Chlorphenesin
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Hyaluronic Acid
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A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
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Optimization of chlorphenesin emulgel formulation. (1/5)
This study was conducted to develop an emulgel formulation of chlorphenesin (CHL) using 2 types of gelling agents: hydroxypropylmethyl cellulose (HPMC) and Carbopol 934. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgels was investigated using a 2(3) factorial design. The prepared emulgels were evaluated for their physical appearance, rheological behavior, drug release, antifungal activity, and stability. Commercially available CHL topical powder was used for comparison. All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. They also exhibited higher drug release and antifungal activity than the CHL powder. It was found that the emulsifying agent concentration had the most pronounced effect on the drug release from the emulgels followed by the oil phase concentration and finally the type of the gelling agent. The drug release from all the emulgels was found to follow diffusion-controlled mechanism. Rheological studies revealed that the CHL emulgels exhibited a shear-thinning behavior with thixotropy. Stability studies showed that the physical appearance, rheological properties, drug release, and antifungal activity in all the prepared emulgels remained unchanged upon storage for 3 months. As a general conclusion, it was suggested that the CHL emulgel formulation prepared with HPMC with the oil phase concentration in its low level and emulsifying agent concentration in its high level was the formula of choice since it showed the highest drug release and antifungal activity. (+info)Production of chlorphenesin galactoside by whole cells of beta-galactosidase-containing Escherichia coli. (2/5)
We investigated the transgalactosylation reaction of chlorphenesin (CPN) using beta-galactosidase (beta-gal)-containing Escherichia coli (E. coli) cells, in which galactose from lactose was transferred to CPN. The optimal CPN concentration for CPN galactoside (CPN-G) synthesis was observed at 40 mM under the conditions that lactose and beta-gal (as E. coli cells) were 400 g/l and 4.8 U/ml, respectively, and the pH and temperature were 7.0 and 40oC, respectively. The time-course profile of CPN-G synthesis under these optimal conditions showed that CPN-G synthesis from 40 mM CPN reached a maximum of about 27 mM at 12 h. This value corresponded to an about 67% conversion of CPN to CPN-G, which was 4.47-5.36-fold higher than values in previous reports. In addition, we demonstrated by thin-layer chromatography to detect the sugar moiety that galactose was mainly transferred from lactose to CPN. Liquid chromatography-mass spectrometry revealed that CPN-G and CPN-GG (CPN galactoside, which accepted two galactose molecules) were definitively identified as the synthesized products using beta-gal-containing E. coli cells. In particular, because we did not use purified beta-gal, our beta-gal-containing E. coli cells might be practical and cost-effective for enzymatically synthesizing CPN-G. It is expected that the use of beta-gal-containing E. coli will be extended to galactose derivatization of other drugs to improve their functionality. (+info)Effect of chlorphenesin on localized hemolysis in gel assay. (3/5)
Chlorphenesin, a simple glycerol ether, when added to Jerne plates greatly reduced the number of hemolytic plaques. This effect appeared to be related to dose, and was clearly demonstrable with antibody-forming spleen cells from mice that had been immunized either with sheep red blood cells or with penicillin G conjugated with Keyhole limpet hemocyanin. Chlorphenesin did not affect the antigen, destroy complement, or interfere with the interaction of complement and the antigen-antibody complexes. Incubation of spleen cell suspensions with chlorphenesin prior to plating was more effective in reducing the number of plaques than was addition of the substance to the plates. It may act by reducing the ability of antibodies to react with antigens or by affecting the release of antibodies from the spleen cells. (+info)Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. (4/5)
The effects of chlorphenesin carbamate (CPC) and mephenesin on spinal neurons were investigated in spinal rats. CPC (50 mg/kg i.v.) inhibited the mono-(MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Mephenesin also inhibited MSR and PSR, though the effects were short in duration. CPC had no effect on the dorsal root potential evoked by the stimulation of the dorsal root, while mephenesin reduced the dorsal root-dorsal root reflex. The excitability of motoneuron was reduced by the administration of CPC or mephenesin. The excitability of primary afferent terminal was unchanged by CPC, while it was inhibited by mephenesin. Neither CPC nor mephenesin influenced the field potential evoked by the dorsal root stimulation. Both CPC and mephenesin had no effect on the synaptic recovery. These results suggest that both CPC and mephenesin inhibit the firing of motoneurons by stabilizing the neuronal membrane, while mephenesin additionally suppresses the dorsal root reflex and the excitability of the primary afferent terminal. These inhibitory actions of CPC on spinal activities may contribute, at least partly, to its muscle relaxing action. (+info)The action of chlorphenesin carbamate on the frog spinal cord. (5/5)
