Chlorogenic Acid
Caffeic Acids
Rutin
Coumaric Acids
Coffea
Hydroxybenzoates
Cynara scolymus
Coffee
Ilex paraguariensis
Plant Extracts
Crataegus
Catechol Oxidase
Scopolia
Achillea
Free Radical Scavengers
Antioxidants
Ileostomy
Acanthopanax
Drugs, Chinese Herbal
Iridoid Glucosides
Echinacea
Protein Tyrosine Phosphatases
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Protein Tyrosine Phosphatase, Non-Receptor Type 1
A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.
Cellular Phone
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Powders
Metabolome
Metabolomics
Intestine, Small
Protein Binding
Solubility
Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids. (1/190)
Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a double-stranded DNA copy of the RNA genome into the host cell chromosome for productive infection. The viral enzyme, integrase, catalyzes the integration of retroviral DNA and represents an attractive target for developing antiretroviral agents. We identified several derivatives of dicaffeoylquinic acids (DCQAs) that inhibit HIV-1 replication in tissue culture and catalytic activities of HIV-1 integrase in vitro. The specific step at which DCQAs inhibit the integration in vitro and the mechanism of inhibition were examined in the present study. Titration experiments with different concentrations of HIV-1 integrase or DNA substrate found that the effect of DCQAs was exerted on the enzyme and not the DNA. In addition to HIV-1, DCQAs also inhibited the in vitro activities of MLV integrase and truncated variants of feline immunodeficiency virus integrase, suggesting that these compounds interacted with the central core domain of integrase. The inhibition on retroviral integrases was relatively specific, and DCQAs had no effect on several other DNA-modifying enzymes and phosphoryltransferases. Kinetic analysis and dialysis experiments showed that the inhibition of integrase by DCQAs was irreversible. The inhibition did not require the presence of a divalent cation and was unaffected by preassembling integrase onto viral DNA. The results suggest that the irreversible inhibition by DCQAs on integrase is directed toward conserved amino acid residues in the central core domain during catalysis. (+info)Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling. (2/190)
The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key regulatory factor of blood glucose homoeostasis. To identify the glucose 6-phosphate transporter T1, we have performed photoaffinity labelling of human and rat liver microsomes by using the specific photoreactive glucose-6-phosphate translocase inhibitors S 0957 and S 1743. Membrane proteins of molecular mass 70, 55, 33 and 31 kDa were labelled in human microsomes by [3H]S 0957, whereas in rat liver microsomes bands at 95, 70, 57, 54, 50, 41, 33 and 31 kDa were detectable. The photoprobe [3H]S 1743 led to the predominant labelling of a 57 kDa and a 50 kDa protein in the rat. Stripping of microsomes with 0.3% CHAPS retains the specific binding of T1 inhibitors; photoaffinity labelling of such CHAPS-treated microsomes resulted in the labelling of membrane proteins of molecular mass 55, 33 and 31 kDa in human liver and 50, 33 and 31 kDa in rat liver. Photoaffinity labelling of human liver tissue samples from a healthy individual and from liver samples of patients with a diagnosed glycogen-storage disease type 1b (GSD type 1b; von Gierke's disease) revealed the absence of the 55 kDa protein from one of the patients with GSD type 1. These findings support the identity of the glucose 6-phosphate transporter T1, with endoplasmic reticulum protein of molecular mass 50 kDa in rat liver and 55 kDa in human liver. (+info)Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine. (3/190)
Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, from I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 microM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa. (+info)The small intestine can both absorb and glucuronidate luminal flavonoids. (4/190)
We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum. (+info)Expression of tryptophan decarboxylase and tyrosine decarboxylase genes in tobacco results in altered biochemical and physiological phenotypes. (5/190)
The substrate specificity of tryptophan (Trp) decarboxylase (TDC) for Trp and tyrosine (Tyr) decarboxylase (TYDC) for Tyr was used to modify the in vivo pools of these amino acids in transgenic tobacco. Expression of TDC and TYDC was shown to deplete the levels of Trp and Tyr, respectively, during seedling development. The creation of artificial metabolic sinks for Trp and Tyr also drastically affected the levels of phenylalanine, as well as those of the non-aromatic amino acids methionine, valine, and leucine. Transgenic seedlings also displayed a root-curling phenotype that directly correlated with the depletion of the Trp pool. Non-transformed control seedlings could be induced to display this phenotype after treatment with inhibitors of auxin translocation such as 2,3,5-triiodobenzoic acid or N-1-naphthylphthalamic acid. The depletion of aromatic amino acids was also correlated with increases in the activities of the shikimate and phenylpropanoid pathways in older, light-treated transgenic seedlings expressing TDC, TYDC, or both. These results provide in vivo confirmation that aromatic amino acids exert regulatory feedback control over carbon flux through the shikimate pathway, as well as affecting pathways outside of aromatic amino acid biosynthesis. (+info)Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. (6/190)
Commercially available St. John's wort (Hypericum perforatum) extracts, preparations that are used in the treatment of depression, were examined for the potential to inhibit human cytochrome P450 (CYP) enzyme activities, specifically CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Crude extracts demonstrated inhibition of each of these five enzymes, with CYP2D6, CYP2C9, and CYP3A4 being more sensitive than CYP1A2 and CYP2C19. Extracts were fractionated by HPLC, and each of the fractions was tested for inhibition of these five CYPs to identify individual constituents with inhibitory activity. Several fractions were shown to possess inhibitory activity, including the fractions containing hyperforin (the putative active antidepressant constituent), I3,II8-biapigenin, and hypericin. Hyperforin and I3,II8-biapigenin were isolated from the extract, and inhibition constants for the five CYP activities were measured. In addition, three other constituents, hypericin, quercetin, and chlorogenic acid, were tested for inhibitory activity toward the CYP enzymes. The flavonoid compound I3,II8-biapigenin was shown to be a potent, competitive inhibitor of CYP3A4, CYP2C9, and CYP1A2 activities with K(i) values of 0.038, 0.32, and 0.95 microM, respectively. Hyperforin was a potent noncompetitive inhibitor of CYP2D6 activity (K(i) = 1.5 microM) and competitive inhibitor of CYP2C9 and CYP3A4 activities (K(i) = 1.8 and 0.48 microM, respectively). Hypericin also demonstrated potent inhibition of several CYP activities. These in vitro data indicate that St. John's wort preparations contain constituents that can potently inhibit the activities of major human drug-metabolizing enzymes and suggest that these preparations should be examined for potential pharmacokinetic drug interactions in vivo. (+info)Inhibition of NFkappaB by methyl chlorogenate from Eriobotrya japonica. (7/190)
Methylchlorogenic acid (MC) is one of the main components in the leaves of Eriobotrya japonica. We previously reported that MC is the most potent antioxidant among several components of Eriobotrya japonica, and its antioxidant activity is stronger than that of chlorogenic acid. Antioxidants are expected to inhibit redox-sensitive NFkappaB activation since NFkappaB is readily influenced by cellular oxidative state. Based on these findings, in vivo experiments with MC were conducted to determine its ability to downregulate the NFkappaB activation in mouse liver. Results clearly showed that MC is a potent suppressor of BHP-induced NFkappaB activation. We observed a significant reduction by MC on BHP-induced translocation of p65 subunit of NFkappaB. This may be due to formation of p50/p65 heterodimer, which is mainly inducible NFkappaB. MC slightly blocked the BHP-induced IkappaB alpha degradation. There is a possibility of IkappaB alpha resynthesis via activated NFkappaB during a 5 h waiting period following BHP injection. The present results suggest that MC may inhibit NFkappaB activation, exhibiting its ability to downregulate the NFkappaB-dependent gene expression. Thus, it can be expected that MC may have potential for therapeutic intervention on various NFkappaB-dependent pathological conditions such as inflammatory or possibly mutagenic processes. (+info)Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation. (8/190)
Reactive oxygen species (ROS) are known to modulate activities of a host of kinases, phosphatases and transcription factors. Rutin and chlorogenic acid (CGA) are the major polyphenolic antioxidants present in the small molecular fraction of smokeless tobacco leaf extracts, as ascertained by reverse-phase high-pressure liquid chromatography (HPLC) and mass spectrometry. Levels of intracellular ROS in resting versus antigen-immunoglobulin E (IgE)-challenged murine mast cells were measured at 510 nm by fluorescence-activated cell sorting (FACS) using carboxy-dichlorofluorescein (DCFH-DA). Enhanced ROS production was observed in IgE-sensitized mast cells following antigenic challenge. Rutin and CGA reduced ROS levels in antigen-IgE-activated mast cells. Concomitantly, they also profoundly inhibited histamine release by these activated mast cells. In contrast, rutin and CGA augmented the inducible cytokine messages, i.e. interleukin (IL)-10, IL-13, interferon-gamma (IFN-gamma), IL-6 and tumour necrosis factor-alpha (TNF-alpha) in IgE-sensitized mast cells following antigen challenge. This study indicates that tobacco polyphenolic antioxidants that quench intracellular ROS, differentially affect two effector functions of antigen-IgE-activated mast cells. This model system may be employed to determine the molecular target of polyphenols. The potential role of these polyphenolic antioxidants on IgE-mediated allergy in vivo depends on a balance of their differential effects on mast cell activation. (+info)
Human Metabolome Database: Showing metabocard for Chlorogenic acid (HMDB0003164)
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Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats.
PRIME PubMed | Absorption of chlorogenic acid and caffeic acid in rats after oral administration
Effects of non-covalent interactions with 5-O-caffeoylquinic acid (chlorogenic a :: TNO Repository
The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures
Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPKα-LXRα/SREBP-1c pathway in high-fat diet...
The isolation and mapping of a novel hydroxycinnamoyltransferase in the globe artichoke chlorogenic acid pathway | BMC Plant...
Eggplant benefits - NatureWord
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Myelodysplastic syndrome
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Chlorogenic Acid in Coffee is powerful Immune modulator - Prof. Marshalls Perspective - PROF. MARSHALLS PERSPECTIVE - The...
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Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. - PubMed - NCBI
Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned...
Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic...
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Investigating the synergistic antioxidant effects of some flavonoid and phenolic compounds
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Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species<...
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Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis |...
Dose-response plasma appearance of coffee chlorogenic and phenolic acids in adults - Renouf - 2013 - Molecular Nutrition & Food...
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Determination of Chlorogenic Acid of Different Organs from Taraxacum mongolicum by High Performance Liquid Chromatography--...
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Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice. | Sigma-Aldrich
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Coffee bean
Nonvolatile chlorogenic acids[edit]. Chlorogenic acids belong to a group of compounds known as phenolic acids, which are ... Chlorogenic acids are homologous compounds comprising caffeic acid, ferulic acid and 3,4-dimethoxycinnamic acid, which are ... The lipids found in green coffee include: linoleic acid, palmitic acid, oleic acid, stearic acid, arachidic acid, diterpenes, ... hexanoic acid (fatty-rancid odor), heptanoic acid (fatty odor), octanoic acid (repulsive oily rancid odor); nonanoic acid (mild ...
