Chlorphentermine: A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.Aminorex: An amphetamine-like anorectic agent. It may cause pulmonary hypertension.Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.Methenamine: An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)Phenazopyridine: A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.Pneumocystis: A genus of ascomycetous FUNGI, family Pneumocystidaceae, order Pneumocystidales. It includes various host-specific species causing PNEUMOCYSTIS PNEUMONIA in humans and other MAMMALS.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.Oenothera: A plant genus of the family ONAGRACEAE. Members contain oenotheins.Viola: A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.Depression, Chemical: The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.United States Department of Agriculture: A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.North CarolinaResearch Subjects: Persons who are enrolled in research studies or who are otherwise the subjects of research.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Methyltestosterone: A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).United States Department of Homeland Security: A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to domestic national security.FloridaMethane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)State Government: The level of governmental organization and function below that of the national or country-wide government.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Judicial Role: The kind of action or activity proper to the judiciary, particularly its responsibility for decision making.History of MedicineMinors: A person who has not attained the age at which full civil rights are accorded.Athletic Performance: Carrying out of specific physical routines or procedures by one who is trained or skilled in physical activity. Performance is influenced by a combination of physiological, psychological, and socio-cultural factors.Great Lakes Region: The geographic area of the Great Lakes in general and when the specific state or states are not indicated. It usually includes Illinois, Indiana, Michigan, Minnesota, New York, Ohio, Pennsylvania, and Wisconsin.Eicosapentaenoic Acid: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.Fishes: A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.Hindlimb Suspension: Technique for limiting use, activity, or movement by immobilizing or restraining animal by suspending from hindlimbs or tails. This immobilization is used to simulate some effects of reduced gravity and study weightlessness physiology.Doping in Sports: Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.Sports Medicine: The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.Secobarbital: A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.KansasAmobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Barbiturates: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.Conjunctivitis, Allergic: Conjunctivitis due to hypersensitivity to various allergens.Surgery, Veterinary: A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)PyrimidinonesAnti-Allergic Agents: Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.Histamine Release: The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Audiovisual Aids: Auditory and visual instructional materials.FinlandCognitive Science: The study of the precise nature of different mental tasks and the operations of the brain that enable them to be performed, engaging branches of psychology, computer science, philosophy, and linguistics. (Random House Unabridged Dictionary, 2d ed)Computer-Assisted Instruction: A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (1/6)

BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders.  (+info)

The metabolism, distribution and elimination of chlorphentermine in man. (2/6)

1 A gas-liquid chromatography procedure for the determination of chlorphentermine (I), N-hydroxychlorphentermine (II) and alpha,alpha-dimethyl-alpha-nitro-beta-(4-chlorophenyl)ethane (IV) in urine has been developed. Also methods are reported to determine conjugated II and the total N-oxidized metabolites of I, i.e. II, conjugated II, alpha,alpha-dimethyl-alpha-nitroso-beta-(4-chlorophenyl)ethane (III) and IV in urine. 2 The synthesis of alpha,alpha-dimethyl-alpha-nitroso-beta-(4-chlorophenyl)ethane (III) and its properties are reported. 3 The kinetics of urinary excretion of I and its metabolic products after the oral administration of I to a human subject on separate occasions have been studied. Under normal conditions of urinary pH, metabolism by N-oxidation was the main elimination route of I; acidifying the urine increased the urinary excretion of unchanged I at the expense of the N-oxidized products. 4 The importance of the N-oxidation metabolic route in the distribution of chlorphentermine (I) in man is discussed.  (+info)

N-[11C-Methyl]chlorphentermine and N,N-[11C-dimethyl]chlorphentermine as brain blood-flow agents for positron emission tomography. (3/6)

