Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
Infections with bacteria of the genus CHLAMYDIA.
A genus of the family CHLAMYDIACEAE whose species cause a variety of diseases in vertebrates including humans, mice, and swine. Chlamydia species are gram-negative and produce glycogen. The type species is CHLAMYDIA TRACHOMATIS.
Subacute inflammation of the inguinal lymph glands caused by certain immunotypes of CHLAMYDIA TRACHOMATIS. It is a sexually transmitted disease in the U.S. but is more widespread in developing countries. It is distinguished from granuloma venereum (see GRANULOMA INGUINALE), which is caused by Calymmatobacterium granulomatis.
Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).
Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).
Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
Inflammation of the UTERINE CERVIX.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.
A genus of CHLAMYDOPHILA infecting primarily birds. It contains eight known serovars, some of which infect more than one type of host, including humans.
A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
Species of CHLAMYDIA causing pneumonitis in mice and hamsters. These isolates formerly belonged to CHLAMYDIA TRACHOMATIS.
Inflammation of the uterine salpinx, the trumpet-shaped FALLOPIAN TUBES, usually caused by ascending infections of organisms from the lower reproductive tract. Salpingitis can lead to tubal scarring, hydrosalpinx, tubal occlusion, INFERTILITY, and ectopic pregnancy (PREGNANCY, ECTOPIC)
Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.
Bacterial diseases transmitted or propagated by sexual conduct.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Pathological processes of the UTERINE CERVIX.
Proteins isolated from the outer membrane of Gram-negative bacteria.
A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
An infection of the eyes characterized by the presence in conjunctival epithelial cells of inclusion bodies indistinguishable from those of trachoma. It is acquired by infants during birth and by adults from swimming pools. The etiological agent is CHLAMYDIA TRACHOMATIS whose natural habitat appears to be the genito-urinary tract. Inclusion conjunctivitis is a less severe disease than trachoma and usually clears up spontaneously.
A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)
Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.
Pathological processes involving the URETHRA.
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Techniques used in studying bacteria.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Pathological processes of the VAGINA.
An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Infections of the genital tract in females or males. They can be caused by endogenous, iatrogenic, or sexually transmitted organisms.
A species of gram-negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal URETHRITIS. In primates it exists in parasitic association with ciliated EPITHELIAL CELLS in the genital and respiratory tracts.
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
Diseases due to or propagated by sexual contact.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER; URETHRA, and the organs of reproduction - ovaries, UTERUS; FALLOPIAN TUBES; VAGINA; and CLITORIS in women and the testes; SEMINAL VESICLES; PROSTATE; seminal ducts; and PENIS in men.
Substances elaborated by bacteria that have antigenic activity.
Infection with CHLAMYDOPHILA PSITTACI (formerly Chlamydia psittaci), transmitted to humans by inhalation of dust-borne contaminated nasal secretions or excreta of infected BIRDS. This infection results in a febrile illness characterized by PNEUMONITIS and systemic manifestations.
The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
A synthetic tetracycline derivative with similar antimicrobial activity.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Infections with bacteria of the genus CHLAMYDOPHILA.
Diseases involving the FALLOPIAN TUBES including neoplasms (FALLOPIAN TUBE NEOPLASMS); SALPINGITIS; tubo-ovarian abscess; and blockage.
Diminished or absent ability of a female to achieve conception.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
Infections with species of the genus MYCOPLASMA.
A genus of gram-negative, nonmotile bacteria which are common parasitic inhabitants of the urogenital tracts of humans, cattle, dogs, and monkeys.
A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is an oligomeric protein with a distinctive structure of fourteen subunits, arranged in two rings of seven subunits each. The protein was originally studied in BACTERIA where it is commonly referred to as GroEL protein.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Infections with bacteria of the family CHLAMYDIACEAE.
Proteins found in any species of bacterium.
A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
A family of gram-negative, coccoid microorganisms, in the order CHLAMYDIALES, pathogenic for vertebrates. Genera include CHLAMYDIA and CHLAMYDOPHILA.
Infections in birds and mammals produced by various species of Trichomonas.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Purulent infections of the conjunctiva by several species of gram-negative, gram-positive, or acid-fast organisms. Some of the more commonly found genera causing conjunctival infections are Haemophilus, Streptococcus, Neisseria, and Chlamydia.
Substances that reduce the growth or reproduction of BACTERIA.
Sexual activities of humans.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Used as a support for ion-exchange chromatography.
A common inhabitant of the vagina and cervix and a potential human pathogen, causing infections of the male and female reproductive tracts. It has also been associated with respiratory disease and pharyngitis. (From Dorland, 28th ed)
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Infections with bacteria of the order MYCOPLASMATALES.
Identification of those persons (or animals) who have had such an association with an infected person, animal, or contaminated environment as to have had the opportunity to acquire the infection. Contact tracing is a generally accepted method for the control of sexually transmitted diseases.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
The external and internal organs related to reproduction.
A clear or white discharge from the VAGINA, consisting mainly of MUCUS.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
The practice of indulging in sexual relations for money.
Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).
Pathological processes involving the PHARYNX.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby's eyes are contaminated during passage through the birth canal.
A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract.
Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
A republic in western Africa, constituting an enclave within SENEGAL extending on both sides of the Gambia River. Its capital is Banjul, formerly Bathurst.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.
A species of gram-negative bacteria found in the human genitourinary tract (UROGENITAL SYSTEM), oropharynx, and anal canal. Serovars 1, 3, 6, and 14 have been reclassed into a separate species UREAPLASMA parvum.
Married or single individuals who share sexual relations.
Pneumonia caused by infections with the genus CHLAMYDIA; and CHLAMYDOPHILA, usually with CHLAMYDOPHILA PNEUMONIAE.
The functional hereditary units of BACTERIA.
Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Infections with bacteria of the genus UREAPLASMA.
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
A genus of the family CHLAMYDIACEAE comprising gram-negative non CHLAMYDIA TRACHOMATIS-like species infecting vertebrates. Chlamydophila do not produce detectable quantities of glycogen. The type species is CHLAMYDOPHILA PSITTACI.
A branch of medicine which deals with sexually transmitted disease.
Individuals requesting induced abortions.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Those facilities which administer health services to individuals who do not require hospitalization or institutionalization.
A slightly alkaline secretion of the endocervical glands. The consistency and amount are dependent on the physiological hormone changes in the menstrual cycle. It contains the glycoprotein mucin, amino acids, sugar, enzymes, and electrolytes, with a water content up to 90%. The mucus is a useful protection against the ascent of bacteria and sperm into the uterus. (From Dictionary of Obstetrics and Gynecology, 1988)
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. (1/2917)

Both chlamydial and human heat shock protein 60s (HSP 60), which colocalize in human atheroma, may contribute to inflammation during atherogenesis. We tested the hypothesis that chlamydial or human HSP 60 activates human endothelial cells (ECs), smooth muscle cells (SMCs), and monocyte-derived macrophages. We examined the expression of adhesion molecules such as endothelial-leukocyte adhesion molecule-1 (E-selectin), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), and the production of the proinflammatory cytokine interleukin-6 (IL-6). We also tested whether either HSP 60 induces nuclear factor-kappaB (NF-kappaB), which contributes to the gene expression of these molecules. Either chlamydial or human HSP 60 induced E-selectin, ICAM-1, and VCAM-1 expression on ECs similar to levels induced by Escherichia coli lipopolysaccharide (LPS). Each HSP 60 also significantly induced IL-6 production by ECs, SMCs, and macrophages to an extent similar to that induced by E. coli LPS, as assessed by enzyme-linked immunosorbent assay (ELISA). In ECs, either HSP 60 triggered activation of NF-kappaB complexes containing p65 and p50 Rel proteins. Heat treatment abolished all these effects, but did not alter the ability of E. coli LPS to induce these functions. Chlamydial and human HSP 60s therefore activate human vascular cell functions relevant to atherogenesis and lesional complications. These findings help to elucidate the mechanisms by which a chronic asymptomatic chlamydial infection might contribute to the pathophysiology of atheroma.  (+info)

Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis. (2/2917)

The molecular mechanisms of resistance to genital infection with the mouse pneumonitis (MoPn) strain of Chlamydia trachomatis are unknown. A role for major histocompatibility complex class II-restricted, interleukin-12-dependent CD4(+) T cells has been established, but the functional activity of these cells does not depend on secretion of gamma interferon. Here we examined the potential contribution of T-cell-mediated cytotoxicity and apoptosis to mucosal clearance of MoPn by using mice deficient in the molecular mediators of target cell lysis. Animals lacking perforin, Fas, Fas ligand, or both perforin and Fas ligand were infected genitally with C. trachomatis MoPn and monitored for expression of immunity to chlamydial antigens and clearance of MoPn from the genital mucosa. In each case, the profile of spleen cytokine production, the magnitude of the host antibody response, and the kinetics of chlamydial clearance were similar to those of genetically intact controls. Compensatory overproduction of tumor necrosis factor alpha, an alternate mediator of apoptosis in certain cell types, did not appear to account for the ability of mutant mice to resolve Chlamydia infections. These results fail to support CD4(+) T-cell-mediated apoptosis or CD8(+) T-cell-mediated cytotoxicity as being critical to the clearance of C. trachomatis MoPn urogenital infections.  (+info)

Nongonococcal urethritis--a new paradigm. (3/2917)

Urethritis in men has been categorized historically as gonococcal or nongonococcal (NGU). The major pathogens causing NGU are Chlamydia trachomatis and Ureaplasma urealyticum. Trichomonas vaginalis may be involved occasionally. In up to one-half of cases, an etiologic organism may not be identified. In this review we present recent advances in the diagnosis and management of NGU and discuss how they may be applied in a variety of clinical settings, including specialized STD clinics and primary health care practices. In particular, the development of the noninvasive urine-based nucleic acid amplification tests may warrant rethinking of the traditional classification of urethritis as gonococcal urethritis or NGU. Diagnostic for Chlamydia are strongly recommended because etiologic diagnosis of chlamydial urethritis may have important public health implications, such as the need for partner referral and reporting. A single 1-g dose of azithromycin was found to be therapeutically equivalent to the tetracyclines and may offer the advantage of better compliance.  (+info)

Chlamydia infections and heart disease linked through antigenic mimicry. (4/2917)

Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein.  (+info)

Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis. (5/2917)

An in vitro coculture model system was used to explore conditions that trigger neutrophil chemotaxis to Chlamydia trachomatis infected human epithelial cells (HEC-1B). Polarized HEC-1B monolayers growing on extracellular matrix (ECM) were infected with C. trachomatis serovar E. By 36 h, coincident with the secretion of chlamydial lipopolysaccharide and major outer membrane protein to the surfaces of infected cells, human polymorphonuclear neutrophils (PMNL) loaded with azithromycin migrated through the ECM and infiltrated the HEC-1B monolayer. Bioreactive azithromycin was delivered by the chemotactic PMNL to infected epithelial cells in concentrations sufficient to kill intracellular chlamydiae. However, residual chlamydial envelopes persisted for 4 weeks, and PMNL chemotaxis was triggered to epithelial cells containing residual envelopes. Infected endometrial cells demonstrated up-regulation of ENA-78 and GCP-2 chemokine mRNA. Thus, despite appropriate antimicrobial therapy, residual chlamydial envelope antigens may persist in infected tissues of culture-negative women and provide one source for sustained inflammation.  (+info)

Mailed, home-obtained urine specimens: a reliable screening approach for detecting asymptomatic Chlamydia trachomatis infections. (6/2917)

The use of mailed, home-obtained urine specimens could facilitate screening programs for the detection of asymptomatic Chlamydia trachomatis infections. Since transport time could have an adverse effect on the sensitivity of C. trachomatis detection by PCR, the influence of DNA degradation on amplification was monitored over the course of 1 week. Therefore, urine specimens were aliquoted on the day of collection or arrival. Two groups of urine specimens were investigated. Group I contains first-void C. trachomatis-positive and -negative urine samples. DNA degradation was monitored in group I samples for 7 days at room temperature (RT) and at 4 degrees C by amplifying different lengths of the human beta-globin gene and the C. trachomatis plasmid target. DNA degradation was observed only for the larger human beta-globin fragments at days 5 to 7 at RT. In contrast, at 4 degrees C all targets could be amplified. Urine specimens were also frozen and thawed before aliquoting to mimic freezing during transport. This resulted in a lower sensitivity for the detection of C. trachomatis after thawing and 3 to 4 days at RT. In addition, mailed, home-obtained C. trachomatis-positive urine specimens (group II) were analyzed for 7 days after arrival by two commercially available C. trachomatis detection systems (PCR and ligase chain reaction [LCR]). The C. trachomatis plasmid target in mailed, home-obtained urine specimens could be amplified by both PCR and LCR after 1 week of storage and/or transport at RT. In conclusion, our findings indicate that mailed, home-obtained urine specimens are suitable for the sensitive detection of asymptomatic C. trachomatis infections by amplification methods, even if the transport time is up to 1 week at RT. These findings support the feasibility and validity of screening programs based on mailed, home-obtained urine specimens. Larger studies should be initiated to confirm our results.  (+info)

Chlamydia trachomatis infections: progress and problems. (7/2917)

Chalmydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to initiate community-based screening programs aimed at identifying asymptomatically infected men and women. Directly observed single-dose therapy with azithromycin is now available. Screening programs have been demonstrated to reduce the overall prevalence of chlamydial infection in the tested population and to reduce the incidence of subsequent pelvic inflammatory disease in previously screened women. The sequelae of chlamydial infections are likely due to immunopathologically mediated events in which both the chlamydial 60 kDa heat-shock protein and genetic predisposition of specific patients play a role. An improved understanding of immunologic events leading to upper genital tract scarring is needed to target specific interventions and facilitate development of a vaccine.  (+info)

Immunity to Chlamydia trachomatis mouse pneumonitis induced by vaccination with live organisms correlates with early granulocyte-macrophage colony-stimulating factor and interleukin-12 production and with dendritic cell-like maturation. (8/2917)