Cynarine
... it is an ester formed from quinic acid and two units of caffeic acid. Chlorogenic acid Panizzi, Luigi; Scarpati, Maria Luisa ( ... Cynarine is a hydroxycinnamic acid derivative and a biologically active chemical constituent of artichoke (Cynara cardunculus ...
Hypericum perforatum
Phenolic acids (e.g. chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, p-hydroxybenzoic acid, vanillic acid) ... Saturated fatty acids (e.g. isovaleric acid (3-methylbutanoic acid), myristic acid, palmitic acid, stearic acid) Alkanols (e.g ... Naphthodianthrone, flavonoid, amentoflavone, and pseudohypericin levels are reduced; chlorogenic acid levels increased. ... Myricetin Quercetin Quercitrin Isoquercitrin Luteolin Catechin Epicatechin Epigallocatechin Chlorogenic acid Caffeic acid ...
RNA interference
PPO-silenced apples are unable to convert chlorogenic acid into the standard quinone product. There are several opportunities ... Niggeweg R, Michael AJ, Martin C (June 2004). "Engineering plants with increased levels of the antioxidant chlorogenic acid". ... Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. PMC 5056990. PMID 27673562. Naito Y, Yamada T, Matsumiya T, Ui-Tei K, ... Qiu S, Adema CM, Lane T (2005). "A computational study of off-target effects of RNA interference". Nucleic Acids Research. 33 ( ...
Maranta leuconeura
Occurrence of rosmarinic acid, chlorogenic acid and rutin in Marantaceae species. Yana Abdullah, Bernd Schneider and Maike ... Rosmarinic acid can be found in plants in the family Marantaceae such as Maranta leuconeura. Maranta usually experiences ...
Coffee production
"Green coffee infusion as a source of caffeine and chlorogenic acid". Journal of Food Composition and Analysis. 84: 103307. doi: ... Red berries, with their higher aromatic oil and lower organic acid content, are more fragrant, smooth, and mellow. As such, ...
Coffee
"Green coffee infusion as a source of caffeine and chlorogenic acid". Journal of Food Composition and Analysis. 84: 103307. doi: ... During roasting, aromatic oils and acids weaken, changing the flavor; at 205 °C (401 °F), other oils start to develop. One of ... Lighter roasts have a more complex and therefore perceived stronger flavor from aromatic oils and acids otherwise destroyed by ... They are especially appreciated by worms and acid-loving plants such as blueberries. Some commercial coffee shops run ...
Marantaceae
Abdullah, Yana (2008). "Occurrence of rosmarinic acid, chlorogenic acid and rutin in Marantaceae species". Phytochemistry ... Rosmarinic acid can be found in plants in the family Marantaceae such as species in the genera Maranta (Maranta leuconeura, ...
Green coffee extract
It included studies of chlorogenic acids both as a constituent of coffee and directly as a purified extract, and suggested ... A larger 2017 review assessed the effects of chlorogenic acids, the main phenolic compounds in green coffee extract. ... "Green coffee infusion as a source of caffeine and chlorogenic acid". Journal of Food Composition and Analysis. 84: 103307. doi: ... "The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the ...
Chlorogenate hydrolase
... and chlorogenic acid esterase. Schobel B, Pollmann W (1980). "Isolation and characterization of a chlorogenic acid esterase ... Schobel B, Pollmann W (1980). "[Further characterization of a chlorogenic acid hydrolase from Aspergillus niger (author's ...
Yacón
The major antioxidative compounds in yacon are chlorogenic acid and L-tryptophan. Yacon contains also different phenolic ... In addition, yacon juice is rich in free essential amino acids. Dry basis ND Not determined Carbohydrate was estimated by the ... Kapuler, A.M; Gurusiddiah, Sarangamat (1993-10-14). "The Twenty Protein Amino Acids Free in the Juices of Our Common Vegetables ... Kapuler, A. M.; Gurusiddiah, Sarangamat (1993-10-14). "The Twenty Protein Amino Acids Free in the Juices of Our Common ...
Nicotiana tabacum
The main polyphenols contained in the tobacco leaf are rutin and chlorogenic acid. Amino acids contained include glutamic acids ... Roberts, E.A.H. (1951). "The polyphenols and amino acids of tobacco leaf". Archives of Biochemistry and Biophysics. 33 (2): 299 ... propionic acid, anthalin, anethole, acrolein, cembrene, choline, nicotelline, nicotianine, and pyrene. The regions that have ... asparagine, glutamine, and γ-Aminobutyric acid Pyridine alkaloids are present in tobacco as free bases and salts. Nicotine ...
Thiamine
Some examples of these antagonists are caffeic acid, chlorogenic acid, and tannic acid. These compounds interact with the ... Thiamine and its acid metabolites (2-methyl-4-amino-5-pyrimidine carboxylic acid, 4-methyl-thiazole-5-acetic acid, and thiamine ... PDH links glycolysis to the citric acid cycle, while the reaction catalyzed by OGDH is a rate-limiting step in the citric acid ... In particular in E. coli, it seems to play a role in response to amino acid starvation. Adenosine thiamine triphosphate (AThTP ...
Phyllostachys edulis
Hydroxycinnamic acids p-coumaric acid caffeic acid ferulic acid Chlorogenic acids chlorogenic acid (3-(3,4-dihydroxycinnamoyl) ... quinic acid) 3-O-(3'-methylcaffeoyl)quinic acid 5-O-caffeoyl-4-methylquinic acid 3-O-caffeoyl-1-methylquinic acid (C17H20O9, ... Identification and Antioxidant Activity of Novel Chlorogenic Acid Derivatives from Bamboo (Phyllostachys edulis). Mee-Hyang ... Journal of Food Biochemistry Phyllostachys edulis Compounds Inhibit Palmitic Acid-Induced Monocyte Chemoattractant Protein 1 ( ...
Chlorogenate-glucarate O-hydroxycinnamoyltransferase
"Enzymic Synthesis of Caffeoylglucaric Acid from Chlorogenic Acid and Glucaric Acid by a Protein Preparation from Tomato ... Strack D, Gross W (1990). "Properties and Activity Changes of Chlorogenic Acid:Glucaric Acid Caffeoyltransferase From Tomato ( ... Other names in common use include chlorogenate:glucarate caffeoyltransferase, chlorogenic acid:glucaric acid O- ...
Lonicera japonica
Other phenolic compounds present in the plant are hyperoside, chlorogenic acid, and caffeic acid. The two secoiridoid ... protocatechuic acid, methyl chlorogenic acid, and luteolin. The two biflavonoids, 3′-O-methyl loniflavone and loniflavone, ... Peng, Youyuan; Liu, Fanghua; Ye, Jiannong (2005). "Determination of Phenolic Acids and Flavones in Lonicera japonica Thumb. By ... Lonicera japonica contains methyl caffeate, 3,4-di-O-caffeoylquinic acid, methyl 3,4-di-O-caffeoylquinate, ...
Altered Schaedler flora
For example, hippurate and chlorogenic acid metabolite level in mice change due to microflora. The synthesis pathway depends on ...
Eryngium planum
... chlorogenic, and caffeic acids in the basal leaves and the roots of intact plants, and greater concentrations in E. planum from ... chlorogenic and caffeic acids in in vitro cultures of Eryngium planum L.". Acta Physiol Plant. 34: 2425-2433. Media related to ... The groups of bioactive compounds present in E. planum are phenolic acids, triterpenoid saponins, flavonoids, coumarins, and ... Qualitative and quantitative determinations of the phenolic acids by reverse phase high-performance liquid chromatography (RP ...
Prune
... mainly as neochlorogenic acids and chlorogenic acids) and sorbitol. Prunes are used in preparing both sweet and savory dishes. ...
Tobacco smoke
Tobacco polyphenols (e. g., caffeic acid, chlorogenic acid, scopoletin, rutin) determine the taste and quality of the smoke. ...
Quinate O-hydroxycinnamoyltransferase
"Enzymic Synthesis of Caffeoylglucaric Acid from Chlorogenic Acid and Glucaric Acid by a Protein Preparation from Tomato ... "Enzymatic-synthesis of hydroxycinnamic acid-esters of sugar acids and hydroaromatic acids by protein preparations from rye ( ...
Heptacodium
The leaf blades of Heptacodium have been found to contain flavonoids, tannins, alkaloids, saponins, lignin and chlorogenic acid ...
Prune juice
... mainly as neochlorogenic acids and chlorogenic acids) and sorbitol. Prune juice is often produced using hot extraction methods ...
Eryngium foetidum
Caffeic acid, chlorogenic acid (CGA), and kaempferol have been among the phenolic compounds found in E. foetidum leaves. Cuban ...
Mouse model of colorectal and intestinal cancer
... the colonic tissues of chlorogenic acid-fed mice showed amelioration of the molecular aberrancies, suggesting that chlorogenic ... However, in mice fed diet plus DOC plus the antioxidant chlorogenic acid, the frequency of colon cancer was reduced. ... Humans with high levels of the diet-related bile acid deoxycholate (DOC) in their colons are at a substantially increased risk ... a secondary bile acid". Arch. Toxicol. 85 (8): 863-71. doi:10.1007/s00204-011-0648-7. PMC 3149672. PMID 21267546. Prasad AR, ...
Glucose-6-phosphate translocase
... and chlorogenic acid. Other natural product inhibitors of G6PT1 are found in the fungi Chaetomium carinthiacum, Bauhinia ... such as mercaptopicolinic acid and diazobenzene sulfonate have some degree of inhibiting potential for G6PT1 but systematically ...
List of coffee drinks
... and Grind Size on Caffeine and Chlorogenic Acid Concentrations in Cold Brew Coffee". Scientific Reports. 7 (1): 17979. Bibcode: ... Amerine, M. A.; Roessler, E. B.; Ough, C. S. (1 January 1965). "Acids and the Acid Taste. I. The Effect of pH and Titratable ... Coffee beans contain a number of parts that are more soluble at higher temperatures, such as caffeine, oils and fatty acids. ... The pH of cold and hot brew coffee is similar but cold brew coffee has a lower titratable acid concentration. Both pH and ...
Thalia geniculata
Biota of North America Program, map, Thalia geniculata Occurrence of rosmarinic acid, chlorogenic acid and rutin in Marantaceae ... Rosmarinic acid can be found in plants in the family Marantaceae such as Thalia geniculata. List of leaf vegetables Ghogue, J.- ...
