Chlormadinone Acetate: An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.Megestrol: 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.Progesterone Congeners: Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.Cyproterone Acetate: An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Contraceptives, Oral: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.Contraceptives, Oral, Combined: Fixed drug combinations administered orally for contraceptive purposes.Oligomenorrhea: Abnormally infrequent menstruation.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.United States Indian Health Service: A division of the UNITED STATES PUBLIC HEALTH SERVICE that is responsible for the public health and the provision of medical services to NATIVE AMERICANS in the United States, primarily those residing on reservation lands.AlaskaIndians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Inuits: Inuktitut-speakers generally associated with the northern polar region.Federal Government: The level of governmental organization and function at the national or country-wide level.Vibrio cholerae: The etiologic agent of CHOLERA.Vibrio: A genus of VIBRIONACEAE, made up of short, slightly curved, motile, gram-negative rods. Various species produce cholera and other gastrointestinal disorders as well as abortion in sheep and cattle.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Dehydration: The condition that results from excessive loss of water from a living organism.Cholera: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.Androgen-Insensitivity Syndrome: A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.Mineralocorticoids: A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Gonadal Dysgenesis: A number of syndromes with defective gonadal developments such as streak GONADS and dysgenetic testes or ovaries. The spectrum of gonadal and sexual abnormalities is reflected in their varied sex chromosome (SEX CHROMOSOMES) constitution as shown by the karyotypes of 45,X monosomy (TURNER SYNDROME); 46,XX (GONADAL DYSGENESIS, 46XX); 46,XY (GONADAL DYSGENESIS, 46,XY); and sex chromosome MOSAICISM; (GONADAL DYSGENESIS, MIXED). Their phenotypes range from female, through ambiguous, to male. This concept includes gonadal agenesis.GermanyLabor, Obstetric: The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).Labor, Induced: Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.Labor Onset: The beginning of true OBSTETRIC LABOR which is characterized by the cyclic uterine contractions of increasing frequency, duration, and strength causing CERVICAL DILATATION to begin (LABOR STAGE, FIRST ).Labor Pain: Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.Tosyl CompoundsResearch: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Time Factors: Elements of limited time intervals, contributing to particular results or situations.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Child Abuse: Abuse of children in a family, institutional, or other setting. (APA, Thesaurus of Psychological Index Terms, 1994)Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Sex Hormone-Binding Globulin: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

Effects of intravenous administration of high dose-diethylstilbestrol diphosphate on serum hormonal levels in patients with hormone-refractory prostate cancer. (1/52)

The objective of this study was to elucidate the mechanism underlying the further suppression of serum testosterone (T) by diethylstilbestrol diphosphate (DES-DP) in patients with prostate cancer refractory to hormonal treatment. These patients received an LHRH agonist with or without a non-steroidal androgen-receptor blocker or a gestagen before DES-DP. We measured serum levels of total and free T, dihydrotestosterone (DHT), estradiol (E2), dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone (DHEA), androstenedione, cortisol, aldosterone before and during intravenous administration of high doses of DES-DP (500 or 1000 mg/day). DES-DP administration suppressed the serum levels of FSH (p=0.04) and total T (p=0.02), and eliminated free T (p=0.04) and E2 (p=0.04) from serum, while reducing serum DHEA-S to approximately two-thirds of the pretreatment level (p=0.03). In contrast, serum levels of SHBG (p=0.02) and cortisol (p=0.02) were markedly increased after DES-DP administration. The latter had no significant effect on serum levels of LH, DHT, ACTH, 17alpha-hydroxypregnenolone, 17alpha-hydroxyprogesterone, DHEA, androstenedione, or aldosterone. The results suggest that the potent suppression of circulating total T by DES-DP is caused, in part, by the inhibitory effect of DES-DP on serum DHEA-S level. In most patients, high-dose DES-DP treatment completely suppressed the serum level of free T, while possibly elevating serum SHBG and decreasing serum total T. The mechanisms that maintain the serum level of serum DHT during DES-DP treatment require further elucidation.  (+info)

Goserelin acetate with or without antiandrogen or estrogen in the treatment of patients with advanced prostate cancer: a multicenter, randomized, controlled trial in Japan. Zoladex Study Group. (2/52)

OBJECTIVE: The aims of this randomized, controlled study were to investigate the efficacy and safety of long-term monotherapy with the luteinizing hormone-releasing hormone agonist goserelin acetate compared with both short- and long-term combined androgen blockade. METHODS: Patients with advanced prostate cancer (n = 371) were randomized to treatment with goserelin acetate alone or a combination of goserelin acetate plus either long-term or short-term antiandrogen (chlormadinone acetate) or short-term estrogen (diethylstilbestrol diphosphate). RESULTS: There were no significant differences between the treatment groups with respect to objective progression, overall survival or disease-specific survival. Nevertheless, subgroup analysis suggested that patients with minimal disease or a good prognosis might benefit more from combined androgen blockade than other patients. Combined androgen blockade significantly reduced the incidence of disease flare compared with goserelin acetate treatment alone. CONCLUSIONS: Neither short- nor long-term combined androgen blockade had a survival advantage over goserelin acetate alone.  (+info)

Early results of LH-RH agonist treatment with or without chlormadinone acetate for hormone therapy of naive localized or locally advanced prostate cancer: a prospective and randomized study. The Prostate Cancer Study Group. (3/52)

BACKGROUND: The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for those patients. In this situation, primary hormone therapy is an alternative treatment option. We have designed a prospective randomized study of the effects of primary hormone therapy for such patients. METHODS: A total of 151 patients with T1b, T1c, T2a, T2b or T3a prostate cancer who were not scheduled for radical prostatectomy were enrolled into this study. Patients were randomly allocated into two groups; Group I received luteinizing hormone-releasing hormone (LH-RH) agonist monotherapy (leuprorelin acetate depot, 3.75 mg monthly) and Group II received LH-RH agonist in combination with chlormadinone acetate (100 mg/day). Effects on serum prostate-specific antigen level, progression-free survival and survival were observed for 2 years. RESULTS: The reasons why radical prostatectomy was not scheduled were poor risk for surgery (38%), patient's wish (32%) and physician's recommendation (30%). After 12 weeks of treatment, 49% of the patients in both groups showed a complete response (CR). Of the patients showing a partial response (PR) after 12 weeks of treatment, 25% in Group I and 52% in Group II improved to CR 1 year later (p<0.05). Group II showed a longer progression-free survival (p <0.05). Progression-free survival rates were 62% (Group I) and 91% (Group II) in T2b patients and 43% (Group I) and 73% (Group II) in T3 patients. Only one patient in each group died from prostate cancer. CONCLUSIONS: Early primary hormone therapy is a reasonable treatment option for localized or locally advanced prostate cancer patients if radical prostatectomy was not scheduled. Chlormadinone acetate showed an additive effect with LH-RH agonist, at least in 2 years' observation.  (+info)

The progestin levonorgestrel induces endothelium-independent relaxation of rabbit jugular vein via inhibition of calcium entry and protein kinase C: role of cyclic AMP. (4/52)

The progestin and oestrogen component of oral contraceptives have been involved in the development of venous thromboembolic events in women. In the present study we determined the vasoactive effects of sex steroids used in oral contraceptives in isolated preconstricted rabbit jugular veins in the presence of diclofenac and examined the underlying mechanisms. The natural hormone progesterone, the synthetic progestins levonorgestrel, 3-keto-desogestrel, gestodene and chlormadinone acetate, and the synthetic estrogen 17 alpha-ethinyloestradiol induced concentration-dependent relaxations of endothelium-intact veins constricted with U46619. Levonorgestrel also inhibited constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). In addition, levonorgestrel depressed contractions evoked by Ca(2+) and reduced (45)Ca(2+) influx in depolarized veins. Relaxations to levonorgestrel in U46619-constricted veins were neither affected by the presence of the endothelium nor by the inhibitor of soluble guanylyl cyclase, NS2028, but were significantly improved either by the selective cyclic AMP phosphodiesterase inhibitor rolipram or in the absence of diclofenac, and decreased by the protein kinase A inhibitor, Rp-8-CPT-cAMPS. Rolipram also potentiated relaxations to levonorgestrel in PMA-constricted veins in the presence, but not in the absence of extracellular Ca(2+). Levonorgestrel increased levels of cyclic AMP and inhibited PMA-induced activation of protein kinase C in veins. These findings indicate that levonorgestrel caused endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase C activation. In addition, the cyclic AMP effector pathway contributes to the levonorgestrel-induced relaxation possibly by depressing Ca(2+) entry.  (+info)

Effects of a new steroidal aromatase inhibitor, TZA-2237, and/or chlormadinone acetate on hormone-induced and spontaneous canine benign prostatic hyperplasia. (5/52)

OBJECTIVE: It has been known for many years that human benign prostatic hyperplasia (BPH) is composed predominantly of hyperplastic stromal cells rather than epithelial cells. In the present study the effects of a new steroidal aromatase inhibitor on hormone-induced and spontaneous canine BPH were investigated. METHODS: (1) Effects of TZA-2237 on hormone-induced canine BPH. Ten castrated beagles were administered testosterone and androstenedione 6 days/week for 8 months, and divided randomly into three groups after 2 months of treatment as follows. Group I served as controls, Group II was given 0.5 and Group III was given 2.5 mg/kg/day TZA-2237 5 days/week for 6 months. (2) Effects of TZA-2237 on spontaneous canine BPH. Twenty aged beagles with BPH were divided into five groups, Group IV was untreated, Group V was treated with 1 and Group VI with 5mg/kg/day TZA-2237 5 days/week for 31 weeks. Group VII was treated with 5mg/kg/day Atamestane and Group VIII was treated with 0.3 mg/kg/day chlormadinone acetate (CMA) 5 days/week. (3) Effects of TZA-2237 combined with CMA on spontaneous canine BPH. Three aged beagles with BPH were treated with 1mg/kg/day TZA-2237 and 0.03 mg/kg/day CMA 5 days/week for 20 weeks (Group IX) and a further three aged beagles with BPH were treated with 0.3 mg/kg/day CMA alone 5 days/week (Group X). RESULTS: Hormone-induced prostatic growth was significantly suppressed in group III compared with that in other groups. In Group III, the intraprostatic aromatase activity, estradiol level and androgen receptor content decreased significantly in comparison with the values in Group I. The prostatic weights in Groups V, VI and VII increased significantly in comparison with the weight in Group IV. Serum LH and testosterone levels in Groups V, VI, and VII increased significantly in comparison with the level in Group IV. The prostatic weight in Group IX was decreased only slightly, but the smooth muscle component was decreased significantly. CONCLUSIONS: TZA-2237 is a new, unique and effective aromatase inhibitor that causes inhibition of both epithelial and stromal compartments in hormone-induced canine BPH. Dual inhibition of androgen and estrogen resulted in inhibition of smooth muscle growth, and should prove effective as a new method of treatment given the atrophic effects on not only the epithelium but also the stroma in human BPH.  (+info)

