Chlorphentermine
Phentermine
Lipidoses
Diethylpropion
Fenfluramine
Dexfenfluramine
DDT
A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)
Dichlorodiphenyldichloroethane
Encyclopedias as Topic
Methenamine
Phenazopyridine
Pneumocystis
Drug and Narcotic Control
Viola
Central Nervous System
Central Nervous System Stimulants
Depression, Chemical
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Plants, Medicinal
United States Department of Agriculture
A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.
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Methyltestosterone
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Methane
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Secobarbital
Amobarbital
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Barbiturates
Athletic Performance
Great Lakes Region
Eicosapentaenoic Acid
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Fishes
Hindlimb Suspension
Doping in Sports
Sports Medicine
Phenylpropanolamine
Ephedrine
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Ephedra
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (1/6)
BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders. (+info)The metabolism, distribution and elimination of chlorphentermine in man. (2/6)
1 A gas-liquid chromatography procedure for the determination of chlorphentermine (I), N-hydroxychlorphentermine (II) and alpha,alpha-dimethyl-alpha-nitro-beta-(4-chlorophenyl)ethane (IV) in urine has been developed. Also methods are reported to determine conjugated II and the total N-oxidized metabolites of I, i.e. II, conjugated II, alpha,alpha-dimethyl-alpha-nitroso-beta-(4-chlorophenyl)ethane (III) and IV in urine. 2 The synthesis of alpha,alpha-dimethyl-alpha-nitroso-beta-(4-chlorophenyl)ethane (III) and its properties are reported. 3 The kinetics of urinary excretion of I and its metabolic products after the oral administration of I to a human subject on separate occasions have been studied. Under normal conditions of urinary pH, metabolism by N-oxidation was the main elimination route of I; acidifying the urine increased the urinary excretion of unchanged I at the expense of the N-oxidized products. 4 The importance of the N-oxidation metabolic route in the distribution of chlorphentermine (I) in man is discussed. (+info)N-[11C-Methyl]chlorphentermine and N,N-[11C-dimethyl]chlorphentermine as brain blood-flow agents for positron emission tomography. (3/6)
N-[11C-methyl]chlorphentermine ([11C]NMCP) and N,N-[11C-dimethyl]chlorphentermine ([11C]NDMCP) were prepared from chlorphentermine and 11CH3I in DMF and evaluated in rats as brain blood-flow agents for positron emission tomography (PET). Tissue distribution of [11C]NMCP showed that brain uptake was 2.70 +/- 0.40% of injected dose per organ at 5 min with no change in radioactivity concentration up to 30 min after i.v. injection. Approximately 80% of the initial brain uptake remained at 60 min. On the other hand, initial brain uptake of [11C] NDMCP (3.66 +/- 0.31 and 3.63 +/- 0.88% injected dose per organ at 5 and 15 min, respectively) was greater than that of [11C]NMCP. The brain activity however, rapidly decreased to 2.38 +/- 0.17 and 1.82 +/- 0.32% at 30 and 60 min, respectively. Because of its longer retention in the brain compared with [11C]NDMCP, [11C]NMCP would be a potential brain blood-flow agent for quantitative PET studies. (+info)Fluorescence studies of the binding of amphiphilic amines with phospholipids. (4/6)
The binding characteristics of several amine drugs with dispersed phospholipids (phosphatidylcholine, phosphatidylserine, and phosphatidylglycerol) have been studied using the fluorometric method and 1-anilino-8-naphthalene sulfonate and 1,6 diphenyl-1,3,5-hexatriene as fluorescence probes. The results show that amphiphilic amines, such as chlorphentermine, interact with phospholipids via both ionic and hydrophobic forces. The ionic interaction, which occurs between the protonated amine group of the drug and the phosphate oxygen of the lipid, changes the amphiphilic characteristics of the lipid by reducing the number of negative charges on the lipid vesicles, and inhibits the Ca2+-dependent lipid hydrolysis by blocking the Ca2+ binding sites on the lipid vesicles. The hydrophobic interaction, which involves the nonpolar moieties of the drug and the lipid, is of primary importance to the overall drug-lipid binding stability. Drugs without a strong hydrophobic moiety, such as dopamine, do not interact with phospholipids. (+info)Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats. (5/6)