RNA interference
Niggeweg R, Michael AJ, Martin C (June 2004). "Engineering plants with increased levels of the antioxidant chlorogenic acid". ... PPO-silenced apples are unable to convert chlorogenic acid into the standard quinone product.[2] ... "Nucleic Acids Research. 33 (Web Server issue): W589-91. doi:10.1093/nar/gki419. PMC 1160180. PMID 15980542.. ... "Nucleic Acids Research. 32 (Web Server issue): W113-20. doi:10.1093/nar/gkh408. PMC 441546. PMID 15215362.. ...
Interferencia de ARN, a enciclopedia libre
Niggeweg R, Michael A, Martin C (2004). "Engineering plants with increased levels of the antioxidant chlorogenic acid". Nat ... "Nucleic Acids Res 33 (Web Server issue): W589-91. PMC 1160180. PMID 15980542. doi:10.1093/nar/gki419.. ... "Nucleic Acids Res 32 (Web Server issue): W113-20. PMC 441546. PMID 15215362. doi:10.1093/nar/gkh408.. ... "Nucleic Acids Res 32 (Web Server issue): W124-9. PMC 441580. PMID 15215364. doi:10.1093/nar/gkh442.. ...
Pentamidine
Some cases of anemia, possibly related to folic acid deficiency, have been described.[18] ...
Thiamine
Some examples of these antagonists are caffeic acid, chlorogenic acid, and tannic acid. These compounds interact with the ... Thiamine and its acid metabolites (2-methyl-4-amino-5-pyrimidine carboxylic acid, 4-methyl-thiazole-5-acetic acid, and thiamine ... PDH links glycolysis to the citric acid cycle, while the reaction catalyzed by OGDH is a rate-limiting step in the citric acid ... "Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and ...
Roselle (plant)
The major identified compounds include neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeoylshikimic acid and ... Pau, L. T.; Salmah, Y.; Suhaila, M. (2002). "Antioxidative properties of roselle (Hibiscus sabdariffa L.) in linoleic acid ... as well as protocatechuic acid. The dried calyces contain the flavonoids gossypetin, hibiscetine and sabdaretine. The major ...
Asteraceae
They produce iso/chlorogenic acid, sesquiterpene lactones, pentacyclic triterpene alcohols, various alkaloids, acetylenes ( ...
Prune
... mainly as neochlorogenic acids and chlorogenic acids) and sorbitol.[4] ...
NONOate
Most NONOates are stable in alkaline solution above pH 8.0 (e. g. 10 mM NaOH) and can be stored at −20 °C in this way for the short term. To generate NO from NONOates, the pH is lowered accordingly. Typically, a dilution of the stock NONOate solution is made in a phosphate buffer (pH 7.4; tris buffers can also be used) and incubated at room temperature for the desired time to allow NO to accumulate in solution. This is often visible as bubbles at high NONOate concentrations. Incubation time is important, since the different NONOates have different half-lives (t½) in phosphate buffer at pH 7.4. For example, the half-life of MAHMA NONOate under these conditions is ~3.5 minutes, whilst the t½ of DPTA NONOate is 300 minutes. This is often useful in biological systems, where a combination of different NONOates can be used to give a sustained release of nitric oxide. At pH 5.0, most NONOates are considered to decompose almost instantaneously. ...
Alkyl nitrites
... are also used in the formation of oximes with the stronger carbon acids and acid or base catalysis for example ... Organic nitrites are prepared from alcohols and sodium nitrite in sulfuric acid solution. They decompose slowly on standing, ... Formally they are alkyl esters of nitrous acid. They are distinct from nitro compounds (R-NO2). ... in the reaction of 2-butanone, ethyl nitrite and hydrochloric acid forming the oxime,[7] the similar reaction with phenacyl ...
Deoxycholic acid
Caffeic acid is also a digestive break-down product of chlorogenic acid, high in coffee and some fruits and vegetables.[37] ... Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into ... There are additional secondary bile acids, such as ursodeoxycholic acid. Deoxycholic acid is soluble in alcohol and acetic acid ... 12α-dihydroxy-5β-cholan-24-oic acid, is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic ...
Pineapple
... syringic acid, vanillin, ferulic acid, sinapic acid, coumaric acid, chlorogenic acid, epicatechin, and arbutin.[49][50] ... The pineapple carries out CAM photosynthesis,[13] fixing carbon dioxide at night and storing it as the acid malate, then ... "Smooth cayenne", a 2.5- to 3.0-kg (5- to 6-lb), pale yellow- to yellow-fleshed, cylindrical fruit with high sugar and acid ... Pineapple fruits and peels contain diverse phytochemicals, among which are polyphenols, including gallic acid, ...
ഹൈപെരികം പെർഫൊറാറ്റം - വിക്കിപീഡിയ
Amino acids • Bodybuilding supplement • Energy drink • Energy bar • Fatty acids • Herbal Supplements • Minerals • Prebiotics • ... Folic acid (B9) • Cyanocobalamin (B12) • Ascorbic acid (ജീവകം സി) • Ergocalciferol and Cholecalciferol (ജീവകം ഡി) • Tocopherol ... Retinol (ജീവകം എ) • B vitamins: തയാമിൻ (B1) • Riboflavin (B2) • Niacin (B3) • Pantothenic acid (B5) • Pyridoxine (B6) • Biotin ... Lipoic acid • Milk thistle • Melatonin • Red yeast rice • Royal jelly • Saw palmetto • സ്പൈറുലിന • St John's wort • Taurine • ...
Philadelphia chromosome
Bandyopadhyay, G (2004). "Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase- ...
Phytosteroid
α-Cyano-4-hydroxycinnamic acid. *Caffeic acid. *Chicoric acid. *Cinnamic acid. *Chlorogenic acid ... Dihydroxybenzoic acids. *2,3-Dihydroxybenzoic acid (Hypogallic acid). *2,4-Dihydroxybenzoic acid ...
7-Nitroindazole
... , or 7-NI, is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. Nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).[1] Nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowing cell signalling, so nitroindazole indirectly inhibits this signalling process.[2][3][4] Other inhibitors exist such as 3-bromo-7-nitroindazole, which is more potent but less specific,[5] or NPA (N-propyl-L-arginine), which acts on a different site.[6] ...
تریپتوفان - ویکیپدیا، دانشنامهٔ آزاد
Lysergic acid 2-butyl amide • Lysergic acid 3-pentyl amide • Methysergide; Phenethylamines: 25I-NBF • 25I-NBMD • 25I-NBOH • 25I ... Agonists: Lysergamides: ALD-52 • Ergometrine • Lisuride • Lysergic acid 2,4-dimethylazetidide • الاسدی • LSD-Pip • ... Tryptophan or (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid ... Cichoric acid. *سینامیک اسید. *Chlorogenic acid. *Diferulic ...
Moringa (geed)
"Chlorogenic acid" kan hore wuxuu hoos u dhigaa dhiig karka, kan dambane wuxuu hoos u dhigaa sokorta khaasatan markii wax la ...
Common fig
... such as gallic acid, chlorogenic acid, syringic acid, (+)-catechin, (−)-epicatechin and rutin.[37][38] Fig color may vary ... Veberic R, Colaric M, Stampar F (2008). "Phenolic acids and flavonoids of fig fruit (Ficus carica L.) in the northern ...
Dietary fiber
α-Cyano-4-hydroxycinnamic acid. *Caffeic acid. *Cichoric acid. *Cinnamic acid. *Chlorogenic acid ... Short-chain fatty acids[edit]. When fermentable fiber is fermented, short-chain fatty acids (SCFA) are produced. SCFAs are ... Almost all of these short-chain fatty acids will be absorbed from the colon. This means that fecal short-chain fatty acid ... The production of short-chain fatty acids has several possible actions on the gut mucosa. All of the short-chain fatty acids ...
Naturally occurring phenols
... chlorogenic, vanillic, caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p- ... Phenolic acids, Phenolic aldehydes Gallic, salicylic acids 8 C6-C2 1 Acetophenones, Tyrosine derivatives, Phenylacetic acids 3- ... Homogentisic acid 9 C6-C3 1 Hydroxycinnamic acids, Phenylpropenes, Coumarins, Isocoumarins, Chromones Caffeic, ferulic acids, ... Phenolic acids can be found in mushroom basidiomycetes species.[46] For example, protocatechuic acid and pyrocatechol are found ...
Taraxacum officinale
... and chlorogenic acid. Dandelion also contains terpenoids, triterpenes, and sesquiterpenes. Dandelion has been used as an herbal ... Dandelion contains flavonoids including luteolin, apigenin, isoquercitrin (a quercetin-like compound), caffeic acid, ...
Eggplant
... chlorogenic acid.[60] ...
پلیفنل - ویکیپدیا، دانشنامهٔ آزاد
α-Cyano-4-hydroxycinnamic acid. *Caffeic acid. *Cichoric acid. *Cinnamic acid. *Chlorogenic acid ... The gallic acid dimer, ellagic acid (M.W. 302, right), a molecule at the core of naturally occurring phenolic compounds of ... The raspberry ellagitannin (M.W. ~2450),[9] on the other hand, with its 14 gallic acid moieties (most in ellagic acid-type ... Plant-derived polyphenol, tannic acid, formed by esterification of ten equivalents of the phenylpropanoid-derived gallic acid ...
Calluna
The shoots of Calluna vulgaris contain the phenolic compounds chlorogenic acid, its 3-O-glucoside, 3-O-galactoside and 3-O- ... but has defeated many a gardener on less acid soil.[7] There are many named cultivars, selected for variation in flower colour ...
Dietary fiber
α-Cyano-4-hydroxycinnamic acid. *Caffeic acid. *Chicoric acid. *Cinnamic acid. *Chlorogenic acid ... Short-chain fatty acids[edit]. When fermentable fiber is fermented, short-chain fatty acids (SCFA) are produced.[14] SCFAs are ... Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (2005), ... One action of some fibers is to reduce the reabsorption of bile acids in the ileum and hence the amount and type of bile acid ...
Mate (drink)
On average, mate tea contains 92 mg of the antioxidant chlorogenic acid per gram of dry leaves, and no catechins, giving it a ...
Phenols
... chlorogenic, vanillic, caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p- ... 3-Acetyl-6-methoxybenzaldehyde, Tyrosol, p-Hydroxyphenylacetic acid, Homogentisic acid. 9. C6-C3. 1. Hydroxycinnamic acids, ... Phenolic acids, Phenolic aldehydes. Gallic, salicylic acids. 8. C6-C2. 1. Acetophenones, Tyrosine derivatives, Phenylacetic ... Phenolic acids can be found in mushroom basidiomycetes species.[59] For example, protocatechuic acid and pyrocatechol are found ...