N-[11C-methyl]chlorphentermine ([11C]NMCP) and N,N-[11C-dimethyl]chlorphentermine ([11C]NDMCP) were prepared from chlorphentermine and 11CH3I in DMF and evaluated in rats as brain blood-flow agents for positron emission tomography (PET). Tissue distribution of [11C]NMCP showed that brain uptake was 2.70 +/- 0.40% of injected dose per organ at 5 min with no change in radioactivity concentration up to 30 min after i.v. injection. Approximately 80% of the initial brain uptake remained at 60 min. On the other hand, initial brain uptake of [11C] NDMCP (3.66 +/- 0.31 and 3.63 +/- 0.88% injected dose per organ at 5 and 15 min, respectively) was greater than that of [11C]NMCP. The brain activity however, rapidly decreased to 2.38 +/- 0.17 and 1.82 +/- 0.32% at 30 and 60 min, respectively. Because of its longer retention in the brain compared with [11C]NDMCP, [11C]NMCP would be a potential brain blood-flow agent for quantitative PET studies.  (+info)

Fluorescence studies of the binding of amphiphilic amines with phospholipids. (4/6)

The binding characteristics of several amine drugs with dispersed phospholipids (phosphatidylcholine, phosphatidylserine, and phosphatidylglycerol) have been studied using the fluorometric method and 1-anilino-8-naphthalene sulfonate and 1,6 diphenyl-1,3,5-hexatriene as fluorescence probes. The results show that amphiphilic amines, such as chlorphentermine, interact with phospholipids via both ionic and hydrophobic forces. The ionic interaction, which occurs between the protonated amine group of the drug and the phosphate oxygen of the lipid, changes the amphiphilic characteristics of the lipid by reducing the number of negative charges on the lipid vesicles, and inhibits the Ca2+-dependent lipid hydrolysis by blocking the Ca2+ binding sites on the lipid vesicles. The hydrophobic interaction, which involves the nonpolar moieties of the drug and the lipid, is of primary importance to the overall drug-lipid binding stability. Drugs without a strong hydrophobic moiety, such as dopamine, do not interact with phospholipids.  (+info)

Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats. (5/6)

1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion).2 There was very little difference between the potencies of (+)- and (-)-amphetamine.3p-Chloromethamphetamine was a more potent aversive agent than methamphetamine.4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine.5 Cocaine induced only moderate taste aversions, even at high doses.6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.  (+info)

Effect of chlorphentermine on the lipids of rat lungs. (6/6)

Chronic administration of chlorphentermine to rats resulted in a reduction of body weight compared to a normal control group. The weight of the heart, liver, kidney, and spleen was less in the treated group while the weight of the lungs was increased significantly. There was no change in the ratio of right ventricular to left ventricular weight in the rats treated with chlorphentermine, supporting the views that this drug does not cause pulmonary hypertension. Biochemical analysis showed that the increase in the weight of the lungs was due to the accumulation of phospholipid. All classes of phospholipid were affected, but particularly phosphatidyl choline, the tissue concentration of which increased nine times. Chlorphentermine also increased the proportion of palmitate present in pulmonary phosphatidyl choline. Histological examination of the lung after treatment with chlorphentermine showed evidence of this drug-induced lipidosis. No conclusion can as yet be reached as to the mechanism involved in the accumulation of phospholipid in the lung after chlorphentermine.  (+info)

*Chlorphentermine

... acts as a highly selective serotonin releasing agent (SRA). It is not a psychostimulant and has little or no ... Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. ... Rothman, RB; Ayestas, MA; Dersch, CM; Baumann, MH (Aug 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin ... "Chlorphentermine, a new anorectic agent". Journal of Pharmacology and Experimental Therapeutics. 137: 365-73. Rothman RB, ...

*Cloforex

It is a prodrug to chlorphentermine. 3,4-Dichloroamphetamine Cericlamine Chlorphentermine Clortermine Etolorex ...

*Phentermine

Cericlamine Chlorphentermine Cloforex Clortermine Etolorex Methylenedioxyphentermine "METERMINE (Phentermine)" (PDF). TGA ...

*Etolorex

3,4-Dichloroamphetamine Cericlamine Chlorphentermine Cloforex Clortermine Methylenedioxyphentermine Phentermine David J. ...

*C10H14ClN

The molecular formula C10H14ClN may refer to: para-Chloromethamphetamine Chlorphentermine Clortermine N-Ethyl-N-(2-chloroethyl) ...

