A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Compounds containing phenyl-1-butanone.
A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
A histamine H2 receptor antagonist that is used as an anti-ulcer agent.
Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.
Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.
A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
The hindering of output from the STOMACH into the SMALL INTESTINE. This obstruction may be of mechanical or functional origin such as EDEMA from PEPTIC ULCER; NEOPLASMS; FOREIGN BODIES; or AGING.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system. (1/137)

Transport characteristics of diphenhydramine, an antihistamine, were studied in cultured human intestinal Caco-2 cell monolayers to elucidate the mechanisms of its intestinal absorption. Diphenhydramine accumulation in the monolayers increased rapidly and was influenced by extracellular pH (pH 7.4 > 6.5 > 5.5). Diphenhydramine uptake was temperature dependent, saturable, and not potential sensitive. Kinetic analysis revealed that the apparent Km values were constant (0.8-1.0 mM) in all pH conditions tested, whereas Vmax values decreased at the lower pH. The initial uptake of diphenhydramine was competitively inhibited by another antihistamine, chlorpheniramine, with a Ki value of 1.3 mM. On the other hand, cimetidine and tetraethylammonium, typical substrates for the renal organic cation transport system, had no effect. Moreover, biological amines and neurotransmitters, such as histamine, dopamine, serotonin, and choline, also had no effect on the diphenhydramine accumulation. Finally, diphenhydramine uptake was stimulated by preloading monolayers with chlorpheniramine (trans-stimulation effect). These findings indicate that diphenhydramine transport in Caco-2 cells is mediated by a specific transport system. This pH-dependent transport system may contribute to the intestinal absorption of diphenhydramine.  (+info)

Nalpha-methyl histamine and histamine stimulate gastrin release from rabbit G-cells via histamine H2-receptors. (2/137)

BACKGROUND: Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin release. H. pylori is reported to produce Nalpha-methyl histamine (NalphaMH), which is an agonist of H3 as well as other histamine receptors. H. pylori infection also recruits mast cells, which release histamine. AIM: To determine the direct effects of histamine receptor agonists on isolated gastrin cells. METHODS: Rabbit G-cells were prepared by countercurrent elutriation and cultured on 24-well plates. RESULTS: NalphaMH (10-6-10-4 M) caused a dose-dependent increase in gastrin release from a basal level of 2.3 +/- 0.2% total cell content (TCC; mean +/- S.E.M.) to a maximum of 5.1 +/- 0.7%, an increase of 117% (P < 0. 005) above basal. This was abolished by the H2-antagonist ranitidine (10-5 M), but not by immunoblockade with anti-somatostatin antibody, the H1-antagonist chlorpheniramine (10-5 M) or the H3-antagonist thioperamide (10-4 M). The histamine H2-receptor agonist dimaprit (10-6-10-4 M) increased gastrin release from 2.4 +/- 0.2% to 3.6 +/- 0.2% TCC (P < 0.001). Gastrin release was also stimulated by histamine (10-7-10-4 M) from a basal value of 3.0 +/- 0.3% to 5.4 +/- 0.5% TCC (P < 0.001). This also was inhibited by ranitidine (10-5 M) (P < 0.01). CONCLUSION: NalphaMH and histamine release gastrin from G-cells via H2-receptors; this might contribute to H. pylori-associated hypergastrinaemia.  (+info)

Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. (3/137)

BACKGROUND AND OBJECTIVE: Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors. The association between chronic hepatitis C and progression to cirrhosis and hepatocellular carcinoma has been reported in about 20% and 5% of patients, respectively, within 20-30 years of infection. In adult patients, interferon has proved to be effective in decreasing the abnormal values of transaminases and the level of HCV viremia. Our purpose was to assess efficacy of and tolerance to interferon in a group of young patients who had acquired HCV infection during a period of chemotherapy. DESIGN AND METHODS: Interferon-a (IFN) was administered to 26 adolescents and young adults (13 males, age range 17-36 years; median age 24) with chronic hepatitis C, including 4 with hepatitis B virus co-infection, who had been treated for leukemia or solid tumor 5 to 19 years before joining this trial. Patients were treated with natural IFN alpha at a dose of 4 MU/m(2) thrice weekly for 12 months and followed up for another 6 months thereafter. RESULTS: Nine patients stopped treatment during the first 6 months because of side effects (2 cases) or lack of response. At the end of the trial, 8 (31%) cases had responded, with alanine amino-transferase normalization and clearance of hepatitis C virus (HCV) RNA. A sustained response was only documented in 15% of cases, however, irrespective of any hepatitis B virus co-infection. The 2 patients with HCV genotype 2 were both responders, whereas only 8% of those with genotype 1 responded. INTERPRETATION AND CONCLUSIONS: These data show that the efficacy of IFN in this series of young patients is similar to that reported for otherwise healthy adults with hepatitis C. Patients with genotype 2 are strong candidates for IFN treatment while other therapeutic strategies should be designed for patients with HCV genotype 1.  (+info)

Bronchial vasodilation evoked by increased lower airway osmolarity in dogs. (4/137)

