Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb. (1/22)The homeotic genes controlling segment identity in Drosophila are repressed by the Polycomb group of genes (PcG) and are activated by genes of the trithorax group (trxG). An F(1) screen for dominant enhancers of Polycomb yielded a point mutation in the heat shock cognate gene, hsc4, along with mutations corresponding to several known PcG loci. The new mutation is a more potent enhancer of Polycomb phenotypes than an apparent null allele of hsc4 is, although even the null allele occasionally displays homeotic phenotypes associated with the PcG. Previous biochemical results had suggested that HSC4 might interact with BRAHMA, a trxG member. Further analyses now show that there is no physical or genetic interaction between HSC4 and the Brahma complex. HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex. (+info)
Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes. (2/22)Vitamin C synthesis in rat liver is enhanced by several xenobiotics, including aminopyrine and chloretone. The effect of these agents has been linked to induction of enzymes potentially involved in the formation of glucuronate, a precursor of vitamin C. Using isolated rat hepatocytes as a model, we show that a series of agents (aminopyrine, antipyrine, chloretone, clotrimazole, metyrapone, proadifen, and barbital) induced in a few minutes an up to 15-fold increase in the formation of glucuronate, which was best observed in the presence of sorbinil, an inhibitor of glucuronate reductase. They also caused an approximately 2-fold decrease in the concentration of UDP-glucuronate but little if any change in the concentration of UDP-glucose. Depletion of UDP-glucuronate with resorcinol or d-galactosamine markedly decreased the formation of glucuronate both in the presence and in the absence of aminopyrine, confirming the precursor-product relationship between UDP-glucuronate and free glucuronate. Most of the agents did not induce the formation of detectable amounts of glucuronides, indicating that the formation of glucuronate is not due to a glucuronidation-deglucuronidation cycle. With the exception of barbital (which inhibits glucuronate reductase), all of the above mentioned agents also caused an increase in the concentration of ascorbic acid. They had little effect on glutathione concentration, and their effect on glucuronate and vitamin C formation was not mimicked by glutathione-depleting agents such as diamide and buthionine sulfoximine. It is concluded that the stimulation of vitamin C synthesis exerted by some xenobiotics is mediated through a rapid increase in the conversion of UDP-glucuronate to glucuronate, which does not apparently involve a glucuronidation-deglucuronidation cycle. (+info)
Epithelial activity of hexokinase and glucose-6-phosphate dehydrogenase in cultured bovine lenses recovering from pharmaceutical-induced optical damage. (3/22)PURPOSE: In a previous toxicological study, cultured bovine lenses exposed to three topical anesthetics displayed distinct patterns of optical damage and recovery. This work investigated the epithelial activity of the metabolic enzymes hexokinase (HK) and glucose-6-phosphate dehydrogenase (G6PD) in lenses recovering from anesthetic-induced damage. METHODS: Cultured bovine lenses were exposed to the anesthetics Alcaine, Fluress and Fluoracaine for 2 h. An automated laser scanner was used to determine the focal length variability (FLV) of the lenses at time-points up to 24 h following their return to fresh culture medium. The epithelial enzyme activities for HK and G6PD were then assayed at the 24 h time-point. RESULTS: Lenses exposed to Alcaine displayed an abrupt increase in FLV, while Fluoracaine treated lenses exhibited optical damage at a slower rate. The FLV in these two groups recovered to near-control levels after 24 h. Fluress treated lenses did not differ in FLV from controls at any time. The activities of both HK and G6PD were significantly reduced in epithelial samples from each of the three anesthetic treatment groups, relative to controls. CONCLUSIONS: These results show that lens optical quality can recover despite a severe reduction in epithelial HK and G6PD activity, indicating that the optical function of the lens may not be directly related to epithelial metabolic activity. The ScanTox In Vitro Assay System provides an objective measure of lens optical quality, enabling a direct comparison of optical damage and recovery to lens biochemical changes. (+info)
Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. (4/22)BACKGROUND AND PURPOSE: Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans. METHODS: We studied 5 consecutive patients with cerebral vasospasm who were treated with intra-arterial papaverine preserved with chlorobutanol and imaged with MRI fluid-attenuated inversion recovery and diffusion-weighted imaging after treatment. One patient had histological analysis of the brain at autopsy. RESULTS: All 5 patients exhibited marked neurological decline immediately after treatment, and this was sustained through hospital discharge. In all cases, MRI images showed selective gray matter-only signal changes within the vascular territory treated with papaverine. Histological analysis of 1 case brought to autopsy showed selective injury to islands of neurons with relative sparing of white matter. CONCLUSIONS: Intra-arterial delivery of papaverine preserved with chlorobutanol into vasospastic anterior cerebral arteries may result in marked neurological deterioration with selective gray matter changes on MRI imaging. This effect is consistent with a permanent toxic effect to human brain. It is unclear whether this toxicity is caused by papaverine or chlorobutanol, and its use in the treatment of cerebral vasospasm should be reserved for cases without alternatives. (+info)
Comparative toxicity of preservatives on immortalized corneal and conjunctival epithelial cells. (5/22)(+info)
GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture. (6/22)A gas chromatography with flame ionization detection method (GC-FID) with direct injection, using a capillary column, was validated to determine ethanol, acetaldehyde, methanol, and acetone in different human matrices, such as whole blood, vitreous humour, and urine, with clinical and forensic interest. This method was also employed to quantify these compounds in cell culture medium, thus being useful in basic research. A good peak resolution was achieved, with linear correlation between concentration and peak areas for all the compounds in all the matrices. The inter- and intra-day precisions of the method were always under 15% and 10%, respectively. The accuracy of the method, calculated as the percentage of the target concentration, was within the acceptable limits. The obtained limits of detection were below 0.85 mg/L for acetaldehyde and below 0.75 mg/L for the other considered compounds. The small injection volume and the high split ratios applied, allied to the high performance of the GC column, resulted in very good peak resolution and high sensitivities. This method is easy to perform, making it suitable for the routine of clinical biochemistry and forensic laboratories. (+info)
Interactions at human ether-a-go-go-related gene channels. (7/22)(+info)
A non-bronchoconstrictor, bacteriostatic preservative for nebuliser solutions. (8/22)We have studied the bacteriostatic and airways effects of the preservatives chlorocresol and chlorbutol, to assess if they may be safely used in nebuliser solutions. The bacteriostatic study was carried out according to standard techniques, and the preservatives were able to inhibit the growth of a range of bacteria and yeasts for a period of 28 days. The airways effects were studied in eight asthmatic subjects, who were challenged with either the preservatives or saline (as placebo). Pulmonary function was followed as FEV1 for 60 min after inhalation, and there was no change in FEV1 following inhalation. We conclude that these preservatives may be used safely in nebuliser solutions. (+info)
Chlorobutanol - Wikipedia
Chlorobutanol (trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations. However, it retains antimicrobial activity at 0.05% in water. Chlorobutanol has been used in anesthesia and euthanasia of invertebrates and fishes. It is a white, volatile solid with a menthol-like odor. ...
EFFECT OF ADDING CHLOROBUTANOL TO BISMUTH SUBSALICYLATE IN OIL INJECTED INTRAMUSCULARLY | JAMA Dermatology | JAMA Network
This study was undertaken to ascertain whether the addition of chlorobutanol to a suspension of bismuth subsalicylate in oil would produce any untoward effect w
Nayawax (Benzocaine; Chlorobutanol; P-Dichlorobenzene...) BMW Pharmaco India
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acidifying agents (examples include but are not limited to acetic acid, citric acid, fumaric acid, hydrochloric acid, nitric acid); alkalinizing agents (examples include but are not limited to ammonia solution, ammonium carbonate, diethanolamine, monoethanolamine, potassium hydroxide, sodium borate, sodium carbonate, sodium hydroxide, triethanolamine, trolamine); adsorbents (examples include but are not limited to powdered cellulose and activated charcoal); aerosol propellants (examples include but are not limited to carbon dioxide, CCl2F2, F2ClC-CClF2 and CClF3) air displacement agents (examples include but are not limited to nitrogen and argon); antifungal preservatives (examples include but are not limited to benzoic acid, butylparaben, ethylparaben, methylparaben, propylparaben, sodium benzoate); antimicrobial preservatives (examples include but are not limited to benzalkonium chloride, benzethonium chloride, benzyl alcohol, cetylpyridinium chloride, chlorobutanol, phenol, phenylethyl ...
111718 - Eficacia terapéutica del clorobutanol (Verruex®) en el tratamiento de papilomatosis bovina. Estudio en cuatro predios...
111718 - Eficacia terapéutica del clorobutanol (Verruex®) en el tratamiento de papilomatosis bovina. Estudio en cuatro predios en Caquetá, Colombia - Therapeutic efficacy of chlorobutanol (Verruex®) in the treatment of bovine papillomatosis. Study on | Veterinaria.org . La primera comunidad veterinaria de habla hispana con presencia en Espa a y Am rica del Sur.
