Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.Diuretics: Agents that promote the excretion of urine through their effects on kidney function.Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.Sodium Chloride Symporter Inhibitors: Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Lisinopril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Tetrahydropapaveroline: A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.Benzoin: A white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide and used in organic syntheses. This should not be confused with benzoin gum from STYRAX.Bendroflumethiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Blood Pressure Determination: Techniques for measuring blood pressure.Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Physician-Patient Relations: The interactions between physician and patient.OxadiazolesUnited States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.Health Resources: Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.Resource Allocation: Societal or individual decisions about the equitable distribution of available resources.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Symptom Assessment: Evaluation of manifestations of disease.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Betaxolol: A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.Levobunolol: The L-Isomer of bunolol.Accreditation: Certification as complying with a standard set by non-governmental organizations, applied for by institutions, programs, and facilities on a voluntary basis.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Joint Commission on Accreditation of Healthcare Organizations: A private, voluntary, not-for-profit organization which establishes standards for the operation of health facilities and services, conducts surveys, and awards accreditation.MarylandClonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.Consumer Health Information: Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Mites: Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.Mite Infestations: Infestations with arthropods of the subclass ACARI, superorder Acariformes.Matrilin Proteins: PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.Cartilage Oligomeric Matrix Protein: Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Library Services: Services offered to the library user. They include reference and circulation.Libraries, MedicalDirectories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Directory

Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. (1/89)

The treatment of hypertension with high-dose thiazide diuretics results in potassium depletion and a limited benefit for preventing coronary events. The clinical relevance of hypokalemia associated with low-dose diuretics has not been assessed. To determine whether hypokalemia that occurs with low-dose diuretics is associated with a reduced benefit on cardiovascular events, we analyzed data of 4126 participants in the Systolic Hypertension in the Elderly Program (SHEP), a 5-year randomized, placebo-controlled clinical trial of chlorthalidone-based treatment of isolated systolic hypertension in older persons. After 1 year of treatment, 7.2% of the participants randomized to active treatment had a serum potassium <3.5 mmol/L compared with 1% of the participants randomized to placebo (P<0.001). During the 4 years after the first annual visit, 451 participants experienced a cardiovascular event, 215 experienced a coronary event, 177 experienced stroke, and 323 died. After adjustment for known risk factors and study drug dose, the participants who received active treatment and who experienced hypokalemia had a similar risk of cardiovascular events, coronary events, and stroke as those randomized to placebo. Within the active treatment group, the risk of these events was 51%, 55%, and 72% lower, respectively, among those who had normal serum potassium levels compared with those who experienced hypokalemia (P<0.05). The participants who had hypokalemia after 1 year of treatment with a low-dose diuretic did not experience the reduction in cardiovascular events achieved among those who did not have hypokalemia.  (+info)

Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate. (2/89)

Chlorthalidone given to 40 hypertensive women significantly decreased blood pressure and serum potassium levels and increased the serum urate concentration. There were no individual correlations between the reduction in blood pressure and the decrease in serum potassium or the increase in serum urate. A reduction in dosage from 50 mg daily to 50 mg three times a week produced no significant changes in the diastolic or mean blood pressures though the systolic blood pressure was moderately increased. Concomitantly, serum potassium increased and serum urate decreased significantly on the lower chlorthalidone dose. We conclude that high doses of oral diuretics compared with lower ones are of limited further benefit and may increase the risk of clinically significant hypokalaemia and hyperuricaemia.  (+info)

Dementia and disability outcomes in large hypertension trials: lessons learned from the systolic hypertension in the elderly program (SHEP) trial. (3/89)

In the Systolic Hypertension in the Elderly Program (SHEP) trial (1985-1990), active treatment reduced the incidence of cardiovascular events, but not that of dementia and disability, as compared with placebo. This study aims to evaluate if assessment of cognitive and functional outcomes was biased by differential dropout. Characteristics of subjects who did or did not participate in follow-up cognitive and functional evaluations were compared. The relative risks of incident cognitive impairment and disability were assessed in the two treatment groups, with the use of the reported findings and under the assumption that the proportions of cognitive and functional impairment among dropouts increased. Assignment to the placebo group and the occurrence of cardiovascular events independently predicted missed assessments. From the reported findings, the risk of cognitive and functional impairment was similar between the two treatment groups. However, when 20-30% and 40-80% of the subjects who missed the assessment were assumed to be cognitively and, respectively, functionally impaired, assignment to active treatment reduced the risk of these outcomes. In the SHEP, the cognitive and functional evaluations were biased toward the null effect by differential dropout. This might have obscured the appraisal of a protective effect of treatment on the cognitive and functional decline of older hypertensive adults.  (+info)

Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease. (4/89)

OBJECTIVE: Antihypertensive therapy with thiazides decreases coronary events in elderly patients. However, the influence of diuretics on myocardial ischemia has not been fully investigated. The aim of this study was to compare the effect of chlorthalidone and diltiazem on myocardial ischemia. METHODS: Following a randomized, double-blind, crossover protocol, we studied 15 elderly hypertensive patients aged 73.6+/-4.6 years with myocardial ischemia. All patients had angiographically documented coronary artery disease. We measured patients using 48- hour ambulatory electrocardiogram monitoring and exercise testing. After a 2-week period using placebo, patients received chlorthalidone or diltiazem for 4 weeks. RESULTS: Both treatments lowered systolic and diastolic blood pressures. The number of ischemic episodes on ambulatory electrocardiogram recordings was reduced with the use of chlorthalidone (2.5+/-3.8) and diltiazem (3.2+/-4.2) when compared with placebo (7.9+/-8.8; p<0.05). The total duration of ischemic episodes was reduced in both treatments when compared with placebo (chlorthalidone: 19.2+/-31.9min; diltiazem: 19.3+/-29.6min; placebo: 46.1+/-55.3min; p<0.05). CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem. This result is consistent with epidemiological studies and suggests that reduction of arterial blood pressure with thiazide therapy plays an important role in decreasing myocardial ischemia.  (+info)

Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. (5/89)

BACKGROUND: Although present guidelines suggest that treatment of hypertension is more effective in patients with multiple risk factors and higher risk of cardiovascular events, this hypothesis was never verified in older patients with systolic hypertension. METHODS AND RESULTS: Using data from the Systolic Hypertension in the Elderly Program, we calculated the global cardiovascular risk score according to the American Heart Association Multiple Risk Factor Assessment Equation in 4,189 participants free of cardiovascular disease (CVD) and in 264 participants with CVD at baseline. In the placebo group, rates of cardiovascular events over 4.5 years were progressively higher according to higher quartiles of CVD risk. The protection conferred by treatment was similar across quartiles of risk. However, the numbers needed to treat (NNTs) to prevent one cardiovascular event were progressively smaller according to higher cardiovascular risk quartiles. In participants with baseline CVD, the NNTs to prevent one cardiovascular event were similar to those estimated for CVD-free participants in the highest-risk quartile. CONCLUSIONS: Treatment of systolic hypertension is most effective in older patients who, because of additional risk factors or prevalent CVD, are at higher risk of developing a cardiovascular event. These patients are prime candidates for antihypertensive treatment.  (+info)

Functional differences between flounder and rat thiazide-sensitive Na-Cl cotransporter. (6/89)

The purpose of the present study was to determine the major functional, pharmacological, and regulatory properties of the flounder thiazide-sensitive Na-Cl cotransporter (flTSC) to make a direct comparison with our recent characterization of the rat TSC (rTSC; Monroy A, Plata C, Hebert SC, and Gamba G. Am J Physiol Renal Physiol 279: F161-F169, 2000). When expressed in Xenopus laevis oocytes, flTSC exhibits lower affinity for Na(+) than for Cl(-), with apparent Michaelis-Menten constant (K(m)) values of 58.2 +/- 7.1 and 22.1 +/- 4.2 mM, respectively. These K(m) values are significantly higher than those observed in rTSC. The Na(+) and Cl(-) affinities decreased when the concentration of the counterion was lowered, suggesting that the binding of one ion increases the affinity of the transporter for the other. The effect of several thiazides on flTSC function was biphasic. Low concentrations of thiazides (10(-9) to 10(-7) M) resulted in activation of the cotransporter, whereas higher concentrations (10(-6) to 10(-4) M) were inhibitory. In rTSC, this biphasic effect was observed only with chlorthalidone. The affinity for thiazides in flTSC was lower than in rTSC, but the affinity in flTSC was not affected by the Na(+) or the Cl(-) concentration in the uptake medium. In addition to thiazides, flTSC and rTSC were inhibited by Hg(2+), with an apparent higher affinity for rTSC. Finally, flTSC function was decreased by activation of protein kinase C with phorbol esters and by hypertonicity. In summary, we have found significant regulatory, kinetic, and pharmacological differences between flTSC and rTSC orthologues.  (+info)

Responsiveness of hypercalciuria to thiazide in Dent's disease. (7/89)

Hypercalciuria is the major risk factor promoting stone formation in Dent's disease, also known as X-linked recessive nephrolithiasis, but the effects of diuretics on calcium excretion and other stone risk factors in this disease are unknown. This study examined urine composition in eight male patients with Dent's disease, ages 6 to 49 yr, all of whom were hypercalciuric and had inactivating mutations of CLCN5. Eight males, ages 7 to 34 yr, with idiopathic hypercalciuria (IH) served as controls. Patients were instructed to maintain a consistent intake of sodium, potassium, calcium, and protein. Two consecutive 24-h urine collections were obtained after a baseline period and after 2 wk of chlorthalidone (25 mg), amiloride (5 mg), and the two diuretics in combination, with a week off drug separating the treatment periods in a randomized crossover design. Doses were reduced by half in boys under age 12 yr. Chlorthalidone alone (P < 0.002) and the combination of chlorthalidone and amiloride (P < 0.003) reduced calcium excretion significantly in either patient group. With chlorthalidone, calcium excretion fell to normal (<4.0 mg/kg per d) in all but one patient in each group. Amiloride alone had no significant effect on urinary calcium excretion, in either patient group. In patients with Dent's disease during chlorthalidone therapy, the supersaturation ratios for calcium oxalate and calcium phosphate fell by 25% and 35%, respectively. Mean citrate excretion was reduced by chlorthalidone (P <.04) and by chlorthalidone in combination with amiloride (P <.02). There were no significant differences in the responses to these diuretics between the patient groups in any of the urinary parameters. The intact hypocalciuric response to a thiazide diuretic indicates that inactivation of the ClC-5 chloride channel does not impair calcium transport in the distal convoluted tubule and indicates that thiazides should be useful in reducing the risk of kidney stone recurrence in patients with Dent's disease.  (+info)

Effects of four antihypertensive monotherapies on cardiac mass and function in hypertensive patients with left ventricular hypertrophy: randomized prospective study. (8/89)