Isosorbide mononitrate
The following adverse effects have been reported in studies with isosorbide mononitrate: Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3% of patients, but the incidence reduces rapidly as treatment continues.[7] Common: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified-release tablets, but at a frequency no greater than for placebo. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%)[7] Adverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. They occur mainly in the early stages of treatment.[7] Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. In general, these symptoms disappear during long-term treatment.[7] Other reactions that have been reported with isosorbide mononitrate-modified release tablets include tachycardia, vomiting, diarrhoea, vertigo, and heartburn.[7] ...
chlorogenic acid (CHEBI:16112)
... has functional parent trans-caffeic acid (CHEBI:16433) chlorogenic acid (CHEBI:16112) has role ... chlorogenic acid (CHEBI:16112) is a tannin (CHEBI:26848) chlorogenic acid (CHEBI:16112) is conjugate acid of chlorogenate ( ... chlorogenic acid (CHEBI:16112) has role plant metabolite (CHEBI:76924) chlorogenic acid (CHEBI:16112) is a cinnamate ester ( ... chlorogenic acid (CHEBI:16112) has functional parent (−)-quinic acid (CHEBI:17521) ...
Chlorogenic acid - Wikipedia
... chlorogenic acid is the ester formed between caffeic acid and the 3-hydroxyl of L-quinic acid. Isomers of chlorogenic acid ... caffeic acid, ferulic acid and p-coumaric acid) with quinic acid. Despite the "chloro" of the name, chlorogenic acids contain ... Isomers of chlorogenic acid are found in potatoes. Chlorogenic acid is present in the flesh of eggplants, peaches, prunes and ... Chlorogenic acid (CGA) is the ester of caffeic acid and (−)-quinic acid, functioning as an intermediate in lignin biosynthesis ...
chlorogenic acid - PMC - NCBI
... of chlorogenic acid; 5, H-6′ of chlorogenic acid; 6, H-3 of loganic acid; 7, H-5′ of chlorogenic acid and aromatic signals of ... "chlorogenic acid"[MeSH Terms] OR ("chlorogenic"[All Fields] AND "acid"[All Fields]) OR "chlorogenic acid"[All Fields]. Search. ... The peaks labelled with CGA are chlorogenic acid because the retention time was identical with that of chlorogenic acid ... STZ, streptozotocin; CGA10, chlorogenic acid 10 mg/kg; CGA20, chlorogenic acid 20 mg/kg. ...
chlorogenic acid | Science-Based Medicine
Chlorogenic Acid - Print Topic - Archive
To help me with this is been taking Chlorogenic Acid supplements. It seems to be helping. I did some studies on myself, and ... To help me with this is been taking Chlorogenic Acid supplements. It seems to be helping. I did some studies on myself, and ... http://www.lef.org/Vitamins-Supplements/Item01620/CoffeeGenic-Green-Coffee-Extract.html?source=search&key=chlorogenic%20acid ...
A scientific first? RCT supports cognitive benefits of chlorogenic acids
Chlorogenic acids - compounds found in coffee - may improve measures like cognitive performance and motor speeds, says a new ... Japanese researchers extracted Chlorogenic acids from green coffee beans. Image © Getty Images / Fydorov. Related tags: ... "Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial". Authors: K. Saitou ... Chlorogenic acids - compounds found in coffee - may improve measures like cognitive performance and motor speeds, says a new ...
Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. - PubMed - NCBI
Recently, cichoric acid (CHA) and chlorogenic acid (CGA) were predicted by docking methods to be allosteric inhibitors that ... Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid.. Lipchock JM1, ... Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid ... Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid ...
Bioavailability of Chlorogenic and Phenolic Acids From Soluble Coffees - Full Text View - ClinicalTrials.gov
Bioavailability of Chlorogenic and Phenolic Acids From Soluble Coffees. The safety and scientific validity of this study is the ... Composite of pharmacokinetics: AUC, Sum of AUC, Cmax, Tmax and T1/2 of plasma chlorogenic and phenolic acids from the other ... Composite of pharmacokinetics: sum of AUC of chlorogenic and phenolic acids the of extreme treatments. [ Time Frame: 18 months ... of this clinical trial is to investigate the possible difference in the bioavailability of chlorogenic and phenolic acids from ...
Chlorogenic Acid (CAS No 327-97-9) Manufacturers, Suppliers & Exporters
... chlorogenic acid manufacturers, chlorogenic acid suppliers and exporters. These chlorogenic acid manufacturing companies from ... Listed here is the database of chlorogenic acid, ... Chlorogenic acid, an ester of caffeic acid and quinic acid, is ... Name: Chlorogenic acid Synonyms: (1S,3R,4R,5R)-3-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5- ... We are prominent exporter of quality stock of Chlorogenic Acid in Xian, Shaanxi, China. Green coffee bean are coffee beans that ...
Nutrients | Free Full-Text | Bioavailability of Coffee Chlorogenic Acids and Green Tea Flavan-3-ols
Both the chlorogenic acids and the flavan-3-ols are absorbed in the small intestine and appear in the circulatory system ... Recent evidence indicates that some colon-derived phenolic acids have in vitro anti-inflammatory activity. ... This paper reviews recent human studies on the bioavailability of chlorogenic acids in coffee and green tea flavan-3-ols in ... Keywords: coffee; green tea; chlorogenic acids; flavan-3-ols; human bioavailability coffee; green tea; chlorogenic acids; ...
CAS No.327-97-9,Chlorogenic acid Suppliers
where to buy 327-97-9(Chlorogenic acid).Also offer free database of 327-97-9(Chlorogenic acid) including MSDS sheet(poisoning, ... Chlorogenic acid (8CI);Eucommia Leaf Extract;Chlorogenate;5-O-(3,4-Dihydroxycinnamoyl)-L-quinic acid;Chlorogenic acid 98% (UV); ... Chinese Natural Herbal Health Care Medicine of Chlorogenic Acid;3-O-Caffeoylquinic acid;HoneySuchle Flower Extract; ... 1. High quality 1.1 We can provide high purity Chlorogenic acid (90%, 98%) via of refining process with resin separation; 1.2 ...
Chlorogenic Acid Factory, China Chlorogenic Acid Factory Manufacturers & Suppliers | Made-in-China.com
Select 2017 high quality Chlorogenic Acid Factory products in best price from certified Chinese Malic Acid manufacturers, ... Eucommia Chlorogenic Acid suppliers, wholesalers and factory on Made-in-China.com ... Related Searches: Kojic Acid Malic Acid Eucommia Chlorogenic Acid Phosphorous Acid Citric Acid Monohydrate Arachidonic Acid ... Oxidizing Acid (1) Non Oxidizing Acid (1) Volatility Volatile Acid (1) Stability Stabilized Acid (1) ...
The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression
... Tian Yi Kang,1 ... A. L. Zhang, Q. Ma, and J. M. Gao, "Studies on bioactivities of chlorogenic acid and its analogues," Chinese Traditional and ... H. Kasai, S. Fukada, Z. Yamaizumi et al., "Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxy- ... H. Z. Wu, J. Luo, Y. X. Yin et al., "Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos ...
PRIME PubMed | Absorption of chlorogenic acid and caffeic acid in rats after oral administration
Absorption of chlorogenic acid and caffeic acid in rats after oral administration. Download Prime PubMed App to iPhone, iPad, ... Chlorogenic acid and caffeic acid are absorbed in humans.. *In vitro and in vivo antioxidant properties of chlorogenic acid and ... Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid ... Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid ...
Retracted: The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression
Journal of Analytical Methods in Chemistry has retracted the article titled "The Studies of Chlorogenic Acid Antitumor ... T. Y. Kang, H. R. Yang, J. Zhang et al., "The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The ... T. Y. Kang, H. R. Yang, J. Zhang et al., "Corrigendum to "The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip ... Retracted: The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression,. ...
Chlorogenic Acid: Health Benefits and Possible Side Effects
Read on to learn more about the potential benefits & side effects of chlorogenic acid. ... Chlorogenic acid is a natural antioxidant compound found in coffee beans. ... The caffeine in chlorogenic acid is linked mainly to drug interactions from chlorogenic acid. Before using a chlorogenic acid ... quinic acid produces chlorogenic acid.. Chlorogenic acids have been touted as having the ability to lower blood sugar levels ...
Scorzonera Sp. | Hepatoprotective Effect | Carbon Tetrachloride | Chlorogenic Acid
... chlorogenic acid, chlorogenic acid methyl ester, 1,5-dicaffeoyl quinic acid, 3,5-dicaffeoyl quinic acid, methylester of 3,5- ... Chlorogenic acid an ester of caffeic acid and quinic acid (3-O-caffeoylquinic acid (CGA)) possess significant antioxidant ... due to their chlorogenic acid contents. Derivatives of chlorogenic acid 3,4 and 3,5 dicaffeoylquinic acids were also reported ... activities due to their high content of chlorogenic acid as well as caffeoylquinic acid derivatives. Chlorogenic acid and ...
Chlorogenic Acid, 1 Oz, DesBio
Chlorogenic Acid by DesBio promotes optimal overall health and helps relieve congestion, fever and other symptoms. Place your ... Maintain Your Overall Health with Chlorogenic Acid. Chlorogenic acid is cinnamic acid derivative that is thought to provide a ... Maintain Your Overall Health with Chlorogenic Acid. Chlorogenic acid is cinnamic acid derivative that is thought to provide a ... Chlorogenic Acid. Product Approval Required: Call 1-800-673-1245 for a no-cost consultation. Already called? Login DesBio ...
The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures
Commercial whole coffee fruit extracts and powder samples were analyzed for chlorogenic acids (CGA), caffeine and antioxidant ... Three caffeoylquinic acids, three feruloylquinic acids, three dicaffeoylquinic acids, one p-coumaroylquinic acid, two ... The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures J Agric Food ... Commercial whole coffee fruit extracts and powder samples were analyzed for chlorogenic acids (CGA), caffeine and antioxidant ...
Human Metabolome Database: Showing metabocard for Chlorogenic acid (HMDB0003164)
Chlorogenic acid. Description. Chlorogenic acid is an ester of caffeic acid and quinic acid. Chlorogenic acid is the major ... Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid. The chlorogenic acid content of ... Kang J, Liu Y, Xie MX, Li S, Jiang M, Wang YD: Interactions of human serum albumin with chlorogenic acid and ferulic acid. ... Lafay S, Morand C, Manach C, Besson C, Scalbert A: Absorption and metabolism of caffeic acid and chlorogenic acid in the small ...
Chlorogenic acid induces death of breast cancer cells | PotatoPro
The researchers identified chlorogenic acid and neochlorogenic acid as the components responsible for killing the cancer cells ... The researchers identified chlorogenic acid and neochlorogenic acid as the components responsible for killing the cancer cells. ... This research is of interest to the Potato sector since potatoes are a significant source of chlorogenic acid. In the potato, ... A closer look at the extracts determined that two specific phenolic acid components - chlorogenic and neochlorogenic - were ...
Acute Effects of Decaffeinated Coffee and the Major Coffee Components Chlorogenic Acid and Trigonelline on Glucose Tolerance |...