Regression of prostatic hypertrophy by osaterone acetate in dogs. (6/52)

The prostatic regression effect of oral administration of a new steroidal anti-androgen, osaterone acetate, was investigated in dogs with prostatic hypertrophy. To dogs with prostatic hypertrophy, 0.1-1.0 mg/kg of osaterone acetate was orally administered for one week, and the regression rate was observed. It was shown that administration of osaterone acetate at 0.2 mg/kg or higher, sharply regressed prostatic hypertrophy during the early stage. Therefore, this agent may be clinically applicable as a therapeutic agent for benign prostatic hypertrophy.  (+info)

A prospective randomized multicenter study of chlormadinone acetate versus flutamide in total androgen blockade for prostate cancer. (7/52)

BACKGROUND: A randomized multicenter study was conducted to investigate the efficacy of total androgen blockade (TAB) for patients with previously untreated prostate cancer using the steroidal anti-androgen chlormadinone acetate (CMA) and the non-steroidal anti-androgen flutamide. We also compared the liver dysfunction in these two arms. METHODS: From November 1995 to October 1997, 71 patients were registered into this study and 70 of them were eligible. RESULTS: There was no significant difference in the efficacy of TAB between CMA and flutamide at 24 weeks. The testosterone and prostate-specific antigen (PSA) levels in patients administered flutamide (Group II) increased significantly 3 days after the first dose of LH-RH analog, whereas no such increase was observed in patients administered CMA (Group I), indicating that CMA prevented the flare-up. Parameters of liver function, serum GOT and GPT levels, which were normal at the baseline, became abnormal in 30.0% and 35.3%, respectively, of patients in Group II. These figures were significantly higher than the corresponding figures of 6.3% and 12.5%, respectively, in Group I. When the degree of change in each of these parameters was analyzed, both GOT and GPT levels showed a significantly greater increase in Group II than in Group I. CONCLUSION: These results indicate that attention must be paid to changes in liver function during the administration of flutamide in patients with prostate cancer even if their baseline liver function is normal. It is also suggested that CMA may be better tolerated from the viewpoint of the drug effects on liver function.  (+info)

Charge movements in intact amphibian skeletal muscle fibres in the presence of cardiac glycosides. (8/52)

1. Intramembrane charge movements were examined in intact voltage-clamped amphibian muscle fibres following treatment with cardiac glycosides in the hypertonic gluconate-containing solutions hitherto reported to emphasise the features of q(gamma) at the expense of q(beta) charge. 2. The application of chlormadinone acetate (CMA) at concentrations known selectively to block Na(+)-K(+)-ATPase conserved the steady-state voltage dependence of intramembrane charge, contributions from delayed (q(gamma)) charging transients, and their inactivation characteristics brought about by shifts in holding potential. 3. The addition of either ouabain (125, 250 or 500 nM) or digoxin (5 nM) at concentrations previously reported additionally to influence excitation-contraction coupling similarly conserved the steady-state charge-voltage relationships, Q(V), in fully polarised fibres to give values of maximum charge, Q(max), transition voltage, V*, and steepness factor, k, that were consistent with a persistent q component as reported on earlier occasions (Q(max) approximately = 25-27 nC F-1, V* approximately = -45 to -50 mV, k approximately = 7-9 mV). 4. In both cases shifts in holding potential from -90 to -50 mV produced a partial inactivation that separated steeply and more gradually voltage-dependent charge components in agreement with previous characterisations. 5. However, charge movements that were observed in the presence of either digoxin or ouabain were monotonic decays in which delayed (q(gamma)) transients could not be distinguished from the early charging records. These features persisted despite the further addition of chlormadinone acetate over a 10-fold concentration range (5-50 microM) known to displace ouabain from the Na(+)-K(+)-ATPase. 6. Ouabain (500 nM) restored the steady-state charge movement that was previously abolished by the addition of 2.0 mM tetracaine in common with previous results of using ryanodine receptor (RyR)-specific agents. 7. Perchlorate (8.0 mM) restored the delayed 'on' relaxations and increased the prominence of the 'off' decays produced by q(gamma) charge following treatment with cardiac glycosides. This was accompanied by a negative (approximately 10-15 mV) shift in the steady-state charge-voltage relationship but an otherwise conserved maximum charge, Q(max), and steepness factor, k, in parallel with previously reported effects of perchlorate following treatments with RyR-specific agents. 8. The features of cardiac glycoside action thus parallel those of other agents that act on RyR-Ca(2+) release channels yet influence the kinetics but spare the steady-state properties of intramembrane charge.  (+info)

*Chlormadinone acetate

... delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, and osaterone acetate. CMA ... Chlormadinone acetate is the generic name of the drug and its INN, USAN, BAN, and JAN. CMA is marketed under a variety of brand ... CMA is the acetate ester of chlormadinone, which, in contrast to CMA, was never marketed. CMA has been used in the treatment of ... Chlormadinone acetate (abbreviated as CMA), sold under many brand names, is a progestin and antiandrogen. It is used as a ...

*Amadinone

An acetate ester, amadinone acetate, also exists, but similarly was never marketed. Chlormadinone Chlormadinone acetate J. Elks ...

*Edogestrone

These include Delalutin, Chlormadinone acetate, and PH-218. It would appear that decreased androgen production is a property ... Similarly to the structurally related steroid cyproterone acetate, edogestrone binds directly to the androgen receptor and ... antagonizes it, displacing androgens like testosterone from the receptor, though not as potently as cyproterone acetate. The ...

*Clogestone acetate

... produces chlormadinone acetate as an active metabolite. List of steroidal progestogens List of progestogen ... Clogestone acetate (USAN) (developmental code name AY-11440), also known as chlormadinol acetate or as 3β,17α-diacetoxy-6- ... Stern, Michael D.; Givner, Morris L. (1975). "MEASUREMENT OF SERUM CLOGESTONE ACETATE (AY-11, 440) BY A RADIORECEPTOR ASSAY: ... Clogestone acetate, a new orally effective progestagen]". Arch Gynakol (in German). 209 (2): 136-48. PMID 5537778. ...

*Comparison of bicalutamide with other antiandrogens

SAAs include CPA, megestrol acetate, chlormadinone acetate, and spironolactone. These drugs are steroids, and similarly to ... acetate] (Androcur) and megestrol [acetate], or nonsteroidal, including flutamide (Eulexin, others), bicalutamide (Casodex), ... cyproterone acetate and megestrol acetate". Molecular and Cellular Endocrinology. 42 (3): 283-8. doi:10.1016/0303-7207(85)90059 ... Cyproterone acetate was one of the first steroidal antiandrogen clinically used but its side-effects, especially the ...

*Steroidal antiandrogen

Chlormadinone acetate (Prostal): A combined AR antagonist and progestogen/antigonadotropin. Also has weak glucocorticoid ... Inocoterone acetate (RU-38882, RU-882): A steroid-like NSAA. It was under development as a topical medication for the treatment ... Nomegestrol acetate (Lutenyl): Progestin with AR antagonist activity. Used in the treatment of gynecological disorders and in ... Megestrol acetate (Megace): A combined AR partial antagonist and progestogen/antigonadotropin. Also has weak androgenic and ...

*Hydroxyprogesterone caproate

... chlormadinone acetate, cyproterone acetate, gestonorone caproate (norhydroxyprogesterone caproate), hydroxyprogesterone acetate ... hydroxyprogesterone heptanoate, medroxyprogesterone acetate, and megestrol acetate. Along with hydroxyprogesterone acetate, ... These include Delalutin [hydroxyprogesterone caproate], chlormadinone acetate, and PH-218. It would appear that decreased ... chlormadinone acetate,27 and medrogestone (6-methyl-6-dehydro-17-methylprogesterone).50 These drugs should have a beneficial ...

*Jenapharm

Chlormadinone acetate was the first oral contraceptive produced by Jenapharm. It was sold under the name Ovosiston starting in ... a combination of ethinylestradiol sulfonate and norethisterone acetate. The other product that resulted from this collaboration ... and subsequently progesterone and desoxycorticosterone acetate in 1954/1955. In that decade research and production continued ...

*Amadinone acetate

It is the acetate ester of amadinone, which, similarly, was never marketed. Chlormadinone acetate List of progestogen esters J ... Amadinone acetate (USAN) (developmental code name RS-2208), also known as 19-norchlormadinone acetate, is a steroidal progestin ...

*Chlormadinone

While chlormadinone is sometimes used as a synonym for chlormadinone acetate, what is almost always being referred to is ... Chlormadinone (INN, BAN) is a steroidal progestin which was never marketed. An acylated derivative, chlormadinone acetate, is ... chlormadinone acetate and not chlormadinone. Cyproterone Delmadinone Hydromadinone Medroxyprogesterone Megestrol F.. Macdonald ...

*Hirsutism

Examples include birth control pills containing cyproterone acetate, chlormadinone acetate, drospirenone, and dienogest. ... It has been found to possess equivalent or greater effectiveness than spironolactone, cyproterone acetate, and finasteride in ... April 2008). "Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in ... An antimineralocorticoid with additional antiandrogenic activity at high dosages Cyproterone acetate: A dual antiandrogen and ...

*Birth control pill formulations

2000 µg chlormadinone acetate (EU: Belara, Benelux: Bellina; Gedeon Richter) 2000 µg dienogest (AU, EU: Valette, RU: Jeanine, ... 2000 µg cyproterone acetate: only approved for severe acne or severe hirsutism in the UK (AU, RU: Diane-35, UK: Dianette, Bayer ... 2.5 mg nomegestrol acetate: 24-day cycle + 4 placebo pills (AU, EU, RU: Zoely, MSD) 25 µg ethinylestradiol: triphasic ... 1000 µg norethisterone acetate: 24 days + 4 days ferrous fumarate only (US: Loestrin 24 Fe, Warner Chilcott) 90 µg ...

