Chlordecone: A highly chlorinated polycyclic hydrocarbon insecticide whose large number of chlorine atoms makes it resistant to degradation. It has been shown to be toxic to mammals and causes abnormal cellular changes in laboratory animals.Mirex: An organochlorine insecticide that is carcinogenic.Bile: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.Insecticides: Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.Hydrocarbons, Chlorinated: Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Bromotrichloromethane: A potent liver poison. In rats, bromotrichloromethane produces about three times the degree of liver microsomal lipid peroxidation as does carbon tetrachloride.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Scavenger Receptors, Class B: A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.Receptors, Scavenger: A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.Antigens, CD36: Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.Receptors, Lipoprotein: Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.ATP-Binding Cassette Transporters: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.Receptors, Immunologic: Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Alkanesulfonic Acids: Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.Hexachlorobenzene: An agricultural fungicide and seed treatment agent.Endrin: An organochlorine compound that was formerly used as an insecticide. Its manufacture and use has been discontinued in the United States. (From Merck Index, 11th ed)Chlordan: A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)ChlorobenzenesHeptachlor: A man-made compound previously used to control termites and other insects. Even though production of heptachlor was phased out of use in the United States during the late 1980's it remains in soil and hazardous waste sites. It is clearly toxic to animals and humans but, the International Agency for Research on Cancer (IARC) has determined that heptachlor is not classifiable as to its carcinogenicity to humans. (From ATSDR Public Heath Statement, April 1989)Polychlorinated Biphenyls: Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61)Lindane: An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.United States Indian Health Service: A division of the UNITED STATES PUBLIC HEALTH SERVICE that is responsible for the public health and the provision of medical services to NATIVE AMERICANS in the United States, primarily those residing on reservation lands.AlaskaIndians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Inuits: Inuktitut-speakers generally associated with the northern polar region.Federal Government: The level of governmental organization and function at the national or country-wide level.Health Services, Indigenous: Health care provided to specific cultural or tribal peoples which incorporates local customs, beliefs, and taboos.United StatesSouth DakotaUnited States Public Health Service: A constituent organization of the DEPARTMENT OF HEALTH AND HUMAN SERVICES concerned with protecting and improving the health of the nation.Comprehensive Health Care: Providing for the full range of personal health services for diagnosis, treatment, follow-up and rehabilitation of patients.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Education, Veterinary: Use for general articles concerning veterinary medical education.Schools, Veterinary: Educational institutions for individuals specializing in the field of veterinary medicine.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Veterinarians: Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.Fertilizers: Substances or mixtures that are added to the soil to supply nutrients or to make available nutrients already present in the soil, in order to increase plant growth and productivity.Visual Prosthesis: Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.Legislation, Veterinary: Laws and regulations, pertaining to the field of veterinary medicine, proposed for enactment or enacted by a legislative body.Animal DiseasesPathology, Veterinary: The field of veterinary medicine concerned with the causes of and changes produced in the body by disease.

Susceptibility to chlordecone-carbon tetrachloride induced hepatotoxicity and lethality is both age and sex dependent. (1/39)

The present paper examines the susceptibility to chlordecone (Kepone, CD) and carbon tetrachloride across different ages (35, 45, and 63-days-old) in male and female Sprague-Dawley rats using different lengths of time on a CD diet (10 ppm). The principal findings are that the hepatotoxicity and mortality associated with CD-CCl4 interaction is highly age-dependent for both sexes. There was marked hepatotoxicity occurring in both sexes as they reached 45 days-of-age and females were considerably more susceptible than males to both CD-CCl4-induced hepatotoxicity and lethality. While 63-day-old females are more susceptible to the CD-CCl4 interaction than their male counterparts, the magnitude of the sex difference is diminished from that observed in 45-day-old rats. These findings challenge the hypothesis of Mehendale (1990, Med. Hypotheses 33, 289-299) that chlordecone (CD) pretreatment eliminates the well-established sex difference in CCl4-treated rats. In contrast to the CD-CCl4 findings, the sex difference in CCl4-induced hepatotoxicity was not age-dependent and was consistent over the three ages studied. The findings that CD-CCl4 interaction is highly age-dependent (within the 3 ages tested) but that CCl4-induced hepatotoxicity is not, suggest that the CD-CCl4 interaction acts via a mechanism that does not primarily involve CCl4 potentiation.  (+info)

Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. (2/39)

In order to produce a reporter gene assay for androgenic chemicals, a constitutive expression vector coding for the human androgen receptor and a reporter construct containing the firefly luciferase coding sequence under transcriptional control of the androgen responsive MMTV promoter were cotransfected into the androgen-insensitive human PC-3 prostate carcinoma cell line and stable transfectants selected. One colony of transfectants, PC-3 LUCAR+, was characterized further. 5alpha-Dihydrotestosterone (DHT) enhanced luciferase activity in a linear fashion for up to 3 days of culture. The Kd for DHT activation was within the range of 25.0-60.0 pM (r2 values >0.95). Flutamide competitively inhibited DHT activation (mean Ki value of 0.89 microM). Progesterone, estradiol, dexamethasone, and hydrocortisone were weak agonists (100-fold less effective than DHT) and diethylstilbestrol was without effect. The effects of organochlorine food contaminants (0, 0.1, 1.0, and 10.0 microM) on luciferase activity in PC-3 LUCAR+ cells were determined after exposure to the chemical for 18 h in the presence and absence of DHT (50 pM). 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) induced luciferase activity in the absence of DHT (100 microM p,p'-DDE equivalent to 50 pM DHT), but in the presence of DHT (50 pM), p,p'-DDE acted antagonistically. 2,3,7,8-Tetrachlorodibenzo-p-dioxin, kepone, butylated hydroxyanisole, and butylated hydroxytoluene all partially inhibited activation by DHT (50 pM) but alone had little or no effect. Toxaphene at 10 microM induced luciferase activity in the absence of DHT but decreased cell viability. Alpha- and delta-Hexachlorocyclohexanes (HCH) at 10 microM antagonized the DHT effect, but beta-HCH and gamma-HCH mirex, photomirex, oxychlordane, cis- and trans-nonachlor were without effect. Thus, of the chemicals tested, some interact with the human androgen receptor in vitro as agonists, others as antagonists, and some as partial agonists/antagonists.  (+info)

Salmonid sexual development is not consistently altered by embryonic exposure to endocrine-active chemicals. (3/39)

