Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Relating to the size of solids.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Holmium. An element of the rare earth family of metals. It has the atomic symbol Ho, atomic number 67, and atomic weight 164.93.
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.

Mode of action of chitin deacetylase from Mucor rouxii on N-acetylchitooligosaccharides. (1/1030)

The mode of action of chitin deacetylase from the fungus Mucor rouxii on N-acetylchitooligosaccharides with a degree of polymerization 1-7 has been elucidated. Identification of the sequence of chitin oligomers following enzymatic deacetylation was verified by the alternative use of two specific exo-glycosidases in conjunction with HPLC. The results were further verified by 1H-NMR spectroscopy. It was observed that the length of the oligomer is important for enzyme action. The enzyme cannot effectively deacetylate chitin oligomers with a degree of polymerization lower than three. Tetra-N-acetylchitotetraose and penta-N-acetylchitopentaose are fully deacetylated by the enzyme, while in the case of tri-N-acetylchitotriose, hexa-N-acetylchitohexaose and hepta-N-acetylchitoheptaose the reducing-end residue always remains intact. Furthermore, the enzyme initially removes an acetyl group from the nonreducing-end residue of all chitin oligomers with a degree of polymerization higher than 2, and further catalyses the hydrolysis of the following acetamido groups in a processive fashion. The results are in agreement with the mode of action that the same enzyme exhibits on partially deacetylated water soluble chitosan polymers.  (+info)

Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. (2/1030)

The Saccharomyces cerevisiae CHS7 gene encodes an integral membrane protein located in the ER which is directly involved in chitin synthesis through the regulation of chitin synthase III (CSIII) activity. In the absence of CHS7 product, Chs3p, but not other secreted proteins, is retained in the ER, leading to a severe defect in CSIII activity and consequently, to a reduced rate of chitin synthesis. In addition, chs7 null mutants show the yeast phenotypes associated with a lack of chitin: reduced mating efficiency and lack of the chitosan ascospore layer, clear indications of Chs7p function throughout the S. cerevisiae biological cycle. CHS3 overexpression does not lead to increased levels of CSIII because the Chs3p excess is retained in the ER. However, joint overexpression of CHS3 and CHS7 increases the export of Chs3p from the ER and this is accompanied by a concomitant increase in CSIII activity, indicating that the amount of Chs7p is a limiting factor for CSIII activity. Accordingly, CHS7 transcription is increased when elevated amounts of chitin synthesis are detected. These results show that Chs7p forms part of a new mechanism specifically involved in Chs3p export from the ER and consequently, in the regulation of CSIII activity.  (+info)

Modification of chitosan to improve its hypocholesterolemic capacity. (3/1030)

Cholestyramine is the most widely used bile acid sequestrant in the treatment of hypercholesterolemia. However, cholestyramine has unpleasant side effects as a consequence of its hydrophobic backbone. Therefore, high-capacity bile acid sequestering biopolymers with cationic chitosan derivatives were developed, because electrostatic interactions are important for binding with bile acid anions. Dialkylaminoalkylation and reductive amination of chitosan were done to add dialkylaminoalkyl and an additional free amino group at a hydroxyl site in the chitosan backbone respectively and the amino-derivatized chitosan derivatives were quaternized with methyl iodide to produce a cationic polyelectrolyte. The in vitro bile acid binding capacity of the chitosan derivatives in aqueous NaCl was measured by reversed-phase HPLC. The binding capacities of sodium glycocholate (a major bile acid) to chitosan, DEAE-chitosan, quaternized DEAE-chitosan, and cholestyramine were 1.42, 3.12, 4.06, and 2.78 mmol/g resin, respectively. With quaternized DEAE-chitosan, the bile acid binding capacity increased approximately 50% over that of cholestyramine. The bile acid binding capacity of dialkylaminoalkyl chitosan derivatives increased with the number of carbons in the alkyl groups, indicating that hydrophobic interaction is a secondary factor for the sequestration of bile acids.  (+info)

Development of bacterial contamination during production of yeast extracts. (4/1030)

Baker's yeast suspensions having bacterial populations of 10(6) and 10(8) CFU/ml were subjected to autolysis processes designed to obtain yeast extracts (YE). The bacterial contaminants added to the yeast cell suspensions were produced with spent broths obtained from a commercial yeast production plant and contained 59% cocci (Leuconostoc, Aerococcus, Lactococcus) as well as 41% bacilli (Bacillus). Autolyses were conducted at four different pH levels (4.0, 5.5, 7.0, and 8.5) and with two autolysis-promoting agents (ethyl acetate and chitosan). Processing parameters were more important than the initial bacterial population in the development of contaminating bacteria during manufacture of YE. Drops in the viable bacterial population after a 24-h autolysis were observed when pH was adjusted to 4.0 or when ethyl acetate was added. A significant interaction was found between the effects of pH and autolysis promoters on the bacterial population in YE, indicating that the activity of ethyl acetate, as opposed to that of chitosan, was not influenced by pH.  (+info)

Oligogalacturonic acid and chitosan reduce stomatal aperture by inducing the evolution of reactive oxygen species from guard cells of tomato and Commelina communis. (5/1030)

Stomatal opening provides access to inner leaf tissues for many plant pathogens, so narrowing stomatal apertures may be advantageous for plant defense. We investigated how guard cells respond to elicitors that can be generated from cell walls of plants or pathogens during pathogen infection. The effect of oligogalacturonic acid (OGA), a degradation product of the plant cell wall, and chitosan (beta-1,4-linked glucosamine), a component of the fungal cell wall, on stomatal movements were examined in leaf epidermis of tomato (Lycopersicon esculentum L.) and Commelina communis L. These elicitors reduced the size of the stomatal aperture. OGA not only inhibited light-induced stomatal opening, but also accelerated stomatal closing in both species; chitosan inhibited light-induced stomatal opening in tomato epidermis. The effects of OGA and chitosan were suppressed when EGTA, catalase, or ascorbic acid was present in the medium, suggesting that Ca(2+) and H(2)O(2) mediate the elicitor-induced decrease of stomatal apertures. We show that the H(2)O(2) that is involved in this process is produced by guard cells in response to elicitors. Our results suggest that guard cells infected by pathogens may close their stomata via a pathway involving H(2)O(2) production, thus interfering with the continuous invasion of pathogens through the stomatal pores.  (+info)

Maintenance of CD34 expression during proliferation of CD34+ cord blood cells on glycosaminoglycan surfaces. (6/1030)

Recent studies have indicated that glycosaminoglycan (GAG) interactions with hematopoietic progenitors play a significant role in the regulation of hematopoiesis. However, the details of these interactions are not clear. In this study, we examined the role of soluble and immobilized GAGs in the proliferation of CD34+ cells. Chitosan, a cationic polysaccharide, was used to immobilize GAGs in ionic complex membranes. The GAGs studied were heparin, hyaluronate, and chondroitin sulfates A, B, and C. CD34-enriched umbilical cord blood cells were seeded onto tissue culture plates coated with the GAG-chitosan complex membranes. Cultures were maintained in medium supplemented with stem cell factor and interleukin 3 for up to six weeks, during which total and CD34+ cell numbers were determined by flow cytometry. Total cell number expansion ranged from 25-fold to 40-fold after six weeks. However, only heparin and chondroitin sulfate B (CSB) surfaces retained a significant CD34+ fraction. All other surfaces exhibited declines in CD34 expression, with negligible CD34+ percentages remaining after four weeks. In contrast, heparin and CSB surfaces exhibited CD34+ fractions as high as 90% after four weeks. GAG desorption studies indicated that the observed effects were partly mediated by desorbed GAGs in a concentration dependent manner. Subsequent studies showed that sustained high (160 microg/ml) heparin levels had toxic effects, while the same concentration of CSB exhibited more rapid early proliferation of CD34+ cells. In conclusion, this culture system has demonstrated the ability to produce simultaneous proliferation and CD34+ cell enrichment of a partially purified cord blood population by controlling the nature and levels of GAG moieties to which the cells are exposed. The results indicate that specific GAGs can significantly influence the growth and differentiation characteristics of cultured CD34+ cells.  (+info)

Purification, characterization, and gene analysis of a chitosanase (ChoA) from Matsuebacter chitosanotabidus 3001. (7/1030)

The extracellular chitosanase (34,000 M(r)) produced by a novel gram-negative bacterium Matsuebacter chitosanotabidus 3001 was purified. The optimal pH of this chitosanase was 4.0, and the optimal temperature was between 30 and 40 degrees C. The purified chitosanase was most active on 90% deacetylated colloidal chitosan and glycol chitosan, both of which were hydrolyzed in an endosplitting manner, but this did not hydrolyze chitin, cellulose, or their derivatives. Among potential inhibitors, the purified chitosanase was only inhibited by Ag(+). Internal amino acid sequences of the purified chitosanase were obtained. A PCR fragment corresponding to one of these amino acid sequences was then used to screen a genomic library for the entire choA gene encoding chitosanase. Sequencing of the choA gene revealed an open reading frame encoding a 391-amino-acid protein. The N-terminal amino acid sequence had an excretion signal, but the sequence did not show any significant homology to other proteins, including known chitosanases. The 80-amino-acid excretion signal of ChoA fused to green fluorescent protein was functional in Escherichia coli. Taken together, these results suggest that we have identified a novel, previously unreported chitosanase.  (+info)

Characterization of a novel, antifungal, chitin-binding protein from Streptomyces tendae Tu901 that interferes with growth polarity. (8/1030)

The afp1 gene, which encodes the antifungal protein AFP1, was cloned from nikkomycin-producing Streptomyces tendae Tu901, using a nikkomycin-negative mutant as a host and screening transformants for antifungal activity against Paecilomyces variotii in agar diffusion assays. The 384-bp afp1 gene has a low G+C content (63%) and a transcription termination structure with a poly(T) region, unusual attributes for Streptomyces genes. AFP1 was purified from culture filtrate of S. tendae carrying the afp1 gene on the multicopy plasmid pIJ699. The purified protein had a molecular mass of 9,862 Da and lacked a 42-residue N-terminal peptide deduced from the nucleotide sequence. AFP1 was stable at extreme pH values and high temperatures and toward commercial proteinases. AFP1 had limited similarity to cellulose-binding domains of microbial plant cell wall hydrolases and bound to crab shell chitin, chitosan, and cell walls of P. variotii but showed no enzyme activity. The biological activity of AFP1, which represents the first chitin-binding protein from bacteria exhibiting antifungal activity, was directed against specific ascomycetes, and synergistic interaction with the chitin synthetase inhibitor nikkomycin inhibited growth of Aspergillus species. Microscopy studies revealed that fluorescein-labeled AFP1 strongly bound to the surface of germinated conidia and to tips of growing hyphae, causing severe alterations in cell morphogenesis that gave rise to large spherical conidia and/or swollen hyphae and to atypical branching.  (+info)

