Drug Resistance, Microbial
Microbial Sensitivity Tests
Promoter Regions, Genetic
Molecular Sequence Data
Regulatory Sequences, Nucleic Acid
Gene Expression Regulation
Drug Resistance, Multiple, Bacterial
Drug Resistance, Bacterial
Enhancer Elements, Genetic
Salmonella paratyphi A
Drug Resistance, Multiple
Protein Synthesis Inhibitors
Recombinant Fusion Proteins
Amino Acid Sequence
Repetitive Sequences, Nucleic Acid
Nucleic Acid Hybridization
DNA Transposable Elements
Sequence Homology, Nucleic Acid
Tumor Cells, Cultured
Gene Expression Regulation, Enzymologic
DNA Restriction Enzymes
Polymerase Chain Reaction
Centrifugation, Density Gradient
Gene Expression Regulation, Viral
A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA. (1/2403)The nature of the broad substrate specificity phenomenon, as manifested by multidrug resistance proteins, is not yet understood. In the Escherichia coli multidrug transporter, MdfA, the hydrophobicity profile and PhoA fusion analysis have so far identified only one membrane-embedded charged amino acid residue (E26). In order to determine whether this negatively charged residue may play a role in multidrug recognition, we evaluated the expression and function of MdfA constructs mutated at this position. Replacing E26 with the positively charged residue lysine abolished the multidrug resistance activity against positively charged drugs, but retained chloramphenicol efflux and resistance. In contrast, when the negative charge was preserved in a mutant with aspartate instead of E26, chloramphenicol recognition and transport were drastically inhibited; however, the mutant exhibited almost wild-type multidrug resistance activity against lipophilic cations. These results suggest that although the negative charge at position 26 is not essential for active transport, it dictates the multidrug resistance character of MdfA. We show that such a negative charge is also found in other drug resistance transporters, and its possible significance regarding multidrug resistance is discussed. (+info)
Synthesis of bacteriophage phi6 double-stranded ribonucleic acid. (2/2403)Uracil was incorporated into all three bacteriophage phi6 dsRNA segments throughout the infection cycle; the rates of incorporation into each of the three segments were approx. constant for the first 15 to 20 min and then increased rapidly until 50 min after infection. The medium and small dsRNA segments were produced in greater amounts than the large dsRNA segment at all times in the infection cycle. Inhibition of host RNA and protein synthesis with rifampin and chloramphenicol revealed that virus dsRNA synthesis immediately after infection was independent of either host function. (+info)
Esterases in serum-containing growth media counteract chloramphenicol acetyltransferase activity in vitro. (3/2403)The spirochete Borrelia burgdorferi was unexpectedly found to be as susceptible to diacetyl chloramphenicol, the product of the enzyme chloramphenicol acetyltransferase, as it was to chloramphenicol itself. The susceptibilities of Escherichia coli and Bacillus subtilis, as well as that of B. burgdorferi, to diacetyl chloramphenicol were then assayed in different media. All three species were susceptible to diacetyl chloramphenicol when growth media were supplemented with rabbit serum or, to a lesser extent, human serum. Susceptibility of E. coli and B. subtilis to diacetyl chloramphenicol was not observed in the absence of serum, when horse serum was used, or when the rabbit or human serum was heated first. In the presence of 10% rabbit serum, a strain of E. coli bearing the chloramphenicol acetyltransferase (cat) gene had a fourfold-lower resistance to chloramphenicol than in the absence of serum. A plate bioassay for chloramphenicol activity showed the conversion by rabbit, mouse, and human sera but not bacterial cell extracts or heated serum of diacetyl chloramphenicol to an inhibitory compound. Deacetylation of acetyl chloramphenicol by serum components was demonstrated by using fluorescent substrates and thin-layer chromatography. These studies indicate that esterases of serum can convert diacetyl chloramphenicol back to an active antibiotic, and thus, in vitro findings may not accurately reflect the level of chloramphenicol resistance by cat-bearing bacteria in vivo. (+info)