1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion).2 There was very little difference between the potencies of (+)- and (-)-amphetamine.3p-Chloromethamphetamine was a more potent aversive agent than methamphetamine.4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine.5 Cocaine induced only moderate taste aversions, even at high doses.6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action. (+info)Effect of chlorphentermine on the lipids of rat lungs. (6/6)
Chronic administration of chlorphentermine to rats resulted in a reduction of body weight compared to a normal control group. The weight of the heart, liver, kidney, and spleen was less in the treated group while the weight of the lungs was increased significantly. There was no change in the ratio of right ventricular to left ventricular weight in the rats treated with chlorphentermine, supporting the views that this drug does not cause pulmonary hypertension. Biochemical analysis showed that the increase in the weight of the lungs was due to the accumulation of phospholipid. All classes of phospholipid were affected, but particularly phosphatidyl choline, the tissue concentration of which increased nine times. Chlorphentermine also increased the proportion of palmitate present in pulmonary phosphatidyl choline. Histological examination of the lung after treatment with chlorphentermine showed evidence of this drug-induced lipidosis. No conclusion can as yet be reached as to the mechanism involved in the accumulation of phospholipid in the lung after chlorphentermine. (+info)
Chlorphentermine - Wikipedia
Shall we have a different look at hycomine with its connection to chlorphentermine
Chlorphentermine
Clortermine - Wikipedia
Kigezo:Stimulants - Wikipedia, kamusi elezo huru
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in...
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PH Study Identifies Blood-flow Measurements That Can Predict Patient Outcomes
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King Soopers - Irwin Naturals Steel-Libido Red Magnum Blood-Flow Nitric-Oxide Boost, 150 ct
Israels Ornim raises $20M for noninvasive continuous blood-flow monitor | FierceBiotech
Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET...
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Carmichael receives $100,000 grant to study vascular brain disease, Alzheimers
Clortermine
... produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it ...
3,4-Methylenedioxyphenethylamine
... ("3,4-MDPEA" or just "MDPEA"), also known as homopiperonylamine, is a substituted phenethylamine formed by adding a methylenedioxy group to phenethylamine. It is structurally similar to MDA, but without the methyl group at the alpha position. According to Alexander Shulgin in his book PiHKAL, MDPEA appears to be biologically inactive. This is likely because of extensive first-pass metabolism by the enzyme monoamine oxidase. However, if MDPEA were either used in high enough of doses (e.g., 1-2 grams), or in combination with a monoamine oxidase inhibitor (MAOI), it is probable that it would become sufficiently active, though it would likely have a relatively short duration of action. This idea is similar in concept to the use of selective MAOA inhibitors and selective MAOB inhibitors in augmentation of dimethyltryptamine (DMT) and phenethylamine (PEA), respectively. ...
3,4-Methylenedioxy-N-ethylamphetamine
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
3-Fluoromethcathinone
... (also known as 3-FMC) is a chemical compound of the phenethylamine, amphetamine, and cathinone classes that has been sold online as a designer drug.[1][2] It is a structural isomer of flephedrone (4-fluoromethcathinone). 3-Fluoroisomethcathinone is produced as a by-product when 3-FMC is synthesized, the activity of this compound is unknown.[3] ...
Naphyrone
... emerged as a new legal high in the United Kingdom only months after the ban of similar drug mephedrone (which was also a cathinone derivative). Until July 2010 the substance was not controlled by the Misuse of Drugs Act 1971 and was therefore not illegal for someone to possess. The Medicines Act prevented naphyrone from being sold for human consumption, and therefore it was sometimes sold as 'pond cleaner' or as another substance not normally consumed by humans. In response to this emerging trend of new designer drugs, Home Office Minister James Brokenshire said, "action to address the issue of emerging legal highs coming on to the market is a priority for the government."[12][unreliable source?] A study by researchers at Liverpool John Moores University found that only one out of ten products labelled as "NRG-1" actually contained naphyrone when they were subjected to laboratory analysis. Compounds found in products labelled NRG-1 included MDPV, flephedrone, mephedrone, butylone and ...
