Chlorpheniramine
Histamine H1 Antagonists
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Receptors, Histamine H1
A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Dimethindene
Histamine Antagonists
Triprolidine
Histamine
Receptors, Histamine H2
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Dimaprit
Receptors, Histamine
Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.
Burimamide
Histamine H2 Antagonists
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Hydroxyzine
Clemastine
Ketotifen
Cimetidine
Methylhistamines
Histamine Agonists
Pyrilamine
Diphenhydramine
Impromidine
Stereoisomerism
Hydrocodone
Intestinal Obstruction
Biliary Tract Diseases
Gastric Outlet Obstruction
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system. (1/137)
Transport characteristics of diphenhydramine, an antihistamine, were studied in cultured human intestinal Caco-2 cell monolayers to elucidate the mechanisms of its intestinal absorption. Diphenhydramine accumulation in the monolayers increased rapidly and was influenced by extracellular pH (pH 7.4 > 6.5 > 5.5). Diphenhydramine uptake was temperature dependent, saturable, and not potential sensitive. Kinetic analysis revealed that the apparent Km values were constant (0.8-1.0 mM) in all pH conditions tested, whereas Vmax values decreased at the lower pH. The initial uptake of diphenhydramine was competitively inhibited by another antihistamine, chlorpheniramine, with a Ki value of 1.3 mM. On the other hand, cimetidine and tetraethylammonium, typical substrates for the renal organic cation transport system, had no effect. Moreover, biological amines and neurotransmitters, such as histamine, dopamine, serotonin, and choline, also had no effect on the diphenhydramine accumulation. Finally, diphenhydramine uptake was stimulated by preloading monolayers with chlorpheniramine (trans-stimulation effect). These findings indicate that diphenhydramine transport in Caco-2 cells is mediated by a specific transport system. This pH-dependent transport system may contribute to the intestinal absorption of diphenhydramine. (+info)Nalpha-methyl histamine and histamine stimulate gastrin release from rabbit G-cells via histamine H2-receptors. (2/137)
BACKGROUND: Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin release. H. pylori is reported to produce Nalpha-methyl histamine (NalphaMH), which is an agonist of H3 as well as other histamine receptors. H. pylori infection also recruits mast cells, which release histamine. AIM: To determine the direct effects of histamine receptor agonists on isolated gastrin cells. METHODS: Rabbit G-cells were prepared by countercurrent elutriation and cultured on 24-well plates. RESULTS: NalphaMH (10-6-10-4 M) caused a dose-dependent increase in gastrin release from a basal level of 2.3 +/- 0.2% total cell content (TCC; mean +/- S.E.M.) to a maximum of 5.1 +/- 0.7%, an increase of 117% (P < 0. 005) above basal. This was abolished by the H2-antagonist ranitidine (10-5 M), but not by immunoblockade with anti-somatostatin antibody, the H1-antagonist chlorpheniramine (10-5 M) or the H3-antagonist thioperamide (10-4 M). The histamine H2-receptor agonist dimaprit (10-6-10-4 M) increased gastrin release from 2.4 +/- 0.2% to 3.6 +/- 0.2% TCC (P < 0.001). Gastrin release was also stimulated by histamine (10-7-10-4 M) from a basal value of 3.0 +/- 0.3% to 5.4 +/- 0.5% TCC (P < 0.001). This also was inhibited by ranitidine (10-5 M) (P < 0.01). CONCLUSION: NalphaMH and histamine release gastrin from G-cells via H2-receptors; this might contribute to H. pylori-associated hypergastrinaemia. (+info)Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. (3/137)
BACKGROUND AND OBJECTIVE: Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors. The association between chronic hepatitis C and progression to cirrhosis and hepatocellular carcinoma has been reported in about 20% and 5% of patients, respectively, within 20-30 years of infection. In adult patients, interferon has proved to be effective in decreasing the abnormal values of transaminases and the level of HCV viremia. Our purpose was to assess efficacy of and tolerance to interferon in a group of young patients who had acquired HCV infection during a period of chemotherapy. DESIGN AND METHODS: Interferon-a (IFN) was administered to 26 adolescents and young adults (13 males, age range 17-36 years; median age 24) with chronic hepatitis C, including 4 with hepatitis B virus co-infection, who had been treated for leukemia or solid tumor 