A highly chlorinated polycyclic hydrocarbon insecticide whose large number of chlorine atoms makes it resistant to degradation. It has been shown to be toxic to mammals and causes abnormal cellular changes in laboratory animals.
An organochlorine insecticide that is carcinogenic.
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
A potent liver poison. In rats, bromotrichloromethane produces about three times the degree of liver microsomal lipid peroxidation as does carbon tetrachloride.
CXCR receptors isolated initially from BURKITT LYMPHOMA cells. CXCR5 receptors are expressed on mature, recirculating B-LYMPHOCYTES and are specific for CHEMOKINE CXCL13.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
The name of two islands of the West Indies, separated by a narrow channel. Their capital is Basse-Terre. They were discovered by Columbus in 1493, occupied by the French in 1635, held by the British at various times between 1759 and 1813, transferred to Sweden in 1813, and restored to France in 1816. Its status was changed from colony to a French overseas department in 1946. Columbus named it in honor of the monastery of Santa Maria de Guadalupe in Spain. (From Webster's New Geographical Dictionary, 1988, p470 & Room, Brewer's Dictionary of Names, 1992, p221)
BEETLES in the family Curculionidae and the largest family in the order COLEOPTERA. They have a markedly convex shape and many are considered pests.
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.
An agricultural fungicide and seed treatment agent.
An organochlorine compound that was formerly used as an insecticide. Its manufacture and use has been discontinued in the United States. (From Merck Index, 11th ed)
A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)
A man-made compound previously used to control termites and other insects. Even though production of heptachlor was phased out of use in the United States during the late 1980's it remains in soil and hazardous waste sites. It is clearly toxic to animals and humans but, the International Agency for Research on Cancer (IARC) has determined that heptachlor is not classifiable as to its carcinogenicity to humans. (From ATSDR Public Heath Statement, April 1989)
One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.
One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.

Susceptibility to chlordecone-carbon tetrachloride induced hepatotoxicity and lethality is both age and sex dependent. (1/39)

The present paper examines the susceptibility to chlordecone (Kepone, CD) and carbon tetrachloride across different ages (35, 45, and 63-days-old) in male and female Sprague-Dawley rats using different lengths of time on a CD diet (10 ppm). The principal findings are that the hepatotoxicity and mortality associated with CD-CCl4 interaction is highly age-dependent for both sexes. There was marked hepatotoxicity occurring in both sexes as they reached 45 days-of-age and females were considerably more susceptible than males to both CD-CCl4-induced hepatotoxicity and lethality. While 63-day-old females are more susceptible to the CD-CCl4 interaction than their male counterparts, the magnitude of the sex difference is diminished from that observed in 45-day-old rats. These findings challenge the hypothesis of Mehendale (1990, Med. Hypotheses 33, 289-299) that chlordecone (CD) pretreatment eliminates the well-established sex difference in CCl4-treated rats. In contrast to the CD-CCl4 findings, the sex difference in CCl4-induced hepatotoxicity was not age-dependent and was consistent over the three ages studied. The findings that CD-CCl4 interaction is highly age-dependent (within the 3 ages tested) but that CCl4-induced hepatotoxicity is not, suggest that the CD-CCl4 interaction acts via a mechanism that does not primarily involve CCl4 potentiation.  (+info)

Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. (2/39)

In order to produce a reporter gene assay for androgenic chemicals, a constitutive expression vector coding for the human androgen receptor and a reporter construct containing the firefly luciferase coding sequence under transcriptional control of the androgen responsive MMTV promoter were cotransfected into the androgen-insensitive human PC-3 prostate carcinoma cell line and stable transfectants selected. One colony of transfectants, PC-3 LUCAR+, was characterized further. 5alpha-Dihydrotestosterone (DHT) enhanced luciferase activity in a linear fashion for up to 3 days of culture. The Kd for DHT activation was within the range of 25.0-60.0 pM (r2 values >0.95). Flutamide competitively inhibited DHT activation (mean Ki value of 0.89 microM). Progesterone, estradiol, dexamethasone, and hydrocortisone were weak agonists (100-fold less effective than DHT) and diethylstilbestrol was without effect. The effects of organochlorine food contaminants (0, 0.1, 1.0, and 10.0 microM) on luciferase activity in PC-3 LUCAR+ cells were determined after exposure to the chemical for 18 h in the presence and absence of DHT (50 pM). 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) induced luciferase activity in the absence of DHT (100 microM p,p'-DDE equivalent to 50 pM DHT), but in the presence of DHT (50 pM), p,p'-DDE acted antagonistically. 2,3,7,8-Tetrachlorodibenzo-p-dioxin, kepone, butylated hydroxyanisole, and butylated hydroxytoluene all partially inhibited activation by DHT (50 pM) but alone had little or no effect. Toxaphene at 10 microM induced luciferase activity in the absence of DHT but decreased cell viability. Alpha- and delta-Hexachlorocyclohexanes (HCH) at 10 microM antagonized the DHT effect, but beta-HCH and gamma-HCH mirex, photomirex, oxychlordane, cis- and trans-nonachlor were without effect. Thus, of the chemicals tested, some interact with the human androgen receptor in vitro as agonists, others as antagonists, and some as partial agonists/antagonists.  (+info)

Salmonid sexual development is not consistently altered by embryonic exposure to endocrine-active chemicals. (3/39)

Fish sexual development is sensitive to exogenous hormone manipulation, and salmonids have been used extensively as environmental sentinels and models for biomedical research. We simulated maternal transfer of contaminants by microinjecting rainbow trout (Oncorhynchus mykiss) and chinook salmon (Oncorhynchus tshawytscha) embryos. Fish were reared for 6 months and sexed, and gonads were removed for histology and measurement of in vitro steroid production. Analysis of fat samples showed that dichlorodiphenylethylene (DDE) levels, o, p'M-DDE and p,o, p'-DDE isomers, were elevated 6 months after treatment. A preliminary study showed an increased ratio of males to females after treatment with 80 mg/kg and 160 mg/kg of the xenoestrogen o,o, p'-DDE. One fish treated with 160 mg/kg o,o, p'-DDE had gonads with cells typical of both males and females. A follow-up study, using more fish and excluding the highly toxic 160 mg/kg o,o, p'-DDE dose, showed no effect on sex ratio or gonadal histology. Embryonic exposure of monosex male trout, monosex female trout, and mixed sex salmon to o, o, p'-DDE, p,o, p'-DDE, mixtures of DDE isomers, and octylphenol failed to alter sexual development. We observed no treatment-dependent changes in in vitro gonadal steroid production in any experiments. Trout exposed in ovo and reared to maturity spawned successfully. These results suggest that mortality attributable to the xenoestrogens o,o, p'-DDE, chlordecone, and octylphenol, and the antiandrogen p,o, p'-DDE, is likely to occur before the appearance of subtle changes in sexual development. Because trout appeared to be sensitive to endocrine disruption, we cannot dismiss the threat of heavily contaminated sites or complex mixtures to normal sexual development of salmonids or other aquatic organisms.  (+info)

Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. (4/39)

Although benign, uterine leiomyomas occur with high frequency and significant morbidity in reproductive-age women, and they present a significant health problem. Leiomyomas develop in the uterine myometrium and are sensitive to ovarian hormones, making them potential target sites for endocrine disruptors. Here we utilize cell lines derived from rat uterine leiomyomas to determine if a panel of 7 organochlorine pesticides have potential agonist activity in myometrial cells using cellular and molecular in vitro assays. The organochlorine pesticides investigated have been previously characterized as having agonist activity in other hormonally responsive tissues, but their effects have not been studied in uterine myometrial cells. In Eker rat leiomyoma-derived cells, HPTE, kepone, and the alpha isomer of endosulfan stimulated proliferation, an effect dampened by the antiestrogen ICI 182,780. In addition, these compounds stimulated transcription of the vitellogenin estrogen-response element via the ER in a transcriptional reporter gene assay and induced the expression of an endogenous estrogen-responsive gene, the progesterone receptor (PR). This contrasted with the agonist profile of methoxychlor, dieldrin, toxaphene, and endosulfan-beta. These compounds, unable to stimulate proliferation of uterine leiomyoma cells, did exhibit agonistic activity in these cells at the transcriptional level in the estrogen-sensitive reporter gene assay, and they were also able to upregulate PR message. These data demonstrate that organochlorine pesticides act as estrogen receptor agonists in Eker rat uterine myometrial cells, and they indicate a need for further investigation of the potential tissue-specific agonist activity of these pesticides and their role in the pathogenesis of uterine leiomyoma.  (+info)

Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. (5/39)