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Effect of low levels of dietary tyrosine on the hair colour of cats<...
TY - JOUR. T1 - Effect of low levels of dietary tyrosine on the hair colour of cats. AU - Yu, S.. AU - Rogers, Quinton. AU - Morris, James. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Experiments were conducted to investigate the basis for the change in hair colour of black cats to reddish-brown. Black cats were given purified diets based on gelatin, casein plus lactalbumin, or crystalline amino acids as protein sources. Diets that caused the colour of hair to change to reddish-brown were associated with a reduction in melanin in hair (observed by direct microscopic examination), a decreased total melanin concentration and low concentrations of tyrosine in plasma. Reddish hair coat was induced in black kittens born to queens given a tyrosine-deficient diet during pregnancy. Black hair colour was maintained or restored by diets containing a high concentration of tyrosine or phenylalanine. Current dietary recommendations for dietary tyrosine and phenylalanine for cats are below those required to support ...
Stability study of azithromycin in ophthalmic preparations
MORENO, Andréia de Haro; SILVA, Maria Fernanda Conz da and SALGADO, Hérida Regina Nunes. Stability study of azithromycin in ophthalmic preparations. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.2, pp.219-226. ISSN 2175-9790. http://dx.doi.org/10.1590/S1984-82502009000200005.. A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 µg/mL. The study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).. Keywords : Azithromycin [stability study]; Bioassay; Photodegradation; Ophthalmic preparations. ...
Examination of postoperative pain management programs indicates that nearly 100% of patients are treated with opioids; of these patients, 15% experience opioid-related adverse events (Kessler et al., 2013). More concerning is that although opioids are becoming less common, they continue to be prescribed for outpatient management of chronic pain, a setting that is less likely to be extensively monitored and represents a higher risk for mortality (Labianca et al., 2012). Obesity, a condition closely linked with NAFLD (McCullough, 2011), is one identified risk factor for these toxicities. NASH, the later stage of NAFLD, is characterized not only by histopathologic consequences but also by alterations in the expression and function of vital phase I and II drug metabolizing enzymes and transport proteins (Fisher et al., 2009; Hardwick et al., 2010, 2013; Lake et al., 2011). Previous studies have confirmed corresponding shifts in the disposition of certain xenobiotics in rodent models of NASH (Canet ...
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Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. Doxapram is a white to off-white, odorless, crystalline powder that is stable in light and air. It is soluble in water, sparingly soluble in alcohol and practically insoluble in ether. Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially available injections. Doxapram is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as buprenorphine or fentanyl analogues which may fail to respond adequately to treatment with naloxone. It ...
The effect of dietary crude protein level, formaldehyde treated rapeseed (Canola) meal and dietary tyrosine supplementation on...
The effect of dietary crude protein level, formaldehyde treated rapeseed (Canola) meal and dietary tyrosine supplementation on the performance of lactating dairy ...
The human CYP1A1 gene codes for an inducible enzyme system involved in biotransformation of certain xenobiotics, including polycyclic aromatic hydrocarbons; some of the metabolites are carcinogenic and mutagenic. Effects of environmental exposures (smoking, air pollution, and diet) on CYP1A1 gene induction in placental tissue and the modulation of induction by the CYP1A1 MspI RFLP were evaluated in two groups from Poland: 70 mother-child pairs from Krakow, a city with elevated air pollution; and 90 pairs from Limanowa, a less polluted area. Compared to placentas from nonsmoking women, CYP1A1 mRNA levels were significantly increased in placentas from current smokers (P , 0.001). Ex-smokers also had significantly higher placental mRNA levels, including women who quit smoking prior to pregnancy (P , 0.01). A marginal increase in CYP1A1 mRNA with environmental tobacco smoke exposure was evident. Within Krakow, there was an increase in CYP1A1 mRNA with ambient pollution at the place of residence for ...
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Samson, A. L., Nevin, S. T. and Medcalf, R. L. (2008) Low molecular weight contaminants in commercial preparations of plasmin and t-PA activate neurons. Journal of Thrombosis and Haemostasis, 6 12: 2218-2220. doi:10.1111/j.1538-7836.2008.03174.x ...
