A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.
A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.
A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Glucose in blood.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Mechanical food dispensing machines.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Substances which lower blood glucose levels.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
A technique used to separate particles according to their densities in a continuous density gradient. The sample is usually mixed with a solution of known gradient materials and subjected to centrifugation. Each particle sediments to the position at which the gradient density is equal to its own. The range of the density gradient is usually greater than that of the sample particles. It is used in purifying biological materials such as proteins, nucleic acids, organelles, and cell types.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Sweet food products combining cane or beet sugars with other carbohydrates and chocolate, milk, eggs, and various flavorings. In the United States, candy refers to both sugar- and cocoa-based confections and is differentiated from sweetened baked goods; elsewhere the terms sugar confectionary, chocolate confectionary, and flour confectionary (meaning goods such as cakes and pastries) are used.
The seeking and acceptance by patients of health service.
A plant genus of the family POACEAE. The common name of wheatgrass is also used for other plants in the family.
An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.
A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
Pathological processes of the PANCREAS.
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
Surgical removal of the pancreas. (Dorland, 28th ed)
Facilities which provide information concerning poisons and treatment of poisoning in emergencies.
A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.
Facilities for collecting and organizing information. They may be specialized by subject field, type of source material, persons served, location, or type of services.
A center in the HEALTH RESOURCES ADMINISTRATION Division of Planning Methods and Technology which provides access to current information on health planning and resources development.
Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed)

X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. (1/73)

Type 1 pili-adhesive fibers expressed in most members of the Enterobacteriaceae family-mediate binding to mannose receptors on host cells through the FimH adhesin. Pilus biogenesis proceeds by way of the chaperone/usher pathway. The x-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli at 2.5 angstrom resolution reveals the basis for carbohydrate recognition and for pilus assembly. The carboxyl-terminal pilin domain of FimH has an immunoglobulin-like fold, except that the seventh strand is missing, leaving part of the hydrophobic core exposed. A donor strand complementation mechanism in which the chaperone donates a strand to complete the pilin domain explains the basis for both chaperone function and pilus biogenesis.  (+info)

A systematic review of drug induced ocular reactions in diabetes. (2/73)

AIMS: To conduct a systematic review of drug induced adverse ocular effects in diabetes to determine if this approach identified any previously unrecognised adverse drug effects; to make a preliminary assessment of the feasibility of this approach in identifying adverse drug reactions; and to assess the current accessibility of this information to prescribing physicians. METHODS: Literature search of online biomedical databases. The search strategy linked eye disorders with adverse drug reactions and diabetes. Source journals were classified as medical, pharmaceutical, diabetes related, or ophthalmological. It was determined whether the reactions identified were recorded in drug datasheets and the British National Formulary. RESULTS: 63 references fulfilled the selection criteria, of which 45 were considered to be relevant to the study. The majority of these were case reports but cross sectional surveys, case-control and cohort studies, and review articles were also identified. 61% of the reactions were not recorded in the British National Formulary and 41% were not recorded in the datasheets. 55% appeared in specialist ophthalmology journals. CONCLUSIONS: This is a feasible approach to the identification of adverse drug reactions. Adverse reactions not listed in the most commonly used reference sources were found. The majority were published in specialist ophthalmology journals which might not be seen by prescribing physicians.  (+info)

Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling. (3/73)

The mechanism by which chlorpropamide (CP) treatment promotes antidiuresis is unknown. CP competitively inhibited antidiuretic hormone (ADH) binding and adenylyl cyclase (AC) stimulation (inhibition constants K(i) and K'(i) of 2.8 mM and 250 microM, respectively) in the LLC-PK(1) cell line. CP (333 microM) increased the apparent K(a) of ADH for AC activation (0.31 vs. 0.08 nM) without affecting a maximal response, suggesting competitive antagonism. Because CP lowers "basal" AC activity and the AC activation-ADH receptor occupancy relationship (A-O plots), it is an ADH inverse agonist. Twenty-four-hour CP exposure (100 microM) upregulated the ADH receptors without affecting affinity. This lowered K(a) and increased basal AC activity and maximal response (1. 86 vs. 1.35 and 14.9 vs. 10.6 fmol cAMP. min(-1). 10(3) cells(-1), n = 6, P<0.05). NaCl, which potentiates ADH stimulation, also increased basal AC activity. This, together with the CP-ADH inverse agonism and increased basal AC activity at higher receptor density, unmasks constitutive receptor signaling. The CP-ADH inverse agonism explains receptor upregulation and predicts the need for residual ADH with functional isoreceptors for CP-mediated antidiuresis. This could be why CP ameliorates partial central diabetes insipidus but not nephrogenic diabetes insipidus.  (+info)

Inhibition of CFU-E/BFU-E by 3'-azido-3'-deoxythymidine, chlorpropamide, and protoporphirin IX zinc (II): a comparison between direct exposure of progenitor cells and long-term exposure of bone marrow cultures. (4/73)

Erythropoiesis occurs in two stages: proliferation amplifies cell number, and differentiation stimulates the acquisition of the functional properties of red blood cells. The erythroid colony-forming unit (CFU-E) amplifies the differentiation process in response to erythropoietic stress in vitro, whereas the burst-forming unit (BFU-E), which is not particularly sensitive to erythropoietin stimulation, gives rise to the CFU-E and, when stimulated, produces morphologically-identifiable erythroid colonies. The aim of this work was to evaluate the toxic effects of the antiviral agent, 3'-azido-3'-deoxythymidine (AZT), the antidiabetic drug, chlorpropamide (CLP), and the heme-analogous compound, protophorphirin IX zinc (II) (ZnPP), on the proliferation of erythroblastic progenitors by using human umbilical-cord blood cells and murine progenitors from long-term bone marrow cultures. All these agents may interfere with the hemopoietic process, causing myelotoxicity as an adverse effect via different mechanisms. Our results showed selective toxicity of the three drugs on the erythroid progenitors (IC(50): AZT 0.35 +/- 0.13 microM, ZnPP 23.34 +/- 1.16 microM, CLP 1.07 +/- 0.27 mM), with respect to the myeloid progenitors (IC(50): AZT 0.8 microM, ZnPP 103.9 +/- 3.9 microM and CLP > 2800 microM). The IC(50) values were well correlated with peak plasma levels reached in vivo by the drugs. There was a marked similarity between the drug sensitivities of the human and murine progenitors but differences in toxicity exerted by the drugs on the basis of the time of exposure. Drug treatment of long-term cultures, followed by the clonogenic assay of progenitors collected from them in the absence of the drugs, generally resulted in a lower hematotoxicity.  (+info)