Desvenlafaxine
... is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar.[5] It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake.[6]. ...
Methylenedioxydimethylamphetamine
3,4-Methylenedioxy-N,N-dimethylamphetamine (MDDM) is a lesser-known psychedelic drug. It is also the N,N-dimethyl analog of 3,4-methylenedioxyamphetamine (MDA). MDDM was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the dosage is unspecified and the duration unknown. MDDM produces only mild effects that are not well characterized in PiHKAL. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDDM. This compound is however occasionally encountered as an impurity in 3,4-methylenedioxy-N-methylamphetamine (MDMA) which has been synthesized by methylation of MDA using methylating reagents such as methyl iodide. An excess of reagent or a reaction temperature that is too high results in some double methylation of the amine nitrogen, yielding MDDM as well as MDMA. The presence of MDDM as an impurity can thus reveal which synthetic route was used to manufacture seized samples of MDMA. ...
25I-NBOH
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
2,5-Dimethoxy-4-propylamphetamine
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
Etilevodopa
Djaldetti Ruth; Giladi Nir; Hassin-Baer Sharon; Shabtai Hertzel; Melamed Eldad (November-December 2003). "Pharmacokinetics of Etilevodopa Compared to Levodopa in Patient's With Parkinson's Disease: An Open-label, Randomized, Crossover Study". Clinical Neuropharmacology. 26 (6): 322-326. doi:10.1097/00002826-200311000-00012. PMID 14646613 ...
2-Fluoroamphetamine
... (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug.[1] 2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood-brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute.[2][3] ...
DiFMDA
Difluoromethylenedioxyamphetamine (DiFMDA) is a substituted derivative of 3,4-methylenedioxyamphetamine (MDA), which was developed by Daniel Trachsel and coworkers, along with the corresponding fluorinated derivatives of MDMA, MDEA, BDB and MBDB, with the aim of finding a non-neurotoxic drug able to be used as a less harmful substitute for entactogenic drugs such as MDMA. Since a major route of the normal metabolism of these compounds is scission of the methylenedioxy ring, producing neurotoxic metabolites such as alpha-methyldopamine, it was hoped that the difluoromethylenedioxy bioisostere would show increased metabolic stability and less toxicity.[1][2] These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non-fluorinated parent compounds, although in vitro binding studies show DFMDA to have a SERT affinity in between that of MDA and MDMA.[3] However, there is known to be a lack of bulk tolerance at this position of the ...
3,4-Methylenedioxy-N-methylphentermine
... (MDMP), or 3,4-methylenedioxy-α,α,N-trimethylphenethylamine, is a lesser-known psychedelic drug. MDMP was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the minimum dosage is listed as 110 mg, and the duration is listed as approximately 6 hours. MDMP produces few to no effects, and is slightly similar to MDMA. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDMP. ...
3,4-Methylenedioxy-N-methoxyamphetamine
... (MDMEO, MDMEOA, or MDMeOA) is a lesser-known psychedelic drug and a substituted amphetamine. It is also the N-methoxy analogue of MDA. MDMEO was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the minimum dosage is listed as 180 mg. MDMEO may be found as white crystals. It produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDMEO. ...
2C-T-2
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
N,alpha-Diethylphenylethylamine
N,α-Diethylphenylethylamine (N,α-DEPEA, 2-ethylamino-1-phenylbutane, EAPB) is a close chemical analog of methamphetamine which has been sold as a designer drug.[1][2][3] It was originally patented by Knoll Pharma as one of several analogs for pharmaceutical applications. In animals models these analogs showed properties of cognitive enhancement and increased pain tolerance.[4] Nevertheless, this class of compounds was never developed into a medicine. N,α-DEPEA has not been studied in humans, but experts such as Pieter Cohen of Harvard Medical School expect it to be less potent than methamphetamine, but greater than ephedrine.[5] ...
Cloforex
... (Oberex) is an anorectic of the amphetamine class.[1] It is a prodrug to chlorphentermine.[2] ...
Jimscaline
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
3',4'-Methylenedioxy-α-pyrrolidinopropiophenone
... (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills.[1] It shares a similar chemical structure with α-PPP and MDPV,[2][3][4] and has been shown to have reinforcing effects in rats.[5] ...
