Chlorotrianisene: A powerful synthetic, non-steroidal estrogen.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.Estradiol Congeners: Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Pamphlets: Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Patient Education as Topic: The teaching or training of patients concerning their own health needs.Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Medical Records Systems, Computerized: Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.Ethamoxytriphetol: A non-steroidal estrogen antagonist.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Estrogens, Non-Steroidal: Non-steroidal compounds with estrogenic activity.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Centchroman: A non-steroidal anti-fertility agent with anti-hormonal properties.Dyspareunia: Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.Selective Estrogen Receptor Modulators: A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)Raloxifene: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.Estrogen Receptor alpha: One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.Contraceptive Agents, Male: Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.Lubricants: Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION.Antipruritics: Agents, usually topical, that relieve itching (pruritus).Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Alberta: A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)British Columbia: A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Health Records, Personal: Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.Dermatitis, Exfoliative: The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)Erythema Multiforme: A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic "bull's-eye" lesions usually occurring on the dorsal aspect of the hands and forearms.Dermatitis Herpetiformis: Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.Adrenal Insufficiency: Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.Dermatitis, Seborrheic: A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.Food Additives: Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Cations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Pharmacological Processes: The metabolism of drugs and their mechanisms of action.

Large-scale prediction and testing of drug activity on side-effect targets. (1/3)

 (+info)

Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. (2/3)

Chlorotrianisene (TACE) exhibits in vitro little or no binding to the uterine estrogen receptor (ER) but demonstrates potent estrogenic activity in vivo, indicating that TACE is a proestrogen/proantiestrogen. Our earlier studies demonstrated that the incubation of TACE with rat liver microsomes and NADPH generates a reactive intermediate (T*) which binds covalently to proteins. The current study examined the possibility that T* may inactivate the uterine ER. The incubation of TACE with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate T*, markedly decreased the binding capacity of the ER for [3H]estradiol (E2). The evidence indicates that ER inactivation was probably due to irreversible (covalent) binding of T* to the E2 binding site. The possibility that the antiestrogenic action of TACE and of other triphenylethylenes involves such a novel mechanism is discussed.  (+info)

Effect of oestrogen on liver function of prostatic cancer patients. (3/3)

Liver function of patients with cancer of the prostate gland was studied while they were receiving oestrogen therapy. When synthetic oestrogens were given, raised values of serum aspartate and alanine amino-transferase (S.G.O.T. and S.G.P.T.) were found in about 30-50% of them. As treatment continued the increased values usually returned to normal levels. No serious liver damage was observed, though the serum bilirubin content rose temporarily in some patients.  (+info)