Fish sexual development is sensitive to exogenous hormone manipulation, and salmonids have been used extensively as environmental sentinels and models for biomedical research. We simulated maternal transfer of contaminants by microinjecting rainbow trout (Oncorhynchus mykiss) and chinook salmon (Oncorhynchus tshawytscha) embryos. Fish were reared for 6 months and sexed, and gonads were removed for histology and measurement of in vitro steroid production. Analysis of fat samples showed that dichlorodiphenylethylene (DDE) levels, o, p'M-DDE and p,o, p'-DDE isomers, were elevated 6 months after treatment. A preliminary study showed an increased ratio of males to females after treatment with 80 mg/kg and 160 mg/kg of the xenoestrogen o,o, p'-DDE. One fish treated with 160 mg/kg o,o, p'-DDE had gonads with cells typical of both males and females. A follow-up study, using more fish and excluding the highly toxic 160 mg/kg o,o, p'-DDE dose, showed no effect on sex ratio or gonadal histology. Embryonic exposure of monosex male trout, monosex female trout, and mixed sex salmon to o, o, p'-DDE, p,o, p'-DDE, mixtures of DDE isomers, and octylphenol failed to alter sexual development. We observed no treatment-dependent changes in in vitro gonadal steroid production in any experiments. Trout exposed in ovo and reared to maturity spawned successfully. These results suggest that mortality attributable to the xenoestrogens o,o, p'-DDE, chlordecone, and octylphenol, and the antiandrogen p,o, p'-DDE, is likely to occur before the appearance of subtle changes in sexual development. Because trout appeared to be sensitive to endocrine disruption, we cannot dismiss the threat of heavily contaminated sites or complex mixtures to normal sexual development of salmonids or other aquatic organisms.  (+info)

Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. (4/39)

Although benign, uterine leiomyomas occur with high frequency and significant morbidity in reproductive-age women, and they present a significant health problem. Leiomyomas develop in the uterine myometrium and are sensitive to ovarian hormones, making them potential target sites for endocrine disruptors. Here we utilize cell lines derived from rat uterine leiomyomas to determine if a panel of 7 organochlorine pesticides have potential agonist activity in myometrial cells using cellular and molecular in vitro assays. The organochlorine pesticides investigated have been previously characterized as having agonist activity in other hormonally responsive tissues, but their effects have not been studied in uterine myometrial cells. In Eker rat leiomyoma-derived cells, HPTE, kepone, and the alpha isomer of endosulfan stimulated proliferation, an effect dampened by the antiestrogen ICI 182,780. In addition, these compounds stimulated transcription of the vitellogenin estrogen-response element via the ER in a transcriptional reporter gene assay and induced the expression of an endogenous estrogen-responsive gene, the progesterone receptor (PR). This contrasted with the agonist profile of methoxychlor, dieldrin, toxaphene, and endosulfan-beta. These compounds, unable to stimulate proliferation of uterine leiomyoma cells, did exhibit agonistic activity in these cells at the transcriptional level in the estrogen-sensitive reporter gene assay, and they were also able to upregulate PR message. These data demonstrate that organochlorine pesticides act as estrogen receptor agonists in Eker rat uterine myometrial cells, and they indicate a need for further investigation of the potential tissue-specific agonist activity of these pesticides and their role in the pathogenesis of uterine leiomyoma.  (+info)

Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. (5/39)

Methoxychlor (MXC) is currently used to protect agricultural products from insects. Previous studies show that MXC adversely affects the ovary, but the target cells were not revealed by those studies. Therefore, the purpose of this study was to test the hypothesis that MXC induces ovarian changes by adversely affecting the antral follicles and the ovarian surface epithelium in the mouse. To test this hypothesis, cycling female CD-1 mice (39 days) were dosed with MXC (8, 16, or 32 mg/kg/day), kepone (KPN, 8 mg/kg/day, positive control), or sesame oil (vehicle control) via intraperitoneal injection for 10 or 20 days. Estrous cyclicity was evaluated daily via vaginal lavage. After dosing, ovaries were collected for histological evaluation of follicle numbers, atresia, and surface epithelial height. The results indicate that at the 20-day time point, MXC (32 mg/kg) and KPN (8 mg/kg) increased the percentage of atretic antral follicles (n= 4-9,p+info)

17beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice. (6/39)

Mirex, an organochlorine pesticide, is a potent non-phorbol ester tumor promoter in mouse skin. Previous studies have shown that female mice are 3 times more sensitive to mirex tumor promotion than male mice and that ovariectomized (OVX) female mice are resistant to mirex promotion, suggesting a role for ovarian hormones in mirex promotion. To determine whether the ovarian hormone 17-beta estradiol (E2) is responsible for the sensitivity of female mice to mirex promotion, female mice were initiated with DMBA; 2 weeks later groups of mice were OVX and implants, with or without E2, were surgically implanted subcutaneously. These mice were treated topically twice weekly with mirex for 26 weeks. E2 implanted OVX mice demonstrated high normal physiologic levels of serum E2 throughout the tumor promotion experiment. E2 implants restored by 80% the intact mirex-sensitive phenotype to the OVX mice. Consistent with a role for E2 and ERalpha and ERbeta, treatment of DMBA-initiated female mice with topical ICI 182,780, an estrogen-receptor antagonist, reduced mirex tumor multiplicity by 30%. However, in cells co-transfected with ERalpha or ERbeta and estrogen-responsive promoter reporter, mirex did not stimulate promoter reporter activity, suggesting that the promotion effect of mirex is downstream of ERalpha/beta. Finally, a tumor promotion study was conducted to determine whether E2 implants could increase the sensitivity of male mice to mirex promotion. E2 implants in male mice did increase sensitivity to mirex promotion; however, the implants did not produce the full female sensitivity to mirex tumor promotion. Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice.  (+info)

Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats. (7/39)

