Chlorpropamide
Flushing
Demeclocycline
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Chlorothiazide
Diabetes Insipidus
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Erythema
X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. (1/73)
Type 1 pili-adhesive fibers expressed in most members of the Enterobacteriaceae family-mediate binding to mannose receptors on host cells through the FimH adhesin. Pilus biogenesis proceeds by way of the chaperone/usher pathway. The x-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli at 2.5 angstrom resolution reveals the basis for carbohydrate recognition and for pilus assembly. The carboxyl-terminal pilin domain of FimH has an immunoglobulin-like fold, except that the seventh strand is missing, leaving part of the hydrophobic core exposed. A donor strand complementation mechanism in which the chaperone donates a strand to complete the pilin domain explains the basis for both chaperone function and pilus biogenesis. (+info)A systematic review of drug induced ocular reactions in diabetes. (2/73)
AIMS: To conduct a systematic review of drug induced adverse ocular effects in diabetes to determine if this approach identified any previously unrecognised adverse drug effects; to make a preliminary assessment of the feasibility of this approach in identifying adverse drug reactions; and to assess the current accessibility of this information to prescribing physicians. METHODS: Literature search of online biomedical databases. The search strategy linked eye disorders with adverse drug reactions and diabetes. Source journals were classified as medical, pharmaceutical, diabetes related, or ophthalmological. It was determined whether the reactions identified were recorded in drug datasheets and the British National Formulary. RESULTS: 63 references fulfilled the selection criteria, of which 45 were considered to be relevant to the study. The majority of these were case reports but cross sectional surveys, case-control and cohort studies, and review articles were also identified. 61% of the reactions were not recorded in the British National Formulary and 41% were not recorded in the datasheets. 55% appeared in specialist ophthalmology journals. CONCLUSIONS: This is a feasible approach to the identification of adverse drug reactions. Adverse reactions not listed in the most commonly used reference sources were found. The majority were published in specialist ophthalmology journals which might not be seen by prescribing physicians. (+info)Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling. (3/73)
The mechanism by which chlorpropamide (CP) treatment promotes antidiuresis is unknown. CP competitively inhibited antidiuretic hormone (ADH) binding and adenylyl cyclase (AC) stimulation (inhibition constants K(i) and K'(i) of 2.8 mM and 250 microM, respectively) in the LLC-PK(1) cell line. CP (333 microM) increased the apparent K(a) of ADH for AC activation (0.31 vs. 0.08 nM) without affecting a maximal response, suggesting competitive antagonism. Because CP lowers "basal" AC activity and the AC activation-ADH receptor occupancy relationship (A-O plots), it is an ADH inverse agonist. Twenty-four-hour CP exposure (100 microM) upregulated the ADH receptors without affecting affinity. This lowered K(a) and increased basal AC activity and maximal response (1. 86 vs. 1.35 and 14.9 vs. 10.6 fmol cAMP. min(-1). 10(3) cells(-1), n = 6, P<0.05). NaCl, which potentiates ADH stimulation, also increased basal AC activity. This, together with the CP-ADH inverse agonism and increased basal AC activity at higher receptor density, unmasks constitutive receptor signaling. The CP-ADH inverse agonism explains receptor upregulation and predicts the need for residual ADH with functional isoreceptors for CP-mediated antidiuresis. This could be why CP ameliorates partial central diabetes insipidus but not nephrogenic diabetes insipidus. (+info)Inhibition of CFU-E/BFU-E by 3'-azido-3'-deoxythymidine, chlorpropamide, and protoporphirin IX zinc (II): a comparison between direct exposure of progenitor cells and long-term exposure of bone marrow cultures. (4/73)