As is true for other intracellular pathogens, immunization with live Chlamydia trachomatis generally induces stronger protective immunity than does immunization with inactivated organism. To investigate the basis for such a difference, we studied immune responses in BALB/c mice immunized with viable or UV-killed C. trachomatis mouse pneumonitis (MoPn). Strong, acquired resistance to C. trachomatis infection was elicited by immunization with viable but not dead organisms. Immunization with viable organisms induced high levels of antigen-specific delayed-type hypersensitivity (DTH), gamma interferon production, and immunoglobulin A (IgA) responses. Immunization with inactivated MoPn mainly induced interleukin-10 (IL-10) production and IgG1 antibody without IgA or DTH responses. Analysis of local early cytokine and cellular events at days 3, 5, and 7 after peritoneal cavity immunization showed that high levels of granulocyte-macrophage colony-stimulating factor and IL-12 were detected with viable but not inactivated organisms. Furthermore, enrichment of a dendritic cell (DC)-like population was detected in the peritoneal cavity only among mice immunized with viable organisms. The results suggest that early differences in inducing proinflammatory cytokines and activation and differentiation of DCs may be the key mechanism underlying the difference between viable and inactivated organisms in inducing active immunity to C. trachomatis infection.  (+info)

TY - JOUR. T1 - Immunobiology of monocytes and macrophages during Chlamydia trachomatis infection. AU - Nielsen, Mads Lausen. AU - Christiansen, Gunna. AU - Poulsen, Thomas Bouet Guldbæk. AU - Birkelund, Svend. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Infections caused by the intracellular bacterium Chlamydia trachomatis are a global health burden affecting more than 100 million people annually causing damaging long-lasting infections. In this review, we will present and discuss important aspects of the interaction between C. trachomatis and monocytes/macrophages.. AB - Infections caused by the intracellular bacterium Chlamydia trachomatis are a global health burden affecting more than 100 million people annually causing damaging long-lasting infections. In this review, we will present and discuss important aspects of the interaction between C. trachomatis and monocytes/macrophages.. KW - Chlamydia trachomatis. KW - Macrophages. KW - Monocytes. UR - ...
Chlamydia trachomatis serovar E is one of the most common bacterial sexually transmitted pathogens. Since it is an obligate intracellular bacterium, efficient colonization of genital mucosal epithelial cells is crucial to the infectious process. Serovar E elementary bodies (EB) metabolically radiolabeled with 35S-Cys-Met and harvested from microcarrier bead cultures, which significantly improves the infectious EB-to-particle ratio, provided a more accurate picture of the parameters of attachment of EB to human endometrial epithelial cells (HEC-1B) than did less infectious 14C-EB harvested from flask cultures. Binding of serovar E EB was (i) equivalent at 35 and 4 degrees C, (ii) decreased by preexposure of EB to heat or the topical microbicide C31G, (iii) comparable among common eukaryotic cell lines (HeLa, McCoy), and (iv) significantly increased to the apical surfaces of polarized cells versus nonpolarized cells. In parallel experiments with C. trachomatis serovar L2, serovar E attachment was ...
In an attempt to establish a model of chlamydial ascending salpingitis and infertility, three inbred strains of mice, C3H/HeN (H-2k), C57BL/6N (H-2b), and BALB/cAnN (H-2d), were inoculated intravaginally with 3 x 10(7) inclusion-forming units of the Chlamydia trachomatis mouse pneumonitis biovar. Mice mated 6 weeks following inoculation were found to have a significant decrease in fertility rate compared with the control groups, as shown by a reduction in the number of pregnant mice and a decrease in the number of embryos. ...
In this work, the geometrical characteristics of two different types of cells observed with Electron Microscopy were analysed. The nuclear envelope of Wild-type HeLa cells and Chlamydia trachomatis-infected HeLa cells were automatically segmented and then modelled against a spheroid and converted to a two-dimensional surface. Geometric measurements from this surface and the volumetric nuclear envelope were extracted to compare the two types of cells. The measurements included the nuclear volume, the sphericity of the nucleus, its flatness or spikiness. In total 13 different cells were segmented: 7 Wild-type and 6 Chlamydia trachomatis-infected. The cells were statistically different in the following measurements. Wild-type HeLa cells have greater volumes than that of Chlamydia trachomatis-infected HeLa cells and they are more spherical as Jaccard index suggests. Standard deviation (σ), and range of values for the nuclear envelope, which shows the distance of the highest peaks and deepest ...
The obligate intracellular bacterium Chlamydia trachomatis is a major human pathogen and a main cause of genital and ocular diseases. During its intracellular cycle, C. trachomatis replicates inside a membrane-bound vacuole termed an inclusion. Acquisition of lipids (and other nutrients) from the host cell is a critical step in chlamydial replication. Lipid droplets (LD) are ubiquitous, ER-derived neutral lipid-rich storage organelles surrounded by a phospholipids monolayer and associated proteins. Previous studies have shown that LDs accumulate at the periphery of, and eventually translocate into, the chlamydial inclusion. These observations point out to Chlamydia-mediated manipulation of LDs in infected cells, which may impact the function and thereby the protein composition of these organelles. By means of a label-free quantitative mass spectrometry approach we found that the LD proteome is modified in the context of C. trachomatis infection. We determined that LDs isolated from C. ...
Objectives: Sampling of both the cervix and urine increases the chance of detection of Chlamydia trachomatis compared with sampling either site alone. We determined the effect of combining urine and cervical swab specimens in the clinic setting on the sensitivity of C trachomatis polymerase chain reaction (PCR) testing.. Methods: For each of 100 women attending a genitourinary medicine clinic with high likelihood of genital C trachomatis infection, one endocervical swab was placed in transport medium and another in one of two aliquots of first void urine. Four PCR assays per patient (urine + swab, swab alone, and urine alone both pre- and post-freeze-thawing) were processed by automated C trachomatis PCR (Cobas, Amplicor). An inhibition control was included with each assay to identify specimens containing PCR inhibitors.. Results: 71% of women were Amplicor C trachomatis PCR positive (according to the results of at least one specimen). PCR test results were concordant for 95/100 patients, and of ...
The present disclosure relates to a solid phase immunoassay for the detection of Chlamydia trachomatis antigens in a clinical specimen, wherein the Chlamydia trachomatis antigens to be determined are coated or adsorbed on the solid phase.
TY - JOUR. T1 - HPV and Chlamydia trachomatis co-detection in young asymptomatic women from high incidence area for cervical cancer. AU - Bellaminutti, Serena. AU - Seraceni, Silva. AU - de Seta, Francesco. AU - Gheit, Tarik. AU - Tommasino, Massimo. AU - Comar, Manola. PY - 2014. Y1 - 2014. N2 - Chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (HPV) cofactor in cervical cancer. The aim of this study is to evaluate the prevalence of Chlamydia trachomatis and HPV co-infection in different cohorts of asymptomatic women from a Northern Italy area at high incidence for cervical cancer. Cervical samples from 441 females were collected from Cervical Cancer Screening Program, Sexually Transmitted Infectious and Assisted Reproductive Technology centres. HPV and Chlamydia trachomatis were detected simultaneously and genotyped using a highly sensitive bead based assay. The overall prevalence of Chlamydia trachomatis was estimated 9.7%, in ...
Chlamydia trachomatis Serovar D ATCC ® VR-885™ Designation: Trachoma type D strain UW-3/Cx Application: Sexually Transmitted Disease Research
article{2075419, abstract = {BACKGROUND: In many developing countries, little is known about the prevalence of genital Chlamydia trachomatis infections and complications, such as infertility, thus preventing any policy from being formulated regarding screening for C. trachomatis of patients at risk for infertility. The objective of the present study was to determine the prevalence of C. trachomatis and evaluate the diagnostic utility of serological markers namely anti-C. trachomatis IgG and IgA antibodies in women attending an infertility clinic. METHODS: Serum and vaginal swab specimens of 303 women presenting with infertility to the infertility clinic of the Kigali University Teaching Hospital and 312 fertile controls who recently delivered were investigated. Two commercial species-specific ELISA were used to determine serum IgG and IgA antibodies to C. trachomatis and vaginal swabs specimens were tested by PCR. Hysterosalpingography (HSG) was performed in subfertile women. RESULTS: The PCR ...
The gene encoding the major outer membrane protein of the Chlamydia trachomatis mouse pneumonitis biovar was sequenced and the amino acid sequence deduced. The primary structure of this protein is similar to that of the lymphogranuloma venereum and trachoma biovars in that it consists of four variab …
Copyright © 2017 American Society for Microbiology. All Rights Reserved. Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and can cause significant reproductive morbidity in women. There is insufficient knowledge of C. trachomatis-specific immune responses in humans, which could be important in guiding vaccine development efforts. In contrast, murine models have clearly demonstrated the essential role of T helper type 1 (Th1) cells, especially interferon gamma (IFN-γ)-producing CD4+ T cells, in protective immunity to chlamydia. To determine the frequency and magnitude of Th1 cytokine responses elicited to C. trachomatis infection in humans, we stimulated peripheral blood mononuclear cells from 90 chlamydia-infected women with C. trachomatis elementary bodies, Pgp3, and major outer membrane protein and measured IFN-γ-, tumor necrosis factor alpha (TNF-α)-, and interleukin-2 (IL-2)-producing CD4+ and CD8+ T-cell responses using intracellular ...
AIMS--To examine the role of Chlamydia trachomatis in ectopic pregnancy by detection of DNA in archival salpingectomy specimens, and in their preceding cervical specimens and endometrial biopsies, by using the polymerase chain reaction (PCR). METHODS--Archival paraffin embedded salpingectomy tissues (n = 48) from 37 women with ectopic pregnancy were examined for the presence of C trachomatis plasmid and omp1 DNA by PCR. In addition, preceding cervical specimens (n = 58) stored either as cervical cell suspensions or as archival cervical smears, and preceding endometrial biopsies (n = 18), taken 0-5.8 years before the ectopic pregnancy, were examined by PCR for the presence of C trachomatis. RESULTS--C trachomatis DNA was detected in only one of the 48 salpingectomy specimens from 37 women. However, in six of the 37 women, C trachomatis DNA was detected in the genital specimens (cervix and/or endometrial) taken before salpingectomy. C trachomatis infections were mostly found in endometrial or ...
A method is described in which smears on slides, which had been examined previously in a direct fluorescence antibody (DFA) test for Chlamydia trachomatis, were tested by the polymerase chain reaction (PCR). Twenty four (73%) of 33 smears which contained fewer than 10 elementary bodies when examined by the DFA test were positive by the PCR. Of the nine negative smears, seven contained only one or two elementary bodies. However, single elementary bodies were detected by the PCR in seven of the 24 positive samples. Fifteen smears were negative by both methods. The ability to detect small numbers of elementary bodies by the PCR and its specificity for negative smears indicates its potential for retrospective analysis of stored, archival smears on slides.. ...
Detection of Chlamydia trachomatis antigens in first-void urine to identify asymptomatic male carriers.: Early morning first-void urine collected from 279 sexua
With more than 90 million new cases annually, Chlamydia trachomatis is the most common sexually transmitted bacterial disease. Untreated endocervical C. trachomatis infections can cause pelvic inflammatory disease (PID), a disorder of the endometrium, fallopian tubes, and adjacent structures that occurs after ascension of the bacterium from the lower to upper genital tract. Adverse outcomes secondary to C. trachomatis-induced PID include tubal infertility, ectopic pregnancy, and chronic pelvic pain. Vaccine development has been identified as essential for control of C. trachomatis infections, and current evidence suggests that an effective vaccine will likely be based on several C. trachomatis antigens. Experimental models of infection have identified HSP60, major outer-membrane protein (MOMP), outer membrane protein 2 (OMP2), and polymorphic membrane protein D (PmpD) as promising vaccine candidates. A prospective study of Kenyan commercial sex workers found that production of interferon-gamma ...
NATtrol Chlamydia Trachomatis serotype D External Run Control is ready to use, inactivated full process controls designed to evaluate performance of molecular tests. They can be used for verification of assays, training of laboratory personnel and to monitor assay-kit lot performance.
Chlamydia trachomatis causes a high number of sexually transmitted infections worldwide, but reproducible and precise strain typing to link partners is lacking. We evaluated multilocus sequence typing (MLST) for this purpose by detecting sequence types (STs) concordant for the ompA genotype, a single-locus typing standard. We tested samples collected during April 2000-October 2003 from members of established heterosexual partnerships (dyads) in the Indianapolis, Indiana, USA, area who self-reported being coital partners within the previous 30 days. C. trachomatis DNA from 28 dyads was tested by MLST; sequences were aligned and analyzed for ST and phylogenetic relationships. MLST detected 9 C. trachomatis STs, 4 unique to Indianapolis; STs were identical within each dyad. Thirteen unique strains were identified; 9 (32%) dyads harbored novel recombinant strains that phylogenetically clustered with strains comprising the recombinants. The high rate of novel C. trachomatis recombinants identified supports