How is High Molecular Weight Chitosan abbreviated? HMWC stands for High Molecular Weight Chitosan. HMWC is defined as High Molecular Weight Chitosan somewhat frequently.
This research investigated the effect of enzymatically digested low molecular weight (MW) chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan oligosaccharide samples with varying MW were evaluated in vitro for inhibition of rat small intestinal α-glucosidase and porcine pancreatic α-amylase (GO2KA1; <1000 Da, GO2KA2; 1000-10,000 Da, GO2KA3; MW > 10,000 Da). The in vitro results showed that all tested samples had similar rat α-glucosidase inhibitory and porcine α-amylase inhibitory activity. Based on these observations, we decided to further investigate the effect of all three samples at a dose of 0.1 g/kg, on reducing postprandial blood glucose levels in Sprague-Dawley (SD) rat model after sucrose loading test. In the animal trial, all tested samples had postprandial blood glucose reduction effect, when compared to control, however GO2KA1 supplementation had the strongest effect. The glucose peak (Cmax) for GO2KA1 and control was 152 mg/dL and 193 mg/dL,
Various biological effects have been reported for sulfated chitosan oligosaccharides, but the molecular mechanisms of action of their anti-inflammatory effects are still unknown. This study aimed to evaluate the anti-inflammatory effects of sulfated chitosan oligosaccharides and to elucidate the possible mechanisms of action. The results showed that pretreated low molecular weight sulfated chitosan oligosaccharides inhibited the production of nitric oxide (NO) and inflammatory cytokines such as IL-6 and TNF-α in lipopolysaccharide (LPS)-activated RAW264.7 cells. The sulfated chitosan oligosaccharides also suppressed inducible nitric oxide synthase (iNOS), phosphorylation of JNK and translocation of p65, a subunit of NF-κB, into the nucleus by inhibiting degradation of IκB-α. Our investigation suggests sulfated chitosan oligosaccharides inhibit IL-6/TNF-α in LPS-induced macrophages, regulated by mitogen-activated protein kinases (MAPKs) pathways dependent on NF-κB activation.
Objective(s): This study considered the combination of chitosan nanoparticles with antioxidant-antibacterial fraction extracted from Lactobacillus casei and investigation of possible increasing of antibacterial activity of the fraction in hybrid nanoparticle and the effect of the fraction on the stability of chitosan nanoparticles. Methods: Extraction of Antioxidant antibacterial material from Lactobacillus casei supernatant was done by thin layer chromatography fractionation. For determination of antioxidant and antibacterial activity of fraction, DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and Minimum Inhibition Concentration (MIC) by micro-well dilution method was used, respectively. For chitosan nanoparticles (Cs NPs) formation, the ionic gelation method was used and the ratio of Tripolyphosphate pentasodium (TPP): chitosan was optimized. For Antioxidant fraction loaded chitosan nanoparticles, the fraction is physically incorporated into the chitosan nanoparticles. Particle morphology was monitored
Papermaking. The Carboxymethyl Chitosan report does the thorough study of the key industry players to understand their business strategies, annual revenue, company profile and their contribution to the Carboxymethyl Chitosan market share in the United States. Diverse factors of the Carboxymethyl Chitosan industry like the supply chain scenario, industry standards, import/export details are also mentioned in this report.. Key Highlights of the United States Carboxymethyl Chitosan Market 2017 Report:. A Clear understanding of the Carboxymethyl Chitosan market based on growth, constraints, opportunities, feasibility study.. Concise Carboxymethyl Chitosan Market study based on major United States regions.. Analysis of evolving market segments as well as a complete study of existing Carboxymethyl Chitosan market segments.. Before Purchasing, Request Free Sample Copy of the Report Here: http://qyresearch.us/report/united-states-carboxymethyl-chitosan-market-2017/107070/#requestForSample. Furthermore, ...
TY - JOUR. T1 - Preparation of cross-linked chitosan microspheres by spray drying. T2 - Effect of cross-linking agent on the properties of spray dried microspheres. AU - Desai, K. G H. AU - Park, Hyun Jin. PY - 2005/6/1. Y1 - 2005/6/1. N2 - Chitosan microspheres cross-linked with three different cross-linking agents viz, tripolyphosphate (TPP), formaldehyde (FA) and gluteraldehyde (GA) have been prepared by spray drying technique. The influence of these cross-linking agents on the properties of spray dried chitosan microspheres was extensively investigated. The particle size and encapsulation efficiencies of thus prepared chitosan microspheres ranged mainly between 4.1-4.7 μm and 95.12-99.17%, respectively. Surface morphology, % erosion, % water uptake and drug release properties of the spray dried chitosan microspheres was remarkably influenced by the type (chemical or ionic) and extent (1 or 2%w/w) of cross-linking agents. Spray dried chitosan microspheres cross-linked with TPP exhibited ...
The report studies Chitosan Derivatives in Global market Professional Survey 2016 : Size, Share, Trends, Industry Growth, Opportunity, Application, Production, Segmentation, Cost Structure, Company Profile, Product Picture and Specifications during the Forecast period by 2021. Global Chitosan Derivatives Industry 2016is a comprehensive, professional report delivering market research data that is relevant for new market entrants or established players. Key strategies of the companies operaChitosan Derivativesg in the market and their impact analysis have been included in the report. Furthermore, a business overview, revenue share, and SWOT analysis of the leading players in the Chitosan Derivatives market is available in the report.. Combining the data integration and analysis capabilities with the relevant findings, the report has predicted strong future growth of the Chitosan Derivatives market in all its geographical and product segments. In addition to this, several significant variables that ...
The aim of the present paper is to evaluate the effect of the high molecular weight chitosan (HMWC) and of sodium alginate (NaAL) on surface hydrophobicity of Candida albicans and on adhesion of the yeast to epithelial cells and fibroblasts of different proceeding. For this study, a collection strain and seven isolates of C. albicans from saliva (patients with denture stomatitis) were grown in Sabouraud glucose agar supplemented with HMWC or NaAL or in absence of them (control). Hydrophobicity was determined by adhesion to hydrocarbons method using two organic media (xylene and chloroform). For adhesion experiments, aqueous suspensions of yeasts were contacted with solutions of biopolymers and different cells (rat and human fibroblasts and epithelial cells Hep-2). The quantification of adhesion was made by optical microscopy. Results: a decrease in hydrophobicity was observed in the presence of HMWC (44%) and of NaAL (82%) when chloroform was employed as organic medium, meanwhile the decreases ...
TY - JOUR. T1 - Solid‐phase modification of chitosan hydrogel membranes and permeability properties of modified chitosan membranes. AU - Kubota, Naoji. AU - Kikuchi, Yasuo. AU - Mizuhara, Yukako. AU - Ishihara, Tatsumi. AU - Takita, Yusaku. PY - 1993/12/5. Y1 - 1993/12/5. N2 - A novel preparation method for modified chitosan membranes was developed. Chitosan hydrogel membranes were prepared by immersing an aqueous acetic acid solution of chitosan in KOH solution and modified with 3,3′‐dithiodipropionic acid (DTPA), which has a functional group that causes the thiol ⟷ disulfide transition through a redox reaction. It was smoothly modified with DTPA even in a solid‐phase modification when carbodiimides were used as the condensing reagents. The chitosan membrane modified with DTPA was reduced with tri‐n‐butyl phosphine (MSH membrane) and then oxidized with iodine (MSS membrane). Permeabilities of KCl, sucrose, and urea through these modified chitosan membranes were investigated. The ...
TY - JOUR. T1 - Improvement of osteoblast functions by sustained release of bone morphogenetic protein-2 (BMP-2) from heparin-coated chitosan scaffold. AU - Yun, Young Pil. AU - Lee, Su Young. AU - Kim, Hak Jun. AU - Song, Jae-Jun. AU - Kim, Sung Eun. PY - 2013/1/1. Y1 - 2013/1/1. N2 - The aim of this study was to investigate the improvement in osteoblast functions by using bone morphogenetic protein-2 (BMP-2) immobilized heparin-coated chitosan scaffolds and comparing it with that using chitosan scaffold or BMP-2/chitosan scaffold in vitro. BMP-2 was released from the heparin-coated chitosan scaffold in a sustained manner compared to that released from the chitosan scaffold. The osteoblast functions of MG-63 cells grown on the chitosan scaffold, the BMP-2/chitosan scaffold, the BMP-2/Hep/chitosan scaffold were investigated by assessing cell proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and gene expression. The results of the in vitro studies demonstrated that MG-63 ...
Title:Betaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy. VOLUME: 10 ISSUE: 5. Author(s):Kunal Jain, R. Suresh Kumar, Sumeet Sood and G. Dhyanandhan. Affiliation:Department of Pharmaceutics, J.S.S College of Pharmacy, Udhagamandalam, India.. Keywords:Betaxolol, glaucoma, chitosan, nanoparticles, ocular delivery.. Abstract:Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and open angle glaucoma are associated with rapid and extensive precorneal loss caused by the drainage and high tear fluid turnover. The present study involved design of mucoadhesive nanoparticulate carrier system containing betaxolol hydrochloride for ocular delivery to improve its corneal permeability and precorneal residence time. Nanoparticles were prepared by spontaneous emulsification method and had a particle size of 168-260nm with zeta potential of 25.2-26.4 mV. The in vitro release studies in simulated tear fluid exhibited ...
Chitosan,Chitosan oligosaccharide,Edible Oligosaccharide,Agriculture Oligosaccharide,Oligosaccharide Liquid,Chitin oligosaccharide,Food grade chitosan,Industrial grade chitosan,Pharma. grade chitosan,Feed grade chitosan,High density chitosan,High MW
Objectives The aim of the present study was to develop miltefosine loaded chitosan nanoparticles (MLCNPs) to enhance the therapeutic efficacy of conventional miltefosine drug and to compare the in vitro activities of both forms of the drug against Leishmania tropica. Methods MLCNPs were...
Get Sample Copy of This Report: http://www.researchnreports.com/request_sample.php?id=43430. Market research reports for the Global Chitosan Derivatives Market included detailed segmentation of international, analysis of supply and demand trends, 5-year forecast of market growth, volumes of historic brand market, analysis of the production, importation and exportation, and transparent market methodology. In-depth studies regarding Global Chitosan Derivatives Market, with data from 2011 and projects of compound annual growth rates (CAGRs) are also used as basis for research. Lastly, there are examinations of the Global demand for the market and profiles of the major players of the industry. With all the data gathered and analyzed using SWOT analysis, there was a clearer picture of the competitive landscape of the Global Chitosan Derivatives Market. Sources for the future market growth were uncovered and outlying competitive threats also surfaced. There was strategic direction eminent in the ...
2.1 Global Chitosan Market Competition by Players/Suppliers. 2.1.1 Global Chitosan Sales and Market Share of Key Players/Suppliers (2012-2017). 2.1.2 Global Chitosan Revenue and Share by Players/Suppliers (2012-2017). 2.2 Global Chitosan (Volume and Value) by Type. 2.2.1 Global Chitosan Sales and Market Share by Type (2012-2017). 2.2.2 Global Chitosan Revenue and Market Share by Type (2012-2017). 2.3 Global Chitosan (Volume and Value) by Region. 2.3.1 Global Chitosan Sales and Market Share by Region (2012-2017). 2.3.2 Global Chitosan Revenue and Market Share by Region (2012-2017). 2.4 Global Chitosan (Volume) by Application. 3 United States Chitosan (Volume, Value and Sales Price). 3.1 United States Chitosan Sales and Value (2012-2017). 3.1.1 United States Chitosan Sales and Growth Rate (2012-2017). 3.1.2 United States Chitosan Revenue and Growth Rate (2012-2017). 3.1.3 United States Chitosan Sales Price Trend (2012-2017). 3.2 United States Chitosan Sales Volume and Market Share by ...
We are expertise in manufacturing chitin, chitosan, chitosan oligosaccharide, carboxymethyl chitosan, chitosan fiber, chitosan acetate, chitosan glutamate, chitosan lactate, etc.,
TY - JOUR. T1 - Adsorption of indomethacin onto chemically modified chitosan beads. AU - Mi, Fwu Long. AU - Shyu, Shin Shing. AU - Chen, Chin Ta. AU - Lai, Juin Yih. PY - 2001/11/23. Y1 - 2001/11/23. N2 - Macroporous chitosan beads used for the immobilization of an anti-inflammatory drug were prepared by the wet phase-inversion method. There are two stages of phase-inversion observed from the cast of chitosan droplet in tripolyphosphate (TPP) aqueous solution. The first stage of phase-inversion is dominated by liquid-liquid demixing and the morphology of the freeze-dried chitosan bead shows a bundle-like porous structure. The following stage of phase-inversion is attributed to the solid-liquid demixing and the morphology of the freeze-dried chitosan bead changes to an interconnected porous structure comprising particulates around the pores. The pore size and porosity of the bead can be varied by altering synthesis conditions, such as initial polymer concentration, and the pH value and ...
Read Recovery of Lipids from Aqueous Dispersions with Chitosan Solutions, Russian Journal of Applied Chemistry on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
TY - JOUR. T1 - Effect of single or combined administration of resistant starch and chitosan oligosaccharides on insulin resistance in rats fed with a high-fat diet. AU - Wang, Junxuan. AU - Si, Xu. AU - Shang, Wenting. AU - Zhou, Zhong Kai. AU - Strappe, Padraig. AU - Blanchard, Christopher. N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Starch. ISSNs: 1521-379X; PY - 2017/7. Y1 - 2017/7. N2 - In this study, rats fed with a high-fat diet were treated with resistant starch (RS), chitosan oligosaccharide (COS), and a combination of these complexes with the aim of determining their effect on controlling blood glucose levels and improving insulin resistance (IR). Scanning electron microscopy (SEM) analysis demonstrated that an outer thin layer of film produced by COS covered the surface of RS granules and resulted in an increased particle size distribution. Cross-linking between RS and COS was confirmed by Fourier transform infrared (FTIR) spectroscopy analysis. ...
This study was carried out to investigate effects of chitosan oligosaccharides and/or beta-glucan addition into diets containing organic zinc on performance and biochemical profiles in broilers. One-day old broiler chicks (n=540) were assigned to six groups for six replicates (15 chicks for each). Chicks in control group were fed basal diet containing soybean meal and corn, and experimental groups were fed diets containing 1% organic zinc (Or center dot Zn) or 0.025% chitosan oligosaccharides (COS) or 0.050% beta-glucan (BG) or 1% Or center dot Zn plus 0.025% COS or 1% Or center dot Zn plus 0.050% BG during 42 days. There were no significant differences between groups for performance (body weight, daily body weight gain, daily feed intake, and feed conversion ratio) during experimental period. Although, there were no differences between all groups for serum total cholesterol, HDL-cholesterol, VLDL-cholesterol, urea, insulin and glucose levels, statistical significances were determined between Or ...