Bacteriophage SPO1 development: defects in a gene 31 mutant. (4/2403)SPO1 temperature-sensitive mutant ts14-1, located in cistron 31, has a DD (DNA synthesis-delayed) phenotype at 37 degrees C and produces progeny in a stretched program. At 44 degrees C it behaves as a DO (DNA synthesis-defective) mutant and shuts off the viral RNA synthesis about 10 min after infection. The thermal sensitivity of this mutant is due to the inactivity of gp-31 (the product of gene 31) at 44 degrees C. However, gp-31 is synthesized at that temperature and partly recovers its activity at 37 degrees C. Only 5 min at the permissive temperature is enough to trigger the continuation of the phage program and to produce progeny. The partial defect at 37 degrees C and the expansion of the middle program together with the pleiotropic defects at the nonpermissive temperature could be suitable for the study of the controls involved in bacteriophage development. (+info)
CspA, CspB, and CspG, major cold shock proteins of Escherichia coli, are induced at low temperature under conditions that completely block protein synthesis. (5/2403)CspA, CspB, and CspG, the major cold shock proteins of Escherichia coli, are dramatically induced upon temperature downshift. In this report, we examined the effects of kanamycin and chloramphenicol, inhibitors of protein synthesis, on cold shock inducibility of these proteins. Cell growth was completely blocked at 37 degrees C in the presence of kanamycin (100 microgram/ml) or chloramphenicol (200 microgram/ml). After 10 min of incubation with the antibiotics at 37 degrees C, cells were cold shocked at 15 degrees C and labeled with [35S]methionine at 30 min after the cold shock. Surprisingly, the synthesis of all these cold shock proteins was induced at a significantly high level virtually in the absence of synthesis of any other protein, indicating that the cold shock proteins are able to bypass the inhibitory effect of the antibiotics. Possible bypass mechanisms are discussed. The levels of cspA and cspB mRNAs for the first hour at 15 degrees C were hardly affected in the absence of new protein synthesis caused either by antibiotics or by amino acid starvation. (+info)
Cycloheximide and 4-OH-TEMPO suppress chloramphenicol-induced apoptosis in RL-34 cells via the suppression of the formation of megamitochondria. (6/2403)Toxic effects of chloramphenicol, an antibiotic inhibitor of mitochondrial protein synthesis, on rat liver derived RL-34 cell line were completely blocked by a combined treatment with substances endowed with direct or indirect antioxidant properties. A stable, nitroxide free radical scavenger, 4-hydroxy-2,2,6, 6-tetramethylpiperidine-1-oxyl, and a protein synthesis inhibitor, cycloheximide, suppressed in a similar manner the following manifestations of the chloramphenicol cytotoxicity: (1) Oxidative stress state as evidenced by FACS analysis of cells loaded with carboxy-dichlorodihydrofluorescein diacetate and Mito Tracker CMTH2MRos; (2) megamitochondria formation detected by staining of mitochondria with MitoTracker CMXRos under a laser confocal microscopy and electron microscopy; (3) apoptotic changes of the cell detected by the phase contrast microscopy, DNA laddering analysis and cell cycle analysis. Since increases of ROS generation in chloramphenicol-treated cells were the first sign of the chloramphenicol toxicity, we assume that oxidative stress state is a mediator of above described alternations of RL-34 cells including MG formation. Pretreatment of cells with cycloheximide or 4-hydroxy-2,2, 6,6-tetramethylpiperidine-1-oxyl, which is known to be localized into mitochondria, inhibited the megamitochondria formation and succeeding apoptotic changes of the cell. Protective effects of cycloheximide, which enhances the expression of Bcl-2 protein, may further confirm our hypothesis that the megamitochondria formation is a cellular response to an increased ROS generation and raise a possibility that antiapoptotic action of the drug is exerted via the protection of the mitochondria functions. (+info)