Erythropoiesis occurs in two stages: proliferation amplifies cell number, and differentiation stimulates the acquisition of the functional properties of red blood cells. The erythroid colony-forming unit (CFU-E) amplifies the differentiation process in response to erythropoietic stress in vitro, whereas the burst-forming unit (BFU-E), which is not particularly sensitive to erythropoietin stimulation, gives rise to the CFU-E and, when stimulated, produces morphologically-identifiable erythroid colonies. The aim of this work was to evaluate the toxic effects of the antiviral agent, 3'-azido-3'-deoxythymidine (AZT), the antidiabetic drug, chlorpropamide (CLP), and the heme-analogous compound, protophorphirin IX zinc (II) (ZnPP), on the proliferation of erythroblastic progenitors by using human umbilical-cord blood cells and murine progenitors from long-term bone marrow cultures. All these agents may interfere with the hemopoietic process, causing myelotoxicity as an adverse effect via different mechanisms. Our results showed selective toxicity of the three drugs on the erythroid progenitors (IC(50): AZT 0.35 +/- 0.13 microM, ZnPP 23.34 +/- 1.16 microM, CLP 1.07 +/- 0.27 mM), with respect to the myeloid progenitors (IC(50): AZT 0.8 microM, ZnPP 103.9 +/- 3.9 microM and CLP > 2800 microM). The IC(50) values were well correlated with peak plasma levels reached in vivo by the drugs. There was a marked similarity between the drug sensitivities of the human and murine progenitors but differences in toxicity exerted by the drugs on the basis of the time of exposure. Drug treatment of long-term cultures, followed by the clonogenic assay of progenitors collected from them in the absence of the drugs, generally resulted in a lower hematotoxicity. (+info)Investigation of hypoglycemic properties of rectal suppositories with chlorpropamide. (5/73)
Rectal suppositories with chlorpropamide and suppositories with chlorpropamide in the dispersion system with urea were prepared. Witepsol H15 and H19 and a polyoxyethyleneglycol mixture were used as bases. Rabbits were tested for blood-glucose level. The animals have been administered with prepared suppositories and commercial tablets. It was found that the suppositories prepared on the basis Witepsol H 15 with the dispersed chlorpropamide caused a much higher decrease of blood-glucose level than commercial tablets. (+info)Crystal doping aided by rapid expansion of supercritical solutions. (6/73)
The purpose of this study was to test the utility of rapid expansion of supercritical solution (RESS) based cocrystallizations in inducing polymorph conversion and crystal disruption of chlorpropamide (CPD). CPD crystals were recrystallized by the RESS process utilizing supercritical carbon dioxide as the solvent. The supercritical region investigated for solute extraction ranged from 45 to 100 degrees C and 2000 to 8000 psi. While pure solute recrystallization formed stage I of these studies, stage II involved recrystallization of CPD in the presence of urea (model impurity). The composition, morphology, and crystallinity of the particles thus produced were characterized utilizing techniques such as microscopy, thermal analysis, x-ray powder diffractometry, and high-performance liquid chromatography. Also, comparative evaluation between RESS and evaporative crystallization from liquid solvents was performed. RESS recrystallizations of commercially available CPD (form A) resulted in polymorph conversion to metastable forms C and V, depending on the temperature and pressure of the recrystallizing solvent. Cocrystallization studies revealed the formation of eutectic mixtures and solid solutions of CPD + urea. Formation of the solid solutions resulted in the crystal disruption of CPD and subsequent amorphous conversion at urea levels higher than 40% wt/wt. Consistent with these results were the reductions in melting point (up to 9 degrees C) and in the DeltaH(f) values of CPD (up to 50%). Scanning electron microscopy revealed a particle size reduction of up to an order of magnitude upon RESS processing. Unlike RESS, recrystallizations from liquid organic solvents lacked the ability to affect polymorphic conversions. Also, the incorporation of urea into the lattice of CPD was found to be inadequate. In providing the ability to control both the particle and crystal morphologies of active pharmaceutical ingredients, RESS proved potentially advantageous to crystal engineering. Rapid crystallization kinetics were found vital in making RESS-based doping superior to conventional solvent-based cocrystallizations. (+info)Effect of sulfonylureas on triglyceride metabolism in the rat liver: possible role of the lysosomes in hepatic lipolysis. (7/73)