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Abstract. Development of biopolymer-based imaging agents which can access rapidly and provide detailed information about the diseases has received much attention as an alternative to conventional imaging agents. However, development of biopolymer-based nanomaterials for tumor imaging still remains challenging due to their low sensitivity and image resolution. To surmount of these limitations, multimodal imaging agents have been developed, and they were widely utilized for theranostic applications. Herein, iodine containing echogenic glycol chitosan nanoparticles are developed for x-ray computed tomography (CT) and ultrasound (US) imaging of tumor diagnosis. X-ray CT/US dual-modal imaging probe was prepared by following below two steps. First, iodine-contained diatrizoic acid (DTA) was chemically conjugated to the glycol chitosan (GC) for the CT imaging. DTA conjugated GC (GC-DTA NPs) formed stable nanoparticles with an average diameter of 315 nm. Second, perfluoropentane (PFP), a US imaging ...
The predominant therapy for peripheral nerve transection is anastomosis by suture. However, sutures have been known to lead to tissue inflammation, granulomas, and poor functional outcomes. While adhesives offer a promising alternative, fibrin-the predominant bio-glue-can transmit disease. Here we examine a photocrosslinkable chitosan hydrogel for use in surgical therapies for peripheral nerve injury. Prepared by conjugating 4-azidobenzoic acid to amino groups of chitosan using carbodiimide chemistry, this formulation demonstrates a high potential of in-situ photocrosslinking. A 40 mg/mL solution gels under 40 s of UV illumination. This gel is demonstrated to be cytocompatible with neural cell populations and is not acutely toxic to nerve conduction ex vivo. Mechanical testing of nerves anastomosed by this hydrogel had tensile strengths comparable to conventional fibrin glues. These results show chitosan hydrogel to be biocompatible and mechanically suitable for use in nerve repair. Keywords-chitosan;
The effects of pH of medium and molecular weight of chitosan on polyelectrolyte complex (PEC) formation between pectin and chitosan was investigated using capillary viscometry. The intrinsic viscosity of the polymers was determined using Huggins plot. PECs were formed between pectin and chitosan in the pH range 2.9-5.6, but no PEC was formed at pH 1.5. The proportion of pectin in pectin-chitosan PEC varied with pH of the medium due to different levels of ionisation of the polymers and also probably due to the flexibility of pectin molecule. The amount of pectin in the PEC increased with a decrease in pH while that of chitosan increased with an increase in pH of medium. Linear relationships were established between the pH of media used and the weight fraction of pectin required for optimal PEC formation with molecular weight grades of chitosan. Molecular weight of chitosan appeared to have no effect (p,0.05) on the optimal ratio of pectin:chitosan required for PEC formation but intrinsic ...
Two Alteromonas sp. strains isolated from deep seawater were grown to promote the production of exopolysaccharides (EPS, E611 and E805), which were incorporated into chitosan solutions to develop films. The combination of the major marine polysaccharides (chitosan and the isolated bacterial EPS) resulted in the formation of homogenous, transparent, colorless films, suggesting good compatibility between the two components of the film-forming formulation. With regards to optical properties, the films showed low values of gloss, in the range of 5-10 GU, indicating the formation of non-glossy and rough surfaces. In addition to the film surface, both showed hydrophobic character, with water contact angles higher than 100 º, regardless of EPS addition. Among the two EPS under analysis, chitosan films with E805 showed better mechanical performance, leading to resistant, flexible, easy to handle films ...
A process for producing granular porous chitosan of extremely uniform particle size and having uniform fine pores on the spherical surface and cut cross sectional face. The process comprises dissolving a low molecular weight chitosan into an aqueous acidic solution, pouring the solution into a basic solution and thereby coagulating the product to precipitate porous chitosan.
Research is our Passion, Innovation is our Tradition!It gives immense pleasure to share with you all that our faculty published paper on Use of combined nanocarrier system based on chitosan nanoparticles and phospholipids complex for improving delivery of ferulic acid in International Journal of Biological Macromoleculesbl (Elsevier)… Heartiest congratulations to Dr. Darshan Telange ...
Chitosan has been reported to be a non-toxic, biocompatible antibacterial, antifungal and insecticidal agent. In this work the fungistatic efficacy of a set of low polydispersity chitosans varying in molecular weight from 1.2 to 90.0 kDa towards the filamentous palm parasitic fungus Penicillium vermoesenii has been studied in vitro. It has been shown for the first time that the activity of chitosan against the fungus has unusual bell-like dependence on chitosan molecular weight so that chitosans having the molecular weight between 5÷10 kDa possess the highest fungistatic activity while chitosans with both lower and higher molecular weights are significantly less active. (Imprint: Nova Biomedical). ...
Chitosan, a polyaminosaccharide obtained by alkaline deacetylation of chitin, possesses useful properties including biodegradability, biocompatibility, low toxicity, and good miscibility with other polymers. It is extensively used in many applications in biology, medicine, agriculture, environmental protection, and the food and pharmaceutical industries. The amino and hydroxyl groups present in the chitosan backbone provide positions for modifications that are influenced by factors such as the molecular weight, viscosity, and type of chitosan, as well as the reaction conditions. The modification of chitosan by chemical methods is of interest because the basic chitosan skeleton is not modified and the process results in new or improved properties of the material. Among the chitosan derivatives, cyclodextrin-grafted chitosan and poly(ethylene glycol)-grafted chitosan are excellent candidates for a range of biomedical, environmental decontamination, and industrial purposes. This work discusses
Chitosan has many benefits mainly in health and weight reduction. Chitosan is able to reduce triglycerides in the blood because of its ability to bind dietary lipids, thus reducing intestinal lipid absorption. Chitin also has the ability of soaking up fat found in the intestines and flushes this fat out of the body before the body absorbs it. In this way, Chitosan helps to lower levels of bad LDL cholesterol and at the same time increase the levels of good HDL cholesterol. Chitosan has also exhibited anti-tumor action with its inhibitory action on tumor cells.. Chitosan is sold in a tablet form at many health stores and online and is advertised as a fat attractor or fat blocker. Chitosan can be purchased either as Chitosan supplements or as an ingredient in herbal diet pills. Chitosan is commonly used in diet pills because it has the ability to absorb six to eight times of its total weight in liquids. For this reason, Chitosan expands in the stomach and helps to suppress appetite as well ...
Physicochemical features and transfection properties of chitosan/poloxamer 188/poly(D,L-lactide-co-glycolide) nanoplexes Donato Cosco,1,5,* Cinzia Federico,1,2,* Jessica Maiuolo,1 Stefania Bulotta,1 Roberto Molinaro,1,3 Donatella Paolino,1,5 Pierfrancesco Tassone,2,4 Massimo Fresta1Department of Health Sciences, 2Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy; 3Department of NanoMedicine, The Methodist Research Institute, Houston, TX, USA; 4Medical Oncology, Tommaso Campanella Cancer Center, Viale S Venuta, Germaneto, 5Interregional Research Center for Food Safety and Health, University of Catanzaro “Magna Græcia”, Catanzaro, Italy*These authors contributed equally to this paperAbstract: The aim of this study was the evaluation of the effects of two emulsifiers on the physicochemical and technological properties of low molecular weight chitosan/poly (D,L-lactide-co-glycolide) (PLGA) nanoplexes and their transfection
In cancer theranostics, the main strategy of nanoparticle-based targeted delivery system has been understood by enhanced permeability and retention (EPR) effect of macromolecules. Studies on diverse nanoparticles provide a better understanding of different EPR effects depending on their structure, physicochemical properties, and chemical modifications. Recently the tumor microenvironment has been considered as another important factor for determining tumor-targeted delivery of nanoparticles, but the correlation between EPR effects and tumor microenvironment has not yet been fully elucidated. Herein, ectopic subcutaneous tumor models presenting different tumor microenvironments were established by inoculation of SCC7, U87, HT29, PC3, and A549 cancer cell lines into athymic nude mice, respectively. In the five different types of tumor-bearing mice, tumor-targeted delivery of self-assembled glycol chitosan nanoparticles (CNPs) were comparatively evaluated to identify the correlation between the ...
Preparation, characterization and evaluation of antibacterial activity of catechins and catechins-Zn complex loaded β-chitosan nanoparticles of different particle sizes.
Separation of phytosterol using chitosan from shell of shrimp (Penaeus monodon) has been investigated. The separation ability of phytosterol by chitosan is correlated with the binding ability of chitosan to phytosterol. Binding ability of chitosan with phytosterol is expressed in Binding Factor (BF). The first step in qualification of the binding property is the establishment of a standard calibration curve from interaction between chitosan with standard cholesterol and interaction between standard chitosan and standard p-sitosterol, commonly occurring in plant sterol. Analysis of the interaction involving chitosan with cholesterol is essential for comparison with phytosterol binding. The range of BF values obtained from the BF versus [P] graph for the interaction of chitosan with standard p-sitosterol range from 3.78 to 4.84 while the range of BF value is from 4.21 to 5.82 for the interaction involving chitosan from shrimp shell with p-sitosterol. The increase in BF values indicate a positive ...
Peptide (insulin) loaded nanoparticles (NPs) have been embedded into buccal chitosan films (Ch-films-NPs). These films were produced by solvent casting and involved incorporating in chitosan gel (1.25% w/v), NPs-Insulin suspensions at three different concentrations (1, 3, and 5 mg of NPs per film) using glycerol as plasticiser. Film swelling and mucoadhesion were investigated using 0.01 M PBS at 37 °C and texture analyzer, respectively. Formulations containing 3 mg of NPs per film produced optimised films with excellent mucoadhesion and swelling properties. Dynamic laser scattering measurements showed that the erosion of the chitosan backbone controlled the release of NPs from the films, preceding in vitro drug (insulin) release from Ch-films-NPs after 6 h. Modulated release was observed with 70% of encapsulated insulin released after 360 h. The use of chitosan films yielded a 1.8-fold enhancement of ex vivo insulin permeation via EpiOral™ buccal tissue construct relative to the pure drug. ...
Effects of chitosan and water-soluble chitosan micro- and nanoparticles in obese rats fed a high-fat diet Hong-liang Zhang,1,2 Xiao-bin Zhong,1 Yi Tao,3 Si-hui Wu,4 Zheng-quan Su21Department of Pharmacy, First Affiliated Hospital of Guangxi Medical University, Nanning, 2Key Research Center of Liver Regulation for Hyperlipemia SATCM/Level 3 Laboratory of Lipid Metabolism, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, 3HEC Pharm Group, Dongguan, 4Department of Pharmacy, Guangdong Food and Drug Vocational Technical School, Guangzhou, ChinaPurpose: This study determined the effects of chitosan (CTS) and water-soluble chitosan (WSC) microparticles (MPs) and nanoparticles (NPs) in rats with high-fat diet-induced obesity.Methods: The rats were randomly separated into eight groups: a normal diet group (the blank control), a high-fat emulsion group (the negative control), CTS and WSC control groups, CTS-MP and WSC-MP groups, and CTS-NP and WSC-NP groups. All groups
TY - JOUR. T1 - Antibacterial effects of chitosan/cationic peptide nanoparticles. AU - Tamara, Frans Ricardo. AU - Lin, Chi. AU - Mi, Fwu Long. AU - Ho, Yi Cheng. N1 - Funding Information: Acknowledgments: The authors gratefully acknowledge the financial support provided by the by the Ministry of Science and Technology, Taiwan, ROC (MOST 104-2320-B-415-004), Taiwan, Republic of China.. PY - 2018/2/5. Y1 - 2018/2/5. N2 - This study attempted to develop chitosan-based nanoparticles with increased stability and antibacterial activity. The chitosan/protamine hybrid nanoparticles were formed based on an ionic gelation method by mixing chitosan with protamine and subsequently cross-linking the mixtures with sodium tripolyphosphate (TPP). The effects of protamine on the chemical structures, physical properties, and antibacterial activities of the hybrid nanoparticles were investigated. The antibacterial experiments demonstrated that the addition of protamine (125 µg/mL) in the hybrid nanoparticles ...
The aim of this study was to evaluate the antibacterial efficacy of copper added chitosan nanoparticles (CU-CNPs) as an irrigation solution with different irrigants in terms of eliminating Enterococcus Faecalis (E. faecalis) from the root canals. Fifty mandibular premolar teeth were prepared and infected with E. faecalis for 21 days. After the incubation period, samples were randomly divided into a control group irrigated with distilled water and 4 experimental groups (n = 10) irrigated with as follows, %6 NaOCl, %6 NaOCl + %9 editronate (HEBP), Chitosan nanoparticles (CNPs), and CU-CNPs. To calculate the proportion of dead E. faecalis cell volume, stained using LIVE/DEAD BacLight Bacterial Viability Kit and were scanned using confocal laser scanning microscope (CLSM). All the irrigation solutions significantly (P < .05) killed the bacteria in the canal, except for the control group. CU-CNPs solution killed the highest (P < .05) number of bacteria compared with the other experimental groups. No ...
NutraGenesis, LLC, Brattleboro, VT, has launched Orisett, a naturally derived, patent-pending nutraceutical designed to define the benchmark for the glucose management category. Orisett contains low molecular weight chitosan oligosaccharide bioactive
TY - JOUR. T1 - Functional hybrid fibers of cellulose/microcrystalline chitosan. I. Manufacture of viscose/microcrystalline chitosan fibers. AU - Nousiainen, Pertti. AU - Vehviläinen, Marianna. AU - Struszczyk, Henryk. AU - Mäkinen, Elina. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Blends of microcrystalline chitosan (MCCh) with cellulose xhanthate alkaline solutions were prepared to investigate the effects of aqueous MCCh gel concentration and additives on the spinnability of hybrid cellulose/chitosan fibers and their properties. The properties of the spinning solution were mainly dependent on the concentration of MCCh in the aqueous gel-like dispersion and the amount mixed into the cellulose xhanthate solution. Sodium alginate chemically close to cellulose and chitosan was used as an additive to improve the miscibility of chitosan due to the ionic bonds formed with chitosan 2-amino groups. Using an optimized ratio of 2:1 of MCCh to the sodium alginate, a maximum of 6% of MCCh calculated from ...
