Purity determination of gynalgin bactericidal tablets with HPLC method. (1/1)
The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6 mm Symmetry C8 column in a gradient elution system: mobile phase A--acetonitrile/buffer, pH 5.5 in 10:90, v/v proportion, and mobile phase B--acetonitrile/buffer, pH 5.5 in 75:25 v/v proportion. Two wavelengths: 250 nm and 315 nm were used for detection. Validation confirmed that the method was linear in a required concentration range. The values of correlation coefficients for specific drug substances and the related impurities were as high as 0.999. The results of the purity tests proved that the method was sufficiently selective and precise. (+info)Chlorquinaldol is an antimicrobial agent that belongs to the class of drugs known as quinoline derivatives. It is used primarily for its antiprotozoal and antibacterial properties. Chlorquinaldol is effective against a variety of microorganisms, including some strains of bacteria that are resistant to other antibiotics.
The drug works by inhibiting the growth of microorganisms, interfering with their ability to synthesize proteins and DNA. This helps to stop the spread of infection and promotes healing. Chlorquinaldol is available in various forms, such as tablets, suppositories, and topical creams or solutions, and is used to treat a variety of conditions, including intestinal amebiasis, bacterial vaginosis, and skin infections.
It's important to note that chlorquinaldol has been largely replaced by other more effective and safer antimicrobial agents for many of its former uses. Additionally, the use of this drug should be under the supervision of a healthcare professional, as it can have side effects and may interact with other medications.