Studies were carried out to elucidate the mechanism of action of chlorphenesin carbamate (CPC) and to compare the effect of the drug with that of mephenesin on the isolated bullfrog spinal cord. Ventral and dorsal root potentials were recorded by means of the sucrose-gap method. CPC caused marked hyperpolarizations and depressed spontaneous activities in both of the primary afferent terminals (PAT) and motoneurons (MN). These hyperpolarizations were observed even in high-Mg2+ and Ca2+-free Ringer's solution, suggesting that CPC has direct actions on PAT and MN. Various reflex potentials (dorsal and ventral root potentials elicited by stimulating dorsal and ventral root, respectively) tended to be depressed by CPC as well as by mephenesin. Excitatory amino acids (L-aspartic acid and L-glutamic acid) caused marked depolarizations in PAT and MN, and increased the firing rate in MN. CPC did not modify the depolarization but abolished the motoneuron firing induced by these amino acids. However, mephenesin reduced both the depolarization and the motoneuron firing. The dorsal and ventral root potentials evoked by tetanic stimulation (40 Hz) of the dorsal root were depressed by the drugs. These results indicate that CPC has an apparent depressing action on the spinal neuron, and this action may be ascribed to the slight hyperpolarization and/or the prolongation of refractory period. (+info)
CHLORPHENESIN Archives - MedicScientist :: Total Health Portal
Chlorphenesin and estazolam Drug Interactions - Drugs.com
Chlorphenesin and J-TanD PD Drug Interactions - Drugs.com
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Mephenoxalone
Chlorphenesin Guaifenesin Mephenesin Metaxalone Methocarbamol Magnenat M (December 1961). "[The utilization in psychotherapy of ...
Mephenesin
Chlorphenesin Guaifenesin Mephenoxalone Methocarbamol Prenderol Bachmeyer C, Blum L, Fléchet M, Duriez P, Cabane J, Imbert J ( ...
Phenoxyethanol
... particularly when combined with chlorphenesin. Helmut Fiege; Heinz-Werner Voges; Toshikazu Hamamoto; Sumio Umemura; Tadao Iwata ...
List of drugs: Cf-Ch
... chlorphenesin (INN) chlorphenoctium amsonate (INN) chlorphenoxamine (INN) chlorphentermine (INN) chlorproethazine (INN) ...
Crookes Healthcare
... chlorphenesin) Karvol Dequacaine (Menthol flavoured Throat lozenges containing anaesthetic) In 2016 Nurofen was one of the ...
ATC code D01
... ethanol D01AE07 Chlorphenesin D01AE08 Ticlatone D01AE09 Sulbentine D01AE10 Ethyl hydroxybenzoate D01AE11 Haloprogin D01AE12 ...
Chlorphenesin carbamate
Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics ... Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. ... Kurachi M, Aihara H (September 1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". ... ATC code D01AE07 Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981. ...
Niaprazine
... (INN) (brand name Nopron) is a sedative-hypnotic drug of the phenylpiperazine group.[1][2] It has been used in the treatment of sleep disturbances since the early 1970s in several European countries including France, Italy, and Luxembourg.[3][4] It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential.[5][6][7][8][9][10] Originally believed to act as an antihistamine and anticholinergic,[11] niaprazine was later discovered to have low or no binding affinity for the H1 and mACh receptors (Ki = , 1 μM), and was instead found to act as a potent and selective 5-HT2A and α1-adrenergic receptor antagonist (Ki = 75 nM and 86 nM, respectively).[12] It possesses low or no affinity for the 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT (Ki = all , 1 μM), but it does have some affinity for the α2-adrenergic receptor (Ki = 730 nM),[12] likely acting as an antagonist there as well. Niaprazine ...
Pentamidine
... is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, Balamuthia infections,[2] babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function.[1] In African trypanosomiasis it is used for early disease before central nervous system involvement, as a second line option to suramin.[1] It is an option for both visceral leishmaniasis and cutaneous leishmaniasis.[1] Pentamidine can be given by injection into a vein or muscle or by inhalation.[1] Common side effects of the injectable form include low blood sugar, pain at the site of injection, nausea, vomiting, low blood pressure, and kidney problems.[1] Common side effects of the inhaled form include wheezing, cough, and nausea.[1] It is unclear if doses should be changed in those with kidney or liver problems.[1] Pentamidine is not recommended in early pregnancy but may be used in later pregnancy.[1] Its safety during breastfeeding is unclear.[3] Pentamidine is in the ...