Our earlier histomorphometric and biochemical studies suggested that the progressive phase of the interactive toxicity of chlordecone (CD) + CCl4 involves suppression of hepatocellular regeneration. The objective of the present work was to correlate hepatocellular regeneration with CCl4 (100 microliters/kg)-induced hepatotoxicity in rats maintained for 15 days on a normal (N) diet, relative to the regenerative response in rats maintained on a diet containing either 10 ppm CD, 225 ppm phenobarbital (PB), or 10 ppm mirex (M). Hepatocellular regeneration was assessed by measuring DNA and 3H-thymidine (3H-T) incorporation, followed by autoradiographic analysis of liver sections. Hepatotoxicity was assessed by measuring plasma transaminases (aspartate and alanine) followed by histopathological observations of liver sections for necrotic, swollen, and lipid-laden cells. Lethality studies were also carried out to assess the consequence of hepatotoxicity on animal survival. Dietary 10 ppm CD potentiated the hepatotoxicity of CCl4 to a greater extent than PB or M, as evidenced by elevations in plasma enzymes. Although the serum enzymes were significantly elevated in PB rats in contrast to the slight elevations in N and M rats, they returned to normal levels by 96 hr. However, serum enzyme elevations in CD rats were progressive with time until death of the animals. Actual liver injury by CCl4 was greater in PB- than in CD-pretreated rats, as evidenced by histopathological observations. A 100% mortality occurred in CD-pretreated rats at 60 hr after CCl4 administration, whereas no mortality occurred in either N-, M-, or PB-pretreated rats, indicating recovery from liver injury. Hepatocellular nuclear DNA levels were significantly decreased starting at 6 hr after CCl4 administration to CD-pretreated rats, but not in M- or PB-pretreated rats. 3H-T incorporation into nuclear DNA as well as percentage of labeled cells showed a biphasic increase in N rats: 1 at 1-2 hr, and the other at 36-48 hr after CCl4 administration. However, only 1 peak of 3H-T incorporation at 36-48 hr was observed in the CD + CCl4 combination, which was also significantly lower when compared to that observed after the M or PB + CCl4 combination treatments. These findings suggest that there is recovery in N-, PB-, or M-pretreated rats from CCl4-induced injury by virtue of the stimulated hepatocellular regeneration and tissue repair.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice. (8/39)

Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects women more frequently than men. In the (NZB times NZW)F1 mouse, a murine SLE model, the presence or absence of estrogen markedly influences the rate of progression of disease. Three organochlorine pesticides with estrogenic effects were administered chronically to ovariectomized female (NZB times NZW)F1 mice, and we measured the time to development of renal disease, the principal clinical manifestation of lupus in this model. Treatment with chlordecone, methoxychlor, or o,p -dichlorodiphenyltrichloroethane (o,p -DDT) significantly decreased the time to onset of renal impairment, as did treatment with 17ss-estradiol used as a positive control. In an expanded study of chlordecone, we found a dose-related early appearance of elevated anti-double-strand DNA autoantibody titers that corresponded with subsequent development of glomerulonephritis. Immunohistofluorescence confirmed early deposition of immune complexes in kidneys of mice treated with chlordecone. These observations are consistent with an effect of these organochlorine pesticides to accelerate the natural course of SLE in the (NZB times NZW)F1 mouse. Although we originally hypothesized that the effect on progression of autoimmunity was due to estrogenic properties of the pesticides, autoimmune effects and estrogenicity, assessed through measurement of uterine hypertrophy, were not well correlated. This may indicate that uterine hypertrophy is a poor indicator of comparative estrogenic effects of organochlorine pesticides on the immune system, or that the pesticides are influencing autoimmunity through a mode of action unrelated to their estrogenicity.  (+info)

*Chlordecone reductase

In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction chlordecone alcohol + ... NADP+ ⇌ {\displaystyle \rightleftharpoons } chlordecone + NADPH + H+ Thus, the two substrates of this enzyme are chlordecone ... The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR. As of ... Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. ...

*Kepone

... , also known as chlordecone, is an organochlorine compound and a colourless solid. This compound is a controversial ... 2015). Determination of Median Lethal Concentration (LC50) and Behavioral Effects of Chlordecone in the Cichlid fish, Etroplus ... 2013). "pH dependence of chlordecone adsorption on activated carbons and role of adsorbent physico-chemical properties". ... link) Wong, A., and C. Ribero (2013). "Alternative agricultural cropping options for chlordecone-Polluted Martinique". Revue ...

*Mirex

Slow oxidation produces chlordecone ("Kepone"), a related insecticide that is also banned in most of the western world, but ... Mirex and chlordecone: health effects, toxicokinetics, human exposure, and environmental fate". Toxicol Ind Health. 11 (6): 1- ...

*3α-Hydroxysteroid dehydrogenase

This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This ... "Entrez Gene: AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type ... and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization ... "Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase". Biochemistry. 29 (4): 1080-7. doi: ...

*Persistent organic pollutant

Chlordecone is toxic to aquatic organisms, and classified as a possible human carcinogen. Many countries have banned ... Additions to the initial 2001 Stockholm Convention list are as following POPs: Chlordecone, a synthetic chlorinated organic ... chlordecone sale and use, or intend to phase out stockpiles and wastes. α-Hexachlorocyclohexane (α-HCH) and β- ...

*AKR1C1

... and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization ... cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone ...

*Florida panther

... chlordecone, methoxychlor, methylmercury, fenarimol, and TCDD. Of all the puma subspecies, the Florida panther has the lowest ...

*AKR1C3

... and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization ...

*Tineola bisselliella

... chlordecone and mirex at 0.06%, and dieldrin at 0.05%. Imidazole (a non-chloronated aromatic heterocyclic) at 1% also gave ...

*List of MeSH codes (D02)

... chlordecone MeSH D02.455.526.439.202 --- chlorobenzenes MeSH D02.455.526.439.202.190 --- dicofol MeSH D02.455.526.439.202.200 ...

*Endocrine disruptor

... chlordecone) and DDT and its derivatives, the herbicide atrazine, and the fungicide vinclozolin), the contraceptive 17-alpha ...

*List of EC numbers (EC 1)