Several mechanisms have been suggested for effects of chlorogenic acid on glucose metabolism. In vitro, chlorogenic acid has ... Chlorogenic acids and other cinnamates: nature, occurrence and dietary burden. J Sci Food Agric 1999; 79: 362- 372. ... RESULTS Chlorogenic acid and trigonelline ingestion significantly reduced glucose (−0.7 mmol/l, P = 0.007, and −0.5 mmol/l, P ... Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and ...
Nutrients | Free Full-Text | Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled...
1) Background: Chlorogenic acids (CGAs) have been attracting interest of late, owing to their health benefits. Here, we ... Ito, H.; Sun, X.L.; Watanabe, M.; Okamoto, M.; Hatano, T. Chlorogenic acid and its metabolite m-coumaric acid evoke neurite ... 1) Background: Chlorogenic acids (CGAs) have been attracting interest of late, owing to their health benefits. Here, we ... Chlorogenic acids (CGAs) are polyphenols abundant in coffee, which have been shown to be promising in preventing ...
Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats.
... the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic ... The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), ... 0/Antioxidants; 0/Caffeic Acids; 0/Coumaric Acids; 0/Hydroxybenzoic Acids; 29656-58-4/phenolic acid; 327-97-9/Chlorogenic Acid ... Chlorogenic Acid / metabolism*, pharmacokinetics. Coumaric Acids / administration & dosage. Hydrolysis. Hydroxybenzoic Acids / ...
Green Coffee Bean Extract | Chlorogenic Acid | Diet Support | bodykind Supplements
Green Coffee Extract contains high levels of chlorogenic acids and ideal for those following a calorie controlled weight loss ... Chlorogenic Acid. This contains high levels of chlorogenic acids and ideal for those following a calorie controlled weight loss ... Green Coffee Extract contains high levels of chlorogenic acids and ideal for those following a calorie controlled weight loss ... The extract used is decaffeinated and contains high levels of the active compounds called chlorogenic acids. Read more ...
Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? - Food & Function (RSC Publishing) DOI...
... chlorogenic acid) the related 3-CQA (neochlorogenic acid) and 4-CQA (cryptochlorogenic acid), all of which occur in coffee are ... 4 The main phenolic components in coffee are the chlorogenic acids (CGAs) among which the caffeoylquinic acids (CQAs), 5-CQA, 3 ... Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking?. Iziar A. Ludwig a, Pedro Mena b, Luca ... a Caffeine and chlorogenic acid levels expressed as mean values with standard error values ,7% of the mean in all instances (n ...
Chlorogenic acid chases glucose into muscle cells
Chlorogenic acid increases muscle cells insulin sensitivity and chases glucose into these cells. ... Chlorogenic acid is a prominent component of coffee and supplements that contain Green Coffee Bean extract. The compound might ... Chlorogenic acid. Chlorogenic acid is found in much of the food we eat. In fact, its probably the phenol we consume the most ... Red wine (contains chlorogenic acid) boosts testosterone level 10.10.2012. Prunes (contain chlorogenic acid) boost IGF-1 levels ...
Frontiers | Salinity Stress Is Beneficial to the Accumulation of Chlorogenic Acids in Honeysuckle (Lonicera japonica Thunb.) |...
Thus, salinity-induced chlorogenic acid accumulation in flower buds depended on an amplification effect of growth reduction. In ... Specifically, the total concentration of leaf chlorogenic acids was increased by 145.74% and 50.34% after 30 days of 150 and ... Similarly, the concentrations of chlorogenic acids were higher in the leaves of plants in saline, compared with non-saline, ... Specifically, the total concentration of leaf chlorogenic acids was increased by 145.74% and 50.34% after 30 days of 150 and ...
The modest fat loss effect of chlorogenic acid
Daily supplementation with 300 milligrams of chlorogenic acids - the bioactive substances in Green Coffee Bean extract - ... That could well be related to the phyochemical chlorogenic acid. Chlorogenic acid chases glucose into muscle cells. Chlorogenic ... "Consumption of high-chlorogenic acids coffee for 12 weeks by overweight adults might lower visceral fat area, total abdominal ... Coffee ingredient chlorogenic acid blocks insulins pro-aging effect. Coffee drinkers live a little longer than people who do ...
Effects of non-covalent interactions with 5-O-caffeoylquinic acid (chlorogenic a :: TNO Repository
Effects of non-covalent interactions with 5-O-caffeoylquinic acid (chlorogenic acid) on the heat denaturation and solubility of ... The non-covalent interactions between the monomeric phenolic compound chlorogenic acid (5-CQA) and bovine serum albumin (BSA), ... chlorogenic acid · globular protein · lysozyme · acidity · alkalinity · article · covalent bond · enthalpy · food · high ... Chlorogenic Acid · Drug Interactions · Heat · Hydrogen-Ion Concentration · Lactalbumin · Muramidase · Osmolar Concentration · ...
HPLCQuinicEffect of chlorogenic acidExtract ChlorogenicEffects of chlorogenicPolyphenolsContain chlorogenic acidPowderHigh-performance liCGAsExtractsFeruloylquinic acidsPolyphenolDicaffeoylquinic acidsCompoundsMain phenolicHoneysuckleParticularly rich in chlorogenicMetabolismFerulic acidsShow that chlorogenic acidCaffeine and chlorogenic acidSuggest that chlorogenic acidAbstractPlant ExtractGreen Coffee ExtractBioavailability of ChlorogenicIntermediate in lignin biosynthesisPhenolic acidRatsIngestion of chlorogenicFlavonoidsSmall intestineCaffeoylquinic acidsPharmacokineticsAntioxidant ActivityCoffeeAntioxidantsNeochlorogenic acidOxidative StressAmountsInhibitoryVitroGlucoseLactonesInhibitionResearchersSupplementsInflammationAbsorptionPotent antioxidant
HPLC5
- Objective] To establish a method for determining contents of chlorogenic acid in different organs from Taraxacum mongolicum by HPLC. (cnki.com.cn)
- Method] The HPLC was carried out with Shim-pack VP-ODS column(4.6 mm×150.0 mm,5 μm) using mixture of methanol and 0.4 % phosphoric acid solution in different ratio as mobile phase.Other conditions were: flow rate of 1.0 ml/min,detection wavelength of 326 nm,column temperature of 40 ℃ and sampling amount of 20 μl. (cnki.com.cn)
- In this study, we observed the protective effect of Lycium barbarum L. extract on RGCs in rats with persistent ocular hypertension and made qualitative and quantitative analyses on chlorogenic acid in the extract by RP-HPLC technique. (alliedacademies.org)
- Gymnema Sylvestre Extract Product Name: Gymnema sylvestre Extract Botanical Name: Gymnema sylvestre .L Part Used : Stem and leaf Specification: 25%, 50% Gymnemic Acids Test method: HPLC CAS No.: 90045-47-9 Molecular Formula: C43H66O14 Molecular. (sino-excellent.com)
- Echinacea Extract Latin name: Echinacea Purpurea extract Part used: overground part Appearance: Greenish yellow fine powder Specification: cichoric acid 1%,2%,4% HPLC Packing: packed in paper-drum and two plastic-bag inside. (sino-excellent.com)
Quinic20
- A cinnamate ester obtained by formal condensation of the carboxy group of trans -caffeic acid with the 3-hydroxy group of quinic acid. (ebi.ac.uk)
- Chlorogenic acid (CGA) is the ester of caffeic acid and (−)-quinic acid, functioning as an intermediate in lignin biosynthesis. (wikipedia.org)
- The term "chlorogenic acids" refers to a related polyphenol family of esters, including hydroxycinnamic acids (caffeic acid, ferulic acid and p-coumaric acid) with quinic acid. (wikipedia.org)
- Structurally, chlorogenic acid is the ester formed between caffeic acid and the 3-hydroxyl of L-quinic acid. (wikipedia.org)
- Isomers of chlorogenic acid include the caffeoyl ester at other hydroxyl sites on the quinic acid ring: 4-O-caffeoylquinic acid (cryptochlorogenic acid or 4-CQA) and 5-O-caffeoylquinic acid (neochlorogenic acid or 5-CQA). (wikipedia.org)
- The order of numbering of atoms on the quinic acid ring was reversed in 1976 following IUPAC guidelines, with the consequence that 3-CQA became 5-CQA, and 5-CQA became 3-CQA. (wikipedia.org)
- Another switchgrass hydroxycinnamoyl transferase, PvHCT-Like1, is phylogenetically distant from HCTs or HQTs, but exhibits HQT activity, preferring quinic acid as acyl acceptor, and could therefore function in CGA biosynthesis. (springer.com)
- 5-O-(3,4-Dihydroxycinnamoyl)-L-quinic acid Molecular Formula C16H18O9 Molecular Weight 354.31 Specifications AVAILABLE. (tradeindia.com)
- The etherification of cinnamic acids such as ferulic , p-coumaric acids , and caffeic with (-)-quinic acid produces chlorogenic acid. (consumerhealthdigest.com)
- Chlorogenic acid is an ester of caffeic acid and quinic acid. (hmdb.ca)
- This compound belongs to the class of chemical entities known as quinic acids and derivatives. (hmdb.ca)
- These are compounds containing a quinic acid moiety (or a derivative thereof), which is a cyclitol made up of a cyclohexane ring that bears four hydroxyl groups at positions 1,3.4, and 5, as well as a carboxylic acid at position 1. (hmdb.ca)
- Chlorogenic acid (CGA) is a natural chemical compound which is the ester of caffeic acid and (-)quinic acid. (kitairu.net)
- That specific flavour is caused by a chemical compound known as chlorogenic acid which is found in abundance in coffee beans and is just one of the many acids that coffee beans contain such as lactic, malic, quinic, citric, and acetic acids. (greencoffeereport.org)
- Once digested, our body metabolizes these acids in two types: caffeic and quinic acid . (greencoffeereport.org)
- Chlorogenic acid is a group of esters created from trans-cinnamic acids and quinic acids that has many health benefits. (reference.com)
- Three instant coffee extracts (light roast, dark roast, decaffeinated dark roast) and six coffee components [caffeine ( 1 ), chlorogenic acid ( 2 ), quinic acid ( 3 ), caffeic acid ( 4 ), quercetin ( 5 ), and phenylindane ( 6 )] were investigated for their ability to inhibit the fibrillization of Aβ and tau proteins using thioflavin T (ThT) and thioflavin S (ThS) fluorescence assays, respectively. (frontiersin.org)
- On average, people consume about 10 times more polyphenols than they do vitamin C. Coffee contains a type of polyphenol called chlorogenic acids, which are esters of quinic and cinnamic acids. (livestrong.com)
- Chlorogenic acid (CGA) is an ester formed from cinnamic acids and quinic acid and is also known as 5-O-caffeoylquinic acid (5-CQA) (IUPAC numbering) or 3-CQA (pre-IUPAC numbering) [ 7 ] . (eco-supplements.com)
- Chemically, it is an ester formed from quinic acid and two units of caffeic acid. (wikipedia.org)
Effect of chlorogenic acid4
- Effect of chlorogenic acid on hydroxyl radical. (cdc.gov)
- Pharmacologists at the National University of Singapore wanted to find out more about the effect of chlorogenic acid on the way insulin works, so they did a series of experiments using muscle cells from overweight mice that had type-2 diabetes. (ergo-log.com)
- In the present study, the inhibitory effect of chlorogenic acid (CGA), a phenolic compound with potential antitumor effects, on circulating microRNA 31 (miR‑31), was evaluated in RKO colon cancer cells. (spandidos-publications.com)