Captodiame
... (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
Paraldehyde
... is the cyclic trimer of acetaldehyde molecules.[2] Formally, it is a derivative of 1,3,5-trioxane. The corresponding tetramer is metaldehyde. A colourless liquid, it is sparingly soluble in water and highly soluble in ethanol. Paraldehyde slowly oxidizes in air, turning brown and producing an odour of acetic acid. It quickly reacts with most plastics and rubber. Paraldehyde was first observed in 1835 by the German chemist Justus Liebig; its empirical formula was determined in 1838 by Liebig's student Hermann Fehling.[3][4] Paraldehyde was first synthesized in 1848 by the German chemist Valentin Hermann Weidenbusch (1821-1893), another student of Liebig; he obtained paraldehyde by treating acetaldehyde with acid (either sulfuric or nitric acid).[5][6] It has uses in industry and medicine. ...
1,1,1-Trichloroethane
... is generally considered a non-polar solvent. Owing to the good polarizability of the chlorine atoms, it is a superior solvent for organic compounds that do not dissolve well in hydrocarbons such as hexane. It is an excellent solvent for many organic materials and also one of the least toxic of the chlorinated hydrocarbons. Prior to the Montreal Protocol, it was widely used for cleaning metal parts and circuit boards, as a photoresist solvent in the electronics industry, as an aerosol propellant, as a cutting fluid additive, and as a solvent for inks, paints, adhesives, and other coatings. 1,1,1-Trichloroethane is also used as an insecticidal fumigant. It was also the standard cleaner for photographic film (movie/slide/negatives, etc.). Other commonly available solvents damage emulsion, and thus are not suitable for this application. The standard replacement, Forane 141 is much less effective, and tends to leave a residue. 1,1,1-Trichloroethane was used as a thinner in ...
Tiabendazole
The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestinal disorders at high exposure in test animals (just below LD50 level).[citation needed] Some reproductive disorders and decreasing weaning weight have been observed, also at high exposure. Effects on humans from use as a drug include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine occur.[citation needed] Carcinogenic effects have been shown at higher doses.[11] ...
Menthyl isovalerate
... , also known as validolum, is the menthyl ester of isovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble in ethanol, while practically insoluble in water. It is used as a food additive for flavor and fragrance.[1] ...
Metaxalone
... (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin is available in an 800 mg scored tablet. Possible side effects include nausea, vomiting, drowsiness and CNS side effects, such as dizziness, headache, and irritability. The metabolism of metaxalone involves the liver cytochrome P450 system. Based on the information in the labeling, patients receiving metaxalone therapy and physicians prescribing metaxalone are directed to take precaution when coadministering it with other medications involving the P450 system.[1][2] Because of potential for side effects, this drug is considered high risk in the elderly. As of 2015[update] the ...
Antifungal
A polyene is a molecule with multiple conjugated double bonds. A polyene antifungal is a macrocyclic polyene with a heavily hydroxylated region on the ring opposite the conjugated system. This makes polyene antifungals amphiphilic. The polyene antimycotics bind with sterols in the fungal cell membrane, principally ergosterol. This changes the transition temperature (Tg) of the cell membrane, thereby placing the membrane in a less fluid, more crystalline state. (In ordinary circumstances membrane sterols increase the packing of the phospholipid bilayer making the plasma membrane more dense.) As a result, the cell's contents including monovalent ions (K+, Na+, H+, and Cl−), small organic molecules leak and this is regarded one of the primary ways cell dies.[1] Animal cells contain cholesterol instead of ergosterol and so they are much less susceptible. However, at therapeutic doses, some amphotericin B may bind to animal membrane cholesterol, increasing the risk of human toxicity. Amphotericin B ...