*17α-Hydroxyprogesterone

Among others, this class of drugs includes chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, ... medroxyprogesterone acetate, and megestrol acetate. Hydroxyprogesterone is the generic name of 17α-OHP and its INN and BAN. 11α ... However, esters of 17α-OHP, including hydroxyprogesterone caproate, as well as hydroxyprogesterone acetate and ...

*Cyproterone acetate

Megestrol acetate, medroxyprogesterone acetate, and chlormadinone acetate, steroidal progestins and close analogues of CPA, all ... The effects of flutamide and the steroidal derivatives, cyproterone acetate, chlormadinone acetate, megestrol acetate and ... 12-fold more potent than medroxyprogesterone acetate, and 3-fold more potent than chlormadinone acetate. CPA is also reportedly ... like spironolactone and other steroidal antiandrogens such as chlormadinone acetate and medroxyprogesterone acetate, is not ...

*Osaterone acetate

It is a 17α-hydroxyprogesterone derivative and a derivative of the less potent chlormadinone acetate. The drug is the C17α ... Osaterone acetate produces remission of clinical symptoms of BPH in ~83% of dogs for six months after a single one-week course ... Osaterone acetate (brand name Ypozane; former developmental code name TZP-4238), also known as 17α-acetoxy-6-chloro-2-oxa-6- ... Osaterone acetate has virtually no estrogenic or androgenic activity. However, it can decrease cortisol levels, interfere with ...

*Progestin

... including megestrol acetate, medroxyprogesterone acetate, cyproterone acetate, and chlormadinone acetate have been used to ... include chlormadinone acetate, cyproterone acetate, dienogest, drospirenone, medrogestone, megestrol acetate, nomegestrol ... Progestins that have been used for such purposes include chlormadinone acetate, cyproterone acetate, gestonorone caproate, ... These include the pregnanes medroxyprogesterone acetate and cyproterone acetate, the norpregnane segesterone acetate, and the ...

*Antigonadotropin

... potent ones such as medroxyprogesterone acetate and chlormadinone acetate are often used at high doses specifically for their ... Chassard D, Schatz B (2005). "[The antigonadrotropic activity of chlormadinone acetate in reproductive women]". Gynécologie, ... Moltz L, Römmler A, Post K, Schwartz U, Hammerstein J (April 1980). "Medium dose cyproterone acetate (CPA): effects on hormone ... Some antigonadotropins have a multimodal action, such as cyproterone acetate, which exerts its effects via acting as an ...

*Antiandrogen

These drugs include the steroidal antiandrogens cyproterone acetate, megestrol acetate, chlormadinone acetate, spironolactone, ... chlormadinone acetate and megestrol acetate are steroidal antiandrogens that are weaker than cyproterone acetate but were also ... progestogens like chlormadinone acetate, cyproterone acetate, gestonorone caproate, medroxyprogesterone acetate, megestrol ... Aside from cyproterone acetate and chlormadinone acetate, a few other progestins used in oral contraceptives and/or in ...

*List of antiandrogens

17α-Hydroxyprogesterone derivatives Chlormadinone acetate Cyproterone acetate Megestrol acetate Osaterone acetate 19- ... chlormadinone acetate, cyproterone acetate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) List of ... Abiraterone acetate Ketoconazole Seviteronel Aminoglutethimide Alfatradiol Dutasteride Epristeride Finasteride Saw palmetto ... Norprogesterone derivatives Nomegestrol acetate 19-Nortestosterone derivatives Dienogest Oxendolone 17α-Spirolactone ...

*Ethynerone

... chlormadinone acetate, medroxyprogesterone acetate, and megestrol acetate produced similar mammary gland tumors, and that their ... Subsequent investigation found that 17α-hydroxyprogesterone derivatves included anagestone acetate, ...

*List of progestogens available in the United States

Ethinylestradiol and medroxyprogesterone acetate (Provest) Mestranol and chlormadinone acetate (C-Quens, Estalor) Mestranol and ... Acetomepregenol Algestone Algestone acetophenide Allylestrenol Chlormadinone acetate Cyproterone acetate Demegestone ... Norvinisterone Oxendolone Pentagestrone acetate Promegestone Quingestanol acetate Quingestrone Segesterone acetate (nestorone) ... Medroxyprogesterone acetate (Amen, Curretab, Cycrin, Provera) - 2.5 mg, 5 mg, 10 mg Megestrol acetate (Megace) - 20 mg, 40 mg ...

*Chloroethynylnorgestrel

... including chlormadinone acetate, medroxyprogesterone acetate, and megestrol acetate, from various markets as contraceptives ( ... This resulted in the discontinuation of its development, along with that of ethynerone and anagestone acetate, as well as the ... In combination with mestranol, similarly to ethynerone and anagestone acetate (and certain other progestogens, including ... Mestranol, ethynerone, mestranol-ethynerone, chloroethynyl norgestrel-mestranol, and anagestone acetate-mestranol combinations ...

*List of corticosteroids

... various progesterone derivative progestins such as chlormadinone acetate, cyproterone acetate, medrogestone, ... medroxyprogesterone acetate, megestrol acetate, and segesterone acetate possess weak glucocorticoid activity which can manifest ... 20-dione Prebediolone acetate (21-acetoxypregnenolone) = 3β,21-dihydroxypregn-5-en-20-one 21-acetate In addition to the above, ... 21-acetate Halcinonide = 9α-fluoro-11β,16α,17α-trihydroxy-21-chloropregn-4-ene-3,20-dione cyclic 16α,17α-acetal with acetone ...

*List of steroidal antiandrogens

11α-Hydroxyprogesterone = 11α-hydroxyprogesterone Chlormadinone acetate = 17α-acetoxy-6-chloro-δ6-progesterone Clometerone (L- ... 17α-dimethyl-δ6-progesterone Megestrol acetate = 17α-acetoxy-δ6-6-methylprogesterone Nomegestrol acetate = 17α-acetoxy-δ6-6- ... methyl-19-norprogesterone Osaterone acetate (TZP-4238) = 17α-acetoxy-6-chloro-2-oxa-δ6-progesterone Benorterone (SKF-7690, FC- ... 2α-methylene-6-chloro-δ6-17α-hydroxyprogesterone Cyproterone acetate = 1,2α-methylene-6-chloro-δ6-17α-acetoxyprogesterone ...

*Pregnadiene

Chlormadinone acetate (progestin) Cyproterone acetate (antiandrogen) Dydrogesterone (progestin) Megestrol acetate (progestin, ...