AIM: To compare the effects of four antihypertensive drugs, which have reportedly different effectiveness in reducing myocardial mass. METHODS: A randomized, double-blind, prospective study included 80 hypertensive patients with left ventricular (LV) hypertrophy confirmed both electrocardiographically and echocardiographically. We investigated the effects of indapamide, nicardipine, propranolol, and chlorthalidone on arterial blood pressure and LV mass and function. RESULTS: Sixty-four patients (34 men and 30 women) completed the 6-month study. No significant differences in antihypertensive effects of the four medications were found. The average decrease in systolic and diastolic blood pressure was 12.8% and 10.4%, respectively. All four antihypertensive medications caused pronounced reduction in LV mass, between 7.9% in the propranolol group and 10.1% in the nicardipine group, with no significant difference between the groups. In patients receiving diuretics, predominant decrease was observed in LV mass and LV mass index. In patients treated with propranolol, the thickness of both the LV wall and interventricular septum was reduced, whereas the reduction in LV mass, LV wall and interventricular septum thickness was found in patients treated with nicardipine. There was no significant correlation between the changes in LV mass and other variables (blood pressure, and systolic and diastolic function). Systolic function did not improve with the reversion of LV hypertrophy in any group of patients, but improvement was observed in some indices of diastolic function. The early and late LV filling velocity and their ratio did not improve significantly, either. Clinically relevant side effects were not observed. CONCLUSION: All four antihypertensive monotherapies achieved a comparable control of hypertension and reduction in LV hypertrophy.  (+info)