Botulinum toxin
While botulinum toxin is generally considered safe in a clinical setting, there can be serious side effects from its use. The use of botulinum toxin A in cerebral palsy children is safe in the upper and lower limb muscles.[5][6] Most commonly, botulinum toxin can be injected into the wrong muscle group or with time spread from the injection site, causing temporary paralysis of unintended muscles. Side effects from cosmetic use generally result from unintended paralysis of facial muscles. These include partial facial paralysis, muscle weakness, and trouble swallowing. Side effects are not limited to direct paralysis however, and can also include headaches, flu-like symptoms, and allergic reactions.[41] Just as cosmetic treatments only last a number of months, paralysis side-effects can have the same durations.[citation needed] At least in some cases, these effects are reported to dissipate in the weeks after treatment.[citation needed] Bruising at the site of injection is not a side effect of the ...
Phenibut
... also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[9][16] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[9] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki , 1 mM).[9] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[9] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 ...
Cyclobarbital
... , also known as cyclobarbitol or cyclobarbitone, is a drug that is a barbiturate derivative.[1] It is primarily available in fixed-dose combination with diazepam under the brand name Reladorm (100 mg cyclobarbital + 10 mg diazepam) and is used to treat insomnia in Russia.[2] ...
Amobarbital
When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. Under the influence, a person will divulge information that under normal circumstances they would block. This was most likely due to loss of inhibition. As such, the drug was first employed clinically by Dr. William Bleckwenn at the University of Wisconsin to circumvent inhibitions in psychiatric patients.[7] The use of amobarbital as a truth serum has lost credibility due to the discovery that a subject can be coerced into having a "false memory" of the event.[8](subscription required)[citation needed] The drug may be used intravenously to interview patients with catatonic mutism, sometimes combined with caffeine to prevent sleep.[9] It was used by the United States armed forces during World War II in an attempt to treat shell shock and return soldiers to the front-line duties.[10] This use has since been discontinued as the powerful sedation, cognitive impairment, and ...
Zolpidem
... has potential for either medical misuse when the drug is continued long term without or against medical advice, or for recreational use when the drug is taken to achieve a "high".[53][54] The transition from medical use of zolpidem to high-dose addiction or drug dependence can occur with use, but some believe it may be more likely when used without a doctor's recommendation to continue using it, when physiological drug tolerance leads to higher doses than the usual 5 mg or 10 mg, when consumed through inhalation or injection, or when taken for purposes other than as a sleep aid.[53] Recreational use is more prevalent in those having been dependent on other drugs in the past, but tolerance and drug dependence can still sometimes occur in those without a history of drug dependence. Chronic users of high doses are more likely to develop physical dependence on the drug, which may cause severe withdrawal symptoms, including seizures, if abrupt withdrawal from zolpidem occurs.[55] Other ...
Clonazolam
... (also known as clonitrazolam) is a benzodiazepine that has had very little research done about its effects and metabolism, and has been sold online as a designer drug.[1][2][3][4][5] The synthesis of clonazolam was first reported in 1971 and the drug was described as the most active compound in the series tested.[6][7] Clonazolam is reported to be highly potent, and concerns have been raised that clonazolam and flubromazolam in particular may pose comparatively higher risks than other designer benzodiazepines, due to their ability to produce strong sedation and amnesia at oral doses of as little as 0.5 mg.[8] ...
U-90042
... is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. U-90042 is a GABAA agonist acting primarily at the α1, α3 and α6 subtypes, with a Ki of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6. It produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys, but does not produce amnesia and blocks the amnestic effect of diazepam, reflecting its different subtype affinity compared to benzodiazepine drugs.[1] It was developed by a team at Novo Nordisk in the 1980s.[2] ...
Dissociative
The effects of dissociatives can include sensory dissociation, hallucinations, mania, catalepsy, analgesia and amnesia.[5][6][7] The characteristic features of dissociative anesthesia were described as catalepsy, amnesia and analgesia.[5] According to Pender (1972), "the state has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment."[8] Bonta (2004) described dissociative anaesthesia as "... a peculiar anaesthetic state in which marked sensory loss and analgesia as well as amnesia is not accompanied by actual loss of consciousness."[9] Both Pender (1970) and Johnstone et al. (1959) reported that patients under anaesthesia due to either ketamine or phencyclidine were prone to purposeless movements and had hallucinations (or "dreams"[10]) during and after anaesthesia. Some patients found the hallucinations euphoric while others found them disturbing. At sub-anesthetic doses, dissociatives alter many of the same cognitive and perceptual ...