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SUSER_ID returns an identification number only for logins that have been explicitly provisioned inside SQL Server. This ID is used within SQL Server to track ownership and permissions. This ID is not equivalent to the SID of the login that is returned by SUSER_SID. If login is a SQL Server login, the SID maps to a GUID. If login is a Windows login or Windows group, the SID maps to a Windows security identifier.. SUSER_SID returns a SUID only for a login that has an entry in the syslogins system table.. System functions can be used in the select list, in the WHERE clause, and anywhere an expression is allowed, and must always be followed by parentheses, even if no parameter is specified.. In SQL Server version 7.0, the security identification number (SID) replaced the server user identification number (SUID).. ...
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6.5 Nature and Contents Of Container. A sealed conical shaped container fitted with a twist and pull off cap made from Ph. Eur. grade polypropylene for containers and closures for parenteral and ophthalmic preparations. Each Minims unit is overwrapped in an individual polypropylene/paper pouch. Each container holds approximately 0.5ml of solution. There are 20 Minims units in every carton ...
The Effects of Commercial Preparations of Herbal Supplements Commonly Used by Women on the Biotransformation of Fluorogenic...
The Effects of Commercial Preparations of Herbal Supplements Commonly Used by Women on the Biotransformation of Fluorogenic Substrates by Human Cytochromes P450 Academic Article ...
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A Pharmacists Guide to OTC Therapy: Ophthalmic Preparations for Treating Allergic Conjunctivitis
Decongestants Available ophthalmic decongestants include phenylephrine, naphazoline, oxymetazoline, and tetrahydrolozine. Individuals should be informed that overuse of ophthalmic decongestants can lead to rebound congestion of the conjunctiva. Patients with narrow anterior chamber angles or narrow-angle glaucoma should not use these products.1 Antihistamines Pheniramine maleate is the antihistamine agent available in nonprescription ophthalmic preparations. The most common adverse reactions associated with its use include stinging, burning, and discomfort upon instillation. Role of the Pharmacist Prior to suggesting any OTC ophthalmic products, pharmacists should thoroughly assess the nature and extent of patients ophthalmic problems and recommend that they seek medical care when needed. Patients also should be advised not to exceed the recommended dosages of these products and to immediately seek medical attention if symptoms persist after a few days. Although adverse effects are considered ...
Apitherapy News: February 2016
Precursors of neuroactive substances can be obtained from dietary sources, which can affect the resulting production of such substances in the brain. In social species, an intake of the precursor in food could be controlled by social interactions. To test the effects of dietary tyrosine on the brain dopamine levels in social insect colonies, male and worker honeybees were fed tyrosine or royal jelly under experimental conditions and the brain levels of dopamine and its metabolite were then measured. The results showed that the levels of dopamine and its metabolite in the brains of 4- and 8-day-old workers and 8-day-old males were significantly higher in tyrosine-fed bees than in control bees, but the levels in 4-day-old males were not. The brain levels of dopamine and its metabolite in 4- and 8-day-old males and workers were significantly higher in royal jelly-fed bees than in control bees, except for one group of 4-day-old workers. Food exchanges with workers were observed in males during 1-3 ...
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Development of a topical tissue cross-linking solution using sodium hydroxymethylglycinate (SMG): viscosity effect | Bioscience...
Viscosity is a critical component of ophthalmic preparations. There have been many viscosity enhancing agents used for drug delivery, but HPMC stands out quite clearly as being extremely efficacious and pliable [20-23]. There are various HPMC grades, and the grade and viscosity of HPMC are dependent on the differences in molecular weight (chain length) and the extent of hydroxypropyl and methyl substitutions . We could possibly manipulate two properties of HPMCs viscosity: concentration and grade. In a study of isoniazid (MW ∼137 Da) release from HPMC tablets , it was found that higher viscosity grades of HPMC decreased the rate of drug release from the tablet. They theorized this is due to the intra-polymer matrix interactions, particularly the disentanglement of polymer chains, which prevent effective drug release. These drug-polymer matrix interactions become greater with more branching present in higher grades of HPMC. Our expectation was that the higher HPMC grades, accompanied ...
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Hydrocortisone acetate exerts a marked anti-inflammatory action at the tissue level and effectively suppresses inflammation in many disorders of the anterior segment of the eye. Local application to the eye often gives rapid relief of pain and photophobia, particularly in lesions of the cornea.. The combined anti-inflammatory and antimicrobial activity of Bacitracin-Neomycin-Polymyxin-Hydrocortisone Acetate 1% Veterinary Ophthalmic Ointment permits effective management of many disorders of the anterior segment of the eye in which combined activity is needed.. Doasage & Administration: Apply a thin film over the cornea three or four times daily in dogs and cats. The area should be properly cleansed prior to the use of bacitracin-neomycin-polymyxin-HC veterinary ophthalmic ointment. Foreign bodies, crusted exudates, and debris should be carefully removed. Contraindications: Ophthalmic preparations containing corticosteroids are contraindicated in the treatment of those deep, ulcerative lesions of ...