Enhanced oral bioavailability of poorly aqueous soluble drugs encapsulated in a number of lipid-based formulations, including emulsions, micellar systems, self-emulsifying drug delivery systems, liposomes and solid lipid nanoparticles (SLN) via lymphatic delivery has been documented (1). In the present work, SLN were designed for the oral delivery of heparin in order to take advantage from the lymphatic intestinal transport pathway. In order to improve the incorporation of a high hydrophilic compound in a lipid matrix, heparin was insolubilized by the coupling with chitosan. In this aim we have developed chitosan/heparin Polyelectrolyte complexes (PEC). Such as systems are able to complex stably heparin (up to pH , 6.8) (2) and after pelletization by centrifugation were embedded in SLN obtaining a hybrid system lipid/chitosan nanoparticles (PEC-SLN). Since no in-vitro lymphoid tissue is currently available, CaCo-2 cell monolayer could be considered an alternative in vitro model to be used as a ...
Abstract Chitosan-based porous scaffolds are of great interest in biomedical applications especially in tissue engineering because of their excellent biocompatibility in vivo, good texture, surface contact, controllable degradation rate and tailorable mechanical properties. These days biomaterials scaffolds have contributed as an alternative choice of therapy mainly due to the increase failure rates in autografts and allografts techniques. Terbinafine HCl is allylamines group of drugs which is used topically to treat dermatophyte group of fungi like ringworm. Chitosan possesses both anti-bacterial and antifungal property which synergises with Terbinafine HCl (TBH) for both prophylactic and therapeutic actions in treating fungal wound infection (FWI). The haemostatic property of chitosan allows sorption of plasma, erythrocyte coagulation and platelets activation. These properties contribute additional role in repairing debilitated tissue. The prolong drug release property of fabricated scaffold ...
As 95% of all prescriptions are for orally administered drugs, the issue of oral absorption is central to the development of pharmaceuticals. Oral absorption is limited by a high molecular weight (,500 Da), a high log P value (,2.0) and low gastrointestinal permeability. We have designed a triple action nanomedicine from a chitosan amphiphile: quaternary ammonium palmitoyl glycol chitosan (GCPQ), which significantly enhances the oral absorption of hydrophobic drugs (e.g., griseofulvin and cyclosporin A) and, to a lesser extent, the absorption of hydrophilic drugs (e.g., ranitidine). The griseofulvin and cyclosporin A C(max) was increased 6- and 5-fold respectively with this new nanomedicine. Hydrophobic drug absorption is facilitated by the nanomedicine: (a) increasing the dissolution rate of hydrophobic molecules, (b) adhering to and penetrating the mucus layer and thus enabling intimate contact between the drug and the gastrointestinal epithelium absorptive cells, and (c) enhancing the ...
Chitosan Oligosaccharide Appearance: Yellow and light brown Odor: Sightly smell as acetic acid Molecular weight: less than 1500,less than 3000,less than5000 Degree of polymerization (DP): 2-10 Particle size: ≥100 mesh Moisture: ≤10% Residue on ignition :
The pH dependent adsorption behavior of chitosan onto a cellulose model surface was studied by quartz crystal microbalance with dissipation (QCM-D). The molecular level interactions between adsorbed chitosan layers were studied by atom force microscopy (AFM) colloidal probe force measurements in the liquid phase. Adsorption of chitosan increased with pH below the solubility limit of the polymer. The adsorption behavior could not be accounted for solely on the basis of electrostatic interactions; thus a specific interaction between the polymers existed. Swelling and viscoelastic properties of the adsorbed chitosan layer were strongly influenced by pH. At high pH, the layer deswelled and became more elastic due to insolubility of the chitosan. The colloidal probe force measurements showed a rise of electrosteric repulsion after adsorption of chitosan at pH 5. Above the solubility limit of the chitosan, at pH 7, the pull-off force and its range clearly increased compared to lower pH values, ...
This study aimed to investigate the inhibitive effects of chitosan oligosaccharides (COS) on tumor necrosis factor (TNF)-alpha-induced over-expression of vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs). We found that COS effectively inhibited TNF-alpha-induced expression of VCAM-1 and ICAM-1 at the level of transcription and translation. Signal transduction studies suggested that COS blocked TNF-alpha-induced activation of NF-kappa B, degradation of I kappa B alpha, and phosphorylation of p38 MAPK and ERK1/2. A further investigation showed that the NF-kappa B activation can be partly suppressed by p38 MAPK inhibitor (58203580) and ERK1/2 inhibitor (PD98059), which also ameliorated the mRNA expression of VCAM-1 and ICAM-1 in TNF-alpha-induced HUVECs. Additionally, COS decreased U937 monocyte adhesion to HUVECs induced by TNF-alpha. Our findings suggest that COS inhibit VCAM-1 and ICAM-1 production in activated ...
Sigma-Aldrich offers abstracts and full-text articles by [Koen van der Maaden, Emine Sekerdag, Pim Schipper, Gideon Kersten, Wim Jiskoot, Joke Bouwstra].
This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films ...
Chitosan sponges were developed for adjunctive local antibiotic delivery to reduce bacteria in wounds. There is a need to increase sponge degradation for rapid clearance from the wound site during initial wound care. This work examined the effect of using 0.25 M sodium acetate buffers, at pH 4.6 or 5.6, to fabricate sponges with an amorphous chitosan polymer structure. Sponges were evaluated for their crystallinity, thermal, spectroscopic, and morphological properties, in addition to in vitro degradation, and cytocompatibility analysis using normal human dermal fibroblasts. In vivo degradation and biocompatibility were also examined after 4 and 10 days in rat intramuscular tissues. Both buffered chitosan sponge variations exhibited decreases in crystallinity and thermal decomposition temperatures, and increases in surface roughness, which resulted in over 40% increases in degradation over 10 days in vitro compared to the neutral sponges. There were no significant differences between sponges ...
Figure 11: DSC thermograms of (a) DRZ loaded OCM-CSNPs, (b) Blank OCM-CSNPs, and (c) DRZ powder. Thermogram showed a shift in endotherm when DRZ was loaded showing a strong interaction of DRZ with OCM-CS. Abbreviations: OCM-CSNPs, 6-O-carboxymethyl chitosan nanoparticles; DRZ, dorzolamide hydrochloride; DSC, differential scanning calorimetry ...
The simultaneous and sequential dual elicitation effect on plumbagin production in Plumbago indica L. root cultures, revealed that combination of chitosan (150 mg L−1) with ʟ-alanine (5 mM) or methyl-β-cyclodextrin (MCD; 2 mM) significantly increased plumbagin production, but in the different treatment manners. The simultaneous treatment using chitosan + ʟ-alanine on a 14-day-old culture enhanced plumbagin production to 14.62 mg g−1 DW, while the sequential additions of MCD to a 12-day-old culture followed by chitosan after 48 h enhanced production of plumbagin to 14.33 mg g−1 DW. The plumbagin productivity from both treatments were up to 1.3- and 8-fold higher than the chitosan treated (10.93 mg g−1 DW) and untreated root cultures (1.76 mg g−1 DW). Moreover, the present studies provided new information on the effect of simultaneous and sequential elicitation on plumbagin-producing P. indica root cultures using chitosan in combinations with MCD or ʟ-alanine.
TY - JOUR. T1 - In-situ analysis of polyelectrolyte complexes by flow cytometry. AU - Strand, Anders. AU - Vähäsalo, L. AU - Ketola, A. AU - Salminen, K. AU - Retulainen, E. AU - Sundberg, Anna. N1 - 3pk. PY - 2018. Y1 - 2018. KW - Polyelectrolyte complex. KW - CMC. KW - Structural density. KW - Light scattering. KW - cationic starch. KW - Polyelectrolyte complex. KW - CMC. KW - Structural density. KW - Light scattering. KW - cationic starch. KW - Polyelectrolyte complex. KW - CMC. KW - Structural density. KW - Light scattering. KW - cationic starch. U2 - 10.1007/s10570-018-1832-1. DO - 10.1007/s10570-018-1832-1. M3 - Artikel. VL - 25. SP - 3781. EP - 3795. JO - Cellulose. JF - Cellulose. SN - 0969-0239. IS - 7. ER - ...
The main objective of this research was to investigate the effect of chitosan content and chemical modification with acetic acid on mechanical and thermal properties of PP/Chitosan. It was found that the tensile strength, elongation at break and crystallinity of untreated PP/Chitosan composites decreased with increasing filler content; however, Youngs modulus and thermal stability increased. The treated chitosan with acetic acid have improved the tensile strength and Youngs modulus of PP/Chitosan composites. The thermal analysis results show that chemical modified chitosan had increase thermal stability and crystallinity of treated PP/Chitosan composites. The scanning electron microscopy (SEM) study of the tensile fracture surface of treated PP/Chitosan composites indicated that the presence of acetic acid increased the interfacial interaction between chitosan and polypropylene ...
High-Performance Ceramics IV: Physicochemical and Mechanical Properties of Composite of Chitosan Microspheres/Calcium Phosphate Cement
Low-density polyethylene (LDPE) belongs to commodity polymer materials applied in biomedical applications due to its favorable mechanical and chemical properties. The main disadvantage of LDPE in biomedical applications is low resistance to bacterial infections. An antibacterial modification of LDPE appears to be a solution to this problem. In this paper, the chitosan and chitosan/pectin multilayer was immobilized via polyacrylic acid (PAA) brushes grafted on the LDPE surface. The grafting was initiated by a low-temperature plasma treatment of the LDPE surface. Surface and adhesive properties of the samples prepared were investigated by surface analysis techniques. An antibacterial effect was confirmed by inhibition zone measurements of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The chitosan treatment of LDPE led to the highest and most clear inhibition zones (35 mm ; 2 for E. coli and 275 mm ; 2 for S. aureus ...
Nitric oxide (NO) is involved in physiological processes, including vasodilatation, wound healing and antibacterial activities. As NO is a free radical, designing drugs to generate therapeutic amounts of NO in controlled spatial and time manners is still a challenge. In this study, the NO donor S-nitrosoglutathione (GSNO) was incorporated into the thermoresponsive Pluronic F-127 (PL) - chitosan (CS) hydrogel, with an easy and economically feasible methodology. CS is a polysaccharide with known antimicrobial properties. Scanning electron microscopy, rheology and differential scanning calorimetry techniques were used for hydrogel characterization. The results demonstrated that the hydrogel has a smooth surface, thermoresponsive behavior and good mechanical stability. The kinetics of NO release and GSNO diffusion from GSNO-containing PL/CS hydrogel demonstrated a sustained NO/GSNO release, in concentrations suitable for biomedical applications. The GSNO-PL/CS hydrogel demonstrated a concentration-dependent
It will be a requirement for the formation of a stoma or ileostomy, Preparation of AB loaded chitosan nanoparticles it is likely that you will to take them for the rest of your life. Clinical measurements were made using williams periodontal probe with graduation to a precision of 1 mm. didanosine kansas city buy Video of epidural steroid injection As bilirubin starts to accumulate in the blood stream it can give someone a yellowish color to their skin and eyes. order didanosine ...
PURPOSE: Functional starch vermicelli(tangmyeon) and a preparation method thereof are provided, which starch vermicelli(tangmyeon) has nutrition and function of green tea and chitosan, and maintains its native texture taste. CONSTITUTION: The method for preparing the functional starch vermicelli(tangmyeon) comprises the steps of: mixing 95 to 99 wt.% of potato or sweet potato starch with 1 to 5 wt.% of pulverized green tea leaves with 100 to 200 meshes to prepare mixed starch for starch vermicelli(tangmyeon); mixing 11 to 19 wt.% of potato or sweet potato starch, 2 to 10 wt.% of chitosan solution wherein chitosan has the molecular weight of 10,000 to 50,000 dalton and deacetylation degree of 90 to 95%, and 69 to 86 wt.% of water to prepare gruel; mixing 55 to 65 wt.% of the mixed starch for starch vermicelli(tangmyeon) with 35 to 45 wt.% of gruel and kneading the mixture; removing the air from the dough for starch vermicelli(tangmyeon); and preparing starch vermicelli(tangmyeon) using the dough.
Purpose : To evaluate the in vitro and in vivo drug release of a biodegradable injectable sheet made of cross-linked chitosan and gelatin mixture. Methods : Gelatin and chitosan were solved in water and 1% acetic acid at concentrations of 5 wt% and 2.5 wt%, respectively. Then, 5 wt% gelatin and 2.5 wt% chitosan was mixed at the ratio of 3 : 2 (vol). The drug was mixed with the 3 wt% gelatin/1 wt% chitosan mixture. Fluorescein isothiocyanate (FITC), FITC-labeled dextran 150 kDa (FD150), and FITC-labeled albumin (FITC-ALB) were used as drugs. Immedeately after adding water soluble carbodiimide in the gelatin/chitosan/drug mixture at final concentration of 10 mg/mL, 3 μL of the mixture was cast in the polydimethylsilane (PDMS) mold (internal diameter; 2.76 mm, depth; 0.5 mm). Then, the cross-linked gels were dried for 1 hour at room temperutere to make flexible sheets. The sheets were incubated in phosphate buffered saline (PBS) at 37 degrees C. The drug concentration in PBS were measured ...
Global Chitosan Gel Market Research Report 2021|br /| with 105 pages available at USD 2900 for single User PDF at ReportsWeb research database.
The growth of polysaccharide multilayers consisting of positively charged chitosan (CH) and negatively charged heparin (HEP) was monitored in situ by employing a quartz crystal microbalance (QCM-D) and dual-polarization interferometry (DPI). The main focus was on how the physicochemical properties of the solution affect the growth and structure of the resulting multilayer film These results showed that when increasing the ionic strength of the polysaccharide solutions at a fixed pH, both the dry (optical) (DPI) mass and wet (QCM) mass of the adsorbed multilayer film increased. The same effect was found when increasing the pH while keeping the ionic strength constant. Furthermore, the growth of multilayers showed an exponential-like behavior independent of the solution conditions that were used in this study. It was also established that chitosan was the predominant species present in the chitosan heparin multilayer film. We discuss the viscoelastic properties of the adsorbed layers and their ...
