A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
A benzodiazepine derivative used as an anticonvulsant and hypnotic.

Hypnotics and hangovers: a pilot study of chlormezanone in general practice. (1/3)

Ten patients were included in this pilot study of chlormezanone, assessing its effects on duration and quantity of sleep and daytime performance using a pursuit rotor and a digit symbol test. Comparisons of the sleep assessments favoured chlormezanone, although the differences were not statistically significant. There was no evidence of any reduction in daytime performance after chlormezanone. The comparison of chlormezanone and placebo on the pursuit rotor test and the visual analogue assessment of hangover both slightly favoured the drug, but there were no significant differences. The study has demonstrated that it is feasible to evaluate hypnotic drugs more exactly in general practice.  (+info)

A comparison of the effects of chlormezanone and nitrazepam on sleep. (2/3)

1 Twelve volunteers, of mean age 60 years, took part in a double-blind, balanced cross-over study, to compare effects of chlormezanone 400 mg and nitrazepam 5 mg on electrophysiologically-recorded and subjectively-rated sleep. 2 In the first week of administration nitrazepam caused a significant shortening of the time to fall asleep, but following withdrawal subjects took longer to fall asleep than during the baseline period. 3 Both chlormezanone and nitrazepam initially caused increase of sleep duration and less interruption of sleep by wakefulness. By the third week, for chlormezanone this effect was no longer significant, and for nitrazepam there was a significant decline in the effect. There was no statistically significant difference between the two drugs for these measures. 4 The drugs differed little in their effects on the amount of the various sleep stages, except that nitrazepam significantly reduced the duration of slow wave sleep, whereas chlormezanone had no significant effect on slow wave sleep. Both drugs reduced the amount of REM sleep in the first 6 h of sleep but only nitrazepam reduced the percentage of the time spent in REM sleep of the whole night. 5 Subjects' own ratings of sleep quality showed that both of the drugs improved sleep, but following withdrawal it was only after nitrazepam that there was impairment of the quality of sleep. Neither drug affected subjective alertness in the morning.  (+info)

Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. (3/3)

BACKGROUND: Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare, life-threatening, drug-induced cutaneous reactions. We conducted a case-control study to quantify the risks associated with the use of specific drugs. METHODS: Data were obtained through surveillance networks in France, Germany, Italy, and Portugal. Drug use before the onset of disease was compared in 245 people who were hospitalized because of toxic epidermal necrolysis or Stevens-Johnson syndrome and 1147 patients hospitalized for other reasons (controls). Crude relative risks were calculated and adjusted for confounding by multivariate methods when numbers were large enough. RESULTS: Among drugs usually used for short periods, the risks were increased for trimethoprim-sulfamethoxazole and other sulfonamide antibiotics (crude relative risk, 172; 95 percent confidence interval, 75 to 396), chlormezanone (crude relative risk, 62; 21 to 188), aminopenicillins (multivariate relative risk, 6.7; 2.5 to 18), quinolones (multivariate relative risk, 10; 2.6 to 38), and cephalosporins (multivariate relative risk, 14; 3.2 to 59). For acetaminophen, the multivariate relative risk was 0.6 (95 percent confidence interval, 0.2 to 1.3) in France but 9.3 (3.9 to 22) in the other countries. Among drugs usually used for months or years, the increased risk was confined largely to the first two months of treatment, when crude relative risks were as follows: carbamazepine, 90 (95 percent confidence interval, 19 to infinity); phenobarbital, 45 (19 to 108); phenytoin, 53 (11 to infinity); valproic acid, 25 (4.3 to infinity); oxicam nonsteroidal antiinflammatory drugs (NSAIDs), 72 (25 to 209); allopurinol, 52 (16 to 167); and corticosteroids, 54 (23 to 124). For many drugs, including thiazide diuretics and oral hypoglycemic agents, there was no significant increase in risk. CONCLUSIONS: The use of antibacterial sulfonamides, anticonvulsant agents, oxicam NSAIDs, allopurinol, chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. But for none of the drugs does the excess risk exceed five cases per million users per week.  (+info)

Chlormezanone is a benzodiazepine-like tranquilizer, which is primarily used for the treatment of moderate to severe anxiety and insomnia. It works by depressing the central nervous system, producing a calming effect on the brain. Chlorazenone has sedative, muscle relaxant, and anticonvulsant properties.

It's important to note that chlormezanone is not commonly used in clinical practice due to its potential for serious side effects, including liver toxicity, and because other benzodiazepines or related drugs are generally preferred for their safer profile and greater efficacy. As with any medication, it should only be taken under the supervision of a healthcare provider, and its use may be subject to certain restrictions in some countries.

Nitrazepam is a benzodiazepine drug primarily used for the treatment of severe insomnia and sometimes for managing certain types of epilepsy. It works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits central nervous system activity, thereby producing calming effects.

According to the World Health Organization's (WHO) Anatomical Therapeutic Chemical (ATC) classification system, Nitrazepam falls under the category of "N05CD - Benzodiazepine derivatives" and has the ATC code "N05CD02".

