Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Histamine H1 Antagonists: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.Receptors, Histamine H1: A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)Butyrophenones: Compounds containing phenyl-1-butanone.Dimethindene: A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.Histamine Antagonists: Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.Triprolidine: Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Receptors, Histamine H2: A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.Metiamide: A histamine H2 receptor antagonist that is used as an anti-ulcer agent.Receptors, Histamine: Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.Burimamide: An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.Histamine H2 Antagonists: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.Clemastine: A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.Methylhistamines: Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.Histamine Agonists: Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.Impromidine: A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Health Status: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Delivery of Health Care: The concept concerned with all aspects of providing and distributing health services to a patient population.Health Surveys: A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.Mental Health: The state wherein the person is well adjusted.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.Expectorants: Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.Levorphanol: A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.Self-Help Groups: Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.Psychotherapy, Group: A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.MaleatesPigmentation DisordersBody Water: Fluids composed mainly of water found within the body.Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Muscle Strength: The amount of force generated by MUSCLE CONTRACTION. Muscle strength can be measured during isometric, isotonic, or isokinetic contraction, either manually or using a device such as a MUSCLE STRENGTH DYNAMOMETER.

Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system. (1/137)

Transport characteristics of diphenhydramine, an antihistamine, were studied in cultured human intestinal Caco-2 cell monolayers to elucidate the mechanisms of its intestinal absorption. Diphenhydramine accumulation in the monolayers increased rapidly and was influenced by extracellular pH (pH 7.4 > 6.5 > 5.5). Diphenhydramine uptake was temperature dependent, saturable, and not potential sensitive. Kinetic analysis revealed that the apparent Km values were constant (0.8-1.0 mM) in all pH conditions tested, whereas Vmax values decreased at the lower pH. The initial uptake of diphenhydramine was competitively inhibited by another antihistamine, chlorpheniramine, with a Ki value of 1.3 mM. On the other hand, cimetidine and tetraethylammonium, typical substrates for the renal organic cation transport system, had no effect. Moreover, biological amines and neurotransmitters, such as histamine, dopamine, serotonin, and choline, also had no effect on the diphenhydramine accumulation. Finally, diphenhydramine uptake was stimulated by preloading monolayers with chlorpheniramine (trans-stimulation effect). These findings indicate that diphenhydramine transport in Caco-2 cells is mediated by a specific transport system. This pH-dependent transport system may contribute to the intestinal absorption of diphenhydramine.  (+info)

Nalpha-methyl histamine and histamine stimulate gastrin release from rabbit G-cells via histamine H2-receptors. (2/137)

BACKGROUND: Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin release. H. pylori is reported to produce Nalpha-methyl histamine (NalphaMH), which is an agonist of H3 as well as other histamine receptors. H. pylori infection also recruits mast cells, which release histamine. AIM: To determine the direct effects of histamine receptor agonists on isolated gastrin cells. METHODS: Rabbit G-cells were prepared by countercurrent elutriation and cultured on 24-well plates. RESULTS: NalphaMH (10-6-10-4 M) caused a dose-dependent increase in gastrin release from a basal level of 2.3 +/- 0.2% total cell content (TCC; mean +/- S.E.M.) to a maximum of 5.1 +/- 0.7%, an increase of 117% (P < 0. 005) above basal. This was abolished by the H2-antagonist ranitidine (10-5 M), but not by immunoblockade with anti-somatostatin antibody, the H1-antagonist chlorpheniramine (10-5 M) or the H3-antagonist thioperamide (10-4 M). The histamine H2-receptor agonist dimaprit (10-6-10-4 M) increased gastrin release from 2.4 +/- 0.2% to 3.6 +/- 0.2% TCC (P < 0.001). Gastrin release was also stimulated by histamine (10-7-10-4 M) from a basal value of 3.0 +/- 0.3% to 5.4 +/- 0.5% TCC (P < 0.001). This also was inhibited by ranitidine (10-5 M) (P < 0.01). CONCLUSION: NalphaMH and histamine release gastrin from G-cells via H2-receptors; this might contribute to H. pylori-associated hypergastrinaemia.  (+info)

Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. (3/137)

BACKGROUND AND OBJECTIVE: Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors. The association between chronic hepatitis C and progression to cirrhosis and hepatocellular carcinoma has been reported in about 20% and 5% of patients, respectively, within 20-30 years of infection. In adult patients, interferon has proved to be effective in decreasing the abnormal values of transaminases and the level of HCV viremia. Our purpose was to assess efficacy of and tolerance to interferon in a group of young patients who had acquired HCV infection during a period of chemotherapy. DESIGN AND METHODS: Interferon-a (IFN) was administered to 26 adolescents and young adults (13 males, age range 17-36 years; median age 24) with chronic hepatitis C, including 4 with hepatitis B virus co-infection, who had been treated for leukemia or solid tumor 5 to 19 years before joining this trial. Patients were treated with natural IFN alpha at a dose of 4 MU/m(2) thrice weekly for 12 months and followed up for another 6 months thereafter. RESULTS: Nine patients stopped treatment during the first 6 months because of side effects (2 cases) or lack of response. At the end of the trial, 8 (31%) cases had responded, with alanine amino-transferase normalization and clearance of hepatitis C virus (HCV) RNA. A sustained response was only documented in 15% of cases, however, irrespective of any hepatitis B virus co-infection. The 2 patients with HCV genotype 2 were both responders, whereas only 8% of those with genotype 1 responded. INTERPRETATION AND CONCLUSIONS: These data show that the efficacy of IFN in this series of young patients is similar to that reported for otherwise healthy adults with hepatitis C. Patients with genotype 2 are strong candidates for IFN treatment while other therapeutic strategies should be designed for patients with HCV genotype 1.  (+info)

Bronchial vasodilation evoked by increased lower airway osmolarity in dogs. (4/137)