5 to 19 years before joining this trial. Patients were treated with natural IFN alpha at a dose of 4 MU/m(2) thrice weekly for 12 months and followed up for another 6 months thereafter. RESULTS: Nine patients stopped treatment during the first 6 months because of side effects (2 cases) or lack of response. At the end of the trial, 8 (31%) cases had responded, with alanine amino-transferase normalization and clearance of hepatitis C virus (HCV) RNA. A sustained response was only documented in 15% of cases, however, irrespective of any hepatitis B virus co-infection. The 2 patients with HCV genotype 2 were both responders, whereas only 8% of those with genotype 1 responded. INTERPRETATION AND CONCLUSIONS: These data show that the efficacy of IFN in this series of young patients is similar to that reported for otherwise healthy adults with hepatitis C. Patients with genotype 2 are strong candidates for IFN treatment while other therapeutic strategies should be designed for patients with HCV genotype 1. (+info)Bronchial vasodilation evoked by increased lower airway osmolarity in dogs. (4/137)
Hyperosmotic saline solutions stimulate lower airway sensory nerves. To determine whether airway hyperosmolarity evokes neurally mediated changes in bronchial artery blood flow (Qbr), we measured the effect of injection of small volumes (1 ml) of hyperosmotic saline into a right lobar bronchus on Qbr of anesthetized, artificially ventilated dogs. In 14 dogs, hyperosmotic saline (1,200 and 2,400 mmol/l) increased Qbr by 58 +/- 12 (SE) and 118 +/- 12%, respectively, from a baseline of 8 +/- 2 ml/min. Qbr increased within 6-8 s of the injections, peaked at 20 s, and returned to control over 2-3 min. Isosmotic saline had minimal effects. In contrast, hyperosmotic saline decreased flow in an intercostal artery that did not supply the airways. The bronchial vasodilation was decreased by 72 +/- 11% after combined blockade of alpha-adrenoceptors and muscarinic cholinergic receptors and by 66 +/- 6% when the cervical vagus nerves were cooled to 0 degrees C. Blockade of H(1) and H(2) histamine receptors did not reduce the nonvagal response. We conclude that hyperosmolarity of the lower airways evokes bronchial vasodilation by both a centrally mediated reflex that includes cholinergic and adrenergic efferent pathways and by unidentified local mechanisms. (+info)Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine. (5/137)
Antihistamine induced cognitive decline was evaluated using positron emission tomography (PET) measurement of histamine H1 receptor (H1R) occupancy and regional cerebral blood flow (rCBF). Cognitive performance in attention-demanding task deteriorated dose-dependently and the effects were statistically significant after the treatment of 2 mg of d-chlorpheniramine. There was no significant change in subjective sleepiness in the same dose. The regional blockade of H1R was observed mainly in the frontal, temporal and anterior cingulate cortices, and the intravenous administration of d-chlorpheniramine as a therapeutic dose (2 mg) blocked over 60% of H1R in the frontal cortices. The results from activation study using visual discrimination tasks demonstrated that enhanced activity in the right prefrontal and anterior cingulate cortices as well as a decreased activity in the left temporal and frontal cortices and midbrain after the treatment of d-chlorpheniramine. There were no changes in global CBF for the subjects treated with 2 mg d-chlorpheniramine (pre; 44.8+/-3.3 ml dl(-1) min(-1) vs post; 44.4+/-4.7 ml dl(-1) min(-1)). The results indicated that the attention system of human brain could be altered by therapeutic doses of H1R antagonists. These findings provide the information as to the potential risk of antihistamines in our daily activities. British Journal of Pharmacology (2000) 129, 115 - 123 (+info)Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. (6/137)