Estrobin, also known as α,α-di(p-ethoxyphenyl)-β-phenylbromoethylene and commonly abbreviated as DBE, is a synthetic, nonsteroidal estrogen of the triphenylethylene group that was never marketed.[1][2] Chlorotrianisene, and subsequently clomifene and tamoxifen, were derived from it.[1][2] Estrobin, similarly to other triphenylethylenes, is very lipophilic and hence very long-lasting in its duration of action.[1][2] Similarly to chlorotrianisene, estrobin behaves a prodrug to a much more potent estrogen in the body.[2] ...
This is a complete list of estrogens and formulations that are approved by the FDA and available in the United States. Estrogens are used as hormonal contraceptives, in hormone replacement therapy, and in the treatment of gynecological disorders. Conjugated estrogens (Premarin) - 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) - 0.3 mg, 0.625 mg, 1.25 mg, 2.5 mg Estradiol (Estradiol, Gynodiol, Innofem) - 0.5 mg, 1 mg, 2 mg Estradiol acetate (Femtrace) - 0.45 mg, 0.9 mg, 1.8 mg Estropipate (Estropipate, Ogen .625, Ogen 1.25, Ogen 2.5, Ogen 5, Ortho-Est) - 0.75 mg, 1.5 mg, 3 mg, 6 mg Synthetic conjugated estrogens (Cenestin, Enjuvia) - 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg Atypical (nitrogen mustard alkylating antineoplastic): Estramustine phosphate sodium (Emcyt) - 140 mg Discontinued: Chlorotrianisene (TACE) Dienestrol (Synestrol) Diethylstilbestrol (DES, Diethylstilbestrol, Stilbestrol, Stilbetin) Ethinylestradiol ...
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I prefer an alternate way of explaining things to the referring doctor , by keeping the patient in the loop. I document the entire discussion that I have with the patient, and send the complete consultation note to the general practitioner with the patient. This method has many benefits. The referring doctor understands my plan of action regarding the patients infertility. He has full information about the IVF procedure and what I am planning to do . More importantly, he can also check the patients understanding, so he can ensure she has realistic expectations of my treatment. This helps me to audit my consultation, and ensures that I have done a good job with clearing the patients doubts. At the same time the patient becomes the central part of the discussion. She is not left out from any information transfer. The referring doctor also gains confidence in the treatment offered at Malpani Infertility clinic. Since all the parties involved receive the same level of information , there is no ...
From pondering prehistoric man to employing high-tech 3-D imaging, Harvard researchers are leaving no shoe unturned to discover why we run, and how we can do it better.
A series of indanyl derivatives of diethylstilbestrol (DES) have recently been identified as inv vivo metabolites of DES. These compounds are of interest because they possess effective uterine estrogen receptor-binding affinity but poor biological activity. The X-ray crystal structures of three of these derivatives were determined and their conformations were compared with those of estradiol and DES. The more active derivatives, indenestrol A (I) and indenestrol B (II) have nearly identical conformations, in which the overall molecule is highly planar, the phenyl ring is twisted out of the plane of the indene rings by approximately 30 degrees, and the distance between the hydroxyl groups is 11.6 A. In the least active derivative, idanestrol (III), the methyl, ethyl, and phenyl substituents were found to be in the same side of the indane ring so that the molecule is constrained to an L-shape. The crystallographically observed conformations of I, II, III, DES, and estradiol, their competative ...
Chlorotrianisene. 12-24 mg/day Quadrosilan. 900 mg/day Estramustine phosphate. 140-1400 mg/day ...
Chlorotrianisene Triphenyliodoethylene Martin Negwer; Hans-Georg Scharnow (2001). Organic-chemical drugs and their synonyms: ( ...
Chlorotrianisene. Synthetic. Nonsteroidal. ?. ,100 mg. ?. ?. ,48 mg. ? Methallenestril. Synthetic. Nonsteroidal. ?. 400 mg. ?. ...
Scientists at Merrell had previously synthesized chlorotrianisene and ethamoxytriphetol. One of Richardson-Merrell's best-known ...
Allenolic acid Diethylstilbestrol Stilbestrol Chlorotrianisene Triphenylethylene R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. ...
Similarly to chlorotrianisene, estrobin behaves a prodrug to a much more potent estrogen in the body. Broparestrol ... Chlorotrianisene, and subsequently clomifene and tamoxifen, were derived from it. Estrobin, similarly to other ... 23-. ISBN 978-0-299-10480-1. Welsh, Ashton L. (1954). "USE OF SYNTHETIC ESTROGENIC SUBSTANCE CHLOROTRIANISENE (TACE) IN ...
It includes the estrogens chlorotrianisene, estrobin (DBE), triphenylbromoethylene, triphenylchloroethylene, ...
Chlorotrianisene, methallenestril, and doisynoestrol are nonsteroidal estrogens structurally distinct from the stilbestrols ...
... a similar structure to stilbestrol derivatives like diethylstilbestrol and triphenylethylene derivatives like chlorotrianisene ...
... an enzyme Chlorotrianisene, a synthetic estrogen Tamil All Character Encoding - TACE-16. ...
... is a triphenylethanol and was derived from chlorotrianisene (TACE), a nonsteroidal triphenylethylene estrogen, and ...