Neuromuscular-blocking drug
Neuromuscular blocking agents need to fit in a space close to 2 nanometres, which resembles the molecular length of decamethonium.[13] Some molecules of decamethonium congeners may bind only to one receptive site. Flexible molecules have a greater chance of fitting receptive sites. However, the most populated conformation may not be the best-fitted one. Very flexible molecules are, in fact, weak neuromuscular inhibitors with flat dose-response curves. On the other hand, stiff or rigid molecules tend to fit well or not at all. If the lowest-energy conformation fits, the compound has high potency because there is a great concentration of molecules close to the lowest-energy conformation. Molecules can be thin but yet rigid.[14] Decamethonium for example needs relatively high energy to change the N-N distance.[13] In general, molecular rigidity contributes to potency, while size affects whether a muscle relaxant shows a polarizing or a depolarizing effect.[3] Cations must be able to flow through ...
Methaqualone
... became increasingly popular as a recreational drug in the late 1960s and 1970s, known variously as "ludes" or "sopers" (also "soaps") in the United States and "mandrakes" and "mandies" in the UK, Australia and New Zealand. The drug was more tightly regulated in Britain under the Misuse of Drugs Act 1971 and in the U.S. from 1973. It was withdrawn from many developed markets in the early 1980s. In the United States it was withdrawn in 1982 and made a Schedule I drug in 1984. It has a DEA ACSCN of 2565 and in 2013 the aggregate annual manufacturing quota for the United States was 10 grams. Mention of its possible use in some types of cancer and AIDS treatments has periodically appeared in the literature since the late 1980s; research does not appear to have reached an advanced stage. The DEA has also added the methaqualone analogue mecloqualone (also a result of some incomplete clandestine syntheses) to Schedule I as ACSCN 2572, with zero manufacturing quota. Gene Haislip, the former ...
Desmethylflunitrazepam
Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080-1089. doi:10.1002/jms.3840. ISSN 1096-9888. PMID 27535017 ...
Clotrimazole
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
Depressant
A benzodiazepine (sometimes colloquially "benzo"; often abbreviated "BZD") is a drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring. The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann-La Roche, which has also marketed the benzodiazepine diazepam (Valium) since 1963. Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties; also seen in the applied pharmacology of high doses of many shorter-acting benzodiazepines are amnesic-dissociative actions. These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. Benzodiazepines are categorized as either short-, intermediate-, ...
Chlorphenesin carbamate - Wikipedia
Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics ... Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. ... Kurachi M, Aihara H (September 1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". ... ATC code D01AE07 Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981. ...
Chlorphenesin and pentobarbital Drug Interactions - Drugs.com
A Moderate Drug Interaction exists between chlorphenesin and pentobarbital. View detailed information regarding this drug ... You should avoid or limit the use of alcohol while being treated with chlorphenesin. Do not use more than the recommended dose ... Drug Interactions between chlorphenesin and pentobarbital. This report displays the potential drug interactions for the ... Alcohol can increase the nervous system side effects of chlorphenesin such as dizziness, drowsiness, and difficulty ...
Chlorphenesin and methyclothiazide Drug Interactions - Drugs.com
A Moderate Drug Interaction exists between chlorphenesin and methyclothiazide. View detailed information regarding this drug ... You should avoid or limit the use of alcohol while being treated with chlorphenesin. Do not use more than the recommended dose ... Drug Interactions between chlorphenesin and methyclothiazide. This report displays the potential drug interactions for the ... Methyclothiazide and chlorphenesin may have additive effects in lowering your blood pressure. You may experience headache, ...
Facial Cleanser Products Containing: CHLORPHENESIN || Skin Deep® Cosmetics Database | EWG
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
Antiprurit (Chlorphenesin; Hydrocortisone Acetate) Doetsch Grether
Tricho-Kolpicortin (Chlorphenesin; Enterococcus Faecalis; Escherichia Coli...) Dr. Kade
Effect of Chlorphenesin Carbamate (Maolate®) on a Case of Acute Arachnidism | The American Journal of Tropical Medicine and...
Chlorphenesin carbamate (Maolate®) was administered in doses of two 400-mg tablets about 1 hour after the bite and again 3 ... Effect of Chlorphenesin Carbamate (Maolate®) on a Case of Acute Arachnidism * Francis H. Stern ... Chlorphenesin carbamate (Maolate®) was administered in doses of two 400-mg tablets about 1 hour after the bite and again 3 ...