We investigated the effect of stimulation of H(1)-receptors with histamine on protein tyrosine phosphorylation levels in guinea-pig left atrium and evaluated the influences of tyrosine kinase inhibitors on the positive inotropic effect mediated by H(1)-receptors in this tissue. Histamine induced an increase in tyrosine phosphorylation in four main clusters of proteins with apparent molecular weights of 25, 35, 65 and 150 kDa. Tyrosine phosphorylation of these proteins attained a peak around 2 - 3 min following histamine stimulation and then declined to or below basal levels. Histamine-induced protein tyrosine phosphorylation was antagonized by the H(1)-receptor antagonists mepyramine (1 microM) and chlorpheniramine (1 microM), but not by the H(2)-receptor antagonist cimetidine (10 microM). The positive inotropic effect of histamine was depressed in a concentration-dependent manner by the tyrosine kinase inhibitors tyrphostin A25 (50 to 100 microM) and genistein (10 to 50 microM) but not by the inactive genistein analogue daidzein (50 microM). The positive inotropic effect of isoprenaline was unchanged by tyrphostin A25 and genistein. At a concentration of 1 microM histamine produced a dual-component positive inotropic response composed of an initial increasing phase and a second and late developing, greater positive inotropic phase. Treatment with tyrphostin A25 (100 microM) and genistein (50 microM), but not daidzein (50 microM), significantly attenuated the two components of the inotropic response, although genistein suppressed the initial component more markedly than the late component. We conclude that increased protein tyrosine phosphorylation may play an important role in initiating at least some part of the positive inotropic effect of H(1)-receptor stimulation in guinea-pig left atrium. (+info)Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats. (7/137)
The study was designed to determine the cardiovascular effects of histamine administered intracerebroventricularly (icv) in a rat model of volume-controlled haemorrhagic shock. The withdrawal of approximately 50% of total blood volume resulted in the death of all control saline icv treated animals within 30 min. Icv injection of histamine produced a prompt dose-dependent (0.1-100 nmol) and long-lasting (10-100 nmol) increase in mean arterial pressure (MAP), pulse pressure (PP) and heart rate (HR), with a 100% survival of 2h after treatment (100 nmol). The increase in MAP and HR after histamine administration in bled rats in comparison to the normovolaemic animals was 2.7-3.3- and 1.3-3.6-fold higher, respectively. Pretreatment with chlorpheniramine (50 nmol icv), H1 receptor antagonist, inhibited the increase in MAP, PP, HR and survival rate produced by histamine, while chlorpheniramine given alone had no effect. Neither ranitidine (50 nmol icv), H2 histamine receptor antagonist, nor thioperamide (50 nmol icv), H3 receptor blocker, influenced the histamine action, however, when given alone, both evoked the pressor effect with elongation of survival time. It can be concluded that histamine administered icv reverses the haemorrhagic shock conditions, and histamine H1 receptors are involved. (+info)Painless thyroiditis induced by the cessation of betamethasone. (8/137)
We describe the first reported case of painless thyroiditis induced by an abrupt cessation of betamethasone. A 53-year-old woman experienced transient thyrotoxicosis after the abrupt cessation of celestamine, a mixture of betamethasone and chlorpheniramine. Since neither TSH receptor- nor thyroid stimulating-antibodies were negative, and thyroid scintigram did not show the thyroid gland, she was diagnosed as having painless thyroiditis. Fourteen months after the onset of thyrotoxicosis, serum TSH was detectable without hypothyroidism. We speculate that reduction in betamethasone may be one of the triggers of painless thyroiditis. (+info)Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride Discounts and Coupons - Cheaper Chlorpheniramine Maleate and...
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CHLORPHENIRAMINE MALEATE (UNII: V1Q0O9OJ9Z) (CHLORPHENIRAMINE - UNII:3U6IO1965U) CHLORPHENIRAMINE MALEATE. 1 mg in 5 mL. ... acetaminophen 160 MG / chlorpheniramine maleate 1 MG / dextromethorphan HBr 5 MG / phenylephrine HCl 2.5 MG in 5 mL Oral ... acetaminophen 160 MG / chlorpheniramine maleate 1 MG / dextromethorphan HBr 5 MG / phenylephrine HCl 2.5 MG per 5 ML Oral ... acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine hydrochloride suspension. Product ...
Is chlorpheniramine the same as Zyrtec?
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Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg of ... Drug: Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg ... Drug: Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg ... Drug Information available for: Chlorpheniramine maleate Hydrocodone Chlorphenamine Hydrocodone bitartrate Hycodan U.S. FDA ...
Interactions with Acetaminophen, Chlorpheniramine, and Pseudoephedrine | Complementary and Alternative Medicine | St. Luke's...