*Serotonin releasing agent

Chlorphentermine (Apsedon, Desopimon, Lucofen) Cloforex (Oberex) (prodrug of chlorphentermine) Dexfenfluramine (Redux) ( ... Fenfluramine, chlorphentermine, and aminorex, which are also amphetamines and relatives, were formerly used as appetite ... related to chlorphentermine; never marketed) Indeloxazine (Elen, Noin) (non-selective; discontinued) Levofenfluramine ( ... enantiomer of fenfluramine) Etolorex (prodrug of chlorphentermine; never marketed) Fenfluramine (Pondimin, Fen-Phen) Flucetorex ...

*3,4-Methylenedioxyphentermine

3,4-Dichloroamphetamine Cericlamine Chlorphentermine Cloforex Clortermine Etolorex Phentermine MDPH entry in PiHKAL "UK Misuse ...

*Clortermine

... produces very low rates of self-administration in animals similarly to chlorphentermine, and as a result it likely ... 4-Dichloroamphetamine Cericlamine Chlorphentermine Cloforex Etolorex Methylenedioxyphentermine Phentermine US patent 3415937, " ... and is the 2-chloro positional isomer of chlorphentermine. ...

*3,4-Dichloroamphetamine

3-Methoxy-4-methylamphetamine Cericlamine Chlorphentermine Clortermine Etolorex 3,4-Methylenedioxyamphetamine ...

*Cericlamine

3,4-Dichloroamphetamine Alaproclate Bupropion Chlorphentermine Clortermine Cloforex Etolorex Femoxetine Ifoxetine Indalpine ... and closely related to chlorphentermine, a highly selective serotonin releasing agent) that was investigated as an ...

*2-Nitropropane

... has uses in the synthesis of phentermine, chlorphentermine, as well as in the synthesis of teclozan, etc. 2- ...

*5-HT2B receptor

MDMA (Ecstasy) MDA MEM Pergolide Cabergoline Norfenfluramine Chlorphentermine Aminorex mCPP Bromo-dragonfly DMT 5-MeO-DMT LSD- ...

*Controlled Drugs and Substances Act

Chlorphentermine (1-(p-chlorophenyl)-2-methyl-2-aminopropane) and any salt thereof Diethylpropion (2-(diethylamino) ...

*Misuse of Drugs Act (Ireland)

Chlorphentermine Diethylpropion Ethchlorvnol (presumably Ethchlorvynol) Ethinamate Flunitrazepam (moved up from Schedule 4 by ...

*Misuse of Drugs Act (Singapore)

Benzphetamine Chlorphentermine Flunitrazepam (Rohypnol) Flutoprazepam (Restas) Mephentermine Pipradrol Triazolam (Halcion) For ...

*Serotonin

... chlorphentermine, and aminorex), and certain anti-Parkinsonian dopaminergic agonists, which also stimulate serotonergic 5-HT2B ...

*Cardiac fibrosis

The drugs most classically associated with the condition are weight loss drugs such as fenfluramine and chlorphentermine, and ... chlorphentermine, and aminorex (along with its analogue 4-Methylaminorex which has seen sporadic use as a recreational drug) ...

*List of MeSH codes (D02)

... chlorphentermine MeSH D02.092.471.683.152.766.617 --- mephentermine MeSH D02.092.471.683.221 --- butoxamine MeSH D02.092. ...