... chlorotrianisene, broparestrol, ethamoxytriphetol, clomifene, tamoxifen, and more recently developed derivatives is also very ...
Broparestrol Chlorotrianisene Estrobin Proceedings of the XIth International Congress of Pure and Applied Chemistry: Chemistry ...
Chlorotrianisene (TACE) Dienestrol (Synestrol) Diethylstilbestrol (DES, Diethylstilbestrol, Stilbestrol, Stilbetin) ...
... which itself was derived from the estrogen chlorotrianisene (also known as TACE)), was originally being studied in animals at ...
... chlorotrianisene, estrobin (DBE), triphenylbromoethylene, triphenylchloroethylene, triphenyliodoethylene, ...
Chlorotrianisene, or tri-p-anisylchloroethylene (TACE), is a potent marketed estrogen and a derivative of ...
... chlorotrianisene MeSH D02.455.426.559.389.150.700.125 --- clomiphene MeSH D02.455.426.559.389.150.700.175 --- ...
... chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, ...
... chlorotrianisene (INN) chloroxylenol (INN) Chlorphed chlorphenamine (INN) chlorphenesin (INN) chlorphenoctium amsonate (INN) ...
G03CA01 Ethinylestradiol G03CA03 Estradiol G03CA04 Estriol G03CA06 Chlorotrianisene G03CA07 Estrone G03CA09 Promestriene ...
An example of a SERM with high IA and thus mostly estrogenic effects is chlorotrianisene, while an example of a SERM with low ...
As an example, chlorotrianisene produces gynecomastia in men, albeit reportedly to a lesser extent than other estrogens, while ... Chlorotrianisene (INN, USAN, BAN; brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others; also known ...
Notes: Values are mean ± SD or range. ER RBA = Relative binding affinity to estrogen receptors of rat uterine cytosol. Uterine weight = Percentage change in uterine wet weight of ovariectomized rats after 72 hours with continuous administration of 1 μg/hour via subcutaneously implanted osmotic pumps. LH levels = Luteinizing hormone levels relative to baseline of ovariectomized rats after 24 to 72 hours of continuous administration via subcutaneous implant. Footnotes: a = Synthetic (i.e., not endogenous). b = Atypical uterotrophic effect which plateaus within 48 hours (estradiol's uterotrophy continues linearly up to 72 hours). Sources: See template ...
Chlorotrianisene. *Dienestrol *Dienestrol diacetate. *Diethylstilbestrol (stilbestrol). *Diethylstilbestrol esters/ethers * ...
Other names: Ethylene, chlorotris(p-methoxyphenyl)-; Anisene; Chlorotrianisine; Chlorotris(p-methoxyphenyl)ethylene; Chlortrianizen; Clorestrolo; Clorotrisin; Hormonisene; Khlortrianizen; Merbentul; Metace; NSC-10108; Rianil; Tace; Tri-p-anisylchloroethylene; Tris(p-methoxyphenyl)chloroethylene; Chloortrianisestrol; Chlortrianisestrol; Chlorestrolo; 1,1,1-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene); Chlorotrianizen; Chlorotrisin; Chlortrianisen; CTA; Tace-fn; Trianisestrol; Benzene, 1,1,1-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-; Tace (pharmaceutical ...
As an example, chlorotrianisene produces gynecomastia in men, albeit reportedly to a lesser extent than other estrogens, while ... Chlorotrianisene (INN, USAN, BAN; brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others; also known ...
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chlorotrianisene ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
List of frequently occuring side effects for chlorotrianisene. Sources include the official FAERS database and social media ... Chlorotrianisene Side Effects. Filter Table by Serious Outcome. ×. Filter by Serious Outcome. ... View full report on Chlorotrianisene related hepatic failure Did the author experience hepatic failure while taking tace? ... View full report on Chlorotrianisene related decreased appetite Did the author experience decreased appetite while taking tace ...
Chlorotrianisene [USP:INN:BAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. ... Substance Name: Chlorotrianisene [USP:INN:BAN]. RN: 569-57-3. UNII: 6V5034L121. InChIKey: BFPSDSIWYFKGBC-UHFFFAOYSA-N. Note. * ...
Chlorotrianisene. A. Evidence for carcinogenicity to animals (inadequate) Chlorotrianisene was tested in only one experiment in ... Chlorotrianisene. CAS No.: 569-57-3. Chem. Abstr. Name:1,1,l"-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene). ... Synonyms for Chlorotrianisene. * Anisene * Chlorestrolo *Chlorotrianisine * Chlorotrianizen * Chlorotrisin * Chlorotris-(para- ...
Diethylstilbestrol (DES) is an estrogen that was first manufactured in a laboratory in 1938, so it is called a "synthetic estrogen." During 1938-1971, U.S. physicians prescribed DES to pregnant women to prevent miscarriages and avoid other pregnancy problems. As a result, an estimated 5-10 million pregnant women and the children born of these pregnancies were exposed to DES. Physicians prescribed DES to pregnant women on the theory that miscarriages and premature births occurred because some pregnant women did not produce enough estrogen naturally. At the time, physicians thought DES was safe and would prevent miscarriages and pre-term (early) births.. In 1953, published research showed that DES did not prevent miscarriages or premature births. However, DES continued to be prescribed until 1971. In that year, the Food and Drug Administration (FDA) issued a Drug Bulletin advising physicians to stop prescribing DES to pregnant women. The FDA warning was based on a study published in 1971 that ...