Hyperosmotic saline solutions stimulate lower airway sensory nerves. To determine whether airway hyperosmolarity evokes neurally mediated changes in bronchial artery blood flow (Qbr), we measured the effect of injection of small volumes (1 ml) of hyperosmotic saline into a right lobar bronchus on Qbr of anesthetized, artificially ventilated dogs. In 14 dogs, hyperosmotic saline (1,200 and 2,400 mmol/l) increased Qbr by 58 +/- 12 (SE) and 118 +/- 12%, respectively, from a baseline of 8 +/- 2 ml/min. Qbr increased within 6-8 s of the injections, peaked at 20 s, and returned to control over 2-3 min. Isosmotic saline had minimal effects. In contrast, hyperosmotic saline decreased flow in an intercostal artery that did not supply the airways. The bronchial vasodilation was decreased by 72 +/- 11% after combined blockade of alpha-adrenoceptors and muscarinic cholinergic receptors and by 66 +/- 6% when the cervical vagus nerves were cooled to 0 degrees C. Blockade of H(1) and H(2) histamine receptors did not reduce the nonvagal response. We conclude that hyperosmolarity of the lower airways evokes bronchial vasodilation by both a centrally mediated reflex that includes cholinergic and adrenergic efferent pathways and by unidentified local mechanisms.  (+info)

Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine. (5/137)

Antihistamine induced cognitive decline was evaluated using positron emission tomography (PET) measurement of histamine H1 receptor (H1R) occupancy and regional cerebral blood flow (rCBF). Cognitive performance in attention-demanding task deteriorated dose-dependently and the effects were statistically significant after the treatment of 2 mg of d-chlorpheniramine. There was no significant change in subjective sleepiness in the same dose. The regional blockade of H1R was observed mainly in the frontal, temporal and anterior cingulate cortices, and the intravenous administration of d-chlorpheniramine as a therapeutic dose (2 mg) blocked over 60% of H1R in the frontal cortices. The results from activation study using visual discrimination tasks demonstrated that enhanced activity in the right prefrontal and anterior cingulate cortices as well as a decreased activity in the left temporal and frontal cortices and midbrain after the treatment of d-chlorpheniramine. There were no changes in global CBF for the subjects treated with 2 mg d-chlorpheniramine (pre; 44.8+/-3.3 ml dl(-1) min(-1) vs post; 44.4+/-4.7 ml dl(-1) min(-1)). The results indicated that the attention system of human brain could be altered by therapeutic doses of H1R antagonists. These findings provide the information as to the potential risk of antihistamines in our daily activities. British Journal of Pharmacology (2000) 129, 115 - 123  (+info)

Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. (6/137)

We investigated the effect of stimulation of H(1)-receptors with histamine on protein tyrosine phosphorylation levels in guinea-pig left atrium and evaluated the influences of tyrosine kinase inhibitors on the positive inotropic effect mediated by H(1)-receptors in this tissue. Histamine induced an increase in tyrosine phosphorylation in four main clusters of proteins with apparent molecular weights of 25, 35, 65 and 150 kDa. Tyrosine phosphorylation of these proteins attained a peak around 2 - 3 min following histamine stimulation and then declined to or below basal levels. Histamine-induced protein tyrosine phosphorylation was antagonized by the H(1)-receptor antagonists mepyramine (1 microM) and chlorpheniramine (1 microM), but not by the H(2)-receptor antagonist cimetidine (10 microM). The positive inotropic effect of histamine was depressed in a concentration-dependent manner by the tyrosine kinase inhibitors tyrphostin A25 (50 to 100 microM) and genistein (10 to 50 microM) but not by the inactive genistein analogue daidzein (50 microM). The positive inotropic effect of isoprenaline was unchanged by tyrphostin A25 and genistein. At a concentration of 1 microM histamine produced a dual-component positive inotropic response composed of an initial increasing phase and a second and late developing, greater positive inotropic phase. Treatment with tyrphostin A25 (100 microM) and genistein (50 microM), but not daidzein (50 microM), significantly attenuated the two components of the inotropic response, although genistein suppressed the initial component more markedly than the late component. We conclude that increased protein tyrosine phosphorylation may play an important role in initiating at least some part of the positive inotropic effect of H(1)-receptor stimulation in guinea-pig left atrium.  (+info)

Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats. (7/137)

The study was designed to determine the cardiovascular effects of histamine administered intracerebroventricularly (icv) in a rat model of volume-controlled haemorrhagic shock. The withdrawal of approximately 50% of total blood volume resulted in the death of all control saline icv treated animals within 30 min. Icv injection of histamine produced a prompt dose-dependent (0.1-100 nmol) and long-lasting (10-100 nmol) increase in mean arterial pressure (MAP), pulse pressure (PP) and heart rate (HR), with a 100% survival of 2h after treatment (100 nmol). The increase in MAP and HR after histamine administration in bled rats in comparison to the normovolaemic animals was 2.7-3.3- and 1.3-3.6-fold higher, respectively. Pretreatment with chlorpheniramine (50 nmol icv), H1 receptor antagonist, inhibited the increase in MAP, PP, HR and survival rate produced by histamine, while chlorpheniramine given alone had no effect. Neither ranitidine (50 nmol icv), H2 histamine receptor antagonist, nor thioperamide (50 nmol icv), H3 receptor blocker, influenced the histamine action, however, when given alone, both evoked the pressor effect with elongation of survival time. It can be concluded that histamine administered icv reverses the haemorrhagic shock conditions, and histamine H1 receptors are involved.  (+info)

Painless thyroiditis induced by the cessation of betamethasone. (8/137)

We describe the first reported case of painless thyroiditis induced by an abrupt cessation of betamethasone. A 53-year-old woman experienced transient thyrotoxicosis after the abrupt cessation of celestamine, a mixture of betamethasone and chlorpheniramine. Since neither TSH receptor- nor thyroid stimulating-antibodies were negative, and thyroid scintigram did not show the thyroid gland, she was diagnosed as having painless thyroiditis. Fourteen months after the onset of thyrotoxicosis, serum TSH was detectable without hypothyroidism. We speculate that reduction in betamethasone may be one of the triggers of painless thyroiditis.  (+info)

*Recall (memory)

3.0.co;2-5. Carter, S. J.; Cassaday, H. J. (1998). "State-Dependent Retrieval and Chlorpheniramine". Human ...