Methoxychlor (MXC) is currently used to protect agricultural products from insects. Previous studies show that MXC adversely affects the ovary, but the target cells were not revealed by those studies. Therefore, the purpose of this study was to test the hypothesis that MXC induces ovarian changes by adversely affecting the antral follicles and the ovarian surface epithelium in the mouse. To test this hypothesis, cycling female CD-1 mice (39 days) were dosed with MXC (8, 16, or 32 mg/kg/day), kepone (KPN, 8 mg/kg/day, positive control), or sesame oil (vehicle control) via intraperitoneal injection for 10 or 20 days. Estrous cyclicity was evaluated daily via vaginal lavage. After dosing, ovaries were collected for histological evaluation of follicle numbers, atresia, and surface epithelial height. The results indicate that at the 20-day time point, MXC (32 mg/kg) and KPN (8 mg/kg) increased the percentage of atretic antral follicles (n= 4-9,p+info)

17beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice. (6/39)

Mirex, an organochlorine pesticide, is a potent non-phorbol ester tumor promoter in mouse skin. Previous studies have shown that female mice are 3 times more sensitive to mirex tumor promotion than male mice and that ovariectomized (OVX) female mice are resistant to mirex promotion, suggesting a role for ovarian hormones in mirex promotion. To determine whether the ovarian hormone 17-beta estradiol (E2) is responsible for the sensitivity of female mice to mirex promotion, female mice were initiated with DMBA; 2 weeks later groups of mice were OVX and implants, with or without E2, were surgically implanted subcutaneously. These mice were treated topically twice weekly with mirex for 26 weeks. E2 implanted OVX mice demonstrated high normal physiologic levels of serum E2 throughout the tumor promotion experiment. E2 implants restored by 80% the intact mirex-sensitive phenotype to the OVX mice. Consistent with a role for E2 and ERalpha and ERbeta, treatment of DMBA-initiated female mice with topical ICI 182,780, an estrogen-receptor antagonist, reduced mirex tumor multiplicity by 30%. However, in cells co-transfected with ERalpha or ERbeta and estrogen-responsive promoter reporter, mirex did not stimulate promoter reporter activity, suggesting that the promotion effect of mirex is downstream of ERalpha/beta. Finally, a tumor promotion study was conducted to determine whether E2 implants could increase the sensitivity of male mice to mirex promotion. E2 implants in male mice did increase sensitivity to mirex promotion; however, the implants did not produce the full female sensitivity to mirex tumor promotion. Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice.  (+info)

Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats. (7/39)

Our earlier histomorphometric and biochemical studies suggested that the progressive phase of the interactive toxicity of chlordecone (CD) + CCl4 involves suppression of hepatocellular regeneration. The objective of the present work was to correlate hepatocellular regeneration with CCl4 (100 microliters/kg)-induced hepatotoxicity in rats maintained for 15 days on a normal (N) diet, relative to the regenerative response in rats maintained on a diet containing either 10 ppm CD, 225 ppm phenobarbital (PB), or 10 ppm mirex (M). Hepatocellular regeneration was assessed by measuring DNA and 3H-thymidine (3H-T) incorporation, followed by autoradiographic analysis of liver sections. Hepatotoxicity was assessed by measuring plasma transaminases (aspartate and alanine) followed by histopathological observations of liver sections for necrotic, swollen, and lipid-laden cells. Lethality studies were also carried out to assess the consequence of hepatotoxicity on animal survival. Dietary 10 ppm CD potentiated the hepatotoxicity of CCl4 to a greater extent than PB or M, as evidenced by elevations in plasma enzymes. Although the serum enzymes were significantly elevated in PB rats in contrast to the slight elevations in N and M rats, they returned to normal levels by 96 hr. However, serum enzyme elevations in CD rats were progressive with time until death of the animals. Actual liver injury by CCl4 was greater in PB- than in CD-pretreated rats, as evidenced by histopathological observations. A 100% mortality occurred in CD-pretreated rats at 60 hr after CCl4 administration, whereas no mortality occurred in either N-, M-, or PB-pretreated rats, indicating recovery from liver injury. Hepatocellular nuclear DNA levels were significantly decreased starting at 6 hr after CCl4 administration to CD-pretreated rats, but not in M- or PB-pretreated rats. 3H-T incorporation into nuclear DNA as well as percentage of labeled cells showed a biphasic increase in N rats: 1 at 1-2 hr, and the other at 36-48 hr after CCl4 administration. However, only 1 peak of 3H-T incorporation at 36-48 hr was observed in the CD + CCl4 combination, which was also significantly lower when compared to that observed after the M or PB + CCl4 combination treatments. These findings suggest that there is recovery in N-, PB-, or M-pretreated rats from CCl4-induced injury by virtue of the stimulated hepatocellular regeneration and tissue repair.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice. (8/39)

Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects women more frequently than men. In the (NZB times NZW)F1 mouse, a murine SLE model, the presence or absence of estrogen markedly influences the rate of progression of disease. Three organochlorine pesticides with estrogenic effects were administered chronically to ovariectomized female (NZB times NZW)F1 mice, and we measured the time to development of renal disease, the principal clinical manifestation of lupus in this model. Treatment with chlordecone, methoxychlor, or o,p -dichlorodiphenyltrichloroethane (o,p -DDT) significantly decreased the time to onset of renal impairment, as did treatment with 17ss-estradiol used as a positive control. In an expanded study of chlordecone, we found a dose-related early appearance of elevated anti-double-strand DNA autoantibody titers that corresponded with subsequent development of glomerulonephritis. Immunohistofluorescence confirmed early deposition of immune complexes in kidneys of mice treated with chlordecone. These observations are consistent with an effect of these organochlorine pesticides to accelerate the natural course of SLE in the (NZB times NZW)F1 mouse. Although we originally hypothesized that the effect on progression of autoimmunity was due to estrogenic properties of the pesticides, autoimmune effects and estrogenicity, assessed through measurement of uterine hypertrophy, were not well correlated. This may indicate that uterine hypertrophy is a poor indicator of comparative estrogenic effects of organochlorine pesticides on the immune system, or that the pesticides are influencing autoimmunity through a mode of action unrelated to their estrogenicity.  (+info)