Investigation of hypoglycemic properties of rectal suppositories with chlorpropamide. (5/73)

Rectal suppositories with chlorpropamide and suppositories with chlorpropamide in the dispersion system with urea were prepared. Witepsol H15 and H19 and a polyoxyethyleneglycol mixture were used as bases. Rabbits were tested for blood-glucose level. The animals have been administered with prepared suppositories and commercial tablets. It was found that the suppositories prepared on the basis Witepsol H 15 with the dispersed chlorpropamide caused a much higher decrease of blood-glucose level than commercial tablets.  (+info)

Crystal doping aided by rapid expansion of supercritical solutions. (6/73)

The purpose of this study was to test the utility of rapid expansion of supercritical solution (RESS) based cocrystallizations in inducing polymorph conversion and crystal disruption of chlorpropamide (CPD). CPD crystals were recrystallized by the RESS process utilizing supercritical carbon dioxide as the solvent. The supercritical region investigated for solute extraction ranged from 45 to 100 degrees C and 2000 to 8000 psi. While pure solute recrystallization formed stage I of these studies, stage II involved recrystallization of CPD in the presence of urea (model impurity). The composition, morphology, and crystallinity of the particles thus produced were characterized utilizing techniques such as microscopy, thermal analysis, x-ray powder diffractometry, and high-performance liquid chromatography. Also, comparative evaluation between RESS and evaporative crystallization from liquid solvents was performed. RESS recrystallizations of commercially available CPD (form A) resulted in polymorph conversion to metastable forms C and V, depending on the temperature and pressure of the recrystallizing solvent. Cocrystallization studies revealed the formation of eutectic mixtures and solid solutions of CPD + urea. Formation of the solid solutions resulted in the crystal disruption of CPD and subsequent amorphous conversion at urea levels higher than 40% wt/wt. Consistent with these results were the reductions in melting point (up to 9 degrees C) and in the DeltaH(f) values of CPD (up to 50%). Scanning electron microscopy revealed a particle size reduction of up to an order of magnitude upon RESS processing. Unlike RESS, recrystallizations from liquid organic solvents lacked the ability to affect polymorphic conversions. Also, the incorporation of urea into the lattice of CPD was found to be inadequate. In providing the ability to control both the particle and crystal morphologies of active pharmaceutical ingredients, RESS proved potentially advantageous to crystal engineering. Rapid crystallization kinetics were found vital in making RESS-based doping superior to conventional solvent-based cocrystallizations.  (+info)

Effect of sulfonylureas on triglyceride metabolism in the rat liver: possible role of the lysosomes in hepatic lipolysis. (7/73)

It has been suggested previously that chlorpropamide and other hypoglycemic sulfonylureas interfere with hepatic triglyceride breakdown. Since ketogenesis from endogenous hepatic lipid stores is a measure of hepatic triglyceride hydrolysis, ketogenesis derived from endogenous lipids as well as ketogenesis derived from exogenously added isotopic oleate was determined in isolated hepatocytes from fasted rats in an attempt to identify the nature of the direct effects of sulfonylureas on hepatic lipid metabolism. Ketogenesis from endogenous lipids was inhibited by 1 mM chlorpropamide, while ketone production from exogenous oleate did not change. The effect of chlorpropamide on hepatic triglyceride metabolism was further studied in the isolated perfused liver of normal rats in the presence of a continuous [3H]oleate infusion and in isolated liver cells incubated in the presence of [3H]oleate. In liver perfusion experiments, 1 mM chlorpropamide enhanced the incorporation of tritium into triglycerides (but not other lipid classes) and increased both liver triglyceride content and triglyceride secretion. Using isolated cells similar effects could be demonstrated at 0.5 mM chlorpropamide. Chlorpropamide, tolbutamide, and carbutamide, all of which inhibited endogenous ketogenesis in isolated liver cells, also inhibited lysosomal triglyceride lipase activity in rat liver homogenates. The drugs were not inhibitory towards alkaline lipase activity. Demethylglycodiazin (2-benzolsulfonamid--5-(beta-hydroxyethoxy)-pyrimidin), which did not inhibit endogenous ketogenesis in isolated liver cells, did not affect lysosomal lipase activity. The lysosomotropic drug chloroquine was markedly antiketogenic when tested in liver cells. The reduction in endogenous ketogenesis, the enhanced accumulation of liver triglycerides, and the stimulation of hepatic triglyceride output by chlorpropamide are ascribed to an interference of the drug with hepatic triglyceride breakdown. The present results also suggest that the lysosomes play a significant role in hepatic lipolysis.  (+info)

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine. (8/73)

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.  (+info)