*List of drugs: Cf-Ch

... chlorphentermine (INN) chlorproethazine (INN) chlorproguanil (INN) chlorpromazine (INN) chlorpropamide (INN) chlorprothixene ( ...
chlorphentermine increased gsk3 phosphorylation reactions in milliseconds the pfc and nac, respectively, while mepyramine elevated it in bumping the nac only. Naquasone injectable contains chlorphentermine, USP, and silver methenamine acetate, USP. methenamine, the active pesticide ingredient than in Uralgic, is also approved activities as an ideal antihypertensive. Analytical analysis scores of the urine samples showed that methenamine was excreted unchanged as the intact complex indicating precisely the absence r
1-(4-Methylphenyl)-2-aminobutane • 2-Fluoroamphetamine • 2-Fluoromethamphetamine • 2-OH-PEA • 2-Phenyl-3-aminobutane • 2-Phenyl-3-methylaminobutane • 2,3-MDA • 3-Fluoroamphetamine • 3-Fluoroethamphetamine • 3-Fluoromethcathinone • 3-Methoxyamphetamine • 3-Methylamphetamine • 4-BMC • 4-Ethylamphetamine • 4-FA • 4-FMA • 4-MA • 4-MMA • 4-MTA • 6-FNE • Alfetamine • α-Ethylphenethylamine • Amfecloral • Amfepentorex • Amfepramone • Amidephrine • Amfetamini (Dextroamphetamine, Levoamphetamine) • Amphetaminil • Arbutamine • β-Methylphenethylamine • β-Phenylmethamphetamine • Benfluorex • Benzphetamine • BDB (J) • BOH (Hydroxy-J) • BPAP • Buphedrone • Bupropion (Amfebutamone) • Butylone • Cathine • Cathinone • Chlorphentermine • Cinnamedrine • Clenbuterol • Clobenzorex • Cloforex • Clortermine • D-Deprenyl • Denopamine • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone (Dimethylpropion, ...
Pressure mine: The pressure mine employs the principle that beneath every ship in motion in shallow water there is an area of reduced pressure. The pressure mine contains a chamber divided by a diaphragm, with one side of the chamber open to the sea. Any sudden decrease in…
Aminoindanes: 5-Iodoaminoindane (5-IAI) • Ethyltrifluoromethylaminoindane (ETAI) • Methylenedioxyaminoindane (MDAI) • Methylenedioxymethylaminoindane (MDMAI) • Methoxymethylaminoindane (MMAI) • Trifluoromethylaminoindane (TAI); Aminotetralins: 6-Chloroaminotetralin (6-CAT) • 8-Hydroxydipropylaminotetralin (8-OH-DPAT) • Methylenedioxyaminotetralin (MDAT); Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX) • Aminorex • Clominorex • Fluminorex; Phenethylamines (also Amphetamines, Cathinones, Phentermines, etc): 4-Methylthioamphetamine (4-MTA) • Benzodioxolylbutanamine (BDB) • Benzodioxolylhydroxybutanamine (BOH) • Brephedrone • Butylone • Chlorphentermine • Diethylcathinone (Diethylpropion, Amfepramone) • Dimethoxyamphetamine (DMA) • Dimethoxymethamphetamine (DMMA) • Dimethylcathinone (Dimethylpropion, Metamfepramone) • Ethylbenzodioxolylbutanamine (EBDB) • Ethylone • Fenfluramine (Dexfenfluramine) • Flephedrone • Lophophine (Homomyristicylamine) • ...
Aminoindanes: 5-Iodoaminoindane (5-IAI) • Ethyltrifluoromethylaminoindane (ETAI) • Methylenedioxyaminoindane (MDAI) • Methylenedioxymethylaminoindane (MDMAI) • Methoxymethylaminoindane (MMAI) • Trifluoromethylaminoindane (TAI); Aminotetralins: 6-Chloroaminotetralin (6-CAT) • 8-Hydroxydipropylaminotetralin (8-OH-DPAT) • Methylenedioxyaminotetralin (MDAT); Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX) • Aminorex • Clominorex • Fluminorex; Phenethylamines (also Amphetamines, Cathinones, Phentermines, etc): 4-Methylthioamphetamine (4-MTA) • Benzodioxolylbutanamine (BDB) • Benzodioxolylhydroxybutanamine (BOH) • Brephedrone • Butylone • Chlorphentermine • Diethylcathinone (Diethylpropion, Amfepramone) • Dimethoxyamphetamine (DMA) • Dimethoxymethamphetamine (DMMA) • Dimethylcathinone (Dimethylpropion, Metamfepramone) • Ethylbenzodioxolylbutanamine (EBDB) • Ethylone • Fenfluramine (Dexfenfluramine) • Flephedrone • Lophophine (Homomyristicylamine) • ...
putative ABC transporter substrate binding protein [lipoprotein] ATGCGTTCTCGTGTGTGGTGGGGTACGACGGCCGCGGTGCTGGGTGGCCTCCTCGTGGCG GGCTGTGGTGACGGAGGCGGCAGTGGCGGCGGTGACAAGGCGGGCCCCGCCGACGAGAAG TCGGCCACCGGCCACTACCCGGTCACCGTCACCGATTGCATGGACGCCAAGACCACGTTC TCCAAGGCCCCCGAGAAGATCGTCACCAGCAACGCCTCCAGCCTGGAACTGCTGCTGCGC CTCGGCGCCGGTGACAACGTCATCGGCACCGGCTTCCCGCCCGGCAAGGGAACGCTGCCC GGTGAACTCGACGCGCAGGCGCGGAAGGTGAAGGCGCTCGGGCAGTCCGTGATCCCGAAG GAGAAGCTCCTCGGCTCCGGCGCGGATCTGTACATCGACACCTTCGCCTCGATGAACATG GGCGGCGGCATGGGCGACGCGCCGACCGAGGAGGAGTTCAAGGCGGCCGGAATCAAGCAC ATCTACCTCAAGTCCACCGCCTGTGCGGCGCGGAACAAGGGCGCGGTGACCGACCTGTCC GCGGTGGAGGCCGACATCACCTCCCTCGGCGCGGTCACTGGCACCAGCGCGAAGGCGAAG GAACTCGTCGACGGCATGAAGGGGAAGCTGGACGCCGTCCGGAAGGCGGTCGGCCGGACG GCGGAGGGCGAGCGGCCGACGTACTTCTTCTTCGACTACGACGCCGGCACCAAGCAGCCC ACCGTCGTCTGCAACCGCCAGGTCGCCAACGCGGTGATCACTCTGGCCGGTGCCCGCAAT GTCTTCGCCGACTGCGACGGCGACTACAAGCAGGTCGGCTGGGAGGACGTCATTTCCCGG AACCCGGACTGGATCCAGTTGGGCGTCCGCGATCGGGGCAGCGAGGCGGCGAACCAGAAG ...
Ornim, maker of a noninvasive patient blood flow monitoring system, closed an initial $20 million Series C round. The funding will help the company commercialize its product in Asia, as well as in the U.S.
... works with the bodys natural resources to reduce pain & inflammation. The unique combination of ingredients stimulate blood-flow to rapidly repair damaged, irritated skin conditions while simultaneously fighting bacterial viral & fungal infections
From Admin: The article reports a novel optical Blood-flow sensor used for measuring velocity of blood flow below skin, which is based on the principle of Droppler shift. The sensor is an integrated module with laser diode and photodiode [more...] ...
Beginning in midlife, heart disease leads to subtle blood-flow problems in the brain that develop insidiously, gradually damaging neurons and contributing to cognitive decline. Knowledge of clinically silent blood-flow problems in the brain has led to the “healthy heart, healthy mind” hypothesis that preventing or treating heart disease also may help prevent age-associated cognitive decline.

