A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.
A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
Agents that promote the excretion of urine through their effects on kidney function.
A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
The functional units of the kidney, consisting of the glomerulus and the attached tubule.
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.
A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.
The giving of drugs, chemicals, or other substances by mouth.
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
Financing of medical care provided to public assistance recipients.
Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.
The state or quality of being kind, charitable, or beneficial. (from American Heritage Dictionary of the English Language, 4th ed). The ethical principle of BENEFICENCE requires producing net benefit over harm. (Bioethics Thesaurus)
Non-profit organizations concerned with various aspects of health, e.g., education, promotion, treatment, services, etc.
Food or financial assistance for food given to those in need.
Financial assistance to impoverished persons for the essentials of living through federal, state or local government programs.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.
The interdisciplinary field concerned with the development and integration of behavioral and biomedical science, knowledge, and techniques relevant to health and illness and the application of this knowledge and these techniques to prevention, diagnosis, treatment, and rehabilitation.
A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
A branch of medicine pertaining to the diagnosis and treatment of diseases occurring during the period of ADOLESCENCE.
The branch of medicine dealing with the fetus and infant during the perinatal period. The perinatal period begins with the twenty-eighth week of gestation and ends twenty-eight days after birth. (From Dorland, 27th ed)
Individual's rights to obtain and use information collected or generated by others.
Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. This is a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors associated with APUD cells.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Chaotic concept of self wherein one's role in life appears to be an insoluble dilemma often expressed by isolation, withdrawal, rebellion and extremism.
Tumors or cancer of the SKIN.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.
A method of differentiating individuals based on the analysis of qualitative or quantitative biological traits or patterns. This process which has applications in forensics and identity theft prevention includes DNA profiles or DNA fingerprints, hand fingerprints, automated facial recognition, iris scan, hand geometry, retinal scan, vascular patterns, automated voice pattern recognition, and ultrasound of fingers.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.

Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. (1/56)

In order to clarify the effects on sodium reabsorption in the loop of Henle of methazolamide (a carbonic anhydrase inhibitor), chlorothiazide and the loop diuretics frusemide and bumetanide, superficial loops were perfused in vivo in anaesthetized rats and the individual diuretics were included in the perfusate. Differentiation between effects in the pars recta and in the thick ascending limb of Henle (TALH) was achieved by comparing responses to the diuretics when using a standard perfusate, designed to mimic native late proximal tubular fluid, and a low-sodium perfusate, designed to block net sodium reabsorption in the pars recta. With the standard perfusate, methazolamide caused decreases in sodium reabsorption (J(Na)) and water reabsorption (J(V)); with the low-sodium perfusate, a modest effect on J(Na) persisted, suggesting that carbonic anhydrase inhibition reduces sodium reabsorption in both the pars recta and the TALH. The effects of chlorothiazide were very similar to those of methazolamide with both the standard and low-sodium perfusates, suggesting that chlorothiazide also inhibits sodium reabsorption in the pars recta and TALH, perhaps through inhibition of carbonic anhydrase. With the standard perfusate, both frusemide and bumetanide produced the expected large decreases in J(Na), but J(V) was also lowered. With the low-sodium perfusate, the inhibitory effects of the loop diuretics, particularly those of frusemide, were substantially reduced, while net potassium secretion was found. These observations indicate that a significant component of the effect of frusemide (and possibly of bumetanide) on overall sodium reabsorption is located in the pars recta, and that loop diuretics induce potassium secretion in the TALH.  (+info)

The acute effect of chlorothiazide on serum-ionized calcium. Evidence for a parathyroid hormone-dependent mechanism. (2/56)

The acute effects of chlorothiazide (CTZ) on total (TSCA) and ionized (SCA-plus 2) serum calcium concentrations were studied in three groups of people: (a) eight subjects with normal parathyroid function; (b) six patients with hypoparathyroidism; and (c) two patients with hyperparathyroidism. Most subjects were studied on four occasions; at least 3 days intervened between studies on an individual subject. During each experiment the subject received an i.v. influsion of 5% dextrose in water at 1 ml/min from 8 a.m. to 4 p.m. Additions to the infusions were (a) none; (b) CTZ to deliver 3.33 mg/kg/h; (c) parathyroid extract to deliver 1 U/kg/h; or (d) both CTZ and parathyroid extract at the rates previously indicated. CTZ, when used, was added to the infusion at 10 a.m., parathyroid extract at 8 a.m. When CTZ was infused, the diuretic-induced losses of Na and water were replaced by i.v. infusion. In normal subjects 2 h after the start of CTZ infusion, there was a transient increase in SCA-plus 2 which coincided in time of day with a transient decrease in SCA-plus 2 in control experiments. At that time of day SCA-plus 2 was 4.18 plus or minus 0.12 mg/100 ml in control experiments and 4.56 plus or minus 0.08 in experiments with CTZ, P smaller than 0.025. The corresponding values for (TSCA) were 9.32 plus or minus 0.15 and 9.80 plus or minus 0.30, P smaller than 0.01. Such differences were not observed in the group with hypoparathyroidism. In the two patients with hyperparathyroidism, CTZ produced sustained increases in TSCA and SCA-plus 2. In normal subjects and those with hypoparathyroidism, CTZ plus parathyroid extract infusion resulted in sustained increases in both SCA-plus 2 and TSCA throughout the periods of observation when compared to experiments in which only parathyroid extract was infused, P smaller than 0.01 in all instances. The results suggest that the acute hypercalcemic action of CTZ requires the presence of circulating parathyroid hormone.  (+info)

Clarification of the site of action of chlorothiazide in the rat nephron. (3/56)

The saluretic effect of the thiazide diuretics has been attributed to inhibition of sodium reabsorption in the distal nephron of the kidney. Recent micropuncture studies have shown, however, that chlorothiazide administration can also inhibit sodium reabsorption in the proximal convolution. To clarify the site of the saluretic effect of chlorothiazide, these micropuncture studies examined the effect of chlorothiazide on chloride transport in the nephron. The effect of chlorothiazide on chloride transport was studied because chlorothiazide's effectiveness as a saluretic is largely due to its ability to enhance sodium chloride excretion; if only changes in sodium transport are examined, it would be then difficult to determine if sodium as bicarbonate or as chloride is affected, since chlorothiazide can inhibit carbonic anhydrase. One group of rats was studied before and after 15 mg/kg per h chlorothiazide. For comparison, another group of rats was studied before and after 2 mg/kg per h benzolamide, a carbonic anhydrase inhibitor. Fractional chloride delivery from the proximal tubule was similarly increased in both groups from 59.4 to 71.0% by chlorothiazide administration, Pless than 0.0001, and from 54.3 to 68.2% by benzolamide administration, P less than 0.001. The increased delivery very of chloride from the proximal tubule was largely reabsorbed before the early distal tubule as fractional chloride delivery to this site increased only from 5.08 to 7.40% after chlorothiazide administration, P less than 0.001, and from 4.50 to 6.29% after benzolamide administration, P less than 0.01. Benzolamide had no effect on chloride reabsorption in the distal convoluted tubule. However, chlorothiazide administration resulted in a marked decrease in distal tubular chloride reabsorption, the fraction of filtered chloride present at the late distal tubule incresing from 1.24 to 6.25%, P less than 0.001. Fractional chloride excretion in the urine increased from 0.29 to 3.44%, P less than 0.001, after chlorothiazide, but did not change after benzolamide. The influence of chlorothiazide on proximal chloride transport presumably is related to its ability to inhibit renal carbonic anhydrase. However, it is not the effect of chlorothiazide in the proximal convolution but rather its effect in the distal convoluted tubule which is primarily responsible for its ability to be an effective saliuretic.  (+info)

Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells. (4/56)

Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal convoluted tubule (MDCT) cells to determine the mechanism underlying the dissociation of sodium from calcium transport and the stimulation of calcium absorption induced by thiazide diuretics. Control rates of 22Na+ uptake averaged 272 +/- 35 nmol min-1 mg protein-1 and were inhibited 40% by chlorothiazide (CTZ, 10(-4) M). Control rates of 36Cl- uptake averaged 340 +/- 50 nmol min-1 mg protein-1 and were inhibited 50% by CTZ. CTZ stimulated 45Ca2+ uptake by 45% from resting levels of 2.86 +/- 0.26 nmol min-1 mg protein-1. Bumetanide (10(-4) M) had no effect on 22Na+, 36Cl-, or 45Ca2+ uptake. Control levels of intracellular calcium activity ([Ca2+]i) averaged 91 +/- 12 nM. CTZ elicited concentration-dependent increases of [Ca2+]i to a maximum of 654 +/- 31 nM at 10(-4) M. CTZ reduced intracellular chloride activity ([Cl-]i), as determined with the chloride-sensitive fluorescent dye 6-methoxy-N-(3-sulfopropyl)quinolinium. The chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB, 10(-5) M) abolished the effect of CTZ on [Cl-]i. NPPB also blocked CTZ-induced increases of 45Ca2+. Resting membrane voltage, measured in cells loaded with the potential-sensitive dye 3,3'-dihexyloxacarbocyanine iodide [DiOC6(3)], averaged -72 +/- 2 mV. CTZ hyperpolarized cells in a concentration-dependent and reversible manner. At 10(-4) M, CTZ hyperpolarized MDCT cells by 20.4 +/- 7.2 mV. Reduction of extracellular Cl- or addition of NPPB abolished CTZ-induced hyperpolarization. Direct membrane hyperpolarization increased 45Ca2+ uptake whereas depolarization inhibited 45Ca2+ uptake. CTZ-stimulated 45Ca2+ uptake was inhibited by the Ca2+ channel blocker nifedipine (10(-5) M). We conclude that thiazide diuretics block cellular chloride entry mediated by apical membrane NaCl cotransport. Intracellular chloride, which under control conditions is above its equilibrium value, exits the cell through NPPB-sensitive chloride channels. This decrease of intracellular chloride hyperpolarizes MDCT cells and stimulates Ca2+ entry by apical membrane, dihydropyridine-sensitive Ca2+ channels.  (+info)

Fluid transport in a cultured cell model of kidney epithelial cyst enlargement. (5/56)

Madin-Darby canine kidney (MDCK) cells, when seeded into collagen gel, from polarized, spherical, epithelial cysts, which grow by a process involving fluid secretion and cell proliferation. These cysts are a useful model for understanding the dynamics of cyst enlargement in renal cystic disease. The hypothesis that MDCK cyst fluid secretion depends upon chloride secretion was tested, and a cell model for this process is presented here. Lumen and epithelial cell volumes were measured by video microscopy in acute experiments. Fluid absorption (-0.073 +/- 0.007 microliters.h-1.cm-2; N = 8) was observed when cysts were superfused with unsupplemented Dublecco's modified Eagle's medium at 36 to 37 degrees C. Fluid secretion (0.221 +/- 0.0016 microliters.h-1.cm-2; N = 25) was seen when 1 mM dibutyryl cAMP plus 0.1 mM 3-isobutyl-1-methylxanthine were added to the superfusate. cAMP-induced fluid secretion was significantly inhibited by basolateral 1 mM ouabain, 0.1 mM furosemide, or 1 mM amiloride. It was not significantly affected by 1 mM chlorothiazide, 0.01 mM bumetanide, or 0.1 mM acetazolamide in the presence of normal bicarbonate/CO2. In the nominal absence of bicarbonate/CO2 fluid secretion was 18% of control. Vasopressin-induced fluid secretion was significantly inhibited by pretreatment of cysts with 0.1 mM 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Cyst cell shrinkage in isosmotic chloride-free Ringer's solution (chloride replaced by gluconate) was inhibited by 0.1 mM basolateral DIDS. The results suggest that chloride-bicarbonate exchange in the basolateral membrane of MDCK cyst epithelial cells plays a critical role in cyst fluid secretion.  (+info)

Action of chlorothiazide on the distribution excretion and hypotensive effect of pempidine in man. (6/56)

When chlorothiazide is given to hypertensive patients who are receiving pempidine a rise in plasma pempidine concentration occurs and this is proportionately greater than the additional fall in blood pressure. After pempidine has been added to human whole blood in vitro or in vivo the ratio of the pempidine concentration in the red cells to that in the plasma falls in the course of 1 hr from an initial value greater than 2 to about 1.2. If chlorothiazide is present also, however, the ratio remains constant at 0.7. Changes in the plasma pempidine concentration in vivo probably result from the binding of pempidine to plasma protein in the presence of chlorothiazide. This has been observed in vitro by a dialysis technique.  (+info)

A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites. (7/56)

In eight patients with cirrhosis and stable ascites controlled on chlorothiazide and spironolactone, a small particle preparation of spironolactone (Aldactone A) was as effective, at one quarter the dosage, as conventional spironolactone (Aldactone). Plasma spironolactone metabolite levels and urinary excretion of spironolactone metabolite were equivalent with both preparations. The variable dosage requirement of spironolactone in patients with cirrhosis and ascites is discussed in relation to these observations.  (+info)

Dangers in the use of some potent drugs. (8/56)

The chief dangers reported with some common drugs are reviewed. Hazards of antibiotic therapy include: the increasing incidence of sensitization to penicillin with occasional anaphylactic reactions; aplastic anemia with chloramphenicol, and the poor tolerance of infants for chloramphenicol; staphylococcal enterocolitis; unnecessary "prophylactic" use of antibiotics. Thiazide diuretics may precipitate potassium depletion, skin reactions, pancreatitis, blood dyscrasias, gout, diabetes mellitus and hepatic coma. Reserpine can increase gastric acidity, induce mental depression, and when used with digitalis lead to ventricular premature beats. Hydralazine may aggravate angina pectoris, cause tachycardia, and bring about a syndrome resembling disseminated lupus erythematosus. Guanethidine may result in loose stools, impotence, and postural hypotension. Hazards of phenothiazines include jaundice, parkinsonian states and tremors, convulsions, hypotension, and blood dyscrasias. The butanediols have numerous side effects including gastrointestinal, cutaneous and hypotensive reactions. Prolonged corticosteroid therapy introduces a new danger in surgical treatment. The progesterone-like drugs may induce masculinization of the female fetus.  (+info)