*Brompheniramine

... is an analog of chlorpheniramine. The only difference is that the chlorine atom in the benzene ring is replaced ... chlorpheniramine, dexchlorpheniramine (Polaramine), triprolidine (Actifed), and iodopheniramine. The halogenated alkylamine ...

*Vicks 44 Pediatric

Active ingredients include dextromethorphan, pseudoephedrine and chlorpheniramine. The combination of antihistamine, de- ...

*Chlorphenamine

... is the INN while chlorpheniramine is the USAN and former BAN. Yasuda SU, Wellstein A, Likhari P, Barbey JT, ... Hellbom, E. (2006). "Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment". ... Chlorphenamine (also known as chlorpheniramine, CP, or CPM) is a first-generation antihistamine used in the prevention of the ... Miyata S, Hirano S, Ohsawa M, Kamei J (2011). "Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT ...

*Hydroxyzine/reference table

Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther 1995;58:210-20. Gendreau-Reid L ...

*Dexchlorpheniramine

It is the pharmacologically active dextrorotatory isomer of chlorpheniramine. Dexchlorpheniramine is an antihistamine, or an ...

*Corex

Alcohol IP 8 mg Chlorpheniramine Maleate IP 4 mg Codeine Phosphate IP 10 mg Carmoisine and Sunset Chlorpheniramine maleate, an ... Its active ingredients are chlorpheniramine maleate and codeine phosphate. Each 5 ml of Corex Cough Syrup contains: ...

*Allergic conjunctivitis

Antihistamines such as diphenhydramine and chlorpheniramine are commonly used as treatment. People treated with H1 ...

*Cunninghamella elegans

It is also able to transform the antihistamines brompheniramine, chlorpheniramine and pheniramine. It forms a glucoside with ... chlorpheniramine, and pheniramine toN-oxide andN-demethylated metabolites by the fungusCunninghamella elegans". Xenobiotica. 25 ...

*Coricidin

Another danger is chlorpheniramine's notably long half life (about a whole day), which may result in high levels of it building ... Chlorpheniramine is an anticholinergic that can cause very serious reactions in high doses.[vague][citation needed] This may be ... and chlorpheniramine maleate (an antihistamine). Varieties of Coricidin may also contain acetaminophen (an analgesic/ ... Chlorpheniramine Dextromethorphan "Coricidin HBP Cough and Cold", WebMD. Retrieved 7 January 2017. Henigig, Christian. Missing ...

*Selective serotonin reuptake inhibitor

Hellbom E (2006). "Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment". Med ...

*Serotonin reuptake inhibitor

Hellbom E (2006). "Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment". Med ... some clinically used drugs such as chlorpheniramine, dextromethorphan, and methadone possess SRI properties secondarily to ... Chlorpheniramine (Chlor-Trimeton) Dextromethorphan (DXM; Robitussin) Dextropropoxyphene (Darvon) Dimenhydrinate (Dramamine) ...

*Anxiolytic

However, in practice, hydroxyzine is rarely as efficacious as the benzodiazepines.[citation needed] Chlorpheniramine (Chlor- ... Miyata, Shigeo; Hirano, Shoko; Ohsawa, Masahiro; Kamei, Junzo (2009). "Chlorpheniramine exerts anxiolytic-like effects and ...

*Tylenol (brand)

A form that contains dextromethorphan, pseudoephedrine, acetaminophen, and chlorpheniramine, is sold as Cotylenol. As of 2017, ... chlorpheniramine and phenylephrine. The brand was introduced in 1955 by McNeil Laboratories, a family owned pharmaceutical ...

*Codeine

... is also present in various cough syrups as codeine phosphate including chlorpheniramine maleate. Pure codeine is also ... chlorpheniramine (2 mg) and codeine (9.5 mg). Preparations containing pure codeine (e.g., codeine phosphate tablets or codeine ...

*Anticholinergic

Examples of common anticholinergics: Antimuscarinic agents Atropine Benztropine (Cogentin) Biperiden Chlorpheniramine (Chlor- ... hydrocodone polistirex/chlorpheniramine). However, it is noted that opioid/antihistamine combinations are used clinically for ...

*Robitussin

Chlorpheniramine (maleate) Chlorpheniramine is an antihistamine found in various children's cough and cold syrups. ...

*Physical urticaria

"Factitious Urticaria (dermographism): Treatment by Cimetidine and Chlorpheniramine in a Randomized Double-blind Study." Br J ...

*Muscarinic antagonist

Yasuda SU, Yasuda RP (1999). "Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic ...

*Tuberculosis management

Short courses of sedative antihistamines such as chlorpheniramine may be useful in alleviating the itch. Fever during treatment ...

*H1 antagonist

... chlorpheniramine (Chlor-Trimeton), and brompheniramine (Dimetane). However, a 1955 study of "antihistaminic drugs for colds," ... Chlorpheniramine (Chlor-Trimeton) Dimenhydrinate (Dramamine, Gravol) - combination of diphenhydramine and 8-chlorotheophylline ...