... chlordecone reductase EC 1.1.1.226: 4-Hydroxycyclohexanecarboxylate dehydrogenase EC 1.1.1.227: (-)-borneol dehydrogenase EC ...
The hypothesis that liver is the site of the previously demonstrated chlordecone alcohol formation in man was tested. Human bile obtained from chlordecone-poisoned factory workers contained substantial amounts of free chlordecone, but little free chlordecone alcohol. However, when the same bile specimens were pretreated with beta-glucuronidase before analysis by gas-liquid chromatography, large amounts of chlordecone alcohol appeared, accounting for 75% of total organochlorine compounds. Confirmation of the identity of chlordecone and chlordecone alcohol was made by using gas liquid chromatography-mass spectrometry. Whereas biliary chlordecone alcohol was present predominantly as its glucuronide conjugate (93%), chlordecone was excreted primarily as the unaltered compound (72%) with only a small portion conjugated with glucuronic acid (9%). The remaining fraction of the total chlordecone measured in bile appeared to be a stable polar metabolite resistant to beta-glucuronidase. This unidentified ...
Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). In rodents, hepatic basolateral SR-BI is important in controlling plasma lipoprotein levels and cholesterol (CH) homeostasis, with major roles in reverse CH transport (RCT) and biliary excretion. The hepatic ABCG5/G8 heterodimer is a membrane transporter present on the apical surfaces of hepatocytes, and also plays a key role in biliary CH ...
Technical grade kelevan contains 94 - 98% pure kelevan, 0.1 - 2% chlordecone, and 0.5 - 4.0% inorganic salts (Maier-Bode, 1976). 2.2. Physical and Chemical Properties The technical material is a brownish substance. Some physical and chemical properties of kelevan are given in Table 1. 2.3. Analytical Methods Kelevan can be extracted from plant or animal tissues, or soils using methylene chloride, isopropanol, or acetone. It can be oxidized by refluxing with chromium trioxide in glacial acetic acid to yield chlordecone. The chlordecone is then determined by gas- liquid chromatography (GLC) techniques (Westlake et al., 1970). An analytical method using liquid chromatography/mass spectrometry has been described by Cairns et al. (1982). Table 1. Some physical and chemical properties of kelevan --------------------------------------------------------------------------- Physical state solid, powder Colour white Relative molecular mass 634.79 Melting point 91 C Vapour pressure (20 C) , 0.0014 Pa (= , ...
Any evaluation of toxicity to reproduction will have as an important consideration that events may not only be on the adults having impact on their likelihood to have children, but also impact the viability and quality of life of their potential offspring and feasibly even affect later generations. That chemicals can adversely affect reproduction in males and females is not a new concept, one only has to look at the importance of drugs as contraceptives to realize how sensitive the reproductive system can be to external chemical influences to disrupt this process. Of course in these cases, the failure of normal reproduction is a desired outcome in a contraceptive, but unfortunately we have had a number of catastrophes in which such failure has been unintentional. Many of the classic examples in chemical workers, or contamination of groundwater from chemical exposure such as dibromochloropropane (DBCP) or kepone (chlordecone) have shown the sensitivity of human reproduction to these specific ...
We utilized milk samples obtained from a survey of 219 primiparous mothers in 2009 to test for the presence of new persistent organic pollutants: hexachlorocyclohexane (HCH), pentachlorobenzene (PeCB), chlordecone, polybrominated biphenyls (PBBs), polybrominated diphenyl ethers (PBDEs), and perfluorinated compounds (PFCs), including perfluorooctane sulfonic acid (PFOS), perfluorooctane sulfonyl fluoride (PFOS-F), and perflurooctanoic acid (PFOA). 158 samples were pooled according to the mothers age, length of stay in Hong Kong, and their dietary habits (frequencies of intake of fish and other seafood, and milk and dairy products) and tested for chlordecone, PBDEs, PBBs and PFCs. All were present in our samples. Their mean and median concentrations are very high compared to findings in other countries. HCH and PeCB were tested in 73 individual samples and their mean levels were of the same order of magnitude as those reported in our previous study. The levels of PBDEs were positively associated ...
Chlorella can be taken with at least one glass of any Chlorella Powder Uk Havaiana Quanto Custa liquid per 15 tablets. 8 Bottles Spirulina 500mg x 8800 caps in total Save. Chlorella Powder Uk Havaiana Quanto Custa well spirulina is considered a superfood because of its nutrient dense content. Chlorella and spirulina combined provide an incredible variety of nutrients.. T Chloramines Chloramphenicol Chlorates chlordecone reductase Chlorella virus DNA ligase chlorethylclonidine chlorfenethol Chlorhexidine chlorhexidine gluconate Chloride Channels Friday 7 December 2007. Spirulina este foarte bogata in proteine: in 100 g de spirulina se gasesc 60-70 g de celule Exista mai multe specii de spirulina. Including whole foods like chlorella in your diet is one step you can take toward reducing your risks for cancer.. Pure Organic Chlorella (Certified Organic) tablets and powder from blue-green yaeyama pacifica chlorella 500 tablets take during is safe pregnancy algae contains essential amino acids ...
Hepatoprotective action: The natural ingredients in Liv.52 DS exhibit potent hepatoprotective properties against chemically-induced hepatotoxicity. It restores the functional efficiency of the liver by protecting the hepatic parenchyma and promoting hepatocellular regeneration. The antiperoxidative activity of Liv.52 DS prevents the loss of functional integrity of the cell membrane, maintains cytochrome P-450 (a large and diverse group of enzymes, which catalyze the oxidation of organic substances), hastens the recovery period and ensures early restoration of hepatic functions in infective hepatitis. It facilitates the rapid elimination of acetaldehyde (produced by the oxidation of ethanol that is popularly believed to cause hangovers) and ensures protection from alcohol-induced hepatic damage. Liv.52 DS also diminishes the lipotropic (compounds that help catalyze the breakdown of fat) effect in chronic alcoholism and prevents fatty infiltration of the liver. In pre-cirrhotic conditions, Liv.52 ...
Childrens body mass is so much lower than adults', toxicity testing fails to adequately take into account the negative effects of pesticides on children.
TY - JOUR. T1 - The effect of pesticides on the function of the nervous system. AU - Dési, I.. PY - 1981. Y1 - 1981. UR - http://www.scopus.com/inward/record.url?scp=0019523384&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019523384&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0019523384. VL - 12. JO - Vascular Pharmacology. JF - Vascular Pharmacology. SN - 1537-1891. IS - 2. ER - ...
methoxychlor definition: A white crystalline mixture, Cl3CCH(C6H4OCH3)2, made use of as an insecticide.; A synthetic organochlorine used as an insecticide.