Chlordecone is a pesticide used in theAntillesfor more than 20 years to combat banana weevil. However, its widespread use (prohibited in theAntillesfrom 1993) and persistence in the environment have caused permanent soil pollution and contamination of the population. Chlordecone is now considered to be an endocrine disruptor and a neurotoxin, and is classified by the WHO as potentially carcinogenic to humans.. To evaluate the impact on health of exposure to chlordecone, the team led by Sylvaine Cordier in Rennes and Luc Multigner in Pointe à Pitre set up a large mother and child cohort in Guadeloupe, known as TIMOUN[1] (meaning child in Creole). The general aim of the study is to evaluate the health impact of chlordecone exposure on pregnancy and on pre- and post-natal development. The cohort consisted of 1042 women, who were monitored with their children from their pregnancy during the period 2005-2007. Researchers were particularly interested in the impact of pre-natal and post-natal ...
The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. Human bile obtained from chlordecone-poisoned factory workers contained substantial amounts of free chlordecone, but little free chlordecone alcohol. However, when the same bile specimens were pretreated with beta-glucuronidase before analysis by gas-liquid chromatography, large amounts of chlordecone alcohol appeared, accounting for 75% of total organochlorine compounds. Confirmation of the identity of chlordecone and chlordecone alcohol was made by using gas liquid chromatography-mass spectrometry. Whereas biliary chlordecone alcohol was present predominantly as its glucuronide conjugate (93%), chlordecone was excreted primarily as the unaltered compound (72%) with only a small portion conjugated with glucuronic acid (9%). The remaining fraction of the total chlordecone measured in bile appeared to be a stable polar metabolite resistant to beta-glucuronidase. This unidentified ...
Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). In rodents, hepatic basolateral SR-BI is important in controlling plasma lipoprotein levels and cholesterol (CH) homeostasis, with major roles in reverse CH transport (RCT) and biliary excretion. The hepatic ABCG5/G8 heterodimer is a membrane transporter present on the apical surfaces of hepatocytes, and also plays a key role in biliary CH ...
Technical grade kelevan contains 94 - 98% pure kelevan, 0.1 - 2% chlordecone, and 0.5 - 4.0% inorganic salts (Maier-Bode, 1976). 2.2. Physical and Chemical Properties The technical material is a brownish substance. Some physical and chemical properties of kelevan are given in Table 1. 2.3. Analytical Methods Kelevan can be extracted from plant or animal tissues, or soils using methylene chloride, isopropanol, or acetone. It can be oxidized by refluxing with chromium trioxide in glacial acetic acid to yield chlordecone. The chlordecone is then determined by gas- liquid chromatography (GLC) techniques (Westlake et al., 1970). An analytical method using liquid chromatography/mass spectrometry has been described by Cairns et al. (1982). Table 1. Some physical and chemical properties of kelevan --------------------------------------------------------------------------- Physical state solid, powder Colour white Relative molecular mass 634.79 Melting point 91 C Vapour pressure (20 C) , 0.0014 Pa (= , ...
The oncogenotype of a tumor can promote a specific mechanism of chemoresistance that can contribute to the survival of hepatic CSCs. Under circumstances that promote differentiation of CSCs into more mature tumor cells, the chemoresistance can be quickly lost. Elucidation of the mechanisms that gove …
Any evaluation of toxicity to reproduction will have as an important consideration that events may not only be on the adults having impact on their likelihood to have children, but also impact the viability and quality of life of their potential offspring and feasibly even affect later generations. That chemicals can adversely affect reproduction in males and females is not a new concept, one only has to look at the importance of drugs as contraceptives to realize how sensitive the reproductive system can be to external chemical influences to disrupt this process. Of course in these cases, the failure of normal reproduction is a desired outcome in a contraceptive, but unfortunately we have had a number of catastrophes in which such failure has been unintentional. Many of the classic examples in chemical workers, or contamination of groundwater from chemical exposure such as dibromochloropropane (DBCP) or kepone (chlordecone) have shown the sensitivity of human reproduction to these specific ...
We utilized milk samples obtained from a survey of 219 primiparous mothers in 2009 to test for the presence of new persistent organic pollutants: hexachlorocyclohexane (HCH), pentachlorobenzene (PeCB), chlordecone, polybrominated biphenyls (PBBs), polybrominated diphenyl ethers (PBDEs), and perfluorinated compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctane sulfonyl fluoride (PFOS-F), and perflurooctanoic acid (PFOA). 158 samples were pooled according to the mothers age, length of stay in Hong Kong, and their dietary habits (frequencies of intake of fish and other seafood, and milk and dairy products) and tested for chlordecone, PBDEs, PBBs and PFCs. All were present in our samples. Their mean and median concentrations are very high compared to findings in other countries. HCH and PeCB were tested in 73 individual samples and their mean levels were of the same order of magnitude as those reported in our previous study. The levels of PBDEs were positively associated ...
Chlorella can be taken with at least one glass of any Chlorella Powder Uk Havaiana Quanto Custa liquid per 15 tablets. 8 Bottles Spirulina 500mg x 8800 caps in total Save. Chlorella Powder Uk Havaiana Quanto Custa well spirulina is considered a superfood because of its nutrient dense content. Chlorella and spirulina combined provide an incredible variety of nutrients.. T Chloramines Chloramphenicol Chlorates chlordecone reductase Chlorella virus DNA ligase chlorethylclonidine chlorfenethol Chlorhexidine chlorhexidine gluconate Chloride Channels Friday 7 December 2007. Spirulina este foarte bogata in proteine: in 100 g de spirulina se gasesc 60-70 g de celule Exista mai multe specii de spirulina. Including whole foods like chlorella in your diet is one step you can take toward reducing your risks for cancer.. Pure Organic Chlorella (Certified Organic) tablets and powder from blue-green yaeyama pacifica chlorella 500 tablets take during is safe pregnancy algae contains essential amino acids ...
Hepatoprotective action: The natural ingredients in Liv.52 DS exhibit potent hepatoprotective properties against chemically-induced hepatotoxicity. It restores the functional efficiency of the liver by protecting the hepatic parenchyma and promoting hepatocellular regeneration. The antiperoxidative activity of Liv.52 DS prevents the loss of functional integrity of the cell membrane, maintains cytochrome P-450 (a large and diverse group of enzymes, which catalyze the oxidation of organic substances), hastens the recovery period and ensures early restoration of hepatic functions in infective hepatitis. It facilitates the rapid elimination of acetaldehyde (produced by the oxidation of ethanol that is popularly believed to cause hangovers) and ensures protection from alcohol-induced hepatic damage. Liv.52 DS also diminishes the lipotropic (compounds that help catalyze the breakdown of fat) effect in chronic alcoholism and prevents fatty infiltration of the liver. In pre-cirrhotic conditions, Liv.52 ...
Childrens body mass is so much lower than adults', toxicity testing fails to adequately take into account the negative effects of pesticides on children.
TY - JOUR. T1 - The effect of pesticides on the function of the nervous system. AU - Dési, I.. PY - 1981. Y1 - 1981. UR - http://www.scopus.com/inward/record.url?scp=0019523384&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019523384&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0019523384. VL - 12. JO - Vascular Pharmacology. JF - Vascular Pharmacology. SN - 1537-1891. IS - 2. ER - ...
methoxychlor definition: A white crystalline mixture, Cl3CCH(C6H4OCH3)2, made use of as an insecticide.; A synthetic organochlorine used as an insecticide.
Alkanes C10-C13, chloro (short-chain chlorinated paraffins) (SCCPs): 10 000 mg/kg;. Aldrin: 5 000 mg/kg;. Chlordane: 5 000 mg/kg;. Chlordecone: 5 000 mg/kg;. DDT (1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane): 5 000 mg/kg;. Dieldrin: 5 000 mg/kg;. Endosulfan: 5 000 mg/kg;. Endrin: 5 000 mg/kg;. Heptachlor: 5 000 mg/kg;. Hexabromobiphenyl: 5 000 mg/kg;. Hexachlorobenzene: 5 000 mg/kg;. Hexachlorobutadiene: 1 000 mg/kg;. Hexachlorocyclohexanes, including lindane: 5 000 mg/kg;. Mirex: 5 000 mg/kg;. Pentachlorobenzene: 5 000 mg/kg;. Perfluorooctane sulfonic acid and its derivatives (PFOS). (C8F17SO2X). (X = OH, Metal salt (O-M+), halide, amide, and other derivatives including polymers): 50 mg/kg;. Polychlorinated Biphenyls (PCB) (3): 50 mg/kg;. Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDF) (4): 5 mg/kg;. Polychlorinated naphthalenes*: 1 000 mg/kg;. Sum of the concentrations of tetrabromodiphenyl ether C12H6Br4O), pentabromodiphenyl ether (C12H5Br5O), hexabromodiphenyl ether ...
en] Sea turtles including the green turtle Chelonia mydas and the hawksbill turtle Eretmochelys imbricata are critically endangered species, facing different factors as marine pollution. There is a blatant lack of data dealing with toxicants such as metals and persistent organic pollutants (POPs) in sea turtles. We developed a strategy to apprehend levels, effects and transfer to offspring of several pollutants in sea turtles. Sampling of blood, subcutaneous tissue and eggs of 15 gravid C. mydas and E. imbricata was carried out between July and September 2008 in Martinique (Diamants beach) and Guadeloupe (Petite Terre and Marie-Galante). Blood was collected from the dorso-cervical sinus and subcutaneous tissue was sampled in shoulder of the spawning females using a 5 mm biopsy punch (Kai Europe GmbH, Germany). Total blood and serum were successfully taken for metal, POP and biomarker investigations. T-mercury was analyzed by DMA milestones while PCBs, DDT and chlordecone were analyzed by EDC ...