*Progestogen ester

A variety of analogues of medroxyprogesterone acetate, such as chlormadinone acetate, cyproterone acetate, and megestrol ... megestrol acetate, cyproterone acetate, and hydroxyprogesterone caproate, the 19-norprogesterone derivative nomegestrol acetate ... The new progestational agent was [6α-methyl-17α-hydroxyprogesterone acetate] or [medroxyprogesterone acetate], which Upjohn has ... medroxyprogesterone acetate, and cyproterone acetate, are highly active themselves (and in fact far more active than their ...
Molbase provides you with 125 Chlormadinone acetate supplier/manufactures information,includeing Chlormadinone acetate suppliers giving product prices,purity,lead time.
Chlormadinone acetate (abbreviated as CMA), sold under many brand names, is a progestin and antiandrogen. It is used as a hormonal contraceptive in combination with estrogen (under the brand name Belara) and in the treatment of gynecological disorders. It is also used in the treatment of prostate cancer in Japan. CMA is the acetate ester of chlormadinone, which, in contrast to CMA, was never marketed. CMA has been used in the treatment of vaginal bleeding, oligomenorrhea, polymenorrhea, hypermenorrhea, secondary amenorrhea, and endometriosis. It is also used as a hormonal contraceptive in combination with ethinylestradiol. CMA has been widely used in the treatment of prostate cancer in Japan, but has seen little use for indication elsewhere in the world. CMA is used at dosages of 1 to 2 mg/day in oral contraceptives, at dosages of 2 to 10 mg/day in the treatment of gynecological disorders, and at dosages of 50 to 100 mg/day in the treatment of prostate disorders. The human receptor binding and ...
Introduction. Hyperandrogenism produces change in quality of life of women. Aim. To prespectively determine the changes of the sexual behaviour of hyperandrogenic women using an oral contraceptive containing 30 mg ethinylestradiol and 2 mg chlormadinone acetate (EE/CMA). Methods. Seventy-two volunteer women (age range, 18-32 years), with moderate to severe hirsutim and acne were treated with EE/CMA for 9 cycles. Main Outcomes Measure(s). To assess hirsutism, the Ferriman-Gallwey (F-G) scoring system was used. Serum FSH, LH, estradiol, total and free testosterone, DHEAS, androstenedione, and SHBG levels were measured at baseline and at the 9th cycle of pill intake. The Short Personal Experience Questionnaire (SPEQ), the Short Form-36 (SF-36), and a visual analog scales questionnaires were used to assess the QoL, at baseline and after 3, 6 and 9 cycles of pill use. Result(s). A reduction of 65% and 81% in the total mean F-G score was observed after the 6th cycle and the 9th cycle, respectively. ...
Hydroxyprogesterone caproate yog ib tug steroidal progestin thiab derivative ntawm 17a-hydroxyprogesterone (17a-OHP) uas muaj feem xyuam nrog lwm 17a-OHP derivatives xws li chlormadinone acetate, cyproterone acetate, medroxyprogesterone acetate, thiab megestrol acetate.Nws yog ib qho ester ntawm 17α-OHP tsim los ntawm caproic acid (hexanoic acid).
The oral contraceptive chlormadinone acetate has been given for eight months to a woman who had developed jaundice during four pregnancies, and twice while taking a combined contraceptive pill. No side-effects or changes in liver function were observed. This is further evidence that progestogens used for contraception, and in particular those derived from hydroxyprogesterone, are less hepatotoxic than the oestrogenic components.. ...
0047]One preferred embodiment of the invention relates to the use of a retinoid selected from the group consisting of acitretin [9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid], etretinate [ethyl 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate]- , isotretinoin [3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoi- c acid] and tretinoin [3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid], optionally an oestrogen component selected from the group consisting of oestradiol and ethinyl oestradiol and optionally a gestagen component selected from the group consisting of chlormadinone acetate, 3β-hydroxychlormadinone acetate (17α-acetoxychloropregna-4,6-dien-3β-ol-20-one) and 3α-hydroxychlormadinone acetate (17α-acetoxychloropregna-4,6-dien-3α-ol-20-one) for producing a dosage form in the form of the above-described daily units A and hormone-free daily units B for preventing and/or for treating ...
A multicentre randomised clinical trial was performed to compare the therapeutic potential of osaterone acetate with that of delmadinone acetate in the treatment of benign prostatic hyperplasia in dogs. The osaterone was administered orally at 0·25 mg/kg bodyweight once a day for seven days to 73 dogs. The delmadinone was administered by a single intramuscular or subcutaneous injection at 3 mg/kg bodyweight to 69 dogs. During the 180-day trial, the dogs were monitored five times for their clinical signs and prostate volume. The two drugs were similarly effective in reducing the clinical signs and inducing complete clinical remission, and both induced a similar level of minor, mostly transitory adverse effects. Osaterone reduced the volume of the prostate glands of the dogs significantly more quickly than delmadinone.. ...
steroids"[mesh] OR "Glucocorticoids "[Pharmacological Action] OR "Glucocorticoids"[Mesh] OR "Adrenal Cortex Hormones"[Mesh] OR adrenalcorticoid* OR androstane* OR androsten* OR cardanolide* OR cholen* OR cholic OR cholestan* OR cholesten* OR spirostan* OR sterol* OR cyclosteroid* OR estran* OR gonane* OR homosteroid* OR testolacton* OR hydroxysteroid* OR ketosteroid* OR ketosteroid* OR norsteroid* OR norandrostan* AND norpregnan* OR pregnane* OR pregnanol* OR pregnatri* OR Pregnen* OR tetrahydrocort* OR sapogenin* OR secosteroid* OR "vitamin D" OR cholecalciferol OR hydroxycholecalciferol* OR ergocalciferol* OR "hydroxyvitamin D" OR dihydrotachysterol OR chlormadinone* OR cyproteron* OR steroid OR steroids OR steroidal OR corticosteroid* OR Glucocorticosteroid* OR Betamethasone OR Budesonide OR clobetasol OR Cortisone OR Dexamethasone OR diflucortolon* OR fludrocortisone OR flumethason* OR fluocinolon* OR fluocinonid* OR flucortolon* OR fluorometholon* OR fluoxymesteron* OR fluprednisolon* OR ...
Clomid cycle, more sometimes medicine in geometric and sustained life, insomnia and incest influenza, and in drug post has been destroyed. His knick refused up in an incidence to keep off the drugs while at the due specialist his syndrome seemed up the mental effect, recurring the media dusts. Clomid cycle, during blood 4, seymours sensitive unit was known into the tutor. They signed and inspired in st. cepheids genexpert is by significantly the fastest and easiest of the three, but it is then the most adverse. Clomid cycle, this television of cannabis lamotrigine has also been returned to be medieval-themed and criminal. Within the ovarial number, amount in the valvulopathy and use wholesalers and suspected and named in skin actually, clomid cycle. While cases can cross prognosis, they reveal therefore respectively and with gradual relief crowds. Soon, the attempt spent to be elevated. Chlormadinone treatment was the continued deep biopsy held by jenapharm, clomid cycle days. Ozzy begins to ...
Synonyms for Prostatic hypertrophy in Free Thesaurus. Antonyms for Prostatic hypertrophy. 1 synonym for benign prostatic hyperplasia: BPH. What are synonyms for Prostatic hypertrophy?
Benign prostatic hypertrophy (BPH) is the condition commonly known as an enlarged prostate. BPH is extremely common; its the main reason many older men have trouble urinating. Usually, BPH is more of a nuisance than a major medical problem, though serious complications can occasionally occur.
BPH symptom score - symptom severity score sheet used to evaluate patients w/ benign prostatic hypertrophy. Try Equation & Browse Full Collection.
Heart failure (HF) and benign prostatic hypertrophy (BPH) are two conditions that commonly coexist in men 60 years and older. Carvedilol is the only β-adrenergic blocker approved for HF that also has additional α1-adrenergic blockade. As α1-adrene
Learn about Zoladex 10.8 mg (Goserelin Acetate Implant) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
There are 3 arms to this protocol, each with 5 or 6 groups.. In Arm 1, 240 men age 20-50 will receive goserelin acetate (Zoladex) plus Androgel (or placebo). (NOTE: ARM 1 IS CLOSED TO RECRUITMENT.. In Arm 2, 200 men age 20-50 will receive goserelin acetate (Zoladex) plus Androgel (or placebo) plus anastrazole (Arimidex). NOTE: ARM 2 IS CLOSED TO RECRUITMENT... In Arm 3, 240 men age 60 to 75 will receive goserelin acetate (Zoladex) plus Androgel (or placebo). (Arm 3 is recruiting).. Subjects will be screened on the MGH General Clinical Research Center (GCRC). After obtaining informed consent for the screening procedures, subjects will undergo a complete history and physical examination. If no exclusionary findings are noted during the history and physical examination, blood will be drawn to measure hemoglobin, routine chemistries (including serum calcium, liver function tests, and creatinine), and serum levels of PTH, 25-OH vitamin D, TSH, T, and PSA.. For Arm 3, subjects who are successfully ...
Best Pharmacy To Order Flomax Generic without prescription. Flomax (Tamsulosin) is an alpha blocker used to treat symptoms of benign prostatic hypertrophy (BPH). Flomax is used in the treatment of benign prostatic hyperplasia ...
... - Benign prostatic hyperplasia (BPH), also known as benign prostatic hypertrophy, is a histologic diagnosis characterized by proliferation of the. Benign
This study compares the results of a new computer assisted evaluation programm of sonographic images of the prostate with the histological examination of t
Build: Sat Feb 17 08:59:16 EST 2018 (commit: 16064c5). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Flomax is an alpha-adrenergic drug, used to treat the symptoms of benign prostatic hypertrophy (BPH) or enlargement of the prostate gland in men. This medication relaxes the muscles...
A 60-year-old male with history of benign prostatic hypertrophy presents complaining of nausea and ... (D) Postrenal failure (E) Pyelonephritis
Medications: Blood in the urine can be an unpleasant side effect of many medications. These include: antibiotics, anticoagulants (such as aspirin), phenytoin, quinine and rifampin. If you have started any new course in medication then you should speak with your doctor.. Benign Prostatic Hypertrophy/Hyperplasia: This is an enlargement of the prostate which is harmless but which can cause pressure on other parts of the urinary tract. This will cause the feeling of needing to go to the toilet which can have a sudden onset and potentially painful urination too. It will likely be treated with surgery.. Inflamed Kidney: The kidney can become inflamed often through unknown causes and cause the lining to bleed which is passed into the urine.. Excessive Exercise: It may be a relief for some to learn that blood in the urine following prolonged and excessive exercise is relatively normal. This is because strenuous exercise and particularly running can jar the bladder.. Blockage: A blockage in the urethra ...
Endocrine pharmacology. Insulin and oral hypoglycemic. Glucocorticoids and mineralcorticoids. Estrogen and progestinic. Thyroid medications. Hypothalamic and pituitary hormones. Drugs for benign prostatic hypertrophy. Drugs for erectile dysfunction.. ...
It is an alpha-1-adrenergic blocking agent that is used for treatment of arterial hypertension and of obstructive symptoms resulting from benign prostatic hypertrophy. Oral administration once a day. Its pharmacokinetic data (moderately elevated molecular weight, high percentage of plasma protein binding and high volume of distribution) (Pfizer 2017, Kirsten 1998, Elliot 1987) probably explain the negligible excretion observed in milk (Pfizer 2017, Versmissen 2016, Jensen 2013 y 2014). Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug may be used (Anderson 2018, Schaefer 2007 p685), especially during the neonatal period and/or in case of premature infants.
Information on EC 5.3.2.3 - TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)
Dianette or Cyproterone is a synthetic medicine which comes under the class of steroidal anti-androgen, progestine and anti-gonadotropin. Antiandrogens are effective in blocking the action of hormone called testosterone.
Cyproterone Acetate CAS 427-51-0 Cyproterone acetate (abbreviated as CPA), also sold under brand names such as Androcur among others, is a synthetic, steroidal antiandrogen, progestin, and antigonadotropin.It is primarily used in the treatment of...
Goserelin (INN, USAN, BAN), or goserelin acetate, sold under the brand name Zoladex (by AstraZeneca) among others, is a medication which is used to suppress production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer. It is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist. Structurally, it is a decapeptide. It is the natural LHRH/GnRH decapeptide with two substitutions to inhibit rapid degradation. Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production. Zoladex was approved by the U.S. Food and Drug Administration in 1989 for treatment of prostate cancer. Goserelin acetate is used to treat hormone-sensitive cancers of the ...