MarketResearchReports.Biz presents this most up-to-date research on Chitosan Market for Water Treatment, Biomedicine & Pharmaceutics, Industrial, Food & Beverages, Cosmetics, Agrochemical and Other Applications. Description. This report covers the forecast and analysis of the chitosan market on global and regional levels. The study provides historic data of 2013 along with the forecast from 2014 to 2020, based on both volume (Tons) and revenue (USD million). The study includes drivers and restraints of the chitosan market, along with their impact on demand and production during the forecast period. Additionally, the report comprises the study of opportunities available in the market on the global and regional level.. We have included a detailed value chain analysis in order to provide a comprehensive view of this market. An analysis of Porters five forces model has also been included to help understand the competitive landscape in the market. The study encompasses market attractiveness ...
In accordance with this invention, an aqueous solution of drug or drugs and alginate is prepared in DW/NS/PBS with an alginate: drug ratio of 1:6-1:8 w/w and a final alginate concentration of 0.05-0.07% w/v. Methanol may be added (if one of the drug is hydrophobic) in a ratio of 0.2:1-10 v/v. The mixture can comprise an excess amount of drug solution or sodium alginate solution, but which would only constitute a waste. To the mixture is added an aqueous solution of calcium chloride (drug-alginate solution: calcium chloride solution-18:1-22:1 v/v) with a molarity of calcium chloride maintained between 15-20mM. To the mixture is further added an aqueous solution of chitosan (drug-alginate solution: chitosan solution=8:1-12:1 v/v) with an alginatexhitosan ratio maintained preferably, but not limited to a ratio between 4:1-7:1 w/w. The nanoparticles formed are left as such for l-18h and subsequently collected by centrifugation at 19,000-37,000 rpm, at 4°C-30°C for 30 min-45 min ...
Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (S-w) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low S-w. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that S-w of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser ...
Iurea Delia, Popa Marcel, Chailan Jean-François, Tamba Bogdan, Ionut Tudorancea, Peptu Catalina Journal of Bioactive and Compatible Polymers (2013) 28(4), 368-384 ...
In this study, we compared the effects of low molecular weight(LMW)chitosan(MW:25, 000-50, 000), high molecular weight(HMW)chitosan(MW:500, 000-1000, 000)and chitin on ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats.Oral administration of LMW chitosan(250, 500 and 1000mg/kg)dose-dependently prevented ethanol-induced gastric mucosal injury.Repeated oral administration of LMW chitosan(100, 200 and 400mg/kg twice daily)also dose-dependently accelerated the gastric ulcer healing.However, the effects of HMW chitosan and chitin on the gastric mucosal injury formation and the gastric ulcer healing were less potent than those of LMW chitosan.LMW chirosan(250 and 500mg/kg, orally)was ineffective in inhibiting gastric acid secretion in pylorus-ligated rats, although it had a weak acid-neutralizing action.LMW-chitosan(250, 500 and 1000mg/kg orally)dose-dependently prevented the decrease in gastric mucus content induced by ethanol.These results ...
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Natural biomaterials such as collagen show promise in tissue engineering applications due to their inherent bioactivity. The main limitation of collagen is its low mechanical strength and somewhat unpredictable and rapid degradation rate; however, combining collagen with another material, such as chitosan, can reinforce the scaffold mechanically and may improve the rate of degradation. Additionally, the high cost and the risk of prion transmission associated with mammal-derived collagen has prompted research into alternative sources such as marine-origin collagen. In this context, the overall goal of this study was to determine if the incorporation of chitosan into collagen scaffolds could improve the mechanical and biological properties of the scaffold. In addition the study assessed if collagen, derived from salmon skin (marine), can provide an alternative to collagen derived from bovine tendon (mammal) for tissue engineering applications. Scaffold architecture and mechanical properties were ...
Some cationic composite hydrogels based on chitosan (CS) and poly (N-2-aminoethyl acrylamide) (PAEA) covalently cross-linked with glutaraldehyde (GA) were tested as novel sorbents for two dis-azo dyes: Congo Red and Direct Blue 1. Three CS-based composite hydrogels having different molar ratios between the primary amine groups and the cross-linking agent (GA/NH2 = 5.3 and 12.5), the same total concentration of polycations (CPC = 2 wt%) and two molar ratios between polycations (PAEA:CS = 0.25 and 1.2) were used for this study. Pseudo-first order model, pseudo-second order model and the intraparticle diffusion model were used to analyze the experimental data in order to establish the mechanism of adsorption. The adsorption kinetics has been well described by the pseudo-second order model. The effect of temperature on the adsorption of both dyes has been also investigated.
Complex coacervation of two oppositely charged polysaccharides, namely a lactose-modified chitosan (CTL) and hyaluronan (HA), was investigated in this study. Coacervates of the two polysaccharides were prepared by drop-by-drop injection of HA into CTL. Transmittance and dynamic light scattering (DLS) measurements in combination with TEM analyses demonstrated the formation of spheroidal colloids in the nano-/microsize range showing good homogeneity. Strikingly, the presence of 150 mM supporting NaCl did not hamper the colloid formation. Stability studies on selected formulations demonstrated that HA/CTL coacervates were stable up to 3 weeks at 37 °C and behaved as pH-responsive colloids since transition from entangled to disentangled chains was attained for a proper pH range. The possibility of freeze-drying the coacervates for storage purposes and the ability of encapsulating selected payloads were investigated as well, for two values of the fraction of the lactitol side-chain substitution ...
The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d = 5.2 +/- 1.1 nm) was presented in the case of poorly water soluble Ca2+ channel blocker nimodipine (NIMO) drug molecules. The adequate pH-sensitivity, i.e. the suitable drug carrier properties of the initial hydrophilic Chit were achieved by reductive amination of Chit with hexanal (C6(-)) and dodecanal (C12(-)) aldehydes. The successful modifications of the macromolecule were evidenced via FTIR measurements: the band appearing at 1412 cm(-1) (C-N stretching in aliphatic amines) in the cases of the hydrophobically modified Chit samples shows that the C-N bond successfully formed between the Chit and the aldehydes. Hydrophobization of the polymer unambiguously led to lower water contents with lower intermolecular interactions in the prepared hydrogel matrix: the initial hydrophilic Chit has the highest water content (78.6 wt%) and the increasing hydrophobicity of the polymer ...
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Porous scaffolds made of chitosan, polyvinyl alcohol and hydroxyapatite were prepared via freeze-drying method. In this matter, three different volume ratios of polymer solutions (1:1, 1:3, 3:1) and constant hydroxyapatite mass ratio were blended. Glutaraldehyde and glycerol were added as a polymer-chain crosslinker and plasticizer, respectively. The obtained scaffolds were used to test bone proliferation and potential for bone regeneration and they were characterized through FTIR, mechanical tests, cell cultures and swelling tests. Every quantitative measurement was statistically tested using two-way analysis of variance (ANOVA) with , 0.05. Partial results from cell culture have been obtained, showing faster cell differentiation in the scaffolds combined with glutaraldehyde and glycerol. Crosslinked scaffolds showed better swelling conditions than those that were not subject to this chemical reaction. Besides, samples with higher chitosan ratio exhibited better swelling behavior. Experiments ...
Chitosan-containing acrylic fibers having a total chitosan content of 0.05 to 2 % by weight and an extractable chitosan content of not less than 0.03 % by weight to less than the total chitosan content. The antimicrobial activity of the fibers can persist for a long period of time and is not deteriorated even when subjected to posttreatments, such as dyeing and bleaching of fibers, and treatments in usual service environments of fiber products, such as washing and ironing.
The regeneration of new bone or cartilage to restore the function of traumatized, damaged, or lost bone or cartilage is a major clinical and socioeconomic burden. In recent years, a new cutting-edge procedure, bone- and cartilage-tissue engineering, has emerged as a new strategy for healing musculoskeletal conditions. In this strategy, progenitors or mature cells are combined with biocompatible scaffolds to initiate partial or full bone and/or cartilage regeneration.Scaffolding materials in tissue engineering should be bioactive and biodegradable. The synthetic polymers, such as PLA and PGA, are biodegradable, but not bioactive. Furthermore, their bulky degradation style and induction of foreign body reaction limit their clinical applications. Chitosan and alginate, two natural polymers, have proven to be biodegradable and bioactive for bone and cartilage regeneration. In this study, high-concentration (4.8% w/v) chitosan-alginate hybrid scaffolds were successfully synthesized through a ...
Mesangioproliferative glomerulonephritis is a disease that has a high incidence in humans. In this disease, the proliferation of glomerular mesangial cells and the production of extracellular matrix are important. In recent years, the RNAi technology has been widely used in the treatment of various diseases due to its capability to inhibit the gene expression with high specificity and targeting. The objective of this study was to decrease mesangial cell proliferation by knocking down PDGF-B and its receptor, PDGFR-beta. To be able to use small interfering RNAs (siRNAs) in the treatment of this disease successfully, it is necessary to develop appropriate delivery systems. Chitosan, which is a biopolymer, is used as a siRNA delivery system in kidney drug targeting. In order to deliver siRNA molecules targeted at PDGF-B and PDGFR-beta, chitosan/siRNA nanoplexes were prepared. The in vitro characterization, transfection studies, and knockdown efficiencies were studied in immortalized and primary rat ...
Journal of Anthropology and Archaeology is a peer-reviewed international journal, which publishes original papers promoting theoretical, methodological and empirical developments in the discipline of socio-cultural anthropology.
Title:Polymeric Micelles of Modified Chitosan Block Copolymer as Nanocarrier for Delivery of Paclitaxel. VOLUME: 9 ISSUE: 1. Author(s):V. Lather, V. Saini and D. Pandita*. Affiliation:Department of Pharmaceutical Chemistry, JCDM College of Pharmacy, Sirsa-125055, Haryana, Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa-125055, Haryana, Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa-125055, Haryana. Keywords:Polymeric micelles, amphiphilic, self assembly, chitosan, paclitaxel, copolymer.. Abstract:Background: Polymeric micelles are being used as successful nanocarriers for the delivery of diverse drug molecules due to properties like solubilization, selective targeting, P-glycoprotein inhibition, altered drug internalization route and subcellular localization etc. Objective: The present investigation was planned to prepare and characterize novel polymeric micelles derived from self assembly of amphiphilic chitosan-bile salt derivative (CS-mPEG-DA) as nanocarrier and ...
In this research, chitosan was used for the removal of Cr (VI) ions from aqueous solution. The effect of parameters like solution pH, initial Cr (VI) concentration, agitation time, amount of adsorbent and agitation speed on the adsorption process was studied. The experimental equilibrium data were analyzed by using various models such as Langmuir and Freundlich. Freundlich isotherm model fitted well with data. In addition, the experimental data was fitted to kinetic models including the pseudo-first-order and pseudo-second-order and based on calculated respective parameters such as rate constants, equilibrium adsorption capacities and correlation coefficients. The removal process follows the pseudo-second-order kinetic model. The results suggest that chitosan could be employed as a low-cost material for the removal of Cr(VI) ions from aqueous solutions.  Â
Calories in Stacker 3 With Chitosan Thermogenic Weight Loss Pill. Find nutrition facts for Stacker 3 With Chitosan Thermogenic Weight Loss Pill and over 2,000,000 other foods in MyFitnessPal.coms food database.
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The composition, developed and patented by the UA Research Group in Plant Pathology, is based on the combined use of chitosan, or chitosan oligosaccharides (COS), antifungal agents and additives that synergistically affect the growth of a variety of pathogenic fungi ...
In this thesis poloxamer and poloxamer-chitosan nanosystems loaded with melatonin or without melatonin were prepared using direct dissolution method. The main technological characteristics of prepared nanosystems (size, size distribution and surface charge) were deterimined. The mean particle size of poloxamer and poloxamer-chitosan nanosystems without melatonin are between 23.3 and 24.5 nm, the polydispersity index values are in the range from 0.315 to 0.340. The zeta potential of poloxamer micelles without addition of chitosan in acetate buffer pH 6.0 is around 0 mV, due to the nonionic nature of poloxamer. The zeta potential of particles in poloxamer-chitosan nanonsystems is around 1.5 mV because chitosan at this pH is only partially protonated, and the part of chitosan charge shadowed by nonionic poloxamer micelles. An average hydrodynamic diameter of melatonin loaded poloxamer and poloxamer-chitosan micelles are in the range from 20.0 to 20.7 nm; the polydispersity index is from 0.176 to ...
Concrete is significant for construction. A problem in application is the appearance of cracks that will damage its strength. An autogenous crack-healing mechanism based on bacteria receives increasing attention in recent years. The bacteria are able to form calcium carbonate (CaCO3) precipitations in suitable conditions to protect and reinforce the concrete. However, a large number of spores are crushed in aged specimens, resulting in a loss of viability. A new kind of hydrogel crosslinked by alginate, chitosan and calcium ions was introduced in this study. It was observed that the addition of chitosan improved the swelling properties of calcium alginate. Opposite pH response to calcium alginate was observed when the chitosan content in the solution reached 1.0%. With an addition of 1.0% chitosan in hydrogel beads, 10.28% increase of compressive strength and 13.79% increase of flexural strength to the control were observed. The results reveal self-healing properties of concretes. A healing ...
Photodynamic medicine is a novel approach for cancer therapy and diagonosis via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (Pp IX ) that can be utilized as a fluorescent probe for tumor detection, however, this biosynthetic pathway also can be occurred in normal flora, including E. coli, in the colon and rectum that influence the efficacy of tumor detection. In this study, 5-ALA was encapsulated in chitosan nanoparticles to prevent uptake of E. coli. This result implied that chitosan can exclude the influence of normal flora inside the gut and serves as an ideal vector of colon-specific drug delivery system. According to this concept, we designed a novel photodynamic detection system to enhance the accuracy of endoscopic diagnosis for early colorectal cancer.