Hyperosmotic saline solutions stimulate lower airway sensory nerves. To determine whether airway hyperosmolarity evokes neurally mediated changes in bronchial artery blood flow (Qbr), we measured the effect of injection of small volumes (1 ml) of hyperosmotic saline into a right lobar bronchus on Qbr of anesthetized, artificially ventilated dogs. In 14 dogs, hyperosmotic saline (1,200 and 2,400 mmol/l) increased Qbr by 58 +/- 12 (SE) and 118 +/- 12%, respectively, from a baseline of 8 +/- 2 ml/min. Qbr increased within 6-8 s of the injections, peaked at 20 s, and returned to control over 2-3 min. Isosmotic saline had minimal effects. In contrast, hyperosmotic saline decreased flow in an intercostal artery that did not supply the airways. The bronchial vasodilation was decreased by 72 +/- 11% after combined blockade of alpha-adrenoceptors and muscarinic cholinergic receptors and by 66 +/- 6% when the cervical vagus nerves were cooled to 0 degrees C. Blockade of H(1) and H(2) histamine receptors did not reduce the nonvagal response. We conclude that hyperosmolarity of the lower airways evokes bronchial vasodilation by both a centrally mediated reflex that includes cholinergic and adrenergic efferent pathways and by unidentified local mechanisms.  (+info)

Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine. (5/137)

Antihistamine induced cognitive decline was evaluated using positron emission tomography (PET) measurement of histamine H1 receptor (H1R) occupancy and regional cerebral blood flow (rCBF). Cognitive performance in attention-demanding task deteriorated dose-dependently and the effects were statistically significant after the treatment of 2 mg of d-chlorpheniramine. There was no significant change in subjective sleepiness in the same dose. The regional blockade of H1R was observed mainly in the frontal, temporal and anterior cingulate cortices, and the intravenous administration of d-chlorpheniramine as a therapeutic dose (2 mg) blocked over 60% of H1R in the frontal cortices. The results from activation study using visual discrimination tasks demonstrated that enhanced activity in the right prefrontal and anterior cingulate cortices as well as a decreased activity in the left temporal and frontal cortices and midbrain after the treatment of d-chlorpheniramine. There were no changes in global CBF for the subjects treated with 2 mg d-chlorpheniramine (pre; 44.8+/-3.3 ml dl(-1) min(-1) vs post; 44.4+/-4.7 ml dl(-1) min(-1)). The results indicated that the attention system of human brain could be altered by therapeutic doses of H1R antagonists. These findings provide the information as to the potential risk of antihistamines in our daily activities. British Journal of Pharmacology (2000) 129, 115 - 123  (+info)

Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. (6/137)

We investigated the effect of stimulation of H(1)-receptors with histamine on protein tyrosine phosphorylation levels in guinea-pig left atrium and evaluated the influences of tyrosine kinase inhibitors on the positive inotropic effect mediated by H(1)-receptors in this tissue. Histamine induced an increase in tyrosine phosphorylation in four main clusters of proteins with apparent molecular weights of 25, 35, 65 and 150 kDa. Tyrosine phosphorylation of these proteins attained a peak around 2 - 3 min following histamine stimulation and then declined to or below basal levels. Histamine-induced protein tyrosine phosphorylation was antagonized by the H(1)-receptor antagonists mepyramine (1 microM) and chlorpheniramine (1 microM), but not by the H(2)-receptor antagonist cimetidine (10 microM). The positive inotropic effect of histamine was depressed in a concentration-dependent manner by the tyrosine kinase inhibitors tyrphostin A25 (50 to 100 microM) and genistein (10 to 50 microM) but not by the inactive genistein analogue daidzein (50 microM). The positive inotropic effect of isoprenaline was unchanged by tyrphostin A25 and genistein. At a concentration of 1 microM histamine produced a dual-component positive inotropic response composed of an initial increasing phase and a second and late developing, greater positive inotropic phase. Treatment with tyrphostin A25 (100 microM) and genistein (50 microM), but not daidzein (50 microM), significantly attenuated the two components of the inotropic response, although genistein suppressed the initial component more markedly than the late component. We conclude that increased protein tyrosine phosphorylation may play an important role in initiating at least some part of the positive inotropic effect of H(1)-receptor stimulation in guinea-pig left atrium.  (+info)

Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats. (7/137)

The study was designed to determine the cardiovascular effects of histamine administered intracerebroventricularly (icv) in a rat model of volume-controlled haemorrhagic shock. The withdrawal of approximately 50% of total blood volume resulted in the death of all control saline icv treated animals within 30 min. Icv injection of histamine produced a prompt dose-dependent (0.1-100 nmol) and long-lasting (10-100 nmol) increase in mean arterial pressure (MAP), pulse pressure (PP) and heart rate (HR), with a 100% survival of 2h after treatment (100 nmol). The increase in MAP and HR after histamine administration in bled rats in comparison to the normovolaemic animals was 2.7-3.3- and 1.3-3.6-fold higher, respectively. Pretreatment with chlorpheniramine (50 nmol icv), H1 receptor antagonist, inhibited the increase in MAP, PP, HR and survival rate produced by histamine, while chlorpheniramine given alone had no effect. Neither ranitidine (50 nmol icv), H2 histamine receptor antagonist, nor thioperamide (50 nmol icv), H3 receptor blocker, influenced the histamine action, however, when given alone, both evoked the pressor effect with elongation of survival time. It can be concluded that histamine administered icv reverses the haemorrhagic shock conditions, and histamine H1 receptors are involved.  (+info)

Painless thyroiditis induced by the cessation of betamethasone. (8/137)

We describe the first reported case of painless thyroiditis induced by an abrupt cessation of betamethasone. A 53-year-old woman experienced transient thyrotoxicosis after the abrupt cessation of celestamine, a mixture of betamethasone and chlorpheniramine. Since neither TSH receptor- nor thyroid stimulating-antibodies were negative, and thyroid scintigram did not show the thyroid gland, she was diagnosed as having painless thyroiditis. Fourteen months after the onset of thyrotoxicosis, serum TSH was detectable without hypothyroidism. We speculate that reduction in betamethasone may be one of the triggers of painless thyroiditis.  (+info)