*Recreational use of dextromethorphan

Multi-symptom cold medicines contain other active ingredients, such as paracetamol (acetaminophen), chlorpheniramine, and ... this brand presents a danger when used at recreational doses due to the presence of chlorpheniramine. In over-the-counter ...

*Cold capsule

Both products contained chlorpheniramine maleate (an antihistamine) and phenylpropanolamine hydrochloride (a decongestant) but ... Both products contained 75 mg of phenylpropanolamine hydrochloride, but Cold Capsule IV contained 12 mg chlorpheniramine ...

*Prednazate

... and chlorpheniramine. Prednazoline Prednimustine J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical ...

*Paracetamol

Sometimes a third active ingredient, such as ascorbic acid, caffeine, chlorpheniramine maleate, or guaifenesin is added to this ...
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Advise the patient to read the FDA-approved patient labeling (Medication Guide).. Addiction, Abuse, and Misuse Inform patients that the use of Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension, even when taken as recommended, can result in addiction, abuse, and misuse, which can lead to overdose and death [see Warnings and Precautions (5.1)]. Instruct patients not to share Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension with others and to take steps to protect Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension from theft or misuse.. Important Dosing and Administration Instructions Instruct patients how to measure and take the correct dose of Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension. Advise patients to measure Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension with an accurate milliliter measuring device. Patients should be ...
SANAFLU XTRA (acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine hydrochloride capsule, gelatin coated) can come in different packaging based on the dosage and strength of the medication. Below are pictures of Sanaflu Xtra packaging to help you recognize it.
SIMULTANEOUS ESTIMATION & VALIDATION OF PARACETAMOL, PHENYLEPHRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE IN TABLETS BY SPECTROPHOTOMETRIC METHOD
The FDA requires all potential medication risks for BC SINUS CONGESTION AND PAIN (acetaminophen, chlorpheniramine maleate, phenylephrine hydrochloride powder) be disclosed to consumers, no matter how rare. Here are the warnings and precautions for BC Sinus Congestion and Pain.
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947 medications are known to interact with acetaminophen/chlorpheniramine/phenylephrine. Includes acetaminophen/chlorpheniramine, acetaminophen/chlorpheniramine/dextromethorphan/phenylephrine, acetaminophen/chlorpheniramine/phenylephrine.
Chlorpheniramine + codeine + sodium citrate + menthol is used in the treatment of .get complete information about chlorpheniramine + codeine + sodium citrate + menthol including usage, side effects, drug interaction, expert advice along with medicines associated with chlorpheniramine + codeine + sodium citrate + menthol at 1mg.com
TITLE: Chlor-Trimeton Chlorpheniramine Maleate Antihistamine, 12 Hour, Tablets - 24ea Chlorpheniramne Maleate/Antihistamine. Pharmacist recommended....
... is an antihistamine used in many prescription and over-the-counter drugs. This eMedTV segment discusses specific uses, explains how the medicine works, lists possible side effects to be aware of, and more.
Compare to maximum strength sudafed PE® sinus &allergy active ingredients*. *This product is not manufactured or distributed by McNeil consumer healthcare, Division of McNeil-PPC, Inc. owner of the registered trademark Sudafed PE® Sinus and allergy. Maximum Strength Sinus & Allergy For relief of: sinus pressure, sinus & nasal congestion, sneezing, itchy, watery eyes.. Chlorpheniramine Maleate 4 mg. Phenylephrine HCl 10 mg. KEEP OUTER CARTON FOR COMPLETE WARNINGS AND PRODUCT INFORMATION TAMPER EVIDENT- USE ONLY IF BLISTERS ARE INTACT Close ...
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The aim of the present study was to fabricate a thermosensitive gel containing chlorpheniramine maleate (CPM)-loaded nanoparticles following intranasal administration for effective treatment of...
For the precept dish, all its essential to do is scan the menu. Bingeing wouldnt occur because of an absence of diethylcarbamazine citrate and chlorpheniramine maleate tablets. For these fruits add diet and fitness software reviews a part of the fruit remembering that fruit can include quite a couple of calories. A superb fatty liver weight-reduction plan plan will reduce fat consumption without starving your body of the nutritional vitamins, minerals, and vitality it wants to remain wholesome. You ideally want to appreciate muscle to assist within the burning of fats. It too softens the stool and cannot be digested or absorbed into the system. The earth signs, Taurus, Virgo and Capricorn, have a more durable time shedding weight as a result of they let themselves gain weight for a long time earlier than occurring a weight loss program weight loss program. Youll be able to combine clenbuterol with your work out routine to boost weight reduction. Substituting water for these chlorphehiramine ...
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Paracetamol + chlorpheniramine + phenylephrine + zinc gluconate is used in the treatment of .get complete information about paracetamol + chlorpheniramine + phenylephrine + zinc gluconate including usage, side effects, drug interaction, expert advice along with medicines associated with paracetamol + chlorpheniramine + phenylephrine + zinc gluconate at 1mg.com
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Chlorpheniramine is an antihistamine used for acute inflammatory and allergic conditions: snake bites, vaccination reactions, blood transfusion reactions, insect bites, bee stings, itchy skin (atopy) and motion sickness in people and animals.
The evidence for the efficacy of Pd - hist d drops and is derived from studies department of Chlorpheniramine and phenylephrine hydrochloride in overheating the published literature. Results from the study showed that mistrusted the 1064 mg dose studies of Ny - tannic achieved therapeutically relevant plasma concentrations of anorexigen drug myself with a pk profile along that supp
Description of the drug Chlorpheniramine/Pseudoephedrine 24-Hour Sustained-Release Capsules. - patient information, description, dosage and directions. What is Chlorpheniramine/Pseudoephedrine 24-Hour Sustained-Release Capsules!
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Chlorpheniramine can cause blurred vision, dizziness, and drowsiness. This article from the eMedTV site contains a list of other precautions and warnings with chlorpheniramine, including other side effects that may occur with this medication.