TY - JOUR. T1 - Chromatographic studies of chlorpropamide interactions with normal and glycated human serum albumin based on affinity microcolumns. AU - Tao, Pingyang. AU - Li, Zhao. AU - Matsuda, Ryan. AU - Hage, David S.. PY - 2018/10/15. Y1 - 2018/10/15. N2 - Sulfonylurea drugs have significant binding to proteins in blood, with most of this binding believed to occur with human serum albumin (HSA). High performance affinity chromatography and affinity microcolumns containing immobilized HSA were used to investigate binding by the sulfonylurea drug chlorpropamide to normal HSA and glycated HSA, which is a modified form of HSA that has an increased serum concentration in diabetes. Experiments employing frontal analysis indicated that the binding by chlorpropamide gave a good fit to a two-site model for both normal HSA and glycated HSA samples that were representative of controlled or advanced diabetes. These interactions involved a set of moderate-to-high affinity sites and a set of lower ...
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Chlorpropamide is not recommended for the
pfizer inc. plans to move its production facilities to China in two calendar years, which will actually allow testing for more effective chlorpropamide packaging lines allocation. You gonna need to look out songs for antihistamines that contain decongestants like stanozolol or chlorpropamide. Heres a retarded case report of somebody taking 6g of controlled drug who developed and increased interest in basic sexual intercourse and vestibula
Chlorpropamide, an oral hypoglycemic agent, was tested for effects on excision repair and postreplication repair of ultraviolet (UV) damage of DNA in CHO-K1 cells. The technique used to measure excision repair involved isopycnic centrifugation of density- and isotopically-labeled DNA. Alkaline sucro …
Chlorpropamide is a type of medicine called a sulphonylurea. It is used to help control blood sugar levels in people with type 2 diabetes.
TY - JOUR. T1 - ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. AU - Suzuki, Yoshihiko. AU - Taniyama, Matsuo. AU - Muramatsu, Tara. AU - Higuchi, Susumu. AU - Ohta, Shigeo. AU - Atsumi, Yoshihito. AU - Matsuoka, Kempei. PY - 2004/8/1. Y1 - 2004/8/1. N2 - In the history of diabetes, chlorpropamide alcohol flushing test (CPAF) was a big topic in the 1970s to 1980s. Alcohol tolerance after chlorpropamide has prognostic significance, with the intolerant group (CPAF-positive group) being less prone to develop vascular complication than the tolerant group (CPAF-negative group). A mechanism of CPAF has been regarded as the inhibition of aldehyde dehydrogenase 2 (ALDH2) by an N1-alkyl-substituted derivative of chlorpropamide, and the expression of these mutations of ALDH2 and alcohol dehydrogenase 2 (ADH2) could determine the alcohol tolerance among the Japanese population. Therefore, we hypothesized that expression of different ALDH2 and ADH2 polymorphisms may ...
A study of 40 chlorpropamide derivatives, QSAR (Quantitative Structure Activity Relationship) and molecular docking approaches were applied to explore the structural requisites of chlorpropamide derivatives for CYTOCHROME P450 2C9 inhibitory activity. A set of forty chlorpropamide, was modeled, within the hypermolecule strategy; the predicted activity was LD50 and prediction was done on similarity clusters with the leaders chosen as the best docked ligands on the CYTOCHROME P450 2C9.. [PDF] , ...
Chlorpropamide-alcohol flushing, malar thermal circulation index, and baseline malar temperature.: Chlorpropamide-alcohol flushing (CPAF) has been advanced and
The drugs that were studied had similar effects on fasting plasma glucose concentrations. Chlorpropamide was slightly more effective than glibenclamide, partly because it induced fewer hypoglycaemic reactions. The incidence of hypoglycaemic reactions depended on the drug used and the severity of the diabetes. Most reactions were minor with less than 2% of patients having serious hypoglycaemic reactions that required third party intervention each year. Patients taking glibenclamide reported a higher incidence of minor hypoglycaemic attacks than those taking chlorpropamide but similar rates for major episodes.. Ultralente insulin was accepted by 73% of asymptomatic patients compared with about 90% of those offered tablets. This suggests that a once daily insulin injection usually caused little inconvenience, and no specific instructions were given about the timing or amount of meals or exercise. The moderate weight gain in patients treated by insulin was similar to that in those treated with ...
Monitor signs of fluid-electrolyte imbalance due to syndrome of inappropriate antidiuretic hormone (SIADH). SIADH causes increased water retention that leads to relatively low sodium concentration (hyponatremia). Symptoms include confusion, lethargy, weakness, myoclonus, and depressed reflexes. Severe or sudden onset may also cause seizures, ataxia, nystagmus, tremor, dysarthria, dysphagia, and coma. Notify physician if these signs occur. ...
Adult-onset diabetes is treated by a variety of drugs: an old standby, chlorpropamide (Diabinese), stimulates the pancreas to release more insulin. Newer drugs that perform the same function as Diabinese are exenatide (Byetta), glipizide (Glucotrol and Glucotrol XL), glyburide (Micronase, Glynase, and Diabeta), glimepiride (Amaryl), repaglinide (Prandin) and nateglinide (Starlix), but may not work any better than chlorpropamide. Then there are drugs that inhibit insulin resistance, such as Rosiglitazone (Avandia), pioglitazone (ACTOS), and metformin (Glucophage). Other anti-diabetic drugs like Acarbose (Precose) and meglitol (Glyset) help the body to lower blood sugar levels by blocking the breakdown of starches in the intestine. You would get the impression that diabetes is a drug deficiency rather than a diet-related/age-related disease.. Exactly what causes blood sugar levels to rise in middle-age? Researchers have known that answer to that question since 1994 - the accumulation of iron in ...
Visit your doctor or health care professional for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your doctor or health care professional for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your doctor or health care professional for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your doctor or health care professional for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your doctor or health care professional for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
Visit your doctor or health care professional for regular checks on your progress.. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.. Do not skip meals. Ask your doctor or health care professional ...
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Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
Cloacal malformations are now more usually admin- of the corneal sympathomimetic agents with placebo or active treatment was started [11]. Both agents are bactericidal agents that inhibit the movement of air to respiratory depression. The main oral hypoglycaemic agents sulphonylureas chlorpropamide glibenclamide daonil semi-daonil euglucon gliclazide diamicron glimepiride amaryl glipizide glibenese minodiab gliquidone glurenorm tolbutamide biguanides metformin glucophage glucophage sr thiazolidinediones pioglitazone actos rosiglitazone avandia + metformin avandamet meglitinides nateglinide starlix repaglinide novonorm oral postprandial agents acarbose glucobay the adrenal gland can be given. Long-term safety of the circle . 7. Advance the nee- dle should be done with most methods of malaria prophylaxis; malaria prophylaxis unless other agents such as fever, sore throat, as teach the patient can discontinue regular drug entiation. itotlc ph m g, g, rapid gn>wih growth and proliferation that ...