These are those progressive obstruction to urinary flow. Acute urinary retention may arise. if the gland suddenly increases in size because of superimposed infection or congestion, or if cardiac failure develops in the elderly. Then the patient has a sudden desire to micturate but is unable to do so, and the bladder becomes tense and tender. Chronic retention may pass unnoticed for some time but there is a gradual increase in the volume of urine which remains in the bladder after micturition. Haematuria and urethral bleeding may also occur and may be the presenting symptom. On rectal examination the prostrate may feel large, elastic and uniform in consistency . When the median lobe is affected the prostate feels normal and the condition can be recognised only by cystoscopy. Transurethral resection of prostatic tissues is the treatment of choice to relive the outflow obstruction ...
Flomax (Tamsulosin) is an alpha blocker used to treat symptoms of benign prostatic hypertrophy (BPH). Flomax is used in the treatment of benign prostatic hyperplasia; urinary tract stones; overacti...
Abstract A prostatic health status index (PHSI) can serve as a quantitative yardstick for decision-making about costs, money, operative indications, operative results, and the efficacy of drug therapy. We have evolved such an index based on the conventional urological work-up by combining the signs and symptoms and the presence or absence of health for determining the economic implications of benign prostatic hypertrophy (BPH). Cost-effectiveness is the analytical tool most commonly used by economists to measure the efficiency of resource utilization for medical care. Essentially, it asks the question,
Considered subjects will be screened to determine eligibility for entry into the study. The Screening Visit must take place at least 14 days, but not more than 21 days, before the planned date of study entry (randomization and administration of the first dose of study drug on Study Day 1). The baseline evaluation of gastric emptying must be scheduled at least 7 days (in the U.S.) and 10 days (in Europe) before the Day 1 Visit. Subjects will answer questions relating to their gastroparesis symptoms in an electronic diary (like a palm pilot) beginning on the first day of the screening period.. Eligible subjects will be randomized to receive placebo or one of two dosages of TZP-102 (10mg or 20mg) once daily for 12 weeks. After randomization and administration of the first dose of study drug on Study Day 1 (the Study Entry Visit), subsequent visits to the clinic will be scheduled every two weeks during the 12-week Treatment period and 4-week Follow-Up Period.. All visits will be conducted on an ...
Enlarged prostate or benign prostatic hypertrophy (BPH) is an enlargement of the prostate gland. What is it, what causes it, and what are the risk factors? Explained, here.
Meredith G. Shields, DNP, has been a member of the Department of Urology since 2013. She completed her undergraduate studies in Biopsychology at Tufts University. She then pursued her nursing education to the highest clinical degree, completing the Doctorate of Nursing Practice at Columbia University School of Nursing in 2014. She now focuses on the medical treatment of male subfertility, sexual dysfunction and low testosterone. She also treats patients with general urological concerns including benign prostatic hypertrophy, female voiding symptoms, and urinary tract infections.. Dr. Shields sees patients at ColumbiaDoctors Midtown (51 West 51st Street, Suite 375), the Herbert Irving Pavillion at NewYork-Presbyterian Hospital (Fort Washington Avenue and 165th Street).. ...
Goserelin acetate (Zoladex, AstraZeneca ) is an injectable gonadotropin releasing hormone superagonist ( GnRH agonist ), also known as a luteinizing hormone releasing hormone (LHRH) agonist ....
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TY - JOUR. T1 - The induction of prostatic hypertrophy in the dog with androstanediol. AU - Walsh, Patrick. AU - Wilson, J. D.. PY - 1976. Y1 - 1976. N2 - The effects of androstanediol and estradiol on prostatic growth were investigated in castrate dogs. Estrogens alone resulted in no significant change in prostatic weight, whereas androstanediol produced growth comparable to that in uncastrated controls. Androstanediol plus estradiol resulted in an even more striking ncrease in prostate growth. Approximately half the animals receiving androstanediol alone and all of those receiving androstanediol plus estradiol fulfill the weight and histologic criteria for prostatic hypertrophy in the dog. Since both of these steroid hormones are presumed to be normal secretory products of the testis, it is possible that they are involved in the pathogenesis of prostatic hypertrophy in the dog.. AB - The effects of androstanediol and estradiol on prostatic growth were investigated in castrate dogs. Estrogens ...
Prostate Gland In Dogs. By Admin. An enlarged prostate gland in dogs is common in dogs that are not neutered and older dogs. The prostate gland is a sex gland in male dogs found at the base of the bladder. It partly surrounds the uretha. Prostatic gland enlargement occurs in many dogs over five years of age. Few dogs show any ill effects from it. Prostate enlargement is also known as benign prostate hyperplasia or prostatic hypertrophy.. The enlarged prostate gland usually expands in the rectum backwards when large enough, it can push forward exert pressure on the outlet of the bladder, which causes changes in the voiding pattern. This can cause frequent urination, dribbling, and loss of control of the bladder. This is not common. A very swollen prostate can cause a dog a lot of pain.. The most common prostate symptoms in dogs are difficulty in urinating and straining at stool. The feces may appear ribbon like or flat on one side. Fecal impaction or blockages do occur. One sign of fecal ...
RATIONALE: Diagnostic procedures, such as MRI and magnetic resonance spectroscopy imaging, may help in learning how well dutasteride works in patients w
Adult male rats were injected with TSAA-291 (16 beta-ethyl-17 beta-hydroxyestr-4-en-3-one), a steroidal antiandrogen, daily for 30 days at two doses, viz., 10.0 and 25.0 mg/kg. The treatment caused a dose-dependent reduction in the weights of testis, epididymis, and other accessory sex glands. In the animals that received the high dose, 50% of the rats showed spermatogenic arrest in about 20% of the seminiferous tubules and Leydig cell morphology was normal. The levels of glycerylphosphorylcholine and sialic acid were significantly reduced in the cauda epididymis of all the treated rats. There was a reduction in the number of motile spermatozoa in the cauda epididymis of rats treated with high dose of the antiandrogen. This was accompanied by a reduced number of females exhibiting spermatozoa in their vaginal smears. A combination treatment of the antiandrogen and androgen appears to be a promising approach for fertility regulation in the male.
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men - NEJM, 9/10/12 - We provided 198 healthy men 20 to 50 years of age with goserelin acetate (to suppress endogenous testosterone and estradiol) and randomly assigned them to receive a placebo gel or 1.25 g, 2.5 g, 5 g, or 10 g of testosterone gel daily for 16 weeks. Another 202 healthy men received goserelin acetate, placebo gel or testosterone gel, and anastrozole (to suppress the conversion of testosterone to estradiol) ... The percentage of body fat increased in groups receiving placebo or 1.25 g or 2.5 g of testosterone daily without anastrozole (mean testosterone level, 44+/-13 ng per deciliter, 191+/-78 ng per deciliter, and 337+/-173 ng per deciliter, respectively). Lean mass and thigh-muscle area decreased in men receiving placebo and in those receiving 1.25 g of testosterone daily without anastrozole ... The amount of testosterone required to maintain lean mass, fat mass, strength, and sexual function varied ...
BPH is also called benign enlargement of the prostate (BEP or BPE), adenofibromyomatous hyperplasia and benign prostatic hypertrophy (technically incorrect usage), is a benign (noncancerous) increase in size of the prostate. What Is BPH? The prostate is a small gland approximately the size and shape of a walnut. It sits directly below the bladder, in front of the rectum. The prostate is a part of the male reproductive tract. It produces fluid that combines with sperm to make semen. At birth, the prostate gland is tiny. When testosterone levels rise during puberty, the prostate grows rapidly, doubling in size by age 20. Growth slows down for the next two decades and the prostate usually does not cause problems for many years. Less than 10% of 30-year-old men have an enlarged prostate. When a man reaches his 40s, the prostate goes through a second growth spurt. Half of all men have an enlarged prostate by the time they reach age 60, and by age 85, 90% of men have an enlarged prostate. The prostate ...
Prostate Health by Dr. Elson Haas, It appears that common diseases among men over 50 involve the prostate sex organ (and the colon and cardiovascular system). The modern lifestyle of stress; long hours of sitting, driving or TV watching; stuffing food and emotions; eating fast food, flesh and milk products; regular intake of sugar, caffeine, and alcohol; and environmental toxicity all set the stage for chronic, debilitating and degenerative diseases, including prostate enlargement (BPH Benign Prostatic Hypertrophy) and prostate cancer.
As mens testosterone levels begin to decline after the age of 40, enlargement of the prostate gland, or benign prostatic hypertrophy (BPH) is a common health problem. Natural medicine authorities Janet Zand, OMD, L.Ac. and Whitfield Reaves, OMD, L.Ac. offer a non-drug approach to BPH.
Learn about common causes for temporary and permanent prostate enlargement, including benign prostatic hypertrophy, prostatitis, and cancer.
The root of Nettle, a perennial flowering plant, is widely used to treat benign prostatic hypertrophy (BPH), allergies, arthritis, and inflammation.
Despite the severe pain and discomfort during administration of the drug as an injection, which is one of the main benefits of the drug. The benefits of propionate may not be worth the. Buy Testabol Propionate by BRITISH DRAGON at. How to Stop Taking Finasteride. Finasteride is a prescription medication used primarily for the treatment of benign prostatic hypertrophy. How to inject, Anabolic steroids price of anabolic anabolic steroids. How to Prepare HGH Human Growth Hormone injections and. What are the benefits of wholesale. Most popular steroids Pictures of popular items. ...
Trophic Full Spectrum Saw Palmetto contain an oil with a variety of fatty acids and phytosterols that prevent and treat benign prostatic hypertrophy (BPH).
Benign prostatic hypertrophy is common as a man ages. Typical symptoms of BPH include difficulty starting urination, weak urinary stream, frequent urination, and waking up several times at night to urinate. A research suggests that Saw Palmetto can markedly improve all those symptoms without serious side effects. ...
Benign prostatic hypertrophy is common as a man ages. Typical symptoms of BPH include difficulty starting urination, weak urinary stream, frequent urination, and waking up several times at night to urinate. A research suggests that Saw Palmetto can markedly improve all those symptoms without serious side effects. ...
The most commonly studied product is Tadenan (Laboratoires DEBAT, Garches, France), which is a lipophilic extract standardised to contain 12-13% total sterols. BENIGN PROSTATIC HYPERTROPHY A Cochrane systematic review analysed the results of 18 clinical trials that involved a total of 1562 participants. Seventeen studies were double-blinded and the mean treatment duration was 61 ± 21 days (range 30-122 days). Most studies used a standardised extract of P. africanum in doses ranging from 75 to 200 mg/day. Twelve of the 13 placebo-controlled studies reported a beneficial effect on at least one parameter (overall symptoms, nocturia, peak urine flow, or residual volume), whereas one study found no significant effects. The overall summary effect size indicated a large and statistically significant improvement with P. africanum. More specifically, active treatment increased peak urine flow by 23%, reduced residual urine volume by 24% and physicians were twice as likely to report their patients were ...
Wikipedia has an article discussing finasteride and its use primarily for benign prostatic hypertrophy and certain types of male baldness. [PMID 15702134] Interaction of finasteride is more effective at blocking alcohol in carriers of two rs279858(A) alleles than in carriers of at least one rs279858(G) allele, however, study sample size was small. ...
DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID | C6H13BNO5- | CID 657085 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
... is also called benign prostatic hypertrophy. Its when the prostate gland becomes very large and may cause problems passing urine. BPH is not cancer, and is a common part of aging.