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FROM PR NEWSWIRE DALLAS 888-776-3971/. STK. IN HEA PHA MTC. SU PDT. TO BUSINESS, HEALTH, AND MEDICAL EDITORS:. EDARBYCLOR (azilsartan medoxomil and chlorthalidone) Now Available in. U.S. Pharmacies for Patients with Hypertension. DEERFIELD, Ill., and OSAKA, Japan, Feb. 6, 2012 /PRNewswire/ -- Takeda. Pharmaceutical Company Limited (Takeda) and its wholly-owned. subsidiary, Takeda Pharmaceuticals U.S.A., Inc., today announced. EDARBYCLOR (azilsartan medoxomil and chlorthalidone) is now available. by prescription in U.S. pharmacies for the treatment of hypertension. to lower blood pressure in adults. It is the only fixed-dose therapy. in the U.S. to combine an angiotensin II receptor blocker (ARB) with. chlorthalidone in a once-daily, single tablet. In a phase 3 clinical. trial, the systolic blood pressure reductions of the maximum dose of. EDARBYCLOR (40/25 mg), by both clinic and trough 24-hour ambulatory. blood pressure monitoring, were shown to be statistically superior to. those of the ...
The antihypertensive effect of atenolol, with and without chlorthalidone, on hypertension was assessed in an outpatient as well as in an inpatient study. In the outpatient study atenolol alone induced decreases in systolic and diastolic BP amounting to 20 and 15 mm Hg. Maximal response of BP and HR developed within a week at the lowest dose used (100 mg twice daily). Combined atenolol-chlorthalidone treatment decreased lying and standing systolic BP by 7 and 14 mm Hg more than atenolol alone, but diastolic BP was decreased little more. In the inpatient study the addition of atenolol to chlorthalidone therapy in a dose of 100 mg twice daily resulted in a maximal decrease in BP within 3 days. At this dose PRA was lowered only slightly. Larger doses did not lead to any significant further decrease in BP, whereas PRA fell progressively. Our results indicate that, in contrast to nonselective blockade, specific beta-1-adrenoceptor blockade by atenolol is capable of inducing a distinct antihypertensive effect,
Early cardiovascular (CV) outcome trials of patients with hypertension used high-dose thiazide diuretic agents, often 100 mg of hydrochlorothiazide or 50 to 100 mg of chlorthalidone (1-4). Although these studies showed consistently greater CV risk reduction versus placebo, the MRFIT (Multiple Risk Factor Intervention Trial) study, which used both hydrochlorothiazide (HCTZ) and chlorthalidone, noted a greater reduction in CV events in the chlorthalidone arm, such that all participants were eventually transitioned to this agent. Retrospective analysis subsequently confirmed that there were fewer CV events in those treated with chlorthalidone (5). A recent analysis of smaller studies demonstrated that chlorthalidone is more potent than HCTZ, resulting in a larger antihypertensive effect, but also in more hypokalemia (6).. Further differences between agents comes from ambulatory blood pressure monitoring (ABPM) data showing that chlorthalidone has preserved antihypertensive effects beyond 24 h, ...
HPLC Application #24499: Chiral Separation of Chlorthalidone on Lux 5µm i-Amylose-1 in NP. Column used: Lux® 5 µm i-Amylose-1, LC Column 250 x 4.6 mm, Ea Part#: 00G-4762-E0
Atenolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Atenolol and chlorthalidone is a combination medicine used to...
Atenolol and Chlorthalidone Actavis is a medicine available in a number of countries worldwide. A list of US medications equivalent to Atenolol and Chlorthalidone Actavis is available on the Drugs.com website.
View drug interactions between azilsartan medoxomil and azilsartan medoxomil / chlorthalidone. These medicines may also interact with certain foods or diseases.
According to the World Health Organization, hypertension is the most common attributable cause of preventable death in developed nations, as uncontrolled hypertension greatly increases the risk of cardiovascular disease, cerebrovascular disease, and renal failure. Despite the availability of antihypertensive agents, hypertension remains inadequately controlled; only about one-third of patients continue to maintain control successfully.. Although most antihypertensive agents are effective at the appropriate dose, the majority have side effects that limit their use. As a class, angiotensin II receptor blockers generally are considered more tolerable than other classes of antihypertensive agents. TAK-491 (azilsartan medoxomil) is an angiotensin II receptor blocker being evaluated by Takeda to treat essential hypertension.. Treatments for essential hypertension commonly include use of a thiazide-like diuretic, either alone or as part of combination treatment. Although chlorthalidone was commonly ...
Thiazide diuretics are underused in the treatment of hypertension, despite their proven superiority.1,2 The most common thiazide used in the United States is hydrochlorothiazide (HCTZ) at a dose of 12.5 to 25 mg per day. Chlorthalidone (Thalitone; brand available as 15-mg tablet only) is a thiazide-like diuretic that is used infrequently, even though it is available as a generic, is inexpensive, and has been used as the prototype diuretic in most of the randomized controlled clinical trials during the past three decades that established the effectiveness and superiority of thiazides or thiazide-like diuretics for the treatment of hypertension. Chlorthalidone was used in the landmark SHEP study3at a dose of 12.5 to 25 mg daily, and the large Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT)1 used a similar dose for it. In the Multiple Risk Factor Intervention Trial (MRFIT), centers that used chlorthalidone had better mortality outcomes than centers that used ...
Azilsartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, azilsartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Chlorthalidone is a thiazide-like diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
The results of this study demonstrate that, in mildly hypertensive persons without evidence of underlying structural heart disease, nutritional-hygienic therapy alone is equally effective as nutritional-hygienic therapy combined with a diversity of classes of pharmacological agents in reducing LVM, with changes appearing as early as 3 months and being maintained through 4 years. Changes in LVM were nearly identical in each group, with the exception that the chlorthalidone group displayed a slightly larger mean decrease in LVM than other groups, being significantly different from placebo at 12 months. Differences at 48 months were small and nonsignificant, possibly in part because of an increased percentage of placebo participants taking active medications, often chlorthalidone. In the participants with chlorthalidone added as a second agent, the demonstration of an additional decrease in LVM further suggests an independent effect of chlorthalidone on reduction of LVM. This was not the case when ...
In spite of the existence of a great variety of treatments with drugs effective against arterial hypertension, the percentages of arterial hypertension control with monotherapy remain quite low reason why the fixed-dose combinations of drugs have been one of the most interesting research topics in order to achieve an appropriate control of arterial hypertension.. The possibility of achieving better coverage and Blood Pressure control through a drug combination has leaded, on a scientific base of the efficacy of an Angiotensin Receptor Blockers II plus diuretic combination, to the development of a great number of combinations with different Angiotensin II Receptor Blockers plus hydrochlorothiazide. Yet it is noteworthy that despite the increasing evidence showing additional benefits in Blood pressure control and reduction of cardiovascular outcomes with chlorthalidone over hydrochlorothiazide, there is neither a great number of combinations nor studies with Angiotensin II Receptor Blockers plus ...