Chitooligosaccharides (COS) with degrees of polymerization (DP) 6 to 8 are degraded from chitosan, which possess excellent bioactivities. However, technologies that could purify them from hydrolysis mixtures in the narrow DP range (984 to 1,306 Da) are absent. The objective of this research is to purify DP 6 to 8 COS by nanofiltration on the basis of appropriate adjustments of the feed condition. Syrup containing DP 6 to 8 COS at different concentrations (19.0 to 46.7 g/L) was prepared. A commercial membrane (QY-5-NF-1812) negatively charged was applied. Experiments were carried out in full recycle mode, so that the observed COS retentions were investigated at various transmembrane pressures (6.0 to 20.0 bar), temperatures (10°C to 50°C), and pHs (5.0 to 9.0). Then, the feasibility of separation of DP 6 to 8 COS was further studied by concentration ratio under optimum conditions. The results indicate that the purification of DP 6 to 8 COS by nanofiltration NF is feasible. It was found that the
TY - JOUR. T1 - Assembly of polyelectrolyte-containing block copolymers in aqueous media. AU - Cohen Stuart, Martien A.. AU - Hofs, Bas. AU - Voets, Ilja K.. AU - de Keizer, Arie. PY - 2005/8/1. Y1 - 2005/8/1. N2 - In this review we present an overview of the developments of (self-)assembly of linear block copolymers containing one or more polyelectrolyte blocks in aqueous solution. Different micellar structures and phase behaviour are described. The role of inter- and intramolecular complex coacervation is emphasised. Recent developments in applications of assembly of polyelectrolyte-containing copolymers are presented.. AB - In this review we present an overview of the developments of (self-)assembly of linear block copolymers containing one or more polyelectrolyte blocks in aqueous solution. Different micellar structures and phase behaviour are described. The role of inter- and intramolecular complex coacervation is emphasised. Recent developments in applications of assembly of ...
New approaches to deal with drug-resistant pathogenic bacteria are urgent. We studied the antibacterial effect of chitosans against an |i|Escherichia coli|/i| quorum sensing biosensor reporter strain and selected a non-toxic chitosan to evaluate its quorum sensing (QS) inhibition activity and its ef …
The use of materials, containing the biocompatible and bioresorbable biopolymer poly()-2-amino-2-deoxy--D-glucan, containing some N-acetyl-glucosamine units (chitosan, CHI) and/or its derivatives, to fabricate devices for the regeneration of bone, cartilage and nerve tissue, was reviewed. The CHI-containing devices, to be used for bone and cartilage regeneration and healing, were tested mainly for in vitro cell adhesion and proliferation and for insertion into animals; only the use of CHI in dental surgery has reached the clinical application. Regarding the nerve tissue, only a surgical repair of a 35 mm-long nerve defect in the median nerve of the right arm at elbow level with an artificial nerve graft, comprising an outer microporous conduit of CHI and internal oriented filaments of poly(glycolic acid), was reported. As a consequence, although many positive results have been obtained, much work must still be made, especially for the passage from the experimentation of the CHI-based devices, in ...
Green Pesticide Formulation Development is the focus of current research . Mainly related to the ultra-efficient , low toxicity ( or non-toxic ) , low-residue , environmental pollution , chemical pe
Moerschbacher, Bruno (26 March 2018). "13th International Conference on Chitin and Chitosan" (PDF). Chitosan. Retrieved 26 ...
"Biofabrication with Chitosan". Biomacromolecules. 6 (6): 2881-2894. doi:10.1021/bm050410l. ISSN 1525-7797. PMID 16283704. v t e ...
These properties allow for various biomedical applications of chitosan. Chitosan as drug delivery: Chitosan is used mainly with ... Chitosan as an anti-microbial agent: Chitosan is used to stop the growth of microorganisms. It performs antimicrobial functions ... Chitosan is another popular biopolymer in biomedical research.[according to whom?] Chitosan is derived from chitin, the main ... Chitosan composite for tissue engineering: Blended powder of chitosan along with alginate are used together to form functional ...
The degree of this process determines the physical and chemical properties of the chitosan. Chitosan has antibacterial ... Chitosan is derived from chitin in a process known as alkaline deacetylation (substituting out certain amino acid groups). ... Chitosan's resemblance to glycosaminoglycans and internal interactions between glycoproteins and proteoglycans make it highly ... One potential disadvantage of chitosan is that it degrades in the presence of lysozymes (naturally occurring enzymes). But, ...
"Chitosan: Derivatives, Composites and Applications , Wiley". Wiley.com. "Biocomposites". Ahmed, Shakeel, ed. (September 16, ... Materials Applications of Advanced Green Materials Bionanocomposites in Tissue Engineering and Regenerative Medicine Chitosan ...
Wang, Chung-Hao; Chang, Chia-Wei; Peng, Ching-An (2010-12-18). "Gold nanorod stabilized by thiolated chitosan as photothermal ... Polymers, such as Polyethylene glycol (PEG), Polyallylamine hydrochloride (PAH) coating; dietary fibers, such as chitosan; or ...
"Chitosan and thiolated chitosan: Novel therapeutic approach for preventing corneal haze after chemical injuries". Carbohydr. ... "Chitosan and thiolated chitosan: Novel therapeutic approach for preventing corneal haze after chemical injuries". Carbohydr. ... Bae, IH; Jeong, BC; Kook, MS; Kim, SH; Koh, JT (2013). "Evaluation of a thiolated chitosan scaffold for local delivery of BMP-2 ... In case of thiolated chitosan, for instance, a more than 10,000-fold increase in viscosity within a few minutes was shown. ...
One difference between chitin and chitosan is that chitosan is soluble in acidic aqueous solutions. Chitosan is easier to ... Chitosan is a deacetylated derivative of chitin. When the acetylated composition of the copolymer is below 50% it is chitosan. ... Due to its ease of processing, chitosan is used in biomedical applications. Collagen is a structural protein, often referred to ... Chitosan is a semicrystalline "polymer of β-(1-4)-2-amino-2-deoxy-D-glucose". ...
pKa values of chitosans can be calculated from the dependency of electrophoretic mobility values on pH and charge density. Like ... "Chitosan-graft-polyethylenimine as a gene carrier". Journal of Controlled Release. Elsevier BV. 117 (2): 273-280. doi:10.1016/j ... "Electrophoretic Light Scattering Studies of Chitosans with Different Degrees ofN-acetylation". Biomacromolecules. American ... proteins, the size and zeta potential of chitosans can be determined through ELS. ELS has also been applied to nucleic acids ...
Chitosan hemostatic agents are salts formed when chitosan is combined with an organic acid (lactic acid, or Succinic acid). The ... Chitosan, a natural polymer that is biocompatible, non-allergenic, biodegradable, and non-toxic, was also looked at for its ... Chitosan may function as an inhibitor of bacterial and fungal development. In 2003, the United States Food and Drug ... Combat medics use Hemcon dressings, which is a dressing with Chitosan, to treat wounds because it stops the blood flow with its ...
Chitosan, a frequently used example, is cationic. Since DNA is negatively charged, DNA could be attached to chitosan as a way ... Cao, Ye; Tan, Yang Fei; Wong, Yee Shan; Liew, Melvin Wen Jie; Venkatraman, Subbu (2019-06-25). "Recent Advances in Chitosan- ... Examples include chitosan, hyaluronic acid, alginic acid and dextran. ...
Lauto, A., Mawad, D., Barton, M., Gupta, A., Piller, S. C., & Hook3, J. (2010). Photochemical tissue bonding with chitosan ... Lauto, A., Mawad, D., Barton, M., Piller, S. C., & Longo, L. (2011). Chitosan Adhesive Films for Photochemical Tissue Bonding. ...
The active ingredients in the ODC cannabis line contain the original active ingredient chitosan at 0.25%, as well as 0.28% ... "MATERIAL SAFETY DATA SHEET Colloidal Chitosan" (PDF). ODC™. "BEYOND Stoner 3x ODC™". www.aeroponics.com. Retrieved 2020-12-06. ...
Chitosan is a nontoxic polymer that has displayed broad-spectrum antimicrobial activity. The mechanism of action for chitosan ... Growth inhibition and death of fungi, bacteria, and yeasts have been seen from chitosan. The antimicrobial effect of chitosan ... Although the antimicrobial effect is attributed to antifungal properties of chitosan, it may be possible that the chitosan acts ... Chitosan has been used as a coating and appears to protect fresh vegetables and fruits from fungal degradation. ...
Chitosan was added to cryogels as it promotes spheroid formation in hepatocytes, an indicator of healthy growth. The ... investigated poly(AN-co-NVP) and poly(NiPAAm)-chitosan cryogels as hepatocyte carriers in a BAL system. These cryogel polymers ... took this system a step further, utilising HepG2 seeded poly(NiPAAm)-chitosan cryogels in a bioreactor, along with an activated ... Li, Jieliang; Pan, Jilun; Zhang, Liguo; Yu, Yaoting (June 2003). "Culture of hepatocytes on fructose-modified chitosan ...
Çetinus ŞA, Öztop HN (June 2003). "Immobilization of catalase into chemically crosslinked chitosan beads". Enzyme and Microbial ...
Implants composed of chitosan and hydroxyapatite take advantage of chitosan's biocompatibility and its ability to be molded ... The composite formed by carbon nanotubes and chitosan greatly improves the toughness of chitosan. Nanostructured artificial ... Chitosan can also be used with carbon nanotubes, which have a high Young's modulus (1.0-1.8 TPa), tensile strength (30-200 GPa ... Chitosan by itself can be easily modified into complex shapes that include porous structures, making it suitable for cell ...
Other natural biomaterials utilized include agarose and chitosan. Synthetic biomaterials include poly(ethylene glycol) (PEG) ...
ISBN 978-81-315-0104-7. Ifuku, S. (2014). "Chitin and chitosan nanofibers: preparation and chemical modifications". Molecules. ...
Song S, Zhou F, Nordquist RE, Carubelli R, Liu H, Chen WR (June 2009). "Glycated chitosan as a new non-toxic immunological ... Chen WR, Korbelik M, Bartels KE, Liu H, Sun J, Nordquist RE (2005). "Enhancement of laser cancer treatment by a chitosan- ...
"Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers". Journal of Applied Polymer Science. 63 (1): ...
"Nanostructured Hollow Tubes Based on Chitosan and Alginate Multilayers". Advanced Healthcare Materials. 3 (3): 433-440. doi: ...
Common synthetic polymeric nanoparticles include polyacrylamide, polyacrylate, and chitosan. Drug molecules can be incorporated ...
Liu X, Ma L, Mao Z, Gao C (2011), Jayakumar R, Prabaharan M, Muzzarelli RA (eds.), "Chitosan-Based Biomaterials for Tissue ... May 2013). "Ultrathin chitosan-poly(ethylene glycol) hydrogel films for corneal tissue engineering". Acta Biomaterialia. 9 (5 ... May 2012). "The use of chitosan based hydrogel for enhancing the therapeutic benefits of adipose-derived MSCs for acute kidney ... Materials such as collagen, chitosan, cellulose, and poly (lactic-co-glycolic acid) have been implemented extensively for drug ...
Xu, L.; Huang, Y.; Zhu, Q.; Ye, C. (2015). "Chitosan in molecularly-imprinted polymers: Current and future prospects". ...
Chandrasekar, Vaishnavi (2017). "Release Kinetics of Nisin from Chitosan-Alginate Complex Films". Journal of Food Science. 81 ( ...
"Critical assessment of chitosan as coagulant to remove cyanobacteria". Harmful Algae. 66: 1-12. doi:10.1016/j.hal.2017.04.011. ...
After this the chitosan polymer chain forms micro fibrils. These fibers are embedded in an amorphous matrix consisting of ... Most fungi have chitin as structural polysaccharide, while zygomycetes synthesize chitosan, the deacetylated homopolymer of ... proteins, glucans (which putatively cross-link the chitosan fibers), mannoproteins, lipids and other compounds. Trisporic acid ...
Eijsink V, Hoell I, Vaaje-Kolstada G (2010-01-01). "Structure and function of enzymes acting on chitin and chitosan". ...
"Application of low-molecular-weight chitosan in durable press finishing". Carbohydrate Polymers. 73 (2): 254-260. doi:10.1016/j ...
Chitosan Control Chitosan Control Chitosan 27. 24.17 ± 3.80. 25.30 ± 0.96. 37.2 ± 3.30† 45.90 ± 3.38‡ 38.77 ± 3.87† 88.50 ± ... Chitosan Control Chitosan Control Chitosan 27. 72.80 ± 12.74. 60.87 ± 15.90. 48.50 ± 11.00. 32.8 ± 15.50. 10.70 ± 2.54. 10.30 ... Chitosan induces different L-arginine metabolic pathways in resting and inflammatory macrophages.[3] Chitosan but not chitin ... Chitosan is one of a few natural cationic polysaccharides. A number of applications for chitosan have been proposed, including ...
The preliminary studies with the chitosan paste delivered antibiotics to a contaminated musculoskeletal wound with hardware and ... Blended Chitosan Paste for Infection Prevention: Preliminary and Preclinical Evaluations Clin Orthop Relat Res. 2017 Jul;475(7 ... We blended chitosan/polyethylene glycol (PEG) pastes/sponges to increase biocompatibility and improve antibiotic coverage ... Questions/purposes: (1) Are blended chitosan/PEG pastes biodegradable? (2) Are the blended pastes biocompatible? (3) How much ...
Optimal immobilization of β-glucosidase into chitosan beads using response surface methodology ... Optimal immobilization of β-glucosidase into chitosan beads using response surface methodology ...
For this, an optimisation process (factors: olive oil: chitosan ratio and PEITC: chitosan ratio) was implemented through a 3- ... Optimal conditions were olive oil: chitosan and PEITC: chitosan ratios of 1.46 and 0.25, respectively. These microparticles had ... So, polymeric microparticles were developed using chitosan-olive oil-PEITC systems. ...
The bioactive polymer chitosan and its NPs provide outstanding characteristics for capping and enhancements of nanometals. The ... whereas the fungal chitosan (FCt) was produced from ,i,Aspergillus brasiliensis,/i, biomass and was transformed to nanoform. ... Fungal Chitosan Extraction. The chitosan was effectually extracted from A. brasiliensis mycelia; the extracted FCt had a ... Preparation of Fungal Chitosan/TiO2-NP Composite. Grown mycelia of Aspergillus brasiliensis (ATCC-16404), after aerobic ...
Chitosan Market Size, Trends and Growth, By Grade (Pharmaceutical Grade, Industrial Grade, Food Grade), By Source (Shrimps, ... Chitosan Market. Chitosan Market Size, Trends and Growth, By Grade (Pharmaceutical Grade, Industrial Grade, Food Grade), By ...
Synthesized naproxen/chitosan nanocapsules were assessed against both Gram positive bacterial strain such as Bacillus subtilis ... Different factors affecting on the size diameter of chitosan nanoparticles such as stirring time and temperature, pH values as ... Different factors affecting on the immobilization of naproxen into chitosan nanoparticles such as time, temperature and pH ... The morphology and diameter of the prepared chitosan nanoparticles was characterized using scanning electron microscopy and ...
Clearing Wine w/ Chitosan? Hi, all! So, after waiting a month for my Gewurztraminer to clear, I decided to keel to impatience ... bcuz I only had chitosan on hand. Its now been 3 days and its cloudier than ever. What... ... and add some chitosan to it to see if it would clear without adding the other component that it reacts with, ...