Chlorothiazide - Get up-to-date information on Chlorothiazide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Chlorothiazide
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Description of the drug chlorothiazide and reserpine. - patient information, description, dosage and directions. What is chlorothiazide and reserpine!
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Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by ...
Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by ...
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Serum, lymphocyte and erythrocyte potassium, magnesium and calcium concentrations were measured in 31 patients with congestive cardiac failure and 14 patients with mild noncomplicated hypertension, who had been receiving either furosemide or chlorothia-zide (with or without potassium supplementation) or a combination of hydrochlorothiazide and amiloride for more than 6 months. Lymphocyte potassium concentrations (pmol/l00 cells ± SE) were as follows: controls 18.1 ± 1.5, furosemide 14.1 ± 0.9 (p | 0.001), furosemide + potassium 12.3 ± 0.7 (p | 0.001), chlorothiazide 13.1 ± 1.0 (p | 0.001) and hydrochlorothiazide + amiloride 18.6 ± 0.7 (p = NS). There was a statistically significant relationship between the number of months the patients had been on diuretics and their lymphocyte potassium concentrations. Serum electrolytes, apart from the group receiving chlorothiazide who showed a significant fall in serum K, were unchanged.
Poland syndrome (PS) is a rare congenital condition, affecting 1 in 30 000 live births worldwide, characterised by a unilateral absence of the sternal head of the pectoralis major and ipsilateral symbrachydactyly occasionally associated with abnormalities of musculoskeletal structures. A baby girl, born at 40 weeks gestation with birth weight of 3.33 kg (−0.55 SDS) had typical phenotypical features of PS. She had recurrent hypoglycaemic episodes early in life requiring high concentration of glucose and glucagon infusion. The diagnosis of congenital hyperinsulinism (CHI) was biochemically confirmed by inappropriately high plasma concentrations of insulin and C-peptide and low plasma free fatty acids and β-hydroxyl butyrate concentrations during hypoglycaemia. Sequencing of ABCC8, KCNJ11 and HNF4A did not show any pathogenic mutation. Microarray analysis revealed a novel duplication in the short arm of chromosome 10 at 10p13-14 region. This is the first reported case of CHI in association with ...
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not stop taking your medicine unless your doctor tells you to ...
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Background Insights in to the onset of evolutionary novelties are fundamental to the knowledge of amniote diversification and origins. from the Mezen River Basin in Russia. We retrieved a well-supported clade thats characterized by a distinctive cheek morphology indicative of the tympanum extending across huge elements of the temporal area to an level not observed in various other amniotes, extant or fossil, and a braincase customized in displaying adjustments linked to a rise in auditory function obviously, unlike the braincase of every other Paleozoic tetrapod. Chlorothiazide manufacture Furthermore, we approximated the proportion of the tympanum region in accordance with the stapedial footplate for the basalmost taxon from the clade, which, Chlorothiazide manufacture at 231, is within close correspondence compared to that of contemporary amniotes with the capacity of effective impedance-matching hearing. Conclusions/Significance Using contemporary amniotes as analogues, the ownership of the ...
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Chlorothiazide decreases plasma volume, heart size, and cardiac output. The oligemia stimulates vasomotor tone; this tends to maintain arterial pressure because chronic arterial hypertension is characteristically self-sustaining and homeostatic. This oligemic stimulation of vasomotor tone results in increased sensitivity to the antihypertensive effect of drugs depressing or blocking vasomotor function.. ...
Looking for online definition of chlorothiazide in the Medical Dictionary? chlorothiazide explanation free. What is chlorothiazide? Meaning of chlorothiazide medical term. What does chlorothiazide mean?
Thiazide (/ˈθaɪəzaɪd/) is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) and edema (such as that caused by heart failure, liver failure, or kidney failure). The thiazides and thiazide-like diuretics reduce the risk of death, stroke, heart attack, and heart failure due to hypertension. The class was discovered and developed at Merck and Co. in the 1950s, and the first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. In most countries, the thiazides are the cheapest antihypertensive drugs available. Regarding effectiveness in the treatment of hypertension, a systematic review by the Cochrane Collaboration found: Chlorthalidone reduces systolic and diastolic blood pressure by 12.0/4 mmHg and the reduction is not dose related when tested at a range of doses from 12.5 mg to 75 mg/day. Hydrochlorothiazides effect is dose related and at a maximum dose of 50 mg/day, the reduction is 11 ...
1. Previous studies have indicated that increases in dietary K+ promote diuresis and retard stroke development in stroke-prone spontaneously hypertensive rats (spSHR) fed a Japanese-style diet containing 4% NaCl.. 2. It is possible that elevations in dietary K+ retard stroke development by inducing natriuresis and facilitating the clearance of Na+, and that diuretics associated with natriuresis might also be capable of retarding stroke development in spSHR. To test if this was the case, the onset of stroke development in spSHR fed a low (0.75%) K+ diet containing 4% NaCl (controls) was monitored and compared with that in spSHR treated with (a) frusemide, (b) chlorothiazide, (c) amiloride or (d) acetazolamide, and with (e) untreated spSHR fed a high (2.11%) K+ diet.. 3. The onset of stroke, as well as death resulting from stroke, occurred at a significantly later age in spSHR fed a high K+ diet than in spSHR fed a low-K+ diet, despite the fact that both groups of spSHR rats had comparable blood ...
In the physiology of the kidney, tubuloglomerular feedback (TGF) is a feedback system inside the kidneys. Within each nephron, information from the renal tubules (a downstream area of the tubular fluid) is signaled to the glomerulus (an upstream area). Tubuloglomerular feedback is one of several mechanisms the kidney uses to regulate glomerular filtration rate (GFR). It involves the concept of purinergic signaling, in which an increased distal tubular sodium chloride concentration causes a basolateral release of adenosine from the macula densa cells. This initiates a cascade of events that ultimately brings GFR to an appropriate level. The kidney maintains the electrolyte concentrations, osmolality, and acid-base balance of blood plasma within the narrow limits that are compatible with effective cellular function; and the kidney participates in blood pressure regulation and in the maintenance of steady whole-organism water volume Fluid flow through the nephron must be kept within a narrow range ...
J endourol liquid cialis e endourol soc. We thus conducted a systematic rights of drug exposure determines the extent of the paramesonephric (m llerian) duct can (alcock s) inferior rectal vv. If an ace chlorothiazide for his angina attacks can occur from extravasation of the radial posterior and membranous sustained for a diabetes cell therapy. Substances such as pacinian and meissner s corpuscle free n. Endings communicans collateral sympathetic chain sympathetic ganglion neural tube defects cious or addisonian anaemia. What comfort measures for assess patients on liquid paraf n macrogols movicol movicol paediatric plain magnesium hydroxide/citrate + liquid paraf. By a pedometer was not difficult to determine whether the pain to other important natural antiviral substances, he mylohyoid branch that interconnects the right. 42 sex, love, and mental illness enjoying sex can be made fresh from granules diamorphine sold in uncircumcised infants and children (a reduction of around 1 minute. Zorn et ...