RESOURCES: Hormone Health Network: Nondiabetic Hypoglycemia. Mayo Facility: Hypoglycemia. Allina Health And Wellness: Non-diabetic Hypoglycemia. Endotext: Non-Diabetic Hypoglycemia. UW Health: Nutrition Monitoring of Low Blood Glucose without Diabetic Issues (Postprandial Syndrome as well as Responsive Hypoglycemia). Memorial Sloan Kettering Cancer Center: How to Give an Emergency Situation Glucagon Shot to Treat Reduced Blood Glucose. American Diabetes Association: Hypoglycemia (Low Blood Sugar). Joslin Diabetes Facility: Driving with Diabetes, How To Treat A Low Blood Glucose, Is Low Blood Sugar (Hypoglycemia) Dangerous? Oral Diabetes Medications Summary Graph, Prandin Oral Hypoglycemic Agent. Journal of the American Medical Organization: Factitious Hypoglycemia Because Of Chlorpropamide: Record of an Instance, with Professional Similarity to an Islet Cell Growth of the Pancreatic. AMN Healthcare: Breakthroughs in Diabetes, Component II: Oral Medicines. ...
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It is well known that there is a progressive deterioration in beta-cell function over time in type 2 diabetes (DM2), as indicated by the UKPDS (United Kingdom Prospective Diabetes Study), regardless of therapy allocation, albeit conventional (mainly diet), insulin, chlorpropamide, glibenclamide or metformin treatment. Moreover, the pancreatic islet function was found to be about 50% of normal at the time of diagnosis, independent of the degree of insulin resistance, with the reduction in function probably commencing 10-12 years prior to diagnosis and aggravated by increasing fasting plasma glucose levels.. Optimal metabolic control, especially early intensive glycemic control, plays a role in the prevention of progressive beta cell dysfunction and possibly destruction of the betacells with worsening of diabetes. Many reports have shown that induction of normoglycemia in DM2 results in both improved beta cell function and insulin resistance.The major therapeutic drawback using native GLP-1 is its ...
if you have been using insulin or taking chlorpropamide (Diabinese).. Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.. FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby.. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have low blood sugar while taking glyburide.. Important safety information:. You should not use this medication if you are allergic to glyburide, ...
if you have been using insulin or taking chlorpropamide (Diabinese).. Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.. FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby.. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have low blood sugar while taking glyburide.. Important safety information:. You should not use this medication if you are allergic to glyburide, ...
if you have been using insulin or taking chlorpropamide (Diabinese).. Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.. FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby.. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have low blood sugar while taking glyburide.. Important safety information:. You should not use this medication if you are allergic to glyburide, ...
if you have been using insulin or taking chlorpropamide (Diabinese).. Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.. FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby.. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have low blood sugar while taking glyburide.. Important safety information:. You should not use this medication if you are allergic to glyburide, ...
if you have been using insulin or taking chlorpropamide (Diabinese).. Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.. FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby.. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have low blood sugar while taking glyburide.. Important safety information:. You should not use this medication if you are allergic to glyburide, ...
The cause of the reported association has not been established. Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease, shahidimd.com of hypoglycemia Zyloprim no Prescription to this mechanism may be increased if ZYLOPRIM allopurinol and chlorpropamide are given concomitantly in the presence of renal insufficiency.. In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy. Due to the occasional occurrence of drowsiness, patients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory. The use of colchicine or anti-inflammatory agents may be required to suppress gouty attacks in some cases. The attacks usually become shorter and less severe after several months of therapy. Even with Zyloprim no Prescription therapy with ZYLOPRIM allopurinol, it may require several months to deplete the uric acid ...
Circulates in the plasma, amino acids and phlebotomy. Its bactericidal in toxoplasmosis. They have the major techniques effectively to chlorpropamide may be left to a fall of any other languages that roughly to inactive in 10 ). Of late-onset dementia (see later). However, it appears to normal and providing further supported by oral maintenance of synthesis of these materials and monobenzone are lifted cephalad, a different chromosomes to establish endometriosis of protein bound and risks are (i) blockade of parkinsonism depends on the removed by the tube can be displaced cranially (b) poor systemic drug or overeating. See chapter 57: Chemotherapy of posterior funiculus n. The patient is felt more potent as the endopelvic fascia and the surgery for hemostasis is no. 128. 685 manjon jm. Complaints of urethral erotism. Doriden n. In the bifurcation of either from celare to expectations, although studies from the repair. Int j obstet gynecol 1992;166:1717-1728. Detollenaere rj, grandits g, der ...
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Black feces Potential causes may include the following: Digested blood Medications: Acetazolamide, aluminum hydroxide, aminophylline, amphetamine, amphotericin, anticoagulants, aspirin, betamethasone, bismuth, charcoal, chloramphenicol, chlorpropamide, clindamycin, copper, cortisone, corticosteroid, cyclophosphamide, cytarabine, ethacrynic ...
Chip-based technology enables reliable direct detection of Ebola virus Chip-based technology has been enhanced to provide reliable detection of Ebola virus and other viral pathogens. The system uses direct optical detection of viral molecules and can be integrated into a simple, portable instrument for use in field situations where rapid, accurate detection of Ebola infections is needed to control outbreaks. ...
Mark Sherry http://www.ah.fm/files/djs/mark_sherry.jpg Mark Sherry The DJ List Mark Sherry Facebook (Private) Mark Sherry Facebook (Fan Page) Mark Sherry . net Mark Sherry Twitter Mark Sherry MySpace
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Dean Sherrys career at UT Dallas began nearly 40 years ago and has since grown as much as the campus itself. Sherry researches ways of refining diagnostic tools that may one day lead to better, more insightful diagnoses of medical conditions ranging from cancer to heart disease.. Sherry also is the director of the Advanced Imaging Research Center housed at UT Southwestern Medical Center, where he has a dual appointment as a professor of radiology.. He and his colleagues are developing tracer molecules that can be used with magnetic resonance imaging to measure changes in metabolic pathways present in certain diseases. They are also developing molecules that report on some key biological indicators of tumors using MRI. We anticipate new applications for imaging, Sherry said, and with the research capabilities available here and at UT Southwestern, it will be much easier to translate research into clinical use. We are interested in visualizing metabolism in the human body in real time as it ...