Devault, Damien A. and Laplanche, Christophe and Pascaline, Hélène and Bristeau, Sébastien and Mouvet, Christophe and Macarie, Hervé Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants. (2016) Environmental Science and Pollution Research, vol. 23 (n° 1). pp. 81-97. ISSN 0944-1344 Dejean, Alain and Revel, Messika and Azémar, Frédéric and Roux, Olivier Altruism during predation in an assassin bug. (2013) Naturwissenschaften, vol. 100 (n° 10). pp. 913-922. ISSN 0028-1042 Mansot, Jean-Louis and Delbé, Karl and Baranek, Philippe and Thomas, Philippe and Boucher, Florent and Vangelisti, Rene and Billaud, Denis Experimental and theoretical investigations of friction properties of graphite intercalated compounds. (2013) In: 40th Leeds-Lyon Symposium on Tribology & Tribochemistry Forum 2013, 4 September 2013 - 6 September 2013 (Lyon, France). Thomas, Philippe and Mansot, ...
Usage of Liv.52 (LiverCare ) can help regulate levels of enzymes and optimize assimilation and improve the functional efficiency of the liver. Liv.52 (LiverCare) helps restore the functional efficiency of the liver by protecting the hepatic parenchyma and assist in promoting hepatocellular regeneration. It facilitates rapid elimination of acetaldehyde, the toxic intermediate metabolite of alcohol metabolism, and helps ensure protection from alcohol-induced hepatic damage. Liv.52
Usage of Liv.52 (LiverCare ) can help regulate levels of enzymes and optimize assimilation and improve the functional efficiency of the liver. Liv.52 (LiverCare) helps restore the functional efficiency of the liver by protecting the hepatic parenchyma and assist in promoting hepatocellular regeneration. It facilitates rapid elimination of acetaldehyde, the toxic intermediate metabolite of alcohol metabolism, and helps ensure protection from alcohol-induced hepatic damage. Liv.52
UC Davis toxicologist Carl Winter describes cases when pesticides actually increase the healthfulness of foods by reducing the levels of naturally occurring toxins produced by the plants or fungi on the plants.
DOI: 10.1021/acs.est.0c03575. The Global Monitoring Plan of the Stockholm Convention on Persistent Organic Pollutants (POPs) was established to generate long-term data necessary for evaluating the effectiveness of regulatory measures at a global scale. After a decade of passive air monitoring (2008-2019), MONET is the first network to produce sufficient data for the analysis of long-term temporal trends of POPs in the African atmosphere. This study reports concentrations of 20 POPs (aldrin, chlordane, chlordecone, DDT, dieldrin, endrin, endosulfan, HBCDD, HCB, HCHs, heptachlor, hexabromobiphenyl, mirex, PBDEs, PCBs, PCDDs, PCDFs, PeCB, PFOA, and PFOS) monitored in 9 countries (Congo, Ghana, Ethiopia, Kenya, Mali, Mauritius, Morocco, Nigeria, and Sudan). As of January 1, 2019, concentrations were in the following ranges (pg/m3): 0.5-37.7 (∑6PCB), 0.006-0.724 (∑17PCDD/F), 0.05-5.5 (∑9PBDE), 0.6-11.3 (BDE 209), 0.1-1.8 (∑3HBCDD), 1.8-138 (∑6DDT), 0.1-24.3 (∑3endosulfan), 0.6-14.6 ...
Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression Roberts, Matthew A; Berger, Alvin; Bruce German, J; Mutch, David M ...
DArcy Thompson Zoology Museum Dundee City Council Changing for the Future http://www.dundee.com/events/talk-dr-christopher-connolly.html ...
New tests found significant decreases in the use of bee-killing pesticides on bee-friendly plants. Thats good news for bees.
Segmentino is a Vamp plugin for automatic music structural segmentation, based on an algorithm first used in Mauch et al.s paper on Using Musical Structure to Enhance Automatic Chord Transcription. Version 1.0 was run in MIREX 2013 (results here).. ...
In 2002, Susan Schmidt retraced John Smiths 1608 voyage on the Chesapeake Bay. In Landfall along the Chesapeake, a cruising guide for Chesapeake boaters and a field log for naturalists, Schmidt compares the beauty of ancestral legacy and childhood memory to her observations on a 100-day voyage in a 22-foot boat. As she circles the Bay counterclockwise from Jamestown, she explores Smiths encounters with Native Americans and the Bays ecological changes over the past four hundred years. On each river and creek, she quotes Smiths journals on matching wits with Powhatan, meeting Pocahontas, surviving thunderstorms, ambush, and a stingrays barb. Anchored on wild creeks, Schmidt observes swans and dragonflies, lightning and sunsets; in port she interviews colorful characters and working watermen about blue crabs and oysters. Scientists explain the Bays nitrogen overload, water-level rise, anoxia, Pfiesteria, Kepone, and the Ghost Fleet. Native American chiefs discuss their heritage then and now. ...
This application note from Cecil Instruments describes an effective method for organochlorine pesticide analysis in the environment by reversed phase chromatography with UV-Vis detection. The method was performed using the Adept HPLC Series System 2. The experimental conditions and subsequent results are presented.
Hepatic cirrhosis results from fibrous scarring mixed with hepatocellular regeneration in response to sustained inflammatory, toxic, metabolic, and congestive
Story at-a-glance The European Parliament recently commissioned a report outlining the benefits of organic food and farming techniques over conventionally grown food, usually grown using pesticides on crops Conventional farming operations commonly use pesticides on the foods they produce hoping for greater yields, faster, but the report revealed pesticides are toxic to humans and particularly…
Use of pesticides continues to be indiscriminate, and birds are one of the worst affected non-targeted organisms. Information on the ill effects of pesticides on birds far from desired in India. Despite the presence of a wide variety and number of birds, there is exceedingly little data on organochlorine pesticide (OCP) residues in colonial nesting birds in sanctuaries of India. A total of 76 indi ...
This is a rarer form of acne. This type of acne stems from being exposed to motor oil or pesticides on a continual basis. If you have this type of acne then you should have the rest of your health checked as you may have been exposed to harmful pollutants. The only way to reduce this type of acne is to minimize or eliminate your exposure to motor oil and pesticides ...
| Pesticides are some of the most harmful substances found in our environment today. The primary function of these chemicals is to eradicate unwanted
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
HPLC Application #18282: Carbamate Pesticides on Kinetex 2.6µm C18 50 x 4.6mm ID. Column used: Kinetex® 2.6 µm C18 100 Å, LC Column 50 x 4.6 mm, Ea Part#: 00B-4462-E0
In so many ways, gardening is a very beneficial activity, not only for the environment, but for those who partake in this exercise. After properly reading the instructions, this man was in the process of applying pesticide spray to his raised-bed home garden. - Free Stock Photo Id: 16078 (2.2 MB)
One can only hope. I wonder if mrgybe will ever try to make a point without insults, belittling those who disagree with him, or outright slander? By the numbers. While mrgybe knows much about efforts for malaria control in Africa, and is willing to share it in little bits and pieces, sprinkled with insults, he doesnt know much about contaminant chemistry, or DDT toxicity, and doesnt appear to be much interested in learning. His approach throughout his responses has been to start with slander and insults, and gradually evolve his story with either more information or minor corrections when his misstatements are pointed out. He has finally evolved a position which is clear, although it still has two logic leaps in it: he is angry that the banning of DDT in this country led to a limitation in aid for malaria control with DDT. The three problems with that position are 1) he ignores or belittles the opinions of others that DDT should only be used as a last resort; 2) he ignores the availability of ...
One can only hope. I wonder if mrgybe will ever try to make a point without insults, belittling those who disagree with him, or outright slander? By the numbers. While mrgybe knows much about efforts for malaria control in Africa, and is willing to share it in little bits and pieces, sprinkled with insults, he doesnt know much about contaminant chemistry, or DDT toxicity, and doesnt appear to be much interested in learning. His approach throughout his responses has been to start with slander and insults, and gradually evolve his story with either more information or minor corrections when his misstatements are pointed out. He has finally evolved a position which is clear, although it still has two logic leaps in it: he is angry that the banning of DDT in this country led to a limitation in aid for malaria control with DDT. The three problems with that position are 1) he ignores or belittles the opinions of others that DDT should only be used as a last resort; 2) he ignores the availability of ...
Wheeler, W. B., D. P. Jouvenaz, D. P. Wojcik, W. A. Banks, C. H. Van Middelem, C. S. Lofgren, S. Nesbitt, L. Williams, and R. Brown. 1977. Mirex residues in nontarget organisms after application of 10-5 bait for fire ant control, northeast Florida--1972-74. Pestic. Monit. J. 11: 146-156. Wojcik, D. P., W. A. Banks, W. B. Wheeler, D. P. Jouvenaz, C. H. Van Middelem, and C. S. Lofgren. 1975. Mirex residues in nontarget organisms after application of experimental baits for fire ant control, Southwest Georgia--1971-72. Pestic. Monit. J. 9: 124-133, 1976. Errata 10: 31. ...