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Chlorpheniramine maleate is an antihistamine used in many prescription and over-the-counter drugs. This eMedTV segment discusses specific uses, explains how the medicine works, lists possible side effects to be aware of, and more.
Administration of drugs through skin has received great attention through the last decade. Hence this study aims to formulate an anti- histaminic drug - chlorpheniramine maleate (CPM) as transdermal patch using methyl cellulose - a bioadhesive polymer with dibutylphthalate (DBP) as plasticizer. Patches were prepared through solvent evaporation method, subjected for various evaluations including in vitro dissolution and in vitro permeation. The above evaluations of transdermal patches promises that CPM can be developed successfully as transdermal patches as an alternative route of administration fulfilling the objectives of this research work.
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First generation antihistaminic and alchylamine drug, with sedative effect. Its active isomer is Dexchlorfeniramine. Oral dosage every 4-6 hours Since the last update we have not found published data on its excretion in breast milk. No problems requiring medical attention have been observed in infants of mothers taking chlorpheniramine (Ito 1993, Paton 1985). Likely inhibition of lactation within the first weeks post delivery because anti-prolactin effect (WHO 2002, Messinis 1985). Short-term and low dose (2 mg one or twice-day) treatment is compatible with breastfeeding (Lactmed 2017). Follow-up for sedation and feeding ability of the infant (Butler 2014, WHO 2002). For long-term treatment an alternative drug should be preferred (Powell 2007). Compounds in association with expectorants, corticoids and cough relief medicines are available. Avoid drug associations especially while breastfeeding. Bed-sharing is not recommended for mothers who are taking this medication (UNICEF
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Abstract: The method of choice for analysis of drugs in multi-component preparations is chromatographic based technique such as High Performance Liquid Chromatography (HPLC). However, chromatographic method is time consuming and requiring much effort. As a consequence, some simple methods such as UV spectrophotometry are continuously developed, especially in combination with the chemometrics software. The UV-vis spectrophotometry coupled with multivariate calibration of Partial Least Square (PLS) has been developed for quantitative analysis of paracetamol, guaiphenesin and chlopheniramine maleate in the presence of phenylpropanolamine without separation step. The calibration model is prepared by developing a series of sample mixture comprising these drugs in certain proportion. The evaluation of calibration model was based on coefficient of determination (R2) and Root Mean Square Error of Calibration (RMSEC). The result showed that UV spectrophotometry combined with PLS can be used for ...
Warfarin Sodium: Warfarin Sodium Amorphous: Warfarin Sodium Clathrate: X: Xanthan: Xantinol Nicotinate: Xipamide: Xylazine HCL: Xylitol. Shake well before using Learn about drug interactions between amitriptyline-chlordiazepoxide oral and methscopolamine oral and use the RxList drug interaction checker to check drug combinations The study is based on chlorpheniramine maleate and hydroxychloroquine sulfate (the active ingredients of Chlorpheniramine maleate and Hydroxychloroquine sulfate, respectively), and Chlorpheniramine maleate and Hydroxychloroquine sulfate (the brand names). Sanoski. Methylcobalamin 250mcg + Folic Acid 500mcg/5ml Syrup 19. It lists the capsules and tablets that are official in the United States Pharmacopeia and indicates the relevant tight (T), well-closed (W), and light-resistant (LR. 238. 172. Chlordiazepoxide / methscopolamine alcohol/food interactions. A to Z drug monographs from Facts & Comparisons; includes additional patient education materials and drug interactions. ...
In the present study, we have shown that both cetirizine 10 mg and chlorpheniramine 4 mg increased P300 latencies significantly compared with baseline. Only been a few studies have examined the effect of antihistamines on P300 latency in children.24,25 None, to our knowledge, has studied the sedative effect of cetirizine in atopic children using P300 latency. Compared with many other objective tests of CNS function, it has the advantages of being relatively simple; rapid; and less affected by practice, motivation, or boredom.20,21 It is an objective measure that is suitable for use in children and that has been used extensively to study the cognitive effects of antihistamines and other medication.21 Prolongation of P300 latency is taken as an index of impaired cognitive function.6. The inclusion of chlorpheniramine as the positive control in our study was not to draw direct comparisons with cetirizine but to ensure sensitivity.6 Chlorpheniramine 4 mg has been shown to increase P300 latency ...
ATHENE CHEMICALS PVT. LTD. - Distributor, Supplier, Trading Company, Wholesaler & Dealer of Paracetamol, Phenylephrine Hydrochloride& Cetirizine Hydrochloride Tab based in Ahmedabad, Gujarat. We provide best quality Product such as Paracetamol, Phenylephrine Hydrochloride& Cetirizine Hydrochloride Tab in all over India.
Houston, TX (SafetyAlerts) - The Food and Drug Administration (FDA) today reported that Great Southern Laboratories (GSL) is recalling Cyndal HD Cough Syrup because of subpotency of the phenylephrine (50%) due to incorrect weight addition in batch production. The recalled Cyndal HD Cough Syrup (Hydrocodone Bitartrate 1.57mg/ Phenylephrine Hydrochloride 5mg/Chlorpheniramine Maleate 2mg), was sold in 16 fluid ounce (NDC 60258-703-16) and 1 gallon (NDC 60258-703-28) containers. According to FDA, 118 gallon bottles and 7,032 pint bottles were distributed in the Southeastern United States.. The recalled vials can be identified by the Lot Number 91949.. This ongoing Class III recall was initiated by GSL by verbal communication on December 15, 1999, followed by letters dated December 21 and 30, 1999. This is the first public notice issued by the FDA.. Questions concerning this recall may be directed to the FDA at 1-888-INFO-FDA ...