TRC | Details of CAS = 104-29-0, ChemicalName = 3-(4-Chlorophenoxy)-1,2-propanediol (Chlorphenesin), synonym = (±)-p...
p-Chlorphenesin; 3-(p-Chlorophenoxy)propane-1,2-diol; Adermykon; Chlorphenesin; Demykon; Elestab CPN; Gecophen; Glycerol α-p- ... Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. Chlorphenesin is also ... 3-(4-Chlorophenoxy)-1,2-propanediol (Chlorphenesin). Catalogue number:. C424250. Chemical name: 3-(4-Chlorophenoxy)-1 ... chlorophenyl ether; Mycil; NSC 6401; p-Chlorophenyl glyceryl ether; p-Chlorophenyl-α-glyceryl ether; p-Chlorphenesin;. ...
Chlorphenesin | CosDNA
Chlorphenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. ... Chlorphenesin is prepared by condensing equimolar amounts of p-chlorophenol and glycidol in the presence of a tertiary amine or ... Chlorphenesin is a preservative, widely used in cosmetics and compatible with most preservatives (including potassium sorbate, ... 1] Brown R (1981). Chlorphenesin sensitivity. Contact Dermatitis 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID ...
CHLORPHENESIN Archives - MedicScientist :: Total Health Portal
42 DERBY COOL have CHLORPHENESIN,ZINC is comes under Sub class #N/A of Main Class #N/A Main Medicine Class:: #N/A Sub Medicine ... 290 EXOMEGA EMOLLIENT have Niacinamide,PHENOXYETHANOL,CHLORPHENESIN,BENZOIC is comes under Sub class #N/A... DERBY COOL 150G 1, ... The Brand Name DERBY COOL Has Generic Salt :: CHLORPHENESIN,ZINC DERBY COOL Is From Company Ind-Swift Priced :: Rs. ... The Brand Name EXOMEGA EMOLLIENT Has Generic Salt :: Niacinamide,PHENOXYETHANOL,CHLORPHENESIN,BENZOIC EXOMEGA EMOLLIENT Is From ...
High Quality Chlorphenesin China Manufacturers & Suppliers & Factory
We are Professional Manufacturer of High Quality Chlorphenesin company, Factory & Exporters specialize in High Quality ... Find High Quality Chlorphenesin Manufacturers & Suppliers from China. ... Home > Tags > High Quality Chlorphenesin. (Total 24 Products for High Quality Chlorphenesin) ... High Quality Chlorphenesin - manufacturer, factory, supplier from China. * * high quality cas 2550-02-9 triethoxy(propyl)silane ...
Preservatives | Cosmetic Ingredient Dictionary | Paula's Choice
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Compare Current Muscle+Spasm Drugs and Medications with Ratings & Reviews
Compositions and methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid - Schneider, Louise M.
... chlorphenesin; ceteth-20; fragrance; witch hazel; and glycerin. In a further example, the present invention comprises a method ... chlorphenesin; benzyl alcohol and fragrance. In a further example, the present invention comprises a method of administering ... chlorphenesin; methylparaben; ceteth-20; and fragrance. In a further example, the present invention comprises a method of ... chlorphenesin; fragrance; polyacrylamide; C13-14 isoparaffin; and Laureth-7. In a further example, the present invention ...
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Category:Secondary alcohols - Wikimedia Commons
alcohol secundario (es); 第2級アルコール (ja); Alcool secondaire (fr); alkohol drugorzędowy (pl); вторичный спирт (ru); 仲醇 (lzh); 이차 알코올 (ko); secondary alcohol (en); sekundara alkoholo (eo); sekundární alkohol (cs); 仲醇 (zh) każdy alkohol, w którym grupa hydroksylowa przyłączona jest do drugorzędowego atomu węgla (pl) вторичные спирты (ru); Alcool Secondaire (fr); 2차 알코올 (ko); secondary alcohols (en); alkohole drugorzędowe (pl ...
Fixed Drug Eruptions: Background, Pathophysiology, Etiology
Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous pustulosis, ...
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Potassium Sorbate1
- Chlorphenesin is a preservative, widely used in cosmetics and compatible with most preservatives (including potassium sorbate, sodium benzoate and methyl isothiazolinone). (cosdna.com)
CAPRYLYL GLYCOL1
- Chlorphenesin, PEG-40 Hydrogenated Castor Oil, Caprylyl Glycol. (sephora.com)
Carbamate2
- Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. (wikipedia.org)
- Chlorphenesin carbamate (Maolate®) was administered in doses of two 400-mg tablets about 1 hour after the bite and again 3 hours later. (ajtmh.org)