A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.
A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.
Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.
A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.

Molecular heterogeneity and function of EWS-WT1 fusion transcripts in desmoplastic small round cell tumors. (1/21)

Desmoplastic small round cell tumor (DSRCT) is a primitive sarcoma with a consistent cytogenetic abnormality, t(11;22)(p13;q12). This chromosomal translocation generates a chimeric transcript that is formed by fusion of the 5' region of the Ewing's sarcoma gene, EWS, with the 3' DNA-binding segment of WT1, the Wilms' tumor suppressor gene. We collected 14 DSRCT tumor samples and examined the hybrid transcripts. We identified: (a) combinatorial heterogeneity of EWS exons fused to WT1 including use of EWS exons 7, 8, and 9; (b) subpopulations of variant transcripts in 6 of 14 tumors characterized by aberrant splicing resulting in loss of EWS exon 6 or WT1 exon 9; (c) multiple cDNA products with large internal deletions; and (d) insertion of small stretches of heterologous DNA at the fusion site or exon splice region in transcripts from two tumors. Most of the splice variants were in-frame, and in vitro translated fusion proteins with intact DNA-binding motifs formed complexes with a WT1 response element in gel mobility assays. Each of the chimeric proteins retains the ability to bind to the GC and TC elements of the early transcription factor EGR-1 as well as WT1 consensus sequences. We present evidence that various EWS-WT1 proteins up-regulated EGR-1 promoter activity and that this up-regulation is specifically dependent upon the absence of the exon 9 KTS domain of WT1. The molecular diversity and functionality exhibited by these fusion transcripts may have significant biological implications for their transactivating and tumorigenic potential.  (+info)

Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. (2/21)

In patients with localized prostate cancer, radical prostatectomy and radiation therapy, although effective in controlling localized disease, are often associated with significant side effects attributable to injury of adjacent tissues. Moreover, patients with metastatic disease eventually fail systemic hormonal or chemotherapy because of the development of progressive, refractory disease. In this study, we evaluated the safety and efficacy of a novel suicide gene therapy that could potentially spare normal tissue while bypassing molecular mechanisms of apoptosis resistance by using chemically inducible effector caspases to trigger apoptosis in prostate cancer cells. Initially, we compared the ability of a panel of inducible Fas signaling intermediates to kill human and murine prostate cancer cell lines. On the basis of the superior killing by downstream caspase-1 and caspase-3, replication-deficient adenoviral vectors expressing conditional caspase-1 (Ad-G/iCasp1) or caspase-3 (Ad-G/iCasp3), regulated by nontoxic, lipid-permeable, chemical inducers of dimerization (CID), were constructed. Upon vector transduction followed by CID administration, aggregation and activation of these recombinant caspases occur, leading to rapid apoptosis. In vitro, both human (LNCaP and PC-3) and murine (TRAMP-C2 and TRAMP-C2G) prostate cancer cell lines were efficiently transduced and killed in a CID-dependent fashion. In vivo, direct injection of Ad-G/iCasp1 into s.c. TRAMP-C2 tumors caused focal but extensive apoptosis without evidence for a bystander effect at the maximal viral dose (i.e., 2.5 x 10(10) viral particles/25 microl) in host animals that also received CID compared with control animals. Treatment with Ad-G/iCasp1 plus CID resulted in a transient, yet significant, reduction both in tumor growth and volume compared with tumors treated with vector but not CID (P < 0.035) or vector-diluent plus CID (P < 0.022), both of which grew more rapidly. These results demonstrate that CID-regulated, caspase-based suicide gene therapy is safe and can inhibit the growth of experimental prostate cancer in vitro and in vivo through potent induction of apoptosis, providing a rationale for further development.  (+info)

Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. (3/21)

The regulation and function of chimaerins, a family of "non-protein kinase C" (PKC) phorbol ester/diacylglycerol receptors with Rac-GAP activity, is largely unknown. In a search for chimaerin-interacting proteins, we isolated Tmp21-I (p23), a protein localized at the perinuclear Golgi area. Remarkably, phorbol esters translocate beta2-chimaerin to the perinuclear region and promote its association with Tmp21-I in a PKC-independent manner. A deletional analysis revealed that the C1 domain in chimaerins is required for the interaction with Tmp21-I, thereby implying a novel function for this domain in protein-protein associations in addition to its role in lipid and phorbol ester binding. Our results support the emerging concept that multiple pathways transduce signaling by phorbol esters and revealed that, like PKC isozymes, chimaerins are subject to a positional regulation. In this setting, Tmp21-I serves as an anchoring protein that determines the intracellular localization of these novel phorbol ester receptors.  (+info)