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damaged - David Bradley
Electronic devices are susceptible to damage from radiation, potentially cosmic radiation and even ultraviolet radiation. A study using spectroscopy reveals that the amount of optical damage, as opposed to structural damage, that can be caused may be more than ten times greater than studies suggested.. These are somewhat new ideas, especially in my opinion the concept of optical damage versus structural damage where as people normally focus on the later, I believe the former is a very much unexplored area with important implications for actual, real, operating nanodevices, research leader Andrew Steigerwald of Vanderbilt University told me.. Considering that, I hope in the future that our results can be extended to other materials (e.g. silicon) and perhaps coupled with a sensitive microscopy technique so that we can compare spectroscopy results with mapping of electronic states.. Damaged goods: Probing the depths - Ezine - spectroscopyNOW.com.. ...
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Combination therapy using nebulized amiloride hydrochloride and uridine-5-triphosphate (UTP) trisodium salt aerosols has been investigated for the treatment of cystic fibrosis (CF). Amiloride in aqueous solution precipitates in the presence of UTP, reducing drug concentrations. Interactions between these drugs and NaCl in solution were studied using phase-solubility techniques monitored by UV spectrophotometry. Elemental analyses were employed for precipitate characterization. Amiloride solubility was reduced by more than 85% in saline.
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or [email protected] -----Original Message----- From: HSRL [mailto:[email protected]] Sent: Thursday, July 10, 2003 8:49 AM To: [email protected] Subject: Controls for human spleen liver placenta Does anyone have a good supplier of human tissue or prepared slides. We are mainly interested in spleen, liver and placenta. Thanks in advance for your help. Beth Poole HSRL- A GLP Compliant Laboratory 137 South Main Street Woodstock, Virginia 22664 (540)459-8211 Fax: (540)459-8217 [email protected] www.hsrl.org ...
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Satoh T, Sakurai E, Tada H & Masuda T. (2009). Ontogeny of reticular framework of white pulp and marginal zone in human spleen: immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation. Cell Tissue Res. , 336, 287-97. PMID: 19255788 DOI. ...
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Quest for photo-stable amorphous thin films in ternary GexAsySe100-x-y chalcogenide system is reported. Studied layers were fabricated using pulsed laser deposition technique. Scanning electron microscope with energy dispersive X-ray analyzer, Raman scattering spectroscopy, transmittance measurements, variable angle spectroscopic ellipsometry, and non-linear imaging technique with phase object inside the 4f imaging system were employed to characterize prepared thin films. Their photo-stability/photo-induced phenomena in as-deposited and relaxed states were also investigated, respectively. In linear regime, we found intrinsically photo-stable relaxed layers within Ge20As20Se60 composition. This composition presents also the highest optical damage threshold under non-linear optical conditions.. ©2010 Optical Society of America. Full Article , PDF Article ...
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Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma - Full...
OUTLINE: This is a dose-escalation study of trimetrexate glucuronate.. Patients receive high-dose methotrexate IV over 4 hours on days 1 and 8 and oral trimetrexate glucuronate twice daily on days 2-6 and 9-13. Patients also receive leucovorin calcium IV continuously over 24 hours or orally 2 or 4 times daily on days 9-14. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.. Cohorts of 3-6 patients receive escalating doses of trimetrexate glucuronate until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.. PROJECTED ACCRUAL: A maximum of 18 patients will be accrued for this study within 2 years. ...
OSA | Investigation of damage mechanisms of KTiOPO4 crystals by use of a continuous-wave argon laser
We have developed a simple method that uses cw irradiation from an argon laser to measure the damage threshold of KTP crystals. Our experimental results show that there are two types of damage in KTP crystal, depending on the polarization of the incident laser beam. One type of optical damage is the appearance of gray tracks, including both dark tracks and orange dots, when the pump polarization is perpendicular to the z axis. The other type is invisible damage when the polarization is parallel to the z axis. In addition, we have also observed weak photorefractive two-wave mixing in KTP crystals in each of these polarization states. After a systematic analysis we have concluded that the first type of damage is due to the formation and absorption of Ti3+ and Fe3+ centers and the second is due to the drift of K+ ions. The weak photorefractive effect is the result of screening of the electric field by the drifted K+ ions.. © 2000 Optical Society of America. Full Article , PDF Article ...