Manufacturer of ANTI COLD TABLET - Ambroxol HCL 30mg Guaiphensin 50mg Levosulbutamol 1mg syrup, Dextromethorphan Hbr 10mg Phenylephrine Hbr 5mg Chlorpheniramine Maleate 5mg Menthol 1mg, Levocetirizine Dihydrochloride 5mg and Montelukast Sodium 10mg Levocetrizine 5mg offered by SNU Biocare, Panchkula, Haryana.
Manufacturer of COUGH SYRUP - HONITASK Cough Syrup, Ambroxol HCL Terbutaline Sulphate Syrup, Dextromethorphan HBR,Phenylephrine HCL & Chlorpheniramine Maleate Syrup offered by Alcolabs, Panchkula, Haryana.
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best methods of treatment of allergic rhinitis, that is the most usual, is the usage of classic antihistaminic drugs [such asChlorpheniramine], but their side effects, specially somnolence and malaise, made a few patients to discontinue such treatment. More than a decade has showed that the Non Sedating Anti Histaminic Drugs [Terfenadin, Astemizole andLoratadine] are free from these side effects and do not show the CNS and anticholinergic disorders. The evaluation of their efficacy in the epidemiology of IRAN, beside the comparison of generic products with the registrated ones, is the main goal of this research. In this clinical study, the efficacy and adverse reactions of the Loratadine and its registratedproduct called Claritin are compared with Chlorpheniramine on 90 patients. It has been performed in northeast IRANand the study is a kind of double blind, prospective studies.30 patients have received Chlorpheniramine, as the same for Loratadine and Claritin. Then the results are compared with ...
Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.. Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much ...
TY - JOUR. T1 - High-affinity binding of [3H]doxepin to histamine H1-receptors in rat brain. T2 - Possible identification of a subclass of histamine H1-receptors. AU - Taylor, John E.. AU - Richelson, Elliott. PY - 1982/3/12. Y1 - 1982/3/12. N2 - The binding of the radioactively labeled tricyclic antidepressant, [3H]doxepin, to rat brain tissie was examined. Scatchard plots of specific [3H]doxepin binding indicated the presence of two distinct binding sites. The equilibrium dissociation constant (KD) of the high-affinity site was 0.020 nM with a maximal binding capacity (Bmax) of 13.7 fmol/mg protein. The corresponding values for the low-affinity site were 3.6 nM and 740 fmol/mg protein, respectively. The high-affinity site was sensitive to competition by pharmacologically relevant concentrations of histamine H1 antagonists such as pyrilamine (KD = 1.0 nM), diphenhydramine (KD = 20 nM), d-chlorpheniramine (KD = 1.7 nM), and 1-chlorpheniramine (KD = 97 nM). The Bmax for [3H]doxepin binding in the ...
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
What is Poly-Tussin (Chlorpheniramine/Hydrocodone/Phenylephrine)? Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Hydrocodone is a narcotic. It is a pain reliever and a … Read more →. ...
To evaluate just how much exposure the participants had to anticholinergic drugs, the researchers used computer records in the drugstores that dispensed them.. From the drugstore data the participants added up all of the normal daily doses and worked out the accumulative anticholinergic vulnerability for every participant within the previous 10 years.. Within the length of the research, almost 800 participants developed dementia.. The outcomes revealed the most frequently used drugs were tricyclic antidepressants ( for instance, doxepin or Sinequan), first-generation antihistamines (chlorpheniramine, Chlor Trimeton), and antimuscarinics for bladder management (oxybutynin, Ditropan).. The researchers estimated that individuals taking at least 10 milligrams daily of doxepin, 4 milligrams per day of chlorpheniramine, or 5 milligrams daily of oxybutynin for at least three years would be at greater danger of developing dementia.. But while there are very few options to oxybutynin for increasing ...
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This study evaluate the efficacy and safety of experimental drug The study was designed to evaluate the efficacy and safety of fixed combinations Decongex® Plus Syrup and Decongex® Plus Oral Solution (consisting of brompheniramine maleate and phenylephrine hydrochloride) compared to Resfenol® Oral Solution (paracetamol, maleate chlorpheniramine and phenylephrine hydrochloride) in the treatment of nasal congestion and rhinorrhea present in acute attacks of viral rhinitis (common cold) and allergic. This study population will consist in participants of both sexes, aged between 6 to 11 years old with acute inflammatory condition of the upper airways, defined as nasal congestion and runny nose, with no less than 24 (twenty four) hours and a maximum of 48 (forty-eight) hours prior to inclusion ...
This study evaluate the efficacy and safety of experimental drug The study was designed to evaluate the efficacy and safety of fixed combinations Decongex® Plus Syrup and Decongex® Plus Oral Solution (consisting of brompheniramine maleate and phenylephrine hydrochloride) compared to Resfenol® Oral Solution (paracetamol, maleate chlorpheniramine and phenylephrine hydrochloride) in the treatment of nasal congestion and rhinorrhea present in acute attacks of viral rhinitis (common cold) and allergic. This study population will consist in participants of both sexes, aged between 6 to 11 years old with acute inflammatory condition of the upper airways, defined as nasal congestion and runny nose, with no less than 24 (twenty four) hours and a maximum of 48 (forty-eight) hours prior to inclusion ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