The Gram-negative, intracellular bacterium Chlamydia trachomatis causes acute and chronic urogenital tract infection, potentially leading to infertility and ectopic pregnancy. The only partially characterized cytotoxin CT166 of serovar D exhibits a DXD motif, which is important for the enzymatic activity of many bacterial and mammalian type A glycosyltransferases, leading to the hypothesis that CT166 possess glycosyltransferase activity. CT166-expressing HeLa cells exhibit actin reorganization, including cell rounding, which has been attributed to the inhibition of the Rho-GTPases Rac/Cdc42. Exploiting the glycosylation-sensitive Ras(27H5) antibody, we here show that CT166 induces an epitope change in Ras, resulting in inhibited ERK and PI3K signaling and delayed cell cycle progression. Consistent with the hypothesis that these effects strictly depend on the DXD motif, CT166 with the mutated DXD motif causes neither Ras-ERK inhibition nor delayed cell cycle progression. In contrast, CT166 with the
Our research addresses the molecular basis of the interactions between disease-causing bacteria and their mammalian hosts. In particular, we study the intracellular biology of the obligate intracellular bacterium Chlamydia trachomatis. C.trachomatis is the leading bacterial agent of sexually transmitted disease worldwide and in developing nations causes blindness (trachoma), a neglected tropical disease.. Chlamydia forces its own entry into eukaryotic cells and forges a replicative niche within a specialised membrane-bound compartment (an inclusion), reprogrammed by the bacteria to mimic a host organelle. The inclusion remains segregated from the cellular endocytic pathway but is able to selectively engage with the secretory pathway.. Like some other Gram-negative bacteria including Salmonella and enteropathogenic E.coli, Chlamydia encodes a type III secretion system (T3SS), a sophisticated macromolecular assembly that spans the bacterial envelope and translocates virulence effector proteins ...
Mouse monoclonal antibody raised against Chlamydia trachomatis LPS. Chlamydia trachomatis elementary bodies, L2 serovar. (MAB6165) - Products - Abnova
TY - JOUR. T1 - Asymptomatic urethral infections due to chlamydia trachomatis in male u.s. military personnel. AU - Podoore, John K.. AU - Holmes, Kino K.. AU - Alexander, E. R.. PY - 1982/12. Y1 - 1982/12. N2 - Asymptomatic genital infections due to C. trachomatis represent the major form of chlamydial genital infection in women. The prevalence of asymptomatic urethral infection due to C. trachomatis in men is not as welldocumented. Previous surveys of chlamydial infection in asymptomatic men have been conducted in selected populations of men attending sexually transmitted disease clinics for various nongenitourinary complaints; prevalence rates were 0-7010 [2]. In the present study we evaluated the prevalence of urethral infection due to C. trachomatis in sexuallyactive enlisted men in the U.S. Army when presenting to the troop medical clinic for routine examination.. AB - Asymptomatic genital infections due to C. trachomatis represent the major form of chlamydial genital infection in women. ...
The obligate intracellular bacterium Chlamydia trachomatis is the most common sexually-transmitted pathogen in the developed world, |100 million persons are inf...
Microimmunofluorescence (MIF), a Chlamydia trachomatis species-specific enzyme immunoassay incorporating lipopolysaccharide-extracted Chlamydia trachomatis L2 elementary bodies, two different synthetic peptide-based species-specific tests, and a recombinant lipopolysaccharide genus-specific test wer …
Objective: To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. To investigate factors associated with these measures. Design: Cross sectional survey of people randomly selected from general practice registers. Invitation to provide a specimen collected at home. Setting: England. Participants: 19 773 men and women aged 16-39 years invited to participate in screening. Main outcome measures: Coverage and uptake of screening; prevalence of chlamydia. Results: Coverage of chlamydia screening was 73% and was lower in areas with a higher proportion of non-white residents. Uptake in 16-24 year olds was 31.5% and was lower in men, younger adults, and practices in disadvantaged areas. Overall prevalence of chlamydia was 2.8% (95% confidence interval 2.2% to 3.4%) in men and 3.6% (3.1% to 4.9%) in women, but it was higher in people younger than 25 years (men 5.1%; 4.0% to 6.3%; women 6.2
Chlamydia trachomatis Serovar Ba ATCC ® VR-347™ Designation: Apache-2 Application: Sexually Transmitted Disease Research
Greenwell, Pamela, Kakourou , Georgia and Rughooputh, Sanjiv (2006) Analysis of glycosidases activity in Chlamydia trachomatis L2 serotype. Internet Journal of Medical Update, 1 (1). ISSN 1694-0423 Full text not available from this repository ...
Chlamydia trachomatis serovars D-K are the leading cause of bacterially-acquired sexually transmitted infections in the United States. As an obligate intracellular pathogen, C. trachomatis infects columnar epithelial cells of the genital mucosae and can cause deleterious sequelae such as pelvic inflammatory disease, infertility, and ectopic pregnancy. Several chlamydial antigens reach the host cell cytosol prior to the natural release of chlamydiae at the end of the developmental cycle. While some of these extra-inclusion antigens traffic to the host cell surface, others remain intracellular where they are proposed to influence vital host cell functions and antigen trafficking and presentation. The research herein examines the escape and trafficking of the immunodominant chlamydial antigens MOMP, LPS, and cHsp60 within C. trachomatis serovar E-infected polarized human endometrial epithelial cells. Studies using high-resolution transmission electron microscopy (TEM) and immuno-TEM report the novel escape
Objective: To characterise a Chlamydio trachomatis variant strain from a patient with non-gonococcal urethritis (NGU) whose first void urine (FVU) displayed discrepant C trachomatis test results and describe the clinical response to treatment. Methods: The FVU specimen was assayed with an immune based Chlamydio Rapid Test (CRT) and various nucleic acid amplification tests (NAATs) to establish C trachomatis infection. Sequencing of the major outer membrane protein gene (omp I also known as ompA) was undertaken to identify the serovar of the variant strain. Polymerase chain reaction (PCR) analysis was also conducted to determine whether the strain harboured deletions in the cryptic plasmid or was plasmid free. Results: The FVU specimen was strongly reactive in CRT but negative with the plasmid based Amplicor PCR (Roche) and ProbeTec ET (Becton-Dickinson) assays. However, NAATs for 16S RNA (Aptima Combo 2, GenProbe), omp 1 (RealArt CT PCR, Artus and in-house NAATs) or the outer membrane complex B ...
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
The mechanistic details of the pathogenesis of Chlamydia, an obligate intracellular pathogen of global importance, have eluded scientists due to the scarcity of traditional molecular genetic tools to investigate this organism. Here we report a chemical biology strategy that has uncovered the first essential protease for this organism. Identification and application of a unique CtHtrA inhibitor (JO146) to cultures of Chlamydia resulted in a complete loss of viable elementary body formation. JO146 treatment during the replicative phase of development resulted in a loss of Chlamydia cell morphology, diminishing inclusion size, and ultimate loss of inclusions from the host cells. This completely prevented the formation of viable Chlamydia elementary bodies. In addition to its effect on the human Chlamydia trachomatis strain, JO146 inhibited the viability of the mouse strain, Chlamydia muridarum, both in vitro and in vivo. Thus, we report a chemical biology approach to establish an essential role for
TY - JOUR. T1 - Older partners not associated with recurrence among female teenagers infected with Chlamydia trachomatis. AU - Kissinger, Patricia. AU - Clayton, John L.. AU - OBrien, Megan E.. AU - Kent, Charlotte. AU - Whittington, William L.H.. AU - Oh, M. Kim. AU - Fortenberry, Dennis. AU - Hillis, Susan E.. AU - Litchfield, Billy. AU - Bolan, Gail A.. AU - Handsfield, H. Hunter. AU - Farley, Thomas A.. AU - Berman, Stuart. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Background: Chlamydia trachomatis-infected female teenagers with older partners may be less likely to discuss the infection with their partner(s) and to use condoms and therefore may be more likely to get reinfected. Goal: To determine if C trachomatis-infected female teenagers with older partners were more likely to be reinfected than those with same-aged partners. Study Design: Females aged 14 years to 18 years who had uncomplicated chlamydial infection, were nonpregnant, attended clinics in five United States cities from June 1995 to ...
Goat polyclonal antibody raised against Chlamydia trachomatis MOMP. Native purified MOMP from Chlamydia trachomatis strain L2. (PAB13907) - Products - Abnova
The natural course of sexually transmitted infections caused by Chlamydia trachomatis varies between individuals. In addition to parasite and host effects, the vaginal microbiota might play a key role in the outcome of C. trachomatis infections. Interferon-gamma (IFN-γ), known for its anti-chlamydial properties, activates the expression of indoleamine 2,3-dioxygenase (IDO1) in epithelial cells, an enzyme that catabolizes the amino acid L- tryptophan into N-formylkynurenine, depleting the host cells pool of tryptophan. Although C. trachomatis is a tryptophan auxotroph, urogenital strains (but not ocular strains) have been shown in vitro to have the ability to produce tryptophan from indole using the tryptophan synthase (trpBA) gene. It has been suggested that indole producing bacteria from the vaginal microbiota could influence the outcome of Chlamydia infection. We used two in vitro models (treatment with IFN-γ or direct limitation of tryptophan), to study the effects of direct rescue by the addition
The aim of this study was to evaluate how patients with Chlamydia trachomatis infection perceived the legal enforcement of partner notification and to seek their views on legislation impinging on their own sexual behaviour. The investigation was performed at STD clinics in Stockholm, Sweden in 1997. Consecutive patients (n=192) answered a questionnaire about sexual behaviour and contact tracing. More men (40%) than women (21%) had had sexual intercourse during the past 6 months with an occasional partner. The mean number (6 months prior to this) was 2.3 partners (1-15) for men and 2.2 partners (1-21) for women. Eighteen per cent admitted to having avoided disclosing the name of their partner(s). Ninety per cent considered it beneficial that chlamydial infection was regulated and that a named partner could be forced to undergo STD testing. Partly based on this report, the government has recommended police enforcement to be removed from the legislation as a tool for contact tracing in chlamydial ...
The NATtrol Chlamydia trachomatis serotype D, External Run Control, Medium from Zeptometrix Inc. supplied next week by Genprice is the best reagent! The catalog number is NATCT(D-UW3)-ERCM and the price is 338 EUR.. ...
Expansion microscopy (ExM) is a novel tool to improve the resolution of fluorescence-based microscopy that has not yet been used to visualize intracellular pathogens. Here we show the expansion of the intracellular pathogen Chlamydia trachomatis, enabling to differentiate its two distinct forms, catabolic active reticulate bodies (RB) and infectious elementary bodies (EB), on a conventional confocal microscope. We show that ExM enables the possibility to precisely locate chlamydial effector proteins, such as CPAF or Cdu1, within and outside of the chlamydial inclusion. Thus, we claim that ExM offers the possibility to address a broad range of questions and may be useful for further research on various intracellular pathogens.
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The results of this study indicate that consistent condom use is significantly associated with a 90% reduction in the prevalence of C trachomatis infection among those with known exposure to an infected partner. The present analyses provide a more refined estimate than previously reported by restricting the analyses to a single infection, C trachomatis, and by restricting the sample population to only those who reported exposure to infection. Indeed, our estimate exceeds others (90% effective v 26% to 58% effective), perhaps because our estimate was undiluted by the inclusion of people who do not contribute meaningful observations to the analyses-namely, individuals who may not have been exposed to C trachomatis; their condom use would not be expected to provide protection. While our estimate is greater than the one estimated by Warner and colleagues who also only included contacts to infected people, the substantial overlap of the 95% confidence intervals indicates they are indeed quite ...
Chlamydia trachomatis infection and sexual behaviour among female students attending higher education in the Republic of Ireland. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.s profile, publications, research topics, and co-authors
Assessing a Potential Role of Host Pannexin 1 during Chlamydia trachomatis Infection. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
We included 15 trials (involving 1754 women) although our meta-analyses were based on fewer numbers of studies/women. All of the included studies were undertaken in North America from 1982 to 2001. Two studies were low risk of bias in all domains, all other studies had varying risk of bias. Four other studies were excluded and one study is ongoing.. Eight comparisons were included in this review; three compared antibiotic (erythromycin, clindamycin, amoxicillin) versus placebo; five compared an antibiotic versus another antibiotic (erythromycin, clindamycin, amoxicillin, azithromycin). No study reported different antibiotic regimens.. Microbiological cure (primary outcome) Antibiotics versus placebo: Erythromycin (average risk ratio (RR) 2.64, 95% confidence interval (CI) 1.60 to 4.38; two trials, 495 women; I2 = 68%; moderate-certainty evidence), and clindamycin (RR 4.08, 95% CI 2.35 to 7.08; one trial, 85 women; low-certainty evidence) were associated with improved microbiological cure ...
Chlamydia trachomatis (CT) is the causative infectious agent for a variety of diseases in men: urethritis, proctitis, conjunctivitis, epididymitis, and Reiters Syndrome. Among woman, the consequences of chlamydial infections are severe if left untreated; CT infection can cause urethritis, cervicitis, conjunctivitis, endometritis, salpingitis (with subsequent infertility or ectopic pregnancy) and perihepatitis. Infants from infected mothers can develop conjunctivitis, pharyngitis, and pneumonia.. Chlamydia trachomatis (CT) is the most commonly diagnosed and reported sexually transmitted bacterial infection in Canada. The number of reported cases in Canada in 2006 was , 65,000 (202 per 100,000) and has been increasing annually. This, however, is an underestimate as the disease is often asymptomatic and therefore undiagnosed. CT infections are more common among females between the ages of 15-24 and young men aged 20-29.. Genital infections caused by Chlamydia trachomatis often go unrecognized as ...
