8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.

A monooxygenase catalyzes sequential dechlorinations of 2,4,6-trichlorophenol by oxidative and hydrolytic reactions. (1/10)

Ralstonia eutropha JMP134 2,4,6-trichlorophenol (2,4,6-TCP) 4-monooxygenase catalyzes sequential dechlorinations of 2,4,6-TCP to 6-chlorohydroxyquinol. Although 2,6-dichlorohydroxyquinol is a logical metabolic intermediate, the enzyme hardly uses it as a substrate, implying it may not be a true intermediate. Evidence is provided to support the proposition that the monooxygenase oxidized 2,4,6-TCP to 2,6-dichloroquinone that remained with the enzyme and got hydrolyzed to 2-chlorohydroxyquinone, which was chemically reduced by ascorbate and NADH to 6-chlorohydroxyquinol. When the monooxygenase oxidized 2,6-dichlorophenol, the product was 2,6-dichloroquinol, which was not further converted to 6-chlorohydroxyquinol, implying that the enzyme only converts 2,6-dichloroquinone to 6-chlorohydroxyquinol. Stoichiometric analysis indicated the consumption of one O2 molecule per 2,4,6-TCP converted to 6-chlorohydroxyquinol, ruling out the possibility of two oxidative reactions. Experiments with 18O-labeling gave direct evidence for the incorporation of oxygen from both O2 and H2O into the produced 6-chlorohydroxyquinol. A monooxygenase that catalyzes hydroxylation by both oxidative and hydrolytic reactions has not been reported to date. The ability of the enzyme to perform two types of reactions is not due to the presence of a second functional domain but rather is due to catalytic promiscuity, as a homologous monooxygenase converts 2,4,6-TCP to only 2,6-dichloroquinol. Employing both conventional catalysis and catalytic promiscuity of a single enzyme in two consecutive steps of a metabolic pathway has been unknown previously.  (+info)

A novel dual antagonist of thromboxane A2 and leukotriene D4 receptors: synthesis and structure-activity relationships of chloroquinolylvinyl derivatives. (2/10)

To discover an orally active thromboxane A(2) (TXA(2)) and leukotriene D(4) (LTD(4)) dual antagonist, we designed and synthesized chloroquinolylvinyl derivatives based on the structures of the TXA(2) antagonist daltroban and the LTD(4) antagonist montelukast. Among these derivatives, 4-{[(2-(4-chlorophenylsulfonylamino)-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]pheny l}ethyl)thio]methyl}benzoic acid (18d) showed potent inhibitory activity against U46619-induced aggregation of guinea pig platelets and LTD(4)-induced contraction in the guinea pig ileum, with IC(50) values of 340 nm and 0.40 nm, respectively. Oral administration of 18 d also inhibited both the LTD(4)-induced acceleration of plasma leakage to skin in guinea pig and the U46619-induced increase in airway resistance in guinea pig with ED(50) values of 0.47 mg/kg and 3.3 mg/kg, respectively.  (+info)

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis. (3/10)

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.  (+info)

Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. (4/10)

In subjects with schizophrenia, impairments in working memory are associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be due, at least in part, to abnormalities in gamma-aminobutyric acid (GABA)-mediated inhibitory circuitry. To test the hypothesis that altered GABA-mediated circuitry in the DLPFC of subjects with schizophrenia reflects expression changes of genes that encode selective presynaptic and postsynaptic components of GABA neurotransmission, we conducted a systematic expression analysis of GABA-related transcripts in the DLPFC of 14 pairs of schizophrenia and age-, sex- and post-mortem interval-matched control subjects using a customized DNA microarray with enhanced sensitivity and specificity. Subjects with schizophrenia exhibited expression deficits in GABA-related transcripts encoding (1) presynaptic regulators of GABA neurotransmission (67 kDa isoform of glutamic acid decarboxylase (GAD(67)) and GABA transporter 1), (2) neuropeptides (somatostatin (SST), neuropeptide Y (NPY) and cholecystokinin (CCK)) and (3) GABA(A) receptor subunits (alpha1, alpha4, beta3, gamma2 and delta). Real-time qPCR and/or in situ hybridization confirmed the deficits for six representative transcripts tested in the same pairs and in an extended cohort, respectively. In contrast, GAD(67), SST and alpha1 subunit mRNA levels, as assessed by in situ hybridization, were not altered in the DLPFC of monkeys chronically exposed to antipsychotic medications. These findings suggest that schizophrenia is associated with alterations in inhibitory inputs from SST/NPY-containing and CCK-containing subpopulations of GABA neurons and in the signaling via certain GABA(A) receptors that mediate synaptic (phasic) or extrasynaptic (tonic) inhibition. In concert with previous findings, these data suggest that working memory dysfunction in schizophrenia is mediated by altered GABA neurotransmission in certain DLPFC microcircuits.  (+info)