A YEAR ago, the farming industry was up in arms over proposed regulations aimed at preventing pollution. As then worded by the Scottish Government, the regulations would have prohibited any spreading of fertiliser or pesticide on slopes above 12 degrees, taking a fair percentage of land in Scotland out of production.
These natural and DIY pesticides are effective at helping to rid your crops of harmful critters, but safe enough to keep from poisoning you and your family.
Pesticides are something quite common in the nowadays agriculture, as most of the farmers use them to spray their crops, with a very powerful purpose - to prevent the damage produced by pests. Besides their advantages, pesticides also have a great disadvantage - they can harm your system to the …. Read More » ...
1] D. Pimentel, Amounts of pesticides reaching target pests: Environmental impacts and ethics, Journal of Agricultural and Environmental Ethics, vol. 8, no. 1, pp.17-29, 1995. Doi: http://dx.doi.org/10.1007/bf02286399. [2] W. B. Bollen, Interactions between pesticides and soil microorganisms, Annual Review of Microbiology, vol. 15, no. 1, pp. 69-92, 1961. Doi: http://dx.doi.org/10.1146/annurev.mi.15.100161.000441. [3] C. M. Tu, Effects of pesticides on activities of enzymes and microorganisms in a clay soil, Journal of Environmental Science and Health, Part B, vol. 16, no. 2, pp. 179-191, Jan. 1981. Doi: http://dx.doi.org/10.1080/03601238109372250. [4] G. Imfeld and S. Vuilleumier, Measuring the effects of pesticides on bacterial communities in soil: A critical review, European Journal of Soil Biology, vol. 49, pp. 22-30, 2012. Doi: http://dx.doi.org/10.1016/j.ejsobi.2011.11.010. [5] M. Cycoń and Z. Piotrowska-Seget, Biochemical and microbial soil functioning after application of the ...
Alif SM, Dharmage SC, Benke G, Dennekamp M, Burgess JA, Perret JL, Lodge CJ, Morrison S, Johns DP, Giles GG, Gurrin LC, Thomas PS, Hopper JL, Wood-Baker R, Thompson BR, Feather IH, Vermeulen R, Kromhout H, Walters EH, Abramson MJ, Matheson MC. Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age. THORAX 72 (11) : 990 - 997(2017) PubMed ...
Article Ascentis™ RP-Amide for the Analysis of Pesticides. Application Report 209 Analysis of the Pesticides Carbaryl, Diuron, and Propachlor Using Ascentis™ RP-Amide This application demonstrates the suitability of the Ascentis RP-Amide for ...
Thus, had we merely conducted simple tests of statistical significance, we could correctly have said that the results were not statistically significant in most cases; given the number of simultaneous tests that we had conducted, the few significant exceptions could be discounted. While correct, such statements commonly lead readers of papers (and not infrequently the authors themselves) to conclude that despite an investigation aimed at uncovering evidence there is no evidence for an effect. Authors and readers may then go on to conclude that the lack of evidence indicates that there is no effect. In this respect, Pilling et al. [5] were correct to assert that given that formal analysis of their data would lack the power to detect anything other than very large treatment effects, a formal analysis would be potentially misleading.. However, we argue that naïve hypothesis tests are inadequate in cases such as studying the impact of thiamethoxam on honeybees, where we need to know the ...
Non-polar HP-PAS5 columns specifically designed and processed for the analysis of organochlorine pesticides. With an operating temperature range of -60...
Ive tried a lot of different things in my journey through the crazy world of health and wellness. Its hard to capture all of them in my 10 Steps, so here are 10 specific things that I believe were game-changers in my success:. 1. I learned how to relax and enjoy life in the least relaxing situation ever. Not easy, but until I figured this out, the rest was just slapping Band-Aids on a seeping wound. Life is risk, were all here to learn, and I reached out for help when I needed it. Find what works for you to neutralize emotional chaos.. 2. I juice vegetables, not fruits. I want to EAT my fruits to get all the good fiber they bring to the table. Fiber also helps slow down my bodys absorption of fructose, so I can avoid insulin spikes.. In contrast, vegetables usually pack less fructose and more anti-cancer nutrients into every square centimeter, so I juice them to make that goodness even more concentrated. (Note: I only juice organic vegetables, which have less pesticide on them. Why would I ...
POTATOES that have been genetically engineered to commit suicide if they are infected by disease could reduce the need to use pesticides on potato crops. If the potatoes are attacked by fungi the infected cells destroy themselves to avoid spreading the disease. Barnase is an enzyme that destroys ribonucleic acids leading to a fatal halt …
Antibiotics like Cipro works best when there is a constant amount in the blood and urine. Hence, you must ensure that you do not miss any dose. If you miss a dose of Cipro, then take it if there is ample time before your second dose. But if it is nearly time for the next dose, then skip the missed dose and continue with your regular schedule. Do not take a double dose ever ...
The liver is the major site of clearance and degradation of foreign antigens from the portal circulation. Despite the presence of hepatic accessory cells, antibody responses to orally administered antigens are uncommon. To ascertain if hepatic accessory cells are incapable of stimulating specific subsets of T lymphocytes, freshly isolated hepatic nonparenchymal and splenic cells were cultured with a panel of antigen-specific, H-2-restricted Th1 and Th2 HTL clones. Whereas spleen cells stimulated the proliferation of both Th1 and Th2 clones, hepatic nonparenchymal cells (NPC) stimulated the proliferation of only Th1 and not Th2 clones. Adding rIL-1, rIL-6, and rIL-7, alone or in combination, to the cultures did not result in proliferation of the Th2 clones. Despite the absence of Th2 proliferation, NPC were able to stimulate the secretion of IL-3 and IL-4 by Th2 clones in the presence of antigen. Moreover, adding hepatic NPC did not inhibit spleen cells from stimulating Th2 clones in the presence ...
Breast cancer is a multifactorial disease and its etiology is linked to multiple risk factors. There are shreds of controversial evidence that exposure to organ...
Printing tips! To print chromatograms full page, change the print settings in the print dialogue window of your PDF reader software: 1) fit or fit to page, 2) landscape for wide chromatograms or portrait for tall chromatograms.. ...
If you care about what is in your food, you have no greater sympathetic intellect than me.But if you are an anti-science activist, you may not understand the distinction between what is in your food and what it simply is - and there we part company.
Women who live near California farm fields sprayed with organochlorine pesticides may be more likely to give birth to children with autism, according to a study by state health officials to be
At least one in every hundred cancers diagnosed each year in Europe may be directly related to pesticide exposure. The Sick of Pesticides (...)
The Centre for Science & Environment checks pesticide levels in blood from people of four Punjab villages and finds the levels of organochlorine pesticides shocking. Harjinder Sidhu reports.
Methoxychlor was tested by the oral route only in the rat. Three experiments, including one employing dietary levels of up to 1600 ppm (equivalent to about 80 mg/kg bw/day), provided no evidence of carcinogenicity. Because of inadequate reporting, conclusions cannot be drawn from the results of a fourth experiment in which some liver tumours were observed in rats fed up to 2000 ppm in the diet (equivalent to about 100 mg/kg bw/day). Data from these four experiments do not allow an evaluation of the carcinogenicity of methoxychlor to be made at the present time.. No tumours were reported in limited skin application and subcutaneous injection (single-dose) studies. ...
Loading up on fresh produce? If youre wondering which fruits and vegetables have the most and least pesticides on them, you may want to consult this years Dirty Dozen and Clean Fifteen list.
Synthetic Pesticides are chemical based that are usually are more effective than their organic counterparts, but many growers do prefer to stay on a more natural path unless they need to have more
As many of us know, we can find toxins and nasty chemicals in Virtually every thing. From the pesticides on our produce, towards the chemicals within our cosmetics, even our computers; its tough to appear by a little something fully chemical free. Every one of these chemicals and toxins are unveiled into our surroundings, traveling via our water, the air we breathe, are absorbed by human beings and wildlife with the food and h2o we consume, and thru our pores and skin. You are able tot see, touch, or odor numerous of such toxins. We typically do not come to feel their impacts right until/Unless of course we occur down by using a Persistent ailment immediately after decades of exposure. A report finished by Columbia College school of Public Wellness estimated that ninety five% of most cancers cases are a result of diet plan, and environmental toxicity ...
chlordecone reductase Ja 1.1.1.263 1,5-anhydro-D-fructose reductase Ja ...
Slow oxidation produces chlordecone ("Kepone"), a related insecticide that is also banned in most of the western world, but ... Mirex and chlordecone: health effects, toxicokinetics, human exposure, and environmental fate". Toxicology and Industrial ...
This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This ... "Entrez Gene: AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type ... and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization ... "Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase". Biochemistry. 29 (4): 1080-7. doi: ...