Chlamydia trachomatis (CT) is the causative infectious agent for a variety of diseases in men: urethritis, proctitis, conjunctivitis, epididymitis, and Reiters Syndrome. Among woman, the consequences of chlamydial infections are severe if left untreated; CT infection can cause urethritis, cervicitis, conjunctivitis, endometritis, salpingitis (with subsequent infertility or ectopic pregnancy) and perihepatitis. Infants from infected mothers can develop conjunctivitis, pharyngitis, and pneumonia.. Chlamydia trachomatis (CT) is the most commonly diagnosed and reported sexually transmitted bacterial infection in Canada. The number of reported cases in Canada in 2006 was , 65,000 (202 per 100,000) and has been increasing annually. This, however, is an underestimate as the disease is often asymptomatic and therefore undiagnosed. CT infections are more common among females between the ages of 15-24 and young men aged 20-29.. Genital infections caused by Chlamydia trachomatis often go unrecognized as ...
Since publication of CDCs 1993 guidelines (CDC. Recommendations for the prevention and management of Chlamydia trachomatis infections, 1993. MMWR 1993;42[No. RR-12]:1--39), nucleic acid amplification tests (NAATs) have been introduced as critical new tools to diagnose and treat C. trachomatis and Neisseria gonorrhoeae infections. NAATs for C. trachomatis are substantially more sensitive than previous tests. When using a NAAT, any sacrifice in performance when urine is substituted for a traditional swab specimen is limited, thus reducing dependence on invasive procedures and expanding the venues where specimens can be obtained. NAATs can also detect both C. trachomatis and N. gonorrhoeae organisms in the same specimen. However, NAATs are usually more expensive than previous tests, making test performance from an economic perspective a key consideration. This report updates the 1993 guidelines for selecting laboratory tests for C. trachomatis with an emphasis on screening men and women in the ...
Among 830 women attending a clinic for sexually transmitted disease, Chlamydia trachomatis was isolated from 180(22%)and Neisseria gonorrhoeae from 84 (10%). Retrospective analysis showed that 43 of the women were given outpatient treatment for acute pelvic inflammatory disease because they had low abdominal pain, deep dyspareunia, or unusual vaginal bleeding, or all of these, for less than 2 months in association with cervical motion or adnexal tenderness, or both. None had adnexal masses. C. trachomatis was isolated from 22 and N. gonorrhoeae from 15 of this subgroup of 43 women. This presentation of pelvic inflammatory disease occurred in 10 of the 37 women in the whole study with both C. trachomatis and N. gonorrhoeae, 12 of 143 women with C. trachomatis alone, five of 47 women with N. gonorrhoeae alone, and 16 of 603 women with neither organism. Thus, in North America, C. trachomatis is associated with a syndrome usually diagnosed as mild pelvic inflammatory disease and managed on an ...
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has ...
Chlamydia trachomatis is an obligate intracellular human pathogen causing ocular and urogenital infections that are a significant clinical and public health concern. This bacterium uses a type III secretion (T3S) system to manipulate host cells, through the delivery of effector proteins into their cytosol, membranes, and nucleus. In this work, we aimed to find previously unidentified C. trachomatis T3S substrates. We first analyzed the genome of C. trachomatis L2/434 strain for genes encoding mostly uncharacterized proteins that did not appear to possess a signal of the general secretory pathway and which had not been previously experimentally shown to be T3S substrates. We selected several genes with these characteristics and analyzed T3S of the encoding proteins using Yersinia enterocolitica as a heterologous system. We identified 23 C. trachomatis proteins whose first 20 amino acids were sufficient to drive T3S of the mature form of β-lactamase TEM-1 by Y. enterocolitica. We found that 10 of these
OLIVEIRA, Francisca Laís Araújo de et al. Use of different Taq DNA polymerases for detection of Chlamydia trachomatis in cervical samples. Rev Pan-Amaz Saude [online]. 2015, vol.6, n.4, pp.19-24. ISSN 2176-6223.. INTRODUCTION: Chlamydia trachomatis is a small gram-negative bacterium sexually transmitted, which progresses asymptomatically in the majority of infected people, causing long-term damage mainly in the female reproductive system. The polymerase chain reaction (PCR) has been the diagnostic method most widely used in recent epidemiological studies by presenting superior sensitivity than the other sensitivity tests. For a good performance of PCR, the choice of enzymes is very important because they have different characteristics that influence their performance. OBJECTIVE: To analyze and compare the detection of C. trachomatis using three commercial enzymes Taq DNA polymerases in 280 cervical samples. METHODS: The enzymes used were: Taq DNA Polymerase Recombinant (Invitrogen, USA), ...
Problem: Chlamydia trachomatis is a significant worldwide health problem, and the often-asymptomatic disease can result in infertility. To develop a successful vaccine, a complete understanding of the immune response to chlamydial infection and development of genital tract pathology is required. Method of Study We utilized the murine genital model of chlamydial infection. Mice were immunized with chlamydial major outer membrane protein, and vaginal lavage was assessed for the presence of neutralizing antibodies. These samples were then pre-incubated with Chlamydia muridarum and administered to the vaginal vaults of immune-competent female BALB⁄ c mice to determine the effect on infection. Results The administration of C. muridarum in conjunction with neutralizing antibodies reduced the numbers of mice infected, but a surprising finding was that this accelerated the development of severe oviduct pathology. Conclusion Antibodies play an under-recognized role in chlamydial infection and pathology
Chlamydia antibodies are antibodies targeting bacteria of the Chlamydia genus, but it generally refers specifically to antibodies targeting Chlamydia trachomatis, which is the cause of Chlamydia infection in humans. Testing for Chlamydia antibodies is not the mainstay diagnostic tool for Chlamydia infection, which is preferentially diagnosed by Nucleic acid amplification tests (NAAT) such as polymerase chain reaction (PCR). However, testing for Chlamydia antibodies is a cost-effective screening device in detecting fallopian tube pathology, as it is often related to Chlamydia infection. The preferred technique for this purpose is by micro-immunofluorescence (MIF), because it is superior in the assessment of tubal pathology when compared with immunofluorescence (IF) or enzyme-linked immunosorbent assay (ELISA). Kodaman PH, Arici A, Seli E (June 2004). Evidence-based diagnosis and management of tubal factor infertility. Current Opinion in Obstetrics and Gynecology. 16 (3): 221-9. ...
Background: Tests available for molecular diagnosis of chlamydial infections detect Chlamydiatrachomatis, but do not find other Chlamydia species associated with genital, ophthalmic, cardiovascular, respiratory or neurological diseases. The routine detection of all Chlamydia species would improve the prognosis of infected people and guide therapeutic choices.. Aim: To design and validate a sensitive, specific, reproducible, inexpensive and easy-to-perform assay to quantify most Chlamydia species.. Methods: Primers and probe were selected using the gene coding for the 16S rRNA. The detection limits were assessed for suspensions of Chlamydia trachomatis, Chlamydia psittaci and Chlamydia pneumoniae. The performance of this test was compared with that of two commercial kits (Amplicor-Roche and Artus) on 100 samples obtained from children with trachoma.. Results: The detection capacities for Chlamydia trachomatis of the broad-range real-time polymerase chain reaction (PCR) were similar or slightly ...
Chlamydia infections in women - MedHelps Chlamydia infections in women Center for Information, Symptoms, Resources, Treatments and Tools for Chlamydia infections in women. Find Chlamydia infections in women information, treatments for Chlamydia infections in women and Chlamydia infections in women symptoms.
What Is LGV? LGV (Lymphogranuloma venereum) is a sexually transmitted disease (STD) caused by three strains of the bacterium Chlamydia trachomatis. The ...
Genitourinary chlamydia infection, Chlamydia trachomatis infection, Chlamydiasis, Genitourinary chlamydia infection, Genital chlamydia infection. Authoritative facts from DermNet New Zealand.
Chlamydia trachomatis bacteria, coloured transmission electron micrograph (TEM). These spherical bacteria (orange and green) are human parasites and live only inside host human cells and cause various types of genital, eye and lymph node infections. These infections include sexually transmitted diseases, non-specific urethritis (NSU) and lymphogranuloma venereum (enlarged lymph glands). The bacteria also cause trachoma eye disease, a leading cause of blindness. Treatment is with antibiotics. Magnification: x26000 when printed 10 centimetres wide. - Stock Image C002/5595
TY - JOUR. T1 - Antigenic analysis of the chlamydial 75-kilodalton protein. AU - Zhong, G.. AU - Brunham, R. C.. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 1992. Y1 - 1992. N2 - Both B- and T-cell immunogenicity of a chlamydial 75-kDa protein was analyzed by using 131 partially overlapped decapeptide homologs of the 75-kDa protein from Chlamydia trachomatis serovar L2. Six rabbit antiserum specimens raised with serovars B, C, and L2 were used to assay the antibody reactivities of the decapeptides. Seventy-five of the 131 decapeptides were recognized by at least one antiserum specimen, and two peptides were found to be immunodominant and surface accessible on native organisms. The same set of decapeptides were cleaved from the pins and tested for their T-cell- stimulating activity in an in vitro proliferation assay. A single decapeptide was able to stimulate proliferation of chlamydial antigen-primed lymph node T cells from BALB/c mice.. AB - Both B- and T-cell ...
achat Doxycycline belgique 500mg pour la chlamydia acheter Doxycycline vente vidalia vente doxycycline 100mg cm- 100mg onglet.2 - Chlamydia trachomatis; 1.2. Le choix de première intention est lazithromycine (Zithromax). doxycycline (100 mg 2 fois/j.Linfection à Chlamydia Trachomatis est devenue 50à 80 fois plus fréquente que la gonococcie et représente la première maladie bactérienne sexuellement.Lazithromycine est un antibiotique très efficace utilisé pour un certain nombre dinfections bactériennes, y compris le traitement de la chlamydia. Doxycycline.Lazithromycine est à privilégier car il sagit du. Une antibioprophylaxie monodose par doxycycline après piqûre de tique a été démontrée comme étant.. Les pénicillines, les cyclines (dont la doxycycline),. doxycycline 100 mg x 2/ j pdt 7 jours ou ttt minute anti chlamydia: Azithromycine 1 g per os.Pour en savoir plus sur la chlamydia, cette IST, les causes,. La Chlamydia peut être traitée par ces deux antibiotiques: la ...
Fujibio Chlamydia Rapid Test Kit intended for in vitro diagnostic use in the rapid, qualitative detection of Chlamydia trachomatis directly from female endocervical swab and male urethral swab, in addition to ocular specimens from symptomatic patients. The test is intended for use as an aid in the diagnosis of Chlamydia infections.. The one step Chlamydia test is a rapid qualitative immunoassay based on the immunochromatographic principle. (In the assay procedure, a clinical specimen is obtained and place into an extraction tube containing extraction solution. A. after two minutes. Extraction Solution B is added to the tube. 3 drops (approximately 150 ul) of extracted samples is added to the sample well).. The membrane is pre-coated with anti-genus specific lipopolysaccharide (LPS) monoclonal antibody on the test band (T) region and goat anti-mouse antibody on the control band (C) region. During testing, the sample is allowed to react with the colloidal gold particles which have been coated with ...
Chlamydia trachomatis & Neisseria gonorrhoeae DNA Probe,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
We traced the Chlamydia trachomatis L2b variant in Amsterdam and San Francisco. All recent lymphogranuloma venereum cases in Amsterdam were caused by the L2b variant. This variant was also present in the 1980s in San Francisco. Thus, the current out ...
TY - JOUR. T1 - Viable Bacterial Load Is Key to Azithromycin Treatment Failure in Rectally Chlamydia trachomatis Infected Women (FemCure). AU - Dukers-Muijrers, Nicole H. T. M.. AU - Wolffs, Petra F. G.. AU - de Vries, Henry J. C.. AU - Götz, Hannelore M.. AU - Janssen, Kevin. AU - Hoebe, Christian J. P. A.. PY - 2019/9/13. Y1 - 2019/9/13. UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072234660&origin=inward. UR - https://www.ncbi.nlm.nih.gov/pubmed/31107956. U2 - 10.1093/infdis/jiz267. DO - 10.1093/infdis/jiz267. M3 - Letter. C2 - 31107956. VL - 220. SP - 1389. EP - 1390. JO - Journal of Infectious Diseases. JF - Journal of Infectious Diseases. SN - 0022-1899. IS - 8. ER - ...
The overall aim of this study was to establish molecular techniques for the detection and identification of difficult to grow - bacteria in mixed bacterial populations in clinical samples without the need for culturing procedures.. Material and Methods: Thirty-nine strains of Mobiluncus were used as a model system for phylogenetic classification of fastidious bacteria based on 16S ribosomal DNA (rDNA) sequences. To test the application of the 16S rDNA broad range PCR concept for detecting bacteria clinically, urine samples spiked with Chlamydia trachomatis elementary bodies and real urine test samples from 12 C. trachomatis positive and negative male volunteers were tested in a semiblind manner against routine procedures. Furthermore, gastric biopsy samples from 22 individuals (13 defined as having Helicobacter pylori-associated gastritis, and 9 defined as normal controls) were evaluated for the presence of Helicobacter 16S rDNA and the virulence genes cagA, vacA, and ureA. PCR products were ...
Data for competition of the seven β-lactam antibiotics with [3H]benzylpenicillin for the three PBPs are presented in Table 1. As the PBP assay is based on competitive binding, these data are expressed as 50% inhibitory concentrations (IC50s), i.e., the concentration of β-lactam required to inhibit subsequent binding of [3H]benzylpenicillin by 50% (2, 4, 5). The only quantitative PBP binding data previously reported for C. trachomatis RBs concern the binding of benzylpenicillin, where IC50s of 0.03 μg/ml (PBP1), 0.006 μg/ml (PBP2), and 0.003 μg/ml (PBP3) were reported (1). For benzylpenicillin we observed a similar range of IC50s, with no more than a sixfold difference in affinity between the individual PBPs.. Studies with other bacteria, particularly theEnterobacteriaceae and Pseudomonas aeruginosa, have indicated that the killing target or targets for a particular β-lactam are usually represented by those PBPs that are most readily saturated by the antibiotic (2, 4, 5, 23). On this basis, ...