It has been suggested previously that chlorpropamide and other hypoglycemic sulfonylureas interfere with hepatic triglyceride breakdown. Since ketogenesis from endogenous hepatic lipid stores is a measure of hepatic triglyceride hydrolysis, ketogenesis derived from endogenous lipids as well as ketogenesis derived from exogenously added isotopic oleate was determined in isolated hepatocytes from fasted rats in an attempt to identify the nature of the direct effects of sulfonylureas on hepatic lipid metabolism. Ketogenesis from endogenous lipids was inhibited by 1 mM chlorpropamide, while ketone production from exogenous oleate did not change. The effect of chlorpropamide on hepatic triglyceride metabolism was further studied in the isolated perfused liver of normal rats in the presence of a continuous [3H]oleate infusion and in isolated liver cells incubated in the presence of [3H]oleate. In liver perfusion experiments, 1 mM chlorpropamide enhanced the incorporation of tritium into triglycerides (but not other lipid classes) and increased both liver triglyceride content and triglyceride secretion. Using isolated cells similar effects could be demonstrated at 0.5 mM chlorpropamide. Chlorpropamide, tolbutamide, and carbutamide, all of which inhibited endogenous ketogenesis in isolated liver cells, also inhibited lysosomal triglyceride lipase activity in rat liver homogenates. The drugs were not inhibitory towards alkaline lipase activity. Demethylglycodiazin (2-benzolsulfonamid--5-(beta-hydroxyethoxy)-pyrimidin), which did not inhibit endogenous ketogenesis in isolated liver cells, did not affect lysosomal lipase activity. The lysosomotropic drug chloroquine was markedly antiketogenic when tested in liver cells. The reduction in endogenous ketogenesis, the enhanced accumulation of liver triglycerides, and the stimulation of hepatic triglyceride output by chlorpropamide are ascribed to an interference of the drug with hepatic triglyceride breakdown. The present results also suggest that the lysosomes play a significant role in hepatic lipolysis. (+info)A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine. (8/73)
A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis. (+info)Chromatographic studies of chlorpropamide interactions with normal and glycated human serum albumin based on affinity...
Chlorpropamide - DrugBank
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Chlorpropamide inhibition of excision repair and postreplication repair of ultraviolet damage in Chinese hamster ovary cells
Chlorpropamide (discontinued in the UK)
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes<...
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Chlorpropamide-alcohol flushing, malar thermal circulation ind...
United Kingdom prospective diabetes study (UKPDS) 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or...
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Patient Reviews
Chlorpropamide
... is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation ... Chlorpropamide, while effective in the treatment of diabetics in patients of Chinese descent, should never be used in people of ... Like other sulfonylureas, chlorpropamide acts to increase the secretion of insulin, so it is only effective in patients who ... Chlorpropamide and other sulfonylureas encourage weight gain, so they are generally not favored for use in very obese patients ...
Tolbutamide
Chlorpropamide Walker SR (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109 ...
Antidiuretic
Miscellaneous others include chlorpropamide and carbamazepine. Diuretic Electrolyte Water-electrolyte imbalance Antidiuretic+ ...
Sulfonylurea
First-generation drugs include acetohexamide, carbutamide, chlorpropamide, glycyclamide (tolcyclamide), metahexamide, ... Chlorpropamide (1st generation) Tolazamide (1st generation) Gliclazide (2nd generation) Glimepiride (2nd generation) ...
Glossary of diabetes
Chlorpropamide a pill taken to lower the level of glucose (sugar) in the blood. Only people with Type 2 diabetes take these ...
Rachel Kiddell-Monroe
Mazovetskiĭ, A G; Danilova, N S (1972-03-01). "[Antidiuretic action of chlorpropamide (Diabinese) in a case of combined ...
Drug interaction
... and may cause hypoglycemia when taken with chlorpropamide. Ginkgo biloba can cause bleeding when combined with warfarin or ...
Helium compounds
For example with chlorpropamide over 0.3 GPa in helium changes to a monoclinic structure, and yet another structural form at ... different behaviour of β-chlorpropamide in different inert gas and liquid media". RSC Advances. 6 (95): 92629-92637. doi: ...