Reduction of dopamine synaptic activity: degradation of 50-kHz ultrasonic vocalization in rats. (5/10)

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Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by (3)(5)Cl NQR, (1)H-(1)(7)O and (1)H-(1)(4)N NQDR and DFT/QTAIM. (6/10)

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In situ formation of steroidal supramolecular gels designed for drug release. (7/10)

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In vitro activity of chlorhydroxyquinoline against mycoplasma species. (8/10)

The in vitro activities of 5-chloro-8-hydroxyquinoline (CHQ) against single strains of 12 different species of mycoplasma and the impacts of repeated exposure of these strains to CHQ on their susceptibility to this agent have been studied. On initial exposure, the minimal inhibitory concentrations for these strains ranged from 0.24 to 1.92 micrograms of CHQ per ml of test medium; activities remained unchanged during 10 serial transfers in CHQ-containing medium.  (+info)

Tensile and axial fatigue tests were conducted on shallow cryogenically treated EN19 medium carbon alloy steel to investigate its mechanical behavior. The test samples were conventionally heat treated then oil quenched at room temperature. Followed by the samples were kept for shallow cryogenic trea
LONDON -- A British teenager who died of cancer has been cryogenically frozen in the United States after winning a court case before her death. The girl -- who cant be identified and is referred to only as JS -- suffered from a rare form of cancer and expressed a hope to be brought back to...
LONDON -- A British teenager who died of cancer has been cryogenically frozen in the United States after winning a court case before her death. The girl -- who cant be identified and is referred to only as JS -- suffered from a rare form of cancer and expressed a hope to be brought back to lif...
Fellow 90s kids will remember the urban legend surrounding Walt Disneys death: Rumor had it this cartoon king was cryogenically frozen, then interred beneath the Pirates of the Caribbean ride at Disneyland. We all loved the story, believing Walt…
1. Prove Your Doubters WrongFor as long as you can remember, people have been telling you that you could never make it as a static mass of frozen cells ... View 10 Reasons to Cryogenically Freeze Yourself Today! and more funny posts on CollegeHumor
Abstract: Objective(s): In recent years, the chemistry of 2-chloroquinoline-3-carbaldehydes have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity, N1,N4-bis((2-chloroquinolin-3-yl)methylene)benzene-1,4-diamine derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological effects. As the inhibitor of AKT1 (RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1), the aforementioned compounds may have implication in preventing complications of cancers. Materials and Methods: A group of N1, N4-bis ((2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine derivatives (3a-3i) (H, 6-Me, 6-OMe, 6-OEt, 6-Cl, 7-Me, 6-Et, 6-Isopropyl, 7-Cl) were synthesized, and theoretically evaluated for their inhibitory as Potential Human AKT1 Inhibitors via docking process. The docking calculation was done in GOLD 5.2.2 software using Genetic algorithm.Results:
View(58401-43-7)/(4-Chloroquinolin-3-amine)information and document regarding (4-Chloroquinolin-3-amine), including NMR, HPLC, LC-MS, UPLC & more.
SYNTHESIS, IN VITRO ANTIBACTERIAL, TOXICITY AND MOLECULAR DOCKING ANTICANCER ACTIVITY OF NOVEL N-[(2-CHLOROQUINOLIN-3-YL) METHYLIDENE]-2-ANILINE SCHIFFS BASES
6-chloroquinolin-8-amine | C9H7ClN2 | CID 79618 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
This is too long for a comment, so I have to write it in here:. Mostly this is because other cell lines are more practical in the lab.. Stem cells are much more tricky to maintain - especially if you want to keep their stem cell properties. They only grow very slow, tend to differentiate when they get too much stress, cellular signals and so on and need special media (these need to be defined, so that they are not containing factors which promote differentiation for example). For everyday experiments (like expression profiles, experiments on the effects of certain substances on the growth, gene expression or whatever of cells) normal cell lines are much more suited as these are much easier to keep in the lab using standard media. Additionally,experiments can be more easily repeated and reproduced, since these cells should behave always the same.. ...