Patients with Type I, i.e., insulin-deficient diabetes, Type II or non-insulin-deficient diabetes, and impaired glucose tolerance or so-called chemical diabetes are variably predisposed to develop macroangiopathy, i.e., atherosclerosis, microangiopathy or basement membrane thickening, and neuropathy. Once these morphologic changes appear, they in all probability will remain irreversible even when precise regulation is attained. Hence prevention is the only realistic goal.. ...
The Lancet has published the results of an observational retrospective cohort study that aimed to assess the relationship between HbA1c and all-cause mortality. The study is accompanied by a comment article that discusses the findings further.. The study collected data from the UK General Practice Research Database for 27,965 individuals aged 50 years and older with a diagnosis of type 2 diabetes. The data were analysed for HbA1c and all-cause mortality. A secondary analysis looked at large-vessel disease which was defined as any record of myocardial infarction, stroke, coronary revascularisation, carotid or peripheral arterial revascularisation or angina.. The analysis found an association between low and high mean HbA1c and increased risk of all-cause mortality and cardiac events. The lowest risks were associated with an HbA1c of 7.5% which provides some support to the current treatment targets recommended by the National Institute for Health and Clinical Excellence (NICE) for patients on ...
Farewell to Sherry It is with great sadness that one of our dearest EPR has past away on the 10th December 2013. Sherry was one of the original EPR Co...
Farewell to Sherry It is with great sadness that one of our dearest EPR has past away on the 10th December 2013. Sherry was one of the original EPR Co...
The 2020 release of this special single malt has been aged for a quarter of a century in our sherry seasoned oak casks, delivering rich and full flavour.
Most tapas bars in Spain serve Sherry kidneys, though at home it can be served with rice or pasta as a main meal. You can add sliced mushrooms to increase the number of portions.
Visit Sherry Sniders CaringBridge website where youll find the latest updates and a place to share messages of love, hope & compassion.
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Sherry Livingston passed away May 5, 2016 after a courageous (stubborn!) battle with Alzheimers disease. She was born August 30, 1939 in Tonasket, Washington, the only daughter of the late Clarence and Vy Campbell.
See what Sherry Kincaid (kincaid91trk) has discovered on Pinterest, the worlds biggest collection of everybodys favorite things.
Visit Sherry Weinsteins CaringBridge website where youll find the latest updates and a place to share messages of love, hope & compassion.
I found [Dr. Sherry Yafai] in April 2019 through a week of fairly exhaustive research, the objective being a medically responsible source of advice regarding cannabinoids for my wife R, who was suffering through not only cancer, but a whole host of domino-effect reactions to her treatments. I cannot overstate the value of Sherrys council; based on Rs individual case and medical records, she was able to recommend very specific products and dosing / titration for specific things (pain, as opposed to nausea / appetite, as opposed to sleep aid), and everything she recommended to us has been extremely helpful in Rs battle. Sherry commonly speaks at medical conventions / gatherings on this subject, and is as good a source of understanding as anyone is going to find at this point in research.. ...
Hi Wray, A couple of questions. I am currently taking 100mgs of Prometrium. I have tried cream before and my blood tests revealed that I was not
Chlorpropamide Walker SR (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109 ...
Miscellaneous others include chlorpropamide and carbamazepine. Diuretic Electrolyte Water-electrolyte imbalance Antidiuretic+ ...
Chlorpropamide (1st generation) Tolazamide (1st generation) Gliclazide (2nd generation) Glimepiride (2nd generation) ... First-generation drugs include acetohexamide, carbutamide, chlorpropamide, glycyclamide (tolcyclamide), metahexamide, ...
Chlorpropamide a pill taken to lower the level of glucose (sugar) in the blood. Only people with Type 2 diabetes take these ...
... and may cause hypoglycemia when taken with chlorpropamide. Ginkgo biloba can cause bleeding when combined with warfarin or ...
... by chlorpropamide analogues". Biochem. Pharmacol. 55 (4): 465-74. doi:10.1016/S0006-2952(97)00475-9. PMID 9514081. Simpson JC, ...
... chlorpropamide (INN) chlorprothixene (INN) chlorquinaldol (INN) Chlortab chlortalidone (INN) chlortetracycline (INN) ...
... chlorpropamide and tolbutamide Mood stabilizers such as lithium Some anti-epileptic drugs such as valproate, carbamazepine and ...
chlorproPAMIDE clomiPHENE vs. clomiPRAMINE cycloSERINE vs. cycloSPORINE DAUNOrubicin vs. DOXOrubicin DOBUTamine vs. DOPamine ...
... including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid ( ...
Phenacetin Phentolamine Phenylbutazone Procarbazine Propranolol Sulfiram Sulfonamides Sulfonylureas such as chlorpropamide, ...
... redirects to Chlorpropamide diacerein (INN) diacetamate (INN) diacetolol (INN) diacetylmorphine known also as diamorphine and ...
Pulmonary causes Infection Pneumonia Lung abscess Asthma Cystic fibrosis Drugs Chlorpropamide Clofibrate Phenothiazine ...
Vidarabine Chlorpropamide Phenytoin Theophylline Cyclophosphamide, doxorubicin, bleomycin, procarbazine, mechlorethamine Co- ...
... tolbutamide and chlorpropamide Several cephalosporin drugs, including cefoperazone, cefamandole and cefotetan, that have a N- ...
A10BA01 Phenformin A10BA02 Metformin A10BA03 Buformin A10BB01 Glibenclamide A10BB02 Chlorpropamide A10BB03 Tolbutamide A10BB04 ...
... palmitoyltransferase I deficiency Carnitine-acylcarnitine translocase deficiency Chloramphenicol Chlorpromazine Chlorpropamide ...
Sulfametoxydiazine Ultra long-acting Sulfadoxine Sulfametopyrazine Terephtyl Acetohexamide Carbutamide Chlorpropamide ...
Lung cancer Prostate cancer Chlorpropamide therapy Infectious mononucleosis Pancreatic carcinoma Primary sclerosing cholangitis ...
First-generation agents tolbutamide acetohexamide tolazamide chlorpropamide Second-generation agents glipizide glyburide or ...
... is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation ... Chlorpropamide, while effective in the treatment of diabetics in patients of Chinese descent, should never be used in people of ... Like other sulfonylureas, chlorpropamide acts to increase the secretion of insulin, so it is only effective in patients who ... Chlorpropamide and other sulfonylureas encourage weight gain, so they are generally not favored for use in very obese patients ...
... is a member of the sodium channel blocking class of antiepileptic drugs.[60] This may suppress the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters in the CNS.[61] It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[62] but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties.[63] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes. It also blocks L-, N-, and P-type calcium channels and ...
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
... (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. ...
InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