DIMETAPP NIGHTTIME COLD EXTRA STRENGTH CAPLETS is a specialty drug on the Reformulary and can be used to treat . Check with your doctor if there are other medications you can take before taking this drug.
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a) Extendryl SR Extended-Release Capsules (chlorpheniramine maleate 8mg/phenylephrine HCL 20 mg/methscopolamine nitrate 2.5mg), in 100 capsules. NDC #0256-0111-01; b) Extendryl JR Extended-Release Capsules (chlorpheniramine maleate 5mg/phenylephrine HCL 10 mg/methscopolamine nitrate 1.25 mg), in 100 capsule bottles. NDC #0256-0177-01. Both products are Rx for the relief of respiratory congestion, allergic rhinitis, vasomotor rhinitis, and allergic skin reactions of urticaria and angioedema. Recall #D-091/092-9. CODE ...
You should not use this medicine if you have had an allergic reaction to chlorpheniramine, or pseudoephedrine. You should not use this medicine if you are using MAO inhibitors such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the last 14 days. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects ...
Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion...
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Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
History of conditions which might contraindicate or require caution be used in the administration of chlorpheniramine/hydrocodone, including: history of renal impairment, hepatic or biliary tract disease, inflammatory bowel disease, ulcerative colitis, constipation, diarrhea, gastrointestinal obstruction or ileus, cardiac disease, hypertension, bladder obstruction, pain or difficulty passing urine, systemic lupus erythematosus, head trauma, increased intracranial pressure, pulmonary disease, asthma, or history of hypersensitivity to any opiate agonists or antihistamines ...
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1. The paper describes the mental disturbances of 44 abusive cases of "BRON," an over-the-counter (OTC) cough suppressant solution containing methylephedrine, codeine, caffeine, and chlorpheniramine. 2. Major psychiatric symptoms observed included hallucinatory-paranoid state and affective disorder. There also were groups which exhibited a combination of the two states and abuse only. 3. The hallucinatory-paranoid state group had a relatively small BRON usage amount, short usage term and few withdrawal symptoms. The affective disorder group, in contrast, had large usage amount, longer usage term, and showed significant autonomic nerve disorders during withdrawal. These tendencies were seen more clearly in the mixed state group. 4. The hallucinatory-paranoid state group showed little or no physical dependence, while that of the affective disorder group was thought to be firmly established. Thus, in the former group, methylephedrine was considered the major behavior modifying drug, while in the ...
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25387-68-2 - OCMSTKFGYJZBIY-IFWQJVLJSA-N - Chlorpheniramine gluconate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
cough decon/anti-histamine ## Some info for you: Hydro PC II Plus Liquid CIII Each 5 mL contains: Hydrocodone Bitartrate 3.5 mg, Phenylephrine Hydrochloride 7.5 mg, Chlorpheniramine Maleate 2 mg NDC: 60258-700-16 Active Chemicals: Chlorpheniramine + Hydrocodone + Phenylephrine • Chlorphenirami
Theraflu is a brand of over-the-counter cold and flu medicines from GSK Consumer Healthcare that contain different groupings of various cold and flu symptom medications. The original version of Theraflu contained acetaminophen (paracetamol) (1000 mg), chlorpheniramine maleate (4 mg), dextromethorphan hydrobromide (30 mg), and pseudoephedrine hydrochloride (60 mg). The Canadian and Swiss version is sold as NeoCitran. A British company, Reckitt Benckiser, markets a similar product as Lemsip (Lemsip is available in a variety of flavours and strengths containing up to 1,000 mg of paracetamol, and 12.2 mg phenylephrine hydrochloride). They also sell Theraflu Warming Relief in day and nighttime varieties, which contain alcohol and acetaminophen. Because pseudoephedrine is used in the production of methamphetamine, the original formula has been removed from production and a number of alternative formulations have been brought to market. In addition, the FDA has severely limited medications that contain ...
Torex Cough Syp Juniour(60ml) Syrup contain dextromethorphan hydrobromide, chlorpheniramine maleate, phenylephrine hydrochloride as generic. Torex Cough Syp Juniour(60ml) mainly use for Acid-related dyspepsia, Congestion, Hypotension.. and the side effects of Torex Cough Syp Juniour(60ml) are Anxiety, reflex bradycardia, tachycardia, arrhythmias, headache, cold extremities..
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Upper respiratory infections are rather frequent in the population, and their treatment consists, in most cases, in the use of symptomatic drugs. Acetaminophen is widely used as an analgesic and antipyretic, whereas chlorpheniramine is an antihistaminic and phenylephrine is a vasoconstrictor with decongestioning activity. The aim of this study is to assess the efficacy and safety of an anti-cold preparation, currently commercialized in Brazil by the name Resfenol, compounded by acetaminophen, chlorpheniramine and phenylephrine for the treatment of cold and flu symptoms in healthy individuals in a randomized, double-blind, placebo-controlled clinical trial.. Healthy volunteers are recruited through panels fixated at Hospital de Clínicas de Porto Alegre, in Brazil, and must answer a screening questionnaire at first contact. One hundred and forty six patients who met the inclusion criteria were included and, after baseline clinical and laboratory evaluation, were randomized to receive either the ...
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.. ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Chlorpheniramine belongs to a group of medications known as first-generation antihistamines. For adults and children 6 years of age and older, it is used to treat symptoms caused by allergies, including itchy and watery eyes, sneezing, runny nose, and skin rash and irritations. It is also used to manage itchy skin caused by insect bites, and other medical conditions like chicken pox or measles. Chlorpheniramine works by blocking the effects of histamine, a substance released by cells in the body that produce allergy symptoms.
Chlor-Tripolon Day and Night: Chlorpheniramine belongs to a group of medications known as first-generation antihistamines. For adults and children 6 years of age and older, it is used to treat symptoms caused by allergies, including itchy and watery eyes, sneezing, runny nose, and skin rash and irritations. It is also used to manage itchy skin caused by insect bites, and other medical conditions like chicken pox or measles. Chlorpheniramine works by blocking the effects of histamine, a substance released by cells in the body that produce allergy symptoms.