- Its protective property might be due to the presence of a mitochondrial-targeted antioxidant effect of chlorogenic acid. (begellhouse.com)
Extract Chlorogenic3
- 1.Green Coffee Bean Extract Chlorogenic acid, long known as an antioxidant with potential anti-cancer activity, also slows the release of glucose into bloodstream after a meal. (kitairu.net)
- As a natural plant extract, chlorogenic acid and other natural polyphenols can not only excellently protect collagen against the damage of reactive oxygen and other free radicals, but also effectively prevent human skin from the harmful effects resulted from UV radiation. (newleafherb.com)
- Coffee Bean Extract, Chlorogenic Acid, Herbal Extract manufacturer / supplier in China, offering Weight Loss Green Coffee Bean Extract Chlorogenic Acid, Styptic High Quality Couch Grass Extract/Arundoin, 10: 1 20: 1, Antineoplastic Natural Ligustrum Lucidum Extract 98% Oleanolic Acid and so on. (made-in-china.com)
Effects of chlorogenic8
- Suppressive effects of chlorogenic acid on N-methyl-N-nitrosourea-indueed glandular stomach carcinogenesis in male F344 rats," Toxicological Sciences , vol. 24, no. 5, pp. 433-439, 1999. (hindawi.com)
- Inhibitory effects of chlorogenic acid on azoxymethane-induced colon carcinogenesis in male F344 rats," Asian Pacific Organization for Cancer Prevention , vol. 3, no. 2, pp. 163-166, 2002. (hindawi.com)
- Read on to learn more about the potential benefits and side effects of chlorogenic acid. (consumerhealthdigest.com)
- This is the first study to investigate the acute effects of chlorogenic acid and trigonelline on glucose tolerance in humans. (diabetesjournals.org)
- This systematic review discusses in vivo animal and human studies of the physiological and biochemical effects of chlorogenic acids (CGAs) on biomarkers of chronic disease. (nih.gov)
- To investigate the mechanism of the combined effects of chlorogenic acid (CGA) and caffeine on lipid metabolism in high-fat diet-induced obese mice, eighty female ICR mice were randomly divided into eight groups and fed with a high-fat diet with/without CGA and/or caffeine for 14 weeks. (rsc.org)
- Objective The current study investigates the effects of protective effects of chlorogenic acid (CGA) on d-galactose-induced liver and kidney injury. (edu.au)
- Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. (medchemexpress.com)
Polyphenols2
- A series of experiments reported in the scientific journal 'Circulation Research' focuses on two polyphenols in coffee, caffeic and ferulic acids. (livestrong.com)
- Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. (abmole.com)
Contain chlorogenic acid2
- Coffee beans contain chlorogenic acid, a natural antioxidant molecule. (consumerhealthdigest.com)
- If you want to make a bigger impact on metabolism, consider supplements that contain chlorogenic acid and caffeine. (livestrong.com)
Powder5
- Commercial whole coffee fruit extracts and powder samples were analyzed for chlorogenic acids (CGA), caffeine and antioxidant activities. (nih.gov)
- What is Green Coffee Bean Extract Powder Chlorogenic Acid? (kitairu.net)
- is 500 grams (1.1 lb, 17.6 oz) Green Coffee Bean Extract Powder (standardized 50% Chlorogenic Acid). (herbstoreusa.com)
- For supplement purpose, daily dose for general adult is a flat 1/4 teaspoon powder (425 mg powder, resulting 215 mg chlorogenic acid and 19 mg caffeine) with water or beverage, 1 to 2 times daily. (herbstoreusa.com)
- Pure Green Coffee Bean Extract bulk Powder, standardized 50% Chlorogenic Acid, with top quality at low price from $15.95. (herbstoreusa.com)
High-performance li1
- Phytochemical analysis using high-performance liquid chromatography revealed the presence of chlorogenic acid in the extracts. (begellhouse.com)
CGAs6
- Sixteen weeks of supplementation with 300 mg per day of chlorogenic acids (CGAs) were associated with significant improvements in motor speed, psychomotor speed, and executive function, compared with placebo. (nutraingredients.com)
- Analysis showed that the CGAs in the extract were caffeoylquinic acids (CQAs), feruloylquinic acids (FQAs), and dicaffeoylquinic acids (diCQAs). (nutraingredients.com)
- 1) Background: Chlorogenic acids (CGAs) have been attracting interest of late, owing to their health benefits. (mdpi.com)
- 4 The main phenolic components in coffee are the chlorogenic acids (CGAs) among which the caffeoylquinic acids (CQAs), 5-CQA, 3-CQA and 4-CQA ( Fig. 1 ) dominate along with lower amounts of feruloylquinic acids and dicaffeoylquinic acids. (rsc.org)
- We searched PubMed, Embase, Amed and Scopus using the following search terms: ("chlorogenic acid" OR "green coffee bean extract") AND (human OR animal) (last performed on April 1st, 2015) for relevant literature on the in vivo effects of CGAs in animal and human models, including clinical trials on cardiovascular, metabolic, cancerogenic, neurological and other functions. (nih.gov)
- Using a cultured gastric epithelial model, with an acidic apical pH, the relative permeability coefficients ( P app ) and metabolic fate of a series of chlorogenic acids (CGAs) were investigated. (aspetjournals.org)
Extracts3
- jacquiniana roots, methanol-water (80:20) extracts together with chlorogenic acid, scorzotomentosin-4'-O-β-glucoside, hydrangenol-8-O-β-glucoside as major compounds isolated from S. latifolia roots were tested for their hepatoprotective activities. (ijpsonline.com)
- A closer look at the extracts determined that two specific phenolic acid components - chlorogenic and neochlorogenic - were responsible for killing the cancer cells while not affecting the normal cells, Cisneros-Zevallos said. (potatopro.com)
- Hano, C. Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast. (preprints.org)
Feruloylquinic acids2
- Three caffeoylquinic acids, three feruloylquinic acids, three dicaffeoylquinic acids, one p-coumaroylquinic acid, two caffeoylferuloylquinic acids and three putative chlorogenic lactones were quantified, along with a methyl ester of 5-caffeoylquinic acid (detected in one sample, the first such report in any coffee material). (nih.gov)
- For the first time, we show intact absorption of feruloylquinic acids and caffeoylquinic acid lactones across the gastric epithelium ( P app ∼ 0.2 cm/s). (aspetjournals.org)
Polyphenol6
- Chlorogenic acid (CGA), an important biologically active dietary polyphenol, is produced by certain plant species and is a major component of coffee. (nih.gov)
- Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. (edu.au)
- 5-O-caffeoylquinic acid is the most abundant polyphenol present in coffee. (livestrong.com)
- Chlorogenic acid (CGA), one of the most abundant polyphenol compounds in the human diet, is a group of phenolic secondary metabolites produced by certain plant species and is an important component of coffee. (eco-supplements.com)
- Therapies with novel mechanisms of action to combat glucose and lipid metabolic disorders would therefore have significant medical and economic impacts.Chlorogenic acid (CGA) ( Figure 1 ), one of the most abundant polyphenol compounds in the human diet, is a group of phenolic secondary metabolites produced by certain plant species and an important component of coffee. (eco-supplements.com)
- Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. (abmole.com)
Dicaffeoylquinic acids1
- Each coffee bean will have traces of feruloyquinic, coumaroylquinic and dicaffeoylquinic acids. (greencoffeereport.org)
Compounds8
- Chlorogenic acid and the related compounds cryptochlorogenic acid, and neochlorogenic acid have been found in the leaves of Hibiscus sabdariffa. (wikipedia.org)
- Chlorogenic acids - compounds found in coffee - may improve measures like cognitive performance and motor speeds, says a new study from Japan's Kao Corporation. (nutraingredients.com)
- This paper reviews recent human studies on the bioavailability of chlorogenic acids in coffee and green tea flavan-3-ols in which the identification of metabolites, catabolites and parent compounds in plasma, urine and ileal fluid was based on mass spectrometric methodology. (mdpi.com)
- Chlorogenic acid, among tested compounds exhibited higher activity than all tested Scorzonera species as well as other isolated compounds. (ijpsonline.com)
- Therefore chlorogenic acid could be suggested as responsible compounds. (ijpsonline.com)
- The extract used is decaffeinated and contains high levels of the active compounds called chlorogenic acids. (bodykind.com)
- is a traditional medicinal plant in China that is particularly rich in chlorogenic acids, which are phenolic compounds with various medicinal properties. (frontiersin.org)
- One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. (current-neuropharmacology.com)
Main phenolic2
- The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is directly absorbed or hydrolysed in the small intestine. (biomedsearch.com)
- The main phenolic acids in WF were trans- and cis-ferulic acids (257 and 165.57mg/100g dw, respectively). (scienceopen.com)
Honeysuckle6
- Salinity Stress Is Beneficial to the Accumulation of Chlorogenic Acids in Honeysuckle (Lonicera japonica Thunb. (frontiersin.org)
- This study aimed to examine the effects of salinity stress on accumulation of chlorogenic acids in honeysuckle, through hydroponic experiments and field trials, and to examine the mechanisms underlying the effects. (frontiersin.org)
- Soil salinity also led to elevated chlorogenic acid concentrations in honeysuckle flower buds, with significant increases in total chlorogenic acids concentration of 22.42 and 25.14% in May 2014 and 2015, respectively. (frontiersin.org)
- In conclusion, salinity stress improved the medicinal quality of honeysuckle by promoting accumulation of chlorogenic acids, however, the mechanisms underlying this process were not consistent in flower buds and leaves. (frontiersin.org)
- Detection of Chlorogenic Acid in Honeysuckle Using Infrared-Assisted Extraction Followed by Capillary Electrophoresis with UV Detector. (ebscohost.com)
- In this study, a novel infrared-assisted extraction method coupled capillary electrophoresis (CE) is employed to determine chlorogenic acid from a traditional Chinese medicine (TCM), honeysuckle. (ebscohost.com)
Particularly rich in chlorogenic1
- The almond skin enriched fraction obtained from cold-pressed oil residues of the endemic Moroccan Beldi ecotypes is particularly rich in chlorogenic acid. (preprints.org)
Metabolism8
- These findings underscore the important role that chlorogenic acid and chromium play in maintaining glucose metabolism and insulin response in mice fed a high-fat diet. (sigmaaldrich.com)
- Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats. (biomedsearch.com)
- In addition, analysis of the expression of energy metabolism-related genes in the liver revealed significantly decreased messenger RNA expression of stearoyl-CoA desaturase 1, acetyl-CoA carboxylase 1 (ACC1), and ACC2, which are involved in fatty-acid oxidation, after mice were administered green coffee bean extract containing chlorogenic acids for two weeks. (ergo-log.com)
- SCOPE Until now, the question of how the ingested doses of chlorogenic acids (CGA) from coffee influence their absorption and metabolism remains unresolved. (semanticscholar.org)