It is essential to note that Nitrazepam should only be used under medical supervision due to its potential for dependence, addiction, and other side effects. It is also not recommended for long-term use or in pregnant or breastfeeding women without consulting a healthcare professional first.

... (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant. Its ... Wollina U, Hipler UC, Seeling A, Oelschlager H (2005). "Investigations of interactions of chlormezanone racemate and its ... Gautier V, Vinçon G, Demotes-Mainard F, Albin H (1990). "[Pharmacokinetics of chlormezanone in healthy volunteers]". Therapie. ... September 1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Die Pharmazie. 53 (9): 620- ...
"E-DRUG: Chlormezanone". Essentialdrugs.org. Archived from the original on 26 July 2011. "Loperamide: a medicine used to treat ...
Adam K, Oswald I (July 1982). "A comparison of the effects of chlormezanone and nitrazepam on sleep". British Journal of ...
... chlormezanone (INN) chlormidazole (INN) chlornaphazine (INN) chlorobutanol (INN) chlorocresol (INN) Chlorofair Chlorofon-A ...
... chlormezanone MeSH D03.383.855.400 - nifurtimox MeSH D03.383.855.500 - piroxicam MeSH D03.383.855.785 - thiadiazines MeSH ...
2-trichloroethanol prodrugs Chlormezanone Clomethiazole Dihydroergolines (e.g., ergoloid (dihydroergotoxine)) Etazepine ...
... chlormezanone) anticonvulsants (phenobarbital, phenytoin, carbamazepine, lamotrigine, and valproic acid). TEN has also been ...
... and chlormezanone. Allopurinol appears in some studies to be the most common instigator of these disorders. Any new biological ...
... chlormezanone MeSH D02.886.665.400 - nifurtimox MeSH D02.886.665.500 - piroxicam MeSH D02.886.665.785 - thiadiazines MeSH ...
... combinations with psycholeptics QM03BA99 Combinations M03BB02 Chlormezanone M03BB03 Chlorzoxazone M03BB52 Chlormezanone, ... combinations excluding psycholeptics M03BB53 Chlorzoxazone, combinations excluding psycholeptics M03BB72 Chlormezanone, ...
Chlormezanone (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant. Its ... Wollina U, Hipler UC, Seeling A, Oelschlager H (2005). "Investigations of interactions of chlormezanone racemate and its ... Gautier V, Vinçon G, Demotes-Mainard F, Albin H (1990). "[Pharmacokinetics of chlormezanone in healthy volunteers]". Therapie. ... September 1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Die Pharmazie. 53 (9): 620- ...
... muscle spasm caused by five common musculoskeletal diseases were included in a double-blind controlled trial of chlormezanone, ... The relief of muscle spasm and pain with chlormezanone and chlormezanone with aspirin: a blind, crossover study. Woolsey RM, ... Fifty-three per cent improved on placebo, 57 percent on chlormezanone, 66 percent on orphenadrine and 71 percent on ... There was no significant difference between chlormezanone and placebo, but orphenadrine appeared to have a beneficial effect, ...
Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous pustulosis, ...
Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous pustulosis, ...
Chlormezanone. en. dc.subject.mesh. Substance Abuse Detection. en. dc.subject.mesh. Terfenadine. en. ...
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
... chlormezanone,chlormethazanone,128,1,r,1, chlormezanone,Trancopal,128,1,r,1, chlorosis,asiderotic anaemia,128,1,r,1, chlorosis, ...
CHLORMEZANONE CHLOROQUINE (*) CIBENZOLINE CICLETANINE CIPROFIBRATE CLiNDAMYCINE CLOBAZAM CLOFIBRATE CLOMETHIAZOLE CLOMIFENE ...
CHLORMEZANONE. CHLOROBUTANOL. CHLOROQUINE AND ITS SALTS. CHLOROTHIAZIDE, ITS SALTS. AND DERIVATES. (C) CHLORPHENTERMINE AND. ...
Chlormezanone,N0000006870, Zinc,N0000006869, Sulfadiazine,N0000006868, diisopropanolamine,N0000006867, Linoleic Acid, ...
Drug-induced hepatitis with cholestasis following therapy with chlormezanone]. Pomiersky C, Blaich E. Pomiersky C, et al. Z ...
Miscellaneous individual drugs (eg, allopurinol, chlormezanone). Cases that are not caused by drugs are attributed to ...
CHLORMEZANONE 51068 CHLOROACETIC ACID 51070 CHLOROALLYHEXAMINIUM CHLORIDE 51075 CHLOROBUTANOL 51080 CHLOROFORM 51085 ...
Chlormezanone. Fixed drug eruption has been reported in 2 patients receiving saquinavir, an HIV-1 protease inhibitor. ...
Product containing chlormezanone (medicinal product). Code System Preferred Concept Name. Product containing chlormezanone ( ... Product containing chlormezanone (medicinal product) {71634000 , SNOMED-CT } Parent/Child (Relationship Type) Product ... containing chlormezanone and paracetamol (medicinal product) {398794008 , SNOMED-CT } Product containing only chlormezanone ( ...