Alkanes C10-C13, chloro (short-chain chlorinated paraffins) (SCCPs): 10 000 mg/kg;. Aldrin: 5 000 mg/kg;. Chlordane: 5 000 mg/kg;. Chlordecone: 5 000 mg/kg;. DDT (1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane): 5 000 mg/kg;. Dieldrin: 5 000 mg/kg;. Endosulfan: 5 000 mg/kg;. Endrin: 5 000 mg/kg;. Heptachlor: 5 000 mg/kg;. Hexabromobiphenyl: 5 000 mg/kg;. Hexachlorobenzene: 5 000 mg/kg;. Hexachlorobutadiene: 1 000 mg/kg;. Hexachlorocyclohexanes, including lindane: 5 000 mg/kg;. Mirex: 5 000 mg/kg;. Pentachlorobenzene: 5 000 mg/kg;. Perfluorooctane sulfonic acid and its derivatives (PFOS). (C8F17SO2X). (X = OH, Metal salt (O-M+), halide, amide, and other derivatives including polymers): 50 mg/kg;. Polychlorinated Biphenyls (PCB) (3): 50 mg/kg;. Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDF) (4): 5 mg/kg;. Polychlorinated naphthalenes*: 1 000 mg/kg;. Sum of the concentrations of tetrabromodiphenyl ether C12H6Br4O), pentabromodiphenyl ether (C12H5Br5O), hexabromodiphenyl ether ...
en] Sea turtles including the green turtle Chelonia mydas and the hawksbill turtle Eretmochelys imbricata are critically endangered species, facing different factors as marine pollution. There is a blatant lack of data dealing with toxicants such as metals and persistent organic pollutants (POPs) in sea turtles. We developed a strategy to apprehend levels, effects and transfer to offspring of several pollutants in sea turtles. Sampling of blood, subcutaneous tissue and eggs of 15 gravid C. mydas and E. imbricata was carried out between July and September 2008 in Martinique (Diamants beach) and Guadeloupe (Petite Terre and Marie-Galante). Blood was collected from the dorso-cervical sinus and subcutaneous tissue was sampled in shoulder of the spawning females using a 5 mm biopsy punch (Kai Europe GmbH, Germany). Total blood and serum were successfully taken for metal, POP and biomarker investigations. T-mercury was analyzed by DMA milestones while PCBs, DDT and chlordecone were analyzed by EDC ...
Devault, Damien A. and Laplanche, Christophe and Pascaline, Hélène and Bristeau, Sébastien and Mouvet, Christophe and Macarie, Hervé Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants. (2016) Environmental Science and Pollution Research, vol. 23 (n° 1). pp. 81-97. ISSN 0944-1344 Dejean, Alain and Revel, Messika and Azémar, Frédéric and Roux, Olivier Altruism during predation in an assassin bug. (2013) Naturwissenschaften, vol. 100 (n° 10). pp. 913-922. ISSN 0028-1042 Mansot, Jean-Louis and Delbé, Karl and Baranek, Philippe and Thomas, Philippe and Boucher, Florent and Vangelisti, Rene and Billaud, Denis Experimental and theoretical investigations of friction properties of graphite intercalated compounds. (2013) In: 40th Leeds-Lyon Symposium on Tribology & Tribochemistry Forum 2013, 4 September 2013 - 6 September 2013 (Lyon, France). Thomas, Philippe and Mansot, ...
Usage of Liv.52 (LiverCare ) can help regulate levels of enzymes and optimize assimilation and improve the functional efficiency of the liver. Liv.52 (LiverCare) helps restore the functional efficiency of the liver by protecting the hepatic parenchyma and assist in promoting hepatocellular regeneration. It facilitates rapid elimination of acetaldehyde, the toxic intermediate metabolite of alcohol metabolism, and helps ensure protection from alcohol-induced hepatic damage. Liv.52
Usage of Liv.52 (LiverCare ) can help regulate levels of enzymes and optimize assimilation and improve the functional efficiency of the liver. Liv.52 (LiverCare) helps restore the functional efficiency of the liver by protecting the hepatic parenchyma and assist in promoting hepatocellular regeneration. It facilitates rapid elimination of acetaldehyde, the toxic intermediate metabolite of alcohol metabolism, and helps ensure protection from alcohol-induced hepatic damage. Liv.52
Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression Roberts, Matthew A; Berger, Alvin; Bruce German, J; Mutch, David M ...
This application note from Cecil Instruments describes an effective method for organochlorine pesticide analysis in the environment by reversed phase chromatography with UV-Vis detection. The method was performed using the Adept HPLC Series System 2. The experimental conditions and subsequent results are presented.
Hepatic cirrhosis results from fibrous scarring mixed with hepatocellular regeneration in response to sustained inflammatory, toxic, metabolic, and congestive
Story at-a-glance The European Parliament recently commissioned a report outlining the benefits of organic food and farming techniques over conventionally grown food, usually grown using pesticides on crops Conventional farming operations commonly use pesticides on the foods they produce hoping for greater yields, faster, but the report revealed pesticides are toxic to humans and particularly…
This is a rarer form of acne. This type of acne stems from being exposed to motor oil or pesticides on a continual basis. If you have this type of acne then you should have the rest of your health checked as you may have been exposed to harmful pollutants. The only way to reduce this type of acne is to minimize or eliminate your exposure to motor oil and pesticides ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
HPLC Application #18282: Carbamate Pesticides on Kinetex 2.6µm C18 50 x 4.6mm ID. Column used: Kinetex® 2.6 µm C18 100 Å, LC Column 50 x 4.6 mm, Ea Part#: 00B-4462-E0
In so many ways, gardening is a very beneficial activity, not only for the environment, but for those who partake in this exercise. After properly reading the instructions, this man was in the process of applying pesticide spray to his raised-bed home garden. - Free Stock Photo Id: 16078 (2.2 MB)
One can only hope. I wonder if mrgybe will ever try to make a point without insults, belittling those who disagree with him, or outright slander? By the numbers. While mrgybe knows much about efforts for malaria control in Africa, and is willing to share it in little bits and pieces, sprinkled with insults, he doesnt know much about contaminant chemistry, or DDT toxicity, and doesnt appear to be much interested in learning. His approach throughout his responses has been to start with slander and insults, and gradually evolve his story with either more information or minor corrections when his misstatements are pointed out. He has finally evolved a position which is clear, although it still has two logic leaps in it: he is angry that the banning of DDT in this country led to a limitation in aid for malaria control with DDT. The three problems with that position are 1) he ignores or belittles the opinions of others that DDT should only be used as a last resort; 2) he ignores the availability of ...
One can only hope. I wonder if mrgybe will ever try to make a point without insults, belittling those who disagree with him, or outright slander? By the numbers. While mrgybe knows much about efforts for malaria control in Africa, and is willing to share it in little bits and pieces, sprinkled with insults, he doesnt know much about contaminant chemistry, or DDT toxicity, and doesnt appear to be much interested in learning. His approach throughout his responses has been to start with slander and insults, and gradually evolve his story with either more information or minor corrections when his misstatements are pointed out. He has finally evolved a position which is clear, although it still has two logic leaps in it: he is angry that the banning of DDT in this country led to a limitation in aid for malaria control with DDT. The three problems with that position are 1) he ignores or belittles the opinions of others that DDT should only be used as a last resort; 2) he ignores the availability of ...