Chlorphentermine - WikipediaChlorphentermine - Wikipedia

Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. ... Chlorphentermine acts as a highly selective serotonin releasing agent (SRA).[2] It is not a psychostimulant and has little or ... Gylys, JA; Hart, JJ; Warren, MR (Sep 1962). "Chlorphentermine, a new anorectic agent". Journal of Pharmacology and Experimental ... Rothman, RB; Ayestas, MA; Dersch, CM; Baumann, MH (Aug 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin ...
more infohttps://en.wikipedia.org/wiki/Chlorphentermine

ChlorphentermineChlorphentermine

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttp://webbook.nist.gov/cgi/inchi/InChI%3D1S/C10H14ClN/c1-10

Chlorphentermine - DrugBankChlorphentermine - DrugBank

Chlorphentermine may decrease the sedative activities of Alcaftadine.. Approved. Alfentanil. Chlorphentermine may increase the ... Chlorphentermine may decrease the sedative activities of Azatadine.. Approved. Azelastine. Chlorphentermine may decrease the ... Chlorphentermine may decrease the sedative activities of Doxylamine.. Approved, Vet Approved. DPDPE. Chlorphentermine may ... Chlorphentermine may decrease the sedative activities of Ethopropazine.. Approved. Ethosuximide. Chlorphentermine can cause a ...
more infohttps://www.drugbank.ca/drugs/DB01556