Chlormezanone Preferred Term Term UI T007887. Date01/01/1999. LexicalTag NON. ThesaurusID ... Chlormezanone Preferred Concept UI. M0004158. Registry Number. GP568V9G19. Related Numbers. 80-77-3. Scope Note. A non- ... Chlormezanone. Tree Number(s). D02.886.665.150. D03.383.855.150. Unique ID. D002720. RDF Unique Identifier. http://id.nlm.nih. ...
Chlormezanone Preferred Term Term UI T007887. Date01/01/1999. LexicalTag NON. ThesaurusID ... Chlormezanone Preferred Concept UI. M0004158. Registry Number. GP568V9G19. Related Numbers. 80-77-3. Scope Note. A non- ... Chlormezanone. Tree Number(s). D02.886.665.150. D03.383.855.150. Unique ID. D002720. RDF Unique Identifier. http://id.nlm.nih. ...
TRANCOSIL TABLETS 200MG (CHLORMEZANONE) EVEREST. 肌肉、骨骼系統 肌肉鬆弛劑 成分劑量. Chlormezanone……200mg ...
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
Chlormezanone. Cholestyramine Resin. Choline Theophyllinate. Chondroitin and its salts3. Chromic Chloride. Chymopapain. ...
Chlormezanone. Fixed drug eruption has been reported in 2 patients receiving saquinavir, an HIV-1 protease inhibitor. ...
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
... chlormezanone, E0005923,Uniphylline,theophylline, E0005972,Urecholine,bethanechol chloride, E0005976,Uval,sulisobenzone, ...
chlormezanone. Infectious. Viral. Herpes simplex virus Simplex Virus A genus of the family herpesviridae, subfamily ...
... chlormezanone,chlormethazanone,128,1,r,1, chlormezanone,Trancopal,128,1,r,1, chlorosis,asiderotic anaemia,128,1,r,1, chlorosis, ...
Drugs: Sulfonamides, barbiturates, chlorpropamide, thiazide diuretics, phenytoin, salicylates, allopurinol, chlormezanone, ...
Diazepam group of drugs and Chlormezanone to your cramping muscles with either in the regulation of muscle tone to be a ...
Chlormezanone. Leghemoglobin. Tranylcypromine. Pyridine. Petroselinic Acid. Teriflunomide. Bismuth Valerate, Basic. ...
  • Known drugs associated with an SJS/TEN reaction include antibacterial sulfonamides, antiepileptic drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) of the oxicam type, allopurinol, chlormezanone, and corticosteroids. (clinicaladvisor.com)
  • Chlormezanone (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant. (wikipedia.org)
  • Within days gone by 10 years, many reports, including a few of our personal, show that ACPAs can promote an inflammatory response through supplement activation, Chlormezanone (Trancopal) development of neutrophil extracellular traps, and immediate binding to essential players, including monocytes, osteoclasts, and osteoblasts, in the mediation of bone tissue devastation in the joint parts of RA sufferers. (azadright.com)
  • Function OF ANTI-CITRULLINATED Proteins ANTIBODIES IN THE PATHOGENESIS OF ARTHRITIS RHEUMATOID An initial theory for how ACPAs and Chlormezanone (Trancopal) proteins citrullination could take part in the pathogenesis of RA originated from observation of geneCenvironment relationship in RA sufferers. (azadright.com)
  • V. M. Shinde and R. Raman, "Simultaneous method for determination of paracetamol and chlormezanone in tablets by RP-HPLC ", Indian Drugs, vol. 35, no. 8, pp. 521-23, 1998. (i-scholar.in)
  • Chlormezanone (1996): because of serious cases of toxic epidermal necrolysis. (desdaughter.com)
  • Ten microliters of plasma from each healthy and preeclampsia patients were Chlormezanone incubated with 0.5 ηg biotinylated CTB or 0.5 ηg biotinylated AV in 100 μL binding buffer (2.5 mM calcium chloride, 0.01 M Hepes [Life Technologies, Grand Island, NY], and 0.14 M sodium chloride) for 30 minutes at 37°C in a rotating tube. (p450inhibitors.com)
  • In our study, the CD1a induction was seen in response to two preparations of recombinant mature IL-1β (17Kd) that were free of detectable Chlormezanone lipopolysaccharide (data not shown). (nartsignaling.com)
  • Chlormezanone (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant. (wikipedia.org)
  • Four hundred patients with painful muscle spasm caused by five common musculoskeletal diseases were included in a double-blind controlled trial of chlormezanone, orphenadrine, orphenadrine/paracetomol and placebo. (nih.gov)
  • There was no significant difference between chlormezanone and placebo, but orphenadrine appeared to have a beneficial effect, presumably because of its muscle relaxant activity. (nih.gov)
  • The relief of muscle spasm and pain with chlormezanone and chlormezanone with aspirin: a blind, crossover study. (nih.gov)