Antibiotic synergy and antagonism against clinical isolates of Klebsiella species. (7/2403)Minimal inhibitory concentrations of kanamycin, gentamicin, amikacin, cephalothin, and chloramphenicol were determined in Trypticase soy broth for 70 clinical isolates of Klebsiella species. Gentamicin and amikacin were the most active on a weight basis. Chloramphenicol was more active than kanamycin, and cephalothin was the least active of all. Studies using a microtiter modification of the checkerboard technique were performed to evaluate the comparative activity of the three aminoglycosides in combination with either chloramphenicol or cephalothin. The cephalothin-aminoglycoside combinations demonstrated synergy in >80% of the isolates tested. No antagonism was noted. The chloramphenicol-aminoglycoside combinations showed antagonism in 35 to 45% of the isolates tested. The data suggest that the chloramphenicol-aminoglycoside combinations be used with caution when treating serious infections where Klebsiella is a potential pathogen. (+info)
Sublethal heat stress of Vibrio parahaemolyticus. (8/2403)When Vibrio parahaemolyticsu ATCC 17802 was heated at 41 degrees C for 30 min in 100 mM phosphate-3% NaCl buffer (pH 7.0), the plate counts obtained when using Trypticase soy agar containing 0.25% added NaCl (0.25 TSAS) were nearly 99.9% higher than plate counts using Trypticase soy agar containing 5.5% added NaCl (5.5 TSAS). A similar result was obtained when cells of V. parahaemolyticus were grown in a glucose salts medium (GSM) and heated at 45 degrees C. The injured cells recovered salt tolerance within 3 h when placed in either 2.5 TSBS or GSM at 30 degrees C. The addition of chloramphenicol, actinomycin D, or nalidixic acid to 2.5 TSBS during recovery of cells grown in 2.5 TSBS indicated that recovery was dependent upon protein, ribonucleic acid (RNA, and deoxyribonucleic acid (DNA) synthesis. Penicillin did not inhibit the recovery process. Heat-injured, GSM-grown cells required RNA synthesis but not DNA synthesis during recovery in GSM. Chemical analyses showed that total cellular RNA decreased and total cellular DNA remained constant during heat injury. The addition of [6-3H]uracil, L-[U-14C]leucine, and [methyl-3H]thymidine to the recovery media confirmed the results of the antibiotic experiments. (+info)
The diagnosis of typhoid fever is based on clinical symptoms, laboratory tests such as blood cultures, and polymerase chain reaction (PCR) assays. Treatment typically involves antibiotics, which can significantly reduce the duration of illness and the risk of complications. Prevention measures include vaccination against typhoid fever, proper sanitation and hygiene practices, and avoiding consumption of contaminated food and water.
* High fever
* Abdominal pain
* Diarrhea or constipation
* Intestinal hemorrhage
* Multi-organ failure
* Salmonella Typhi bacteria
* Contaminated food or water
* Poor sanitation and hygiene practices
* International travel or contaminated food imports
* Supportive care (fluids, electrolytes, pain management)
* Vaccination against typhoid fever
* Proper sanitation and hygiene practices
* Avoiding consumption of contaminated food and water.
Symptoms of meningitis may include fever, headache, stiff neck, confusion, nausea and vomiting, and sensitivity to light. In severe cases, it can lead to seizures, brain damage, and even death.
There are several types of meningitis, including:
1. Viral meningitis: This is the most common form of the infection and is usually caused by enteroviruses or herpesviruses. It is typically less severe than bacterial meningitis and resolves on its own with supportive care.
2. Bacterial meningitis: This is a more serious form of the infection and can be caused by a variety of bacteria, such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. It requires prompt antibiotic treatment to prevent long-term complications and death.
3. Fungal meningitis: This type of meningitis is more common in people with weakened immune systems and is caused by fungi that are commonly found in the environment. It can be treated with antifungal medications.
4. Parasitic meningitis: This type of meningitis is rare and is caused by parasites that are typically found in tropical regions. It can be treated with antiparasitic medications.
Diagnosis of meningitis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, polymerase chain reaction (PCR) testing, and cerebrospinal fluid (CSF) analysis. Imaging studies, such as CT or MRI scans, may be used to rule out other conditions and to evaluate the extent of brain damage.