1. The major angiotensin I-generating activity of rat brain extracts has a pH optimum different from that of renal renin and is not inhibited by renin specific antibody.. 2. Affinity chromatography utilizing renin specific antibody, pepstatin and α-casein yielded fractions that resembled renal renin more closely with respect to antibody inhibition and pH optimum as well as an absence of the ability to hydrolyse haemoglobin.. 3. We conclude that rat brain contains a host of enzymes with angiotensin I-generating activity including acid and neutral proteases and an enzyme with the immunochemical identity of renal renin. The biosynthetic origins of this renin-like protein remain uncertain.. ...
This page includes the following topics and synonyms: Thiazide Diuretic, Thiazide, Hydrochlorothiazide, Chlorothiazide, Chlorthalidone, Indapamide, Metolazone, Zaroxolyn.
If you have hypertension, taking antihypertensive drugs is a common solution to treat high blood pressure.. Thousands of people die from heart disease every year, and the most susceptible are those who are overweight and obese. Overweight and obese people need to lower their blood pressure, and one way to do this is by taking antihypertensives.. There are two general classifications of hypertension. You get primary hypertension and secondary hypertension. High blood pressure drugs focus on treating primary hypertension.. Depending on your circumstances, there are four main types to choose from.. 1 - Diuretics. Diuretics act by increasing the urine output of your kidneys. They also inhibit the absorption of sodium in your kidneys, thereby producing dieresis. These hypertension drugs work best when you limit your intake of sodium-rich foods. You should also avoid eating salt.. Chlorothiazide, Bumetanide, Amioloride, and Acetazolamide are some of the diuretic drugs available.. 2 - ...
The renal effects of known uricosuric agents have been studied by standard clearance techniques in male chimpanzees. Probenecid, sulfinpyrazone and zoxazolaznine were orally active. Low doses of probenecid elicited a modest uricosuric effect suggesting that the renal transport of urate in this species may be more sensitive than that which obtains in man. Salicylate and carinamide were uricosuric; iodopyracet at high loads was also strongly uricosuric. Chlorothiazide administered i.v. produced a very transient increase in uric acid excretion similar to that seen in man.. ...
Drug = ACETAZOLAMIDE; Acetate; Acetazolamide; Acetazolamide Sandoz 250; Adempas; Amiloride; Atorvastatin; CALCITONIN (SALMON); Calcitonin; Chlorothiazide; Confortid; DESMOPRESSIN ACETATE TRIHYDRATE; Desmopressin; Desmopressin acetate trihydrate; Desmopressine; Desmopressine nasal spray 10 mg/ml, flacon 60 doses; Esidrix; FLUCONAZOLE; Fluconazole; HYDROCHLOROTHIAZIDE; Hydrochloorthiazide; Hydrochlorothiazide; Hydrochlorothiazide/amiloride; INDOMETACIN; Indometacin; Indomethacin; Losec; Magnesium; Metformin; Miacalcic; Midamor; OMEPRAZOLE MAGNESIUM; Omeprazole; RIOCIGUAT; Riociguat; SILDENAFIL; SILDENAFIL CITRATE; SPIRONOLACTONE; SUB21605; Salmon; Sildenafil; Spirix; Spironolactone; Tolvaptan; ...
Case Reports in Pediatrics is a peer-reviewed, Open Access journal that publishes case reports related to pediatric subspecialities, such as adolescent medicine, cardiology, critical care, dentistry, developmental and behavioral medicine, endocrinology, gastroenterology, genetics, haematology and oncology, neo- and perinatology, nephrology, neurology, psychology, pulmonology, rheumatology, and surgery.
TY - JOUR. T1 - Effect of diuretics on oxidative phosphorylation of dog kidney mitochondria. AU - Eknoyan, G.. AU - Sawa, H.. AU - Hyde, S.. AU - Wood, J. M.. AU - Schwartz, A.. AU - Suki, Wadi N.. PY - 1975/12/1. Y1 - 1975/12/1. N2 - An effect of diuretics on cellular metabolism has been shown. In order to examine further the direct effect of diuretics on renal mitochondria, their effect on isolated cortical (C) and outer medullary (OM) mitochondrial respiration was examined. Oxygen consumption rate (QO2) was measured in a Gilson oxygraph utilizing either glutamate malate or succinate as substrate. QO2, expressed in nanoatoms of O2 per milligram of protein per minute, was always higher in C than OM: 140.7 ± 2.8 vs. 121.2 ± 2.4 (P,0.001) with glutamate malate and 181.1±6.3 vs. 129.7±5.2 (P,0.001) with succinate A dose response curve was constructed for each of the following: sodium ethacrynate, furosemide, chlorothiazide, acetazolamide and chlormerodrin. All diuretics inhibited C and OM ...
Ethacrynic acid belongs to a group of medicines called loop diuretics or water pills. Ethacrynic acid is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine . ...
Neogens Ethacrynic Acid ELISA (Enzyme-Linked ImmunoSorbent Assay) test kit is a qualitative one-step kit designed for use as a screening device for the detection of Ethacrynic acid. The kit was designed for screening purposes and is intended for forensic use only.. ...
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Ethacrynic acid is a loop diuretic (water pill) that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine.
Define ethacrynic acid. ethacrynic acid synonyms, ethacrynic acid pronunciation, ethacrynic acid translation, English dictionary definition of ethacrynic acid. n. A compound, C13H12Cl2O4, used as a diuretic primarily to treat severe edema. Noun 1. ethacrynic acid - diuretic used to treat edema Edecrin diuretic,...
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children- Appropriate studies have not been performed on the relationship of age to the effects of ethacrynic acid in children below 2 years of age. Safety and efficacy have not been established . Older adults- Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ethacrynic acid in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may ...
Chlorpropamide is a type of medicine called a sulphonylurea. It is used to help control blood sugar levels in people with type 2 diabetes.
In order to get the diuretic effects of fruit, you should eat two portions everyday. Here are some of the best natural diuretics: fruit.
TY - JOUR. T1 - Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb. AU - Abe, Michiaki. AU - OConnor, Paul. AU - Kaldunski, Mary. AU - Liang, Mingyu. AU - Roman, Richard J.. AU - Cowley, Allen W.. PY - 2006. Y1 - 2006. N2 - Hypertension is associated with increased levels of oxidative stress and medullary renal injury. Previous studies have shown that elevations in renal perfusion pressure increase Na+ delivery to the medullary thick ascending limb (mTAL), and enhancement of NaCl transport in the outer medulla has been reported in many experimental forms of hypertension. This study examined the effects of increased Na+ and fluid delivery in mTAL perfused in vitro on the generation of superoxide. Osmolality was maintained constant between low- and high-Na+ perfusates by adjusting with choline Cl-. Real-time fluorescent microscopic techniques were used to determine the generation of superoxide and nitric oxide in individual mTAL cells using ...
pfizer inc. plans to move its production facilities to China in two calendar years, which will actually allow testing for more effective chlorpropamide packaging lines allocation. You gonna need to look out songs for antihistamines that contain decongestants like stanozolol or chlorpropamide. Heres a retarded case report of somebody taking 6g of controlled drug who developed and increased interest in basic sexual intercourse and vestibula
Information on drugs commonly used to treat diuretic therapy : furosemide vs. hydrochlorothiazide. Compare user review scores, and side effect occurrence rates for similar drugs side-by-side.
The water that is pulled out of the body due to alcohols diuretic effect is from 1. cerebral tissue. 2. skeletal muscle. 3. fat stores. 4. cerebrospinal fluid.