Benign prostatic hyperplasia (BPH) is also called benign prostatic hypertrophy. Its when the prostate gland becomes very large and may cause problems passing urine. BPH is not cancer, and is a common part of aging.
Next time you see your father, your uncle, or any older gentleman over age 60 or so, ask them about their prostate. If you know the guy well enough, and he feels comfortable enough around you (some would say too comfortable), he will surely share a whole litany of the common prostate problems that are troubling him, or have troubled him, or will trouble him in the near future. Thats because an enlarged prostate, benign prostatic hypertrophy, and even prostate cancer can be in the cards for every man past a certain age.. Its the scary but true fact of getting old as a man. For instance, every man should know that prostate cancer is one of the most common prostate problems out there. It tops the list of cancers that afflict men, happening in nearly as many men, roughly speaking, as breast cancer in women. Prostate cancer doesnt get the press that breast cancer does, however, probably because most men would rather not speak about whats happening down there.. The second thing most men dont, but ...
BPH is an enlarged prostate gland that can cause problems with urination. There are many treatments, including surgical and non-surgical. These can be invasive or non-evasive. BPH, also known as benign prostatic hypertrophy, is a condition in which the prostate gland becomes very enlarged and may cause problems associated with urination. BPH does not usually ...
... is prescribed for the treatment of symptoms of benign prostatic hypertrophy (enlarged prostate) or male pattern baldness.
K Fujii, H Kohrogi, S Hirosako, O Kawano, N Hirata, E Goto, M Ando. Dyspnoea and hyperventilation induced by synthetic progesterone chlorpromadinone acetate for the treatment of prostatic hypertrophy. Respirology (Carlton, Vic.). 2001 Sep;6(3):265-7 ...
Twenty-four papers from a symposium held in October 1988. The papers, with the character of critical reviews, focus on two main groups of topics: hormonal effects of smoking and possible or established relations of smoking to disorders at least potentially modulated by hormonal effects such as benign uterine and breast lesions, osteoporosis, gallstones, skin atrophy, prostatic hypertrophy, inflammatory bowel disease, parkinsonism, and cancers. A few chapters take up epidemiologic evidence or biochemical mechanisms. ...
But its not bad news.... we have some tablets that will reduce the size of the gland in a week :) and then we go for a check up in six months. Im just relieved its not spongy/lumpy or mishapen which would have been worse. Of course Im still worried but at least we caught it early (due to the colitis he had last month - thank goodness for poop! tells a whole range of things...:p)
Benign prostatic hyperplasia (BPH) is also called benign prostatic hypertrophy. Its when the prostate gland becomes very large and may cause problems passing urine. BPH is not cancer, and is a common part of aging.
BPH (also referred to as benign prostatic hypertrophy) is a condition in which the prostate gland becomes very enlarged and may cause problems associated with urination. BPH can raise PSA (prostate-specific antigen) levels two to three times higher than the normal level. An increased PSA level does not indicate cancer, but the higher the PSA level, the higher the chance of having cancer.. Some of the signs of BPH and prostate cancer are the same; however, having BPH does not seem to increase the chances of developing prostate cancer. A man who has BPH may also have undetected prostate cancer at the same time or may develop prostate cancer in the future. Therefore, the National Cancer Institute and the American Cancer Society recommend that all men over 50 consult their doctors about having a digital rectal and PSA examination once a year to screen for prostate cancer.. ...
As men age, the prostate enlarges, a condition known as benign prostatic hypertrophy, and symptoms caused by pressure on the bladder and the urethra develop. These include more frequent urination, a difficulty starting urination, pain on urinating and difficulty passing urine. In some cases, when the prostate enlarges the cells undergo a cancerous change. In many men, this happens so slowly they never know they have cancer. Some cases have been diagnosed as an "incidental finding" during the post-mortems done on men who have died from other causes. But in others, the cancerous change can be rapid and the prostate cancer can spread beyond the prostate into other organs, usually the bones of the pelvis and spine, before the man has symptoms. There is new evidence that a particular tumour gene, known as P53 indicates whether the man has a tumour likely to spread rapidly or grow slowly. If P53 is present in the tumour, it is usually a much more aggressive and dangerous cancer. ...
Next time you see your father, your uncle, or any older gentleman over age 60 or so, ask them about their prostate. If you know the guy well enough, and he feels comfortable enough around you (some would say too comfortable), he will surely share a whole litany of the common prostate problems that are troubling him, or have troubled him, or will trouble him in the near future. Thats because an enlarged prostate, benign prostatic hypertrophy, and even prostate cancer can be in the cards for every man past a certain age.. Its the scary but true fact of getting old as a man. For instance, every man should know that prostate cancer is one of the most common prostate problems out there. It tops the list of cancers that afflict men, happening in nearly as many men, roughly speaking, as breast cancer in women. Prostate cancer doesnt get the press that breast cancer does, however, probably because most men would rather not speak about whats happening down there.. The second thing most men dont, but ...
Tamsulosin, a selective α1-adrenergic receptor (α1-AR) antagonist, is a widely prescribed first-line agent for benign prostatic hypertrophy (BPH). Its interaction with anesthetic agents has not been described. We report the case of 54-year-old Asian man undergoing elective left thyroid lobectomy. The only medication the patient was taking was tamsulosin 0.4 mg for the past year for BPH. He developed persistent hypotension during the maintenance phase of anesthesia while receiving oxygen, nitrous oxide and 1% isoflurane. The hypotension could have been attributable to a possible interaction between inhalational anesthetic and tamsulosin. Vigilance for unexpected hypotension is important in surgical patients who are treated with selective α1-AR blockers. If hypotension occurs, vasopressors that act directly on adrenergic receptors could be more effective.
BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the 1940s-70s, has been shown to cause reproductive problems in the daughters. Studies of prenatally-exposed males have yielded conflicting results. METHODS: In data from a collaborative follow-up of three U.S. cohorts of DES-exposed sons, we examined the relation of prenatal DES exposure to occurrence of male urogenital abnormalities. Exposure status was determined through review of prenatal records. Mailed questionnaires (1994, 1997, 2001) asked about specified abnormalities of the urogenital tract. Risk ratios (RR) were estimated by Cox regression with constant time at risk and control for year of birth. RESULTS: Prenatal DES exposure was not associated with varicocele, structural abnormalities of the penis, urethral stenosis, benign prostatic hypertrophy, or inflammation/infection of the prostate, urethra, or epididymus. However, RRs were 1.9 (95% confidence interval 1.1-3.4) for ...
Abnormal pap smears, acne, alcoholism, altitude sickness, Alzheimers disease, arsenic poisoning, atherosclerosis (hardening of the arteries), benign prostatic hypertrophy (BPH), bone density, burns, cardiac arrhythmia (irregular heartbeat), celiac disease, cognitive disorders, cosmetic uses, Crohns disease, depression, diabetic retinopathy, diarrhea, detoxification from alcohol or toxins, Downs Syndrome, ear infections, eczema, endocrine disorders, epilepsy, fetal development, Graves disease, growth disorders (growing pains), hay fever, heart attack treatment/prevention/rehabilitation, hyperglycemia (high blood sugar), hyperlipidemia (high blood lipids), infant eye/brain development, inflammation, inflammatory bowel disease, lung disease, lupus erythematosus, lymphedema, menopausal symptoms, metabolic enhancement, miscarriage prevention, mood disorders, multiple organ failure, multiple sclerosis (MS), muscle weakness, neonatal disorders, non-Hodgkins lymphoma, pain, parasites and worms, ...
Abnormal pap smears, acne, alcoholism, altitude sickness, Alzheimers disease, arsenic poisoning, atherosclerosis (hardening of the arteries), benign prostatic hypertrophy (BPH), bone density, burns, cardiac arrhythmia (irregular heartbeat), celiac disease, cognitive disorders, cosmetic uses, Crohns disease, depression, diabetic retinopathy, diarrhea, detoxification from alcohol or toxins, Downs Syndrome, ear infections, eczema, endocrine disorders, epilepsy, fetal development, Graves disease, growth disorders (growing pains), hay fever, heart attack treatment/prevention/rehabilitation, hyperglycemia (high blood sugar), hyperlipidemia (high blood lipids), infant eye/brain development, inflammation, inflammatory bowel disease, lung disease, lupus erythematosus, lymphedema, menopausal symptoms, metabolic enhancement, miscarriage prevention, mood disorders, multiple organ failure, multiple sclerosis (MS), muscle weakness, neonatal disorders, non-Hodgkins lymphoma, pain, parasites and worms, ...
In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.21, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase ...
By Lita Lee, Ph.D.Nutritional support for prostate problemsCovers prostatic hypertrophy, prostate cancer and health effects of vasectomy and presents a nutritional support program. Prostate problems occur in the prostate gland as a man ages. After age 55, up to 60% of men suffer the effects of prostate enlargement. More than 300,000 men have surgery for enlarged prostates each year. Even worse, prostate cancer strikes 136,000 men yearly, killing 36,000. Because of histological (cellular) similarities, distinction of cancer from non-malignant changes may be difficult.
To mould over; taken to mean an increase in cell number. These are the definitions on the cellular level, but it turns out that some pathologists also use the term hypertrophy to denote a gross increase in organ size, hence the confusion. For example, when a mans prostate becomes enlarged, it is due to hyperplasia (an increase in cell number). The cellular term for this phenomenon is nodular hyperplasia. On an autopsy report, however, a pathologist would report it as prostatic hypertrophy because he or she can see the increase in size through the naked eye. Hyperplasia is a normal physiological response and it is not pathologic. A good example is the hyperplasia of the uterine lining (the endometrium) in the menstrual cycle.. ...
Top 20 individuals: 1. Ellis Coon (W) 16:28.1, 2. Matthew Fahs-Brown (M) 16:44.4, 3. Owen Glogovsky (W) 16:48.2, 4. Tyler Houvener (W) 17:08.4, 5. Nick Bergen (W) 17:21.3, 6. Jonathan Beres (W) 17:34.4, 7. Seth Cousins (Ca) 17:37.0, 8. Wesley Meyer ® 17:37.5, 9. Landrum Neer (CMA) 17:38.9, 10. Alejandro Tumoine (CMA) 17:45.3, 11. Brandon Maull (TV) 17:49.2, 12. Tyler Byerline ® 17:50.4, 13. Kennedy Schneiders ℗ 17:54.2, 14. Mason Reed ℗ 17:57.3, 15. Bryce Wanemacher (T) 18:09.0, 16. Zach Dunlap (CMA) 18:09.4, 17. Justin Matei (CMA) 8:09.7, 18. Ryan Goon (W) 18:14.0, 19. Derek Johnston (T) 18:15.6, 20. Austin Kimble ® 18:18.8 ...
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Primary signet-ring cell carcinoma (PSRCC) is a rare variation of adenocarcinoma of the urinary bladder. English literature review on pubmed reveals less than 100 cases reported. Adenocarcinoma constitutes 2% of all bladder cancers with the majority being metastatic rather than primary[1]. A study of 713 cases of primary bladder tumor in Sweden revealed 4 signet ring cell carcinomas, only 0.6% [2]. Another series of 715 bladder cancers in Germany revealed 18 adenocarcinomas but only one with the classic histologic pattern of signet-ring cell carcinoma [3]. Signet-ring cells are much more commonly described in primary adenocarcinoma of the stomach, colon, breast or gallbladder and malignancies of these organs should be excluded before diagnosing PSRCC of urinary bladder [3]. A 3:1 male to female predominance has been shown [4], but in male patients, it is especially necessary to rule out prostatic adenocarcinoma as a possible site of origin [5].. Most patients present in middle-age with symptoms ...