Treatment of meningitis depends on the cause of the infection and may include antibiotics, antiviral medications, antifungal medications, or supportive care to manage symptoms and prevent complications. Supportive care may include intravenous fluids, oxygen therapy, and pain management. In severe cases, meningitis may require hospitalization in an intensive care unit (ICU) and may result in long-term consequences such as hearing loss, learning disabilities, or cognitive impairment.
Prevention of meningitis includes vaccination against the bacteria or viruses that can cause the infection, good hygiene practices, and avoiding close contact with people who are sick. Vaccines are available for certain types of meningitis, such as the meningococcal conjugate vaccine (MenACWY) and the pneumococcal conjugate vaccine (PCV). Good hygiene practices include washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding sharing food, drinks, or personal items.
In conclusion, meningitis is a serious and potentially life-threatening infection that can affect people of all ages. Early diagnosis and treatment are crucial to prevent long-term consequences and improve outcomes. Prevention includes vaccination, good hygiene practices, and avoiding close contact with people who are sick.
Prevention of Salmonella Infections includes proper food handling and storage practices, such as cooking foods to the correct temperature, storing foods at the right refrigerator temperature, and washing hands frequently. Vaccines are also available for people who are at high risk of developing severe Salmonella infections.
Complications of a Salmonella Infection can include dehydration, bacteremia (the presence of bacteria in the bloodstream), and meningitis (inflammation of the lining around the brain and spinal cord). In rare cases, a Salmonella infection can lead to long-term health problems such as irritable bowel syndrome or reactive arthritis.
Overall, prompt treatment and proper prevention measures are important for reducing the risk of complications from a Salmonella infection.
Some common effects of chromosomal deletions include:
1. Genetic disorders: Chromosomal deletions can lead to a variety of genetic disorders, such as Down syndrome, which is caused by a deletion of a portion of chromosome 21. Other examples include Prader-Willi syndrome (deletion of chromosome 15), and Williams syndrome (deletion of chromosome 7).
2. Birth defects: Chromosomal deletions can increase the risk of birth defects, such as heart defects, cleft palate, and limb abnormalities.
3. Developmental delays: Children with chromosomal deletions may experience developmental delays, learning disabilities, and intellectual disability.
4. Increased cancer risk: Some chromosomal deletions can increase the risk of developing certain types of cancer, such as chronic myelogenous leukemia (CML) and breast cancer.
5. Reproductive problems: Chromosomal deletions can lead to reproductive problems, such as infertility or recurrent miscarriage.
Chromosomal deletions can be diagnosed through a variety of techniques, including karyotyping (examination of the chromosomes), fluorescence in situ hybridization (FISH), and microarray analysis. Treatment options for chromosomal deletions depend on the specific effects of the deletion and may include medication, surgery, or other forms of therapy.
* Redness and swelling of the conjunctiva
* Discharge (pus) in the eye
* Itching or burning sensation in the eye
* Crusting of the eyelids
* Blurred vision
* Sensitivity to light
Diagnosis is usually made based on symptoms and physical examination, but may require laboratory testing to rule out other causes.
Treatment typically includes antibiotic eye drops or ointments, which can help to clear up the infection within a few days. In severe cases, oral antibiotics may be prescribed. Anti-inflammatory medications may also be used to reduce swelling and discomfort. Good hygiene practices, such as washing hands frequently and avoiding close contact with others, can help to prevent the spread of the infection.
Prognosis is generally good, but complications can include corneal ulcers, which can lead to vision loss if left untreated. Recurrent conjunctivitis may occur in some individuals, particularly those with weakened immune systems or other underlying medical conditions.
Prevention includes good hygiene practices, avoiding close contact with others, and avoiding sharing personal items such as towels or makeup. Vaccination against streptococcal infections can also help to prevent conjunctivitis caused by this type of bacteria.
Symptoms of bacterial meningitis may include sudden onset of fever, headache, stiff neck, nausea, vomiting, and sensitivity to light. In severe cases, the infection can cause seizures, coma, and even death.
Bacterial meningitis can be diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans. Treatment typically involves antibiotics to eradicate the infection, and supportive care to manage symptoms and prevent complications.