Inspection of the chemical structure, and experience in the handling and use of the substance, has indicated no properties associated with flammability on contact with water or pyrophoricity. This conclusion is carried forward for use in risk assessment, classification and labeling. The substance failed to sustain a flame in one flammability of solids test. In another test the substance exhibited combustion properties, but with slow propagation. Both tests are considered to be adequate, reliable and relevant. Both support the conclusion the substance is not readily combustable, which is carried forward for use in risk assessment, classification and labeling. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Dimer-catemer synthon 3 in cocrystals 2ClBSA-VLM, 2ClBSA-CPR, OTSA-VLM, PTSA-VLM and two-dimensional hydrogen bond motifs. Two-dimensional packing dia
Gas chromatographic in situ measurements of several C3-C5 hydrocarbons were made for both air, and air equilibrated with surface seawater, during the recent IGAC Aerosol Characterization Experiment (ACE-1). The (approximately hourly) measurements were made from the NOAA ship Discoverer, whose Leg 1 cruise track included a north-south Pacific transit and whose Leg 2 cruise track covered the Southern Ocean from 40S to 55S between 138E and 159E longitude. Measurements were obtained by cryogenically pre-concentrating between 300 and 500 ml of gas drawn from either the bow of the ship or the equilibrator headspace. These measurements show high temporal and spatial variability for concentrations of the non-methane hydrocarbon (NMHC) species observed in both the boundary layer air and surface seawater consistent with previous investigations. Oceanic variability was significantly less than atmospheric variability and the ocean was generally supersaturated with the measured NMHC. Sea-air fluxes have been ...
A new control platform for Sigma Systems cryogenically and mechanically cooled thermal chambers and plates has been introduced by Thermonics. Burn-in and testing of components, sensors, and PCBs typically involves temperature cycling from two to four points, which can be time consuming to set up and run. The new TS Controller provides touch-screen and remote interfacing to set up and transfer thermal profiles, view data and trends, and log diagnostics. Setting up test parameters (from -185 to +500°C) such as set points, ramp speed, hold . . .
Trials to introduce permanent changes in polymers by means of Cryogenic Mechanical Milling (CMM) with the Freezer/Mill® were started with two polymers; isotactic polypropylene (iPP) and syndiotactic polystyrol (sPS). After melting and re-crystallization, both cryogenically ground (i.e.at-196°C) polymers showed characteristics that differ from the original polymers. DSC (Differential Scanning Calorimetry) tests showed changed crystallization temperatures, which indicates reduced molecular weight or a change in molecular weight distribution. The longer the samples were subjected to cryogenic grinding the bigger the change.. Further experiments showed that the crystalline structure is increasingly destroyed during cryogenic grinding. Presumably CMM leads to chain fission and therefore to the formation of macro radicals. This can lead to cross-linking and an increased amorphic content in the partially crystallized polymers. Another explanation would be the formation of nano structures, small ...
Just one more day waiting until I get my life back in the form of a cryogenically frozen bag of my own stem cells. . . . So today is a simple day of getting some saline solution and drinking plenty of fluids to purge any remaining chemo drugs from my body in preparation for the stem cell infusion tomorrow so that the stem cells have the best possible survival and engraftment opportunity. Following the stem cell infusion (either the same day as the infusion, or at sometime after that, depending upon Dr. McClanahans judgement) I will receive a single dose of Neulasta G-CSF. This is really a fantastic drug that promotes stem cell replication, mononuclear cell mobilization and immune recovery to get my immune system back up and healthy at the earliest possible time. Neulasta is a relatively newer G-CSF drug (also an Amgen product just like Neupogen) that has a self-limiting negative reaction coefficiency in which it works constantly and as hard as possible to restore the immune cell function in the ...