A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis. (4/21)

Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We constructed a chimeric receptor (VEGFR2Fas) combining the extracellular and transmembrane domains of VEGFR-2 with the cytoplasmic domain of Fas receptor. When VEGFR2Fas was stably expressed in endothelial cells in vitro, treatment with VEGF rapidly induced cell death with features characteristic of Fas-mediated apoptosis. These findings demonstrate that VEGFR2Fas functions as a VEGF-triggered death receptor and raise the possibility that introduction of VEGFR2Fas into tumor endothelium or tumor cells in vivo may convert tumor-derived VEGF from an angiogenic factor into an antiangiogenesis agent.  (+info)

The exosome pathway in K562 cells is regulated by Rab11. (5/21)

During maturation, reticulocytes lose some membrane proteins that are not required on the mature red cell surface. The proteins are released into the extracellular medium associated with vesicles that are formed by budding of the endosomal membrane into the lumen of the compartment; this process results in the formation of multivesicular bodies (MVBs). Fusion of MVBs with the plasma membrane results in secretion of the small internal vesicles, termed exosomes. K562 cells release exosomes with similar characteristics to reticulocyte exosomes, in particular the transferrin receptor (TfR) is found associated with the vesicles. Interestingly, this cell line has been shown to possess high amounts of Rab11 compared with other Rab proteins. To assess the regulation of transferrin receptor release via exosome secretion by Rab11 in this cell type, K562 cells were stably transfected with GFP-Rab11wt or the GTP- and GDP-locked mutants. The distribution of the proteins was assessed by fluorescence microscopy. Transferrin recycling and the number of TfRs present on the surface of the transfected cells were reduced by overexpression of either Rab11wt or the mutants. The amount of released exosomes was analyzed by measuring different molecular markers present on these vesicles either biochemically or by western blot. Overexpression of the dominant-negative mutant Rab11S25N inhibited exosome release, whereas the secretion of exosomes was slightly stimulated in cells transfected with Rab11wt. Taken together, the results demonstrate that in K562 cells Rab11 modulates the exosome pathway although the exact step involved is still not known.  (+info)

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. (6/21)

Diacylglycerol is an essential second messenger in mammalian cells. The most prominent intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong to the protein kinase C (PKC) family. However, at least five alternative types of high-affinity diacylglycerol/phorbol-ester receptor are known: chimaerins, protein kinase D, RasGRPs, Munc13s and DAG kinase gamma. Recent evidence indicates that these have functional roles in diacylglycerol second messenger signalling in vivo and that several cellular processes depend on these targets rather than protein kinase C isozymes. These findings contradict the still prevalent view according to which all diacylglycerol/phorbol-ester effects are caused by the activation of protein kinase C isozymes. RasGRP1 (in Ras/Raf/MEK/ERK signalling) and Munc13-1 (in neurotransmitter secretion) are examples of non-PKC diacylglycerol/phorbol-ester receptors that mediate diacylglycerol and phorbol-ester effects originally thought to be caused by PKC isozymes. In the future, pharmacological studies on PKC must be complemented with alternative experimental approaches to allow the separation of PKC-mediated effects from those caused by alternative targets of the diacylglycerol second messenger pathway. The examples of RasGRP1 and Munc13-1 show that detailed genetic analyses of C(1)-domain-containing non-PKC diacylglycerol/phorbol-ester receptors in mammals are ideally suited to achieve this goal.  (+info)

Enhancing major histocompatibility complex class I antigen presentation by targeting antigen to centrosomes. (7/21)

Several strategies that increase proteasomal degradation of antigen have been shown to improve MHC class I presentation of antigen. Because recent studies have demonstrated that the centrosome is a subcellular compartment rich in proteasomes, we hypothesized that targeting a tumor antigen to centrosomal compartments would enhance both the MHC class I presentation of antigen and the vaccine potency. We, therefore, created a chimera of gamma-tubulin, an established centrosomal marker, with a model tumor antigen, human papillomavirus type 16 (HPV-16) E7, in a DNA vaccine. The linkage of gamma-tubulin to E7-targeted antigen to centrosomal compartments, resulted in enhanced MHC class I presentation of E7, and led to a marked increase in the number of E7-specific CD8(+) T-cell precursors as well as a potent CD4-independent antitumor effect against an E7-expressing tumor cell line, TC-1. In addition, vaccination with gamma-tubulin/E7 DNA in transporter associated with antigen presentation (TAP)-1-knockout mice revealed that the enhancement of E7-specific CD8(+) T-cell immune responses is TAP-1-dependent. Our data suggest that the centrosome may be an important locus for MHC class I antigen processing and that targeting antigen to the centrosome can improve DNA vaccine potency.  (+info)

Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications. (8/21)

Phorbol esters, natural compounds that mimic the action of the lipid second messenger diacylglycerol (DAG), are known to exert their biological actions through the activation of classical and novel protein kinase C (PKC) isozymes. Phorbol esters, via binding to the PKC C1 domains, cause major effects on mitogenesis by controlling the activity of cyclin-cdk complexes and the expression of cdk inhibitors. In the last years it became clear that phorbol esters activate other molecules having a C1 domain in addition to PKCs. One of the most interesting families of "non-kinase" phorbol ester receptors is represented by the chimaerins, lipid-regulated Rac-GAPs that modulate actin cytoskeleton reorganization, migration, and proliferation. The discovery of the chimaerins and other "non-kinase" phorbol ester receptors has major implications in the design of agents for cancer therapy.  (+info)

Chimerin proteins are a group of intracellular signaling proteins that contain a protein kinase C (PKC) phosphorylation site and a GTPase-activating protein (GAP) domain, which regulates Rho GTPases. These proteins play important roles in various cellular processes such as neurite outgrowth, axon guidance, and synaptic plasticity. They are named "chimerin" because they contain domains derived from two different proteins: the N-terminal region is similar to that of a neuronal protein called semaphorin 4D, while the C-terminal region contains the GAP domain found in Ras GTPase-activating proteins. There are several isoforms of chimerin proteins, including Chimerin1 (Chn1), Chimerin2 (Chn2), and Chimerin3 (Chn3), which differ in their tissue distribution and subcellular localization.

Chimerin 1 is a protein that in humans is encoded by the CHN1 gene. It belongs to a family of proteins known as Rac GTPase-activating proteins (RacGAPs), which are involved in regulating various cellular processes such as cell growth, division, and movement. Chimerin 1 specifically inhibits the activity of Rac GTPases, which are important regulators of the actin cytoskeleton and play a role in various signaling pathways.

Chimerin 1 contains several functional domains, including a CH domain, a RhoGAP domain, and a coiled-coil domain. The CH domain binds to calcium/calmodulin, allowing Chimerin 1 to be activated by calcium signaling. The RhoGAP domain is responsible for the GTPase-activating activity of Chimerin 1, which promotes the hydrolysis of GTP to GDP and inactivates Rac GTPases. The coiled-coil domain mediates protein-protein interactions and may be involved in targeting Chimerin 1 to specific cellular locations.

Mutations in the CHN1 gene have been associated with certain neurological disorders, including spinocerebellar ataxia type 36 (SCA36) and hereditary spastic paraplegia type 58 (SPG58). These mutations may affect the function of Chimerin 1 and lead to abnormalities in neuronal development and maintenance.

Proto-oncogene proteins c-bcr are a group of intracellular signaling proteins that play a role in regulating cell growth, differentiation, and apoptosis (programmed cell death). They are encoded by the c-bcr gene located on chromosome 22. The c-bcr gene can fuse with the c-abl gene (located on chromosome 9) as a result of a chromosomal translocation, leading to the formation of the BCR-ABL fusion protein. This fusion protein has constitutively active tyrosine kinase activity and is associated with the development of certain types of leukemia, such as chronic myelogenous leukemia (CML).

The c-bcr gene can also fuse with other genes, leading to the formation of different fusion proteins that have been implicated in the development of other types of cancer. The normal function of c-bcr proteins is not fully understood, but they are thought to play a role in regulating the actin cytoskeleton and intracellular signaling pathways.

Ras GTPase-activating proteins (GAPs) are a group of regulatory proteins that play an essential role in the intracellular signaling pathways associated with cell growth, differentiation, and survival. They function as negative regulators of Ras small GTPases, which are crucial components of many signal transduction cascades.

Ras GTPases cycle between an active GTP-bound state and an inactive GDP-bound state. Ras GAPs enhance the intrinsic GTPase activity of Ras proteins, promoting the hydrolysis of GTP to GDP and thereby switching off the signal transduction pathway. This conversion from the active to the inactive form of Ras helps maintain proper cellular function and prevent uncontrolled cell growth, which can lead to diseases such as cancer.