Early diagnosis and treatment are critical to prevent long-term damage and improve outcomes for patients with bacterial meningitis. The disease is more common in certain groups, such as infants, young children, and people with weakened immune systems, and it can be more severe in these populations.
Prevention of bacterial meningitis includes vaccination against the bacteria that most commonly cause the disease, good hand hygiene, and avoiding close contact with people who are sick.
Chloramphenicol phosphotransferase-like protein family
John Fisher Stokes
Commonly prescribed drugs
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing
African tick bite fever
International Dispensary Association Foundation
Joseph Edward Smadel
Polymorphism (materials science)
Ampicillin and Chloramphenicol Resistance in Systemic Haemophilus influenzae Disease
MedlinePlus - Search Results for: CHLORAMPHENICOL
Chloramphenicol Injection: MedlinePlus Drug Information
Resistance of Salmonella serotypes to chloramphenicol*
Chloramphenicol - LiverTox - NCBI Bookshelf
Chloramphenicol ⚕️ Where To Order Next | Gradspot.com
Acute necrosis of the liver following chloramphenicol therapy - PubMed
PRIME PubMed | Synthesis of a molecularly imprinted polymer for the selective solid-phase extraction of chloramphenicol from...
Chloramphenicol | C11H12Cl2N2O5 | CID 5959 - PubChem
Subject: albendazole and chloramphenicol / Subject term: acetonitrile - PubAg Search Results
The pdx genetic marker adjacent to the chloramphenicol biosynthesis gene cluster in Streptomyces venezuelae ISP5230: functional...
Open-Label Randomized Trial of Oral Trimethoprim-Sulfamethoxazole, Doxycycline, and Chloramphenicol Compared with Trimethoprim...
chloramphenicol eye drops containing borax or boric acid buffers (boron): use in children younger than 2 years - General...
Bacteroides Infection Treatment & Management: Medical Care, Surgical Care
NHANES 2003-2004: Methicillin - Resistant Staphylococcus aureus (MRSA) Data Documentation, Codebook, and Frequencies
The spread of chloramphenicol-resistant Neisseria meningitidis in Southeast Asia - Centre for Tropical Medicine and Global...
Rocky Mountain Spotted Fever (RMSF) Medication: Antibiotics, Anticholinergic agents, Ophthamic, Topical Corticosteroids,...
BALLYA Chloramphenicol Test - BALLYA
Chloramphenicol | Davis's Drug Guide
Buy Chloramphenicol Antibiotic - Taylor Hicks
Chloramphenicol: Buy Cash | E-TALMUD
Chloramphenicol-d5 | Bacterial Inhibitor | MedChemExpress
SDA with Chloramphenicol - SMITH RIVER BIOLOGICALS
Chloramphenicol 500mg - Ritemed Available at Rose Pharmacy.
Risks of receiving chlor1
- Talk to your doctor about the risks of receiving chloramphenicol injection. (medlineplus.gov)
- She was treated with ampicillin and chloramphenicol for 72 hours and then changed to chloramphenicol alone for 9 more days after the initial Hib isolate was demonstrated to be B-lactamase positive. (cdc.gov)
- Editorial Note: Resistance of H. influenzae strains to ampicillin or chloramphenicol, conventional antimicrobial therapy for systemic (bacteremic) H. influenzae disease, is of growing concern among medical practitioners. (cdc.gov)
- Chloramphenicol injection should not be used when another antibiotic can treat your infection. (medlineplus.gov)
- Chloramphenicol is a broad spectrum antibiotic introduced into clinical practice in 1948, but which was subsequently shown to cause serious and fatal aplastic anemia and is now used rarely and reserved for severe, life-threatening infections for which other antibiotics are not available. (nih.gov)
- Solid-phase extraction (SPE) with a molecularly imprinted polymer (MIP) as sorbent has been investigated for the clean-up of the broad-spectrum bacteriostatic antibiotic chloramphenicol (CAP) in honey samples. (unboundmedicine.com)
- A JO - J Chromatogr A VL - 1132 IS - 1-2 N2 - Solid-phase extraction (SPE) with a molecularly imprinted polymer (MIP) as sorbent has been investigated for the clean-up of the broad-spectrum bacteriostatic antibiotic chloramphenicol (CAP) in honey samples. (unboundmedicine.com)
