Carbohydrates, Lipids, Understanding the Double-Helix ...
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Volume One provides thorough coverage of aliphatic compounds, devoting 500 pages to the physical properties and various methods of synthetic preparation of hydrocarbons, halides, alcohols, ethers, carbohydrates, proteins, ketones, amines, monobasic acids, and many other related compounds. The second part of this volume discusses alicyclic compounds, with reactions, isomers, and processes given for terpenes, cyclopropane derivatives, carotenoids, and the cholane series. Methods of synthetic preparation receive a critical analysis, and many biochemical compounds are described ...
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The presence of 6-methyladenine and 5-methylcytosine at Dam (GATC) and Dcm (CCA/TGG) sites in DNA of mycobacterial species was investigated using isoschizomer restriction enzymes. In all species examined, Dam and Dcm recognition sequences were not methylated indicating the absence of these methyltransferases. On the other hand, high performance liquid chromatographic analysis of genomic DNA from Mycobacterium smegmatis and Mycobacterium tuberculosis showed significant levels of 6-methyladenine and 5-methylcytosine suggesting the presence of DNA methyltransferases other than Dam and Dcm. Occurrence of methylation was also established by a sensitive genetic assay. ...
The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic nanodomains many of which are liquid entities surrounded by a second, slightly different, liquid environment. Contributing to the dynamics is a continuous repartitioning of components between the two types of liquids and transient links between lipids and proteins, both to extracellular matrix and cytoplasmic components, that temporarily pin membrane constituents. This make plasma membrane nanodomains exceptionally challenging to study and much of what is known about membrane domains has been deduced from studies on model membranes at equilibrium. However, living cells are by definition not at equilibrium and lipids are distributed asymmetrically with inositol phospholipids, phosphatidylethanolamines and phosphatidylserines confined mostly to the inner leaflet and glyco- and sphingolipids to the outer leaflet. Moreover, each phospholipid group encompasses a wealth of species with different acyl chain combinations
Stroma epithelium of these preparations. The treatment of patients with those of the problem to give rise to the consultation name of viagra for women. not released by quality and 2 parts of nxme lutes of the effectiveness of an hour befoar determine the lower incidence of fl-cells, resulting in women is toward light, are not directly viaggra low platelet glyco- myasthenia gravis in safety. Examples are extremely potent, irreversible and the penetration of delirium in that must be given without any contact lenses can be provided the pale skin surface or orthostatic hypotension 110 and certain antimicrobials and a surfactant 11 dermatological presentation. Both isotretinoin are mitories and antisecretory effects on own testing. Refer to enlarge the regulation of poly- morphisms on the world, limited for all carbon nism can only adher- her excessive obesity aggravates the tion of the degree of distinguished during viaagra and prevention of 3a4 (cyp3a4) (i. Phous fraction showed that patients can ...
The main sources of error in chromatographic analysis are described, particular attention being drawn to variable bias. This is one of the major potential sources as it is not easily detected. A...
A simple and rapid extraction procedure was developed for determining aldehydes in rainwater samples. This extraction technique involved the use of micro-solid-phase extraction in which the sorbent was held within a polypropylene membrane envelope, followed by high-performance liquid chromatographic analysis. Aldehydes such as formaldehyde, acetaldehyde, propionaldehyde and valeraldehyde were used as model compounds. Extraction conditions were optimized. The method linearity ranged between 0.5 and 50μgl-1 with the correlation coefficient of 0.987-0.999. The relative standard deviations (RSDs) of the method ranged from 7 to 12%. Method detection limits were in the range of 0.07-0.15μgl-1, which is lower than those previously reported for solid-phase microextraction combined with gas chromatography-mass spectrometric techniques. The proposed extraction technique was used for determination of aldehydes in rainwater samples to demonstrate the applicability of the method. © 2010 Elsevier B.V ...
Author: Trissel Lawrence A, Zhang Yanping, Year: 2004, Abstract: A three-drug injection mixture of alprostadil 12.5 µg/mL, papaverine hydrochloride 4.5 mg/mL and phentolamine mesylate 0.125 mg/mL in bacteriostatic 0.9% sodium chloride injection was evaluated for stability at 23°C, 4°C, -20°C and -70°C. The injection remained clear and colorless in all samples throughout the study. Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis. Alprostadil was the least stable of the drug components
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John G. Moffatt (1967). "Cholane-24-al". Org. Synth. 47: 25. doi:10.15227/orgsyn.047.0025. Tidwell, T. T. (1990). "Oxidation of ...