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Buy Chlor Maleate (chlorpheniramine maleate) Online | Blink Health
Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. ... Before taking chlorpheniramine, tell your doctor or pharmacist if you are allergic to it; or to dexchlorpheniramine; or if you ... Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms ... Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms ...
Morphine (Injection Route) Description and Brand Names - Mayo Clinic
This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in the diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. Dizziness, lightheadedness, or fainting may occur when you or your child get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness. This medicine may make you dizzy, drowsy, confused, or disoriented. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Before having any kind of surgery ...
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CHLORPHENIRAMINE MALEATE. [Chlorpheniramine (Maleate):4mg]. Tabs. 1000s. 0.00 0.00 CHLORPHENIRAMINE MALEATE. [Chlorpheniramine ... Chlorpheniramine (Maleate):2mg/5ml]. Syrup. 60ml. 0.00 0.00 CHLORPHENIRAMINE MALEATE. [Chlorpheniramine (Maleate):2mg/5ml]. ... CHLORPHENIRAMINE MALEATE. [Chlorpheniramine (Maleate):2mg/5ml]. Syrup. 450ml. 0.00 0.00 ... CHLORPHENIRAMINE MALEATE. JAWA PHARMACEUTICALS(PVT) LTD.. Click on a Brand to view Alternate Brands of same Drug dosage. Brand ...
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IMSEAR at SEARO: Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage...
Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms.. Authors: ... Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms. ... A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropa-nolamine ...
Phenylephrine hydrochlorideChlor-TrimetonAntihistamineParacetamolAcetaminophenSyrupDextromethorphan HydrobromidePSEUDOEPHEDRINEDetermination of chlorpheniramineTabletsHistamineAntiallergic which helpsAllergicDoseCough and coldTabletDrugsRelievesSymptomsAdultsMedicationsSide effectsIndiaCombination productMedicationManufacturerDisease
Phenylephrine hydrochloride1
- we are offering Phenylephrine Hydrochloride And Chlorpheniramine Maleate Syrup is utilized to treat manifestations of a hypersensitivity, cold, or sinus irritation. (kaps3.in)
Chlor-Trimeton1
- Chlor-Trimeton (chlorpheniramine maleate) and Zyrtec (cetirizine hydrochloride) are antihistamines used to treat sneezing, itching, watery eyes, and runny nose caused by allergies or the common cold. (onteenstoday.com)
Antihistamine5
- Chlorpheniramine is an antihistamine. (emedicinehealth.com)
- Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. (blinkhealth.com)
- Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. (paleymd.com)
- Chlorpheniramine maleate (brand names: Chlor-Trimetron®, Aller-chlor®, Chlor-tripolon®, ChlorTabs ®) is an antihistamine used to treat allergic conditions and occasionally used as a mild sedative. (stonebridgevethospital.com)
- Chlorpheniramine maleate is an antihistamine which may cause drowsiness. (northwestpharmacy.com)
Paracetamol6
- Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets which are used in the treatment of common cold symptoms. (adenhealthcare.com)
- Take a single dose of Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets three times a day for better results. (adenhealthcare.com)
- Take these Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets daily or do not skip any of the doses for better results. (adenhealthcare.com)
- Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets rarely cause any kind of serious side effects. (adenhealthcare.com)
- Manufacturer of a wide range of products which include dextromethorphan 10mg,phenylephrine 5mg, chlorpheniramine maleate 2mg (intocough syrup) and paracetamol 125mg, phenylepherine hydrochloride 2.5 mg & cpm syrup 1mg intogest. (integratedlaboratories.net)
- Efficacy and Safety of a Fixed Dose Combination of Paracetamol, Chlorpheniramine Maleate, Phenylephrine and Caffeine in Treatment of Common Cold: A Phase IV, Open-Labelled, Multi-Centric Study. (aimdrjournal.com)
Acetaminophen6
- chlorpheniramine-pseudoeph-dextromethorph-acetaminophen oral decreases levels of tiludronate oral by reducing drug absorption from the stomach and intestine into the body when taken by mouth. (rxlist.com)