According to an upcoming article in the December 15th issue of Cancer (Cancer 2003;98) a research group from the Harvard Medical School, Boston, under Dr. Brian Liu describes a micro-dissection method where prostatic tissue from 17 suspected cancer patients were examined with a spectroscopic method for a new protein marker, the cellular protein PCa-24). This was found to be positive in 16 of the 17 samples. In contrast, 12 patients with benign prostatic hyperplasia (also known as BPH or "benign prostatic hypertrophy") showed no trace of this prostate cancer specific protein. As this protein is located inside the prostate cancer cell (it is a cellular protein), one has to obtain a tissue sample through a prostate biopsy. The group under Dr. Liu achieved this through laser capture micro-dissection Proteomics, which is the method that was used to characterize the prostate cancer specific protein (PCa-24), is briefly discussed under this link, but it is not necessary to understand all of the ...
The result should always be interpreted in conjunction with the findings on digital rectal examination and other clinical findings.. Marked elevation is indicative of carcinoma, but normal or slightly elevated PSA levels do not exclude it.. The most common non-malignant cause of increased PSA is benign prostatic hypertrophy. However, levels are also increased in prostatitis, prostatic ischaemia and/or infarction and acute renal failure.. Assays for total PSA should measure the free and complexed forms equally.. Specific assays are also available for each form.. The complexed form is probably more specific for prostatic cancer but the diagnostic role of complexed PSA assays is not yet established.. Results that do not correspond to the clinical findings should be repeated on a fresh sample.. PSA is most useful in monitoring the course of prostatic carcinoma.. ...
Any prostate symptom should be investigated because the enlargement may be due to a cancer. The usual screening test would be a rectal examination and a blood test for PSA (prostate specific antigen). A rectal examination alone has its limitations because it only feels the back of the prostate gland. Recently a new test to diagnose prostate cancer has become available called PCA3 available through the Doctors Laboratory - please see The Doctors Laboratory PCA test and then, if you are interested, please contact the office for more details about this test and its cost. This sample calls for cells collected in urine before and after prostatic massage. A biopsy is therefore not necessary. I am generally opposed to biopsies for cancer because this may spread cancer cells up the needle tract. The commonest cause of an enlarged prostate is "benign hypertrophy". Please see Medscape article on Benign Prostatic Hypertrophy It is generally assumed that this is as a result of lifelong exposure to ...
One in six men in this country may experience prostate health issues. One out of 2 over age 60 will get BPH, or benign prostatic hypertrophy. These two factors alone signal the need for ways to reduce mens risk of developing disease. Luckily, scientists have identified certain nutrients found in nature, as well as common micronutrients, which may play a role in prostate health. Our formula combines these well-researched ingredients in amounts known to benefit prostate health. Pumpkin seed oil, Saw Palmetto, Nettle and Pygeum contain natural DHT blockers and phytosterols. DHT is a metabolite of testosterone, which may provoke the enlargement of the prostate ...
Blackmores Proseren contains the extract of the herb Serenoa at the recommended dosage used in published clinical trials. These trials showed the extract used in Proseren provides effective relief from the troublesome symptoms of medically diagnosed Benign Prostatic Hypertrophy (benign enlargement of the prostate) such as frequent urination, hesitancy, impairment of stream and nocturia.The mechanism by which serenoa works is not fully understood but most likely involve inhibition of the enzyme 5-alpha..
Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth (for example, certain cancers, restenosis, benign prostatic hypertrophy) by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include α-alkyl-S-alkyl-homocysteine sulfoximines wherein the α-alkyl contains 2 to 8 carbon atoms, and the S-alkyl- contains 1 to 10 carbon atoms. In another invention herein, mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include, for example, repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative
CAS no.:595-33-5 Molecular Formula:C24H32O4 Molecular Weight:370.4819 Megestrol acetate is a blazon of hormone treatment. It is aswell alleged Megace or megestrol. It is a man fabricated adaptation of the hormone progesterone. Progesterone is one of the changeable sex hormones but men aswell aftermath a baby bulk of it. Megestrol acetate is a analysis for the…
Saw Palmetto berries have long held a reputation as sexual stimulants and aphrodisiacs.. The medical journal JAMA published research showing how Saw Palmetto is effective for the treatment of men with symptomatic benign prostatic hyperplasia. Saw Palmetto has shown significant action in treatment of conditions associated with benign prostatic hypertrophy (BPH). Saw Palmetto extract works to prevent testosterone from converting into dihydrotestosterone, the hormone thought to cause prostrate cells to multiply which leads to an enlarged prostate.. The effects of Saw Palmetto are a result of multiple mechanisms. One mechanism is that it relaxes smooth muscle tissue resulting in increased blood flow. Saw Palmetto also inhibits androgen and estrogen receptor activity and may be beneficial for both sexes in balancing the hormones. Because of its hormonal effects, Saw Palmetto can aid the thyroid in regulating sexual development and normalizing activity of those glands and organs. Currently, Saw ...
Tongkat Ali, also known as Long Jack, has been shown to support male hormonal balance (including testosterone availability), libido and performance, according to animal studies. Tongkat Ali is a Southeast Asian botantical used traditionally to enhance energy levels, endurance and stamina, and to reduce occasional mental fatigue. Supplement Facts Serving Size: 1 tablet Amount %DV Eurycoma longifolia Extract (Tongkat Ali LJ100™) 80 mg Other Ingredients: microcrystalline cellulose, stearic acid, modified cellulose gum, and colloidal silicon dioxide. Warning: This product is intended for use by adult men only. Not intended for use by pregnant or breastfeeding women. If you are taking any prescription medications, are taking any kind of hormone modulating supplements such as anabolic steroids or hormone replacement therapy or have any type of hormone responsive diseases or conditions such as breast or prostate cancer, benign prostatic hypertrophy, or thyroid disease, consult your
Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more: Dr. ElGendy on whats the most common cause of airway obstruction: Much more common in males + most common cause in mature men is bph, benign prostatic hypertrophy less often prostate cancer or prostatitis. Further down from prostate most common blockage is urethral stricture either from trauma, ie straddle injuries or pelvic fractures. Most common in newborn males is posterior urethral valves. In females - urethral diverticulum or skenes gland cyst.
Drug delivery systems for the transdermal administration of tamsulosin are described. The systems are in the form of laminated patches having one or more reservoirs comprised of a polymeric adhesive material containing a tamsulosin formulation. The invention also relates to a method for treating benign prostatic hypertrophy (BPH) and related conditions and diseases, by administering tamsulosin transdermally, to tamsulosin-containing pharmaceutical compositions for transdermal administration of the drug and to a low-temperature method for manufacturing a tamsulosin-containing transdermal delivery system.
Cernitin is an extract of various pollens from different plants. The active ingredients are a water-soluble (T/60) and fat-soluble (GBX) fraction. The water-soluble fraction attenuated the inflammatory response in experimental animals (7). The acetone-soluble fraction was found to consist of 3 -sterols with a similarity on UV absorption spectra to oestrone and stigmasterol (9). More recently, in vitro studies have shown that GBX inhibits cyclo-oxygenase and lipoxygenase enzyme in the eicosanoid cascade, blocking both leukotriene and prostaglandin synthesis (Loschen, personal communication). Cernitin was shown to reduce significantly the size of the ventral and dorsal prostate in the rat and to inhibit testosterone- induced prostatic hypertrophy in the castrated animal (7). Kimura et al. (1986) observed that T60 and GBX produced relaxation of the smooth muscle of the mouse and pig urethra and increased the contraction of the bladder muscle.. Although the precise mode of action of Cernitin on the ...
myworldhut presents Ayurvedic Kanchanar/Kanchnar Herb Powder Wildcrafted Bulk. Benefits and uses liver. It's an astringent tonic contains tannic acid useful in scrofula (lymph nodes of the neck), tumors, Glandular enlargement, prostatic hypertrophy, thyroid enlargement, skin diseases, ulcers, leprosy, diarrhea and dysentery, malaria,
An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]
The IUPHAR/BPS Guide to Pharmacology. cyproterone acetate ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Megestrol acetate appetite stimulant drug molecule. Also used as cancer drug in in combination contraceptives. Stylized skeletal formula (chemical structure). Atoms are shown as color-coded circles: hydrogen (hidden), carbon (grey), oxygen (red). - Stock Image F013/0525
cyproterone: a synthetic, hormonal steroid substance, related to progesterone, which is potent as an antiandrogen. A variant form is cyproterone acetate...
Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (formerly hormone-resistant or hormone-refractory prostate cancer) - i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. It is a prodrug to the active agent abiraterone, and is marketed under the trade name Zytiga.. ...
Looking for online definition of megestrol acetate in the Medical Dictionary? megestrol acetate explanation free. What is megestrol acetate? Meaning of megestrol acetate medical term. What does megestrol acetate mean?
Philipp S. Wild, Janine F. Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten J.G. Leening, Uwe Völker, Vera Großmann, Jennifer A. Brody, Marguerite R. Irvin, Sanjiv J. Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V. Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J. Gustav Smith, Claire Monnereau, Marco R. Di Tullio, Solomon K. Musani, Alanna C. Morrison, Tune H. Pers, Michael Morley, Marcus E. Kleber, AortaGen Consortium, Jayashri Aragam, Emelia J. Benjamin, Joshua C. Bis, Egbert Bisping, Ulrich Broeckel, CHARGE-Heart Failure Consortium, Susan Cheng, Jaap W. Deckers, Fabiola Del Greco M, Frank Edelmann, Myriam Fornage, Lude Franke, Nele Friedrich, Tamara B. Harris, Edith Hofer, Albert Hofman, Jie Huang, Alun D. Hughes, Mika Kähönen, KNHI investigators, Jochen Kruppa, Karl J. Lackner, Lars Lannfelt, Rafael Laskowski, Lenore J. Launer, Margrét Leosdottir, Honghuang Lin, ...
BACKGROUND. Severe gonadal steroid deficiency induces bone loss in adult men; however, the specific roles of androgen and estrogen deficiency in hypogonadal bone loss are unclear. Additionally, the threshold levels of testosterone and estradiol that initiate bone loss are uncertain.. METHODS. One hundred ninety-eight healthy men, ages 20-50, received goserelin acetate, which suppresses endogenous gonadal steroid production, and were randomized to treatment with 0, 1.25, 2.5, 5, or 10 grams of testosterone gel daily for 16 weeks. An additional cohort of 202 men was randomized to receive these treatments plus anastrozole, which suppresses conversion of androgens to estrogens. Thirty-seven men served as controls and received placebos for goserelin and testosterone. Changes in bone turnover markers, bone mineral density (BMD) by dual-energy x-ray absorptiometry (DXA), and BMD by quantitative computed tomography (QCT) were assessed in all men. Bone microarchitecture was assessed in 100 men.. RESULTS. ...
Robert at .ibm.net writes: ,Has anyone heard of the possible effects (positive or negative) of sawSaw ,Palmetto on the Prostate? Saw Palmetto is used for treatment of prostatic hypertrophy (and similar prostatic ailments), and in treatment of debilitated conditions of the male reproductive system, as well as urinary infections in males. It acts as a toning agent on the malre reporoductive system and is a urinary antiseptic. It is also useful in reducing congestive catarrhal conditions of the respiratory system. In other words, it has lots of good effects on the prostrate, particularly on a hypertrophied (enlarged) prostate. :) -- * * * * Myrddin myrddin at rabble.uow.edu.au, pdd37 at uow.edu.au * * * (042) 854482 * * Winner of the Dizzy Queen of the Month Award for the month * of May .. not one of my better months. -- * * * * Myrddin myrddin at rabble.uow.edu.au, pdd37 at uow.edu.au * * * (042) 854482 * * Winner of the Dizzy Queen of the Month Award for the month * of May .. not one of my ...
Megestrol Tablets official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Define Cyproterone acetate. Cyproterone acetate synonyms, Cyproterone acetate pronunciation, Cyproterone acetate translation, English dictionary definition of Cyproterone acetate. n. A synthetic steroid that inhibits the secretion of androgens. n an antiandrogen drug that suppresses testosterone in the body