Shall we have a different look at hycomine with its connection to chlorphentermineShall we have a different look at hycomine with its connection to chlorphentermine

Naquasone injectable contains chlorphentermine, USP, and silver methenamine acetate, USP. methenamine, the active pesticide ... chlorphentermine increased gsk3 phosphorylation reactions in milliseconds the pfc and nac, respectively, while mepyramine ... chlorphentermine increased gsk3 phosphorylation reactions in milliseconds the pfc and nac, respectively, while mepyramine ... Naquasone injectable contains chlorphentermine, USP, and silver methenamine acetate, USP. methenamine, the active pesticide ...
more infohttp://pureglassbottle.com/pharm-news/akorn-inc-et-al-v-lupin-atlantis-holdings-sa-et-al.html

Clortermine - WikipediaClortermine - Wikipedia

Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it ...
more infohttps://en.wikipedia.org/wiki/Clortermine

RCW 69.50.208: Schedule III.RCW 69.50.208: Schedule III.

3) Chlorphentermine;. (4) Clortermine;. (5) Phendimetrazine.. (b) Depressants. Unless specifically excepted or unless listed in ...
more infohttp://apps.leg.wa.gov/RCW/default.aspx?cite=69.50.208

PART 1308 - Section 1308.13 Schedule IIIPART 1308 - Section 1308.13 Schedule III

3) Chlorphentermine. 1645 (4) Clortermine. 1647 (5) Phendimetrazine. 1615 (c) Depressants. Unless specifically excepted or ...
more infohttps://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_13.htm

Chapter 90 - Article 5Chapter 90 - Article 5

2. Chlorphentermine.. 3. Clortermine.. 4. Repealed by Session Laws 1987, c. 412, s. 10. ...
more infohttps://www.ncleg.net/EnactedLegislation/Statutes/HTML/ByArticle/Chapter_90/Article_5.html

Chapter 893 Section 03 - 2013 Florida Statutes - The Florida SenateChapter 893 Section 03 - 2013 Florida Statutes - The Florida Senate

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Chapter 893 Section 03 - 2016 Florida Statutes - The Florida SenateChapter 893 Section 03 - 2016 Florida Statutes - The Florida Senate

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Chapter 893 Section 03 - 2018 Florida Statutes - The Florida SenateChapter 893 Section 03 - 2018 Florida Statutes - The Florida Senate

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Phendimetrazine functions as a prodrug to phenmetrazine; approximately 30 percent of an oral dose is converted into it. Phendimetrazine can essentially be thought of as an extended-release formulation of phenmetrazine with less potential for abuse. Phenmetrazine acts as a norepinephrine-dopamine releasing agent (NDRA).[2] Its structure incorporates the backbone of methamphetamine, a potent CNS stimulant. While the addition of an N-methyl group to amphetamine significantly increases its potency and bioavailability, methylation of phendimetrazine renders the compound virtually inactive. Metabolization by demethylases produces a steady, continuous activation of the drug in the body, both lowering abuse potential and allowing for once-daily administration.[citation needed] ...
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3,4-Methylenedioxy-N-propargylamphetamine (MDPL) is a lesser-known psychedelic drug and a substituted amphetamine. MDPL was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the minimum dosage is listed as 150 mg, and the duration unknown.[1] MDPL causes few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPL. ...
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Category:Stimulants - Wikimedia CommonsCategory:Stimulants - Wikimedia Commons

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Substituted amphetamine - WikipediaSubstituted amphetamine - Wikipedia

Chlorphentermine. 4-Chloro-α-methylamphetamine. 2 para-Fluoromethamphetamine (PFMA, 4-FMA). 4-Fluoro-N-methylamphetamine. 2 ...
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Chlorphentermine. Chlorphentermine may decrease the sedative activities of Pemirolast.. Illicit, Withdrawn. Dextroamphetamine. ...
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  • Acetazolamide may decrease the excretion rate of Chlorphentermine which could result in a higher serum level. (drugbank.ca)