Tenoric (Atenolol/Chlorthalidone) is an oral beta-blocker prescribed to treat patients suffering from hypertension, angina, or arrhythmias.
Learn about Tenoretic (Atenolol and Chlorthalidone) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Read the side effects of Atenolol and Chlorthalidone as described in the medical literature. In case of any doubt consult your doctor or pharmacist.
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Chlorthalidone: This medication is used to treat fluid retention (edema) occurring with congestive heart failure and disorders of the liver and kidney. It is also used alone or in combination with other medications to treat high blood pressure. It works by making the body lose excess water and salt.
I have successfully lost 100lbs over the last 2 years. I went off chlorthalidone three weeks ago and I have gained about 10 pounds while lowering my calories by 50 a day. My period and blood pressure are staying great but Im depressed and dont want to get fat again. I had been on 25 mg eve
This eMedTV segment takes a look at generic chlorthalidone. It compares the medication to Thalitone (both brand-name and any future generic versions) and lists the strengths that are available, as well as some of the companies that manufacture it.
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Ahaneku G.I., Osuji C.U., Anisiuba B.C., Ikeh V.O., Oguejiofor O.C. and Ahaneku J.E., (2011). Evaluation of blood pressure and indices of obesity in a typical rural community in eastern Nigeria. Ann. Afr. Med. 10 (2): 120-6.. Allain C.C., Poon L.S., Chain C.S.G., Richmond W,. and Fu P.C., (1974). Enzymatic etermination of the serum cholesterol. Clin. Chem. 20(4): 470-475.. Barham D. and Trinder P., (1972). Clinical guide to laboratory test. Analyst 97: 142.. Barzilay J.I., Davis B.R., Cutler J.A., Pressel S.L., Whelton P.K., Basile J., Margolis KL., Ong S.T., Sadler L.S. and Summerson J., (2006). Fasting glucose levels and incident diabetes mellitus in older non-diabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT). Ach. Intern. Med. 166(20): 2191-2201.. Benson S.C., Pershadsingh H.A., Chittiboyina A., Desai P., Pravenec M., Qi N., Wang J., Avery M.A. and ...
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position or after the first dose of this medicine. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away. Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water and which may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather. Hypokalemia (low potassium in the blood) may occur after using this medicine. Check with your doctor right away if you have any of the following symptoms: dry mouth, increased ...
Usage: This product is mainly suitable for heart, kidney, liver and other edema diseases, and combined with antihypertensive drugs, can increase the curative effect. The preparation is tablets ...
Tenoretic: This is a combination product that contains 2 medications: atenolol and chlorthalidone. It is used to treat high blood pressure. Atenolol belongs to the class of medications called beta-blockers. It works by decreasing the workload of the heart. Chlorthalidone belongs to the class of medications called diuretics (water pills). It works by getting rid of excess salt and water.
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You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks ...
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Thiazide (/ˈθaɪəzaɪd/) is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) and edema (such as that caused by heart failure, liver failure, or kidney failure). The thiazides and thiazide-like diuretics reduce the risk of death, stroke, heart attack, and heart failure due to hypertension. The class was discovered and developed at Merck and Co. in the 1950s, and the first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. In most countries, the thiazides are the cheapest antihypertensive drugs available. Regarding effectiveness in the treatment of hypertension, a systematic review by the Cochrane Collaboration found: Chlorthalidone reduces systolic and diastolic blood pressure by 12.0/4 mmHg and the reduction is not dose related when tested at a range of doses from 12.5 mg to 75 mg/day. Hydrochlorothiazides effect is dose related and at a maximum dose of 50 mg/day, the reduction is 11 ...
Using national databases, we examined mortality in the 1761 participants who developed in-trial new-onset HF requiring hospitalization, and for whom mortality data were available (,99% of the cohort). Over three quarters (77%) of the 1761 ALLHAT participants with initial HF events, fatal or requiring hospitalization, during the active, randomized phase of ALLHAT died during the extended follow-up period (mean follow-up time, 8.9 years). Mortality was high regardless of treatment group or EF category; all-cause 10-year mortality rates ranged from 83% in the chlorthalidone group to 87% in the lisinopril group. McCullough et al,20 using administrative data sets exclusively, saw similar mortality rates among patients with HF in the community. In ALLHAT HF participants, mortality, whether attributed to any cause or limited to CVD or non-CVD causes, did not differ across randomized treatment comparisons; 10-year rates were 57% to 66% for CVD and 55% to 62% for non-CVD mortality. Among those with REF, ...
Chlorthalidone 50 mg 20 Tabs is a thiazide diuretic water pill that helps prevent your body from absorbing too much salt, which can cause fluid retention. Available now at Medicines Mexico online Mexican pharmacy! Medicmex
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The link between heart failure risk and alpha blocker use was one of the findings of the landmark ALLHAT study (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). The largest antihypertensive trial to date with more than 42,000 participants, ALLHAT determined that thiazide diuretics were the preferred "first line" treatment for high blood pressure because they were the most effective at also lowering the risk of heart attack, stroke and other heart diseases. Calcium channel blockers or ACE inhibitors were recommended for patients who could not take diuretics. ALLHAT also noted that many patients need a combination of multiple antihypertensive medications ...
How Much Cost Cheapest Generic Tenoretic without prescription. Generic Tenoretic (atenolol and chlorthalidone) is used to treat people with high blood pressure. Generic Tenoretic is one of the most prescribed medications for Hypertension and has been on the market for over 25 years! Now you can order it for a fraction of its regular price! Generic Tenoretic is also marketed as Atenolol/Chlortalidone ...
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A large database study by a team including a VA investigator shows that one of the drugs frequently given to combat high blood pressure, chlorthalidone, may also improve bone strength and cut the risk of osteoporotic fractures.