- Gonthier M.P., Verny M.A., Besson C., Remesy C., Scalbert A. (2003) Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. (phenol-explorer.eu)
- Consuming the recommended amount of coconut oil provides the body with sufficient lauric acid to remove and prevent infections, as well as increases metabolism. (reference.com)
- Some metabolism-boosting supplements contain green coffee bean extract, which consists of the active ingredient chlorogenic acid. (livestrong.com)
- Chlorogenic acid primarily increases fat metabolism. (livestrong.com)
Ferulic acids2
- On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. (unboundmedicine.com)
- Mechanism of action and interactions between xanthine oxidase inhibitors derived from natural sources of chlorogenic and ferulic acids. (scienceopen.com)
Show that chlorogenic acid2
- The present results show that chlorogenic acid is absorbed and hydrolysed in the small intestine. (biomedsearch.com)
- The researchers were able to show that chlorogenic acid activated the glucose transporter GLUT4 via AMPK. (ergo-log.com)
Caffeine and chlorogenic acid1
- Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? (rsc.org)
Suggest that chlorogenic acid1
- These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms. (unboundmedicine.com)
Abstract1
- abstract = "We have investigated the Raman spectra of different regioisomeric forms of monoacyl and diacyl chlorogenic acids. (umn.edu)
Plant Extract1
- Chlorogenic acid is a commonly used plant extract mainly from Lonicera japonica Thumb, Lonicera hypoglauca Miq. (newleafherb.com)
Green Coffee Extract4
- Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans. (consumerhealthdigest.com)
- Green coffee extract is the most frequent type of chlorogenic acid supplementation. (consumerhealthdigest.com)
- Green Coffee Extract contains high levels of chlorogenic acids and ideal for those following a calorie controlled weight loss diet. (bodykind.com)
- Natures Aid Green Coffee Extract is a decaffeinated Green Coffee Bean Extract this provides a guaranteed minimum 45% Chlorogenic Acid. (bodykind.com)
Bioavailability of Chlorogenic1
- The main objective of this clinical trial is to investigate the possible difference in the bioavailability of chlorogenic and phenolic acids from coffee at various roasting levels. (clinicaltrials.gov)
Intermediate in lignin biosynthesis1
- Chlorogenic acid is an important intermediate in lignin biosynthesis. (kitairu.net)
Phenolic acid1
- Gallic Acid is a trihydroxybenzoic acid, a type of phenolic acid. (thomassci.com)
Rats8
- Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. (unboundmedicine.com)
- Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. (unboundmedicine.com)
- Short-chain fatty acid formation in the hindgut of rats fed native and fermented oat fibre concentra. (biomedsearch.com)
- Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of stable isotopes and inductively-coupled plasma mass spectrometry technique. (biomedsearch.com)
- Zn absorption was significantly less in rats fed on chlorogenic acid or caffeic acid than in the control group. (biomedsearch.com)
- Rats were randomized into Control (C), Model (M), Chlorogenic Acid and Geniposide (CG), Pioglitazone (PH) and Bifico (B) groups. (researchsquare.com)
- While it hasn't been studied in people, when lab rats consumed chlorogenic acid and caffeine, they lost more weight than rats taking either ingredient alone, reported the British Journal of Nutrition in September 2014. (livestrong.com)
- Chlorogenic acid (CGA) at a dose of 5 mg/kg body weight exerts antidiabetic potential in streptozotocin (STZ) (45 mg/kg b.w.) nicotinamide induced diabetic rats [ 31 - 33 ] . (eco-supplements.com)
Ingestion of chlorogenic1
- This effect, however, was only detected in far greater concentrations than those found in human blood following ingestion of chlorogenic acid. (consumerhealthdigest.com)
Flavonoids4
- In contrast to numerous flavonoids, absorbed phenolic acids are poorly excreted in the bile or gut lumen. (biomedsearch.com)
- 2002/Nr 4] Quantitative determination of coumarins, flavonoids and chlorogenic acid in the. (ptfarm.pl)
- Quantitative determination of coumarins, flavonoids and chlorogenic acid in the leaves and underground parts of some species of genus Scopolia JACQ. (ptfarm.pl)
- It mainly contains polysaccharides, betaine, flavonoids and phenolic acids [ 4 - 6 ]. (alliedacademies.org)
Small intestine4
- Both the chlorogenic acids and the flavan-3-ols are absorbed in the small intestine and appear in the circulatory system predominantly as glucuronide, sulfate and methylated metabolites. (mdpi.com)
- Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. (unboundmedicine.com)
- Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists. (semanticscholar.org)
- Chlorogenic acid was shown to have an antagonistic effect on glucose transport and also has been found to significantly delay glucose uptake from the small intestine. (pe-factory.com)
Caffeoylquinic acids2
- The effect of roasting of coffee beans and the extraction of ground coffee with different volumes of hot pressurised water on the caffeine and the total caffeoylquinic acids (CQAs) content of the resultant beverages was investigated. (rsc.org)
- In contrast, absorption of intact di- O -caffeoylquinic acids was rapid ( P app ∼ 2-10 cm/s) but nonlinear with respect to time and concentration dependence, which was potentially limited by interaction with an efflux transporter and/or pH gradient dependence. (aspetjournals.org)
Pharmacokinetics2
- Composite of pharmacokinetics: sum of AUC of chlorogenic and phenolic acids the of extreme treatments. (clinicaltrials.gov)
- Composite of pharmacokinetics: AUC, Sum of AUC, Cmax, Tmax and T1/2 of plasma chlorogenic and phenolic acids from the other treatments. (clinicaltrials.gov)
Antioxidant Activity3
- accordingly, the concentrations of chlorogenic acids in leaves were significantly increased under NaCl stress, as was antioxidant activity. (frontiersin.org)
- A test in vitro antiproliferative activity of chlorogenic acid found in respect of a human tumor cell line ( A549 ) , which can not be explained with the sole antioxidant activity. (bamboolifetree.co.uk)
- It should be noted that even the non-absorbed fraction of chlorogenic acid can still perform its antioxidant activity and protective at the level of the digestive tract , protecting against oxidative damage and therefore the risk of cancer of the stomach and intestines. (bamboolifetree.co.uk)
Coffee44
- Structures having more than one caffeic acid group are called isochlorogenic acids, and can be found in coffee. (wikipedia.org)
- Chlorogenic acid is present in the flesh of eggplants, peaches, prunes and coffee beans. (wikipedia.org)
- Taken as a dietary supplement or in coffee, chlorogenic acid slightly reduces blood pressure. (wikipedia.org)
- Chlorogenic acid is a natural antioxidant compound found in coffee beans. (consumerhealthdigest.com)
- Chlorogenic acid, an antioxidant-rich phytochemicals found in green coffee and coffee beans, is a powerful antioxidant. (consumerhealthdigest.com)
- Chlorogenic acid is found in coffee beans and various forms of coffee, including green coffee . (consumerhealthdigest.com)
- Green coffee bean extract, a natural source of chlorogenic acid, has been linked to some allergies. (consumerhealthdigest.com)
- This effect appears to be caused by coffee components other than chlorogenic acid. (consumerhealthdigest.com)
- Although chlorogenic acid (CGA) has stimulant properties, it is believed to be one-third less powerful than coffee. (consumerhealthdigest.com)
- Chlorogenic acid is the major polyphenolic compound in coffee, isolated from the leaves and fruits of dicotyledonous plants. (hmdb.ca)
- Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid. (hmdb.ca)
- The chlorogenic acid content of a 200 ml (7-oz) cup of coffee has been reported to range from 70-350 mg, which would provide about 35-175 mg of caffeic acid. (hmdb.ca)
- RESEARCH DESIGN AND METHODS We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men. (diabetesjournals.org)
- Coffee is a major source of the phenolic compound chlorogenic acid ( 6 ) and the vitamin B3 precursor trigonelline ( 7 ), which have been shown to reduce blood glucose concentrations in animal studies ( 5 - 8 ). (diabetesjournals.org)
- Four supplements were tested in this crossover trial: 12 g decaffeinated coffee (Nescafé Gold, Nestlé, the Netherlands), 1 g chlorogenic acid (Sigma Aldrich, Switzerland), 500 mg trigonelline (Sigma Aldrich), and 1 g mannitol as placebo (Spruyt Hillen Bufa, the Netherlands). (diabetesjournals.org)
- Based on laboratory measurements ( 9 , 10 ), the decaffeinated coffee used in our study provided 264 mg chlorogenic acid and 72 mg trigonelline. (diabetesjournals.org)
- Fig. 1 Using the preferred IUPAC numbering 5 the structures of 5-CQA (chlorogenic acid) the related 3-CQA (neochlorogenic acid) and 4-CQA (cryptochlorogenic acid), all of which occur in coffee are illustrated. (rsc.org)
- Chlorogenic acid [structural formula below] is a prominent component of coffee and supplements that contain Green Coffee Bean extract. (ergo-log.com)
- Drinking coffee protects against type-2 diabetes, and nutritionists suspect that this protective effect is partly due to chlorogenic acid. (ergo-log.com)
- Daily supplementation with 300 milligrams of chlorogenic acids - the bioactive substances in Green Coffee Bean extract - can slightly reduce the amount of belly fat. (ergo-log.com)
- One group received regular instant coffee, the other coffee to which the researchers had added around 300 milligrams of chlorogenic acid analogues. (ergo-log.com)
- Besides caffeine, chlorogenic acid analogues are the most important bioactive constituents of coffee. (ergo-log.com)
- According to a human clinical trial comparing daily consumption of roasted coffee containing 359 mg chlorogenic acids and placebo coffee for one week, repeated consumption of chlorogenic acids decreased the respiratory quotient and increased oxygen consumption, which means that both energy expenditure and fat oxidation were increased. (ergo-log.com)
- Furthermore, feeding green coffee bean extract containing chlorogenic acids to mice with diet-induced obesity affects body fat accumulation, with a dose-dependent inhibition of the increase in body weight and accumulation of visceral fat and liver fat. (ergo-log.com)
- Consumption of high-chlorogenic acids coffee for 12 weeks by overweight adults might lower visceral fat area, total abdominal fat area, BMI, and waist circumference ", conclude the researchers. (ergo-log.com)
- We propose that the stomach is the first location for the release of hydroxycinnamic acids, which could explain their early detection after coffee consumption. (aspetjournals.org)
- green coffee beans p.e., the weight loss is due to chlorogenic acid, which is thought to reduce the absorption of glucose and lower the hyperglycemic peak. (diytrade.com)
- This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on postexercise inflammation and oxidative stress, with secondary outcomes including performance and mood state. (uncg.edu)