This study aimed at validating an analytical method, using the accuracy profile approach, for the assay of chlorphenamine maleate by capillary electrophoresis. The validation was done using concentrations ranging between 75% and 125% of the target concentration of 600 mg/ml. Validation standards were prepared separately in triplicate for each series. Studied validation criteria were selectivity, linearity, trueness, precision (repeatability and intermediate precision), accuracy and limits of detection and quantification. The method was selective, with recoveries ranging between 99.55% and 99.84%. The relative standard deviations of repeatability and intermediate precision were <5%. The accuracy profile confirmed the performance of the assay method between 75% and 100% of the target concentration of 600 mg/ml. The detection and quantification limits were 5 mg/l and 15 mg/l respectively. This ecological and economical method was applied to identify and quantify chlorphenamine maleate in 3 samples of
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose ...
Foeniculum vulgare (fennel) has been widely used in traditional medicine for treatment of variousdiseases including pediatric colic. This study was designed to assess the antinociceptive effects of aqueousextract of F. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic andhistaminergic systems. The results of this study showed that aqueous extract of F. vulgare (50, 100 and 200mg/kg, IP) induces antinociceptive effects (Pcimetidine significantly attenuate this effect (from 71.9% to 21.6%, PP=0.003, respectively). Furthermore, chlorpheniramine and cimetidine significantly decreased onset of first abdominal writhing (latency) in comparison with extract (Pphentolamine had no effect on antinociception and the latency induced by F. vulgare. The ED50 value for antinociceptive effects of extract was 87.6 mg/kg. These results suggest that antinociceptive effects of F. vulgare are partially mediated by histamine H1 and H2 receptors.
You may use medicine daily for quick relief of symptoms that occur suddenly or are getting worse. Or you may use it in advance if you know you may breathe an allergen. For example, if you have severe pollen allergies, your doctor may suggest that you start using a corticosteroid spray 1 to 2 weeks before the pollen season starts.. You may want to think about using different medicines at different times of the day. For example, during the day you could use a nondrowsy antihistamine such as fexofenadine (such as Allegra) or loratadine (such as Claritin). But if you are at home in the evening and sleepiness is not a concern, you can think about using an antihistamine like diphenhydramine (Benadryl) or chlorpheniramine (Chlor-Trimeton). These are less expensive but can make you feel sleepy. You may also try a combination of medicines to relieve all of your symptoms. Talk with your doctor about which symptoms are most important for you to treat and which medicines may work best for you. For worse ...
Histamine, norepinephrine and KCl each evoke contractile responses in isolated guinea-pig mesenteric artery. However, only the contractile response to histamine was characterized by acute desensitization or tachyphylaxis. The tachyphylaxis observed to histamine was independent of the time interval between successive administrations up to at least 1 hr. The histamine H1-receptor blocker, chlorpheniramine (10(-9) M), completely inhibited contractile responses to histamine (10(-5) M). In contrast, metiamide (10(-4) M), an H2-receptor blocker, potentiated contractions which were characterized by tachyphylaxis. Propranolol (10(-6) M), phentolamine (10(-6) M) and atropine (10(-6) M) affected neither the contractile response itself nor the tachyphylaxis to histamine (10(-5) M). Indomethacin (10(-5) M) and aspirin (3 X 10(-4) M) potentiated the initial contraction induced by histamine (10(-5) M) and completely abolished the tachyphylaxis. The response to the initial application of histamine (10(-5) M) ...
Q: I am pregnant and need something for a cold. What can I take?. A: There are several OTC options that have various combinations of the recommended drugs to use in pregnancy. Find one that correlates with the symptoms you are experiencing and try not to use anything with extra medications you do not need. The best options for several common problems are:. Pain/fever: Acetaminophen (Tylenol®). Cough: Dextromethorphan. Nasal congestion: Phenylephrine (Sudafed®). Antihistamine: Chlorpheniramine. Chest congestion: Guaifenesin. Overall, a lot of OTC medications can be taken safely, but it is definitely best to only use them short term. Be sure to also always check with your OB-GYN or pharmacist before starting a new medication.. This question was answered by pharmacy student, Will Stevens.. Disclaimer: Answers to inquiries concerning information about health conditions and/or medications are not for diagnostic or treatment purposes and can not be considered conclusive without consulting with a ...
BREMERTON, WASHINGTON--A county coroner has changed the cause of Kristina Shannons death from acute overdose to undetermined after independent experts reviewed the case and the state of Washington threatened to take him to court. Kitsap County Coroner Greg Sandstrom had originally accepted the opinion of forensic pathologist Emmanuel Lacsina, that Shannon, 29, had 5 1/2 times the normal amount of the antihistamine chlorpheniramine in her system when she suddenly died on July 2, 2005. Her father, Denny Shannon, said his daughter had autism and intellectual disabilities, and could not have taken the drug on her own. Officials with the Department of Social and Health Services objected to the Sandstroms initial ruling and ordered a separate investigation, saying that the coroners report did not match medical records kept by staff at Frances Haddon Morgan Center, the institution where Shannon had stayed for 20 years. They hired outside consultants who investigated Shannons death and reportedly ...