A rare case of giant verruciform xanthoma in the palate
ROSA, Eduardo Augusto and AMORIM, Rivadávio Fernandes Batista de. A rare case of giant verruciform xanthoma in the palate. RGO, Rev. Gaúch. Odontol. [online]. 2014, vol.62, n.1, pp.77-81. ISSN 1981-8637. https://doi.org/10.1590/1981-86372014000100000122081.. Verruciform xanthoma represents a rare disease of unknown etiology that typically affects the oral mucosa. In most cases, it is asymptomatic and characterized by a well demarcated elevation with irregular or papillary surface. The gums are the most affected oral site, and the lesion is usually less than 2 cm in diameter. The aim of this study is to report a rare case of an extensive verruciform xanthoma in the hard palate and gums of a 55-year-old male. Clinically, the well delimitated, reddish, elastic lesion measuring approximately 2.8 X 1.5 cm had a slightly granular surface. Histopathological analysis found proliferative epithelial activity with evident papillomatosis, parakeratosis, and large epithelial ridges. Xanthomatous cells with ...
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Preservatives are chemicals added to pharmaceutical, hygiene and food products to prevent and delay their decomposition. Fruit preservatives are commonly used in juices, jellies, canned fruit and dried fruit.
Hyper Kids? Cut Out Preservatives - TIME
A new British study finds the clearest evidence yet that common food colorings and preservatives can trigger hyperactivity in normal children
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The global market size of Organic Solvent Preservatives is $XX million in 2017 with XX CAGR from 2013 to 2017, and it is expected to reach $XX million by the end of 2023 with a CAGR of XX% from 2018 to 2023 ...
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... is highly toxic to the liver, is a skin irritant and a severe eye irritant. Chlorobutanol has proven effective at ... Chlorobutanol was first synthesized in 1881 by the German chemist Conrad Willgerodt (1841-1930). Chlorobutanol is formed by the ... Chlorobutanol has been used in anesthesia and euthanasia of invertebrates and fishes. It is a white, volatile solid with a ... Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations ...
Chlorobutanol Disulfiram-like drug Trichloroethanol Notes Vardanyan, R.S.; Hruby, V.J. (2006). "Soporific Agents (Hypnotics and ...
Alongside the Willgerodt reaction, he had also discovered Iodosobenzene and chlorobutanol. As for his career, Conrad Willgerodt ...
Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially ...
Brødbaek HB, Damkier P (May 2007). "[The treatment of hyperemesis gravidarum with chlorobutanol-caffeine rectal suppositories ... and of chlorobutanol and caffeine (for the treatment of hyperemesis). However, rectal absorption is less efficient than oral: ...
Preservatives include benzalkonium chloride (BAK), ethylenediaminetetraacetic acid (EDTA), purite, chlorobutanol, sodium ...
... and of chlorobutanol. Historically, it has been used as a sedative hypnotic. The hypnotic drug triclofos (2,2,2-trichloroethyl ...
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Nasal medications containing diluted hydrochloric acid, chlorobutanol, and benzyl alcohol have been reported to be effective in ...
Medicine portal Aroma compound Carvone Chlorobutanol Ethyl benzoate Ethyl salicylate Menthoxypropanediol Methyl salicylate ...
List of drugs: Cf-Ch
... chlorobutanol (INN) chlorocresol (INN) Chlorofair Chlorofon-A Tablet Chloromag Chloromycetin Chloromyxin chloroprednisone (INN ...
Dimenhydrinate Diphenhydramine Doxylamine Hydroxyzine Promethazine General anaesthetics Chloral hydrate Chlorobutanol ...
ATC code A04
... combinations A04AD54 Chlorobutanol, combinations QA04AD90 Maropitant "ATC (Anatomical Therapeutic Chemical Classification ... combinations A04AD01 Scopolamine A04AD02 Cerium oxalate A04AD04 Chlorobutanol A04AD05 Metopimazine A04AD10 Dronabinol A04AD11 ...
List of MeSH codes (D02)
... chlorobutanol MeSH D02.033.415.110.855 - tert-butyl alcohol MeSH D02.033.415.220 - dodecanol MeSH D02.033.415.220.720 - sodium ... chlorobutanol MeSH D02.033.260.335 - ethchlorvynol MeSH D02.033.260.350 - ethylene chlorohydrin MeSH D02.033.375.270 - ...