Half-hour animated series about a pizza delivery man named Fry who is accidentally cryogenically frozen in 1999 and wakes up 1000 years later to a brave new world--that in some ways hasnt progressed much beyond the 20th century.
A 14-year-old British girl who died of cancer won a landmark court battle in her final days allowing her body to be cryogenically frozen with the aim of bringing her back to life in the future. The girl, who remains unnamed, wrote a heartbreaking letter to the High Court after her divorced parents disagreed over the…
We meet the family who have cryogenically frozen their child in the hopes she may live again once more, and talk to the company behind the controversial process.
Nibbler enlists Fry in a mission to blow up evil brains bent on destroying the universe; Fry time travels into the past to prevent himself from being cryogenically frozen.
BANGKOK, THAILAND - 21 Sep, 2017 - Immune Cells 21 is a leading medical center in Bangkok which specializes in analyzing patients immune system functions with a view of improving them. The results of the analyses are also useful in determining which program would best suit the patients needs. The immune systems primary function is to shield the body from infection and disease, including cancer. Patients with robust immune systems may wish to have their healthy immune cells cryogenically stored for use in the future should their immune systems be compromised by disease.. Traditionally cancer treatment and cancer management has focused on three main methods: surgery, chemotherapy and radiation therapy. These three methods have one major drawback. They tend to be invasive by nature and very often produce aggressive side effects in the body. The cancer patient has to contend not only with the ravages of the disease itself but also with the debilitating side effects of the ...
A method and apparatus for transmural ablation using an instrument containing two electrodes or cryogenic probes. A clamping force is exerted on the two electrodes or probes such that the tissue of the hollow organ is clamped therebetween. Bipolar RF energy is then applied between the two electrodes, or the probes are cryogenically cooled, thus ablating the tissue therebetween. A monitoring device measures a suitable parameter, such as impedance or temperature, and indicates when the tissue between the electrodes has been fully ablated.
The only characteristic that frozen cells share with this definition is the one of organization. For all intents and purposes, a cryogenically frozen organism is dead and lifeless. Navarick says As the cell is thawed, the pre-existing property of life enables biochemical activity to resume.. The enabler is not the pre-existing quality of life but the thawing of the organism. Navaricks cryogenic argument actually bolsters the contention that life is not some unperceptable consequence of a god but rather that life is a product of, and is equivalent to, biochemical activity ...
Princeton Instruments has released PyLoNTM, a new line of controllerless, cryogenically cooled CCD cameras designed for quantitative spectroscopy applications that demand the highest possible sensitivity.. In creating the new PyLoN platform, Princeton redesigned its industry-leading Spec-10 family of cameras to remove the external controller, increasing experimental flexibility while further improving the ultra-low-noise electronics. Liquid nitrogen cooling virtually eliminates dark current, and readout noise has been further reduced from the already low levels in the Spec-10 platform.. PyLoN is available with Princetons unique eXcelon technology which delivers the highest sensitivity in the UV and NIR while suppressing etaloning that occurs in standard back-illuminated deep depletion or back-illuminated CCDs.. The camera includes a GigE interface allowing operation at 4x higher speed than its predecessors, and is supported by Princetons 64-bit LightField software with Intellical wavelength ...
When science allows us to manipulate DNA and choose gender, hair color, sexual orientation, etc. Will you call it evolution then? This is the real question. What will happen when parents elect not to have gay children, or elect to have gay children, red haired children, high IQ children, strong children, etc. will society treat them the same? These are the real questions to face society in our not too distant future. What will the planets people look like in say 150 years? I am glad Im an old guy and wont be around to see it. Unless of course they figure out a way to cryogenically freeze my noggin for later and put it on a young body. Now theres a scary thought ...