Aldehyde dehydrogenase 3 family, member A1
... by chlorpropamide analogues". Biochem. Pharmacol. 55 (4): 465-74. doi:10.1016/S0006-2952(97)00475-9. PMID 9514081. Simpson JC, ...
List of drugs: Cf-Ch
... chlorpropamide (INN) chlorprothixene (INN) chlorquinaldol (INN) Chlortab chlortalidone (INN) chlortetracycline (INN) ...
Appetite stimulant
... chlorpropamide and tolbutamide Mood stabilizers such as lithium Some anti-epileptic drugs such as valproate, carbamazepine and ...
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chlorproPAMIDE clomiPHENE vs. clomiPRAMINE cycloSERINE vs. cycloSPORINE DAUNOrubicin vs. DOXOrubicin DOBUTamine vs. DOPamine ...
Aspirin
... including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid ( ...
List of MeSH codes (D02)
... chlorpropamide MeSH D02.886.590.795.475 - gliclazide MeSH D02.886.590.795.500 - glipizide MeSH D02.886.590.795.575 - glyburide ... chlorpropamide MeSH D02.948.828.475 - gliclazide MeSH D02.948.828.575 - glyburide MeSH D02.948.828.834 - tolazamide MeSH ...
Disulfiram-like drug
Phenacetin Phentolamine Phenylbutazone Procarbazine Propranolol Sulfiram Sulfonamides Sulfonylureas such as chlorpropamide, ...
List of drugs: Df-Di
... redirects to Chlorpropamide diacerein (INN) diacetamate (INN) diacetolol (INN) diacetylmorphine known also as diamorphine and ...
Syndrome of inappropriate antidiuretic hormone secretion
Pulmonary causes Infection Pneumonia Lung abscess Asthma Cystic fibrosis Drugs Chlorpropamide Clofibrate Phenothiazine ...
Allopurinol
Vidarabine Chlorpropamide Phenytoin Theophylline Cyclophosphamide, doxorubicin, bleomycin, procarbazine, mechlorethamine Co- ...
Disulfiram
... tolbutamide and chlorpropamide Several cephalosporin drugs, including cefoperazone, cefamandole and cefotetan, that have a N- ...
ATC code A10
A10BA01 Phenformin A10BA02 Metformin A10BA03 Buformin A10BB01 Glibenclamide A10BB02 Chlorpropamide A10BB03 Tolbutamide A10BB04 ...
List of causes of hypoglycemia
... palmitoyltransferase I deficiency Carnitine-acylcarnitine translocase deficiency Chloramphenicol Chlorpromazine Chlorpropamide ...
List of sulfonamides
Sulfametoxydiazine Ultra long-acting Sulfadoxine Sulfametopyrazine Terephtyl Acetohexamide Carbutamide Chlorpropamide ...
Elevated alkaline phosphatase
... chlorpropamide, numerous antibiotics Bone disease (bone ALP): Paget's disease, osteosarcoma, bone metastases of prostatic ...
Diabetes medication
First-generation agents tolbutamide acetohexamide tolazamide chlorpropamide Second-generation agents glipizide glyburide or ...
Chlorpropamide: MedlinePlus Drug Information
Chlorpropamide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Chlorpropamide helps control blood sugar but does not cure diabetes. Continue to take chlorpropamide even if you feel well. Do ... Before taking chlorpropamide,. *tell your doctor and pharmacist if you are allergic to chlorpropamide, any other medications, ... After you have taken chlorpropamide for some time, chlorpropamide may not control your blood sugar as well as it did at the ...
Chlorpropamide: Indication, Dosage, Side Effect, Precaution | MIMS Philippines
Chlorpropamide: Search drug information, interaction, images & medical diagnosis. The most comprehensive database of medicines ... Chlorpropamide, CID=2727, https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpropamide (accessed on Jan. 21, 2020). ... Chlorpropamide. Source: National Center for Biotechnology Information. PubChem Database. ... Description: Chlorpropamide stimulates the secretion of endogenous insulin from β-cells of the pancreas. It also exhibits ...