Injectable Chitosan-Based Thermosensitive Hydrogel/Nanoparticle-Loaded System for Local Delivery of Vancomycin in the Treatment ... The VCM-NPs were formed with quaternary ammonium chitosan and carboxylated chitosan nanoparticles (VCM-NPs) by positive and ... We hypothesize that the positive charge of quaternary ammonium chitosan (QAC) and the negative charge of carboxylated chitosan ... Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat ...
Because Chitosan is mostly indigestible, it can then prevent ... Chitosan has the unique ability to dissolve and bind to fats ... Chitosan. Chitosan has the unique ability to dissolve and bind to fats and cholesterol in the stomach. Because Chitosan is ... Chitin and chitosan are also now being taken like acidophilus, FOS, and other supplements to speed the transit of foods through ... Chitin and chitosan are nontoxic and free of side effects, although they share the same precautions for safe use that apply to ...
Sustained and controlled ocular delivery can be achieved with chitosan based formulations like chitosan gels, inserts, chitosan ... Sustained and controlled ocular delivery can be achieved with chitosan based formulations like chitosan gels, inserts, chitosan ... This review discussed various aspects related to chitosan and chitosan based formulations particularly developed for ocular ... This review discussed various aspects related to chitosan and chitosan based formulations particularly developed for ocular ...
The Maillard reaction product of chitosan and glucose extended the shelf-life of lamb in laboratory tests by two weeks, and may ... "From the present studies that the chitosan-glucose complex (CGC) is a better preservative than chitosan alone. It showed ... Chitosan-glucose combo eyed as novel preservative. By Stephen Daniells 29-Aug-2007. - Last updated on 19-Jul-2008 at 10:07. GMT ... The Maillard reaction product of chitosan and glucose extended the shelf-life of lamb in laboratory tests by two weeks, and may ...
Direct electrochemistry and electrocatalysis of hemoglobin immobilized in a magnetic nanoparticles-chitosan film. Download ... AnimalsBiosensing TechniquesCatalysisCattleChitosanElectrochemistryElectrodesElectron TransportFerrosoferric OxideHemoglobins ... The Fe(3)O(4) nanoparticles and chitosan (CS) were mixed to form a matrix in which haemoglobin (Hb) can be immobilized for the ... The Fe(3)O(4) nanoparticles and chitosan (CS) were mixed to form a matrix in which haemoglobin (Hb) can be immobilized for the ...
Home » chitosan. Articles tagged with: chitosan. Bionics». Using injectable nano-network and ultrasound to help diabetics. By ... Tags: blood sugar levels, chitosan, diabetics, glucose levels, nanotechnology, north carolina state university, seaweed, shrimp ... researchers in Asia successfully managed to extract polymer chitosan from shrimp shells in order to make filters, foils and ...
... and uses of chitosan to control the process. ... Applications of Chitosan during the harvest. Applications of ... The use of chitosan is already widespread due to its effectiveness in microbiological control, but new applications are still ... The authorization of the use of chitosan in oenology has opened the door to a new range of products with antimicrobial action. ... Chitosan during the harvest. Recording of the webinar held by Luis Cotanda. ...
US-2019000794-A1 chemical patent summary.
Mannosylated Chitosan-zinc Sulphide Nanocrystals as Fluorescent Bioprobes for Targeted Cancer Imaging. Publication Type : ... Abstract : A novel nanomaterial based on chitosan-zinc sulphide:Mn (ZnS:Mn) conjugated with mannose ligand has been developed ... Deepthy Menon, "Mannosylated Chitosan-zinc Sulphide Nanocrystals as Fluorescent Bioprobes for Targeted Cancer Imaging", ... HomePublicationsMannosylated Chitosan-zinc Sulphide Nanocrystals as Fluorescent Bioprobes for Targeted Cancer Imaging ...
... and HZSM-5 were incorporated into chitosan (CS) matrix to fabricate the hybrid membranes for direct methanol fuel cell (DMFC). ... Effect of zeolites on chitosan/zeolite hybrid membranes for direct methanol fuel cell *Wang, Jingtao ... Zeolites including 3A, 4A, 5A, 13X, mordenite, and HZSM-5 were incorporated into chitosan (CS) matrix to fabricate the hybrid ...
Inhibition of fibrillation of human serum albumin through interaction with chitosan-based biocompatible silver nanoparticles† ... Inhibition of fibrillation of human serum albumin through interaction with chitosan-based biocompatible silver nanoparticles S ... The experimental observations indicate that interactions between HSA and chitosan-based silver nanoparticles have led to ... The results illustrate that the chitosan-mediated silver nanoparticles spontaneously bind to HSA without appreciable ...
Characterization of chitosan by steric exclusion chromatography. Polymer, 42 (25), pp. 9921-9927. ISSN 0032-3861 ...
... chitosan Remove constraint Subject: chitosan Subject term chitosan Remove constraint Subject term: chitosan Start Over ... Henn (Pgt),as well as chitin oligosaccharides, chitosan, and methyl jasmonate (MJ) stimulated lipoxygenase (LOX) activity (E.C ... protein synthesis; dose response; chitosan; seedlings; jasmonic acid; linoleate 13S-lipoxygenase; Puccinia graminis; Triticum ...
Palabras clave: ACTIVE EDIBLE FILMS , ANTIFUNGAL AGENT , CROSSLINKING AGENT , WATER SOLUBLE CHITOSAN , WHEY PROTEIN ISOLATE ... Antifungal whey protein films activated with low quantities of water soluble chitosan. .noexiste{ color: #000; } .imagenItem{ ... added with low quantities of a water soluble derivative of chitosan (WSCh), which was obtained through a Maillard reaction with ... Antifungal whey protein films activated with low quantities of water soluble chitosan; Elsevier; Food Hydrocolloids; 110; ...
... chitosan is natural polymer used as potential carrier for many drugs and also for many drug delivery such as topical, ... The objective of following review is to elaborate chitosan microsphere, ... The objective of following review is to elaborate chitosan microsphere, chitosan is natural polymer used as potential carrier ... Colon Targeted Delivery, Chitosan, Ulcerative Colitis, Microsphere, Mechanism Of Drug Release. Communities:. *INDO AMERICAN ...
Probing insulins secondary structure after entrapment into alginate/chitosan nanoparticles. Research output: Contribution to ... Probing insulins secondary structure after entrapment into alginate/chitosan nanoparticles. / Sarmento, B.; Ferreira, D. C.; ... Probing insulins secondary structure after entrapment into alginate/chitosan nanoparticles. European Journal of Pharmaceutics ... Probing insulins secondary structure after entrapment into alginate/chitosan nanoparticles. In: European Journal of ...
Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for ... Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for ... Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for ... Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for ...
I forgot to add Chitosan! Hey forum, I am on my third kit, a Pinot Noir. Just realized I forgot to add Chitosan. I am at a step ...
Eudragit® L100/chitosan composite thin bilayer films for intravaginal pH-responsive release of Tenofovir ... In all the cases films structured in two layers - the upper layer mainly attributed to EL100 and the lower layer to chitosan - ... Bilayer films, Chitosan-based films, Eudragit® L100-based films, Films mechanical properties, Mucoadhesive vaginal films, ... Six batches of Tenofovir-loaded films were formulated based on Eudragit® L100 (EL100) and chitosan, containing triethyl citrate ...
In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using GastroPlus™. Authors: Praveen R, ... In conclusion, the study showed that gastro-retentive controlled release system prepared using chitosan could be a potential ... chitosan. 32 full factorial design was adopted for optimization of tripolyphosphate (X1) and curing time (X2). Bead stability ...
  • The VCM-NPs were formed with quaternary ammonium chitosan and carboxylated chitosan nanoparticles (VCM-NPs) by positive and negative charge adsorption to enhance the encapsulation efficiency and drug loading of VCM, with the aim of simultaneously preventing infection and repairing broken bones. (dovepress.com)
  • Sustained and controlled ocular delivery can be achieved with chitosan based formulations like chitosan gels, inserts, chitosan coated liposome/niosome and chitosan nanoparticles. (eurekaselect.com)
  • The Fe(3)O(4) nanoparticles and chitosan (CS) were mixed to form a matrix in which haemoglobin (Hb) can be immobilized for the fabrication of H(2)O(2) biosensor. (unboundmedicine.com)
  • The heterogeneous electron transfer rate constant (k(s)) was 1.04 s(-1), indicating great facilitation of the electron transfer between Hb and magnetic nanoparticles-chitosan modified electrode. (unboundmedicine.com)
  • In this work, the mechanistic detail of the interaction between human serum albumin (HSA) and silver nanoparticles synthesized using nontoxic and biodegradable chitosan as a reducing and stabilizing agent, have been investigated at the nanobio interface. (rsc.org)
  • The results illustrate that the chitosan-mediated silver nanoparticles spontaneously bind to HSA without appreciable conformational changes of the protein. (rsc.org)
  • The experimental observations indicate that interactions between HSA and chitosan-based silver nanoparticles have led to appreciable reduction in amyloid fibril formation. (rsc.org)
  • In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. (muni.cz)
  • Barrier function measurements employing electric cell-substrate impedance sensing and analyses of tight junction-specific protein profiles have indicated that the alkylglyceryl-modified chitosan nanoparticles impact upon the integrity of the model blood-brain barrier, whereas confocal microscopy experiments have demonstrated the efficient cellular uptake and the perinuclear localization of these nanoparticles. (port.ac.uk)
  • Munin: Chitosan Lecithin Nanoparticles with New Chemical Entity. (uit.no)
  • A new chemical entity (NCE) encapsulated in chitosan/lecithin nanoparticles as well as NCE as a free drug was evaluated for potential cytotoxic effects by an in vitro MTT assay performed on HaCaT cells. (uit.no)
  • IMSEAR at SEARO: Fabrication and Characterization of chitosan based polymeric Escitalopram nanoparticles. (who.int)
  • The present study is focused on developing and characterizing chitosan based nanoparticles of Escitalopram oxalate (ETP). (who.int)
  • Materials and Methods: The nanoparticles were prepared by ionic gelation method using chitosan and tripolyphosphate (TPP). (who.int)
  • Conclusion: ETP loaded chitosan nanoparticles were prepared successfully from ionic gelation method, suggesting a comparatively suitable option for treatment of disease with fewer side effects and increased affinity of drug. (who.int)
  • Herein, we present a microwave-assisted easy in situ solution casting approach for the manufacture of strontium oxide nanoparticles doped within a naturally occurring polymer, chitosan (CS), at varying weight percentages (2.5, 5, 10, 15, and 20 wt. (bvsalud.org)
  • The results of the characterization of bioplastic films with the best performance are the addition of 7 mL sorbitol with a percentage of chitosan 4% with the result of 4.27 kgf / mm2 for tensile strength, 14% for elongation, percentage for water resistance of 90.6%, and positive friendly environment with biodegradability of bioplastic films as a whole for 6 days. (ummi.ac.id)
  • Chitosan, produced by deacetylation of chitin, which is the structural element in the exoskeleton of crustaceans such as crab, shrimp, and crawfish and the cell wall of fungi, is a natural nontoxic biopolymer. (medscape.com)
  • [ 3 ] Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. (medscape.com)
  • Chitin and chitosan were packed into nylon bags (3×1 cm2, 45 μm mesh) and administered orally, and then the bags were recovered from the feces. (researchgate.net)
  • The present study showed that chitin did not undergo any changes in weight and shape in the gastrointestinal tract, whereas chitosan did. (researchgate.net)
  • Chitin and chitosan are also now being taken like acidophilus , FOS, and other supplements to speed the transit of foods through the digestive system and to promote the growth of beneficial live bacteria in the intestines. (digitalnaturopath.com)
  • Chitin (pronounced kite-in) and chitosan (kite-o-san) are fibers derived from marine animals. (digitalnaturopath.com)
  • It is used to make various other substances, including chitosan, which is derived from chitin by heating it with a chemical solution. (digitalnaturopath.com)
  • Chitosan, has the advantage of being more soluble in water than chitin Scientists have intensively investigated the properties and uses of chitin, chitosan, and their derivatives - collectively they are the subjects of approximately 1,000 scientific studies and hundreds of patents. (digitalnaturopath.com)
  • Chitin and chitosan are nontoxic and free of side effects, although they share the same precautions for safe use that apply to other types of fiber. (digitalnaturopath.com)
  • Chitin and chitosan should be taken separately from EFA supplements and vitamins, and before a high-fat or high-calorie meal. (digitalnaturopath.com)
  • Although chitin and chitosan are considered non-allergenic, people with shellfish allergies should not take them, nor should pregnant or breastfeeding women. (digitalnaturopath.com)
  • Aside efforts to utilize crustacean shells by extracting chitin and turning it into pharmaceuticals with fungi, researchers in Asia successfully managed to extract polymer chitosan from shrimp shells in order to make filters, foils and wound dressings. (robaid.com)
  • Henn (Pgt),as well as chitin oligosaccharides, chitosan, and methyl jasmonate (MJ) stimulated lipoxygenase (LOX) activity (E.C. 1.13.11.12) in wheat (Triticum aestivum) leaves. (usda.gov)
  • Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. (wileyiran.com)
  • Chitin and Chitosan Preparation from Marine Sources. (semanticscholar.org)
  • Chitin and chitosan are considerably versatile and promising biomaterials. (semanticscholar.org)
  • Implantable applications of chitin and chitosan. (semanticscholar.org)
  • The bioactive polymer chitosan and its NPs provide outstanding characteristics for capping and enhancements of nanometals. (hindawi.com)
  • The polymer hydrogel treatment contains the naturally occurring polymer chitosan, extracted from shrimp shells, functionalized with a host molecule, cucurbit[8]uril , to form a cross-linked polymer network which provide structural stability. (creativepegworks.com)
  • And low-molecular-weight chitosan (LC) is one of chitosan derivatives and maintain beneficial biological properties of chitoson. (biomedcentral.com)
  • Chitosan-Based Systems for Biopharmaceuticals provides a concise and up-to-date overview of the application of chitosan and its derivatives in the development and optimization of biopharmaceutical medicinal products. (wileyiran.com)
  • We engineered a chitosan (CS)-based thermosensitive hydrogel to produce a VCM-nanoparticle (NPs)/Gel local drug delivery system. (dovepress.com)
  • Fungal Carboxymethyl Chitosan-Impregnated Bacterial Cellulose Hydrogel as Wound-Dressing Agent. (bvsalud.org)
  • Thermosensitive chitosan-gelatin-glycerol phosphate hydrogel as a controlled release system of ferulic acid for nucleus pulposus regeneration. (channel969.com)