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The interaction natures between Pu and different ligands in several plutonyl (VI) complexes are investigated by performing topological analyses of electron density. The geometrical structures in both gaseous and aqueous phases are obtained with B3LYP functional, and are generally in agreement with available theoretical and experimental results when combined with all-electron segmented all-electron relativistic contracted (SARC) basis set. The Pu- O y l bond orders show significant linear dependence on bond length and the charge of oxygen atoms in plutonyl moiety. The closed-shell interactions were identified for Pu-Ligand bonds in most complexes with quantum theory of atoms in molecules (QTAIM) analyses. Meanwhile, we found that some Pu-Ligand bonds, like Pu-OH−, show weak covalent. The interactive nature of Pu-ligand bonds were revealed based on the interaction quantum atom (IQA) energy decomposition approach, and our results indicate that all Pu-Ligand interactions is dominated by the
Craig P. Butts, Michael Green, Thomas N. Hooper, Richard J. Kilby, John E. McGrady, Dimitrios A. Pantazis, Christopher A. Russell, 1,2-Diphosphinobenzene as a synthon for the 1,2,3-triphospha- and 2-arsa-1,3-diphosphaindenyl anions and a stable organo derivative of the P8 unit of Hittorfs phosphorus, Chemical Communications, 2008, 7, ...
Mix oligos (1-16) for one synthon, do PCA1 protocol (453 bp, pca1) PCR pca1 with external oligos (Newfoward and Newreverse) by PCA2 protocol (407 bp, pca2) Digest pca2 with EcoRI/BglII, gp (391+11+5 bp, pcr_dig) (get pre-digested vector from JCA of pBca9145-Bca1144) (EcoRI/BamHI, vect_dig) Ligate pcr_dig and vect_dig Oligo List: ,CCOMT-3_oligo_1 TTTGGAATAGAAACAAACATGTCACCTCCGACATGTTGAGACGATGCAGATCTC ,CCOMT-3_oligo_2 TTCCTTACCACCTGGATTGTGGGCTAACATGATTACGTCAATGTGGACTACAC ,CCOMT-3_oligo_3 TTAGCCCACAATCCAGGTGGTAAGGAAAGAACACAGAAGGAGTTTGAAGACTT ,CCOMT-3_oligo_4 GGCTTTGCCTGATAATGGTAAAGTTATTGTTGCCGAGTGCATTTTACCTGTCG ,CCOMT-3_oligo_5 GGCCAAGGGTGCAGGTTTCCAGGGATTCAAGGTACATTGTAACGCATTTAATA ,CCOMT-3_oligo_6 CTTTAGTTGCTAAAGATGAATCTGGTGCGACAGGTAAAATGCACTCGGCAACA ,CCOMT-3_oligo_7 CTGTCATGATTGGTCTGACGAACATTGCTTGAAATTCTTAAAGAATTGTTATGA ,CCOMT-3_oligo_8 CCTTCTTTAAGAACTCCATAATGTATGTATTAAATGCGTTACAATGTACCTTG ,CCOMT-3_oligo_9 CATACATTATGGAGTTCTTAAAGAAGGTTGGATCCTGAGACCTGAGACGGCAT ,CCOMT-3_oligo_10 ...
Fluvoxamine maleate Synthon is a medicine available in a number of countries worldwide. A list of US medications equivalent to Fluvoxamine maleate Synthon is available on the Drugs.com website.
GABA is formed in the CNS of vertebrate organisms to a large extent, if not entirely, from L-glutamic acid ( Figure 2). The reaction (reaction 5) is catalyzed by L-glutamic acid decarboxylase (GAD), an enzyme found in mammalian organisms largely in neurons in the CNS, although there now are many reports of the occurrence of both GAD and GABA in neurons in the peripheral nervous system, as well as in some nonneural tissues (e.g., pancreas) and in body fluids. Brain GAD catalyzes the rapid \(\alpha\)-decarboxylation of L-glutamic acid and, of the rest of the naturally occurring amino acids, only L-aspartic acid to a very slight extent. Genes for two brain GAD isoforms have been cloned, as have families of other GABA-related proteins, such as 19 GABAA receptors and 2 to 3 GABAB receptors. It now is possible to visualize GABA, itself, and most of the proteins involved in GABA metabolism, release, and action on sections of the CNS at the light and electron microscopic levels, employing antisera to ...
Synthon today announced the initiation of the second part of its ongoing Phase I clinical trial with the investigational anti-HER2 antibody-drug conju
Peptide-bond VUV absorption is inherent to all proteins and peptides. Although widely exploited in top-down proteomics for photodissociation, this absorption has never been spectroscopically characterized in the gas phase. We have measured VUV/UV photofragmentation spectrum of a single peptide bond in a cryogenically cold protonated dipeptide. Although the spectrum appears to be very broadband and structureless, vibrational pre-excitation of this and even larger cold peptides significantly increases the UV dissociation yield for some of their photofragments. We use this effect to extend the technique of IR−UV photofragmentation vibrational spectroscopy, developed for aromatic peptides, to nonaromatic ones and demonstrate measurements of conformation-specific and nonspecific IR spectra for di- to hexa-peptides. Pereverzev, Aleksandr Y.; Kopysov, Vladimir N.; Boyarkin, Oleg V.