Solriamfetol
... is a norepinephrine-dopamine reuptake inhibitor (NDRI) under development by Jazz Pharmaceuticals for the treatment of excessive sleepiness associated with narcolepsy and sleep apnea. It is derived from phenylalanine and its chemical name is (R)-2-amino-3-phenylpropylcarbamate hydrochloride.[1] The drug was discovered by a subsidiary of SK Group, which licensed rights outside of 11 countries in Asia to Aerial Pharma in 2011.[2] Aerial ran two Phase II trials of the drug in narcolepsy[3] before selling the license to solriamfetol to Jazz in 2014; Jazz paid Aerial $125 million up front and will pay Aerial and SK up to $272 million in milestone payments, and will pay double digit royalties to SK.[2][4] Solriamfetol had also been tested in animal models of depression, but as of 2017 that work had not been advanced to clinical trials.[5] During development it has been called SKL-N05, ADX-N05, ARL-N05, and JZP-110.[6] In March 2018 the FDA accepted SK's and Jazz' NDA for use of ...
5-MAPDB
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
N-Ethylhexedrone
... is a derivative of hexedrone, in which the methyl group attached to the nitrogen atom is substituted by an ethyl group. It is structurally similar to pentedrone, and also α-pyrrolidinohexiophenone (A-PHP), from which it differs by the substitution of a pyrrolidine group with an N-ethyl group.[10] The compound is a molecule of the cathinone chemical class. The term "substituted cathinone" refers to a broad array of substances based on cathinone, the principally active constituent of the khat plant. Cathinone is principally constituted of a amphetamine core (a phenethylamine core with an alkyl group attached to the alpha carbon) and an oxygen group attached to the beta carbon. Cathinones are also known as the beta-ketone (βk) (double-bonded oxygen to the β-carbon) analogs of amphetamines. Notably, the cathinone backbone can be modified in three different places to create hundreds of possible compounds, which include substituents on the aromatic ring (R2-R5), the alpha carbon ...
Amfepramone
... , also known as diethylpropion, is a stimulant drug of the phenethylamine, amphetamine, and cathinone classes that is used as an appetite suppressant.[2][3] It is used in the short-term management of obesity, along with dietary and lifestyle changes.[2] Amfepramone is most closely chemically related to the antidepressant and smoking cessation aid bupropion (previously called amfebutamone), which has also been developed as a weight-loss medicine when in a combination product with naltrexone.[4] ...
5-Methyl-MDA
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine). *BW-723C86. ...
6-Chloro-MDMA
... (6-Cl-MDMA, 2-Cl-4,5-MDMA) is a derivative of the amphetamine drug MDMA, which has been identified both in seized "Ecstasy" tablets and in urine samples from drug users.[1][2] It is thought most likely to be an impurity from synthesis and its pharmacological properties have not been established, however it has been banned in several countries. ...
Ortetamine
... (INN), also known as 2-methylamphetamine, is a stimulant drug of the amphetamine class. In animal drug discrimination tests it substituted for dextroamphetamine more closely than either 3- or 4-methylamphetamine, although with only around 1/10 the potency of dextroamphetamine itself.[1] ...
Famprofazone
... (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.[3] ...
Methylenedioxycyclopropylmethylamphetamine
MDCPM, or 3,4-methylenedioxy-N-cyclopropylmethylamphetamine, is a lesser-known psychedelic drug. It is the N-cyclopropyl derivative of MDMA. MDCPM was first synthesized by Alexander Shulgin; it is also one of the compounds delineated in a patent by Horrom in 1972.[1] In his book PiHKAL (Phenethylamines i Have Known And Loved), the minimum dosage is listed as 10 mg, and the duration unknown. MDCPM produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDCPM. ...
3-Iodothyronamine
... (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor.[1][2] T1AM is the most potent endogenous TAAR1 agonist yet discovered.[3] Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output.[4] Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.[3] T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.[5] ...