Wheeler, W. B., D. P. Jouvenaz, D. P. Wojcik, W. A. Banks, C. H. Van Middelem, C. S. Lofgren, S. Nesbitt, L. Williams, and R. Brown. 1977. Mirex residues in nontarget organisms after application of 10-5 bait for fire ant control, northeast Florida--1972-74. Pestic. Monit. J. 11: 146-156. Wojcik, D. P., W. A. Banks, W. B. Wheeler, D. P. Jouvenaz, C. H. Van Middelem, and C. S. Lofgren. 1975. Mirex residues in nontarget organisms after application of experimental baits for fire ant control, Southwest Georgia--1971-72. Pestic. Monit. J. 9: 124-133, 1976. Errata 10: 31. ...
A YEAR ago, the farming industry was up in arms over proposed regulations aimed at preventing pollution. As then worded by the Scottish Government, the regulations would have prohibited any spreading of fertiliser or pesticide on slopes above 12 degrees, taking a fair percentage of land in Scotland out of production.
These natural and DIY pesticides are effective at helping to rid your crops of harmful critters, but safe enough to keep from poisoning you and your family.
Pesticides are something quite common in the nowadays agriculture, as most of the farmers use them to spray their crops, with a very powerful purpose - to prevent the damage produced by pests. Besides their advantages, pesticides also have a great disadvantage - they can harm your system to the …. Read More » ...
Article Ascentis™ RP-Amide for the Analysis of Pesticides. Application Report 209 Analysis of the Pesticides Carbaryl, Diuron, and Propachlor Using Ascentis™ RP-Amide This application demonstrates the suitability of the Ascentis RP-Amide for ...
Thus, had we merely conducted simple tests of statistical significance, we could correctly have said that the results were not statistically significant in most cases; given the number of simultaneous tests that we had conducted, the few significant exceptions could be discounted. While correct, such statements commonly lead readers of papers (and not infrequently the authors themselves) to conclude that despite an investigation aimed at uncovering evidence there is no evidence for an effect. Authors and readers may then go on to conclude that the lack of evidence indicates that there is no effect. In this respect, Pilling et al. [5] were correct to assert that given that formal analysis of their data "would lack the power to detect anything other than very large treatment effects", a formal analysis "would be potentially misleading".. However, we argue that naïve hypothesis tests are inadequate in cases such as studying the impact of thiamethoxam on honeybees, where we need to know the ...
Non-polar HP-PAS5 columns specifically designed and processed for the analysis of organochlorine pesticides. With an operating temperature range of -60...
Ive tried a lot of different things in my journey through the crazy world of health and wellness. Its hard to capture all of them in my 10 Steps, so here are 10 specific things that I believe were game-changers in my success:. 1. I learned how to relax and enjoy life in the least relaxing situation ever. Not easy, but until I figured this out, the rest was just slapping Band-Aids on a seeping wound. Life is risk, were all here to learn, and I reached out for help when I needed it. Find what works for you to neutralize emotional chaos.. 2. I juice vegetables, not fruits. I want to EAT my fruits to get all the good fiber they bring to the table. Fiber also helps slow down my bodys absorption of fructose, so I can avoid insulin spikes.. In contrast, vegetables usually pack less fructose and more anti-cancer nutrients into every square centimeter, so I juice them to make that goodness even more concentrated. (Note: I only juice organic vegetables, which have less pesticide on them. Why would I ...
The liver is the major site of clearance and degradation of foreign antigens from the portal circulation. Despite the presence of hepatic accessory cells, antibody responses to orally administered antigens are uncommon. To ascertain if hepatic accessory cells are incapable of stimulating specific subsets of T lymphocytes, freshly isolated hepatic nonparenchymal and splenic cells were cultured with a panel of antigen-specific, H-2-restricted Th1 and Th2 HTL clones. Whereas spleen cells stimulated the proliferation of both Th1 and Th2 clones, hepatic nonparenchymal cells (NPC) stimulated the proliferation of only Th1 and not Th2 clones. Adding rIL-1, rIL-6, and rIL-7, alone or in combination, to the cultures did not result in proliferation of the Th2 clones. Despite the absence of Th2 proliferation, NPC were able to stimulate the secretion of IL-3 and IL-4 by Th2 clones in the presence of antigen. Moreover, adding hepatic NPC did not inhibit spleen cells from stimulating Th2 clones in the presence ...
Breast cancer is a multifactorial disease and its etiology is linked to multiple risk factors. There are shreds of controversial evidence that exposure to organ...
Printing tips! To print chromatograms full page, change the print settings in the print dialogue window of your PDF reader software: 1) "fit" or "fit to page", 2) "landscape" for wide chromatograms or "portrait" for tall chromatograms.. ...
If you care about what is in your food, you have no greater sympathetic intellect than me.But if you are an anti-science activist, you may not understand the distinction between what is in your food and what it simply is - and there we part company.
Women who live near California farm fields sprayed with organochlorine pesticides may be more likely to give birth to children with autism, according to a study by state health officials to be
At least one in every hundred cancers diagnosed each year in Europe may be directly related to pesticide exposure. The Sick of Pesticides (...)
The Centre for Science & Environment checks pesticide levels in blood from people of four Punjab villages and finds the levels of organochlorine pesticides shocking. Harjinder Sidhu reports.
Methoxychlor was tested by the oral route only in the rat. Three experiments, including one employing dietary levels of up to 1600 ppm (equivalent to about 80 mg/kg bw/day), provided no evidence of carcinogenicity. Because of inadequate reporting, conclusions cannot be drawn from the results of a fourth experiment in which some liver tumours were observed in rats fed up to 2000 ppm in the diet (equivalent to about 100 mg/kg bw/day). Data from these four experiments do not allow an evaluation of the carcinogenicity of methoxychlor to be made at the present time.. No tumours were reported in limited skin application and subcutaneous injection (single-dose) studies. ...
Loading up on fresh produce? If youre wondering which fruits and vegetables have the most and least pesticides on them, you may want to consult this years Dirty Dozen and Clean Fifteen list.
As many of us know, we can find toxins and nasty chemicals in Virtually every thing. From the pesticides on our produce, towards the chemicals within our cosmetics, even our computers; its tough to appear by a little something fully chemical free. Every one of these chemicals and toxins are unveiled into our surroundings, traveling via our water, the air we breathe, are absorbed by human beings and wildlife with the food and h2o we consume, and thru our pores and skin. You are able tot see, touch, or odor numerous of such toxins. We typically do not come to feel their impacts right until/Unless of course we occur down by using a Persistent ailment immediately after decades of exposure. A report finished by Columbia College school of Public Wellness estimated that ninety five% of most cancers cases are a result of diet plan, and environmental toxicity ...