MADE IN USA by Jantz Supply in our newly equipped Davis, Oklahoma manufacturing facility using only the best cutlery grade steels available. Each blade is cryogenically processed during the heat treating process for optimal edge holding capabilities ...
The juice itself sparkles with aldehydes as it is first applied, like some shiny, twinkling nebula. It is a bracing introduction to a perfume which is very Comme des Garcons: unruly, bold and commanding. Violets feature heavily in the opening of this scent, but it is not a mainstream interpretation of violets: they are cold and metallic, as if plucked from the gardens of a dark moon found in some distant starscape. CdG list meteorite and magma as starring accords, and one would agree that they have succeeded in introducing a cold mineralic quality to the composition. The scent does however, retain some earthbound accords as well - a dewy rose, peppery carnation and slightly muddy vetiver feature, though, I get the impression that they too may have been cryogenically frozen and then defrosted again in some intergalactic ark. There is a distinct sensation of breathing refrigerated air here which is not at all unpleasant... just interesting. If Stephen Jones and Comme des Garcons set out to compel ...
Sciatica Should I Go To Hospital? Im trying to keep a stiff (but not frozen) upper lip, I dont want to become known as the guy who put the cry in cryotherapy. Here we go, says Amanda, the cryo tank operator, cheerfully. Gleefully? Three minutes! I wonder if thats what they said to Ted Williams, whose head is cryogenically frozen in a tank in Arizona. What if my family learned I have a terminal disease, but they dont want to tell me, and this is their way of tricking me into being frozen until a cure is found? They say the Kentucky Derby is the most exciting two minutes in sports.. ... Continue reading ...
The Broad-Band X-Ray Telescope (BBXRT) was designed to carry out moderate resolution spectrophotometry of cosmic X-ray sources in the 0.3-12 keV band from the Space Shuttle. It consists of a pair of coaligned conical foil telescopes, with cryogenically cooled Si(Li) spectrometers as focal instruments. It was flown as part of the Astro-1 mission in December, 1990. The in-flight performance of the instrument was essentially as predicted on the basis of ground calibration and modelling. We discuss the performance of the system, with emphasis on the conical mirror systems, and present some preliminary scientific results which illustrate the power of broad band, high sensitivity X-ray spectrophotometry ...
A method and apparatus for transmural ablation using an instrument containing two electrodes or cryogenic probes. A clamping force is exerted on the two electrodes or probes such that the tissue of the hollow organ is clamped therebetween. Bipolar RF energy is then applied between the two electrodes, or the probes are cryogenically cooled, thus ablating the tissue therebetween. A monitoring device measures a suitable parameter, such as impedance or temperature, and indicates when the tissue between the electrodes has been fully ablated.
At the Alcor Life Extension Foundation, 67 bodies—mostly just severed heads—lay cryogenically preserved in liquid nitrogen, waiting for the day when science can reanimate them.
A series of density functional theory (DFT) and quantum mechanics/molecular mechanics (QM/MM) calculations are used to investigate the binding of platinum and ruthenium anticancer drugs to DNA. The qualitative and quantitative features of Beckes half-and-half (BHandH) functional for calculating geometries, binding energies and harmonic frequencies of non- covalently bound systems are tested and the intermolecular interactions are characterised and quantified using the QTAIM electron densities. Application of this DFT-QTAIM approach to complexes of the type (n6-arene)Ru(en)(nucleobase) 2+ shows a clear preference for binding at guanine over any other base both in gas phase and in aqueous solution, a trend explained on the basis of QTAIM and molecular orbital data. Key parameters of the QM/MM methodology within the ONIOM scheme and efficient geometry optimisation strategies are examined for applications involving DNA oligonucleotides. Calculations on cis- Pt(NH3)2 2+ (cisplatin) bound to ...