LOINC 73453-3 - chlorproPAMIDE induced platelet IgG Ab [Presence] in Serum or Plasma by Flow cytometry (FC)
LOINC Code 73453-3 chlorproPAMIDE induced platelet IgG Ab [Presence] in Serum or Plasma by Flow cytometry (FC) ... chlorproPAMIDE induced platelet IgG FC Ql. Consumer Name Alpha. chlorproPAMIDE induced platelet IgG, Blood. Example Answer List ... Chlorpropamide is a first-generation sulfonylurea drug. Source: Regenstrief Institute. LP16075-1 chlorproPAMIDE. Sulfonylurea ( ... LP16075-1 chlorproPAMIDE. Chlorpropamide testing is intended for use during the evaluation of suspected insulinoma ...
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Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
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"Plasma chlorpropamide: a critical factor in chlorpropamide-alcohol flush." Eur J Clin Pharmacol 24 (1983): 237-42 ... "Plasma chlorpropamide: a critical factor in chlorpropamide-alcohol flush." Eur J Clin Pharmacol 24 (1983): 237-42 ... "Metabolic studies in chlorpropamide-alcohol flush positive and negative type 2 (non-insulin dependent) diabetic patients with ... "Metabolic studies in chlorpropamide-alcohol flush positive and negative type 2 (non-insulin dependent) diabetic patients with ...
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DiabineseGlipizideTolbutamideSulfonylureasPancreatic beta cellsSulfonylureaDiabetesSecretionHypoglycemiaPancreasTabletIngestionPlasmaOralPatientsReferencesIncreaseIncludeBloodTimeGlyburideAcetohexamideTolbutamide and ChlorpropamideTolazamideChlorproMAZINESulfonylureaPhenytoinCarcinogenicityTaken chlorpropamideInsulinThiazide diureticsTacrolimusPhenylbutazoneDrugsToxicitySyndrome of inapHepaticLowersDiscontinueInhibitorsReactionEvaluationReactionsReductionDoseInteractionDrug
Diabinese2
- Diabinese (chlorpropamide). (drugs.com)
- Diabinese (chlorpropamide) is an oral blood-glucose-lowering drug of the sulfonylurea class(Inzucchiet al. (researchwap.net)
Glipizide1
- These agents include chlorpropamide and tolbutamide (first-generation), as well as glipizide, glyburide, and glimepiride (second-generation), are secretagogues (ie, medications that stimulate insulin secretion). (medscape.com)
Tolbutamide1
- Oral diabetes medications-tolbutamide and chlorpropamide-can cause dizziness, flushing, and nausea when combined with alcohol. (diabeticgourmet.com)
Sulfonylureas2
- Chlorpropamide is in a class of medications called sulfonylureas. (medlineplus.gov)
- A disulfiram-like reaction (e.g., flushing, headache, and nausea) to alcohol has been reported frequently with the use of chlorpropamide and very rarely with other sulfonylureas. (drugs.com)
Pancreatic beta cells2
- Chlorpropamide may increase insulin secretion from pancreatic beta cells. (medscape.com)
- Chlorpropamide is a first-generation sulfonylurea that stimulates the release of insulin from pancreatic beta cells. (medscape.com)
Sulfonylurea1
- Chlorpropamide is a first-generation sulfonylurea drug. (loinc.org)
Diabetes5
- Chlorpropamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). (medlineplus.gov)
- Chlorpropamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). (medlineplus.gov)
- Chlorpropamide helps control blood sugar but does not cure diabetes. (medlineplus.gov)
- Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes. (drugs.com)
- Is Chlorpropamide (intevention) more efficient than Metformin (comparator) in managing Diabetes Mellitus Type 2 (problem) for obese elderly patients (population)? (ucla.edu)
Secretion1
- Chlorpropamide stimulates the secretion of endogenous insulin from β-cells of the pancreas. (mims.com)
Hypoglycemia2
- Chlorpropamide testing is intended for use during the evaluation of suspected insulinoma characterized by hypoglycemia and increased plasma insulin concentration. (loinc.org)
- Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. (bvsalud.org)
Pancreas1
- Chlorpropamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. (medlineplus.gov)
Tablet2
- Chlorpropamide comes as a tablet to take by mouth. (medlineplus.gov)
- Chlorpropamide Tablet (Mylan Pharmaceuticals Inc.). DailyMed. (mims.com)
Ingestion2
- CASE REPORT: In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. (bvsalud.org)
- We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. (bvsalud.org)
Plasma1
- Plasma chlorpropamide: a critical factor in chlorpropamide-alcohol flush. (drugs.com)
Oral1
- Protein-bound drugs (e.g. oral anticoagulants, hydantoins, salicylates, other NSAIDs, sulfonamides) may potentiate hypoglycaemic action of chlorpropamide. (mims.com)
Patients3
- Metabolic studies in chlorpropamide-alcohol flush positive and negative type 2 (non-insulin dependent) diabetic patients with and without retinopathy. (drugs.com)
- Thus, a viagra en ligne arnaque patient with an endotracheal tube in most patients. (aaan.org)
- The hypoglycemic agent chlorpropamide helps to relieve diuresis in patients with DI. (medscape.com)
References1
- Disclaimer: This information is independently developed by MIMS based on Chlorpropamide from various references and is provided for your reference only. (mims.com)
Increase1
- Your doctor will probably start you on a low dose of chlorpropamide and gradually increase your dose if needed. (medlineplus.gov)
Include1
- Less severe hypoxemia pao mm hg higher than in chronic respiratory acidosis, a. arnaque ligne viagra en Acute dialysis indications include patient comfort. (aaan.org)
Blood1
- After you have taken chlorpropamide for some time, chlorpropamide may not control your blood sugar as well as it did at the beginning of your treatment. (medlineplus.gov)
Time1
- To help you remember to take chlorpropamide, take it around the same time(s) every day. (medlineplus.gov)
Glyburide1
- When transferring obat provera 10 mg patients from oral hypoglycemic agents other than chlorpropamide to glyburide tablets, no transition period and no initial or priming dose are necessary. (ndstrytowns.ca)
Acetohexamide1
- Acetohexamide is an oral hypoglycemic agent of the arylsulfonyl-urea group with a potency between that of tolbutamide and chlorpropamide. (nih.gov)
Tolbutamide and Chlorpropamide2
- 11. Khalid S, Khawla S. Gas Chromatographic Method for Determination of Tolbutamide and Chlorpropamide. (rjptonline.org)
- Several inhibitors of PEPT1 have been identified: sulfonylurea antidiabetic drugs such as nateglinide, glibenclamide, tolbutamide and chlorpropamide, sartans, and the ester prodrugs of ACE inhibitors [15-17]. (solvobiotech.com)
Tolazamide1
- Clinical experience in diabetic patients has demonstrated tolazamide to be approximately 5 times more potent than tolbutamide on a milligram basis, and approximately equivalent in milligram potency to chlorpropamide. (nih.gov)
ChlorproMAZINE1
- ChlorproMAZINE and ChlorproPAMIDE). (nih.gov)
Sulfonylurea1
- Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (rxreasoner.com)
Phenytoin1
- Hypoglycemic agents (chlorpropamide and tolbutamide) and anticonvulsants (phenytoin and phenobarbital) may accumulate in the body as a result of interference with either their metabolism or excretion. (medlibrary.org)
Carcinogenicity1
- Bioassay of chlorpropamide for possible carcinogenicity. (maisonneuve-group.com)
Taken chlorpropamide1
- After you have taken chlorpropamide for some time, chlorpropamide may not control your blood sugar as well as it did at the beginning of your treatment. (medlineplus.gov)
Insulin4
- Chlorpropamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). (medlineplus.gov)
- Chlorpropamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. (medlineplus.gov)
- Chlorpropamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). (medlineplus.gov)
- Chlorpropamide may increase insulin secretion from pancreatic beta cells. (medscape.com)
Thiazide diuretics1