When people go for either a Chlamydia test or a Gonorrhea test, they always go for a combined Chlamydia and Gonorrhea test.. The main reason for that is that both the tests are quite similar. Additionally, Chlamydia symptoms are very similar to Gonorrhea symptoms, so its only wise to test for both infections together to ascertain the exact type of infection.. This test is called the Nucleic Acid Amplification Test or NAAT. Both Chlamydia and Gonorrhea are caused by bacteria. When somebody is infected with these bacteria, theres supposed to be the presence of the bacteria in the urine sample.. Chlamydia and Gonorrhea Test Window Period is generally 3 to 7 days. It means 3 to 7 days after the infection period the detection of the individual bacteria can be done positively. In most of the cases people come for a test much after that, but if youre not among them then its better that you wait for at least 7 to 10 days.. The NAAT test carries out an amplification of the DNA of the bacteria and ...
Lymphogranuloma venereum (LGV) is an infectious contagious disease of inflammatory and invasive nature of the urogenital tract that is caused by Chlamydia trachomatis. In many parts of the world, VLG has become an important cause of anogenital disease among men who have sex with other men 41.. LGV is caused by invasive serotypes L1, L2 and L3 of Chlamydia trachomatis in contrast with serotypes A-C of this agent, which cause ocular infection, such as trachoma, and the more common serotypes D-K that cause genital infections 42.. Epidemiology. LGV is a relatively rare disease in industrialized countries, but it is endemic in parts of Africa, Asia, South America and the Caribbean 43. The incidence of infection by Chlamydia trachomatis after sexual contact is unknown, but probably it is smaller than gonorrhea and canchroid. The peak of incidence of the infection is between the second and third decades of life, the most active period of the sexual life. The period of sexual transmissibility in ...
This test was performed using the APTIMA® COMBO2 Assay (GEN-PROBE).. Clinical Significance. C. trachomatis infections are the leading cause of sexually transmitted diseases in the United States. C. trachomatis is known to cause cervicitis, pelvic inflammatory disease (PID), epididymitis and proctitis. It is also the most frequent cause of non-gonococcal urethritis in men. Among women, the consequences of Chlamydial infections are severe if left untreated. Approximately half of Chlamydial infections are asymptomatic.Neisseria gonorrhoeae (gonococci) is the causative agent of gonorrhea. In men, this disease generally results in anterior urethritis accompanied by purulent exudate. In women, the disease is most often found in the cervix, but the vagina and uterus may also be infected.. Alternative Name(s) CT/NG APTIMA®, CT/GC APTIMA®, Hologic, CT/GC TMA, CT/NG TMA. ...
Know about Chlamydia Symptoms In Women. The bacteria exclusively enter the body sexually through the warm moist skin of the mouth, penis or in the rectum.
Chlamydia species are obligate intracellular bacteria that infect a broad range of mammalian hosts. Members of related genera are pathogens of a variety of vertebrate and invertebrate species. Despite the diversity of Chlamydia, all species contain an outer membrane lipooligosaccharide (LOS) that is comprised of a genus-conserved, and genus-defining, trisaccharide 3-deoxy-D-manno-oct-2-ulosonic acid Kdo region. Recent studies with lipopolysaccharide inhibitors demonstrate that LOS is important for the C. trachomatis developmental cycle during RB- > EB differentiation. Here, we explore the effects of one of these inhibitors, LPC-011, on the developmental cycle of five chlamydial species. Sensitivity to the drug varied in some of the species and was conserved between others. We observed that inhibition of LOS biosynthesis in some chlamydial species induced formation of aberrant reticulate bodies, while in other species, no change was observed to the
The late chlamydial inclusion membrane is not derived from the endocytic pathway and is relatively deficient in host proteins.: Chlamydiae are obligate intracel
Global Chlamydia Infection Industry 2022 Market Research Report Purchase This Report by calling ResearchnReports.com at +1-888-631-6977.. This report is a compressive analysis of every situation of Chlamydia Infection market. With precise investigation of the past situation, present market scenario and future anticipated progress has been offered in this report respectively. Exact data of the prime strategies, market share values and products of the key leading companies is stated apprehensively.. Download sample pages of this report: https://www.researchnreports.com/request_sample.php?id=62526 It provides accurate outline if Chlamydia Infection market depending on the key parameters such as applications, end users, products, regions and many other sub segmentations. Estimated growth by volume and revenue with respect to the global market for Chlamydia Infection over the future years has been mentioned in detail.. An additional deals into the major geographical segmentations of this particular ...
Lymphogranuloma venereum (LGV) is an uncommon sexually transmitted disease (STD) caused by Chlamydia trachomatis. LGV is endemic in certain areas of Africa, Southeast Asia, India, the Caribbean, and South America.
1. National Health and Medical Research Council. The Australian Immunisation Handbook. 8th edn. Canberra; 2003.. 2. National Centre in HIV Epidemiology and Clinical Research. HIV/AIDS, viral hepatitis and sexually transmissible infections in Australia. Annual surveillance report, 2007. Sydney: University of New South Wales; 2007.. 3. Heymann D, editor. Control of Communicable Diseases Manual. 18th edn. Washington: American Public Health Association; 2004.. 4. OzFoodNet Working Group. Monitoring the incidence and causes of diseases potentially transmitted by food in Australia: Annual Report of the OzFoodNet Network, 2006. Commun Dis Intell 2007;31:345-363.. 5. Hocking J, Fairley C, Counahan M, Crofts N. The pattern of notification and testing for genital Chlamydia trachomatis infection in Victoria, 1998-2000: an ecological analysis. Aust N Z J Public Health 2003;27:405-408.. 6. Chen M, Fairley C, Donovan B. Nowhere near the point of diminishing returns: correlations between chlamydia testing and ...
Pelvic inflammatory disease or pelvic inflammatory disorder (PID) is an infection of the upper part of the female reproductive system namely the uterus, fallopian tubes, and ovaries, and inside of the pelvis. Often there may be no symptoms. Signs and symptoms, when present may include lower abdominal pain, vaginal discharge, fever, burning with urination, pain with sex, or irregular menstruation. Untreated PID can result in long term complications including infertility, ectopic pregnancy, chronic pelvic pain, and cancer. The disease is caused by bacteria that spread from the vagina and cervix. Infections by Neisseria gonorrhoeae or Chlamydia trachomatis are present in 75 to 90 percent of cases. Often multiple different bacteria are involved. Without treatment about 10 percent of those with a chlamydial infection and 40 percent of those with a gonorrhea infection will develop PID. Risk factors are similar to those of sexually transmitted infections generally and include a high number of sexual ...
Lymphogranuloma venereum is a sexually transmitted condition that is caused by the L1, L2 and L3 serotypes of Chlamydia trachomatis, which is an obligate intracellular bacterial agent. The condition is most commonly observed in tropical and subtropical regions of the world, although recently outbreaks in Europe and North America were observed.
Chlamydia trachomatis genital tract infections remain a significant national and global health problem that is especially important in womens reproductive heal...
Key words: maxillary sinusitis, etiology, microbiological tests. Otorynolaryngologia, 2002, 1 (3), 187-189. Chlamydia pneumoniae. 3, 4. Candida albicans. Journal of clinical microbiology 2005; 43 (9): 4914-5. 2005: Friedek d; Romanik m; Ekiel a; Chelmicki z; Martirosian g Occurrence of chlamydial cervicitis in.European Society of Clinical Microbiology and Infectious Diseases. Zas, ujemny posiew krwi, w kale. Inne bakterie w pochwie-Chlamydia pneumoniae.Chlamydia pneumoniae oraz wiru-sów należących do czterech ro-teriology and Applied Microbiology. The. World of microbes. Abstracts, Paris.. Obecności Chlamydia trachomatis i/lub Mycoplasma hominis Ureaplasma urealyticum. bcm Microbiology, 2005; 5: 61; Reid g. Bruce a. w. Selection of.Everett k. d. Chlamydia and Chlamydiales: more than meets the eye. Vet. bmc Microbiology 2004, 4, 48-59. 16. Greub g. Raoult d. Crescent bodies of.Non-authorized microbiology lectures notices ad 1996. Version 0. 1. Dzieci i dorośli 5-40 lat-wirusy: Mycoplasma, ...
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While Chlamydia trachomatis has been known to cause sexually transmitted genital infection for a number of years, economical and practical diagnostic methods were not available to physicians until recently. Recent innovations in Chlamydia testing have made test results much more accurate than had been true previously. Figure Chl1 shows the change in the number of reported cases from 1996 to 2000. Changes in testing methods may account for the increase in the number of reported cases in 2000 and will play an even greater role in year 2001 data, when even more accurate tests become available. Increases also occur as screening sites funded through the Indiana State Department of Health (ISDH) are added to the program, giving more women the opportunity to be tested for Chlamydia.. There is a higher prevalence of Chlamydia in females; however, these data must be interpreted with caution, because Chlamydia screening programs preferentially test females. This is largely due to the screening of young ...
Chlamydia is the second most common sexually transmitted diseases after papillomavirus. It affects both men and women but is more serious consequence at the fair sex.. Chlamydia causes severe irreversible damage to reproductive organs in women. The infection is the cause of clogging and blockage of the fallopian tubes, causing serious consequences such as infertility and creating conditions for the emergence of dangerous conditions such as the ectopic pregnancy.. Chlamydia trachomatis is transmitted through all forms of sex - vaginal, oral, anal. In most cases, the infection is symptomless - seven out of 10 people do not complain of any signs weeks after infection. If you are experiencing any symptoms, they include unusual vaginal discharge, burning during urination, possible rectal pain, anal spread of microorganisms, discharges and even bleeding from the rectum.. There are several types of antibiotic treatment in chlamydial infection. In one is considered a single dose of medicament, other ...
The target population is 18- to 24-year-old women because they have the highest incidence of Ct infection in the general population and because screening programmes implemented in other European countries (systematic or opportunistic, i.e., in STI clinics) target this age group. Our study population is, however, restricted to students. In France they represent a large part of this age group. This choice represents an issue in terms of the generalisability of our results. However, this choice was motivated by the fact that UHS have seen their missions reinforced in terms of prevention and care and are likely to play a role in offering Ct screening in the future, including for non-student females. In fact, four of five UHS have already or are in the process of becoming health centres (not limited to students, but localised in universities and with a special mission towards the student population). Another issue regarding the generalisability of our results is the enrolment of voluntary ...
Vulval cancer may also present with pruritus or pain. For a patient who presents with these symptoms and where cancer is not immediately suspected, it is reasonable to use a period of treat, watch and wait as a method of management. However, this should include active follow-up until symptoms resolve or a diagnosis is confirmed. If symptoms persist, the referral may be urgent or non-urgent, depending on the symptoms and the degree of concern about cancer ...
Chlamydia trachomatis: 5 days after birth to 2 weeks (late onset - C. trachomatis has a longer incubation period) Untreated ... "Chlamydia trachomatis". In: Red Book: 2015 Report of the Committee on Infectious Diseases, 30th, Kimberlin DW (Ed), Elk Grove ... most commonly Neisseria gonorrhoeae or Chlamydia trachomatis. Antibiotic ointment is typically applied to the newborn's eyes ... Babies infected with chlamydia may develop pneumonitis (chest infection) at a later stage (range 2-19 weeks after delivery). ...
Miller KE (April 2006). "Diagnosis and treatment of Chlamydia trachomatis infection". Am Fam Physician. 73 (8): 1411-6. PMID ...
Neisseria gonorrhoeae and Chlamydia trachomatis), and normal fauna of the genitourinary tract (e.g., Candida albicans) are ... "Vertical Transmission of Chlamydia trachomatis in Chongqing China". Current Microbiology. 58 (4): 315-320. doi:10.1007/s00284- ... Chlamydia HIV Human T-lymphotropic virus Syphilis Zika fever, caused by Zika virus, can cause microcephaly and other brain ... Chlamydia infection, Ureaplasma urealyticum, and human papillomavirus) S - Syphilis The signs and symptoms of a vertically ...
Less commonly, Chlamydia spp. may be the cause. Bacteria such as Chlamydia trachomatis or Moraxella spp. can cause a ... Inclusion conjunctivitis of the newborn is a conjunctivitis that may be caused by the bacterium Chlamydia trachomatis, and may ... People who wear contact lenses and those whose infection is caused by gonorrhea or chlamydia should be treated. Allergic cases ... have disease which is thought to be due to chlamydia or gonorrhea, have a fair bit of pain, or have copious discharge. ...
Testing pregnant women for Group B Streptococcus and Chlamydia trachomatis, and administering antibiotic treatment, if needed, ... Darville T (October 2005). "Chlamydia trachomatis infections in neonates and young children". Seminars in Pediatric Infectious ... Exposure to birds is associated with Chlamydia psittaci; farm animals with Coxiella burnetti; aspiration of stomach contents ... Mycoplasma, Legionella, Streptococcus, and Chlamydia can also be detected using PCR techniques on bronchoalveolar lavage and ...
Diener-West, Marie (1998). "Incident Chlamydia trachomatis Infections Among Inner-city Adolescent Females". JAMA. 280 (6): 521- ... Burstein, Gale R. (1998). "JAMA Network , JAMA , Incident Chlamydia trachomatis Infections Among Inner-city Adolescent Females ...
Chlamydia trachomatis can also contribute to development of corneal ulcer. Superficial ulcers involve a loss of part of the ... Among them are bacteria, fungi, viruses, protozoa, and chlamydia: Bacterial keratitis is caused by Staphylococcus aureus, ...
Infections by Neisseria gonorrhoeae or Chlamydia trachomatis are present in 75 to 90 percent of cases. Often, multiple ... Chlamydia trachomatis Neisseria gonorrhoeae Prevotella spp. Streptococcus pyogenes Prevotella bivia Prevotella disiens ... Chlamydia trachomatis and Neisseria gonorrhoeae are usually the main cause of PID. Data suggest that PID is often polymicrobial ... Globally about 106 million cases of chlamydia and 106 million cases of gonorrhea occurred in 2008. The number of cases of PID; ...