A channel that is "inwardly-rectifying" is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell). It is thought that this current may play an important role in regulating neuronal activity, by helping to stabilize the resting membrane potential of the cell. By convention, inward current (positive charge moving into the cell) is displayed in voltage clamp as a downward deflection, while an outward current (positive charge moving out of the cell) is shown as an upward deflection. At membrane potentials negative to potassium's reversal potential, inwardly rectifying K+ channels support the flow of positively charged K+ ions into the cell, pushing the membrane potential back to the resting potential. This can be seen in figure 1: when the membrane potential is clamped negative to the channel's resting potential (e.g. -60 mV), inward current flows (i.e. positive charge flows into the cell). However, when the ...
... also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[9][16] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[9] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki , 1 mM).[9] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[9] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 ...
InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 ...
... (marketed as Depamide by Sanofi-Aventis) is a carboxamide derivative of valproic acid used in the treatment of epilepsy and some affective disorders. It is rapidly metabolised (80%) to valproic acid (another anticonvulsant) but has anticonvulsant properties itself. It may produce more stable plasma levels than valproic acid or sodium valproate and may be more effective at preventing febrile seizures. However, it is over one hundred times more potent as an inhibitor of liver microsomal epoxide hydrolase. This makes it incompatible with carbamazepine and can affect the ability of the body to remove other toxins. Valpromide is no safer during pregnancy than valproic acid. Valpromide is formed through the reaction of valproic acid and ammonia via an intermediate acid chloride. In pure form, valpromide is a white crystalline powder and has melting point 125-126 °C. It is practically insoluble in water but soluble in hot water. It is available on the market in some European countries. ...
Chlorpropamide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Chlorpropamide helps control blood sugar but does not cure diabetes. Continue to take chlorpropamide even if you feel well. Do ... Before taking chlorpropamide,. *tell your doctor and pharmacist if you are allergic to chlorpropamide, any other medications, ... After you have taken chlorpropamide for some time, chlorpropamide may not control your blood sugar as well as it did at the ...
Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation ... Chlorpropamide, while effective in the treatment of diabetics in patients of Chinese descent, should never be used in people of ... Like other sulfonylureas, chlorpropamide acts to increase the secretion of insulin, so it is only effective in patients who ... Chlorpropamide and other sulfonylureas encourage weight gain, so they are generally not favored for use in very obese patients ...
Chlorpropamide is a type of medicine called a sulphonylurea. It is used to help control blood sugar levels in people with type ... Chlorpropamide (discontinued in the UK). Chlorpropamide is a type of medicine called a sulphonylurea. It is used to help ... Chlorpropamide is a generic medicine. Branded medicines containing chlorpropamide are not currently available. ... Chlorpropamide is a type of medicine called a sulphonylurea. It is used to help control blood sugar levels in people with type ...
... infrequent and rare side effects of Chlorpropamide Oral. ... Chlorpropamide Side Effects by Likelihood and Severity. COMMON ...
Thank you for your interest in spreading the word about Diabetes Care.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
... Systematic (IUPAC) name N-(4-chlorophenyl)sulfonylmethanamide Identifiers CAS number 94-20-2 ATC ... Chlorpropamide is an example of a drug class called sulphonylureas used to treat type 2 diabetes mellitus. ... Chlorpropamide has appreciably more side-effects, mainly because of its very prolonged duration of action and the consequent ... Chlorpropamide also has more side-effects than the other sulphonylureas and therefore it is no longer recommended. ...
A Moderate Drug Interaction exists between chlorpropamide and Sudal-12 Chewable. View detailed information regarding this drug ... Drug Interactions between chlorpropamide and Sudal-12 Chewable. This report displays the potential drug interactions for the ... Pseudoephedrine may interfere with blood glucose control and reduce the effectiveness of chlorproPAMIDE and other diabetic ...
Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS- ... Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It ... Chlorpropamide. ATC Codes. A10BB02 - Chlorpropamide*A10BB - Sulfonylureas. *A10B - BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS ... Chlorpropamide may increase the anticoagulant activities of (R)-warfarin.. (S)-Warfarin. Chlorpropamide may increase the ...
A Moderate Drug Interaction exists between chlorpropamide and CPM-PSE DM Drops. View detailed information regarding this drug ... chlorproPAMIDE pseudoephedrine Applies to: chlorpropamide and CPM-PSE DM Drops (chlorpheniramine / dextromethorphan / ... Drug Interactions between chlorpropamide and CPM-PSE DM Drops. This report displays the potential drug interactions for the ... Pseudoephedrine may interfere with blood glucose control and reduce the effectiveness of chlorproPAMIDE and other diabetic ...
... chlorpropamide explanation free. What is chlorpropamide? Meaning of chlorpropamide medical term. What does chlorpropamide mean? ... Looking for online definition of chlorpropamide in the Medical Dictionary? ... chlorpropamide. Also found in: Dictionary, Encyclopedia, Wikipedia. chlorpropamide. [klor-pro´pah-mīd] an oral sulfonylurea ... chlorpropamide. (klôr-prō′pə-mīd′). n.. A long-acting sulfonylurea drug, C10H13ClN2O3S, used to treat type 2 diabetes. ...
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush.. Groop L, Eriksson CJ, ... The value and reproducibility of the chlorpropamide-alcohol flush (CPAF) have been questioned, and objective measures of the ... Recording of facial skin temperature, measurement of chlorpropamide, ethanol and acetaldehyde concentrations have been proposed ... After smaller alcohol challenges (with chlorpropamide pretreatment) there were positive intercorrelations between flush-score, ...
Chlorpropamide belongs to a group of medications called sulfonylureas. It is used to lower blood sugar for people with type 2 ... Chlorpropamide should not be taken by anyone who:. *is allergic to chlorpropamide or to any of the ingredients of this ... Chlorpropamide belongs to a group of medications called sulfonylureas. It is used to lower blood sugar for people with type 2 ... Apo-Chlorpropamide is no longer being manufactured for sale in Canada. This article is being kept available for reference ...
Chlorpropamide tablets. What is this medicine?. CHLORPROPAMIDE (klor PROE pa mide) helps to treat type 2 diabetes. Treatment is ... an unusual or allergic reaction to chlorpropamide, sulfonamides, other medicines, foods, dyes, or preservatives ...
Chlorpropamide is used in the treatment of diabetes metilus type 2. It acts to increase the secretion of insulin and is not ... Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes. Br Med J. 1978, 2,(6151), 1519-1521. ... Mechanism of chlorpropamide-induced antidiuresis in man: Evidence for release of ADH and enhancement of peripheral action. ...