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Dr. Messerli (1) made several thoughtful points in his article on the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). For example, even though a drugs effect on the risk for diabetes would not be expected to translate into short-term measurable cardiovascular events, the long-term consequences are a concern. However, taken as a whole, Messerlis essay seems to reflect his conflict-of-interest statement, in which he listed 21 companies. These companies do not make money pushing diuretics. Doctors will continue to maintain that their influence cannot be bought and that it is impolite to suggest otherwise. However, scientific evidence (2) demonstrates how subliminally fundamental to human relationships is the urge to reciprocate once a gift or kindness is extended. Annals needs to maintain a firewall. Perspectives should be written by physicians who have financial distance from the topics on which they are offering their opinions. Most of our "experts" are ...
Cainzos-Achirica, M., Martin, S. S., Cornell, J. E., Mulrow, C. D., & Guallar, E. (2015). PCSK9 Inhibitors: A New Era in Lipid-Lowering Treatment? Annals of Internal Medicine, 163(1), 64-5. DOI: 10.7326/M15-0920 ...
Adipose Stem Cell Heart Attack Trial Data Published in Journal of the American College of Cardiology; Cytoris APOLLO Trial Demonstrated Safety & Feasibility and Improvements in Cardiac Function. Cytori Therapeutics announced today the publication of previously reported six-month outcomes from APOLLO, the Companys European clinical trial evaluating adipose-derived stem and regenerative cells (ADRCs) in patients with acute myocardial infarction (heart attack or AMI), as Research Correspondence in the Journal of the American College of Cardiology. The APOLLO trial was a 14-patient, prospective, randomized, double-blind, placebo-controlled, feasibility trial (Phase I/IIA) evaluating autologous ADRCs extracted with the Companys proprietary Celution® System for ...
The idealized world of the medical student as he learns about randomized clinical trials (RCT) is one in which something like this is visualized. Lets do a RCT to find out which is the best way to treat hypertension and then we will have evidence based medicine directing our rational,quality filled medical care.. Well, the ALLHAT trial could be thought of as just such a undertaking so now we should know,right ...
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1. The pressor role of renin stimulated by chronic diuretic therapy has been assessed in 31 patients with essential hypertension by infusing the angiotensin II antagonist, saralasin, immediately before and at the end of 2 weeks treatment with the diuretic, chlorthalidone.. 2. Under diuretic therapy the change in blood pressure caused by saralasin was found to be correlated to plasma renin activity values, in such a way that small pressor responses were again observed in patients whose renin was mildly stimulated by the diuretic, whereas a marked depressor response occurred in patients whose renin was markedly increased.. 3. On the other hand, the hypotensive effect of chlorthalidone was correlated to values of plasma renin activity under diuretic therapy in an opposite direction: indeed little or no decrease and sometimes an increase in blood pressure were observed in patients with marked renin activation by diuretic therapy.. 4. It is concluded that stimulation of renin release by chronic ...
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In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol has been demonstrated by: (1) reduction in resting and exercise heart rates and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia and (4) reduction in reflex orthostatic tachycardia. A significant beta-blocking effect of atenolol, as measured by reduction of exercise tachycardia, is apparent within one hour following oral administration of a single dose. This effect is maximal at about 2 to 4 hours and persists for at least 24 hours. The effect at 24 hours is dose related and also bears a linear relationship to the logarithm of plasma atenolol concentration. However, as has been shown for all beta blocking agents, the antihypertensive effect does not appear to be related to plasma level. In normal subjects, the beta1 -selectivity of atenolol has been shown by its reduced ability to reverse the ...
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The ALLHAT blood pressure trial. The ALLHAT blood pressure trial involved more than 42,000 participants ages 55 and older. Participants had high blood pressure and at least one other risk factor for heart disease, such as cigarette smoking or type 2 diabetes. The trial was conducted at more than 600 clinics and centers across the United States and in Canada, Puerto Rico, and the U.S. Virgin Islands.. Participants were randomly assigned to receive one of the four blood pressure-lowering drugs in the study. The study was a double-blind trial, meaning that neither the researchers nor the participants knew which participants received which drug. The trial compared different medicines in patients who commonly need at least two or three medicines to control their high blood pressure. Other medicines were available to supplement the initial treatment if the participants blood pressure did not respond to the initial treatment. The study followed participants for an average of 4.9 years.. Researchers ...
Along with bromantan, which we just talked about, diuretics have long served as a way to mask steroid use. A diuretic is any drug that affects kidney function, resulting in increased urine output. The water pill chlorthalidone, for example, prevents fluids and salts from being reabsorbed into the kidney tubules and returned to the blood. As a result, more water leaves the body. Acetazolamide works by blocking the uptake of sodium bicarbonate in the kidney tubules. Upon excretion, the bicarbonate ion carries out water, sodium and potassium.. In patients with certain conditions, such as heart disease, diuretics can help control high blood pressure and fluid retention. But athletes who take anabolic steroids pop diuretics to dilute their urine, which decreases steroid concentration and makes it much more difficult to detect. (Of course, athletes can be tested for diuretics though, too.) Weightlifters and boxers may also down water pills to expel large amounts of fluid, which qualifies them to ...
This pivotal study compared the efficacy and tolerability of azilsartan medoxomil/chlortalidone (20/12.5-40/25 mg/day) versus azilsartan medoxomil/chlortalidone
Chlorthalidone lowers the risk of new-onset hospitalised heart failure with preserved ejection fraction (HFPEF) and heart failure with reduced left ventricular ejection fraction (HFREF) compared with amlodipine and doxazosin, US researchers say.
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Long-term follow-up of participants with heart failure in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). Circulation, Vol.124, No.17 (2011): 1811-1818. Piller, L.B., Baraniuk, S., Simpson, L.M., Cushman, W.C., Massie, B.M., Einhorn, P.T., Oparil, S., Ford, C.E., Graumlich, J.F., Dart, R.A., Parish, D.C., Tamrat M. Retta, Cuyjet, A.B., Jafri, S.Z., Furberg, C.D., Saklayen, M.G., Thadani, U., Probstfield, J.L., Davis, B.R.. ...