Chlamydia pneumoniae Chlamydia trachomatis (Chlamydia) Clostridium difficile Cyclospora cayetanensis Dengue virus Dientamoeba ... November 2001). "Features of Chlamydia trachomatis and Neisseria gonorrhoeae infection in male Army recruits". J. Infect. Dis. ... "Prevalence and high rate of asymptomatic infection of Chlamydia trachomatis in male college Reserve Officer Training Corps ... Müller J, Møller DS, Kjaer M, Nyvad O, Larsen NA, Pedersen EB (2003). "Chlamydia pneumoniae DNA in peripheral blood mononuclear ...
Chlamydia trachomatis is the most common cause of reactive arthritis following urethritis. Ureaplasma and mycoplasma are rare ... The most common triggering infection in the US is a genital infection with Chlamydia trachomatis. Other bacteria known to cause ... with Chlamydia trachomatis); however, it also can happen after group A streptococcal infections. It most commonly strikes ... In Norway between 1988 and 1990, the incidence was 4.6 cases per 100,000 for chlamydia-induced reactive arthritis and 5 cases ...
"Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor". Clin Diagn Lab Immunol. 10 (3 ... chronic chlamydia infection, possibly pemphigus DR4-DQ4(DRB1*0405:DQB1*0401) is associated with: autoimmune pancreatitis, ...
... is generally the visible result of lymphogranuloma venereum, lymphatic infection by Chlamydia trachomatis. This ...
... reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infection". The Lancet. 358 (9296): 1851- ...
Chlamydia is caused by the sexually transmitted bacteria Chlamydia trachomatis which infects the genitals. It more commonly ... 3]Chlamydia - CDC Fact Sheet. Restrepo, B.; Cardona-Maya, W. (October 2013). "Antisperm antibodies and fertility association". ...
... and Chlamydia trachomatis. One study has shown that men with MAGI who have lower serum levels of total testosterone tend to ...
Tang Fei-fan, a medical microbiologist best known for culturing the Chlamydia trachomatis agent in the yolk sacs of eggs. Yang ...
... results from the experiment led to the inclusion of amoxicillin as one of the recommended treatments for Chlamydia trachomatis ... the early 1990s indicated that amoxycillin was an appropriate treatment for genital infections caused by Chlamydia trachomatis ... of a screening algorithm for the diagnosis of genital infections with Neisseria gonorrhoeae and Chlamydia trachomatis among ...
Patient-Delivered Partner Therapy for [[Chlamydia trachomatis and Neisseria gonorrhoeae: Interim Guidance for Medical Providers ... is the practice of treating the sex partners of people diagnosed with chlamydia or gonorrhea by providing prescriptions or ...
Different genomic segments encoding for several Chlamydia trachomatis pathogen's proteins, including MOMP, OmcB, and PompD, are ... Gas vesicle gene can be exploited as a delivery vehicle to generate a potential vaccine for Chlamydia. Limitations of this ... In vitro assessments of cells show expression of the Chlamydia genes on cell surfaces through imagining techniques and show ... Childs TS, Webley WC (September 2012). "In vitro assessment of halobacterial gas vesicles as a Chlamydia vaccine display and ...
Another cause of neonatal CAP is Chlamydia trachomatis, which, though acquired at birth, does not cause pneumonia until two to ...
... and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains. Mol Biol Evol. 1993 Nov;10(6):1327-42. Smith ...
... the dengue virus and chlamydia trachomatis among others. Lipid droplets are composed of a neutral lipid core consisting mainly ...
... populations Recommended for immunisation programmes with certain characteristics Infections due to Chlamydia trachomatis or ...
Mycoplasma genitalium and hominis and Chlamydia trachomatis infections. PBMCs may be also susceptible to viral infections. ...
Men who meet the criteria for urethritis commonly get Nucleic Acid Amplification Testing (NAAT) for Chlamydia trachomatis and ... Non-gonococcal urethritis (caused by Chlamydia trachomatis): The CDC recommends administering an oral single dose of ... Upper-middle income countries had the highest prevalence of chlamydia. The rate of chlamydia is around two times higher in ... most commonly caused by Chlamydia trachomatis, which is accounted for 20-50% of routinely tested cases. NGU, sometimes called ...
In the post-war decades, the laboratory broadened its scope to study chlamydia trachomatis and transmissible spongiform ...
... such as Chlamydia trachomatis or Chlamydophila pneumoniae. Amann, Rudolf; Springer, Nina; Schönhuber, Wilhelm; Ludwig, Wolfgang ... Their analyses showed that P. acanthamoebae has an 86 to 87% sequence similarity with bacteria in the Chlamydia genus. It had a ... After analyzing the genome and confirming 86% 16S rRNA gene sequence identity to members of the genus Chlamydia, they proposed ... This species has shown to have over eighty percent 16S rRNA gene sequencing identity with the class Chlamydiae. Parachlamydia ...
He had a daughter, He Lian, who was married to Tang Fei-fan, a virologist best known for culturing the Chlamydia trachomatis ...
In sexually active men, Chlamydia trachomatis is responsible for two-thirds of acute cases, followed by Neisseria gonorrhoeae ... In those who are young and sexually active gonorrhea and chlamydia are frequently the underlying cause. In older males and men ... The treatment of choice is often azithromycin and cefixime to cover both gonorrhoeae and chlamydia. Fluoroquinolones are no ... especially the various chlamydiae. For cases caused by enteric organisms (such as E. coli), ofloxacin or levofloxacin are ...
... which are better tolerated by the eye and more effective against Chlamydia trachomatis in addition to N. gonorrhea. In 2001, ...
Chlamydia trachomatis: 5 days after birth to 2 weeks (late onset - C. trachomatis has a longer incubation period)[1] ... "Chlamydia trachomatis". In: Red Book: 2015 Report of the Committee on Infectious Diseases, 30th, Kimberlin DW (Ed), Elk Grove ... or a bacterial infection such as Neisseria gonorrhoeae or Chlamydia trachomatis.[1] ... Babies infected with chlamydia may develop pneumonitis (chest infection) at a later stage (range 2-19 weeks after delivery). ...
Chlamydiae (Chlamydia psittaci, Chlamydia trachomatis). *Radioresistant micrococci and relatives *Deinococcus group ( ... Chlamydiae. Deinococcus-Thermus. Fusobacteria. Gemmatimonadetes. Nitrospirae. Planctomycetes-Verrucomicrobia/Chlamydiae (PVC ...
Chlamydia trachomatis[27]. *Coxiella burnetii[28]. *Ehrlichia[29]. *Leptospira. *Listeria[30]. *Mycobacterium tuberculosis[31] ...
Chlamydia trachomatis can also contribute to development of corneal ulcer.. Superficial ulcers involve a loss of part of the ... Among them are bacteria, fungi, viruses, protozoa, and chlamydia: *Bacterial keratitis is caused by Staphylococcus aureus, ...
... a Chlamydia trachomatis or Neisseria gonorrhoeae infection may be the cause.[9][43] These infections are typically classified ... Chlamydia trachomatis and Mycoplasma genitalium can infect the urethra but not the bladder.[26] These infections are usually ...
Bacteria such as Chlamydia trachomatis or Moraxella spp. can cause a nonexudative but persistent conjunctivitis without much ... Inclusion conjunctivitis of the newborn is a conjunctivitis that may be caused by the bacterium Chlamydia trachomatis, and may ... People who wear contact lenses and those whose infection is caused by gonorrhea or chlamydia should be treated.[2] Allergic ... have disease which is thought to be due to chlamydia or gonorrhea, have a fair bit of pain, or have copious discharge.[11] ...
Chlamydia trachomatis. *Chlamydiae. *Chlorobi. *Chromobacterium violaceum. *Clostridium acetobutylicum. *Clostridium botulinum ...
Chlamydia. *Chlamydia trachomatis *Chlamydia. *Lymphogranuloma venereum. *Trachoma. Bacteroidetes. *Bacteroides fragilis. * ...
Chlamydia. *Chlamydia trachomatis *Chlamydia. *Lymphogranuloma venereum. *Trachoma. Bacteroidetes. *Bacteroides fragilis. * ...
Chlamydia trachomatis bakterien blir for første gang kultivert (i eggeplommesekken) av Feifan Tang og kollegaer.[5] ... advances in the diagnostic isolation of Chlamydia, including TRIC agent, from the eye, genital tract, and rectum». British ...
Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma Inguinale (Klebsiella granulomatis). * ...
Chlamydia trachomatis. *Chlamydiae. *Chlorobi. *Chromobacterium violaceum. *Clostridium acetobutylicum. *Clostridium butyricum ...
Chlamydiae (Chlamydia psittaci, Chlamydia trachomatis). *Radioresistant micrococci and relatives (now commonly referred to as ... Chlamydiae[edit]. Main article: Chlamydiae. The Chlamydiae (diderms, weakly Gram negative) is a phylum of the PVC superphylum. ... The PVC group (now called Planctobacteria) includes Chlamydiae, Lentisphaerae, candidate phylum Omnitrophica, Planctomycetes, ...
"Chlamydia trachomatis infection in female partners of circumcised and uncircumcised adult men". Am J Epidemiol. 162 (9): 907- ...
Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma Inguinale (Klebsiella granulomatis). * ...
... which employs a hybridization protection assay to distinguish Chlamydia trachomatis infections.[14] Various detection and ...
Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma Inguinale (Klebsiella granulomatis). * ...
A clamidia é unha doenza de transmisión sexual causada pola bacteria Chlamydia trachomatis. Nas mulleres os síntomas poden ir ... "Chlamydia Infections: MedlinePlus". Nlm.nih.gov. Consultado o 2013-06-30.. *↑ http://www.webmd.com/genital-herpes/guide/genital ... "Chlamydia trachomatisand Genital Mycoplasmas: Pathogens with an Impact on Human Reproductive Health". Journal of Pathogens ...
For infections due to Chlamydia trachomatis or Neisseria gonorrhoeae *^ Or homatropine (hydrobromide) or cyclopentolate ( ...
Chlamydia trachomatis is the most common cause of reactive arthritis following urethritis. Ureaplasma and mycoplasma are rare ... The most common triggering infection in the US is a genital infection with Chlamydia trachomatis. Other bacteria known to cause ... with Chlamydia trachomatis).[7]. It most commonly strikes individuals aged 20-40 years of age, is more common in men than in ... In Norway between 1988 and 1990, the incidence was 563.3 cases per 100,000 for chlamydia-induced reactive arthritis and 5 cases ...
Ginocchio C, Chapin K (2012). "Prevalence of Trichomonas vaginalis and coinfection with Chlamydia trachomatis and Neisseria ... Prevalence and Incidence of Selected Sexually Transmitted Infections, Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis ...
Chlamydia trachomatis és un bacteri paràsit intracel·lular estricte dels humans i una de tres espècies del gènere Chlamydia.[1] ... Chlamydia». MicrobeWiki, 15-08-2006. [Consulta: 27 octubre 2008]. *↑ Budai, I «Chlamydia trachomatis: milestones in clinical ... Diagnosis of Chlamydia trachomatis Infection (en anglès). A: Chlamydia. Chapter 17 (Mares, M; Ed.) IntechOpen, 2012; Mar 30, pp ... Chlamydia trachomatis. C. trachomatis cossos d'inclusió (en marró) en un cultiu cel·lular de McCoy. ...
... lular Chlamydia trachomatis, que no sembla tenir cap gen involucrat en les vies de síntesi o de recuperació ni del NAD+ ni del ...
މިއީ ކްލަމީޑިއާ ޓްރެކޮމެޓިސް(Chlamydia trachomatis) އޭ ކިޔާ ޖަރާސީމެއްގެ ސަބަބުން ޖިންސީ ގުނަވަނަށް ޖެހޭ ބައްޔެކެވެ. ހޫނު ގަދަ ...
Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma Inguinale (Klebsiella granulomatis). * ...
Chlamydia (Chlamydia trachomatis). *Granuloma inguinale or (Klebsiella granulomatis). *Gonorrhea (Neisseria gonorrhoeae) o sa ... Chlamydia: Ito ay epektibong magagamot ng mga antibiotiko kapag ito ay natukoy. Ang kasalukuyang mga antibiotiko para dito ang ...
Lymphogranuloma venereum (LGV) (Chlamydia trachomatis serotype L1, L2, L3 Bkz.Chlamydia) ...
Aínda máis sorprendente é o patóxeno intracelular Chlamydia trachomatis, que no seu xenoma carece de candidatos reconocibles ...
Only listed for single‐dose treatment of genital Chlamydia trachomatis and of trachoma ...
... wherein the Chlamydia trachomatis antigens to be determined are coated or adsorbed on the solid phase. ... The present disclosure relates to a solid phase immunoassay for the detection of Chlamydia trachomatis antigens in a clinical ... Chlamydia trachomatis LGV Type II strain Tang, Chlamydia trachomatis Trachoma serotype A strain HAR-13, Chlamydia trachomatis ... a) lysing Chlamydia trachomatis cells in the specimen to release Chlamydia trachomatis antigen; ...
... Designation: Trachoma type K strain UW-31/Cx Application: Note that activities with high ... TRIC type K, a new immunologic type of Chlamydia trachomatis. J. Immunol. 113: 591-596, 1974. PubMed: 4210884 ... Feed with fresh growth medium containing FBS prescreened for Chlamydia antibodies and 1-2 ug/mL cycloheximide. Incubate at 37°C ...
... Designation: Apache-2 Application: Sexually Transmitted Disease Research ... Chlamydia trachomatis Serovar Ba (ATCC® VR-347™) Classification: Chlamydiaceae, Chlamydia / Product Format: frozen 1 mL per ... Chlamydia trachomatis Serovar Ba ATCC® VR-347™ frozen 1 mL per vial ... FBS used to culture Chlamydia must be prescreened to verify that the serum does not contain antibodies to Chlamydia or other ...
The etiological diagnosis of what is today known as infection by Chlamydia trachomatis was first made possible in 1907 when ... Chlamydia trachomatis / isolation & purification*, physiology. Cricetinae. Cycloheximide / pharmacology. Female. Humans. ... The etiological diagnosis of what is today known as infection by Chlamydia trachomatis was first made possible in 1907 when ... C. trachomatis was originally classified as a virus, and the culture systems used were those for viruses. Macchiavello was the ...
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia/Chlamydophila group; Chlamydia. Data source. GenBank (Assembly: ... Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical ...
Genital C trachomatis infection is broadly distributed throughout the sexually active population, with a substantial reservoir ... Epidemiology of genital Chlamydia trachomatis in England and Wales Genitourin Med. 1997 Apr;73(2):122-6. doi: 10.1136/sti.73.2. ... Objective: To describe the recent epidemiology of genital Chlamydia trachomatis infection in England and Wales. ... Methods: Numbers of new cases of genital C trachomatis infection, obtained from the Department of Health and Welsh Office, were ...
Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour ... Treatment of genital Chlamydia trachomatis infection in pregnancy. What is the issue? ... Chlamydia trachomatis is a bacterial infection which is sexually transmitted. It is more common in younger women. Women may ... Interventions for treating genital chlamydia trachomatis infection in pregnancy. *Use of antiviral drugs in late pregnancy for ...