Chlordecone is toxic to aquatic organisms, and classified as a possible human carcinogen. Many countries have banned ... Additions to the initial 2001 Stockholm Convention list are as following POPs: Chlordecone, a synthetic chlorinated organic ... chlordecone sale and use, or intend to phase out stockpiles and wastes. α-Hexachlorocyclohexane (α-HCH) and β- ...
... and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization ... cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone ...
... chlordecone, methoxychlor, methylmercury, fenarimol, and TCDD. The Florida panther has low genetic diversity due to a variety ...
... and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization ...
... chlordecone and mirex at 0.06%, and dieldrin at 0.05%. Imidazole (a non-chloronated aromatic heterocyclic) at 1% also gave ...
Chlordecone, a pesticide used in the cultivation of bananas before a ban in 1993, has been found to have contaminated farming ...
... chlordecone) and DDT and its derivatives, the herbicide atrazine, and the fungicide vinclozolin), the contraceptive 17-alpha ...
... is cited amongst a handful of other noxious substances as the driver for Gerald Ford's half-hearted approval in ... Chlordecone, better known under the brand name Kepone in the United States, is an organochlorine compound and a colourless ... Chlordecone is a known persistent organic pollutant (POP) that was banned globally by the Stockholm Convention on Persistent ... In the US, chlordecone, commercialized under the brand name "Kepone", was produced by Allied Signal Company and LifeSciences ...
In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction chlordecone alcohol + ... NADP+ ⇌ {\displaystyle \rightleftharpoons } chlordecone + NADPH + H+ Thus, the two substrates of this enzyme are chlordecone ... The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR. As of ... Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. ...
Chlordecone. *Para-Chloroamphetamine. *Para-Chloromethamphetamine. *Chlorophenylsilatrane. *Cholinesterase inhibitor. * ...
... s are substances used to kill insects.[1] They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to be a major factor behind the increase in the 20th-century's agricultural productivity.[2] Nearly all insecticides have the potential to significantly alter ecosystems; many are toxic to humans and/or animals; some become concentrated as they spread along the food chain. Insecticides can be classified into two major groups: systemic insecticides, which have residual or long term activity; and contact insecticides, which have no residual activity. The mode of action describes how the pesticide kills or inactivates a pest. It provides another way of classifying insecticides. Mode of action can be important in understanding whether an insecticide will be toxic to unrelated species, such as fish, birds and mammals. Insecticides may be repellent or ...
Exposure to mirex and chlordecone occurs mainly from touching or eating soil or food that contains the chemicals. At high ... What happens to mirex and chlordecone when it enters the environment?. *Mirex and chlordecone break down slowly in the ... What is mirex and chlordecone?. Mirex and chlordecone are two separate, but chemically similar, manufactured insecticides that ... This fact sheet answers the most frequently asked health questions about mirex and chlordecone. For more information, you may ...
Toxicological Profile for Mirex and Chlordecone. Draft for Public Comment. Comments may be submitted via Regulations.gov. ... Toxicological profile for Mirex and Chlordecone (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human ... CAS#: Mirex 2385-85-5; Chlordecone 143-50-5 Toxicological Profile Information. The ATSDR toxicological profile succinctly ...
Chlordecone is cited amongst a handful of other noxious substances as the driver for Gerald Fords half-hearted approval in ... Chlordecone, better known under the brand name Kepone in the United States, is an organochlorine compound and a colourless ... Chlordecone is a known persistent organic pollutant (POP) that was banned globally by the Stockholm Convention on Persistent ... In the US, chlordecone, commercialized under the brand name "Kepone", was produced by Allied Signal Company and LifeSciences ...
In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction chlordecone alcohol + ... NADP+ ⇌ {\displaystyle \rightleftharpoons } chlordecone + NADPH + H+ Thus, the two substrates of this enzyme are chlordecone ... The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR. As of ... Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...
Chlordecone. Regulatory process names 5 Translated names 48 CAS names 1 IUPAC names 1 Other identifiers 5 ... chlordecone (ISO); perchloropentacyclo[5,3,0,02,6,03,9,0 4,8]decan-5-one; decachloropentacyclo[5,2,1,02,6,03,9,05,8]decan-4-one ...
Title: Toxicological Profile for Mirex and Chlordecone. Subject of Planned Report: Mirex and chlordecone are two separate ... Charge to Peer Reviewers: Charge to Peer Reviewers Mirex and Chlordecone. Peer Reviewers Comments and CDC/ATSDRs Response to ...
The analysis of the results by the researchers shows that chlordecone exposure is associated to a significant increase in the ... Final report on the evaluation of four toxic chemicals in an In Vivo/In Vitro toxicological screen -- acrylamide, chlordecone, ... One of the main objectives of the research programme was to test the hypothesis that chlordecone exposure favors the ... The prostate cancer risk associated with chlordecone exposure was higher in subjects with a family history of prostate cancer ...
Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio- ... Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio- ... More interestingly, disappearance of chlordecone (50 µg/mL) in two bacterial consortia was concomitant with the accumulation of ... More interestingly, disappearance of chlordecone (50 µg/mL) in two bacterial consortia was concomitant with the accumulation of ...
Results also showed that chlordecone was accumulated in cuticle, up to levels of 40% of the chlordecone body burden, which ... In addition, depuration in chlordecone-free water was studied. Results showed that chlordecone bioconcentration in prawns was ... probably due to successive spawning leading in the elimination of chlordecone through the eggs. Chlordecone distribution in ... Chlordecone is a persistent organochlorine pesticide that has been widely used in Guadeloupe (French West Indies) to control ...
Buy Chlordecone 10 µg/mL in Isooctane - CAS Number 143-50-0 from LGC Standards. Please login or register to view prices, check ... GC 1189 ; Clordecone ; 1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one, decachlorooctahydro- (6CI) ; NSC 56532 ; Chlordecone ; ...
In contrast to human bile, rat bile contained only trace amounts of chlordecone alcohol (less than 0.5% of total chlordecone), ... Whereas biliary chlordecone alcohol was present predominantly as its glucuronide conjugate (93%), chlordecone was excreted ... Confirmation of the identity of chlordecone and chlordecone alcohol was made by using gas liquid chromatography-mass ... Human bile obtained from chlordecone-poisoned factory workers contained substantial amounts of free chlordecone, but little ...
Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ... Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental ... chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was ...
HQ SERIAL Chlordecone : HQ SERIAL L approche fondâee sur la notion de risque et les soins de santâe : HQ SERIAL Endosulfan / ... Chlordecone : health and safety guide. Contributor(s): World Health Organization , International Programme on Chemical Safety ... 41 , Publisher: Geneva : World Health Organization, 1990Description: 24 p ISBN: 9241510412 Subject(s): Chlordecone -- standards ...
Chlordecone. Assessing the risks of chlordecone exposure in the French Caribbean. Updated on 13/07/2021 ... Keywords : Kepone, Chlordecone, Pesticides, Food contaminants, Chemical risks. Long used in the French Caribbean to control the ... The internal TRV was set at 0.4 µg of chlordecone per litre of plasma. This limit value is based on the observation that ... Chlordecone was used to combat weevils in the banana plantations of Martinique and Guadeloupe from 1972 to 1993. This pesticide ...
Impact of chlordecone exposure on the development of infants Press release , 17 Sep 2012 - 16h40 , By INSERM PRESS OFFICE ... Impact of chlordecone exposure on the development of infants. In an article published in the journal Environmental Research, ... Chlordecone is now considered to be an endocrine disruptor and a neurotoxin, and is classified by the WHO as potentially ... Chlordecone is a pesticide used in theAntillesfor more than 20 years to combat banana weevil. However, its widespread use ( ...
Available knowledges on mode of action and key-event hazards of chlordecone are used to identify effects of chlordecone that ... We develop methods for quantifying the health impacts of chlordecone and present the results in 2 articles: 1. hazard ... We derive ERFs for 3 possible effects at chronic low chlordecone dose: cancers, developmental impairment, and hepatotoxicity. ... Inhabitants of Guadeloupe are chronically exposed to low dose of chlordecone via local food. The corresponding health impacts ...
Chlordecone. Pesticide. Hexabromobiphenyl. Industrial Chemical. Hexabromodiphenyl ether and heptabromodiphenyl ether ( ...
Chlordecone. 143-50-0. PC8575000. Chlorinated camphene *. 8001-35-2. XW5250000. Chlorinated diphenyl oxide *. ...
At the fourth meeting of the Conference of the Parties to the Convention from 4 to 8 May 2009, it was agreed to add chlordecone ...
Chlordecone: 5 000 mg/kg;. DDT (1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane): 5 000 mg/kg; ...
chlordecone *hexabromobifenyl *lindane. The above pesticides have been banned in some countries and governments have officially ...
CHLORDECONE. (The trade name for chlordecone is Kepone) Commodity. Action Level (ppm). Reference. ... Chlordecone (Kepone). Dicofol (Kelthane). DDT, DDE, TDE. Dimethylnitrosamine (Nitrosodimethylamine). Ethylene Dibromide (EDB). ...