- Because the binding of chloramphenicol to 70S ribosomes is reversible, it is considered to be a bacteriostatic antibiotic, but it can also have a bactericidal effect on certain bacteria at high drug concentrations, and it can even be effective against influenza bacilli at lower concentrations. (ballyabio.com)
- 8 minutes ago, Buy Chloramphenicol Antibiotic Online from TRUST STORE! (ning.com)
- Chloramphenicol is a broad-spectrum antibiotic against bacterial infections. (medchemexpress.com)
- Chloramphenicol is a Broad-Spectrum antibiotic, considered the safest medicine for treating the most commonly occurring bacterial infections. (pipelinepharma.com)
- Chloramphenicol is an antibiotic. (pipelinepharma.com)
- First discovered in 1947 in a lab, Chloramphenicol was the first antibiotic to be made instead of extracted from a micro-organism. (pipelinepharma.com)
- Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery. (bvsalud.org)
- Chloramphenicol is an antibiotic with controversial use during pregnancy for easily crossing the placental barrier and achieving high concentrations in the fetus. (bvsalud.org)
- 25% were resistant to chloramphenicol, trimethoprim-sulfamethoxazole, or amoxicillin-clavulanic acid. (cdc.gov)
- Chloramphenicol injection is used to treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. (nih.gov)
- If you stop using chloramphenicol injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
- It may be related to chloramphenicol inhibiting the same 70S ribosome in bacteria in mitochondria of bone marrow hematopoietic cells. (ballyabio.com)
- Chloramphenicol injection may cause a decrease in the number of certain types of blood cells in the body. (medlineplus.gov)
- It is best that you receive chloramphenicol injection in the hospital so that you can be closely monitored by your doctor. (medlineplus.gov)
- Antibiotics such as chloramphenicol injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
- Chloramphenicol injection comes as a liquid to be injected into a vein by a doctor or nurse in a hospital. (medlineplus.gov)
- You should begin to feel better during the first few days of treatment with chloramphenicol injection. (medlineplus.gov)
- Use chloramphenicol injection for as long as your doctor tells you, even if you feel better. (medlineplus.gov)
- In the event of biological warfare, chloramphenicol injection may be used to treat and prevent dangerous illnesses that are deliberately spread such as plague, tularemia, and anthrax of the skin or mouth. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to chloramphenicol injection or any other medications. (medlineplus.gov)
- Other medications may also interact with chloramphenicol injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- tell your doctor if you have ever been treated with chloramphenicol injection before, especially if you experienced severe side effects. (medlineplus.gov)
- Your doctor may tell you not to use chloramphenicol injection. (medlineplus.gov)
- Note: Chloramphenicol injection (containing ethanol, glycerin or propylene glycol and other solvents), It should be extracted with a dry syringe and shaken while diluting to prevent precipitation of crystals. (ballyabio.com)
- The B fragilis group is almost uniformly susceptible to metronidazole, carbapenems, chloramphenicol, and combinations of a penicillin and beta-lactamase inhibitors. (medscape.com)
- 2023. https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/51145/all/chloramphenicol. (unboundmedicine.com)
- Chloramphenicol has also been linked to cases of acute, clinically apparent liver injury with jaundice, largely in association with aplastic anemia. (nih.gov)
- Aplastic anemia associated with parenteral chloramphenicol: review of 10 cases, including the second case of possible increased risk with cimetidine. (nih.gov)
- Fatal aplastic anemia following topical administration of ophthalmic chloramphenicol. (nih.gov)
- 1990). Three case reports have documented the occurrence of leukemia following chloramphenicol therapy in the absence of intervening aplastic anemia (IARC 1990). (nih.gov)
- 1997) found high but nonsignificant elevations of risk of aplastic anemia associated with the use of chloramphenicol in the six months before onset of aplastic anemia. (nih.gov)