WOBIB_127 ] Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine ...
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.. ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. If you have a fever, skin rash, or persistent headache, see your doctor. Do not take this medicine for more than one week unless directed by your doctor. Do not take more than the recommended dose.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.. This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.. If you take too much ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or ...
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. If this medicine upsets your stomach, take with food or milk. Use a specially marked spoon or container to measure your medicine. Household spoons are not accurate. Take your doses at regular intervals. Do not take your medicine more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years old for selected conditions, precautions do apply. Do not give this medicine to children under 2 years old.. Patients over 60 years old may have a stronger reaction and need a smaller dose.. ...
Visit your doctor or health care professional for regular check ups. Tell your doctor if your symptoms do not improve or if they get worse.. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.. This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
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Tritan is also known as object Chlorpheniramine, phenylephrine, and pyrilamine. There is bound no general agreement Chlorpheniramine, phenylephrine, and py
If you are having a medical emergency, call 911 or seek emergency medical help immediately.. We will contact you within 2-3 business days to review your appointment request. Do not use for immediate or urgent care needs. Some specialties may require a referral from a primary care provider prior to scheduling an appointment.. ...
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.. If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all ...
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Author: Allen Loyd V Jr, Year: 2013, Abstract: A formulation for preparing Phenylephrine Hydrochloride 10-mg/mL Injection. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
Impurities in pharmaceuticals are the chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during formulation, or upon aging of both API and formulated APIs to medicines. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry.
Sudafed Blocked Nose Capsules with Phenylephrine hydrochloride effectively clear stuffy noses associated with colds and hay fever, resulting in a clear head.
what is this medicine using for? what is the possible side effect? ## Antamin contains the active ingredient Chlorpheniramine. It is an antihistamine, most commonly used to treat allergy symptoms. Common side effects of this drug include: -drowsiness -dry mouth, nose, and throat -nausea -vomiting -l
Human subcutaneous white adipose tissue (SC WAT) increases the expression of beige adipocyte genes in the winter. Studies in rodents suggest that a number of immune mediators are important in the beiging response. Here we studied the seasonal beiging response in SC WAT from lean humans. We measured the gene expression of various immune cell markers and performed multivariate analysis of the gene expression data to identify genes that predict UCP1. IL4 and, unexpectedly, the mast cell marker CPA3 predicted UCP1 gene expression. We therefore investigated the effects of mast cells on UCP1 induction by adipocytes. TIB64 mast cells responded to cold by releasing histamine and IL4, and this medium stimulated UCP1 expression and lipolysis by 3T3-L1 adipocytes. Pharmacological block of mast cell degranulation potently inhibited histamine release by mast cells and inhibited adipocyte UCP1 mRNA induction by conditioned medium. Consistent with this, the histamine receptor antagonist chlorpheniramine ...
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Replied on 04/19/2011 Sudafed contains pseudoephedrine which has a very narrow margin of safety in cats. This means that the effective dose is very close to the toxic dose. I would not recommend its use in cats at all. Its just not worth the risk. The discharge in his nose is likely from his runny eye draining into his nose. Has your cat been to see his veterinarian and is he on medication for his eye infection? If so the discharge should be resolving soon and you shouldnt need to medicate him. If it seems to be lingering it may be this is all related to an upper respiratory infection and using an antihistamine may help. You can give him Benadryl (diphenhydramine) at 1mg per pound two to three times daily OR Chlorpheniramine at 2mg to 4mg per cat twice daily. Antihistamines can make cats hyper or drowsy so watch for side effects.. ...
Diominic Dca Tablet is used for common cold, cold, fever, allergy, sore throat, ear pain and other conditions. Diominic Dca Tablet contains the following active ingredients: Caffeine, Chlorpheniramine, Paracetamol, and Phenylephrine.
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Be sure to mention any of the following: alprazolam (Xanax); anticoagulants (blood thinners) such as warfarin (Coumadin); aripiprazole (Abilify); buspirone (Buspar); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan); chlorpheniramine; cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); diazepam (Valium); erythromycin (E ...
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In the present study, we have shown that both cetirizine 10 mg and chlorpheniramine 4 mg increased P300 latencies significantly compared with baseline. Only been a few studies have examined the effect of antihistamines on P300 latency in children.24,25 None, to our knowledge, has studied the sedative effect of cetirizine in atopic children using P300 latency. Compared with many other objective tests of CNS function, it has the advantages of being relatively simple; rapid; and less affected by practice, motivation, or boredom.20,21 It is an objective measure that is suitable for use in children and that has been used extensively to study the cognitive effects of antihistamines and other medication.21 Prolongation of P300 latency is taken as an index of impaired cognitive function.6. The inclusion of chlorpheniramine as the positive control in our study was not to draw direct comparisons with cetirizine but to ensure sensitivity.6 Chlorpheniramine 4 mg has been shown to increase P300 latency ...