  • Thus, the acellular, chitosan-based biomaterial is a promising biopolymer composite for the treatment of chondral and osteochondral defects of traumatic character. (nurch.sk)
  • We developed hydrogels by impregnating fungal-derived carboxymethyl chitosan to BC fiber networks using a simple solution immersion method . (bvsalud.org)
  • 1) Are blended chitosan/PEG pastes biodegradable? (nih.gov)
  • Chitosan, a non-toxic, biodegradable and biocompatible polysaccharide has attained great interest in pharmaceutical applications, as versatile drug delivery agent. (biomedcentral.com)
  • Therefore, bioplastic films have been made from corn cellulose by adding sorbitol and chitosan as environmentally friendly plastic or biodegradable plastic. (ummi.ac.id)
  • The effect of chitosan on macrophages has been extensively studied. (medscape.com)
  • Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development. (wileyiran.com)
  • Chitosan is a polysaccharide composed of D-glucosamine (2-amino-2-deoxy-β-D-glucose) and N -acetyl-D-glucosamine (2-acetamido-2-deoxy-β-D-glucose) (Figure 1 ). (biomedcentral.com)
  • To further help with this, the researchers used chitosan, a polysaccharide found in crustacean shells, as a binder. (newenergyandfuel.com)
  • Click the button below to add the Carboxymethyl chitosan 1g to your wish list. (p212121.com)
  • Tension administration is also highly urged from companies that offer healthy and balanced cholesterol - all-natural different Carboxymethyl chitosan powder . (bamboo-parc.com)
  • The concept is a biphasic construct consisting of a porous, osteoconductive chitosan-calcium phosphate scaffold supporting a layer of neocartilage formed by marrow-derived mesenchymal stem cells. (openorthopaedicsjournal.com)
  • Use of hybrid chitosan membranes and human mesenchymal stem cells from the Wharton jelly of umbilical cord for promoting nerve regeneration in an axonotmesis rat model. (bvsalud.org)
  • Our blended paste/sponge formulations (0.5% acidic, 1% acidic, and acidic/neutral) along with a control neutral 1% chitosan sponge were tested in vitro for degradability, cytocompatibility, injectability tested by determining the amount of force needed to inject the pastes, elution of antibiotics, and activity tested using zone of inhibition studies. (nih.gov)
  • An in vitro study was also performed to investigate the physical change of chitosan after treatment with artificial gastric and intestine juices. (researchgate.net)
  • The in vitro study showed that chitosan became a gel in artificial gastric juice and its weight decreased by 15%, but there were no such physical changes when it was placed in artificial intestinal juice. (researchgate.net)
  • Evaluar in vitro la modificación hidrofoba del esmalte como método preventivo en contra de la desmineralización. (bvsalud.org)
  • Chitosan is a valuable material known for its antibacterial, anti-inflammatory, immune boosting, antioxidant and biocompatible properties. (trendlines.com)
  • Chitosan is one of a few natural cationic polysaccharides. (medscape.com)
  • It is clear that chitosan is a cationic macromolecular surfactant with special structure and properties. (pku.edu.cn)
  • The objective of the present experiment, therefore, was to clarify the effects of low-molecular-weight chitosan on the growth performance, incidence of diarrhea, intestinal morphology, barrier function, immune response, and antioxidant system in weaned piglets. (biomedcentral.com)
  • The LC (molecular weight 20 to 30 kDa), which was obtained from chitosan by radiation pyrolysis technology, was offered by Jiaxing Korui Biotech Co., Ltd., Zhejiang, China. (biomedcentral.com)
  • OBJECTIVE: To compare the efficacy of a 12-week treatment regimen with HEP-40TM low-molecular weight chitosan given at daily doses of 1,200 mg, 1,600 mg, and 2,400 mg in reducing serum low-density lipoprotein cholesterol (LDL-C) in patients with low-to-moderate hypercholesterolemia. (altmedrev.com)
  • CONCLUSION: HEP-40 low-molecular weight chitosan, although not as effective as statins, is efficacious and safe in lowering LDL-C concentrations in treatment- naive patients with low-to-moderate hypercholesterolemia. (altmedrev.com)
  • In four experimental sheep, both defects were subsequently filled with the porous acellular polyhydroxybutyrate/chitosan (PHB/CHIT) - based implant. (nurch.sk)
  • When testing the antimicrobial activity of the complex against E. coli, Pseudomonas, Staphylococcus aureus ​ and Bacillus cereus ​, the common food spoilage and pathogenic bacteria, Kanatt and co-workers report that the activity of CGC was similar to chitosan, with a minimum inhibition at concentrations of 0.05 per cent. (foodnavigator-usa.com)
  • Chitosan is a dietary fiber from shellfish. (medlineplus.gov)
  • Today, chitosan extraction from shellfish involves chemical processes and large amounts of water, making it unsustainable. (trendlines.com)
  • In experiment 1, the results showed that the immune response, such as Newcastle disease antibody and CD4 + T cells, would be significantly activated by feeding with chitosan and its derivative during 27 days. (medscape.com)
  • However, the mortality of broilers was significantly decreased, while feed intake and weight gain of the birds were significantly increased in the group treated with chitosan and its derivative as compared with other groups. (medscape.com)
  • Chitosan and its derivative have strong potential in immune enhancement and disease control, and can be used as a feed additive. (medscape.com)
  • [ 5 ] This study was conducted to evaluate the concentration of the Newcastle disease (ND) antibody, CD3 + , CD4 + and CD8 + lymphoid cells, immune factors, diarrhea, respiratory symptoms and mortality of yellow-feathered broilers fed with chitosan and its derivative in water. (medscape.com)
  • Levels of Newcastle disease antibody in broilers fed with chitosan derivative during 27, 30 and 35 days. (medscape.com)
  • The aim of this work was to develop antifungal films from whey protein isolate (WPI) added with low quantities of a water soluble derivative of chitosan (WSCh), which was obtained through a Maillard reaction with glucosamine hydrochloride. (conicet.gov.ar)
  • In this work, we developed an alginate/chitosan membrane sufficiently stable in a simulated vaginal fluid and able to dissolve over time at a very slow and linear rate. (dtu.dk)
  • Metronidazole was effectively included in the alginate/chitosan membrane and its bactericide effect was demonstrated against Staphylococcus aureus and Gardnerella vaginalis, simultaneously showing good biocompatibility with a cervix epithelial cell line. (dtu.dk)
  • Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for the controlled release of a model drug, it represents a promising drug delivery system for local intravaginal applications. (dtu.dk)
  • Fourier Transform Infrared Spectroscopy (FTIR) results showed that there was N-H bonding and O-H bonding in chitosan film. (unimap.edu.my)
  • The strontium oxide-chitosan nanocomposites were characterized using Fourier transform infrared (FTIR), X-ray diffraction (XRD), and scanning electron microscope (SEM) techniques. (bvsalud.org)
  • In 3 studies, weight loss was not measured, but there was no evidence that chitosan blocked fat absorption from the intestines or fat excretion in the feces. (thecamreport.com)
  • Chitosan is a pulverized powder made from the shells of shrimp and crab. (thecamreport.com)
  • In the present study, the efficiency of chitosan-clay nano-composite coating on some quality propertiesof lemon was investigated during cold storage. (cigrjournal.org)
  • Based on the results of present study, the quality properties of lemon fruit samples was improved after coating with chitosan-clay nano-composite during storage. (cigrjournal.org)
  • To overcome such an issue, the researchers created an unique family of nano-crystalline metal oxyhydroxide-chitosan granular composite materials. (dcncorp.com)
  • Insectta transforms food waste by returning it into the economy as valuable biomaterials (for example, chitosan) by utilizing the black soldier fly (hermetia illucens). (trendlines.com)
  • In conclusion, the study showed that gastro-retentive controlled release system prepared using chitosan could be a potential drug carrier of carvedilol with improved bioavailability. (simulations-plus.com)
  • Chitosan powder was dissolved in 2% of acetic acidand blended with ferredoxin. (unimap.edu.my)
  • Zeolites including 3A, 4A, 5A, 13X, mordenite, and HZSM-5 were incorporated into chitosan (CS) matrix to fabricate the hybrid membranes for direct methanol fuel cell (DMFC). (harvard.edu)
  • However, chitosan is restricted to be used in food and biomedical applications because of its difficult solubility and instability [ 10 ]. (biomedcentral.com)
  • 5 kDa) are obtained from chitosan by physical, chemical or enzymatic methods, and have much higher solubility and stability than chitosan. (biomedcentral.com)
  • The main constituent of LipoSan Ultra® is Chitosan, which has been modified and optimized to improve its binding, solubility and fat performance. (vivasaudavel.pt)
  • The fate and toxicological consideration related to chitosan, resulting with its interaction to ocular tissues, has also been summed up in addition. (eurekaselect.com)
  • The phytosynthesis of TiO 2 -NPswas promisingly achieved using an extract of pomegranate rind, whereas the fungal chitosan (FCt) was produced from Aspergillus brasiliensis biomass and was transformed to nanoform. (hindawi.com)
  • Material and Methods: To obtain the chitosan spheres and the chitosan with crude ethanolic extract of mastruz (CEE) the Ionotropic gelation technique was used. (bvsalud.org)
  • Writing in the journal Food Chemistry ​, lead author Sweetie Kanatt from the Bhabha Atomic Research Centre in Mumbai report that by heating chitosan with glucose produces a chitosan-glucose complex (CGC) via the Maillard reaction, and this complex has excellent antioxidant and antimicrobial activity. (foodnavigator-usa.com)
  • En: Starch: Chemistry and Technology. (rmiq.org)
  • A series of O-substituted alkylglyceryl chitosans with systematically varied alkyl chain length and degree of grafting has been employed for the formulation of aqueous nanoparticulate systems, which were in turn investigated for their effects on a modeled blood-brain-barrier system of mouse-brain endothelial cells. (port.ac.uk)
  • Measurements of surface tension, conductivity, aggregation behavior and solubilization of pyrene of chitosan aqueous solutions have been carried out. (pku.edu.cn)
  • Nevertheless, there is a lack of reports concerning complexing equilibria in aqueous solution, in particular when using the more advantageous microcrystalline form of chitosan (MCCh). (biomedcentral.com)
  • A polymer of desired chemical properties is prepared by appropriate aggregation of the macromolecules from aqueous solutions of organic acids (via neutralization, coagulation and then precipitation of microcrystalline chitosan) [ 8 ]. (biomedcentral.com)
  • Chitosan being a polycationic in nature interacts with the polyanionic surface of ocular mucosa through hydrogen bonding /ionic interactions and enhance the mucoadhesive effect of formulation. (eurekaselect.com)
  • To make the cathode, the researchers spread a slurry of the nitrogen-doped carbon materials, chitosan binder, and elemental sulfur on aluminum foil and topped it with a net made of nanotubes to act as a final barrier to keep polysulfides from escaping. (newenergyandfuel.com)
  • The antimicrobial activity of the CGC was identical to that of chitosan against the common food spoilers and pathogens such as E. coli, Pseudomonas spp, S. aureus and B. cereus. (foodnavigator-usa.com)
  • The authorization of the use of chitosan in oenology has opened the door to a new range of products with antimicrobial action. (infowine.com)
  • LipoSan ULTRA® - high density of Chitosan, fiber that binds up to five times more to fat than conventional Chitosan. (vivasaudavel.pt)
  • This review discussed various aspects related to chitosan and chitosan based formulations particularly developed for ocular therapeutics. (eurekaselect.com)
  • The molar D-glucosamine to N -acetyl-D-glucosamine ratio in the chitosan sample is an estimate of the so called degree of deacetylation (DD). (biomedcentral.com)
  • [ 2 ] The chemical structure of chitosan is similar to that of cellulose, with polymeric 1,4-linked 2-amino-2-deoxy- D -glucose. (medscape.com)
  • Our goal is to create a bilayered construct which consists of an osteoconductive chitosan-calcium phosphate scaffold underlying a layer of neocartilage formed bymesenchymal stem cells (MSCs) through self-assembly. (openorthopaedicsjournal.com)
  • The global chitosan market is valued at USD 7 billion and is expected to expand at a CAGR of 25% between 2020 and 2030. (trendlines.com)
  • Chitosan is ineffective when serum-supplemented medium is used, suggesting that serum may contain a factor(s) that influences IgM production by lymphocytes. (medscape.com)
  • Mean serum cholesterol went down 43% and mean serum hemoglobin increased from 5.8 to 6.8 g/dl in those patients who received the chitosan. (digitalnaturopath.com)
  • 001 to 0.875 mM) levels in serum showed significant reductions after 12 weeks of chitosan treatment. (digitalnaturopath.com)
  • We blended chitosan/polyethylene glycol (PEG) pastes/sponges to increase biocompatibility and improve antibiotic coverage within the wound. (nih.gov)
  • The preliminary studies demonstrated promising results for the blended chitosan/PEG pastes with antibiotics provided degradability, biocompatibility, injectability, and infection prevention for musculoskeletal-type wounds. (nih.gov)
  • In addition, chitosan was found to be affected in the stomach and large intestine, but not in the small intestine. (researchgate.net)
  • Chitosan has the unique ability to dissolve and bind to fats and cholesterol in the stomach . (digitalnaturopath.com)
  • The Maillard reaction product of chitosan and glucose extended the shelf-life of lamb in laboratory tests by two weeks, and may offer industry with a novel and efficient preservative for meat products. (foodnavigator-usa.com)
  • From the present studies that the chitosan-glucose complex (CGC) is a better preservative than chitosan alone. (foodnavigator-usa.com)
  • 2002: Chitosan supplements failed to increase fecal fat content and therefore did not block fat absorption. (thecamreport.com)
  • Weight loss was the most dramatic result from a Helsinki Chitosan clinical pilot study. (digitalnaturopath.com)
  • The objective of present investigation was to develop gastro-retentive controlled release system of carvedilol using biological macromolecule, chitosan. (simulations-plus.com)
  • Most study results dispute the claim that chitosan is a "fat blocker. (thecamreport.com)
  • More importantly, the best results occurred when chitosan was combined with support from other dieters and healthcare professionals. (thecamreport.com)
  • Scanning Electron Microscope (SEM) results showed that the surface of chitosan-ferredoxin film is smoother and more compact than chitosan film. (unimap.edu.my)
  • The results show that chitosan is surface-active, and can aggregate in single molecule, or critical aggregation number cac≈ 0. (pku.edu.cn)
  • In addition to developing a new source of sustainable chitosan for the industry, Insectta's proprietary extraction process also results in a purer, cleaner, and higher-grade chitosan as compared to traditional sources. (trendlines.com)
  • All the results confirmed the formation of chitosan-strontium oxide nanocomposite. (bvsalud.org)