Hyperlipidemia is characterized by abnormal or elevated lipids and/or lipoproteins levels in the blood. Elevated lipids levels have been observed in autoimmune diseases, such as lupus, rheumatoid arthritis and psoriasis, leading to a significant increase in cardiovascular disease-related morbidity and mortality. There is growing evidence that certain Toll like receptors (TLR) are involved in inflammation processes that contribute to alteration of lipid levels. Our studies have shown that treatment with a dual antagonist of TLR7 and TLR9 (antagonist) lowers total cholesterol (TC), LDL-cholesterol (LDL-c), Triglycerides and Leptin in a dose dependent manner in C57BL/6 and ApoE−/− mice fed with high fat diet (HFD). Lowering of serum levels of TC was inversely correlated with levels of IL−10. Antagonist treatment was associated with inhibition of plaque formation and improvement of liver and kidney steatosis. Further studies have demonstrated lowering of TC with concomitant induction of IL-10 ...
Pill with imprint BCM 50 is White, Round and has been identified as Bicalutamide 50 mg. It is supplied by Synthon Pharmaceuticals, Inc..
Experimental. General. All chemicals were purchased from Sigma Aldrich, except [Rh(Cp*)Cl2]2 and [Ir(Cp*)Cl2]2 which were obtained from Strem. All chemicals were used as received. N-(7-chloroquinolin-4-yl)ethane-1,2-diamine [31] and pyrazine-2-car-bonyl chloride [32] were synthesized according to literature procedures. 1H NMR spectra were recorded on a Varian Inova 500 MHz spectrometer at ambient temperature using the residual solvent peak as internal standard. High resolution mass spectra (HRMS) were obtained on an LTQ Velos Orbitrap mass spectrometer in ESI positive mode and a resolution (Rs) of 30 000; raffinose and sodium was added for lockmass correction.. Syntheses. N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide, L. N-(7-chloroquinolin-4-yl)ethane-1, 2-diamine (559 mg, 2.53 mmol) was suspended in a dichloromethane (200 ml) solution of triethylamine (0.529 ml, 3.8 mmol) and the suspension was added to an ice cold solution of freshly sublimated pyrazine-2-carbonyl chloride ...
GABA (Gamma-aminobutyric acid) was the first new transmitter to be discovered after the three classic transmitters (norepinephrine, acetylcholine, and serotonin). It is one of the most frequently occurring transmitters in the central nervous system. Generally it has an inhibitory function. Sedative-hypnotic drugs like barbiturates act by stimulating release of GABA-like substances.. What is the usual effect of GABA?. Valium and the class of tranquilizers it represents, benzodiazepines, also act on the GABA-related transmitter systems. The benzodiazepines and the barbiturates are quite different in their structure, clinical effects, and mode of action...but they both act to reduce anxiety, and they both do it by boosting levels of GABA.. Prev page , Back to top , T of C , Next page. ...
Localized cryotherapy is the application of cryogenically cooled air, using a controlled beam of vaporized liquid nitrogen to a specific area of the body. This treatment is designed to decrease inflammation and swelling in the targeted area. It is perfect for any strain, sprain, ache or injury and allows for faster recovery. With such an intense cooling effect, the local area treatment only needs to be conducted for 5-10 minutes.. ...
Artificial Intelligence: A.I. - It is a time when natural resources are limited and technology is advancing at an astronomical pace. Where you live is monitored, what you eat is engineered, and the person serving you is not a person at all. Its artificial. Gardening, housekeeping, companionship -- there is a robot for every need. Except love. Emotion is the last, controversial frontier in robot evolution. Robots are seen as sophisticated appliances; theyre not supposed to have feelings. But with so many parents not yet approved to have children, the possibilities abound. Cybertronics Manufacturing has created the solution. His name is David (Osment). A robotic boy, the first programmed to love, David is adopted as a test case by Cybertronics employee Henry Swinton (Sam Robards) and his wife Monica (Frances OConnor), whose own terminally ill child has been cryogenically frozen until a cure can be found. But the very day David is programmed to love the grieving mother, her own son comes out of his coma