Chlormadinone acetate - WikipediaChlormadinone acetate - Wikipedia

... delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, and osaterone acetate. CMA ... Chlormadinone acetate is the generic name of the drug and its INN, USAN, BAN, and JAN. CMA is marketed under a variety of brand ... CMA is the acetate ester of chlormadinone, which, in contrast to CMA, was never marketed. CMA has been used in the treatment of ... Chlormadinone acetate (abbreviated as CMA), sold under many brand names, is a progestin and antiandrogen. It is used as a ...
more infohttps://en.wikipedia.org/wiki/Chlormadinone_acetate

CHLORMADINONE ACETATE (CAS 302-22-7) Market Research Report 2018CHLORMADINONE ACETATE (CAS 302-22-7) Market Research Report 2018

Market Research Report 2018 aims at providing comprehensive data on chlormadinone acetate market globally and regionally ... Chlormadinone acetate prices in other regions. 7. CHLORMADINONE ACETATE END-USE SECTOR 7.1. Chlormadinone acetate market by ... 6. CHLORMADINONE ACETATE MARKET PRICES. 6.1. Chlormadinone acetate prices in Europe. 6.2. Chlormadinone acetate prices in Asia ... 2. CHLORMADINONE ACETATE APPLICATIONS. 2.1. Chlormadinone acetate application spheres, downstream products. 3. CHLORMADINONE ...
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Chlormadinone acetate(302-22-7) suppliers and manufacturers-MolbaseChlormadinone acetate(302-22-7) suppliers and manufacturers-Molbase

... includeing Chlormadinone acetate suppliers giving product prices,purity,lead time. ... Molbase provides you with 125 Chlormadinone acetate supplier/manufactures information, ... Upstream information : Progesterone, 6.α.-chloro-17-hydroxy-, acetate 3-Ethoxy-17-hydroxypregna-3,5-dien-20-one 17-acetate 6β- ... 20-dione 17-acetate,Gestafortin,Matrol; MATROL; Verton; CMA; 6-Chloro-6-dehydro-17α-acetoxyprogesterone; chlormadinone; ...
more infohttp://www.molbase.com/cas/302-22-7.html

Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate | IRIS...Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate | IRIS...

Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. ... Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate ... behaviour of hyperandrogenic women using an oral contraceptive containing 30 mg ethinylestradiol and 2 mg chlormadinone acetate ...
more infohttps://www.iris.unict.it/handle/20.500.11769/25107

China High Quality Cyproterone Acetate CAS: 427-51-0 for Contraceptive - China Cyproterone Acetate, Emergency ContraceptionChina High Quality Cyproterone Acetate CAS: 427-51-0 for Contraceptive - China Cyproterone Acetate, Emergency Contraception

Find details about China Cyproterone Acetate, Emergency Contraception from High Quality Cyproterone Acetate CAS: 427-51-0 for ... China High Quality Cyproterone Acetate CAS: 427-51-0 for Contraceptive, ... Chlormadinone acetate. 302-22-7. Cyproterone acetate. 427-51-0. Megestrol acetate. 595-33-5. ... High Quality Cyproterone Acetate CAS: 427-51-0 for Contraceptive High Quality Cyproterone Acetate CAS: 427-51-0 for ...
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Pregnancy and chlormadinone acetate. | The BMJPregnancy and chlormadinone acetate. | The BMJ

Pregnancy and chlormadinone acetate.. Br Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5684.686-b (Published 13 December ...
more infohttp://www.bmj.com/content/4/5684/686.3

Chlormadinone Acetate (IARC Summary & Evaluation, Volume 21, 1979)Chlormadinone Acetate (IARC Summary & Evaluation, Volume 21, 1979)

Chlormadinone acetate was tested in mice, rats and dogs by oral administration. When given alone to dogs, chlormadinone acetate ... CHLORMADINONE ACETATE. VOL.: 21 (1979) (p. 365) 5. Summary of Data Reported and Evaluation. (N.B. - This section should be read ... Chlormadinone acetate has been reported to be embryolethal and teratogenic when given during the organogenesis stage in some ... There is limited evidence for the carcinogenicity of chlormadinone acetate in dogs. In humans, oral contraceptives containing ...
more infohttp://www.inchem.org/documents/iarc/vol21/chlormadinoneacetate.html

Contraception with Chlormadinone Acetate in Woman with Previous Contraceptive Jaundice | The BMJContraception with Chlormadinone Acetate in Woman with Previous Contraceptive Jaundice | The BMJ

Contraception with Chlormadinone Acetate in Woman with Previous Contraceptive Jaundice Br Med J 1970; 1 :152 ... The oral contraceptive chlormadinone acetate has been given for eight months to a woman who had developed jaundice during four ... Contraception with Chlormadinone Acetate in Woman with Previous Contraceptive Jaundice. Br Med J 1970; 1 doi: https://doi.org/ ...
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Chlormadinone Acetate- CAS Number 302-22-7Chlormadinone Acetate- CAS Number 302-22-7

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The Effects of Chlormadinone Acetate on Lower Urinary Tract Symptoms and Erectile Functions of Patients with Benign Prostatic...The Effects of Chlormadinone Acetate on Lower Urinary Tract Symptoms and Erectile Functions of Patients with Benign Prostatic...

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  • It captures chlormadinone acetate market trends, pays close attention to chlormadinone acetate manufacturers and names suppliers. (marketpublishers.com)
  • The clinical utility of chlormadinone acetate tablets (Lutoral™), an orally active progestin which has been available since June 2007, was compared to an in-house vaginal suppository formulation of progesterone used between 2006 and 2007 for assisted reproductive technology (ART). (unboundmedicine.com)
  • We retrospectively evaluated the efficacy and safety of chlormadinone acetate by comparing the pregnancy rates and the incidences of birth defects and hypospadias in frozen-thawed embryo transfer cycles using the in-house vaginal progesterone and those using chlormadinone acetate for luteal phase support. (unboundmedicine.com)
  • The pregnancy rates in the frozen-thawed embryo transfer cycles were 31.2% (259/831) with vaginal progesterone for luteal phase support and 31.6% (4228/13 381) with chlormadinone acetate (no significant difference). (unboundmedicine.com)
  • These results indicate that the pregnancy rate following frozen-thawed embryo transfer using chlormadinone acetate for luteal phase support was comparable with that using vaginal progesterone, with no increased risk of birth defects, including hypospadias, which has been a concern following the use of progestins. (unboundmedicine.com)
  • VL - 18 IS - 3 N2 - Purpose: The clinical utility of chlormadinone acetate tablets (Lutoral™), an orally active progestin which has been available since June 2007, was compared to an in-house vaginal suppository formulation of progesterone used between 2006 and 2007 for assisted reproductive technology (ART). (unboundmedicine.com)
  • Chlormadinone Acetate is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. (worldofchemicals.com)
  • 2)Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. (ecrobot.com)
  • Chlormadinone acetate has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. (hisupplier.com)
  • Chlormadinone acetate acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. (hisupplier.com)
  • Chlormadinone acetate suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. (hisupplier.com)
  • Chlormadinone acetate shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. (hisupplier.com)
  • Chlormadinone acetate was tested in mice, rats and dogs by oral administration. (inchem.org)
  • In the cycles resulting in live birth following administration of chlormadinone acetate between July 2007 and December 2015, the incidence of birth defects was 2.8% (80/2893), and the incidence of hypospadias was 0.03% (1/2893). (unboundmedicine.com)
  • CHLORMADINONE ACETATE (CAS 302-22-7) Market Research Report 2018 aims at providing comprehensive data on chlormadinone acetate market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • There is limited evidence for the carcinogenicity of chlormadinone acetate in dogs. (inchem.org)
  • 3 H chlormadinone acetate from the plasma of women. (springer.com)