Demonstration of major metabolic pathways for chlordecone (kepone) in humans. | Drug Metabolism & DispositionDemonstration of major metabolic pathways for chlordecone (kepone) in humans. | Drug Metabolism & Disposition

In contrast to human bile, rat bile contained only trace amounts of chlordecone alcohol (less than 0.5% of total chlordecone), ... Whereas biliary chlordecone alcohol was present predominantly as its glucuronide conjugate (93%), chlordecone was excreted ... Confirmation of the identity of chlordecone and chlordecone alcohol was made by using gas liquid chromatography-mass ... Human bile obtained from chlordecone-poisoned factory workers contained substantial amounts of free chlordecone, but little ...
more infohttp://dmd.aspetjournals.org/content/8/6/434

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ;...Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ;...

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ... Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental ... chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was ...
more infohttps://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/f4752k638

ATSDR - ToxFAQs™: ChlordeconeATSDR - ToxFAQs™: Chlordecone

Exposure to mirex and chlordecone occurs mainly from touching or eating soil or food that contains the chemicals. At high ... What happens to mirex and chlordecone when it enters the environment?. *Mirex and chlordecone break down slowly in the ... What is mirex and chlordecone?. Mirex and chlordecone are two separate, but chemically similar, manufactured insecticides that ... This fact sheet answers the most frequently asked health questions about mirex and chlordecone. For more information, you may ...
more infohttps://www.atsdr.cdc.gov/toxfaqs/TF.asp?id=642&tid=118

Chlordecone - Substance Information - ECHAChlordecone - Substance Information - ECHA

Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...
more infohttps://echa.europa.eu/de/substance-information/-/substanceinfo/100.005.093

Frontiers | Microbial Degradation of a Recalcitrant Pesticide: Chlordecone | MicrobiologyFrontiers | Microbial Degradation of a Recalcitrant Pesticide: Chlordecone | Microbiology

Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio- ... Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio- ... More interestingly, disappearance of chlordecone (50 µg/mL) in two bacterial consortia was concomitant with the accumulation of ... More interestingly, disappearance of chlordecone (50 µg/mL) in two bacterial consortia was concomitant with the accumulation of ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2016.02025/full

Chlordecone reductase - WikipediaChlordecone reductase - Wikipedia

In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction chlordecone alcohol + ... NADP+ ⇌ {\displaystyle \rightleftharpoons } chlordecone + NADPH + H+ Thus, the two substrates of this enzyme are chlordecone ... The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR. As of ... Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. ...
more infohttps://en.wikipedia.org/wiki/Chlordecone_reductase

Chlordecone 10 µg/mL in Isooctane- CAS Number 143-50-0Chlordecone 10 µg/mL in Isooctane- CAS Number 143-50-0

Buy Chlordecone 10 µg/mL in Isooctane - CAS Number 143-50-0 from LGC Standards. Please login or register to view prices, check ... GC 1189 ; Clordecone ; 1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one, decachlorooctahydro- (6CI) ; NSC 56532 ; Chlordecone ; ...
more infohttps://www.lgcstandards.com/PL/en/Chlordecone-10-g-mL-in-Isooctane/p/DRE-L11220000IO

Bioaccumulation, distribution and elimination of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii: Field and...Bioaccumulation, distribution and elimination of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii: Field and...

Results also showed that chlordecone was accumulated in cuticle, up to levels of 40% of the chlordecone body burden, which ... In addition, depuration in chlordecone-free water was studied. Results showed that chlordecone bioconcentration in prawns was ... probably due to successive spawning leading in the elimination of chlordecone through the eggs. Chlordecone distribution in ... Chlordecone is a persistent organochlorine pesticide that has been widely used in Guadeloupe (French West Indies) to control ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/28746998

WHO HQ Library catalog › Details for: ChlordeconeWHO HQ Library catalog › Details for: Chlordecone

HQ SERIAL Chlordecone : HQ SERIAL L approche fondâee sur la notion de risque et les soins de santâe : HQ SERIAL Endosulfan / ... Chlordecone : health and safety guide. Contributor(s): World Health Organization , International Programme on Chemical Safety ... 41 , Publisher: Geneva : World Health Organization, 1990Description: 24 p ISBN: 9241510412 Subject(s): Chlordecone -- standards ...
more infohttps://kohahq.searo.who.int/cgi-bin/koha/opac-detail.pl?biblionumber=12571&shelfbrowse_itemnumber=19975

Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures |...Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures |...

Available knowledges on mode of action and key-event hazards of chlordecone are used to identify effects of chlordecone that ... We develop methods for quantifying the health impacts of chlordecone and present the results in 2 articles: 1. hazard ... We derive ERFs for 3 possible effects at chronic low chlordecone dose: cancers, developmental impairment, and hepatotoxicity. ... Inhabitants of Guadeloupe are chronically exposed to low dose of chlordecone via local food. The corresponding health impacts ...
more infohttps://ehjournal.biomedcentral.com/articles/10.1186/s12940-016-0160-x

Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice<...Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice<...

NE levels were not altered by chlordecone or mirex. These results suggest that chlordecone-induced neurotoxicity may be due in ... NE levels were not altered by chlordecone or mirex. These results suggest that chlordecone-induced neurotoxicity may be due in ... NE levels were not altered by chlordecone or mirex. These results suggest that chlordecone-induced neurotoxicity may be due in ... NE levels were not altered by chlordecone or mirex. These results suggest that chlordecone-induced neurotoxicity may be due in ...
more infohttps://pure.fujita-hu.ac.jp/en/publications/effects-of-oral-administration-of-chlordecone-and-mirex-on-brain-

CDC - NIOSH Pocket Guide to Chemical Hazards - Index of Chemical Names : CCDC - NIOSH Pocket Guide to Chemical Hazards - Index of Chemical Names : C

Chlordecone. 143-50-0. PC8575000. Chlorinated camphene *. 8001-35-2. XW5250000. Chlorinated diphenyl oxide *. ...
more infohttps://www.cdc.gov/niosh/npg/npgsyn-c.html

Guidance for Industry: Action Levels for Poisonous or Deleterious Substances in Human Food and Animal FeedGuidance for Industry: Action Levels for Poisonous or Deleterious Substances in Human Food and Animal Feed

CHLORDECONE. (The trade name for chlordecone is Kepone) Commodity. Action Level (ppm). Reference. ... Chlordecone (Kepone). Dicofol (Kelthane). DDT, DDE, TDE. Dimethylnitrosamine (Nitrosodimethylamine). Ethylene Dibromide (EDB). ...
more infohttps://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/ChemicalContaminantsMetalsNaturalToxinsPesticides/ucm077969.htm

EUR-Lex - 32014R1342 - EN - EUR-LexEUR-Lex - 32014R1342 - EN - EUR-Lex

At the fourth meeting of the Conference of the Parties to the Convention from 4 to 8 May 2009, it was agreed to add chlordecone ...
more infohttp://eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2014.363.01.0067.01.ENG

Known and Probable Human CarcinogensKnown and Probable Human Carcinogens

Kepone (chlordecone). *Lead and lead compounds. *Lindane, hexachlorocyclohexane (technical grade), and other ...
more infohttp://www.cancer.org/cancer/cancer-causes/general-info/known-and-probable-human-carcinogens.html

Case Study 53: Reproductive and Developmental Hazards | Environmental Medicine: Integrating a Missing Element into Medical...Case Study 53: Reproductive and Developmental Hazards | Environmental Medicine: Integrating a Missing Element into Medical...