- No differences between CQA coffee and placebo were found for postexercise increases in plasma IL-6 (p = .74) and hydroxyoctadecadienoic acids (9 + 13 HODEs) (p = .99). (uncg.edu)
- In summary, despite more favorable TMD scores with CQA coffee, these data do not support the chronic use of coffee highly concentrated with chlorogenic acids and caffeine in mitigating postexercise inflammation or oxidative stress or improving 50-km cycling performance. (uncg.edu)
- Start your review of Super Garcinia Cambogia 300 Liquid (50% HCA) with Green Coffee Bean Extract (50% Chlorogenic Acid) Weight Loss Diet Drops - 2fl Oz (60ml)! (influenster.com)
- The roasting process does not influence the extent of conjugation of coffee chlorogenic and phenolic acids. (semanticscholar.org)
- In vitro studies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds. (semanticscholar.org)
- Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration. (semanticscholar.org)
- Chlorogenic acids-present in coffee, fruits, and vegetables-was associated with a lower incidence of breast cancer among postmenopausal women. (greenmedinfo.com)
- Within a coffee bean is a CGA called 5-caffeoylquinic acid. (greencoffeereport.org)
- 50 % Chlorogenic Acid Green Coffee cod. (bamboolifetree.co.uk)
- Ingredients for 1 vegetarian capsule : Coffee- Only Pure dry extract titrated green seeds ( Coffee arabica L.) 490 mg - (Title 50 % Chlorogenic Acid , intake of 245 mg). (bamboolifetree.co.uk)
- The molecule of chlorogenic acid , commonly prevalent in foods such as coffee and certain plants, collecting special interest in nutrition and has been studied for its antioxidant , antibacterial and antiviral properties , and in general for potentially preventive activity against tumor diseases , cardiovascular disease and diabetes. (bamboolifetree.co.uk)
- One candidate is trigonelline, a nicotinic acid in coffee that lowers blood sugar in animal studies. (livestrong.com)
- Green Coffee Bean is a powerful antioxidant and its chlorogenic acids advances weight loss by decreasing the rate of fat absorption from food, cutting down fat storage in the liver, and enhancing the fat burning capacity of the hormone adiponectin. (herbadiet.in)
- Our Green Coffee contains a super high-potency extract of Coffea Robusta beans standardized for 50% Chlorogenic Acid & is lab tested for potency and purity. (herbadiet.in)
- Chlorogenic acid is a major phenolic compound in coffee and tea. (medchemexpress.com)
- Green Coffee Bean P.E. 45% Chlorogenic Acid is thought to have antioxidant and anti-inflammatory properties. (ingredientsonline.com)
Antioxidants2
- Applied Food Sciences Inc. (AFS) is pleased to announce it is the exclusive owner of U.S. Patent #9345707, a process patent that covers the production of enriched natural guayusa, from a single source plant, containing antioxidants, amino acids and caffeine. (naturalproductsinsider.com)
- Laboratory studies have shown that chlorogenic acid contains high amount of antioxidants. (greencoffeereport.org)
Neochlorogenic acid2
- This article uses the original numbering, which was exclusive prior to 1976, (chlorogenic acid being 3-CQA, while neochlorogenic acid is 5-CQA). (wikipedia.org)
- The researchers identified chlorogenic acid and neochlorogenic acid as the components responsible for killing the cancer cells. (potatopro.com)
Oxidative Stress2
- Chlorogenic acid, on the other hand, has been shown in recent research to boost mood, reduce oxidative stress , and lower blood sugar levels. (consumerhealthdigest.com)
- Chlorogenic acid (CGA) has been demonstrated to possess potent neuroprotective activities against oxidative stress in various cellular models and pathological conditions. (springer.com)
Amounts4
- No chlorogenic acid was detected in either plasma or bile, and only low amounts of phenolic acids (less than 0.4 %) were secreted in the bile. (biomedsearch.com)
- Despite leaf biomass reduction, absolute amounts of chlorogenic acids per plant and phenylalanine ammonia-lyase (PAL) activity were significantly increased by soil salinity, confirming that the accumulation of chlorogenic acids in leaves was a result of stimulation of their synthesis under salinity stress. (frontiersin.org)
- Consistent with biomass reduction, the absolute amounts of chlorogenic acid per plant declined in flower buds of plants exposed to elevated soil salinity, with no significant change in PAL activity. (frontiersin.org)
- Apples contain small amounts of chlorogenic acid. (marshallprotocol.com)
Inhibitory3
- γ-aminobutyric acid(GABA) γ-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system. (sino-excellent.com)
- The chlorogenic acid of Eucommia ulmoides Oliv has strong anti-inflammatory and anti-inflammatory effects, and the anthocyanins and their polymers have obvious bacteriostasis, and the anthocyanins have inhibitory effect on Gram-negative and positive bacteria. (natural-ingredient.com)
- Chlorogenic Acids is thought to exert an inhibitory effect on fat accumulation and may have an appetite suppressing effect. (ingredientsonline.com)
Vitro7
- Recent evidence indicates that some colon-derived phenolic acids have in vitro anti-inflammatory activity. (mdpi.com)
- Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxy-deoxyguanseine formation in vitro and in a rat carcinogenesis mode1," Food and Chemical Toxicology , vol. 38, no. 5, pp. 467-471, 2000. (hindawi.com)
- Experimental study on the induction of a-tinterferon of human leucocyte in vitro by chlorogenic acid," Journal of Harbin Medical University , vol. 38, pp. 120-122, 2004. (hindawi.com)
- According to this in-vitro study carnosic acid helps muscle cells to absorb more glucose. (ergo-log.com)
- In vitro transformation of chlorogenic acid by human gut microbiota. (semanticscholar.org)
- In vitro tests have demonstrated for chlorogenic acid , caffeic acid and the like for the ferulic acid , the ability to inhibit the reaction between nitrite and secondary amines or tertiary amines to form nitrosamines , strongly carcinogenic for the liver and kidneys ( Kono et al. (bamboolifetree.co.uk)
- Chlorogenic acid inhibited the proliferation of A549 human cancer cells in vitro.Chlorogenic acid suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ cells in a dose-dependent manner.Chlorogenic acid also increased the enzymatic activities of glutathione S-transferases (GST) and NAD(P)H: quinone oxidoreductase. (abmole.com)
Glucose7
- RESULTS Chlorogenic acid and trigonelline ingestion significantly reduced glucose (−0.7 mmol/l, P = 0.007, and −0.5 mmol/l, P = 0.024, respectively) and insulin (−73 pmol/l, P = 0.038, and −117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. (diabetesjournals.org)
- CONCLUSIONS Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT. (diabetesjournals.org)
- Chlorogenic acid increases muscle cells' insulin sensitivity and chases glucose into these cells. (ergo-log.com)
- Administering chlorogenic acid boosted the glucose uptake, certainly when combined with insulin. (ergo-log.com)
- Loquat leaf extract contains a triterpenoid compound known as corosolic acid which has actions in stimulating glucose transport into cells. (chinaplantextract.com)
- Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. (biomedcentral.com)
- That is Green Coffe Bean Extrac , the weight loss is due to chlorogenic acid, which is thought to reduce the absorption of glucose and lower the hyperglycemic peak.The indications for use of this supplement are: Obesity, low MBR, cellulite and extra weight. (pe-factory.com)
Lactones10
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- Formation aiming at the person lying in Of the groove and scanning Chlorogenic from head to toe Normal scanning Acid only takes Lactones Formation Of Chlorogenic Acid Lactones more than ten minutes, but Erics situation is different. (triangleliteracy.org)
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- Today, many people use the supplement including professionals and even average individuals who simply Formation Of Chlorogenic Acid Lactones want to suppress their appetite and lose weight The entire product is based on a natural formula This means you are not exposing your body to chemicals that may end up doing more damage. (triangleliteracy.org)
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Inhibition2
- Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. (nih.gov)
- Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. (abmole.com)
Researchers4
- In a mouse study by Korean researchers, extract of Urtica thunbergiana, which is rich with chlorogenic acid, was linked to better skin hydration. (nutraingredients-usa.com)
- Korean researchers studied skin health benefits of chlorogenic acid, an active component found in extract of the plant Urtica thunbergiana , which has been used medicinally in East Asia and is a common ingredient in soups and stews. (nutraingredients-usa.com)
- After researchers reviewed seven previously published studies, they concluded that chlorogenic acid causes a moderate reduction in systolic and diastolic blood pressure, reported the Journal of Human Hypertension in February 2015. (livestrong.com)
- The elusive search for pre-eclampsia prevention rumbles on as researchers find not even a high dose of folic acid is enough to ward off the condition in high-risk women. (nutraingredients-usa.com)
Supplements5
- To help me with this is been taking Chlorogenic Acid supplements. (dadamo.com)
- We'd take this a step further and envisage a future where chlorogenic acid is used in carbohydrate supplements for endurance athletes, calorie-rich post-workout products with fast sugars for strength athletes, and diet products for people who want to lose weight in an intelligent way. (ergo-log.com)
- Chlorogenic acid might be suitable for use in bodybuilding, slimming and endurance sports supplements, according to a study done at the National University of Singapore. (ergo-log.com)
- Choose supplements that contain one or more evidence-backed ingredients, such as caffeine plus chlorogenic acid, EGCG or capsaicin. (livestrong.com)
- In this study, both almond skin extract (AE) and chlorogenic acid (CHL) supplements, similar to traditional positive control resveratrol, significantly increased the replicative life-span of yeast compared to the untreated group. (preprints.org)
Inflammation2
- According to the pharmacopeia, chlorogenic acid is a common herbal extract with the functions of detoxification, anti-bacteria and anti-inflammation. (newleafherb.com)
- Studies have found chlorogenic acid reduces the risk of type II diabetes, lowers blood pressure and combats inflammation. (pe-factory.com)
Absorption2
- The net absorption (influent flux minus effluent flux of phenolic acids and their metabolites) accounted for 19.5 % and 8 % of the perfused caffeic and chlorogenic acids, respectively. (biomedsearch.com)
- Gastric absorption of feruloylquinic acid and di- O -caffeoylquinic acid analogs has never been investigated despite their potential contribution to the proposed beneficial health effects leading to reduced risk of type 2 diabetes. (aspetjournals.org)
Potent antioxidant2
- Chlorogenic acid has potent antioxidant and hepatoprotective activities. (ijpsonline.com)
- A potent antioxidant, chlorogenic a. (reference.com)