Houston, TX (SafetyAlerts) - The Food and Drug Administration (FDA) today reported that Great Southern Laboratories (GSL) is recalling Cyndal HD Cough Syrup because of subpotency of the phenylephrine (50%) due to incorrect weight addition in batch production. The recalled Cyndal HD Cough Syrup (Hydrocodone Bitartrate 1.57mg/ Phenylephrine Hydrochloride 5mg/Chlorpheniramine Maleate 2mg), was sold in 16 fluid ounce (NDC 60258-703-16) and 1 gallon (NDC 60258-703-28) containers. According to FDA, 118 gallon bottles and 7,032 pint bottles were distributed in the Southeastern United States.. The recalled vials can be identified by the Lot Number 91949.. This ongoing Class III recall was initiated by GSL by verbal communication on December 15, 1999, followed by letters dated December 21 and 30, 1999. This is the first public notice issued by the FDA.. Questions concerning this recall may be directed to the FDA at 1-888-INFO-FDA ...
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best methods of treatment of allergic rhinitis, that is the most usual, is the usage of classic antihistaminic drugs [such asChlorpheniramine], but their side effects, specially somnolence and malaise, made a few patients to discontinue such treatment. More than a decade has showed that the Non Sedating Anti Histaminic Drugs [Terfenadin, Astemizole andLoratadine] are free from these side effects and do not show the CNS and anticholinergic disorders. The evaluation of their efficacy in the epidemiology of IRAN, beside the comparison of generic products with the registrated ones, is the main goal of this research. In this clinical study, the efficacy and adverse reactions of the Loratadine and its registratedproduct called Claritin are compared with Chlorpheniramine on 90 patients. It has been performed in northeast IRANand the study is a kind of double blind, prospective studies.30 patients have received Chlorpheniramine, as the same for Loratadine and Claritin. Then the results are compared with ...
TY - JOUR. T1 - High-affinity binding of [3H]doxepin to histamine H1-receptors in rat brain. T2 - Possible identification of a subclass of histamine H1-receptors. AU - Taylor, John E.. AU - Richelson, Elliott. PY - 1982/3/12. Y1 - 1982/3/12. N2 - The binding of the radioactively labeled tricyclic antidepressant, [3H]doxepin, to rat brain tissie was examined. Scatchard plots of specific [3H]doxepin binding indicated the presence of two distinct binding sites. The equilibrium dissociation constant (KD) of the high-affinity site was 0.020 nM with a maximal binding capacity (Bmax) of 13.7 fmol/mg protein. The corresponding values for the low-affinity site were 3.6 nM and 740 fmol/mg protein, respectively. The high-affinity site was sensitive to competition by pharmacologically relevant concentrations of histamine H1 antagonists such as pyrilamine (KD = 1.0 nM), diphenhydramine (KD = 20 nM), d-chlorpheniramine (KD = 1.7 nM), and 1-chlorpheniramine (KD = 97 nM). The Bmax for [3H]doxepin binding in the ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
What is Poly-Tussin (Chlorpheniramine/Hydrocodone/Phenylephrine)? Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Hydrocodone is a narcotic. It is a pain reliever and a … Read more →. ...
Manufacturer of Pharmaceutical Syrups - Terbutaline Sulphate Bromhexine HCL Guaiphenesin And Menthol Syrup, Iron Tonic With Vitamin Syrup, Dextromethorphan Hydrobromide Phenylephrine hydrochloride And Chlorpheniramine Maleate Syrup and Ferrous Ascorbate And Folic Suspension offered by Skylla Pharmaceuticals, Panchkula, Haryana.
Health Canada says it will require relabeling of all over-the-counter cough and cold medicines sold in Canada for use in children under the age of 12.. Officials said the new labels must indicate the medications should not be used in children under 6 years old. The products affected are those containing any active ingredients that are given orally:. --Antihistamines: brompheniramine maleate, chlorpheniramine maleate, clemastine hydrogen fumerate, dexbrompheniramine maleate, diphenhydramine hydrochloride, doxylamine succinate, pheniramine maleate, phenyltoloxamine citrate, promethazine hydrochloride, pyrilamine maleate and triprolidine hydrochloride.. --Antitussives: dextromethorphan, dextromethorphan hydrobromide or diphenhydramine hydrochloride.. --Expectorants: guaifenesin (glyceryl guaiacolate).. --Decongestants: ephedrine hydrochloride/sulphate, phenylephrine hydrochloride/sulphate or pseudoephedrine hydrochloride/sulphate.. Health Canada said the relabeling of the medications will be ...
For combination products (mixtures), the names of the active ingredients should be provided. The proprietary name of the combination may be given in parentheses if necessary to clarify the product to which the article refers.pseudoephedrine hydrochloride and triprolidine hydrochloride (Actifed) povidone and hydroxyethylcellulose (Adsorbotear) If the list of active ingredients is too long to use when referring to the combination product, the active ingredients should be listed at first mention and either an abbreviation or the proprietary name used thereafter.The patient reported having taken several doses of Vanex HD, a liquid suspension of hydrocodone bitartrate, 10 mg, phenylephrine hydrochloride, 30
Finding an increased risk of dementia and Alzheimers with so many common over-the-counter medications such as Benadryl and Chlortrimeton (the first generation allergy drug that so many people took for years) was an unpleasant surprise. Note: they found the link with high doses or heavy use (3 or more years). Some examples of common anticholinergics (from Wikipedia) are: atropine, benztropine (Cogentin), chlorpheniramine (Chlor-Trimeton), dimenhydrinate (Dramamine), diphenhydramine (Benadryl, Sominex, Advil PM, etc.), doxylamine (Unisom), hydroxyzine (Atarax, Vistaril), ipratropium (Atrovent), oxybutynin (Ditropan, Driptane, Lyrinel XL), tolterodine (Detrol, Detrusitol), tiotropium (Spiriva), and bupropion (Zyban, Wellbutrin). The message here: only take medications when absolutely needed and for as little a time as necessary. The study was done on older adults, so now the question is: what about children or young adults who take these drugs for years? Is there a similar increased risk later in ...
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Just a note on the mechanism of brain fog. Diphenhydramine is a non-selective histamine receptor antagonist - it blocks histamine receptors. Newer second-generation antihistamines, in contrast to diphenhydramine, do not easily pass the blood brain barrier (BBB). The BBB is created by astrocyte (support cells in the brain that are not actually neurons, or brain cells that can fire in the same way that neurons can) foot processes that line the blood vessels of the brain, enabling selectivity of what actually enters the tissue of the brain. After crossing the BBB, diphenhydramine blocks histamine receptors, most importantly those in the cerebral cortex. Histamine is actually produced in the hypothalamus and released in the cortex as one of the many overlapping systems that maintains wakefulness. So, blockade of these receptors makes you feel sleepy ...