List of MeSH codes (D10)
... chlorobutanol MeSH D10.289.110.855 - tert-butyl alcohol MeSH D10.289.220.720 - sodium dodecyl sulfate MeSH D10.289.230.250 - ...
Sciencemadness Discussion Board - Chlorobutanol synthesis - Powered by XMB 1.9.11
Chlorobutanol synthesis. A while ago i stumbled across a fairly easy looking synthesis for a chemical known as chlorobutanol. ... the re-crystallized chlorobutanol with a razor blade or other sharp straight. edge. Store the chlorobutanol in a closed dark ... Chlorobutanol: Cl3CC(CH3)2OH: Colorless to white crystals with characteristic odor and taste. Soluble in alcohol and glycerol; ... Storing Chloretone, chlorobutanol.. STABILITY: the half-life at 25 for chlorobutol(chloretone) in a solution buffered at pH 3 ...
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As one of the China Chlorobutanol CAS 57-15-8 manufacturers and suppliers, we can provide customers with high quality products ... Buy Chlorobutanol CAS 57-15-8 made in China from our factory. ... Chlorobutanol CAS 57-15-8. We are a leading manufacturer of ... Chlorobutanol CAS 57-15-8 is available in stock and can be delivered quickly. COA, MSDS and TDS of Chlorobutanol CAS 57-15-8. ... Chlorobutanol CAS 57-15-8 Chemical Properties Melting point ~78 ° C. Boiling point 173 ° C. Density 1.3170 (estimate). Flash ...
Browsing Faculté de Médecine by Subject "Antimicrobial agent, bacterial and fungal strains, chlorobutanol, MIC."
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US9320712B2 - Dexmedetomidine premix formulation - Google Patents
Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989-2014 - Volume 22, Number 6-June 2016 - Emerging...
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Chlorobutanol anhydrous (chloral derivative) added as a preservative may be habit forming. ... 5 mg/mL-5 mg estradiol cypionate, 5.4 mg chlorobutanol anhydrous (chloral derivative) added as preservative; in... ... 5 mg estradiol cypionate; also 5.4 mg chlorobutanol anhydrous (chloral deriv.) added as... ...
Featured Excipient: Plasticizers
Chlorobutanol NF, Diacetylated Monoglycerides NF, Dibutyl Sebacate NF, Diethyl Phthalate NF, Glycerin USP, mineral oil and ... Chlorobutanol NF, Diacetylated Monoglycerides NF, Dibutyl Sebacate NF, Diethyl Phthalate NF, Glycerin USP, mineral oil and ... Chlorobutanol, NF, as plasticizer, Diacetylated monoglycerides, NF, as plasticizer, Dibutyl sebacate, NF, as plasticizer, ...
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Methaqualone - Wikipedia
Methaqualone became increasingly popular as a recreational drug in the late 1960s and 1970s, known variously as "ludes" or "sopers" (also "soaps") in the United States and "mandrakes" and "mandies" in the UK, Australia and New Zealand. Sopor is a Latin word for sleep. The drug was more tightly regulated in Britain under the Misuse of Drugs Act 1971 and in the U.S. from 1973. It was withdrawn from many developed markets in the early 1980s. In the United States it was withdrawn in 1983 and made a Schedule I drug in 1984. It has a DEA ACSCN of 2565 and in 2022 the aggregate annual manufacturing quota for the United States was 60 grams. Mention of its possible use in some types of cancer and AIDS treatments has periodically appeared in the literature since the late 1980s. Research does not appear to have reached an advanced stage. The DEA has also added the methaqualone analogue mecloqualone (also a result of some incomplete clandestine syntheses) to Schedule I as ACSCN 2572, with a ...
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Indian Patents. 212551:'ANHYDROUS, HYDROPHILIC ABSORBENT WOUND DRESSING (TUBE) WITH ANTIMICROBIALS OR OTHER PHARMACEUTICALLY...
Chlorobutanol 0.6. Example 7. Ingredient % w/w. Poloxamer 407 14.0. Poloxamer 338 5.5. Poloxamer 124 34.25. Propylene Glycol ... Chlorobutanol 0.6. Example 4. Ingredient % w/w. Polyethylene Glycol 400 64.25. Polyethylene Glycol 3350 - 23.0. Acrylamide/ ... Chlorobutanol, Cloflucarban, Dapsone, Dehydroacetic Acid or salt form thereof, Ethyl Alcohol, Eucalyptol, Extracts of Lavender ...