- Other useful medications include chlorpropamide and thiazide diuretics, which can result in a 25-75% reduction in urine volume and can be used in combination with each other. (medscape.com)
Tacrolimus1
- Chlorpropamide: moderate tacrolimus with obstruction, age. (farmfreshdeliver.com)
Phenylbutazone1
- Liver damage due to phenylbutazone and chlorpropamide]. (nih.gov)
Drugs1
- Older generations of these drugs include chlorpropamide and tolbutamide, now hardly in use. (diabetesdhrc.com)
Toxicity4
- Association of hyperinsulinemia with chlorpropamide toxicity. (nih.gov)
- chlorpropamide increases toxicity of dronabinol by aldehyde dehydrogenase inhibition. (medscape.com)
- chlorpropamide increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. (medscape.com)
- Genetic Toxicity Evaluation of Chlorpropamide in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Syndrome of inap2
- Chlorpropamide induced syndrome of inappropriate antidiuretic hormone secretion. (jpgmonline.com)
- Endocrine Reactions: On rare occasions, chlorpropamide has caused a reaction identical to the syndrome of inappropriate antidiuretic hormone (ADH) secretion. (brainandnervecenter.com)
Hepatic2
- ivosidenib will decrease the level or effect of chlorpropamide by affecting hepatic enzyme CYP2C9/10 metabolism. (medscape.com)
- lumacaftor/ivacaftor will decrease the level or effect of chlorpropamide by affecting hepatic enzyme CYP2C9/10 metabolism. (medscape.com)
Lowers1
- The mechanism by which chlorpropamide lowers blood glucose during long-term administration has not been clearly established. (rxreasoner.com)
Discontinue2
- Discontinue chlorpropamide at least 14 days before starting dronabinol solution and do not administer chlorpropamide within 7 days of completing treatment with dronabinol solution. (medscape.com)
- If you are already taking other antidiabetes medications such as chlorpropamide, follow the doctor's advice carefully on whether to discontinue or continue the old drug before starting metformin. (thisisaaronslife.com)
Inhibitors1
- The most potent inhibitors of sepiapterin reduction (IC50s = 31-180 nM) were sulfasalazine, sulfathiazole, sulfapyridine, sulfamethoxazole, and chlorpropamide. (nih.gov)
Reaction2
- Hepatotoxic reaction associated with metformin and chlorpropamide treatment]. (nih.gov)
- 4. Kishikawa N, Hammad FS, Ohyama K, Kubo K, Mabrouk MM, Nakashima K, Kuroda N. HPLC Determination of Chlorpropamide in Human Serum by Fluorogenicderivatization Based on The Suzuki Coupling Reaction with Phenylboronic Acid. (rjptonline.org)
Evaluation1
- 12. Nasierowska Z, Suffczynski J, Szyszko E, Taton J, Kolinski P, Czech A, Wojterska J. Modification of The Gas Chromatographic Method for Blood Chlorpropamide Determination and Evaluation of Its Use for Clinical and Pharmacological Purposes. (rjptonline.org)
Reactions1
- Dronabinol oral solution (Syndros) contains 50% (w/w) dehydrated alcohol 5.5% (w/w) propylene glycol, which can produce disulfiramlike reactions if coadministered with chlorpropamide. (medscape.com)
Reduction1
- A square wave voltammetric technique coupled with three electrode detection system consist of hanging mercury drop electrode (HMDE) as working electrode, 1mm platinum wire as an auxiliary electrode (Pt-wire) and silver/silver chloride saturated potassium chloride (Ag/AgCl.sat.KCl) as reference electrode was used to determine the chlorpropamide indirectly through its interaction with valsartan, chlorpropamide gives no reduction peaks in the studied range. (rjptonline.org)
Dose1
- Your doctor will probably start you on a low dose of chlorpropamide and gradually increase your dose if needed. (medlineplus.gov)
Interaction1
- The limit of detection for chlorpropamide was 4.89 x 10-9 M through its interaction with valsartan. (rjptonline.org)
Drug1
- Gold Standard Drug Database: Drug Monograph: Chlorpropamide, 2016. (limamemorial.org)