no history of chlamydia infection Women who self-reported no history of cervical infection with Chlamydia trachomatis ... history of chlamydia infection Women who self-reported a history of cervical infection with Chlamydia trachomatis ... chlamydia. healthy women. history of endocervical chlamydia. no history of endocervical chlamydia. ... Chlamydia trachomatis is the most common sexually transmitted bacterial disease. Untreated endocervical C. trachomatis ...
In a perspective based on historic and geographic patterns of Chlamydia trachomatis, Patrik M. Bavoil, PhD, professor at the ... Behavior of Chlamydia trachomatis May Increase Risks of Female Infertility. February 6, 2018 ... Chlamydia is the most frequently reported bacterial genital infectious disease in women in the United States and may be ... Furthermore, rectal C. trachomatis may chronically or episodically contaminate and/or infect the female lower genital tract, ...
... Journal. Sexually Transmitted ...
Chlamydia trachomatis (strain D/UW-3/Cx). Chlamydia trachomatis. Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM ... Chlamydia psittaci 02DC14. Chlamydia psittaci 01DC11. Chlamydia psittaci C1/97. Chlamydia psittaci 84-8471/1. Chlamydia abortus ... Chlamydia trachomatis serovar A (strain A2497). Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B). 516. UniRef90_ ... Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B). Chlamydia trachomatis. 516. UniRef100_B0B7P6. Cluster: ...
Anti-Chlamydia trachomatis MOMP pAb (GTX41698) is tested in Chlamydia trachomatis samples. 100% Ab-Assurance. ... Chlamydia trachomatis MOMP antibody for ELISA, ICC/IF, IHC-Fr. ... of Chlamydia trachomatis strain L2.. Antigen Species. Chlamydia ...
Anti-Chlamydia trachomatis mAb (GTX40767) is tested in Chlamydia samples. 100% Ab-Assurance. ...
Chlamydia trachomatis, genital infections (https://wwwn.cdc.gov/nndss/conditions/chlamydia-trachomatis-genital-infections/) ... Chlamydia Trachomatis Infection , 2010 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chlamydia-trachomatis-infection/ ...
... Genital tract infections with Chlamydia trachomatis are a major ... TABLE 1. Number and rate * of reported cases of Chlamydia trachomatis infection, by state and sex -- United States, 1995 ... Recommendations for the prevention and management of Chlamydia trachomatis infections, 1993. MMWR 1993;42(no. RR-12). ... surveillance data on chlamydia and data on chlamydia test positivity among women screened in family-planning clinics funded ...
Population based screening for asymptomatic Chlamydia trachomatis infection has been postulated since the introduction of ... Screening for Chlamydia trachomatis. BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e4231 (Published 05 July 2012) Cite this as ... of participants were C trachomatis positive at the first invitation and there was only … ...
Chlamydia Trachomatis, Genital Infections , 1996 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chlamydia-trachomatis- ... Chlamydia Trachomatis, Genital Infections , 1995 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chlamydia-trachomatis- ... Chlamydia Trachomatis, Genital Infections , 1990 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chlamydia-trachomatis- ... Chlamydia trachomatis infection (https://wwwn.cdc.gov/nndss/conditions/chlamydia-trachomatis-infection/) ...
Chlamydia trachomatis. These include techniques to identify Chlam ... Mutagenesis of Chlamydia trachomatis Using TargeTron Mary M. ... Chlamydia trachomatis. These include techniques to identify Chlamydia trachomatis in patient samples, ranging from simple point ... Detection of Chlamydia trachomatis and Neisseria gonorrhoeae Using Multiplex Strand Invasion Based Amplification (mSIBA) ... Proximity Labeling of the Chlamydia trachomatis Inclusion Membrane Macy G. Olson, Lisa M. Jorgenson, Ray E. Widner, Elizabeth A ...
UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINE N-ACYLTRANSFERASEBeta-MercaptoethanolPalmitic AcidSulfate IonUridine-Diphosphate-N-Acetylglucosamine
Pathophysiology of Chlamydia Chlamydia trachomatis is the most widespread bacterial agent of STD all over the world. Genital ... Pathophysiology of Chlamydia Chlamydia trachomatis is the most widespread bacterial agent of STD all over the world. Genital ... Chlamydia Trachomatis : The Most Widespread Bacterial Agent Of Std All Over The World. 1475 Words6 Pages ... More about Chlamydia Trachomatis : The Most Widespread Bacterial Agent Of Std All Over The World. ...
Chlamydia trachomatis,Neisseria gonorrhoeae, and Trichomonas vaginalis, NAA. TEST: 183160 Test number copied ... Patient Information: Chlamydia, Gonorrhea, and Trichomoniasis. Protect Your Patients From the Consequences of Untreated ... Chlamydia, Gonorrhea, and Trichomonas: Easily Detected and Easily Treated. Trichomonas vaginalis: Detect More Infections With ...
All about Chlamydia (Chlamydia trachomatis). FACTS: Chlamydia is perhaps the most common of all sexually transmitted diseases, ... Its caused by a bacteria called Chlamydia trachomatis and is passed from person-to-person during unprotected sex.. ... In addition to its venereal impact, Chlamydia trachomatis is also responsible for trachoma, the leading cause of preventable ... In addition to its venereal impact, Chlamydia trachomatis is also responsible for trachoma, the leading cause of preventable ...
C trachomatis infection affects the cervix, urethra, salpinges, uterus, nasopharynx, and epididymis{ref1}{ref2}{ref3}; it is ... C trachomatis)?) and Which medical conditions are caused by Chlamydia trachomatis (C trachomatis)? What to Read Next on ... Which medical conditions are caused by Chlamydia trachomatis (C trachomatis)?. Updated: Sep 25, 2018 ... Role of Chlamydia trachomatis in miscarriage. Emerg Infect Dis. 2011 Sep. 17(9):1630-5. [Medline]. [Full Text]. ...
Do you know which doctor should you consult if you have Chlamydia Trachomatis. This and other commonly asked questions about ... Drugs for Chlamydia Trachomatis. Amoxicillin. This medication is a penicillin-like , β-lactam antibiotic. It is used to treat ... 2. Which Organs can be affected by Chlamydia?. Chlamydia is the most common sexually transmitted disease (STD). It can infect ... If infected and treated for chlamydia infection can there be a recurrence of infection?. Yes, the treatment is not for lifetime ...
... have discovered that Chlamydia is much more diverse than was previously thought. ... Chlamydia trachomatis is the most common sexually transmitted infection (STI) both in the UK and globally, with approximately ... Research highlights risks with current method of tracking Chlamydia trachomatis. Published: 12 March 2012 ... A cell infected with chlamydia. The team found there appeared to be no barriers to the swapping of DNA when circumstances allow ...
A mutant Chlamydia trachomatis variant was detected in Sweden in 2006 and has since also been diagnosed in Norway, but not in ... Mutant Chlamydia trachomatis in Denmark * S Hoffmann1, J S Jensen1 ... A mutant Chlamydia trachomatis variant was detected in Sweden in 2006 and has since also been diagnosed in Norway, but not in ... Mutant Chlamydia trachomatis in Denmark. Euro Surveill. 2007;12(10):pii=738. https://doi.org/10.2807/esm.12.10.00738-en ...
Inoculation of the mouse pneumonitis biovar of Chlamydia trachomatis into the ovarian bursa of mice resulted in salpingitis. An ... Chlamydia trachomatis-induced salpingitis in mice J Infect Dis. 1983 Dec;148(6):1101-7. doi: 10.1093/infdis/148.6.1101. ... Inoculation of the mouse pneumonitis biovar of Chlamydia trachomatis into the ovarian bursa of mice resulted in salpingitis. An ... This model for salpingitis may be useful in understanding some aspects of the pathogenesis of C trachomatis genital infections ...
Chlamydia trachomatis & Neisseria gonorrhoeae DNA Probe,ARUP Laboratories is a national reference laboratory and a worldwide ... MGB Alert Chlamydia pneumoniae ASR*. 7. Chlamydia EIA. 8. Chlamydia IgG. 9. Chlamydia DFA Direct Specimen Collection Kit. 10. ... Chlamydia OIA. 2. Clearview Chlamydia. 3. Pathfinder® Chlamydia DFA. 4. Pathfinder Chlamydia Microplate (EIA Microplate). 5. ... Chlamydia DFA Direct Specimen Test. 11. Chlamydia Antibody Panel, IgG by IFA. ...
Deep sequencing-based discovery of the Chlamydia trachomatis transcriptome.. Albrecht M1, Sharma CM, Reinhardt R, Vogel J, ... Chlamydia trachomatis is an obligate intracellular pathogenic bacterium that has been refractory to genetic manipulations. ... B) Northern analysis of C. trachomatis plasmid transcripts reveals a highly abundant small RNA pL2-sRNA1 of ∼100 nt in length ... A) Length distribution of reads after 5′ end-linker and polyA-tail clipping of four sequenced C. trachomatis cDNA libraries ...
Initial and Repeat Screening for Chlamydia trachomatis During Pregnancy. Alexander D. Allaire,1 John F. Huddleston,2 William L ... Objectives: The objective of this study is to determine the prevalence of Chlamydia trachomatis and risk factors for positive ... Results: The prevalence of C. trachomatis was 14.8%. At initial testing, 10.4% of the women were positive. If the initial test ... trachomatis at Grady Memorial Hospital or a Grady-affiliated clinic between July 1, 1993 and December 31, 1994. We calculated ...
... Abebayehu N. Yilma,1 Shree R. Singh,1 ... Chlamydia trachomatis, the agent of bacterial sexually transmitted infections, can manifest itself as either acute cervicitis, ... Our data demonstrates that naringenin is an immunomodulator of inflammation triggered by C. trachomatis, which possibly may be ... Inflammation induced by C. trachomatis contributes greatly to the pathogenesis of disease. Here we evaluated the anti- ...
Culture for Chlamydia on such nongential specimens can be ordered on the same specimen. If a GC culture is also requested see ...
Diseases : Chlamydia pneumoniae , Chlamydia trachomatis, Pneumonia. Pharmacological Actions : Anti-Bacterial Agents, ... Diseases : Chlamydia trachomatis, Inflammation. Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, ... 4 Abstracts with Chlamydia trachomatis Research. Filter by Study Type. Animal Study. ... Bioactive compounds of Nigella sativa essential oil as antibacterial agents against Chlamydia Trachomatis D.Sep 18, 2019. ...
Metabolism Global and overview maps 01100 Metabolic pathways ...
Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes. W Baehr, Y X Zhang, T Joseph, ... Chlamydia trachomatis is an obligate prokaryotic intracellular pathogen of humans that infects mucosal epithelial cells. ... Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes ... Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes ...
... explains the mechanisms by which the bacterium Chlamydia trachomatis hijacks nutrients of its host to its own benefit. ... How Chlamydia trachomatis hijacks energy stores from its host. Human cells infected with Chlamydia trachomatis. © Institut ... Chlamydia trachomatis is also able to colonize the eye, and the resulting inflammation is the leading cause of blindness by an ... In the case of Chlamydia trachomatis, it is known that the vacuole is rich in glycogen, an energy storage molecule made of ...
  • Untreated endocervical C. trachomatis infections can cause pelvic inflammatory disease (PID), a disorder of the endometrium, fallopian tubes, and adjacent structures that occurs after ascension of the bacterium from the lower to upper genital tract. (clinicaltrials.gov)
  • Vaccine development has been identified as essential for control of C. trachomatis infections, and current evidence suggests that an effective vaccine will likely be based on several C. trachomatis antigens. (clinicaltrials.gov)
  • While approximately 70% of infections with C. trachomatis in young women are asymptomatic, 20% - 40% of these occult infections will progress from endocervical inflammation to the development of PID. (clinicaltrials.gov)
  • Although data from both experimental models and clinical studies suggest that antigen specific CD4+ and CD8+ T cells are required for optimal control of genital tract chlamydial infections, the current lack of information regarding the specific C. trachomatis antigens eliciting protective immune responses in humans hinders vaccine development. (clinicaltrials.gov)
  • Infections caused by the intracellular bacterium Chlamydia trachomatis are a global health burden affecting more than 100 million people annually causing damaging long-lasting infections. (aau.dk)
  • These studies show that persistent C. trachomatis maintains viability for extended periods, illustrate the reversibility of immunologically mediated persistent infections, and characterize reactivation at the ultrastructural and biochemical levels. (asm.org)
  • Chlamydia infections have an immense impact on public health and are associated with diverse disease manifestations including atherosclerosis, blindness, and sterility. (ku.edu)
  • BACKGROUND: In many developing countries, little is known about the prevalence of genital Chlamydia trachomatis infections and complications, such as infertility, thus preventing any policy from being formulated regarding screening for C. trachomatis of patients at risk for infertility. (ugent.be)
  • In conclusion, the diagnosis of asymptomatic chlamydial infections in men can be established with reasonable accuracy by the detection of Chlamydia antigens in urine samples using MicroTrak EIA. (mysciencework.com)
  • Chlamydia trachomatis Infections in the United States What Are They Costing Us? (jamanetwork.com)
  • We estimate that C trachomatis infections cost Americans over $1.4 billion per year in direct and indirect costs. (jamanetwork.com)
  • Reducing the incidence of personal suffering and heavy economic burden imposed by C trachomatis infections requires establishment and maintenance of effective prevention/control programs. (jamanetwork.com)
  • Chlamydia trachomatis serovars D-K are the leading cause of bacterially-acquired sexually transmitted infections in the United States. (etsu.edu)
  • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. (duke.edu)
  • In women C. trachomatis can establish persistent genital infections that lead to pelvic inflammatory disease and sterility. (duke.edu)
  • In contrast to natural infections in humans, experimentally induced infections with C. trachomatis in mice are rapidly cleared. (duke.edu)
  • The cytokine interferon-γ (IFNγ) plays a critical role in the clearance of C. trachomatis infections in mice. (duke.edu)
  • Because IFNγ induces an antimicrobial defense system in mice but not in humans that is composed of a large family of Immunity Related GTPases (IRGs), we questioned whether mice deficient in IRG immunity would develop persistent infections with C. trachomatis as observed in human patients. (duke.edu)
  • We show that the delayed but highly effective clearance of intrauterine C. trachomatis infections in Irgm1/m3((-/-)) mice is dependent on an exacerbated CD4(+) T cell response. (duke.edu)
  • Asymptomatic genital infections due to C. trachomatis represent the major form of chlamydial genital infection in women. (unthsc.edu)
  • Podoore, JK , Holmes, KK & Alexander, ER 1982, ' Asymptomatic urethral infections due to chlamydia trachomatis in male u.s. military personnel ', Journal of Infectious Diseases , vol. 146, no. 6. (unthsc.edu)
  • Feed with fresh growth medium containing FBS prescreened for Chlamydia antibodies and 1-2 ug/mL cycloheximide. (atcc.org)