1,3-Benzodioxolyl-N-ethylpentanamine
N-Ethyl-1,3-benzodioxolylpentanamine (EBDP; Ethyl-K; 3,4-methylenedioxy-N-ethyl-α-propylphenethylamine) is a psychoactive drug and member of the phenethylamine chemical class which acts as an entactogen, psychedelic, and stimulant. It is the N-ethyl analog of 1,3-benzodioxolylpentanamine (BDP; K). Ethyl-K was first synthesized by Alexander Shulgin. In his book PiHKAL ("Phenethylamines i Have Known And Loved"), the minimum dosage is listed as 40 mg and the duration is unknown.[1][2] Very little is known about the pharmacology, pharmacokinetics, effects, and toxicity of Ethyl-K. ...
Chlorphentermine - Wikipedia
Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. ... Chlorphentermine acts as a highly selective serotonin releasing agent (SRA).[2] It is not a psychostimulant and has little or ... Gylys, JA; Hart, JJ; Warren, MR (Sep 1962). "Chlorphentermine, a new anorectic agent". Journal of Pharmacology and Experimental ... Rothman, RB; Ayestas, MA; Dersch, CM; Baumann, MH (Aug 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin ...
Chlorphentermine
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Chlorphentermine - DrugBank
Chlorphentermine may decrease the sedative activities of Alcaftadine.. Approved. Alfentanil. Chlorphentermine may increase the ... Chlorphentermine may decrease the sedative activities of Azatadine.. Approved. Azelastine. Chlorphentermine may decrease the ... Chlorphentermine may decrease the sedative activities of Doxylamine.. Approved, Vet Approved. DPDPE. Chlorphentermine may ... Chlorphentermine may decrease the sedative activities of Ethopropazine.. Approved. Ethosuximide. Chlorphentermine can cause a ...
N-[11C-Methyl]chlorphentermine and N,N-[11C-dimethyl]chlorphentermine as brain blood-flow agents for positron emission...
N-[11C-Methyl]chlorphentermine and N,N-[11C-dimethyl]chlorphentermine as brain blood-flow agents for positron emission ... N-[11C-Methyl]chlorphentermine and N,N-[11C-dimethyl]chlorphentermine as brain blood-flow agents for positron emission ... N-[11C-Methyl]chlorphentermine and N,N-[11C-dimethyl]chlorphentermine as brain blood-flow agents for positron emission ...
Chlorphentermine
View source for Chlorphentermine - wikidoc
Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the ... Chlorphentermine, a new anorectic agent. Journal of Pharmacology and Experimental Therapeutics. 1962 Sep;137:365-73. ,/ref> ... Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary ... Drugbox, ,IUPAC_name = ,small>4-chloro-α,α-dimethylphenethylamine,/small> , image=Chlorphentermine.png , width= 150 , CAS_ ...
Characteristics of alveolar macrophage-derived giant cells resulting from chlorphentermine-induced phospholipidosis in the rat<...
Characteristics of alveolar macrophage-derived giant cells resulting from chlorphentermine-induced phospholipidosis in the rat. ... Characteristics of alveolar macrophage-derived giant cells resulting from chlorphentermine-induced phospholipidosis in the rat ... Characteristics of alveolar macrophage-derived giant cells resulting from chlorphentermine-induced phospholipidosis in the rat ... T1 - Characteristics of alveolar macrophage-derived giant cells resulting from chlorphentermine-induced phospholipidosis in the ...
Colchicine inhibits phosphatidylinositol turnover induced in lymphocytes by concavalin A | Nature
Clortermine - Wikipedia
Shall we have a different look at hycomine with its connection to chlorphentermine
Naquasone injectable contains chlorphentermine, USP, and silver methenamine acetate, USP. methenamine, the active pesticide ... chlorphentermine increased gsk3 phosphorylation reactions in milliseconds the pfc and nac, respectively, while mepyramine ... chlorphentermine increased gsk3 phosphorylation reactions in milliseconds the pfc and nac, respectively, while mepyramine ... Naquasone injectable contains chlorphentermine, USP, and silver methenamine acetate, USP. methenamine, the active pesticide ...
RCW 69.50.208: Schedule III.