their meta-analysis included 3 studies with major limitations: a significant decrement in low-density lipoprotein cholesterol levels over the study period in the placebo arm (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT]), old age at therapy initiation (Pravastatin in Elderly Individuals at Risk of Vascular Disease [PROSPER] Study), and incomplete information on low-density lipoprotein cholesterol levels over the follow-up period (Air Force/Texas Coronary Atherosclerosis Prevention Study [AFCAPS/TexCAPS]). All these studies showed negative results; their inclusion would have biased against finding a benefit to statin treatment ...
This pivotal study compared the efficacy and tolerability of azilsartan medoxomil/chlortalidone (20/12.5, 20/25, 40/12.5, 40/25, 80/12.5 or 80/25 mg/day) versus
This program explains heart attacks. The program includes the following sections: what are the symptoms of a heart attack, what is the anatomy of the heart, what causes heart attacks, what is the difference between angina and heart attacks, how are heart attacks treated, how do you create an emergency plan for heart attacks, what is cardiac arrest and how do you prevent heart attacks.
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Kathy Bruckmeyer [mailto:email @ redacted] wrote: , Hey people! , Why do you look at statistics??? Kathy, its what I *DO*. Maybe I can give a little perspective to the statistical aspects of health. The statement that I made yesterday about diabetics being at the same risk for a heart attack as non-diabetics who have already had one is a statistical statement. Its based on thousands of records of data. These data are known as retrospective data since they study events that have happened in the past. Risk is a statistical term and refers to a ratio - its the rate of heart attacks in diabetics who have not had a previous heart attack divided by the rate of heart attacks in non-diabetics who have had a heart attack. That ratio is near one. Further, when this value is calculated, because a rate involves many measurements, we can also calculate a confidence interval - typically a 95% interval. This means that any value that falls within the interval is not statistically different from the central ...
Page 9 Difference Between Heart Attack And Cardiac Arrest Articles: Get information on Difference Between Heart Attack And Cardiac Arrest. Read articles and learn about all the facts related to Difference Between Heart Attack And Cardiac Arrest from
Although, there are treatments to deal with heart attack, but, you will always have to take control over your medical condition. It means that you will have to deal with your heart attack on a daily basis. The first and foremost thing is about knowing the chances that you will have a heart attack again in future. In this regard, a coronary risk profile is to be calculated to get information. After knowing this, you must act to make things better to avoid another heart attack ...
Special Bra Warn Heart Attack Articles: Get information on Special Bra Warn Heart Attack. Read articles and learn about all the facts related to Special Bra Warn Heart Attack from our health website Onlymyhealth.com.
Learn about heart attack causes, what heart attack causes are most common, and how to help reduce potential causes of heart attack.
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Yes. A heart attack can be different in women than men. When we think of someone having a heart attack, we typically picture an older man clutching his breastbone and complaining of chest pain or pressure. But symptoms of a heart attack may be different in men than in women.
How often men have sex affects their risk for heart attack. Watch the video to learn more from Dr. Oz about how often men should have sex to reduce their risk of heart attack.
People often think that a heart attack is the same thing as a cardiac arrest. This, however, is not true. In order to understand the difference between a heart attack and a cardiac arrest, it is first necessary to understand what happens in both of these processes.
After youve had a heart attack, you may be worried that you could have another one. Thats easy to understand. But the good news is that there are things you can do to reduce your risk of having another heart attack. Taking medicine, doing cardiac rehabilitation, and making healthy lifestyle changes can help...
It is vital to know what to do if someone has a heart attack. Time is precious and should not be wasted while attending to a person who has had a heart attack.
Volunteer with Association for Eradication of Heart Attack. Find Association for Eradication of Heart Attack volunteering opportunities at VolunteerMatch!
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Often, people mistakenly think that heart attack and cardiac arrest are the same thing, but thats not the case. Heres some info on what makes them different.
Often, people mistakenly think that heart attack and cardiac arrest are the same thing, but thats not the case. Heres some info on what makes them different.
For many women, a heart attack may feel like a strange discomfort in the back or some other easily ignored sign, instead of crushing chest pain.
»A woman says she is lucky to be alive after she was forced to crawl for more than ten minutes along a road after no one stopped to help her when she had a heart attack.
For many women, a heart attack may feel like a strange discomfort in the back or some other easily ignored sign, instead of crushing chest pain.
In a major breakthrough, scientists have developed a mechanism to determine if a person has had a heart attack within an hour. This will allow physicians t
IANS: Researchers do not yet know whether the elevated levels of PCSK9 triggers heart attack or its consequences. Toronto -A protein that increases levels
A new clot-busting drug which cuts the chance of dying from a second heart attack by 20 per cent is to benefit thousands of patients, after it was approved by the NHS funding watchdog.
Roughly half of all people who have a heart attack blame an event, such as a fight with their boss or heavy exercise. Reality is more complicated.
Heart attack can result in additional complications. Find out about common problems from the information and resources on this page.
Researchers have found a new test to assess chest pain is accurate in more rapid diagnosis of a heart attack.Chest pain does not always signify a
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ALLHAT used the thiazide diuretic chlorthalidone. (ALLHAT showed that doxazosin, an alpha-adrenergic receptor blocker, had a ... indapamide chlorthalidone metolazone Potassium-sparing diuretics: amiloride triamterene spironolactone eplerenone In the United ...
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Some more recent studies have suggested that chlorthalidone might be the more effective thiazide diuretic. It is also sometimes ... Most of the research supporting the use of thiazide diuretics in hypertension was done using chlorthalidone, a different ...
ALLHAT subjects treated with chlorthalidone had a lower rate of congestive heart failure than amlodipine or lisinopril or ... Chlortalidone (INN/BAN) or chlorthalidone (USAN) is a diuretic medication used to treat hypertension (high blood pressure), ...
Participants Assigned to Doxazosin and Chlorthalidone". Curr Control Trials Cardiovasc Med. 3 (1): 10. doi:10.1186/1468-6708-3- ...
Loop diuretics (furosemide, bumetanide, torasemide) and thiazide diuretics (e.g., chlorthalidone, hydrochlorothiazide, or ...