The anti-epileptic drug Keppra® (levetiracetam) reached net sales of EUR 460 million which is 1% lower than last year due to further post-patent expiry erosion in North America (-21%) and the divestment of smaller emerging markets to GlaxoSmithKline (GSK) in the first quarter of 2009 which was compensated by extended market leadership in Europe (+12%) and an increase of 4% in Rest of World. Zyrtec® (cetirizine), for allergy, had reduced net sales of 12% to EUR 150 million due to the divestment to GSK. European sales remained stable, whilst Japanese sales increased by 4% through the successful launch of paediatric indications and new formulations. Xyzal® (levocetirizine), for allergy, reached net sales of EUR 63 million (-23%) following entry of generic competition in the European market. Tussionex™ (hydrocodone polistirex and chlorpheniramine polistirex) made net sales of EUR 45 million (-33%) after a market shift to codeine-based products combined with a weak cough and cold season in the ...
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DM COUGH AND COLD LIQUID CHERRY FLAVOUR is a specialty drug on the Reformulary and can be used to treat . Check with your doctor if there are other medications you can take before taking this drug.
3.0.co;2-5. Carter, S. J.; Cassaday, H. J. (1998). "State-Dependent Retrieval and Chlorpheniramine". Human ...
... is an analog of chlorpheniramine. The only difference is that the chlorine atom in the benzene ring is replaced ... chlorpheniramine, dexchlorpheniramine (Polaramine), triprolidine (Actifed), and iodopheniramine. The halogenated alkylamine ...
Chlorpheniramine was patented in 1948 and came into medical use in 1949. It is available as a generic medication and over the ... Chlorphenamine is the INN while chlorpheniramine is the USAN and former BAN. Brand names have included Demazin, Allerest 12 ... "Chlorpheniramine Maleate, Dexchlorpheniramine Maleate Monograph for Professionals". Drugs.com. American Society of Health- ... Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions ...
Active ingredients include dextromethorphan, pseudoephedrine and chlorpheniramine. The combination of antihistamine, de- ...
Coricidin, Coricidin D, or Coricidin HBP, is the brand name of a combination of dextromethorphan and chlorpheniramine maleate ( ... Examples are diphenhydramine, chlorpheniramine, brompheniramine, loratadine, and cetirizine. Decongestants may improve nasal ...
Benztropine Benzydamine Chlorpheniramine Singh A. Herbalism, Phytochemistry and Ethnopharmacology. Science Publishers. p. 45. ...
It is the pharmacologically active dextrorotatory isomer of chlorpheniramine. It came into medical use in 1959 and was patented ...
Its active ingredients are chlorpheniramine maleate and codeine phosphate. Chlorpheniramine maleate, an H1-blocking ...
Double-blind comparative study of treatment with cyproheptadine, chlorpheniramine, and placebo". Arch Dermatol. 113 (10): 1375- ...
... cetirizine and chlorpheniramine. They do not prevent the discharge of histamine, but it has been proven that they do prevent a ...
Antihistamines such as diphenhydramine and chlorpheniramine are commonly used as treatment. People treated with H1 ...
It is also able to transform the antihistamines brompheniramine, chlorpheniramine and pheniramine. It forms a glucoside with ... chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans". Xenobiotica ...
A form that contains dextromethorphan, pseudoephedrine, acetaminophen, and chlorpheniramine, is sold as Cotylenol. As of 2021[ ... chlorpheniramine and phenylephrine. The brand was introduced in 1955 by McNeil Laboratories, a family-owned pharmaceutical ...
Parasympathetic stimulation, e.g. bethanechol, pilocarpine, carbachol Antihistamines e.g. chlorpheniramine, diphenhydramine, ...
... comparison with chlorpheniramine and immepip". Pharmacology, Biochemistry, and Behavior. 79 (1): 119-124. doi:10.1016/j.pbb. ...
... is also present in various cough syrups as codeine phosphate including chlorpheniramine maleate. Pure codeine is also ...
... hydrocodone polistirex/chlorpheniramine). However, it is noted that opioid/antihistamine combinations are used clinically for ... Atropine Benztropine Biperiden Chlorpheniramine Certain SSRIs (Paroxetine) Dicyclomine (Dicycloverine) Dimenhydrinate ...
"Factitious Urticaria (dermographism): Treatment by Cimetidine and Chlorpheniramine in a Randomized Double-blind Study." Br J ...
Yasuda SU, Yasuda RP (1999). "Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic ...
First generation antihistamines include diphenhydramine (Benadryl), chlorpheniramine (Diabetic Tussin), hydroxizine (Atarax), ...
Short courses of sedative antihistamines such as chlorpheniramine may be useful in alleviating the itch. Fever during treatment ...
These included "elevated levels" of hydrocodone, acetaminophen, L-methamphetamine, and chlorpheniramine, all of which are legal ...
... phenylephrine and chlorpheniramine in pharmaceutical formulations: capsules and sachets". Journal of Pharmaceutical and ...
First-generation antihistamines such as chlorpheniramine and clemastine are more potent but have greater sedatory effects; ...
His autopsy found alprazolam, diazepam, bupropion, citalopram, hydrocodone, digoxin, chlorpheniramine, methamphetamine, and ...
Common/marketed: Brompheniramine (Dimetapp, Dimetane) Chlorpheniramine (Chlor-Trimeton) Dimenhydrinate (Dramamine, Gravol) - ... chlorpheniramine (Chlor-Trimeton), and brompheniramine (Dimetane). However, a 1955 study of "antihistaminic drugs for colds," ...
Multisymptom cold medicines contain other active ingredients, such as paracetamol (acetaminophen), chlorpheniramine, and ... this brand presents additional danger when used at recreational doses due to the presence of chlorpheniramine. In over-the- ...
Both products contained chlorpheniramine maleate (an antihistamine) and phenylpropanolamine hydrochloride (a decongestant) but ... Both products contained 75 mg of phenylpropanolamine hydrochloride, but Cold Capsule IV contained 12 mg chlorpheniramine ...
Sometimes a third active ingredient, such as ascorbic acid, caffeine, chlorpheniramine maleate, or guaifenesin is added to this ... and Chlorpheniramine Maleate in Pharmaceutical Dosage Forms". Journal of Chromatographic Science. 40 (2): 97-100. doi:10.1093/ ...