- Taken together, the many case reports implicating chloramphenicol as a cause of aplastic anemia, the evidence of a link between aplastic anemia and leukemia, and the increased risk of leukemia found in some case-control studies support the conclusion that an increased cancer risk is associated with chloramphenicol exposure. (nih.gov)
- Chloramphenicol has been associated with the development of aplastic anaemia. (who.int)
- If there is an allergy to penicillin, chloramphenicol may be used. (nih.gov)
- 1989) reported that chloramphenicol use was associated with an increased risk of soft-tissue sarcoma. (nih.gov)
- The work indicates that it is possible to reduce the concentration of chloramphenicol by four times while maintaining its bacteriostatic activity, which can improve the patient 's safety profile while increasing the effectiveness of the therapy . (bvsalud.org)
- Treatment includes the following antibiotics: Doxycycline Tetracycline Chloramphenicol (less common) Tetracycline taken by mouth can permanently stain teeth that are still forming. (nih.gov)
- Chloramphenicol reversibly binds to the 50S subunit to block the action of transpeptidylase and interferes with the amino acid-tRNA terminal binding with the 50S subunit, thereby hindering the formation of new peptide chains and inhibiting protein synthesis. (ballyabio.com)
- Since chloramphenicol can also bind to the 70S of human mitochondria, it can also inhibit the protein synthesis of human mitochondria, causing toxicity to the human body. (ballyabio.com)
- You may experience this decrease in blood cells whether you are being treated with chloramphenicol for a long time or a short time. (medlineplus.gov)
- We also supply weight loss pills and several other medications buying chloramphenicol . (philschwarzmann.com)
- Chloramphenicol is extremely stable, and its aqueous solution will not fail after 5 hours of boiling. (ballyabio.com)
- Five different concentrations of chloramphenicol and two types of nanoparticles ( silica and gold ) in carbopol-based ointments were tested. (bvsalud.org)
- 1983). However, because this study was incompletely reported, the findings are considered insufficient to establish a definitive link between chloramphenicol exposure and cancer in experimental animals. (nih.gov)
- Three days later, she developed vomiting and fever up to 40.5 C (105 F). She was again started on chloramphenicol and was given three doses of ceftazidime before arrival in Houston. (cdc.gov)
- The current recommendation is a four-drug regimen (trimethoprim [TMP], sulfamethoxazole [SMX], doxycycline, and chloramphenicol) and a total treatment time of 12 to 20 weeks. (tropmedres.ac)
- Chloramphenicol is an alternative, although doxycycline is preferable because tetracyclines have been shown to be associated with a higher survival rate than chloramphenicol. (medscape.com)
- Chloramphenicol is commonly used as an ointment in the treatment of conjunctivitis and ear infections. (pipelinepharma.com)
- Resistance of Hib strains to chloramphenicol has remained at a low prevalence rate of under 1% since the first report appeared in 1972 (6). (cdc.gov)
- BALLYA Chloramphenicol Test is manufactured by BALLYA, it's rapid test for detection chloramphenicol residues in chicken meat or bee product, especially in chicken mea. (ballyabio.com)
- Chloramphenicol is the alternative choice for RMSF in pregnant women and patients allergic to tetracyclines. (medscape.com)
Mode of act1
- Wolfe, A.D. and F.E. Hahn, Mode of Action of Chloramphenicol. (medchemexpress.com)
- Residues of some veterinary drugs in animals and foods : chloramphenicol, dexamethasone, diminazene, levamisole, olaquindox, spectinomycin / monographs prepared by the Joint FAO/WHO Expert Committe on Food Additives, Rome, 1-10 February 1994. (who.int)
- 1987, 1988) reported elevated risks of childhood leukemia, which increased significantly with the number of days chloramphenicol was taken. (nih.gov)
- Chloramphenicol is used to cure different types of bacterial infection by stopping them from growing and multiplying. (pipelinepharma.com)
- 1996) found no association of chloramphenicol use with risk of adult leukemia. (nih.gov)