Since implementing the rapid-tooling process, the company has doubled its revenues while gaining speed and efficiency advantages using direct metal laser-sintering with cryogenic processing compared with conventional CNC milling of aluminum molds. CPM Fastools process uses EOS DMLS technology to produce fully dense metal-core and cavity inserts. The inserts, and all mold components, are cryogenically processed to relieve residual stress and increase wear resistance. The company says its production molds are ideal for resins that are difficult to injection-mold and cause rapid tooling wear. We have made production tools for molding tough resins like polyphenylsulfone and glass-filled engineering plastics, adds Moore.. More traditional prototyping processes using plastics for rapid prototyping purposes include FDM, stereolithography, and 3-D printing, methods which continue to account for the majority of prototypes built for industry. Stratasys, which according to the Wohlers Report shipped 34% ...
This disk contains 2 videos that accompanies the talk. Twenty years ago, the Lunar Prospector remote sensing satellite provided evidence of relatively large hydrogen concentrations at the lunar poles and in particular concentrated in permanently shadowed craters. The scientific hypothesis is that the hydrogen is in the form of cryo-trapped water just under the surface of the soil. If true this would mean that an average of about 2% water ice is mixed with the lunar soil existing in the form of ice at cryogenic temperatures. For 5 years we have been investigating the use of microwaves for the processing of lunar soil. One of the early uses could be to use microwave energy to extract volatiles and in particular water from the lunar permafrost. Prototype experiments have shown that microwave energy at 2.45 GHz, as in consumer microwave ovens, will couple with and heat cryogenically cooled lunar soil permafrost simulant, resulting in the rapid sublimation of water vapor into the vacuum chamber. The ...
The geometrical and electronic structures of Ln[(H2O)9]3+ and [Ln(BTP)3]3+, where Ln = Ce-Lu, have been evaluated at the density functional level of theory using three related exchange-correlation (xc-)functionals. The BHLYP xc-functional was found to be most accurate, and this, along with the B3LYP functional, was used as the basis for topological studies of the electron density via the quantum theory of atoms in molecules (QTAIM). This analysis revealed that, for both sets of complexes, bonding was almost identical across the Ln series and was dominated by ionic interactions. Geometrical and electronic structures of actinide (An = Am, Cm) analogues were evaluated, and [An(H2O)9]3+ + [Ln(BTP)3]3+ → [Ln(H2O)9]3+ + [An(BTP)3]3+ exchange reaction energies were evaluated, revealing Eu ↔ Am and Gd ↔ Cm reactions to favor the An species. Detailed QTAIM analysis of Eu, Gd, Am, and Cm complexes revealed increased covalent character in M-O and M-N bonds when M = An, with this increase being more ...
Hydroxychloroquine N-Oxide ; ANT-HCLQ-01 ; 1449223-88-4 ; 4-((7-chloroquinolin-4-yl)amino)-N-ethyl-N-(2-hydroxyethyl)pentan-1-amine oxide ; Supplier of Hydroxychloroquine Impurities ; Hydroxychloroquine Impurity ; Hydroxychloroquine Impurities
The self-assembly of star-shaped 1,3,5-tris(3,5-dibromophenyl)benzene molecules on Au(111)-() in a vacuum is investigated using scanning tunneling microscopy and core-level spectroscopy. Scanning tunneling microscopy shows that the molecules self-assemble into a hexagonal porous halogen-bonded nanoarchitecture. Thi
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... chloroquinolinols MeSH D03.438.810.350.625.250.260 - chlorquinaldol MeSH D03.438.810.350.625.400 - clioquinol MeSH D03.438. ...
... chloroquinolinols MeSH D03.438.810.350.625.250.260 - chlorquinaldol MeSH D03.438.810.350.625.400 - clioquinol MeSH D03.438. ...
Chloroquinolinols D3.438.810.350.625.250 D3.633.100.810.350.625.250 Chlorothiazide D3.438.174.261 D3.633.100.174.261 ...
Animals , Male , Swine/growth & development , Chloroquinolinols/administration & dosage , Colistin/administration & dosage , ... Chloroquinolinols/adverse effects , Colistin/adverse effects , Dietary Supplements/adverse effects , Diarrhea/chemically ...
DipeptidasesArachidonate 5-LipoxygenaseLipoxygenase InhibitorsQuinolinesDicarboxylic AcidsAutacoidsLipoxinsChloroquinolinols ...

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