Read chapter Case Study 53: Reproductive and Developmental Hazards: People are increasingly concerned about potential environmental health hazards and oft...
more infohttps://www.nap.edu/read/4795/chapter/65

WHO - Special offerWHO - Special offer

Chlordecone Year 1998 Order Number 51600043 ISBN-13 9787506610315 Price. CHF 13,00 / US$ 13,00 Developing countries CHF 9,10 ...
more infohttp://apps.who.int/bookorders/anglais/otherspublications1.jsp?lan=5

AKR1C2 aldo-keto reductase family 1 member C2 [Homo sapiens (human)] - Gene - NCBIAKR1C2 aldo-keto reductase family 1 member C2 [Homo sapiens (human)] - Gene - NCBI

pseudo-chlordecone reductase. testicular 17,20-desmolase deficiency. trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. type II ... chlordecone reductase homolog HAKRD. dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid ...
more infohttps://www.ncbi.nlm.nih.gov/gene/1646

Indian Health Manual (IHM) - HomeIndian Health Manual (IHM) - Home

CHLORDECONE (KEPONE) CLOPIDOL. CHLORINATED CAMPHENE COAL TAR PITCH VOLATILES. CHLORINATED DIPHENYL OXIDE COBALT CARBONYL. ...
more infohttps://www.ihs.gov/IHM/index.cfm?module=dsp_ihm_circ_main&circ=ihm_circ_9402_apx_942e

The EPA National Library Catalog | EPA National Library Network | US EPAThe EPA National Library Catalog | EPA National Library Network | US EPA

Chlordecone--Toxicology--United States. ; Mirex--Toxicology--United States. ; Chlordecone--Environmental aspects--United States ... Chlordecone--Toxicology--United States. ; Mirex--Toxicology--United States. ; Chlordecone--Environmental aspects--United States ... Chlordecone--Toxicology--United States ; Mirex--Toxicology--United States ; Chlordecone--Environmental aspects--United States ... Chlordecone--Environmental aspects ; Chlordecone--Toxicology ; Hexachlorocyclopentadiene--Environmental aspects ; ...
more infohttps://cfpub.epa.gov/ols/catalog/advanced_bibliography.cfm?FIELD1=SUBJECT&INPUT1=Mirex.&TYPE1=EXACT&LOGIC1=AND&COLL=&SORT_TYPE=MTIC&start_row=31

AKR1C4 Gene - GeneCards | AK1C4 Protein | AK1C4 AntibodyAKR1C4 Gene - GeneCards | AK1C4 Protein | AK1C4 Antibody

Chlordecone alcohol + NADP(+) = chlordecone + NADPH. *AK1C4_HUMAN,P17516. UniProtKB/Swiss-Prot CatalyticActivity: A 3-alpha- ... This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This ... Chlordecone Reductase; 3-Alpha Hydroxysteroid Dehydrogenase, Type I; Dihydrodiol Dehydrogenase 4 2 3 ... Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. (PMID: 2187532) Winters C.J. … ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=AKR1C4
  • Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. (oregonstate.edu)
  • Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). (oregonstate.edu)
  • Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). (oregonstate.edu)
  • Chlordecone was used as an insecticide on tobacco, ornamental shrubs, bananas, and citrus trees, and in ant and roach traps. (cdc.gov)
  • Significant decreases in whole brain and striatal DA levels were observed in chlordecone-treated mice exhibiting tremors. (fujita-hu.ac.jp)
  • The inhabitants of the French West Indies are chronically exposed to low doses of chlordecone via local food. (biomedcentral.com)
  • What effect will occur in persons exposed above RfD: that observed at the lowest dose tested in animals, other effects known at some higher doses, or even the effect of another ubiquitous pollutant that is enhanced by chlordecone? (biomedcentral.com)
  • Animal studies with chlordecone have shown effects similar to those seen in people, as well as harmful kidney effects, developmental effects, and effects on the ability of females to reproduce. (cdc.gov)
  • In addition, a recent study showed that only mouse strains predisposed to auto immune diseases developed kidney lesions after ingesting chlordecone [ 10 ]. (biomedcentral.com)
  • Bioaccumulation, distribution and elimination of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii: Field and laboratory studies. (nih.gov)
  • Although high chlordecone concentrations have been reported in several crustacean species, its uptake, internal distribution, and elimination in aquatic species have never been described. (nih.gov)
  • Chlordecone distribution in tissues of exposed prawns showed that cephalothorax organs, mainly represented by the hepatopancreas, was the most contaminated. (nih.gov)
  • The main activities of the control program are to withdraw food from the market and water from the distribution system when chlordecone is above the limit values [ 6 ]. (biomedcentral.com)
  • Results showed that chlordecone bioconcentration in prawns was dose-dependent and time-dependent. (nih.gov)
  • Results also showed that chlordecone was accumulated in cuticle, up to levels of 40% of the chlordecone body burden, which could be considered as a depuration mechanism since chlordecone is eliminated with the exuviae during successive moults. (nih.gov)
  • Finally, this study underlined the similarity of results obtained in laboratory and field approaches, which highlights their complementarities in the chlordecone behaviour understanding in M. rosenbergii. (nih.gov)
  • We develop methods for quantifying the health impacts of chlordecone and present the results in 2 articles: 1. (biomedcentral.com)
  • Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio-economic concerns. (frontiersin.org)
  • Chlordecone : health and safety guide. (who.int)
  • In addition, depuration in chlordecone-free water was studied. (nih.gov)
  • This unidentified metabolite could be converted to free chlordecone only by acid hydrolysis under harsh conditions. (aspetjournals.org)
  • Inhabitants of Guadeloupe are chronically exposed to low dose of chlordecone via local food. (biomedcentral.com)