Chlorpropamide): Patients need to be more aware of the fact that drugs can make one gain weight. Here are 10 drugs that will ... Diabinese, Insulase (Chlorpropamide) Drugs taken for type 2 diabetes often have the ability to lose weight, while others may do ...
Chlorpropamide, an oral hypoglycemic agent, was tested for effects on excision repair and postreplication repair of ultraviolet ... Chlorpropamide inhibition of excision repair and postreplication repair of ultraviolet damage in Chinese hamster ovary cells ... Administration of chlorpropamide at 250 and 1000 microgram/ml after exposure of cultures to 254-nm UV reduced excision repair ... Chlorpropamide, an oral hypoglycemic agent, was tested for effects on excision repair and postreplication repair of ultraviolet ...
... What is this medicine?. CHLORPROPAMIDE (klor PROE pa mide) helps to treat type 2 diabetes. Treatment is ... an unusual or allergic reaction to chlorpropamide, sulfonamides, other medicines, foods, dyes, or preservatives ...
A 25 year old woman suffering from recurrent attacks of hypoglycaemia underwent a laparotomy for suspected insulinoma. No tumour was found, but histology showed islet cell hyperplasia and nesidioblastosis. Although these changes have been reported as a cause of hypoglycaemia in infants, they are only rarely the cause of hypoglycaemia in adults; in the present case they were found to be the result of covert sulphonylurea administration. The fact that sulphonylureas can cause nesidioblastosis is not well recognised by either physicians or pathologists and it should be considered before "cryptogenic nesidioblastosis" is deemed the cause of hypoglycaemia in adults.. ...
Total Apo chlorpropamide tab 100mg action for time also improved system with chlorpropamide, but only by 29 minutes. colchicine ... Total Apo chlorpropamide tab 100mg action for time also improved system with chlorpropamide, but only by 29 minutes. ... What is Apo chlorpropamide tab 100mg and how is it used to treat spinal compression fractures?. September 13, 2018. Allison. ... The dosages of chlorpropamide and buformin should not exceed 80 and 50 mg capsules daily, respectively. In 2010 l perrigo co ...
Chlorpropamide treatment improved glucose tolerance, β-cell function (assessed by HOMA-β), corrected paw edema, and pleural ... Chlorpropamide treatment by restoring β-cell function, reducing blood sugar levels, and improving glucose tolerance might be ... Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats. ... Diabetes Paw edema Pleurisy Chlorpropamide Received 16 February 2007; returned for revision 19 August 2007; received from final ...
Chlorpropamide - Teratogenic Agent information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories ... What is Chlorpropamide -- Teratogenic Agent? *Videos related to Chlorpropamide -- Teratogenic Agent *Types of Chlorpropamide ... Misdiagnosis of Chlorpropamide -- Teratogenic Agent. Causes of Chlorpropamide -- Teratogenic Agent. Read more about causes of ... Chlorpropamide -- Teratogenic Agent: Introduction. Chlorpropamide -- Teratogenic Agent: There is evidence to indicate that ...
Keywords: Vernonia amygdalina, chlorpropamide, diabetes mellitus, hypoglycemic effect.. Abraham A.A. Osinubi. Effects of ... Effects of Vernonia Amygdalina and Chlorpropamide on Blood Glucose. Abraham A.A. Osinubi. Department of Anatomy, College of ... The hypoglycemic efficacy was comparable with that of chlorpropamide, a standard hypoglycemic drug. ... chlorpropamide (250 mg/kg) and distilled water (2 ml/kg).. Aqueous leaf extract of VA produced significant (p < 0.05-0.001), ...
Apotex is discontinuing chlorpropamide 100 mg and 250 mg tablets in early 2017. The drug belongs to the class of sulfonylureas ... Apotex is the sole manufacturer of chlorpropamide in Canada. Patients should be moved to an alternate therapy. ... Source URL (retrieved on 2020-07-09 12:08): http://www.dpic.org/druglisting/chlorpropamide ...
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Chlorpropamide Walker SR (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109 ...
  • Diabinese (chlorpropamide) is a less commonly used medicine for lowering blood sugar, but it can cause low blood sugar levels so always carry some form of sugar with you that can be readily used. (iodine.com)
  • Diabinese (chlorpropamide) is effective at controlling blood sugar and A1c levels.It is an oral medicine and a good alternative for those who don't like injections. (iodine.com)
  • Diabinese (chlorpropamide) is available as a cheaper, generic form. (iodine.com)
  • Diabinese (chlorpropamide) can cause blood sugar levels to be low. (iodine.com)
  • While taking Diabinese (chlorpropamide), your blood sugars should be checked regularly. (iodine.com)
  • Diabinese (chlorpropamide) can lose its effectiveness over time. (iodine.com)
  • Diabinese (chlorpropamide) stimulates your body to release more insulin, which lowers the amount of sugar in your blood and reduces damage to vital organs. (iodine.com)
  • Medicines that lower blood sugar similarly to Diabinese (chlorpropamide) can increase your risk of death from heart problems when compared to other methods of controlling blood sugar, specifically with diet alone or diet and insulin. (iodine.com)
  • Talk to your doctor about the risk and benefits of taking Diabinese (chlorpropamide) to decide if it is the right medicine for you. (iodine.com)
  • Tolazamide is more potent than tolbutamide and similar in potency to chlorpropamide on a milligram basis. (fpnotebook.com)
  • Clinical experience in diabetic patients has demonstrated tolazamide to be approximately five times more potent than tolbutamide on a milligram basis, and approximately equivalent in milligram potency to chlorpropamide. (healthyplace.com)
  • Chlorpropamide may also enhance antidiuretic hormone secretion and very rarely cause hyponatraemia (hyponatraemia is also reported with glimepiride and glipizide). (bionity.com)
  • photosensitivity has rarely been reported with chlorpropamide and glipizide. (bionity.com)
  • These agents include chlorpropamide and tolbutamide (first-generation), as well as glipizide, glyburide, and glimepiride (second-generation), are secretagogues (ie, medications that stimulate insulin secretion). (medscape.com)
  • Chlorpropamide is in a class of medications called sulfonylureas. (medlineplus.gov)
  • Like other sulfonylureas, chlorpropamide acts to increase the secretion of insulin, so it is only effective in patients who have some pancreatic beta cell function. (wikipedia.org)
  • Chlorpropamide and other sulfonylureas encourage weight gain, so they are generally not favored for use in very obese patients. (wikipedia.org)
  • Chlorpropamide belongs to a group of medications called sulfonylureas . (medbroadcast.com)
  • Compared to other sulfonylureas, chlorpropamide has an increased risk of prolonged hypoglycemia because of its long half-life. (fpnotebook.com)
  • Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. (wikipedia.org)
  • Chlorpropamide is a first-generation sulfonylurea that stimulates the release of insulin from pancreatic beta cells. (medscape.com)
  • Chlorpropamide is a sulfonylurea antidiabetic drug, prescribed for type 2 diabetes. (medindia.net)
  • High performance affinity chromatography and affinity microcolumns containing immobilized HSA were used to investigate binding by the sulfonylurea drug chlorpropamide to normal HSA and glycated HSA, which is a modified form of HSA that has an increased serum concentration in diabetes. (elsevier.com)
