Anti-Infective Agents, Local
Encyclopedias as Topic
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
A group of islands in the southwest Pacific. Its capital is Wellington. It was discovered by the Dutch explorer Abel Tasman in 1642 and circumnavigated by Cook in 1769. Colonized in 1840 by the New Zealand Company, it became a British crown colony in 1840 until 1907 when colonial status was terminated. New Zealand is a partly anglicized form of the original Dutch name Nieuw Zeeland, new sea land, possibly with reference to the Dutch province of Zeeland. (From Webster's New Geographical Dictionary, 1988, p842 & Room, Brewer's Dictionary of Names, 1992, p378)
Microbial Sensitivity Tests
Purity determination of gynalgin bactericidal tablets with HPLC method. (1/1)The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6 mm Symmetry C8 column in a gradient elution system: mobile phase A--acetonitrile/buffer, pH 5.5 in 10:90, v/v proportion, and mobile phase B--acetonitrile/buffer, pH 5.5 in 75:25 v/v proportion. Two wavelengths: 250 nm and 315 nm were used for detection. Validation confirmed that the method was linear in a required concentration range. The values of correlation coefficients for specific drug substances and the related impurities were as high as 0.999. The results of the purity tests proved that the method was sufficiently selective and precise. (+info)
ATC code R02 - Wikipedia
ATC code R02 Throat preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup R02 is part of the anatomical group R Respiratory system. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QR02. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. R02AA01 Ambazone R02AA02 Dequalinium R02AA03 Dichlorobenzyl alcohol R02AA05 Chlorhexidine R02AA06 Cetylpyridinium R02AA09 Benzethonium R02AA10 Myristyl-benzalkonium R02AA11 Chlorquinaldol R02AA12 Hexylresorcinol R02AA13 Acriflavinium chloride R02AA14 Oxyquinoline R02AA15 Povidone-iodine R02AA16 Benzalkonium R02AA17 Cetrimonium R02AA18 Hexamidine R02AA19 Phenol R02AA20 Various R02AA21 Octenidine R02AB01 Neomycin R02AB02 Tyrothricin R02AB03 ...
Chlorquinaldol - Wikipedia
Frontiers | In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue...
MIC of chlorquinaldol, gentamicin or fusidic acid. Staphylococci resulted the most sensitive Gram-positives to chlorquinaldol, ... MIC of chlorquinaldol, gentamicin or fusidic acid. Staphylococci resulted the most sensitive Gram-positives to chlorquinaldol, ... The activity of chlorquinaldol was investigated against a collection of bacterial isolates responsible for skin infections, ... The activity of chlorquinaldol was investigated against a collection of bacterial isolates responsible for skin infections, ...
Properties: Yellow needles from alc, mp 114-115° (slight decompn). Medicinal odor. uv max (ethanol): 316 nm (A1%1cm 170); min 280 nm. Practically insol in water. Soly (25°) in ethanol 1.0 g/100 ml of soln; chloroform 5.0 g; acetone 4.0 g; ether 3.0 g; 0.1N NaOH 1.4 g. Also sol in benzene, glacial acetic acid. ...
Chlorchinaldin H - Drugs.com
Prevention and treatment of atrophic rhinitis in pigs with Getroxel, chlorquinaldol and oxytetracycline.<...
... chlorquinaldol and oxytetracycline.. Together they form a unique fingerprint. * Chlorquinaldol Medicine & Life Sciences ... Varga J, Magyar K, Fodor L, Romváry A. Prevention and treatment of atrophic rhinitis in pigs with Getroxel, chlorquinaldol and ... Getroxel, chlorquinaldol and oxytetracycline and the former two ones combined with trimethoprim inhibited the growth of both ... Getroxel, chlorquinaldol and oxytetracycline and the former two ones combined with trimethoprim inhibited the growth of both ...
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METHODS AND COMPOSITIONS FOR TREATING CANCER - GLOBAVIR BIOSCIENCES, INC.
In some embodiments, the antimicrobial agent comprises chlorquinaldol, or a salt or solvate thereof. In some embodiments, a PD- ... In some embodiments, the antimicrobial agent comprises chlorquinaldol, or a salt or solvate thereof. In some embodiments, the ... In some embodiments, the antimicrobial agent comprises chlorquinaldol, or a salt or solvate thereof. In some embodiments, an ... In some embodiments, the antimicrobial agent comprises chlorquinaldol, or a salt or solvate thereof. In some embodiments, a ...