Diuretic medications such as loop diuretics (e.g., furosemide) or thiazides (e.g., chlorthalidone) can cause or worsen urinary ...
Chlorthalidone reduces systolic and diastolic blood pressure by 12.0/4 mmHg and the reduction is not dose related when tested ... such as chlorthalidone and metolazone. These agents are more properly termed thiazide-like diuretics. Thiazide diuretics also ...
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... chlorthalidone MeSH D02.478.770.150 --- bromosuccinimide MeSH D02.478.770.333 --- ethosuximide MeSH D02.491.203.340 --- cme- ... chlorthalidone MeSH D02.886.590.700.390 --- clopamide MeSH D02.886.590.700.410 --- dichlorphenamide MeSH D02.886.590.700.420 ... chlorthalidone MeSH D02.065.884.390 --- clopamide MeSH D02.065.884.485 --- dichlorphenamide MeSH D02.065.884.500 --- ... chlorthalidone MeSH D02.522.296.100 --- acetoin MeSH D02.522.296.400 --- diacetyl MeSH D02.522.296.900 --- ...
... chlorthalidone, chlorthiazide) - may be useful for mild CHF, but typically used in severe CHF in combination with loop ...
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Acetazolamide Bumetanide Chlorthalidone Clopamide Furosemide Hydrochlorothiazide Indapamide Mefruside Metolazone Xipamide ...
... a chlorthalidone dose of only 10 mg/day was used; clinicians in the US commonly prescribe chlorthalidone at a dose of 12.5 mg ( ... half of a 25 mg tablet), as no 10 mg formulation of chlorthalidone is currently available in the US. Chlorthalidone has ... Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit, although ... which found that chlorthalidone was effective.[36] The largest study, Antihypertensive and Lipid-Lowering Treatment to Prevent ...
Participants Assigned to Doxazosin and Chlorthalidone". Curr Control Trials Cardiovasc Med. 3 (1): 10. PMC 149403 . PMID ...
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  • In particular, the ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and heart failure when compared to Lisinopril , Amlodipine , or Doxazosin [ 2 , 3 ] . (drugbank.ca)
  • The possibility of exacerbation or activation of systemic lupus erythematosus has been reported with thiazide diuretics which are structurally related to chlorthalidone. (wikidoc.org)
  • Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. (rxwiki.com)
  • Since Thalitone (chlorthalidone) works longer in the body than other thiazide diuretics, it has a higher chance of causing electrolyte changes. (iodine.com)
  • Several classes are used, with combinations reserved for severe heart failure: Loop diuretics (e.g. furosemide, bumetanide) - most commonly used class in CHF, usually for moderate CHF Thiazide diuretics (e.g. hydrochlorothiazide, chlorthalidone, chlorthiazide) - may be useful for mild CHF, but typically used in severe CHF in combination with loop diuretics, resulting in a synergistic effect. (wikipedia.org)
  • Chlorthalidone is administered by oral ingestion and the dosage prescribed by a physician will vary. (brighthub.com)
  • In 7 women taking 50 mg of oral chlorthalidone daily prior to and after delivery, milk levels 3 days after delivery (collection times unspecified) ranged from 90 to 860 mcg/L. The authors estimated that the infant would receive about 180 mcg daily of chlorthalidone from milk at this maternal dosage. (nih.gov)
  • They are expected to use an advanced chlorthalidone dosage. (harcourthealth.com)
  • Thalitone® (chlorthalidone USP) should be used with caution in severe renal disease. (wikidoc.org)
  • Thalitone (chlorthalidone) is a well-tolerated water pill that's increasingly used to treat high blood pressure. (iodine.com)
  • Thalitone (chlorthalidone) can lead to more gouty attacks in people with gout. (iodine.com)
  • Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. (emedtv.com)
  • Although generic chlorthalidone is available, the current versions are not equivalent to brand-name Thalitone. (emedtv.com)
  • Thalitone is formulated differently and is more potent than generic chlorthalidone. (emedtv.com)
  • Once generic versions become available, it will be important to understand that the versions of generic chlorthalidone currently available will not be equivalent to generic Thalitone. (emedtv.com)
  • If the passage of urine continues to increase over time during treatment of severe progressive kidney disease, chlorthalidone should be stopped. (medbroadcast.com)
  • Side effects Buy Atenolol/Chlorthalidone loss unusual or severe or do not stop taking. (builtfree.org)
  • Do not begin using Tenoric (Atenolol/Chlorthalidone) if the patient is a child or if you have peripheral arterial disorders, uncontrolled heart failure, cardiogenic shock, 2nd or 3rd degree heart block, metabolic acidosis, an untreated tumor affecting the adrenal gland, or severe hypotension. (4nrx.md)
  • A: Combipres means using a different name for the Clonidine, Chlorthalidone. (md4u.net)
  • The content of the drug (Clonidine, Chlorthalidone) are absolutely the same in our generic Combipres and the brand name Combipres. (md4u.net)
  • Manufacturer do not spend something on Combipres advertising, there are no taxes to be paid as the product come into the country unregistered, the generic Clonidine, Chlorthalidone manufacturer is located in an offshore zone and the Clonidine, Chlorthalidone costs are way lower. (md4u.net)
  • Q: Why does the Clonidine, Chlorthalidone printed on the pill differ from the brand name Combipres one? (md4u.net)
  • Chlorthalidone is indicated in pregnancy when edema is due to pathologic causes, just as it is in the absence of pregnancy (however, see PRECAUTIONS, below). (nih.gov)
  • Understanding precautions and warnings with chlorthalidone can help ensure a safe treatment process. (emedtv.com)
  • Chlorthalidone, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. (medlineplus.gov)
  • Do not stop taking chlorthalidone without talking to your doctor. (medlineplus.gov)
  • This is the first study comparing the efficacy of a CCB plus chlorthalidone versus a CCB plus an ARB in patients who are not responding to CCB single therapy. (biomedcentral.com)
  • Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. (emedtv.com)
  • Chlorthalidone has also been found useful in edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. (nih.gov)
  • In patients with renal disease, chlorthalidone or related drugs may precipitate azotemia. (wikidoc.org)
  • Chlorthalidone may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood. (medlineplus.gov)
  • There is limited information regarding Off-Label Guideline-Supported Use of Chlorthalidone in adult patients. (wikidoc.org)
  • There is limited information regarding Off-Label Non-Guideline-Supported Use of Chlorthalidone in pediatric patients. (wikidoc.org)
  • Chlorthalidone should be used with caution in patients with impaired hepatic function or progressive liver disease, because minor alterations of fluid and electrolyte balance may precipitate hepatic coma. (wikidoc.org)
  • Hypokalemia and other electrolyte abnormalities, including hyponatremia and hypochloremic alkalosis , are common in patients receiving chlorthalidone. (wikidoc.org)
  • Of the 15,268 patients who received chlorthalidone, 501 were lost to follow-up, 851 died (633 non-CHD deaths and 218 CHD deaths) and the remaining patients are still being followed as part of the ongoing ALLHAT. (simstat.com)
  • The study result will help clinicians to choose between chlorthalidone and telmisartan in CCB-unresponsive patients. (biomedcentral.com)