Chlorotrianisene. 12-24 mg/day Quadrosilan. 900 mg/day Estramustine phosphate. 140-1400 mg/day ...
The following content is no longer maintained and may be out of date. Persons with disabilities having difficulty accessing the information on this page may contact [email protected] for assistance. Please view the Updated Bibliographies on the Updated Bibliographies page for updated information on this topic. ...
Chlorotrianisene. Adefovir. Adefovir dipivoxil. Estrogens, Non-Steroidal. Estrogens. Hormones. Hormones, Hormone Substitutes, ...
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset ...
Detailed drug Information for Aplenzin. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Chlorotrianisene. Niacinamide. Antineoplastic Agents. Protein Kinase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Do not take naltrexone and bupropion combination with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking naltrexone and bupropion combination during the 2 weeks after you stop a MAO inhibitor. Wait 2 weeks after stopping naltrexone and bupropion combination before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Do not use naltrexone and bupropion combination if you are also using Zyban® to quit smoking or Aplenzin® or Wellbutrin® for depression, because they also contain bupropion. Also, do not take this medicine if you are using or have used narcotic drugs (such as buprenorphine, methadone, or other habit-forming painkillers) within the past 7 to 10 days. This medicine may cause ...
d) Chlorotrianisene inhibits platelet aggregation. Two independent experiments (red and blue) shown for chlorotrianisene and ... Chlorotrianisene is only marginally similar to indomethacin, but is (correctly) predicted for COX-1. (d) Sequence similarities ... Hit rates of SEA (red) and 1NN (blue) with s.d. (c) Non-intuitive (chlorotrianisene) and straightforward (medrysone) SEA ... Among these new associations was the prediction that the abdominal pain side effect of the synthetic oestrogen chlorotrianisene ...
Chlorotrianisene. Synthetic. Nonsteroidal. ?. ,100 mg. ?. ?. ,48 mg. ? Methallenestril. Synthetic. Nonsteroidal. ?. 400 mg. ?. ...
Chlorotrianisene Triphenyliodoethylene Martin Negwer; Hans-Georg Scharnow (2001). Organic-chemical drugs and their synonyms: ( ...
Welsh, Ashton L. (1954). "USE OF SYNTHETIC ESTROGENIC SUBSTANCE CHLOROTRIANISENE (TACE) IN TREATMENT OF ACNE". Archives of ... Chlorotrianisene, and subsequently clomifene and tamoxifen, were derived from it.[1][2] Estrobin, similarly to other ... Similarly to chlorotrianisene, estrobin behaves a prodrug to a much more potent estrogen in the body.[2] ...
Chlorotrianisene. The risk or severity of adverse effects can be increased when Chlorotrianisene is combined with Ospemifene.. ...
Chlorotrianisene. The serum concentration of Alclometasone can be increased when it is combined with Chlorotrianisene.. ...
Chlorotrianisene may also be used to prevent breast engorgement following childbirth.. DB00481. Raloxifene. For the prevention ... Chlorotrianisene. Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female ...
Chlorotrianisene may also be used to prevent breast engorgement following childbirth.. DB00351. Megestrol acetate. For the ... Chlorotrianisene. Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female ...
  • For example, the estrogen receptor (ESR1) modulator chlorotrianisene was found to inhibit PTGS1 (COX-1), indeed with an affinity substantially better than its affinity for ESR1. (nih.gov)
  • Drugs that modulate the two proteins can share two of chlorotrianisene's adverse reactions, "erythema multiforme" and "oedema", but "rash" and "abdominal pain upper" link only to drugs inhibiting COX-1, and both of these are associated with chlorotrianisene almost uniquely among the estrogen receptor modulators (Figure 2a, Supplementary TableS5). (nih.gov)
  • Chlorotrianisene is a synthetic, non-steroidal estrogen. (selleckchem.com)
  • Among these new associations was the prediction that the abdominal pain side effect of the synthetic oestrogen chlorotrianisene was mediated through its newly discovered inhibition of the enzyme cyclooxygenase-1. (nih.gov)
  • Among these new associations was the prediction that the abdominal pain side effect of the synthetic oestrogen chlorotrianisene was mediated through its newly discovered inhibition of the enzyme cyclooxygenase-1.The clinical relevance of this inhibition was borne out in whole human blood platelet aggregation assays.This approach may have wide application to de-risking toxicological liabilities in drug discovery. (nih.gov)
  • Lynestrenol, also known as 17α-ethynyl-3-desoxy-19-nortestosterone or as 17α-ethynylestr-4-en-17β-ol, is a synthetic estrane steroid and a derivative of 19-nortestosterone . (wikipedia.org)
  • Chlorotrianisene may also be used to prevent breast engorgement following childbirth. (drugbank.ca)
  • Additionally, clomiphene in an array of isomeric ratios (EN:ZU) can be used alone for prevention of osteoporosis, maintenance of a healthful blood lipid profile, and prevention of breast tumors, or to sustain amenorrhea. (justia.com)
  • Chlorotrianisene is only marginally similar to indomethacin, but is (correctly) predicted for COX-1. (nih.gov)