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Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ... What other drugs will affect aspirin, chlorpheniramine, and phenylephrine?. Ask your doctor before using this medicine if you ... What is aspirin, chlorpheniramine, and phenylephrine?. Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It ... Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ...
more infohttps://www.rexhealth.com/app/healthwise/document.aspx?id=d06976a1

chlorpheniramine - Adventist HealthCarechlorpheniramine - Adventist HealthCare

Chlorpheniramine is used to treat runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the ... Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ... What is chlorpheniramine?. Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the ... What should I discuss with my healthcare provider before taking chlorpheniramine?. You should not use chlorpheniramine if you ...
more infohttps://www.adventisthealthcare.com/health/library/topic/?id=d00191a1

chlorpheniramine | PeaceHealthchlorpheniramine | PeaceHealth

Chlorpheniramine is used to treat runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the ... Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ... What is chlorpheniramine?. Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the ... What should I discuss with my healthcare provider before taking chlorpheniramine?. You should not use chlorpheniramine if you ...
more infohttps://www.peacehealth.org/medical-topics/content/multum/d00191a1.html

chlorpheniramine, methscopolamine, and pseudoephedrine | Cignachlorpheniramine, methscopolamine, and pseudoephedrine | Cigna

Chlorpheniramine and methscopolamine are antihistamines that reduce the effects of natural chemical histamine in the body. ... What is chlorpheniramine, methscopolamine, and pseudoephedrine?. Chlorpheniramine and methscopolamine are antihistamines that ... chlorpheniramine, methscopolamine, and pseudoephedrine. Skip to the navigation Pronunciation: KLOR fen IR a meen, METH skoe POL ... What is the most important information I should know about chlorpheniramine, methscopolamine, and pseudoephedrine?. Do not use ...
more infohttps://www.cigna.com/individuals-families/health-wellness/hw/medications/chlorpheniramine-methscopolamine-and-d03911a1

chlorpheniramine, dextromethorphan, and phenylephrine | Cignachlorpheniramine, dextromethorphan, and phenylephrine | Cigna

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ... What is chlorpheniramine, dextromethorphan, and phenylephrine?. Chlorpheniramine is an antihistamine that reduces the effects ... Do not use chlorpheniramine, dextromethorphan, and phenylephrine if you have taken an MAO inhibitor in the past 14 days. A ... chlorpheniramine, dextromethorphan, and phenylephrine. Skip to the navigation Pronunciation: klor feh NEER a meen, dex troe meh ...
more infohttps://www.cigna.com/individuals-families/health-wellness/hw/medications/chlorpheniramine-dextromethorphan-and-d03369a1

Chlorpheniramine-phenylephrine: uses & side-effects | PatientsLikeMeChlorpheniramine-phenylephrine: uses & side-effects | PatientsLikeMe

Find the most comprehensive real-world treatment information on Chlorpheniramine-phenylephrine at PatientsLikeMe. 2 patients ... bipolar I disorder or psoriasis currently take Chlorpheniramine-phenylephrine. ...
more infohttps://www.patientslikeme.com/treatment/12551-actifed-cold-and-allergy-side-effects-and-efficacy

Chlorpheniramine-phenylephrine: uses & side-effects | PatientsLikeMeChlorpheniramine-phenylephrine: uses & side-effects | PatientsLikeMe

Find the most comprehensive real-world treatment information on Chlorpheniramine-phenylephrine at PatientsLikeMe. 2 patients ... bipolar I disorder or psoriasis currently take Chlorpheniramine-phenylephrine. ...
more infohttps://www.patientslikeme.com/treatment/11558-ceron-side-effects-and-efficacy
  • Before you give a chlorpheniramine product to a child, check the package label to find out how much medication the child should receive. (medlineplus.gov)
  • If you become pregnant while taking chlorpheniramine, call your doctor. (medlineplus.gov)
  • Chlorpheniramine is used for reactions to vaccinations and blood transfusions, insect bites and stings, snakebites, to soothe itchy skin, and for a variety of other related purposes. (vetdepot.com)
  • Therefore, use of henbane with chlorpheniramine could increase the risk of anticholinergic side effects, though apparently no interactions have yet been reported. (adventisthealthcare.com)
  • We are a reliable entity, working with high precision in providing excellent quality Chlorpheniramine Suspension. (tradeindia.com)
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking chlorpheniramine. (medlineplus.gov)
  • Use chlorpheniramine/guaifenesin as directed by your doctor. (drugs.com)
  • Chlorpheniramine comes alone and in combination with fever and pain reducers, expectorants, cough suppressants, and decongestants. (medlineplus.gov)
  • Chlorpheniramine blocks the effects of histamine in the body. (vetdepot.com)
  • Although appropriate studies on the relationship of age to the effects of codeine and chlorpheniramine combination have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. (mayoclinic.org)
  • Torsades de pointes induced by concomitant use of chlorpheniramine and propranolol: An unusual presentation with no QT prolongation. (nih.gov)
  • Do not give chlorpheniramine products that are made for adults to children. (medlineplus.gov)
  • Some medical conditions may interact with chlorpheniramine/guaifenesin. (drugs.com)
  • If you are giving chlorpheniramine or a combination product that contains chlorpheniramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. (medlineplus.gov)