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- Chlorobutanol anhydrous (chloral derivative) added as a preservative may be habit forming. (pfizermedicalinformation.com)
- According to the Statement of Non-Compliance issued in EudraGMDP this statement is valid for all APIs: "The Plant I produced Metoprolol Tartrate, Metoprolol Succinate, Chlorobutanol Hemihydrate, Chlorobutanol Anhydrous and Fluconazole. (gmp-compliance.org)
- Other ingredients include chlorobutanol hemihydrate, acetic acid glacial and water for injections. (who.int)
- All CEPs have been suspended: CEP 2009-112 (Chlorobutanol hemihydrate), CEP 2009-152 (Metoprolol tartarate), CEP 2009-170 (Metoprolol Succinate), CEP 2010-147 (Ferrous fumarate), CEP 2010-247 (Fluconazole), CEP 2011-304 (Metoprolol tartarate), CEP 2011-312 (Metoprolol Succinate). (gmp-compliance.org)
- Each gram of sterile ophthalmic ointment contains tobramycin 3 mg and dexamethasone 0.1% with chlorobutanol 0.5% as a preservative in a mineral oil and petrolatum base. (pharmachoice.com)
- 200 mg testosterone enanthate in sesame oil with 5 mg chlorobutanol (chloral. (enrique-calderon.com)
- Each ml of sterile, colorless to pale yellow solution provides 200 mg testosterone enanthate in sesame oil with 5 mg chlorobutanol (chloral derivative) as a. (blvcklxtus.com)
- antibacterial Chlorhexidine digluconate (0.1%) and Chlorobutanol (0.5%) helps maintain good oral hygiene. (pharmanatura.gr)
- Pitocin is composed of oxtocic acid/ml along with chlorobutanol , a chloroform derivative. (pharmawiki.in)
- Believe Chemical is a leading China Chlorobutanol CAS 57-15-8 manufacturer, supplier and exporter. (believechemical.com)
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- Browsing Faculté de Médecine by Subject "Antimicrobial agent, bacterial and fungal strains, chlorobutanol, MIC. (ummto.dz)
- A while ago i stumbled across a fairly easy looking synthesis for a chemical known as chlorobutanol. (sciencemadness.org)
- Anyways after sorting out the fragmented directions at http://www.rhodium.ws/chemistry/chlorobutanol.txt i figured that all i needed was generic bleach, acetone, lye, denatured alcohol and a bit of equipment. (sciencemadness.org)
- Adhering to the pursuit of perfect quality of products, so that our Chlorobutanol CAS 57-15-8 have been satisfied by many customers. (believechemical.com)
- Benzalkonium chloride (BAK), chlorobutanol, chlorhexidine acetate (CHA), and phenylmercuric nitrate or acetate are some commonly used preservatives in eye preparations. (filonanotech.com)
- Each gram of Tobrex ophthalmic ointment 0.3% contains tobramycin 0.3% (3 mg), chlorobutanol 0.5%, mineral oil, white petrolatum. (healthwiregeorgia.com)
- Inactive Ingredients: Chlorobutanol (0.5%), Lanolin Alcohols. (universitypharmacy.ca)
- Chlorobutanol  and 2-phenylethanol  are adversely affected by the presence of non-ionic surfactants, e.g. polysorbate 80. (chemistscorner.com)
- chlorobutanol and sesame oil. (rxhealthmed.ca)
- After the addition of chlorobutanol, the suicide effect of the drug preparation was significantly enhanced. (medical-steroids.com)
- 4-Chlorobutanol = 4 reactions were found. (tu-bs.de)
- Although the antimicrobial activity of chlorobutanol is extensive, [ 18 ] its use has been limited due to the fact that it becomes unstable when stored at room temperature for extended periods of time. (medscape.com)
- [ 16 ] Human corneal epithelial cells exposed to chlorobutanol display a decreased amount of mitoses and deterioration of overall cell integrity. (medscape.com)
- The lethal human chlorobutanol dose is recovered in the past 1-6 weeks. (childbirthsolutions.com)
- Chlorobutanol is highly toxic to the liver, is a skin irritant and a severe eye irritant. (psychonautwiki.org)
- [ 17 ] The method of action of chlorobutanol is cell lysis by way of disruption of microbial cell membrane lipid configuration. (medscape.com)