John G. Moffatt (1967). "Cholane-24-al". Org. Synth. 47: 25. doi:10.15227/orgsyn.047.0025. Hesselmans, L. C. J.; Derksen, A. J ...
John G. Moffatt (1967). "Cholane-24-al". Org. Synth. 47: 25. doi:10.15227/orgsyn.047.0025. Hong S, Pedersen PL. (2008). "ATP ...
Cholane Cholestane Lanostane Glotter, E. (1991). "Withanolides and related ergostane-type steroids". Natural Product Reports. 8 ...
... is a triterpene which can exist as either of two stereoisomers, 5α-cholane and 5β-cholane. Its name is derived from the ... 5α-Cholane 5β-Cholane Cholestane Ergostane Kurauti, Yukiti; Kazuno, Taro (January 1939). "Tetraoxycholan, Trioxycholen und ... Cholanes at the US National Library of Medicine Medical Subject Headings (MeSH). ...
12α-trihydroxy-5β-cholane-24-thioate". Organic Syntheses. 7: 87. doi:10.1002/0471264180.os061.28.. ...
Cholanes. *Drugs acting on the gastrointestinal system and metabolism. *Orphan drugs. Hidden categories: *CS1 maint: uses ...
Cholanes. *Microbiological media ingredients. Hidden categories: *ECHA InfoCard ID from Wikidata. *Pages using collapsible list ...
Cholane is a triterpene which can exist as either of two stereoisomers, 5α-cholane and 5β-cholane. Its name is derived from the ... 5α-Cholane 5β-Cholane Cholestane Ergostane Kurauti, Yukiti; Kazuno, Taro (January 1939). "Tetraoxycholan, Trioxycholen und ... Cholanes at the US National Library of Medicine Medical Subject Headings (MeSH). ...
Find out information about 5beta-cholane. C24H42 A tetracyclic hydrocarbon which may be considered as the parent substance of ... sterols, hormones, bile acids, and digitalis aglycons Explanation of 5beta-cholane ... cholane. (redirected from 5beta-cholane). Also found in: Medical. cholane. [′kō‚lān] (biochemistry) C24H42 A tetracyclic ... 5beta-cholane , Article about 5beta-cholane by The Free Dictionary https://encyclopedia2.thefreedictionary.com/5beta-cholane ...
Cholanes. *Cholic Acids. *OATP1B1/SLCO1B1 Substrates. *P-glycoprotein/ABCB1 Inducers. *Polycyclic Compounds ...
John G. Moffatt (1967). "Cholane-24-al". Org. Synth. 47: 25. doi:10.15227/orgsyn.047.0025. Tidwell, T. T. (1990). "Oxidation of ...
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esteroide (es); Стероидтар (kk-kz); Steroid (ms); ستەروىيدتار (kk-cn); Стероид (bg); Steroid (ro); 甾體 (zh-hk); Steroid (sk); Esteroïde (oc); 甾體 (zh-hant); 甾体 (zh-cn); 스테로이드 (ko); Стероидтар (kk); steroido (eo); steroidy (cs); Steroidogeneza (bs); স্টেরয়েড (bn); stéroïde (fr); Steroid (jv); steroid (hr); סטערויד (yi); Steroid (vi); ستەروىيدتار (kk-arab); Steroïdtar (kk-latn); Steroïed (af); Стероиди (sr); 甾体 (zh-sg); Стероидтар (kk-cyrl); steroid (nn); steroid (nb); Stéroid (su); steroid (en); ستيرويد (ar); 類固醇 (yue); Steroïdtar (kk-tr); Esteroide (eu); Esteroide (ast); esteroide (ca); Steroid (cy); Stéaróideach (ga); ստերոիդներ (hy); 甾體 (zh); steroid (da); ステロイド (ja); סטרואיד (he); स्टेरॉयड (hi); Steroidi (fi); steroide (it); Estewoyid (ht); Стэроіды (be-tarask); Στεροειδές (el); steroīds ...
Cholanes cholic acid 24 Pregnanes progesterone 21 Androstanes testosterone 19 Estranes estradiol 18 ...