Post-crash toxicology tests found signs of chlorpheniramine, a sedating antihistamine, in the pilot's blood and urine. The ...
Chlorpheniramine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Chlorpheniramine is usually taken as needed. If your doctor has told you to take chlorpheniramine regularly, take the missed ... Before taking chlorpheniramine,. *tell your doctor and pharmacist if you are allergic to chlorpheniramine, any other ... If you are giving chlorpheniramine or a combination product that contains chlorpheniramine to a child, read the package label ...
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Chlorpheniramine is a first-generation agent that competes with histamine or H1-receptor sites on effector cells in blood ...
Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. ... Before taking chlorpheniramine, tell your doctor or pharmacist if you are allergic to it; or to dexchlorpheniramine; or if you ... Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms ... Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms ...
中文品名 縮水蘋果酸氯芬尼拉明錠 英文品名 Chlorpheniramine Maleate Tablets S.S.P. 主要成
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Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms.. Authors: ... Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms. ... A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropa-nolamine ...
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  • we are offering Phenylephrine Hydrochloride And Chlorpheniramine Maleate Syrup is utilized to treat manifestations of a hypersensitivity, cold, or sinus irritation. (kaps3.in)
  • Chlor-Trimeton (chlorpheniramine maleate) and Zyrtec (cetirizine hydrochloride) are antihistamines used to treat sneezing, itching, watery eyes, and runny nose caused by allergies or the common cold. (onteenstoday.com)
  • Chlorpheniramine is an antihistamine. (emedicinehealth.com)
  • Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. (blinkhealth.com)
  • Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. (paleymd.com)
  • Chlorpheniramine maleate (brand names: Chlor-Trimetron®, Aller-chlor®, Chlor-tripolon®, ChlorTabs ®) is an antihistamine used to treat allergic conditions and occasionally used as a mild sedative. (stonebridgevethospital.com)
  • Chlorpheniramine maleate is an antihistamine which may cause drowsiness. (northwestpharmacy.com)
  • Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets which are used in the treatment of common cold symptoms. (adenhealthcare.com)
  • Take a single dose of Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets three times a day for better results. (adenhealthcare.com)
  • Take these Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets daily or do not skip any of the doses for better results. (adenhealthcare.com)
  • Paracetamol, Caffeine, Phenylephrine and Chlorpheniramine Maleate Tablets rarely cause any kind of serious side effects. (adenhealthcare.com)
  • Manufacturer of a wide range of products which include dextromethorphan 10mg,phenylephrine 5mg, chlorpheniramine maleate 2mg (intocough syrup) and paracetamol 125mg, phenylepherine hydrochloride 2.5 mg & cpm syrup 1mg intogest. (integratedlaboratories.net)
  • Efficacy and Safety of a Fixed Dose Combination of Paracetamol, Chlorpheniramine Maleate, Phenylephrine and Caffeine in Treatment of Common Cold: A Phase IV, Open-Labelled, Multi-Centric Study. (aimdrjournal.com)
  • chlorpheniramine-pseudoeph-dextromethorph-acetaminophen oral decreases levels of tiludronate oral by reducing drug absorption from the stomach and intestine into the body when taken by mouth. (rxlist.com)
  • chlorpheniramine-pseudoeph-dextromethorph-acetaminophen oral decreases levels of tiludronate oral by inhibition of GI absorption. (rxlist.com)
  • What is acetaminophen / chlorpheniramine / dextromethorphan? (rxless.com)
  • When you get a acetaminophen-chlorpheniramine-dextromethorphan discount card for free from rxless, you'll pay the lowest possible price for your medication. (rxless.com)
  • To get started, check the section below for other drugs related to acetaminophen-chlorpheniramine-dextromethorphan. (rxless.com)
  • The next morning, she sought medical attention and was prescribed chlorpheniramine and acetaminophen. (cdc.gov)
  • Chlorpheniramine maleate is given by mouth in the form of a tablet, liquid syrup, or liquid drops. (stonebridgevethospital.com)
  • Our clients can avail this Hydrochloride And Chlorpheniramine Maleate Syrup at a practical cost. (kaps3.in)
  • Pioneers in the industry, we offer levodropropizine chlorpheniramine maleate syrup, simethicone 40mg , dill oil 0.005 ml and fennel oil 0.007 ml suspension, calcium ,vitamin d3 , methylcobalamin, l- methylfolate calcium & pyridoxal-5- phosphate tablets and terbutaline sulphate bromexine hydrochloride methenol syrup from India. (saphnixlifesciences.in)
  • Chlorpheniramine is available in 2 mg, 4 mg, 8 mg, 12 mg and 16 mg tablets and as a 2-mg/5 ml oral syrup. (petplace.com)
  • Coricidin II Cold & Flu contains 30 mg dextromethorphan Hydrobromide and 2 mg chlorpheniramine maleate and is available without a prescription from your doctor. (northwestpharmacy.com)
  • Are you currently using Chlorpheniramine-pseudoephedrine ER Oral? (webmd.com)
  • What is chlorpheniramine, dextromethorphan, and pseudoephedrine? (emedicinehealth.com)
  • Chlorpheniramine, dextromethorphan, and pseudoephedrine is a combination medicine used to treat cough , runny or stuffy nose, sneezing, itching, and watery eyes caused by allergies , the common cold , or the flu . (emedicinehealth.com)
  • Chlorpheniramine, dextromethorphan, and pseudoephedrine may also be used for purposes not listed in this medication guide. (emedicinehealth.com)
  • Do not use chlorpheniramine, dextromethorphan, and pseudoephedrine if you have used an MAO inhibitor in the past 14 days. (emedicinehealth.com)
  • IMSEAR at SEARO: Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms. (who.int)