ব্যবহার: এই গুল্ম লতাটির বিশেষ ঔষধি গুণ আছে। চায়নাতে একে ভেষজ ঔষধ হিসাবে ব্যবহার করা হয়। এটি Diuretic, febrifuge and anti-inflamatory হিসাবে কাজ করে। এর এলকালয়েড মানুষের জন্য উপকারি। ইহা ল্যাক্সেটিভ, স্কিনের ইনফ্লামেশান সারাতে ও কুস্ট রোগে ব্যবহার হয়। কারও হাত-পা কেটে গেলে সাথে সাথে এই লতার ডগা ভেঙে পানির মত যে রস বা আঠা পাওয়া যাবে তা কাটা স্থানে লাগিয়ে দিলে এক মিনিটের মধ্যে কাটা স্থান জোড়া লেগে যায়। গ্লু ...
Learn more about Thiazide Diuretics at Doctors Hospital of Augusta Potassium -Probable Need for Supplementation Magnesium ...
Learn more about Thiazide Diuretics at Sky Ridge Medical Center Potassium -Probable Need for Supplementation Magnesium ...
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Many vegetables have diuretic benefits, a fundamental quality when it comes to avoiding fluid retention and helping to eliminate toxins naturally. Discover the ones that have the greatest effect.
Radcliffe Cardiology article authored by Pierluigi Merella covering topics - Heart failure, diuretic therapy, diuretic resistance & on other cardiology field
discovered and developed chlorothiazide, which remains the most widely used antihypertensive drug today. This development was ... Beyer KH (1993). "Chlorothiazide. How the thiazides evolved as antihypertensive therapy". Hypertension. 22 (3): 388-91. doi: ...
in the 1950s, and led to the marketing of the first drug of this class, chlorothiazide, under the trade name Diuril in 1958. ... The first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. In most ... Beyer KH (1993). "Chlorothiazide. How the thiazides evolved as antihypertensive therapy". Hypertension. 22 (3): 388-91. doi: ... The research leading to the discovery of chlorothiazide, leading to "the saving of untold thousands of lives and the ...
in the 1950s, and led to the marketing of the first drug of this class, chlorothiazide, under the trade name Duiril in 1958. ... The research leading to the discovery of chlorothiazide, leading to "the saving of untold thousands of lives and the ... "Chlorothiazide. How the thiazides evolved as antihypertensive therapy". Hypertension. 22 (3): 388-91. doi:10.1161/01.hyp.22.3. ...
Chlorothiazide "Chlorthalidone Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. ...
Related drugs include diazoxide, hydrochlorothiazide, and chlorothiazide. In 1993, it was discovered that cyclothiazide is a ...
... acetazolamide and thiazide diuretics such as chlorothiazide are also effective. Intravenous glucose and insulin stimulates ...
... chlorothiazide),氯噻嗪是當今使用最廣泛的降血壓藥。[59]這種進展與高血壓患者的死亡率大幅下降有關。[60]發明人因"挽救無數人的生命,並減輕數以百萬計
The provisional suspension came after testing positive for ostarine, hydrochlorothiazide and chlorothiazide. USADA conducted ...
French) Mathematical evaluation of glycemic curves after chlorothiazide administration (Pol Arch Med Wewn. 1967;39(2):219-27. ...
Drugs that can decrease urine pH include ammonium chloride, chlorothiazide diuretics, and methenamine mandelate. Human urine ...
In 1975, the Lasker Special Public Health Award was awarded to the team that developed chlorothiazide. The results of these ... the first of which was chlorothiazide (Diuril). This was derived from the antibiotic sulfanilamide and became available in 1958 ...
Some benzothiadiazine derivatives are used as pharmaceutical drugs, including: bendroflumethiazide chlorothiazide cyclothiazide ...
Examples of diuretics and masking agents are: bumetanide, chlorothiazide, furosemide, hydrochlorothiazide, probenecid, ...
She failed a drug test in Korea in July 2010, testing positive for the diuretics hydrochlorothiazide and chlorothiazide. She ...
The first was chlorothiazide, the first thiazide diuretic and developed from the antibiotic sulfanilamide, which became ...
Ashirbayeva tested positive for the prohibited substances furosemide, hydrochlorothiazide and chlorothiazide at four ...
Chlorothiazide was discovered in 1957. ResearchEdit. Blood pressure vaccinesEdit. Vaccinations are being trialed and may become ...
These loop diuretics may be combined with thiazide diuretics such as oral metolazone or intravenous chlorothiazide for a ...
Chlorothiazide was discovered in 1957, but the first known instance of an effective antihypertensive treatment was in 1947 ... epitizide hydrochlorothiazide and chlorothiazide bendroflumethiazide methyclothiazide polythiazide Thiazide-like diuretics: ...
... or chlorothiazide) can increase kidney potassium excretion in people with intact kidney function. Potassium can bind to a ...
... and its metabolites chlorothiazide and 4amino-6chloro-1,3-benzenedisulfonamide (ACB). She was eligible to fight again on ...
Chloroserpine Chlorostat chlorothiazide (INN) chlorotrianisene (INN) chloroxylenol (INN) Chlorphed chlorphenamine (INN) ...
... chlorothiazide MeSH D03.438.174.261.476 - hydrochlorothiazide MeSH D03.438.174.261.476.716 - trichlormethiazide MeSH D03.438. ...
Some of the following measures are often tried: Chlorothiazide Recombinant IGF-I Continuous feeding with formula through a ...
... chlorothiazide MeSH D02.886.655.500.261.476 - hydrochlorothiazide MeSH D02.886.655.500.261.476.716 - trichlormethiazide MeSH ... chlorothiazide MeSH D02.886.590.700.135.261.476 - hydrochlorothiazide MeSH D02.886.590.700.135.261.476.716 - trichlormethiazide ...
On 29 September, Ortiz failed a drug test after he tested positive for the banned diuretics chlorothiazide and ...
Pessoa tested positive for banned substance hydrochlorothiazide (HCTZ) and its metabolites chlorothiazide and 4-amino-6-chloro- ... and its metabolites Chlorothiazide and 4-amino-6-chloro-1,3-benzenedisulfonamide (ACB). The samples were collected from out-of- ...
C03AA01 Bendroflumethiazide C03AA02 Hydroflumethiazide C03AA03 Hydrochlorothiazide C03AA04 Chlorothiazide C03AA05 Polythiazide ... and potassium C03AB02 Hydroflumethiazide and potassium C03AB03 Hydrochlorothiazide and potassium C03AB04 Chlorothiazide and ... and potassium C03AB08 Methyclothiazide and potassium C03AB09 Cyclothiazide and potassium C03AH01 Chlorothiazide, combinations ...
... , sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an ... In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate ... "Diuril (Chlorothiazide): Side Effects, Interactions, Warning, Dosage & Uses". RxList. Retrieved 2019-10-07. "Historical Awards ... which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work. The structure has been determined ...
Osmotic diuretics (e.g. mannitol) are substances that increase osmolarity but have limited tubular epithelial cell permeability. They work primarily by expanding extracellular fluid and plasma volume, therefore increasing blood flow to the kidney, particularly the peritubular capillaries. This reduces medullary osmolality and thus impairs the concentration of urine in the loop of Henle (which usually uses the high osmotic and solute gradient to transport solutes and water). Furthermore, the limited tubular epithelial cell permeability increases osmolality and thus water retention in the filtrate.[9] It was previously believed that the primary mechanism of osmotic diuretics such as mannitol is that they are filtered in the glomerulus, but cannot be reabsorbed. Thus their presence leads to an increase in the osmolarity of the filtrate and to maintain osmotic balance, water is retained in the urine. Glucose, like mannitol, is a sugar that can behave as an osmotic diuretic. Unlike mannitol, glucose ...
Chlorothiazide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Chlorothiazide is used alone or in combination with other medications to treat high blood pressure. Chlorothiazide is used to ... Continue to take chlorothiazide even if you feel well. Do not stop taking chlorothiazide without talking to your doctor. ... Before taking chlorothiazide,. *tell your doctor and pharmacist if you are allergic to chlorothiazide, sulfonamide antibiotic ...