- chlorpheniramine-pseudoeph-dextromethorph-acetaminophen oral decreases levels of tiludronate oral by inhibition of GI absorption. (rxlist.com)
- What is acetaminophen / chlorpheniramine / dextromethorphan? (rxless.com)
- When you get a acetaminophen-chlorpheniramine-dextromethorphan discount card for free from rxless, you'll pay the lowest possible price for your medication. (rxless.com)
- To get started, check the section below for other drugs related to acetaminophen-chlorpheniramine-dextromethorphan. (rxless.com)
- The next morning, she sought medical attention and was prescribed chlorpheniramine and acetaminophen. (cdc.gov)
Syrup4
- Chlorpheniramine maleate is given by mouth in the form of a tablet, liquid syrup, or liquid drops. (stonebridgevethospital.com)
- Our clients can avail this Hydrochloride And Chlorpheniramine Maleate Syrup at a practical cost. (kaps3.in)
- Pioneers in the industry, we offer levodropropizine chlorpheniramine maleate syrup, simethicone 40mg , dill oil 0.005 ml and fennel oil 0.007 ml suspension, calcium ,vitamin d3 , methylcobalamin, l- methylfolate calcium & pyridoxal-5- phosphate tablets and terbutaline sulphate bromexine hydrochloride methenol syrup from India. (saphnixlifesciences.in)
- Chlorpheniramine is available in 2 mg, 4 mg, 8 mg, 12 mg and 16 mg tablets and as a 2-mg/5 ml oral syrup. (petplace.com)
Dextromethorphan Hydrobromide1
- Coricidin II Cold & Flu contains 30 mg dextromethorphan Hydrobromide and 2 mg chlorpheniramine maleate and is available without a prescription from your doctor. (northwestpharmacy.com)
PSEUDOEPHEDRINE5
- Are you currently using Chlorpheniramine-pseudoephedrine ER Oral? (webmd.com)
- What is chlorpheniramine, dextromethorphan, and pseudoephedrine? (emedicinehealth.com)
- Chlorpheniramine, dextromethorphan, and pseudoephedrine is a combination medicine used to treat cough , runny or stuffy nose, sneezing, itching, and watery eyes caused by allergies , the common cold , or the flu . (emedicinehealth.com)
- Chlorpheniramine, dextromethorphan, and pseudoephedrine may also be used for purposes not listed in this medication guide. (emedicinehealth.com)
- Do not use chlorpheniramine, dextromethorphan, and pseudoephedrine if you have used an MAO inhibitor in the past 14 days. (emedicinehealth.com)
Determination of chlorpheniramine3
- IMSEAR at SEARO: Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms. (who.int)
- A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropa-nolamine Hydrochloride (PPM) by first derivative UV spectrophotometry has been developed in combined pharmaceutical dosage forms. (who.int)
- A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen) 3 2+ ] and peroxydisulphate (S 2 O 8 2- ) in the presence of light. (elsevier.com)
Tablets1
- Chlorpheniramine Maleate Tablets "S.S.P. (lehyinn.com)
Histamine8
- Increased ornithine decarboxylase activity induced in an is chemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. (xahnb.com)
- Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. (xahnb.com)
- The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate. (xahnb.com)
- Chlorpheniramine maleate is a type of anti-histamine drug commonly used in dogs with allergies to control itching. (petplace.com)
- In eight subjects, the administration of 10 mg chlorpheniramine intravenously increased the TD of histamine four times (the ratio of TD histamine chlorpheniramine/TD histamine was four), whereas in one subject, the same amount of chlorpheniramine exhibited a dose-ratio of 8 (Fig 2). (onlineasthmainhalers.com)
- In one of these two subjects, 15 mg chlorpheniramine intravenously increased the TD to allergen twice (Fig 3) and the TD to histamine 8 times (Fig 2). (onlineasthmainhalers.com)
- Influence of chlorpheniramine injected intravenously on threshold dose of inhaled histamine. (onlineasthmainhalers.com)
- Chlorpheniramine competes with histamine or H1 receptor sites on effector cells in blood vessels and the respiratory tract. (medscape.com)
Antiallergic which helps1
- Chlorpheniramine Maleate is also known as antiallergic which helps in treating allergy symptoms like runny nose, watery eyes, and sneezing. (adenhealthcare.com)
Allergic3
- tell your doctor and pharmacist if you are allergic to chlorpheniramine, any other medications, or any of the ingredients in the chlorpheniramine product you plan to use. (medlineplus.gov)