chlordecone reductase Ja 1.1.1.263 1,5-anhydro-D-fructose reductase Ja ...
Kepone (chlordecone). *Lead and lead compounds. *Lindane, hexachlorocyclohexane (technical grade), and other ...
Problem Substances : Chlordecone, Chlorinated Polycyclic Ketone, Pesticides. Adverse Pharmacological Actions : Carcinogenic, ...
pseudo-chlordecone reductase. testicular 17,20-desmolase deficiency. trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. type II ... chlordecone reductase homolog HAKRD. dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid ...
The present invention relates to the use of phosphated 2-propylheptanol, phosphated 2-proyplheptanol alkoxylate and/or mixtures thereof in agricultural formulations. The invention also relates to agri
  • Mirex was sold as a flame retardant under the trade name Dechlorane, and chlordecone was also known as Kepone. (cdc.gov)
  • Chlordecone, better known under the brand name Kepone in the United States, is an organochlorine compound and a colourless solid. (wikipedia.org)
  • In the US, chlordecone, commercialized under the brand name "Kepone", was produced by Allied Signal Company and LifeSciences Product Company in Hopewell, Virginia. (wikipedia.org)
  • The Dead Kennedys recorded a song named "Kepone Factory", a satire of the controversy surrounding Allied Signal and their negligence regarding employee safety, for their 1981 album In God We Trust, Inc.. Chlordecone is made by dimerizing hexachlorocyclopentadiene and hydrolyzing to a ketone. (wikipedia.org)
  • Analytical Research and Technology (University of Liège, Belgique), show that exposure to chlordecone (also named Kepone), an organochlorine chemical with well defined estrogenic properties used in the French West Indies until 1993, is associated to a significant increased risk of prostate cancer. (wordnik.com)
  • Chlordecone (Kepone ® ) is a synthetic organochlorine insecticide (C 10 Cl 10 O) used worldwide mostly during the 1970 and 1980s. (frontiersin.org)
  • Demonstration of major metabolic pathways for chlordecone (kepone) in humans. (aspetjournals.org)
  • The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. (genecards.org)
  • This group includes hexachlorocyclohexane, chlordecone (kepone) and pentachlorobenzene. (springer.com)
  • Definition : Kepone, also known as chlordecone, is an organochlorine compound and a colourless solid. (humpath.com)
  • In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction chlordecone alcohol + NADP+ ⇌ {\displaystyle \rightleftharpoons } chlordecone + NADPH + H+ Thus, the two substrates of this enzyme are chlordecone alcohol and NADP+, whereas its 3 products are chlordecone, NADPH, and H+. (wikipedia.org)
  • This fact sheet answers the most frequently asked health questions about mirex and chlordecone. (cdc.gov)
  • Exposure to mirex and chlordecone occurs mainly from touching or eating soil or food that contains the chemicals. (cdc.gov)
  • What is mirex and chlordecone? (cdc.gov)
  • Mirex and chlordecone are two separate, but chemically similar, manufactured insecticides that do not occur naturally in the environment. (cdc.gov)
  • Mirex and chlordecone have not been manufactured or used in the United States since 1978. (cdc.gov)
  • What happens to mirex and chlordecone when it enters the environment? (cdc.gov)
  • Mirex and chlordecone break down slowly in the environment, and they may stay for years in soil and water. (cdc.gov)
  • Mirex and chlordecone do not dissolve easily in water, but they easily stick to soil and sediment particles. (cdc.gov)
  • How might I be exposed to mirex and chlordecone? (cdc.gov)
  • How can mirex and chlordecone affect my health? (cdc.gov)
  • How likely are mirex and chlordecone to cause cancer? (cdc.gov)
  • The Department of Health and Human Services (DHHS) has determined that mirex and chlordecone may reasonably be anticipated to be carcinogens. (cdc.gov)
  • There are no studies available on whether mirex and chlordecone are carcinogenic in people. (cdc.gov)
  • However, studies in mice and rats have shown that ingesting mirex and chlordecone can cause liver, adrenal gland, and kidney tumors. (cdc.gov)
  • Is there a medical test to show whether I've been exposed to mirex and chlordecone? (cdc.gov)
  • 2019. Toxicological profile for Mirex and Chlordecone (Draft for Public Comment). (cdc.gov)
  • Mirex and chlordecone are two separate synthetic insecticides that have similar chemical structures. (cdc.gov)
  • A provisional MRL of 0.003 mg/kg/day has been derived for intermediate-duration oral exposure to chlordecone based on neurological effects from a 90-day oral study of male Sprague-Dawley rats (Linder et al. (cdc.gov)
  • One of the main objectives of the research programme was to test the hypothesis that chlordecone exposure favors the development of prostate cancer in the French West Indies. (wordnik.com)
  • The prostate cancer risk associated with chlordecone exposure was higher in subjects with a family history of prostate cancer first-degree relatives. (wordnik.com)
  • Moreover, the prostate cancer risk associated with chlordecone exposure was particularly marked in subjects who had spent some time living in a Western country. (wordnik.com)
  • These results are the first to suggest that there is a causal relationship between chlordecone exposure and prostate cancer risk, and support the hypothesis that environmental estrogens may be involved in the development of prostate cancer. (wordnik.com)
  • The analysis of the results by the researchers shows that chlordecone exposure is associated to a significant increase in the risk of prostate cancer with increasing plasma chlordecone concentration. (wordnik.com)
  • This study aimed at investigating the accumulation and tissue distribution of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii, using both laboratory (30 days exposure) and field (8 months exposure) approaches. (nih.gov)
  • Moreover, females appeared to be less contaminated than males after 5 and 7 months of exposure, probably due to successive spawning leading in the elimination of chlordecone through the eggs. (nih.gov)
  • Indeed, for a given person, the result of a single chlordecone blood level measurement provides no information on the source or duration of exposure. (anses.fr)
  • In view of the latest knowledge available on the risks associated with exposure to chlordecone, the ChlorExpo study on dietary exposure of the French Caribbean population to chlordecone was launched by ANSES in early 2021. (anses.fr)
  • Until these results become available, the Kannari study, set up in 2013 by ANSES, Santé Publique France and the regional health observatories with the support of the Martinique and Guadeloupe regional health agencies, identified the supply channels, production areas and populations most at risk of exposure to chlordecone. (anses.fr)
  • The results of this study show that pre- or post-natal exposure to chlordecone is associated with adverse effects on the cognitive and motor skills development of infants. (inserm.fr)
  • To evaluate the impact on health of exposure to chlordecone, the team led by Sylvaine Cordier in Rennes and Luc Multigner in Pointe à Pitre set up a large mother and child cohort in Guadeloupe, known as TIMOUN [1] (meaning 'child' in Creole). (inserm.fr)
  • The general aim of the study is to evaluate the health impact of chlordecone exposure on pregnancy and on pre- and post-natal development. (inserm.fr)
  • Researchers were particularly interested in the impact of pre-natal and post-natal exposure to chlordecone on the cognitive, visual and motor skills development of infants at the age of 7 months. (inserm.fr)
  • Pre-natal exposure to chlordecone was estimated from the levels in the umbilical cord blood. (inserm.fr)
  • Post-natal exposure was estimated from levels in the mother's breast milk and from the frequency of consumption by the infants of foodstuffs likely to be contaminated with chlordecone. (inserm.fr)
  • Pre-natal exposure to chlordecone was found to be associated significantly with a reduction in the score for visual preference for novelty [2] and a low score on the fine motor skills development scale [3] . (inserm.fr)
  • Post-natal exposure to chlordecone, estimated from the consumption of contaminated foodstuffs, was found to be associated, at the limit of statistical significance, with a reduction in the speed of acquiring visual memory and a reduction in visual preference for novelty. (inserm.fr)
  • However, post-natal exposure to chlordecone through breastfeeding does not appear to be associated with any change in psychomotor development. (inserm.fr)
  • In conclusion, pre-natal exposure to chlordecone or post-natal exposure via food consumption is associated at the age of 7 months with adverse effects on cognitive and motor skills development in infants. (inserm.fr)
  • Exposure to chlordecone seems more common in children 3 to 5 years old than in adults, with up to 18.5 % above RfD in Martinique [ 5 ]. (biomedcentral.com)
  • Accordingly, the hazards of chlordecone in people with exposure above this RfD are uncertain, and the results of exposure studies are difficult to translate into public health decisions. (biomedcentral.com)
  • Chlordecone exposure increases the risk of prostate cancer. (greenmedinfo.com)
  • In general, the results of this study, excluding chlordecone, do not show any specific levels of pesticide residues in foods or particular consumer exposure levels in the Caribbean. (anses.fr)
  • In order to assess this risk, ANSES proposed within the framework of the "Chlordecone" national action plan for 2008-2010, improved characterisation of food-based exposure of Caribbean consumers to pesticide residues. (anses.fr)
  • Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). (oregonstate.edu)