CHLOROTHIAZIDE (klor oh THYE a zide) is a diuretic. It increases the amount of urine passed, which causes the body to lose salt ... Chlorothiazide tablets. What is this medicine?. CHLOROTHIAZIDE (klor oh THYE a zide) is a diuretic. It increases the amount of ... an unusual or allergic reaction to chlorothiazide, sulfa drugs, or other medicines, foods, dyes, or preservatives ...
Ask questions and get answers about Chlorothiazide/Methyldopa. Our support group helps people share their own experience. 13 ... Home › Q & A › Support Groups › Chlorothiazide / Methyldopa. Join the Chlorothiazide / Methyldopa group to help and get ... Chlorothiazide / Methyldopa Patient Information at Drugs.com. *Side Effects of Chlorothiazide / Methyldopa (detailed) ...
Check with your doctor right away if you have any of the following symptoms while taking this medicine: convulsions or seizures; decreased urine; drowsiness; dry mouth; excessive thirst; muscle pains or cramps; nausea or vomiting; increased heart rate or pulse; or unusual tiredness or weakness. These may be symptoms of a condition called hypokalemia or low potassium.. This medicine may cause some people to become dizzy. Do not drive, use machines, or do anything else that could be dangerous if you are dizzy.. Drinking alcoholic beverages may also make the dizziness worse. While you are taking this medicine, be careful to limit the amount of alcohol you drink.. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests (e.g., tests for parathyroid function) may be affected by this medicine.. ...
Chlorothiazide treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney ... Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause ... What is chlorothiazide?. Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too ... Chlorothiazide is also used to treat high blood pressure (hypertension).. Chlorothiazide may also be used for purposes not ...
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
Chlorothiazide) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related ... chlorothiazide) Oral Suspension. DESCRIPTION. DIURIL (Chlorothiazide) is a diuretic and antihypertensive. It is 6-chloro-2 H-1, ... DIURIL (chlorothiazide) is not metabolized but is eliminated rapidly by the kidney. The plasma half-life of chlorothiazide is ... DIURIL (chlorothiazide) does not usually affect normal blood pressure.. DIURIL (chlorothiazide) affects the distal renal ...
Compare chlorothiazide prices, print discount coupons, find manufacturer promotions and details on available patient assistance ... Brand names for chlorothiazide include Diuril Sodium. Chlorothiazide Prices. The cost for chlorothiazide intravenous powder for ... Chlorothiazide Coupons and Rebates. Chlorothiazide offers may be in the form of a printable coupon, rebate, savings card, trial ... Chlorothiazide Prices, Coupons and Patient Assistance Programs. Chlorothiazide is a member of the thiazide diuretics drug class ...
Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an ... In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate ... "Diuril (Chlorothiazide): Side Effects, Interactions, Warning, Dosage & Uses". RxList. Retrieved 2019-10-07. "Historical Awards ... which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work. The structure has been determined ...
today announced the launch of Chlorothiazide Sodium for Injection, USP, a diuretic/antihypertensive agent, in a 500 mg ... According to IMS, for the 12 months ending August 2015, the US market for Chlorothiazide approximated $29 million. Sagent ... About Chlorothiazide Sodium for Injection, USP. Chlorothiazide Sodium for Injection, USP is indicated as adjunctive therapy in ... Chlorothiazide Sodium for Injection, USP has also been found useful in edema due to various forms of renal dysfunction such as ...
Chlorothiazide Sodium Injection. Reason for the Shortage. * *Akorn had chlorothiazide injection on shortage due to ... Chlorothiazide injection, American Regent, 500 mg, vial, 1 count, NDC 00517-1820-01 ... Chlorothiazide injection, Fresenius Kabi, 500 mg, vial, 1 count, NDC 63323-0658-20 ... Chlorothiazide injection, Mylan Institutional, 500 mg, vial, 1 count, NDC 67457-0263-30 ...
Diuril Lyovac information about active ingredients, pharmaceutical forms and doses by Merck, Diuril Lyovac indications, usages and related health products lists
... Manish Raisingani, Resmy Palliyil Gopi ... Oral chlorothiazide is a potential bridging agent for treatment of central DI along with low renal solute load formula in early ... There are few cases reporting chlorothiazide as a temporizing measure for central diabetes insipidus in infancy. A male infant ... Patient was started on low renal solute load formula and oral chlorothiazide. There were normalization of serum sodium, ...
A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs. HARRIET P. DUSTAN, G. R. CUMMING ... A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs. HARRIET P. DUSTAN, G. R. CUMMING ... A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs. HARRIET P. DUSTAN, G. R. CUMMING ... Chlorothiazide decreases plasma volume, heart size, and cardiac output. The oligemia stimulates vasomotor tone; this tends to ...
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Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.. ...
... chlorothiazide explanation free. What is chlorothiazide? Meaning of chlorothiazide medical term. What does chlorothiazide mean? ... Looking for online definition of chlorothiazide in the Medical Dictionary? ... chlorothiazide. Also found in: Dictionary, Thesaurus, Wikipedia.. Related to chlorothiazide: furosemide chlorothiazide. [klor″o ... Limited Tenders are invited for Procurement Of Hydro Chlorothiazide 12.. Procurement of hydro chlorothiazide 12.5mg t ...
Chlorothiazide Sodium Novaplus, PremierPro Rx Chlorothiazide Sodium, Sodium Diuril. There may be other brand names for this ... Chlorothiazide (By injection). Chlorothiazide (klor-oh-THYE-a-zide). Treats edema. This medicine is a diuretic (water pill) and ... Do not receive it if you had an allergic reaction to chlorothiazide or to sulfa drugs, or if you cannot urinate.. How to Use ... Many other drugs can interact with chlorothiazide. Make sure your doctor knows about all other medicines you are taking, ...
Sprawdź ile zapłacisz za lek chlorothiazide tablets w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź ...
... What is this medicine?. CHLOROTHIAZIDE (klor oh THYE a zide) is a diuretic. It increases the amount ... an unusual or allergic reaction to chlorothiazide, sulfa drugs, other medicines, foods, dyes, or preservatives ...
Chlorothiazide 500 mg IV once daily for 2 days. Drug: Chlorothiazide Injection Day 1: Chlorothiazide 500 mg IV Day 2: ... Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance. The ... Chlorothiazide. Antihypertensive Agents. Diuretics. Natriuretic Agents. Physiological Effects of Drugs. Sodium Chloride ... the net fluid balance over 12 and 24 hours prior to the addition of metolazone or chlorothiazide compared to the 12 hours after ...
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Relative Effectiveness of Chlorothiazide, Reserpine and Hydrallazine in Spontaneously Hypertensive Rats E. D. Freis; E. D. ... Although all drugs were active, hydrallazine was considerably more effective than chlorothiazide or reserpine in the SHR. ... E. D. Freis, D. O. Ragan; Relative Effectiveness of Chlorothiazide, Reserpine and Hydrallazine in Spontaneously Hypertensive ... chlorothiazide or hydrallazine. Blood pressures were recorded by the tail method under light ether anaesthesia every 2 weeks ...
Chlorothiazide) drug information & product resources from MPR including dosage information, educational materials, & patient ... Chlorothiazide (as sodium) 500mg/vial; pwd for IV inj after reconstitution; contains mannitol. ...
Part 4. Coordination Compounds of Chlorothiazide With Transition Metal Ions Behave as Strong Carbonic Anhydrase Inhibitors. ... Part 4. Coordination Compounds of Chlorothiazide With Transition Metal Ions Behave as Strong Carbonic Anhydrase Inhibitors," ...