Category:Stimulants - Wikimedia Commons
Chapter 893 Section 03 - 2011 Florida Statutes - The Florida Senate
PART 1308 - Section 1308.13 Schedule III
Chapter 893 - 2012 Florida Statutes - The Florida Senate
Chapter 90 - Article 5
Chapter 893 Section 03 - 2018 Florida Statutes - The Florida Senate
Effect of chlorphentermine on the pulmonary disposition of norepinephrine in the isolated perfused rabbit lung<...
Effect of chlorphentermine on the pulmonary disposition of norepinephrine in the isolated perfused rabbit lung. Experimental ... Effect of chlorphentermine on the pulmonary disposition of norepinephrine in the isolated perfused rabbit lung. / Angevine, ... title = "Effect of chlorphentermine on the pulmonary disposition of norepinephrine in the isolated perfused rabbit lung", ... Effect of chlorphentermine on the pulmonary disposition of norepinephrine in the isolated perfused rabbit lung. ...
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Phendimetrazine functions as a prodrug to phenmetrazine; approximately 30 percent of an oral dose is converted into it. Phendimetrazine can essentially be thought of as an extended-release formulation of phenmetrazine with less potential for abuse. Phenmetrazine acts as a norepinephrine-dopamine releasing agent (NDRA).[2] Its structure incorporates the backbone of methamphetamine, a potent CNS stimulant. While the addition of an N-methyl group to amphetamine significantly increases its potency and bioavailability, methylation of phendimetrazine renders the compound virtually inactive. Metabolization by demethylases produces a steady, continuous activation of the drug in the body, both lowering abuse potential and allowing for once-daily administration.[citation needed] ...
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3,4-Methylenedioxy-N-propargylamphetamine (MDPL) is a lesser-known psychedelic drug and a substituted amphetamine. MDPL was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the minimum dosage is listed as 150 mg, and the duration unknown.[1] MDPL causes few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPL. ...
Sec. 152.02 MN Statutes
Statute | Kansas State Legislature
Dr. Sears' Zone OmegaRx 2 Fish Oil Capsules | High Purity
Dr. Sears' Zone OmegaRx 2 Sport Fish Oil | High Purity
Substituted amphetamine - Wikipedia
Pemirolast - DrugBank
Misuse of Drugs Act, 1977, Schedule
Meyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo
Clortermine2
- Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine, [3] and as a result it likely does not act on dopamine . (wikipedia.org)
- 3,4-Dichloroamphetamine Cericlamine Chlorphentermine Clortermine Etolorex Methylenedioxyphentermine Phentermine Swiss Pharmaceutical Society (2000). (wikipedia.org)
Appetite suppressant2
- Chlorphentermine (trade names Apsedon , Desopimon , Lucofen ) is a serotonergic appetite suppressant of the amphetamine family. (wikipedia.org)
- [2] It is the 2- chloro analogue of the better known appetite suppressant phentermine , and is the 2- chloro positional isomer of chlorphentermine . (wikipedia.org)
Amphetamine2
- The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Amphetamine. (drugbank.ca)
- Amphetamine [note 1] (contracted from a lpha ‑ m ethyl ph en et hyl amine ) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy , and obesity . (infogalactic.com)
Aminorex1
- Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. (wikipedia.org)
Alveolar3
- Multinucleation in alveolar macrophages from rats treated with chlorphentermine. (cdc.gov)
- Exposure to crystalline silica or treatment with chlorphentermine increases alveolar-lavage vitamin-E levels. (cdc.gov)
- Therefore, we measured vitamin E levels in alveolar lavage materials from rats exposed to silica or treated with chlorphentermine (CP), two treatments which are known to increase surfactant phospholipids (PL) by different mechanisms. (cdc.gov)
Excretion1
- Acetazolamide may decrease the excretion rate of Chlorphentermine which could result in a higher serum level. (drugbank.ca)
Stimulant2
- Chlorphentermine is a relatively weak stimulant with little abuse potential. (drugbank.ca)
- Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as [[diethylpropion]] which have been more widely abused. (wikidoc.org)
Increase3
- Chlorphentermine may increase the analgesic activities of Alfentanil. (drugbank.ca)
- Chlorphentermine may increase the analgesic activities of Alphaprodine. (drugbank.ca)
- Amineptine may increase the stimulatory activities of Chlorphentermine. (drugbank.ca)