  • A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropa-nolamine Hydrochloride (PPM) by first derivative UV spectrophotometry has been developed in combined pharmaceutical dosage forms. (who.int)
  • A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen) 3 2+ ] and peroxydisulphate (S 2 O 8 2- ) in the presence of light. (elsevier.com)
  • Increased ornithine decarboxylase activity induced in an is chemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. (xahnb.com)
  • Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. (xahnb.com)
  • The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate. (xahnb.com)
  • Chlorpheniramine maleate is a type of anti-histamine drug commonly used in dogs with allergies to control itching. (petplace.com)
  • In eight subjects, the administration of 10 mg chlorpheniramine intravenously increased the TD of histamine four times (the ratio of TD histamine chlorpheniramine/TD histamine was four), whereas in one subject, the same amount of chlorpheniramine exhibited a dose-ratio of 8 (Fig 2). (onlineasthmainhalers.com)
  • In one of these two subjects, 15 mg chlorpheniramine intravenously increased the TD to allergen twice (Fig 3) and the TD to histamine 8 times (Fig 2). (onlineasthmainhalers.com)
  • Influence of chlorpheniramine injected intravenously on threshold dose of inhaled histamine. (onlineasthmainhalers.com)
  • Chlorpheniramine competes with histamine or H1 receptor sites on effector cells in blood vessels and the respiratory tract. (medscape.com)
  • Chlorpheniramine Maleate is also known as antiallergic which helps in treating allergy symptoms like runny nose, watery eyes, and sneezing. (adenhealthcare.com)
  • tell your doctor and pharmacist if you are allergic to chlorpheniramine, any other medications, or any of the ingredients in the chlorpheniramine product you plan to use. (medlineplus.gov)
  • You should not use this medicine if you are allergic to chlorpheniramine, hydrocodone, or phenylephrine. (paleymd.com)
  • Chlorpheniramine maleate should not be used in pets that are allergic to it or other similar antihistamines. (stonebridgevethospital.com)
  • The objective of this open-label, randomized, two-period, crossover study was to evaluate the oral bioavailability of the Mallinckrodt extended release test capsule formulation of chlorpheniramine polistirex/hydrocodone polistirex compared to an equivalent oral dose of a commercially available extended release oral suspension of chlorpheniramine polistirex/hydrocodone polistirex (Tussionex® Pennkinetic® Extended Release Oral Suspension, Celltech Pharmaceuticals, Inc.) in a test group of healthy subjects under fasting conditions. (clinicaltrials.gov)
  • One of subjects with TD of H of 0.16 mg, was tested first with chlorpheniramine, 10 mg, and his TD of H increased to 0.64 mg-one of the closed circles at this dose level-and then with 15 mg chlorpheniramine. (onlineasthmainhalers.com)
  • Effect on threshold dose of allergen of dose of atropine having an anticholinergic activity similar to anticholinergic activity of 10 or 15 mg chlorpheniramine given intravenously. (onlineasthmainhalers.com)
  • Left panel: influence of intravenously given chlorpheniramine on threshold dose of acetylcholine. (onlineasthmainhalers.com)
  • Nonprescription cough and cold combination products, including products that contain chlorpheniramine, can cause serious side effects or death in young children. (medlineplus.gov)
  • Chlorpheniramine comes as a tablet, a capsule, an extended-release (long-acting) tablet and capsule, a chewable tablet, and a liquid to take by mouth. (medlineplus.gov)
  • The physicochemical characteristics of these spheroids were examined and compared against MCC-Ioaded alginate spheroids using chlorpheniramine maleate and tolbutamide as water-soluble and poorly water-soluble drugs respectively. (uitm.edu.my)
  • Chlorpheniramine Maleate + Levodropropizine is a combination of two medicines: Chlorpheniramine Maleate and Levodropropizine, which relieves dry cough . (saphnixlifesciences.in)
  • Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. (medlineplus.gov)
  • Do not give chlorpheniramine products that are made for adults to children. (medlineplus.gov)
  • Chlorpheniramine is in a class of medications called antihistamines. (medlineplus.gov)
  • The following medications should be used with caution when given with chlorpheniramine maleate: anticoagulants, MAOIs, phenytoin, or central nervous system depressants. (stonebridgevethospital.com)
  • Alcohol can make the side effects of chlorpheniramine worse. (medlineplus.gov)
  • Manus Aktteva Biopharma LLP is an ISO 9001:2015 Certified Global Supplier based in India for the product Chlorpheniramine maleate, 113-92-8. (manusaktteva.com)
  • If you are giving chlorpheniramine or a combination product that contains chlorpheniramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. (medlineplus.gov)
  • Before you give a chlorpheniramine product to a child, check the package label to find out how much medication the child should receive. (medlineplus.gov)
  • Chlorpheniramine, hydrocodone, and phenylephrine may also be used for purposes not listed in this medication guide. (paleymd.com)
  • If purchased over the counter, read the label carefully before giving this medication to ensure the product contains ONLY chlorpheniramine . (stonebridgevethospital.com)
  • We offer the product Chlorpheniramine maleate, 113-92-8 from our manufacturer / supplier / principals for your Research and Development / Evaluation or Commercial requirements, based on the product's availability from our network. (manusaktteva.com)
  • If you are looking for the API -Active Pharmaceutical Ingredients Chlorpheniramine maleate, 113-92-8 manufacturer supplier who is reliable and meets your required quality standard requirements in the first place, you are at the right place! (manusaktteva.com)
  • Chlorpheniramine is contraindicated in dogs with glaucoma, lung disease, heart disease, high blood pressure and prostate gland enlargement. (petplace.com)