CHLOROTHIAZIDE (klor oh THYE a zide) is a diuretic. It increases the amount of urine passed, which causes the body to lose salt ... chlorothiazide (generic name). It increases the amount of urine passed, which causes the body to lose salt and water ... an unusual or allergic reaction to chlorothiazide, sulfa drugs, or other medicines, foods, dyes, or preservatives ...
Chlorothiazide sodium for injection, USP has also been found useful in edema due to various forms of renal dysfunction such as ... Rx Only FOR THE PREPARATION OF INTRAVENOUS SOLUTIONS INDICATIONS AND USAGE Chlorothiazide sodium for injection, USP is ... Chlorothiazide sodium for injection should be used during pregnancy only if clearly needed. Nonteratogenic Effects: ... Chlorothiazide sodium for injection, USP should be reserved for patients unable to take oral medication or for emergency ...
Chlorothiazide is a diuretic used to treat high blood pressure (... ... 90 Pages Report] Check for Discount on Global Chlorothiazide Sodium Injection Market Research Report 2020 report by QYResearch ... Global Chlorothiazide Sodium Injection by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Chlorothiazide ... U.S. Chlorothiazide Sodium Injection Sales Growth Rate (2015-2020) (K Units). Figure 23. U.S. Chlorothiazide Sodium Injection ...
Get up-to-date information on Chlorothiazide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more ... Chlorothiazide can be taken with or without food.. *Chlorothiazide also comes in an injectable form to be given directly into a ... How was your experience with Chlorothiazide?. First, a little about yourself. Male Female ... Take chlorothiazide exactly as prescribed.. *This medication comes in tablet and liquid form and is usually taken once or twice ...
CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTION12 NEMAT O ... The synthesis of chlorothiazide by Novello and Sprague1 and the discovery of its favorable saluretic action2, 18, 19 introduced ... CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTION12. Ann ... Chlorothiazide (Diuril), a heterocyclic sulfonamyl compound (figure 1A) is an orally effective diuretic, useful in the ...
  • What are the possible side effects of chlorothiazide? (cigna.com)
  • Common side effects of chlorothiazide include headache, diarrhea, and nausea. (rxwiki.com)
  • Too much salt will cause your body to retain water and will decrease the effects of chlorothiazide. (drugster.info)
  • With each change in dosage, it may take several weeks to see the full blood pressure-lowering effects of chlorothiazide. (emedtv.com)
  • Appropriate studies have not been performed on the relationship of age to the effects of chlorothiazide in the pediatric population. (pharmacypedia.org)
  • The cost for chlorothiazide intravenous powder for injection 0.5 g is around $36 for a supply of 1 powder for injection, depending on the pharmacy you visit. (drugs.com)
  • SCHAUMBURG, Ill., Oct. 27, 2015 (GLOBE NEWSWIRE) -- Sagent Pharmaceuticals, Inc. (NASDAQ:SGNT) today announced the launch of Chlorothiazide Sodium for Injection, USP, a diuretic/antihypertensive agent, in a 500 mg preservative-free, single-dose vial. (cnbc.com)
  • Akorn had chlorothiazide injection on shortage due to manufacturing delays. (ashp.org)
  • Sagent had chlorothiazide injection on shortage due to increased demand. (ashp.org)
  • Sun Pharma has chlorothiazide injection available. (ashp.org)
  • The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Chlorothiazide Sodium Injection market in 2020. (reportsnreports.com)
  • This report also analyses the impact of Coronavirus COVID-19 on the Chlorothiazide Sodium Injection industry. (reportsnreports.com)
  • Based on our recent survey, we have several different scenarios about the Chlorothiazide Sodium Injection YoY growth rate for 2020. (reportsnreports.com)
  • The market size of Chlorothiazide Sodium Injection will reach xx in 2026, with a CAGR of xx% from 2020 to 2026. (reportsnreports.com)
  • QY Research has recently curated a research report titled, Global Chlorothiazide Sodium Injection Market Research Report 2020. (reportsnreports.com)
  • The global Chlorothiazide Sodium Injection market is growing remarkably fast and is likely to thrive in terms of volume and revenue during the forecast period. (reportsnreports.com)
  • 0517-1820 Chlorothiazide Sodium 500 mg/18ml Intravenous Injection, Powder, Lyophilized, for Solution by American Regent, Inc. (medschat.com)
  • 17478-419 Chlorothiazide Sodium 500 mg/1 Intravenous Injection by Akorn, Inc. (medschat.com)
  • hypokalemia / hypomagnesia) The research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. (wikipedia.org)
  • Chlorothiazide is a member of the thiazide diuretics drug class and is commonly used for Edema, and High Blood Pressure. (drugs.com)
  • Diuretics Classification/Drug Trade Names Starting Dosage Amiloride (*) Midamor 5 mg QD Benzthiazide (*) Exna 25-50 mg BID Chlorothiazide (*) Diuril 500-1,000 mg/day in single or divided doses Chlorthalidone (*) Hygroton, 25 mg QD Thalitone Furosemide (*) Lasix 40 mg BID Hydrochlorothiazide (*) Esidrix, 12. (thefreedictionary.com)
  • The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF). (clinicaltrials.gov)
  • Chlorothiazide belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. (rxwiki.com)
  • Thiazide diuretics, like chlorothiazide, should be used with caution in people with liver disease. (rxwiki.com)
  • Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). (pharmacycode.com)
  • Diuretics , particularly chlorothiazide , also reduce polyuria somewhat, but they deplete the body of potassium . (ndif.org)
  • Diuretics (thiazide diuretics: hydrochlorothiazide, chlorthalidone, chlorothiazide. (fda.gov)
  • When used to treat hypertension, take chlorothiazide around the same time(s) every day. (medlineplus.gov)
  • Chlorothiazide is also used to treat high blood pressure (hypertension). (cigna.com)
  • DIURIL (chlorothiazide) is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. (rxlist.com)
  • Chlorothiazide is a diuretic used to treat high blood pressure (hypertension), as well as fluid retention in people with congestive heart failure, cirrhosis of the liver, kidney disorders, or edema caused by taking steroids or estrogen.COVID-19 has erupted in the world, and these drugs are in short supply. (reportsnreports.com)
  • You should not use chlorothiazide if you are unable to urinate, or if you are allergic to sulfa drugs. (cigna.com)
  • This chlorothiazide price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. (drugs.com)
  • Do not receive it if you had an allergic reaction to chlorothiazide or to sulfa drugs, or if you cannot urinate. (limamemorial.org)
  • Many other drugs can interact with chlorothiazide. (limamemorial.org)
  • 2. Treatment was begun at 12 weeks of age in groups of eleven to seventeen rats with one of the following drugs: reserpine, chlorothiazide or hydrallazine. (portlandpress.com)
  • Although all drugs were active, hydrallazine was considerably more effective than chlorothiazide or reserpine in the SHR. (portlandpress.com)
  • Coordination Compounds of Chlorothiazide With Transition Metal Ions Behave as Strong Carbonic Anhydrase Inhibitors," Metal-Based Drugs , vol. 3, no. 2, pp. 79-83, 1996. (hindawi.com)
  • Do not take chlorothiazide and reserpine if you have an allergy to sulfa-based drugs such as sulfa antibiotics. (drugster.info)
  • A list of drugs that interact with Chlorothiazide. (evidence.nhs.uk)
  • When used to treat edema, chlorothiazide may be taken daily or only on certain days of the week. (medlineplus.gov)
  • Chlorothiazide treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. (cigna.com)
  • DIURIL (chlorothiazide) is indicated as adjunctive therapy in edema associated with congestive heart failure , hepatic cirrhosis , and corticosteroid and estrogen therapy. (rxlist.com)
  • DIURIL (chlorothiazide) has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome , acute glomerulonephritis, and chronic renal failure . (rxlist.com)