  • FBS used to culture Chlamydia must be prescreened to verify that the serum does not contain antibodies to Chlamydia or other factors that would interfere with growth. (atcc.org)
  • Reacts with purified elementary antibodies of the E/UW/5, L2/434 and K/UW-31 strains of C. trachomatis. (lsbio.com)
  • The objective of the present study was to determine the prevalence of C. trachomatis and evaluate the diagnostic utility of serological markers namely anti-C. trachomatis IgG and IgA antibodies in women attending an infertility clinic. (ugent.be)
  • Two commercial species-specific ELISA were used to determine serum IgG and IgA antibodies to C. trachomatis and vaginal swabs specimens were tested by PCR. (ugent.be)
  • Chlamydia W4-W5 is suitable for use in ELISA. (acris-antibodies.com)
  • Aims - To develop an indirect ELISA using the heat shock protein (hsp60) of Chlamydia trachomatis as antigen. (elsevier.com)
  • Results - A sensitive and relatively specific ELISA to detect hsp60 has been produced, which can be exploited to determine the antibody response to C trachomatis hsp60. (elsevier.com)
  • McClure, M. O. / Antigen capture ELISA for the heat shock protein (hsp60) of Chlamydia trachomatis . (elsevier.com)
  • Chlamydia trachomatis antibody LS-C524917 is a biotin-conjugated mouse monoclonal antibody to chlamydia trachomatis Chlamydia trachomatis. (lsbio.com)
  • In the article, published in the Journal of Infectious Diseases on Nov. 15, 2017, Bavoil and colleagues present a multifactorial hypothesis based on revising the status of C. trachomatis from "principal pathogen to commensal organism/opportunistic pathogen," which they urge both researchers and clinicians to explore. (infectioncontroltoday.com)
  • The obligate intracellular bacterium Chlamydia trachomatis is a major human pathogen and a main cause of genital and ocular diseases. (duke.edu)
  • Our data suggest that C. trachomatis is not the primary pathogen responsible for tubal pathology in Rwandan women. (ugent.be)
  • Chlamydia trachomatis has emerged as the most common sexually transmitted bacterial pathogen in the United States and is now recognized to cause substantial morbidity. (jamanetwork.com)
  • As an obligate intracellular pathogen, C. trachomatis infects columnar epithelial cells of the genital mucosae and can cause deleterious sequelae such as pelvic inflammatory disease, infertility, and ectopic pregnancy. (etsu.edu)
  • The obligate intracellular pathogen Chlamydia trachomatis is the most common cause of bacterial sexually transmitted diseases in the United States. (duke.edu)
  • Chlamydia trachomatis is a bacterial infection which is sexually transmitted. (cochrane.org)
  • With more than 90 million new cases annually, Chlamydia trachomatis is the most common sexually transmitted bacterial disease. (clinicaltrials.gov)
  • C. trachomatis is an obligate, intracellular, gram-negative microorganism recognized as the most common bacterial sexually transmitted disease worldwide. (clinicaltrials.gov)
  • Chlamydia is the most frequently reported bacterial genital infectious disease in women in the United States and may be asymptomatic or weakly symptomatic. (infectioncontroltoday.com)
  • Cell division in Chlamydiae is poorly understood as apparent homologs to most conserved bacterial cell division proteins are lacking and presence of elongation (rod shape) associated proteins indicate non-canonical mechanisms may be employed. (osti.gov)
  • This term derives from the name of the bacterial genus Chlamydiain the family Chlamydiaceae, order Chlamydiales, class and phylum Chlamydiae. (acris-antibodies.com)
  • IMPORTANCE Chlamydia trachomatis is the leading cause of infectious blindness globally and the most reported bacterial sexually transmitted infection both domestically and internationally. (asm.org)
  • Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and can cause significant reproductive morbidity in women. (uab.edu)
  • It also inhibited intracellular proliferation of Chlamydia trachomatis with a half-minimal inhibitory concentration in the submicromolar range but did not affect the viability of mammalian cells or bacterial species representing benign intestinal microflora. (ingentaconnect.com)
  • Early morning first-void urine collected from 279 sexually active Swedish male recruits (mean age 19.5 years) was tested by two commercial enzyme immunoassay (EIA) kits, MicroTrak and IDEIA III, and by MicroTrak direct fluorescence assay (DFA), to detect Chlamydia trachomatis antigens. (mysciencework.com)
  • HPV and Chlamydia trachomatis were detected simultaneously and genotyped using a highly sensitive bead based assay. (elsevier.com)
  • Conclusions - This assay will permit the future investigation of the immunopathogenesis of persistent inflammation following C trachomatis infection. (elsevier.com)
  • A cross-sectional survey of 1216 newly pregnant women (mean age = 31 years) from 32 general practices and five family planning clinics was conducted to find the prevalence of chlamydial infection and to evaluate self-administered vaginal swabs and first-pass urines for detection of Chlamydia trachomatis by ligase chain reaction assay. (bjgp.org)
  • All of the studies reported on curing chlamydia, based on the elimination of the bacteria, with an antibiotic. (cochrane.org)
  • IFN-gamma-deficient mice, on the other hand, cleared 99.9% of genital Chlamydia within the first 3 wk but then developed systemic disease associated with dissemination of bacteria to multiple organs. (jimmunol.org)
  • Detection of Chlamydia trachomatis antigens in first-void urin. (mysciencework.com)
  • Detection of Chlamydia trachomatis antigens in first-void urine to identify asymptomatic male carriers. (mysciencework.com)
  • Detection of Chlamydia trachomatis infection in early pregnancy using self-administered vaginal swabs and first pass urines: a cross-sectional community-based survey. (bjgp.org)
  • Additionally, our study implicates the Clp system playing an integral role in chlamydial developmental cycle progression, which may help establish models of how Chlamydia spp. (asm.org)
  • Finally, genetic ablation of LDs negatively affected generation of C. trachomatis infectious progeny, consistent with a role for LD biogenesis in optimal chlamydial growth. (duke.edu)
  • Natural infection induces partial immunity to Chlamydia trachomatis Identification of chlamydial antigens that induce interferon γ (IFN-) secretion by T cells from immune women could advance vaccine development. (physiciansweekly.com)
  • Several chlamydial antigens reach the host cell cytosol prior to the natural release of chlamydiae at the end of the developmental cycle. (etsu.edu)
  • The research herein examines the escape and trafficking of the immunodominant chlamydial antigens MOMP, LPS, and cHsp60 within C. trachomatis serovar E-infected polarized human endometrial epithelial cells. (etsu.edu)
  • Collectively, these studies (i) establish a novel escape mechanism for chlamydial antigens, (ii) identify cHsp60-2 as a marker of iron stress response in C. trachomatis , and (iii) define for the first time the host cell ER as a destination for selected chlamydial antigens during infection. (etsu.edu)
  • In addition to its strong association with PID, C. trachomatis infection is also thought to enhance HIV transmission and contribute to human papilloma virus induced cervical neoplasia. (clinicaltrials.gov)
  • Chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (HPV) cofactor in cervical cancer. (elsevier.com)
  • The aim of this study is to evaluate the prevalence of Chlamydia trachomatis and HPV co-infection in different cohorts of asymptomatic women from a Northern Italy area at high incidence for cervical cancer. (elsevier.com)
  • Genital C trachomatis infection is broadly distributed throughout the sexually active population, with a substantial reservoir of asymptomatic infection among those generally perceived to be at low risk of a sexually transmitted infection. (nih.gov)
  • The E.coli derived recombinant 6xHis fusion at C-terminus protein contains Chlamydia Trachomatis MOMP protein epitopes, 191-354 amino acids. (acris-antibodies.com)
  • The current investigation evaluates the events that occur during reactivation of infectious Chlamydia trachomatis from persistently infected cell cultures. (asm.org)
  • In addition, reactivation of infectious organisms from persistent chlamydiae that were maintained in culture for several weeks was demonstrated. (asm.org)
  • The present work identifies the Na + -translocating NADH:ubiquinone oxidoreductase (Na + -NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. (ingentaconnect.com)
  • Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. (jimmunol.org)
  • Mucosal immunity to Chlamydia trachomatis in a mouse model of female genital tract infection is mediated predominantly by Th1-type cells, as shown by in vivo neutralization of cytokines involved in the Th1 vs Th2 pathways. (jimmunol.org)
  • Identification of Chlamydia trachomatis Antigens Recognized by T Cells From Highly Exposed Women Who Limit or Resist Genital Tract Infection. (physiciansweekly.com)
  • There was considerable variation in the prevalence of genital C trachomatis infection detected within different clinical settings, together with a substantial level of asymptomatic infection. (nih.gov)
  • The broad distribution of infection across all sexually active health service attenders and the high level of asymptomatic infection suggest that a new, screening based, approach to the control of genital C trachomatis infection is required. (nih.gov)
  • The prevalence of asymptomatic urethral infection due to C. trachomatis in men is not as welldocumented. (unthsc.edu)
  • Recovery of tryptophan-starved C. trachomatis strain D after rescue with secretions from five ( Chlamydia positive/negative) participants that have different concentrations of indole in their vaginal secretions. (biomedcentral.com)
  • Conclusions: Postal chlamydia screening was feasible, but coverage was incomplete and uptake was modest. (ox.ac.uk)
  • What is the Iso13485 validated Pcr inactivated Dna control or Nattrol for Chlamydia trachomatis serotype D, External Run Control, Low (6 X 1 ml/vial)? (orthopractic.org)
  • The NATtrol Chlamydia trachomatis serotype D, External Run Control, Medium from Zeptometrix Inc. supplied next week by Genprice is the best reagent! (orthopractic.org)
  • To determine the frequency and magnitude of Th1 cytokine responses elicited to C. trachomatis infection in humans, we stimulated peripheral blood mononuclear cells from 90 chlamydia-infected women with C. trachomatis elementary bodies, Pgp3, and major outer membrane protein and measured IFN-γ-, tumor necrosis factor alpha (TNF-α)-, and interleukin-2 (IL-2)-producing CD4+ and CD8+ T-cell responses using intracellular cytokine staining. (uab.edu)
  • Chlamydia trachomatis is an obligate intracellular bacterium that undergoes a complex developmental cycle in which the bacterium differentiates between two functionally and morphologically distinct forms, the elementary body (EB) and reticulate body (RB), each of which expresses its own specialized repertoire of proteins. (asm.org)
  • Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells. (duke.edu)
  • Antigen Trafficking within Chlamydia trachomatis -Infected Polarized Human Endometrial Epithelial Cells. (etsu.edu)
  • Giles, David Kelley, "Antigen Trafficking within Chlamydia trachomatis -Infected Polarized Human Endometrial Epithelial Cells. (etsu.edu)
  • These findings indicate that the absence of the predominant murine innate effector mechanism restricting C. trachomatis growth inside epithelial cells results in a compensatory adaptive immune response, which is at least in part driven by CD4(+) T cells and prevents the establishment of a persistent infection in mice. (duke.edu)
  • Treatment of chlamydia infection with antibiotics appears to be effective during pregnancy. (cochrane.org)
  • We conclude that well-designed studies of appropriate sample size, in different settings, are needed to further assess the effects of treatment of chlamydia infection in pregnancy. (cochrane.org)
  • This proposal details an exploratory identification of the antigen-specific cell mediated immune responses associated with antecedent C. trachomatis infection in women. (clinicaltrials.gov)
  • In summary, the predominant Th1 cytokine response elicited to C. trachomatis infection in women was a CD4+ TNF-α response, not CD4+ IFN-γ, and a subset of the CD4+ TNF-α-positive cells produced a second Th1 cytokine. (uab.edu)
  • A prospective study of Kenyan commercial sex workers found that production of interferon-gamma (IFN-γ) by peripheral blood cells stimulated with chlamydia heat-shock protein (HSP60) strongly correlated with protection against incident C. trachomatis infection. (clinicaltrials.gov)
  • Chlamydia W4-W5 protein was purified by proprietary chromatographic technique. (acris-antibodies.com)
  • These observations point out to Chlamydia-mediated manipulation of LDs in infected cells, which may impact the function and thereby the protein composition of these organelles. (duke.edu)
  • Hence, they suggest that to safeguard public health, clinicians should be encouraged to go beyond the traditional sampling of urogenital sites by expanding screening for C. trachomatis to rectal and, when appropriate, pharyngeal sites in sexually active adults. (infectioncontroltoday.com)
  • The authors observe that C. trachomatis transmitted via the fecal-oral or genital-oral routes may colonize gastrointestinal (GI) tract sites without symptoms. (infectioncontroltoday.com)
  • An indirect but compelling argument that supports the idea that C. trachomatis colonizes the GI tract without clinical disease is that most, if not all, other Chlamydia species are first and foremost innocuous gut commensals" in their hosts, the authors state. (infectioncontroltoday.com)
  • Furthermore, rectal C. trachomatis may chronically or episodically contaminate and/or infect the female lower genital tract, exacerbating host responses and contributing to reproductive sequelae. (infectioncontroltoday.com)
  • A sobering thought is that with oral sex and GI tract colonization, C. trachomatis may have 'evolved' yet another, most unsophisticated way to elude the clinician, the infected patient, and the patient's own immune system," observe Bavoil and co-authors. (infectioncontroltoday.com)
  • Since serological testing for Chlamydia shows an excellent negative predictive value for lower genital tract infection, specific peptide-based serological assays may be of use for screening in low prevalence settings. (ugent.be)
  • Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing. (genome.jp)
  • In vitro rescue of genital strains of Chlamydia trachomatis from interferon-γ and tryptophan depletion with indole-positive, but not indole-negative Prevotella spp. (biomedcentral.com)
  • Adverse outcomes secondary to C. trachomatis-induced PID include tubal infertility, ectopic pregnancy, and chronic pelvic pain. (clinicaltrials.gov)
  • Objective: To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. (ox.ac.uk)