- You should not use this medicine if you are allergic to chlorpheniramine, hydrocodone, or phenylephrine. (paleymd.com)
- Chlorpheniramine maleate should not be used in pets that are allergic to it or other similar antihistamines. (stonebridgevethospital.com)
Dose4
- The objective of this open-label, randomized, two-period, crossover study was to evaluate the oral bioavailability of the Mallinckrodt extended release test capsule formulation of chlorpheniramine polistirex/hydrocodone polistirex compared to an equivalent oral dose of a commercially available extended release oral suspension of chlorpheniramine polistirex/hydrocodone polistirex (Tussionex® Pennkinetic® Extended Release Oral Suspension, Celltech Pharmaceuticals, Inc.) in a test group of healthy subjects under fasting conditions. (clinicaltrials.gov)
- One of subjects with TD of H of 0.16 mg, was tested first with chlorpheniramine, 10 mg, and his TD of H increased to 0.64 mg-one of the closed circles at this dose level-and then with 15 mg chlorpheniramine. (onlineasthmainhalers.com)
- Effect on threshold dose of allergen of dose of atropine having an anticholinergic activity similar to anticholinergic activity of 10 or 15 mg chlorpheniramine given intravenously. (onlineasthmainhalers.com)
- Left panel: influence of intravenously given chlorpheniramine on threshold dose of acetylcholine. (onlineasthmainhalers.com)
Cough and cold1
- Nonprescription cough and cold combination products, including products that contain chlorpheniramine, can cause serious side effects or death in young children. (medlineplus.gov)
Tablet1
- Chlorpheniramine comes as a tablet, a capsule, an extended-release (long-acting) tablet and capsule, a chewable tablet, and a liquid to take by mouth. (medlineplus.gov)
Drugs1
- The physicochemical characteristics of these spheroids were examined and compared against MCC-Ioaded alginate spheroids using chlorpheniramine maleate and tolbutamide as water-soluble and poorly water-soluble drugs respectively. (uitm.edu.my)
Relieves1
- Chlorpheniramine Maleate + Levodropropizine is a combination of two medicines: Chlorpheniramine Maleate and Levodropropizine, which relieves dry cough . (saphnixlifesciences.in)
Symptoms1
- Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. (medlineplus.gov)
Adults1
- Do not give chlorpheniramine products that are made for adults to children. (medlineplus.gov)
Medications2
- Chlorpheniramine is in a class of medications called antihistamines. (medlineplus.gov)
- The following medications should be used with caution when given with chlorpheniramine maleate: anticoagulants, MAOIs, phenytoin, or central nervous system depressants. (stonebridgevethospital.com)
Side effects1
- Alcohol can make the side effects of chlorpheniramine worse. (medlineplus.gov)
India1
- Manus Aktteva Biopharma LLP is an ISO 9001:2015 Certified Global Supplier based in India for the product Chlorpheniramine maleate, 113-92-8. (manusaktteva.com)
Combination product1
- If you are giving chlorpheniramine or a combination product that contains chlorpheniramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. (medlineplus.gov)
Medication3
- Before you give a chlorpheniramine product to a child, check the package label to find out how much medication the child should receive. (medlineplus.gov)
- Chlorpheniramine, hydrocodone, and phenylephrine may also be used for purposes not listed in this medication guide. (paleymd.com)
- If purchased over the counter, read the label carefully before giving this medication to ensure the product contains ONLY chlorpheniramine . (stonebridgevethospital.com)
Manufacturer2
- We offer the product Chlorpheniramine maleate, 113-92-8 from our manufacturer / supplier / principals for your Research and Development / Evaluation or Commercial requirements, based on the product's availability from our network. (manusaktteva.com)
- If you are looking for the API -Active Pharmaceutical Ingredients Chlorpheniramine maleate, 113-92-8 manufacturer supplier who is reliable and meets your required quality standard requirements in the first place, you are at the right place! (manusaktteva.com)
Disease1
- Chlorpheniramine is contraindicated in dogs with glaucoma, lung disease, heart disease, high blood pressure and prostate gland enlargement. (petplace.com)