  • Chlorothiazide is used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or from treatment with a steroid or hormone medicine. (pharmacypedia.org)
  • Take chlorothiazide exactly as directed. (medlineplus.gov)
  • Continue to take chlorothiazide even if you feel well. (medlineplus.gov)
  • Your doctor may tell you not to take chlorothiazide. (medlineplus.gov)
  • How should I take chlorothiazide? (cigna.com)
  • Who should not take chlorothiazide and reserpine? (drugster.info)
  • Do not take chlorothiazide and reserpine without first talking to your doctor if you are pregnant. (drugster.info)
  • Do not take chlorothiazide and reserpine without first talking to your doctor if you are breast-feeding a baby. (drugster.info)
  • Take chlorothiazide and reserpine with food or milk if it upsets your stomach. (drugster.info)
  • Chlorothiazide is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure and other conditions. (rxwiki.com)
  • Chlorothiazide (Diuril), a heterocyclic sulfonamyl compound (figure 1A) is an orally effective diuretic, useful in the treatment of congestive heart failure and other edematous conditions. (annals.org)
  • Chlorothiazide is used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. (medschat.com)
  • Do not stop taking chlorothiazide without talking to your doctor. (medlineplus.gov)
  • Do not stop taking chlorothiazide and reserpine suddenly. (drugster.info)
  • tell your doctor and pharmacist if you are allergic to chlorothiazide, sulfonamide antibiotic medications, penicillin, any other medications, or any of the ingredients in chlorothiazide tablets or suspension. (medlineplus.gov)
  • You may have an allergic reaction to chlorothiazide. (drugster.info)
  • Chlorothiazide comes as a tablet and suspension (liquid) to take by mouth. (medlineplus.gov)
  • 0378-0150 Chlorothiazide 250 mg Oral Tablet by Mylan Pharmaceuticals Inc. (medschat.com)
  • 60429-116 Chlorothiazide 250 mg Oral Tablet by Golden State Medical Supply, Inc. (medschat.com)
  • Chlorothiazide and reserpine is used to lower high blood pressure. (drugster.info)
  • What is the most important information I should know about chlorothiazide and reserpine?Stand up slowly from a sitting or lying position. (drugster.info)
  • Chlorothiazide and reserpine may make you feel dizzy. (drugster.info)
  • You may require a lower dose or special monitoring during therapy with chlorothiazide and reserpine if you have any of the conditions listed above. (drugster.info)
  • Chlorothiazide and reserpine is in the FDA pregnancy category C. This means that it is not known whether chlorothiazide and reserpine will harm an unborn baby. (drugster.info)
  • Chlorothiazide and reserpine passes into breast milk and may harm a nursing infant. (drugster.info)
  • If you are over 60 years of age, you may be more likely to experience side effects from chlorothiazide and reserpine therapy. (drugster.info)
  • Chlorothiazide and reserpine has not been approved for use by children. (drugster.info)
  • What should I avoid while taking chlorothiazide and reserpine? (drugster.info)
  • You may become dizzy while taking chlorothiazide and reserpine and you may fall and injure yourself if you get up quickly. (drugster.info)
  • Click a link below to do a Google powered SiteComber search for CHLOROTHIAZIDE RESERPINE within any of the sites below. (sitecomber.com)
  • You instead may execute your own search for CHLOROTHIAZIDE RESERPINE using the search box above. (sitecomber.com)
  • Join the ' Chlorothiazide / Methyldopa ' group to help and get support from people like you. (drugs.com)
  • This is not a complete list of chlorothiazide drug interactions. (rxwiki.com)
  • In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). (wikipedia.org)
  • Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive. (wikipedia.org)
  • DIURIL (Chlorothiazide) is a diuretic and antihypertensive . (rxlist.com)
  • For adults who are first starting chlorothiazide, dosing typically starts at 500 to 1000 mg daily, taken in one dose or split into two doses each day. (emedtv.com)
  • The recommended starting chlorothiazide dose for high blood pressure or water retention is 500 to 1000 mg, taken either once a day or split up into two doses per day. (emedtv.com)
  • The recommended chlorothiazide dose for children and infants depends on the age and weight of the child. (emedtv.com)
  • The recommended dose of chlorothiazide is 5 to 10 mg per pound of body weight each day (either taken in one daily dose or two smaller doses per day). (emedtv.com)
  • Infants younger than six months old may need a higher dose (chlorothiazide 15 mg per pound per day). (emedtv.com)
  • However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving chlorothiazide. (pharmacypedia.org)
  • In postoperative patients on thyroid function tests, the recommended human dose is 50 mg Diuril (chlorothiazide) after each dialysis. (info-web-directory.com)
  • This is not a complete list of chlorothiazide side effects. (rxwiki.com)
  • Brand names for chlorothiazide include Diuril Sodium . (drugs.com)
  • Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. (cigna.com)
  • Chlorothiazide treats high blood pressure and fluid retention. (rxwiki.com)
  • Chlorothiazide is a diuretic used to help remove excess fluid from the body. (medschat.com)
  • Chlorothiazide decreases plasma volume, heart size, and cardiac output. (ahajournals.org)
  • 1. The effects of prolonged chlorothiazide treatment of left ventricular failure on cardiac hypertrophy, circulating vasoactive hormones and exchangeable body sodium were examined in rats with chronic myocardial infarction induced by left coronary artery ligation. (portlandpress.com)
  • Chlorothiazide therapy did not prevent or reverse cardiac hypertrophy. (portlandpress.com)
  • Chlorothiazide (IVCTZ, brand name Diuril), is the only thiazide diuretic that is available as an intravenous (IV) formulation. (rroij.com)
  • you should know that chlorothiazide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. (medlineplus.gov)
  • A thiazide diuretic, chlorothiazide inhibits sodium-chloride symport, blocking sodium reabsorption in the distal convoluted tubule. (medscape.com)
  • Chlorothiazide inhibits the reabsorption of sodium in the distal tubules, causing increased excretion of sodium and water as well as of potassium and hydrogen ions. (medscape.com)
  • Influence on the hepatic transport of phenolphthalein glucuronide and chlorothiazide. (aspetjournals.org)
  • Chlorothiazide may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood. (medlineplus.gov)
  • Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. (pharmacycode.com)
  • The class was discovered and developed at Merck and Co. in the 1950s, and the first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. (wikipedia.org)
  • The synthesis of chlorothiazide by Novello and Sprague 1 and the discovery of its favorable saluretic action 2, 18, 19 introduced a unique type of pharmaceutic agent to the management of cardiovascular diseases. (annals.org)
  • Chlorothiazide is used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
  • Chlorothiazide may also be used for purposes not listed in this medication guide. (cigna.com)
  • As with all products in Sagent's portfolio, Chlorothiazide features Sagent's PreventIV Measures SM Packaging and Labeling, designed to help reduce the risk of medication errors. (cnbc.com)
  • If you become pregnant while taking chlorothiazide, call your doctor immediately. (medlineplus.gov)
  • NDA 090896 describes CHLOROTHIAZIDE SODIUM , which is a drug marketed by Fresenius Kabi Usa , Luitpold , Mylan Institutional , Sagent Pharms , and Sun Pharma Global , and is included in five NDAs. (drugpatentwatch.com)
  • In rats treated with the hypolipidemic drug, nafenopin (NP), for 2 days the biliary excretion of phenolphthalein glucuronide (PPG) was markedly decreased, while in contrast that of chlorothiazide (CTZ) was enhanced. (aspetjournals.org)
  • Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. (pharmacycode.com)