  • To validate the use of measurements of Na+/K+- ATPase in erythrocytes as a marker for the same enzyme in brain, the organochlorine pesticide chlordecone (143500), the organotins triethyltin (997502) and tributyltin (688733), mercuric-chloride (7487947) and methyl- mercury were chosen as chemical probes. (cdc.gov)
  • The pesticide chlordecone is trapped in the tortuous mesoporosity of allophane clays. (springer.com)
  • At the fourth meeting of the Conference of the Parties to the Convention from 4 to 8 May 2009, it was agreed to add chlordecone, hexabromobiphenyl, hexachlorocyclohexanes, including lindane, pentachlorobenzene, tetrabromodiphenyl ether, pentabromodiphenyl ether, hexabromodiphenyl ether and heptabromodiphenyl ether, as well as perfluorooctane sulfonic acid and its derivatives (hereinafter 'PFOS') to the Annexes to the Convention. (europa.eu)
  • In reviewing notifications of final regulatory action on carbon tetrachloride, chlordecone, endosulfan, hexazinone, pentachlorobenzene, PFOS, its salts and PFOSF, polychlorinated naphthalenes and triazophos, the Committee decided that these did not meet the criteria of Annex II to the Convention. (pic.int)
  • This limit value is based on the observation that pregnancy duration decreases with increasing plasma chlordecone concentrations. (anses.fr)
  • These results suggest that chlordecone-induced neurotoxicity may be due in part to a decrease in the inhibitory state of dopamine neurons. (fujita-hu.ac.jp)
  • Na+/K+-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: studies with chlordecone, organotins and mercury compounds. (cdc.gov)
  • MRLs: The chronic-duration oral MRL for Mirex and the intermediate-duration oral MRL for chlordecone were revised from 1995 toxicological profile only. (cdc.gov)
  • Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. (oregonstate.edu)
  • Chlordecone was used as an insecticide on tobacco, ornamental shrubs, bananas, and citrus trees, and in ant and roach traps. (cdc.gov)
  • The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. (wikipedia.org)
  • The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. (aspetjournals.org)
  • Human bile obtained from chlordecone-poisoned factory workers contained substantial amounts of free chlordecone, but little free chlordecone alcohol. (aspetjournals.org)
  • However, when the same bile specimens were pretreated with beta-glucuronidase before analysis by gas-liquid chromatography, large amounts of chlordecone alcohol appeared, accounting for 75% of total organochlorine compounds. (aspetjournals.org)
  • Confirmation of the identity of chlordecone and chlordecone alcohol was made by using gas liquid chromatography-mass spectrometry. (aspetjournals.org)
  • In contrast to human bile, rat bile contained only trace amounts of chlordecone alcohol (less than 0.5% of total chlordecone), thus indicating that hepatic metabolism of chlordecone is species-specific. (aspetjournals.org)
  • This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. (genecards.org)
  • Although high chlordecone concentrations have been reported in several crustacean species, its uptake, internal distribution, and elimination in aquatic species have never been described. (nih.gov)
  • We conclude that in man, the major metabolic route for chlordecone is its reduction in the liver followed by glucuronidation. (aspetjournals.org)
  • GC-MS monitoring resulted in the detection of chlorinated derivatives in several cultures, consistent with chlordecone biotransformation. (frontiersin.org)
  • Chlordecone is a known persistent organic pollutant (POP) that was banned globally by the Stockholm Convention on Persistent Organic Pollutants in 2009. (wikipedia.org)
  • In 2009, chlordecone was included in the Stockholm Convention on Persistent Organic Pollutants, which bans its production and use worldwide. (wikipedia.org)
  • Chlordecone is a persistent organochlorine pesticide that has been widely used in Guadeloupe (French West Indies) to control the banana weevil Cosmopolites sordidus from 1972 to 1993. (nih.gov)
  • Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio-economic concerns. (frontiersin.org)
  • Chlordecone was not federally regulated until after the Hopewell disaster, in which 29 factory workers were hospitalized with various ailments, including neurological. (wikipedia.org)
  • More interestingly, disappearance of chlordecone (50 μg/mL) in two bacterial consortia was concomitant with the accumulation of a major metabolite of formula C 9 Cl 5 H 3 (named B1) as well as two minor metabolites C 10 Cl 9 HO (named A1) and C 9 Cl 4 H 4 (named B3). (frontiersin.org)
  • ANSES has conducted several studies to assess the chlordecone risk for the French Caribbean population, in particular through the consumption of contaminated food. (anses.fr)
  • In the framework of the "Chlordecone" national action plan, ANSES conducted the Sapotille study in order to assess this risk. (anses.fr)
  • Animal studies with chlordecone have shown effects similar to those seen in people, as well as harmful kidney effects, developmental effects, and effects on the ability of females to reproduce. (cdc.gov)
  • We derive ERFs for 3 possible effects at chronic low chlordecone dose: cancers, developmental impairment, and hepatotoxicity. (biomedcentral.com)
  • This reduction takes account of new knowledge, and in particular the latest studies suggesting reprotoxic effects in rodents exposed to moderate doses of chlordecone. (anses.fr)
  • The inhabitants of the French West Indies are chronically exposed to low doses of chlordecone via local food. (biomedcentral.com)
  • What effect will occur in persons exposed above RfD: that observed at the lowest dose tested in animals, other effects known at some higher doses, or even the effect of another ubiquitous pollutant that is enhanced by chlordecone? (biomedcentral.com)
  • Chlordecone distribution in tissues of exposed prawns showed that cephalothorax organs, mainly represented by the hepatopancreas, was the most contaminated. (nih.gov)
  • However, monitoring of poisoned workers manufacturing chlordecone in the USA (Hopewell and Baltimore) revealed no renal function impairment [ 8 , 9 ]. (biomedcentral.com)
  • Workers who were exposed to high levels of chlordecone over a long period (more than one year) showed harmful effects on the nervous system, skin, liver, and male reproductive system. (cdc.gov)
  • These estimates of ingestion exposures are based on food consumption survey data matched with the results of chlordecone measurements in food made for the screening and control program. (biomedcentral.com)
  • The French islands of Martinique and Guadeloupe are heavily contaminated with chlordecone, following years of its massive and unrestricted use on banana plantations. (wikipedia.org)
  • Chlordecone was used to combat weevils in the banana plantations of Martinique and Guadeloupe from 1972 to 1993. (anses.fr)
  • Since 2003, local authorities have restricted cultivation of crops because the soil has been seriously contaminated by chlordecone. (wikipedia.org)
  • chlordecone is still present in the soil and can be found in certain plant- and animal-based foodstuffs, as well as in water at certain catchment areas used for drinking water. (anses.fr)
  • Significant decreases in whole brain and striatal DA levels were observed in chlordecone-treated mice exhibiting tremors. (fujita-hu.ac.jp)
  • Comparison of chlordecone effects on autoimmunity in (NZBxNZW)F(1) and BALB/c mice. (wordnik.com)
  • Available knowledges on mode of action and key-event hazards of chlordecone are used to identify effects of chlordecone that could occur at low dose. (biomedcentral.com)
  • Mehendale, H. M. / Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice . (fujita-hu.ac.jp)
  • and (b) central effects which come along ecuador en sildenafil del nombres comerciales with the other disavowing reality. (cadasb.org)
  • Results also showed that chlordecone was accumulated in cuticle, up to levels of 40% of the chlordecone body burden, which could be considered as a depuration mechanism since chlordecone is eliminated with the exuviae during successive moults. (nih.gov)
  • It is in no way an indicator of a person's health status and cannot therefore be used to interpret a measurement of chlordecone levels in blood or guide an individual's medical follow-up. (anses.fr)
  • Levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and the 5-HT metabolite, 5-hydroxyindole acetic acid (5-HIAA) were determined in brains of mice after daily oral administration of 10, 25 or 50 mg/kg of chlordecone or mirex until mortality occurred. (fujita-hu.ac.jp)
  • In mice treated with chlordecone or mirex, the 5-HT levels were elevated only in animals exhibiting severe tremors or diarrhea, respectively. (fujita-hu.ac.jp)
  • NE levels were not altered by chlordecone or mirex. (fujita-hu.ac.jp)
  • Both compounds are known to generate chlordecone among other degradative metabolites in environmental conditions ( Le Déault and Procaccia, 2009 ). (frontiersin.org)
  • This unidentified metabolite could be converted to free chlordecone only by acid hydrolysis under harsh conditions. (aspetjournals.org)
  • Although these observations based on small cohorts do not identify serious problems, they can nevertheless be compared with certain problems described in the past in adults exposed to chlordecone at work, characterised by short-term memory problems and the presence of intention tremor. (inserm.fr)
  • Chlordecone : health and safety guide. (who.int)
  • Long used in the French Caribbean to control the banana weevil, chlordecone can be harmful to human health. (anses.fr)
  • For many years, the Agency has been involved in assessing the health risks posed by chlordecone for the French Caribbean population. (anses.fr)
  • The Agency's activities in this area are conducted as part of the 'Chlordecone' action plans first established in 2008 by the Ministries of Health and the Overseas Territories. (anses.fr)
  • We develop methods for quantifying the health impacts of chlordecone and present the results in 2 articles: 1. (biomedcentral.com)