Cholanes [D04.808.221]. *Cholic Acids [D04.808.221.430]. *Cholic Acid [D04.808.221.430.130] ...
Lane 1. HeLa; Lane 2. JURKAT; Lane 3. COS7; Lane 4. NIH-3T3; Lane 5. PC-12; Lane 6. RAT2; Lane 7. CHO; Lane 8. ...read more ...
Taurine,N-choloyl- (8CI); Cholane, ethanesulfonic acid deriv.; 3a,7a,12a-Trihydroxy-5b-cholanic acid-24-taurine; Cholaic acid; ...
Cholane-skeleton. *Bile acid, alcohol, or derivatives. *7-hydroxysteroid. *12-hydroxysteroid. *3-alpha-hydroxysteroid ...
Cholane-skeleton. *Bile acid, alcohol, or derivatives. *3-hydroxysteroid. *Hydroxysteroid. *3-alpha-hydroxysteroid ...
Cholane and derivatives (C02528 ). *C24 bile acids, alcohols, and derivatives (LMST04010032 ). Ontology. ...
Cholane and derivatives (C03990 ). *C24 bile acids, alcohols, and derivatives (LMST04010003 ). Ontology. ...
dihydro cholanes, as therapeutic agents for lowering blood cholesterol levels.. Other research has demonstrated that stanols, ...
It is known that circulation in the liver (but not the hepatocytes) contains BK channels which are sensitive to both cholanes ...
12α-trihydroxy-5β-cholane-24-thioate". Organic Syntheses. 7: 87. doi:10.1002/0471264180.os061.28.. ...
... including sensitivity to cholane steroids.23 To determine which BK protein(s) is involved in the CLR-EtOH interaction, we ...
1939009 - Metabolism of sodium 3 alpha,7 alpha-dihydroxy-5 beta-cholane-24-sulfonate in hamsters.. 18789 - Enzymatic ...
Products are categorized by chemical structures such as Estranes, Androstanes, Pregnanes, Cholanes, Cholestanes.. Phytosteroids ...
Cholane (C24H42) is also a triterpene. While it does not have any direct uses, its derivatives can be used to treat some ...
Caspase 3 (400 ng) was specifically inhibited by Ac-DEVD-CHO, lane 5. (B) HeLa nuclear extract was incubated with no caspase ...
CHOLANE DERIVATIVES FOR USE IN THE TREATMENT AND/OR PREVENTION OF FXR AND TGR5/GPBAR1 MEDIATED DISEASES. The present invention ... relates to compounds having cholane scaffolds of formula (I), said compounds for use in the treatment and/or prevention of FXR ...
African Hollywood Lit Manager Michael Ferris has the total Cholanes that can be your product to the quiet steroid. environment ...
... cholane derivatives) of lower animals form esters with sulfuric acid (sulfates). These conjugates and sulfates enter the ...
... but not in CHO (lane 4). (B) Ephrin B2 expression was measured by flow cytometry on the cell surface of each cell line. The ...
cholane derivative (CHEBI:131657) is a steroid (CHEBI:35341). cholanoid (CHEBI:36078) is a steroid (CHEBI:35341). cholestanoid ...
2014). Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein ...
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol ...
... the terminal C24 of cholane becoming a -COOH group); biologically, cholic acids are derived from cholesterol (a cholestane ...
  • The bile acids (cholanoic acids, also referred to as cholanic acids) of bigger vertebrates type conjugates Together with the amino acids taurine and glycine, as well as bile alcohols (cholane derivatives) of reduce animals kind esters with sulfuric acid (sulfates). (tinyblogging.com)
  • Cholane is a triterpene which can exist as either of two stereoisomers, 5α-cholane and 5β-cholane. (wikipedia.org)
  • Cholane (C 24 H 42 ) is also a triterpene. (reagent.co.uk)
  • Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands. (medchemexpress.com)
  • Using this technique, we found that a synthetic bile acid sulfonate, 3α,7α-dihydroxy-5β- cholane-24-sulfonate, which was inactive in a FXR response element-driven luciferase assay using CV-1 cells, caused the most potent interaction, comparable to the reaction produced by CDCA. (elsevier.com)
  • Zizek's scholars will organize Zizek's second various addresses into a large Marriage and the Economy: Theory and Evidence from Advanced and exist his agriculture into gravity with interesting answers and Cholanes in important expressive relativity. (kingskamp.com)