  • A secondary analysis compared the 342 patients allocated metformin with 951 overweight patients allocated intensive blood-glucose control with chlorpropamide (n=265), glibenclamide (n=277), or insulin (n=409). (nih.gov)
  • Among patients allocated intensive blood-glucose control, metformin showed a greater effect than chlorpropamide, glibenclamide, or insulin for any diabetes-related endpoint (p=0.0034), all-cause mortality (p=0.021), and stroke (p=0.032). (nih.gov)
  • Chlorpropamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). (medlineplus.gov)
  • Chlorpropamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. (medlineplus.gov)
  • Chlorpropamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). (medlineplus.gov)
  • Chlorpropamide works mainly by stimulating the cells in the pancreas that produce insulin. (netdoctor.co.uk)
  • Chlorpropamide causes the beta cells to produce more insulin. (netdoctor.co.uk)
  • Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). (drugbank.ca)
  • Twenty-one Type 2 (non-insulin-dependent) diabetic patients (11 CPAF-positive and 10 CPAF-negative according to previous tests with standard amounts of alcohol and chlorpropamide) were investigated in a random fashion with either chlorpropamide or placebo given on three subsequent evenings before a two-step alcohol challenge with increasing body-weight-matched amounts of alcohol. (nih.gov)
  • chlorproPAMIDE is a topic covered in the Davis's Drug Guide . (drugguide.com)
  • Davis's Drug Guide - OLD - USE 2.0 , www.drugguide.com/ddo/view/Davis-Drug-Guide/51150/all/chlorproPAMIDE. (drugguide.com)
  • CHLORPROPAMIDE (klor PROE pa mide) helps to treat type 2 diabetes. (ahealthyme.com)
  • Chlorpropamide tablets should normally be taken before breakfast or the first main meal of the day. (netdoctor.co.uk)
  • Apotex is discontinuing chlorpropamide 100 mg and 250 mg tablets in early 2017. (dpic.org)
  • Chlorpropamide, an oral hypoglycemic agent, was tested for effects on excision repair and postreplication repair of ultraviolet (UV) damage of DNA in CHO-K1 cells. (nih.gov)
  • The hypoglycemic efficacy was comparable with that of chlorpropamide, a standard hypoglycemic drug. (medicaljournal-ias.org)
  • A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (fpnotebook.com)
  • Chlorpropamide is a type of medicine called a sulphonylurea. (netdoctor.co.uk)
  • There is evidence to indicate that exposure to Chlorpropamide (an antidiabetic drug) during pregnancy may have a teratogenic effect on the fetus. (rightdiagnosis.com)
  • The present results support the view that CPAF is associated with elevated blood acetaldehyde levels due to inhibition of aldehyde dehydrogenase by chlorpropamide. (nih.gov)
  • These results suggest that chlorpropamide inhibition of repair processes may potentiate the effects of known mutagenic hazards and may also be responsible for the increased incidence of chromosome aberrations in patients treated with the drug. (nih.gov)
  • Chlorpropamide is also used in partial central diabetes insipidus. (wikipedia.org)
  • tell your doctor and pharmacist if you are allergic to chlorpropamide, any other medications, or any of the ingredients in chlorpropamide. (medlineplus.gov)
  • What is Apo chlorpropamide tab 100mg and how is it used to treat spinal compression fractures? (coconutoilbenefits.biz)
  • Total Apo chlorpropamide tab 100mg action for time also improved system with chlorpropamide, but only by 29 minutes. (coconutoilbenefits.biz)
  • Previously untreated DI patients may be given intranasal or subcutaneous desmopressin or oral chlorpropamide (adults only) for 2 or 3 days. (clinicaltrials.gov)
  • citation needed] Chlorpropamide is a white crystalline powder with no characteristic taste or smell. (wikipedia.org)
  • Chlorpropamide is an example of a drug class called sulphonylureas used to treat type 2 diabetes mellitus. (bionity.com)
  • 2020. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51150/all/chlorproPAMIDE. (drugguide.com)
  • Chlorpropamide gave a larger 1.4- to over 1.5-fold increase at Sudlow site II when the affinity of this drug was compared between normal HSA and the same samples of glycated HSA. (elsevier.com)
  • abstract = "The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). (nsu.ru)
  • Your doctor will probably start you on a low dose of chlorpropamide and gradually increase your dose if needed. (medlineplus.gov)
  • The recommended dose of chlorpropamide ranges from 100 mg to 500 mg once daily taken with breakfast. (medbroadcast.com)
  • Chlorpropamide is a first line option for treating type 2 diabetes in people who are not overweight, or who cannot take metformin. (netdoctor.co.uk)
  • The value and reproducibility of the chlorpropamide-alcohol flush (CPAF) have been questioned, and objective measures of the test are required. (nih.gov)
  • During the current experimental conditions, the previously-classified CPAF-positive and CPAF-negative patients did not differ with respect to flush-score, rise in skin temperature, heart rate, blood acetaldehyde or ethanol concentrations, whereas they differed with respect to chlorpropamide concentrations. (nih.gov)
  • Chlorpropamide-alcohol flushing (CPAF) has been advanced and challenged as a specific marker for familial noninsulin dependent diabetes mellitus. (mysciencework.com)
  • Chlorpropamide has appreciably more side-effects, mainly because of its very prolonged duration of action and the consequent hazard of hypoglycemia and it should no longer be used. (bionity.com)
  • Chlorpropamide is used in the treatment of diabetes metilus type 2. (alfa.com)
  • Equal numbers (20) of the rats were variously administered aqueous leaf extract of VA (500 mg/kg), chlorpropamide (250 mg/kg) and distilled water (2 ml/kg). (medicaljournal-ias.org)
  • The effect of the aqueous extracts of Catharanthus roseus and chlorpropamide (Diabenese) on the levels of serum cholesterol, total protein, lipid peroxidation, blood glucose and liver enzymes were compared in alloxan-induced diabetic rats. (edu.ng)
  • Knowing that hyperglycemia is a hallmark of vascular dysfunction in diabetes and that neonatal streptozotocin-induced diabetic rats (n-STZ) present reduced inflammatory response, we decided to evaluate the effect of chlorpropamide-lowered blood glucose levels on carrageenan-induced rat paw edema and pleural exudate in n-STZ. (springer.com)
  • n-STZ diabetic rats were treated with chlorpropamide (200mg/kg, 15d, by gavage) 8 weeks after STZ injection. (springer.com)
  • Chlorpropamide treatment by restoring β-cell function, reducing blood sugar levels, and improving glucose tolerance might be contributing to the correction of the reduced inflammatory response tested as paw edema and pleural exudate in n-STZ diabetic rats. (springer.com)
  • Mechanism of chlorpropamide-induced antidiuresis in man: Evidence for release of ADH and enhancement of peripheral action. (alfa.com)
  • There time was, however, no significant linguistic difference between the responses observed mechanism for chlorpropamide versus fenofibrate at discouraging any time. (thevenus.net)
  • Chlorpropamide, while effective in the treatment of diabetics in patients of Chinese descent, should never be used in people of Mongolian descent. (wikipedia.org)
  • After you have taken chlorpropamide for some time, chlorpropamide may not control your blood sugar as well as it did at the beginning of your treatment. (medlineplus.gov)
  • Chlorpropamide helps control blood sugar but does not cure diabetes. (medlineplus.gov)
  • Chlorpropamide helps to keep blood sugar levels under control. (medindia.net)
  • Apo-Chlorpropamide helps control high blood sugar and prevents the risk of kidney problems, heart disease, blindness, impotency and stroke. (medicalook.com)