There are several families of Ras GAPs, including p120GAP, neurofibromin (NF1), and IQGAPs, among others. Each family has distinct structural features and functions, but they all share the ability to stimulate the GTPase activity of Ras proteins. Dysregulation or mutations in Ras GAPs can result in aberrant Ras signaling, contributing to various pathological conditions, including cancer and developmental disorders.

Human chromosome pair 2 consists of two rod-shaped structures present in the nucleus of each cell of the human body. Each member of the pair contains thousands of genes and other genetic material, encoded in the form of DNA molecules. Chromosomes are the physical carriers of inheritance, and human cells typically contain 23 pairs of chromosomes for a total of 46 chromosomes.

Chromosome pair 2 is one of the autosomal pairs, meaning that it is not a sex chromosome (X or Y). Each member of chromosome pair 2 is approximately 247 million base pairs in length and contains an estimated 1,000-1,300 genes. These genes play crucial roles in various biological processes, including development, metabolism, and response to environmental stimuli.

Abnormalities in chromosome pair 2 can lead to genetic disorders, such as cat-eye syndrome (CES), which is characterized by iris abnormalities, anal atresia, hearing loss, and intellectual disability. This disorder arises from the presence of an extra copy of a small region on chromosome 2, resulting in partial trisomy of this region. Other genetic conditions associated with chromosome pair 2 include proximal 2q13.3 microdeletion syndrome and Potocki-Lupski syndrome (PTLS).

Spermatocytes are a type of cell that is involved in the process of spermatogenesis, which is the formation of sperm in the testes. Specifically, spermatocytes are the cells that undergo meiosis, a special type of cell division that results in the production of four haploid daughter cells, each containing half the number of chromosomes as the parent cell.

There are two types of spermatocytes: primary and secondary. Primary spermatocytes are diploid cells that contain 46 chromosomes (23 pairs). During meiosis I, these cells undergo a process called crossing over, in which genetic material is exchanged between homologous chromosomes. After crossing over, the primary spermatocytes divide into two secondary spermatocytes, each containing 23 chromosomes (but still with 23 pairs).

Secondary spermatocytes then undergo meiosis II, which results in the formation of four haploid spermatids. Each spermatid contains 23 single chromosomes and will eventually develop into a mature sperm cell through a process called spermiogenesis.

It's worth noting that spermatocytes are only found in males, as they are specific to the male reproductive system.

Rac (Ras-related C3 botulinum toxin substrate) GTP-binding proteins are a subfamily of the Rho family of small GTPases, which function as molecular switches that regulate various cellular processes, including actin cytoskeleton organization, cell adhesion, and gene transcription.

Rac GTP-binding proteins cycle between an inactive GDP-bound state and an active GTP-bound state. When Rac is in its active state, it interacts with downstream effectors to regulate various signaling pathways that control cell behavior. Activation of Rac promotes the formation of lamellipodia and membrane ruffles, which are important for cell migration and invasion.

Rac GTP-binding proteins have been implicated in a variety of physiological and pathological processes, including embryonic development, immune function, and cancer. Dysregulation of Rac signaling has been associated with various diseases, such as inflammatory disorders, neurological disorders, and cancer. Therefore, understanding the regulation and function of Rac GTP-binding proteins is crucial for developing therapeutic strategies to target these diseases.

... 1 Chimerin 2 There are four known isoforms of the chimerin protein. These include α1, α2, β1, and β2. α1-Chimerin was ... Chimerin is a type of nerve tissue protein. Chimerins are a family of non-protein kinase C phorbol ester receptors. They were ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... Mutations found in α-chi-merin lead to the Duane retraction syndrome 2. Beta-chimerin (Rho GTPase-activating protein 3, 468aa) ...
1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". ... Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein ... MYO9B is a gene that encodes the Myosin-IXb protein. GRCh38: Ensembl release 89: ENSG00000099331 - Ensembl, May 2017 GRCm38: ...
... (CHN1), also known as alpha-1-chimerin, n-chimerin, is a protein which in humans is encoded by the CHN1 gene. ... Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may ... "Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and ... GTP-binding protein regulators, Proteins, All stub articles, Human chromosome 2 gene stubs). ...
... (beta-chimaerin) is a protein that in humans is encoded by the CHN2 gene. This gene is a member of the chimerin ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ... This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol ( ... DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the ...
... chimerin 1 MeSH D12.776.402.150.500.460 - neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
Agrin Chimerin Proteins Chromogranins Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 ... Neuronal Apoptosis-Inhibitory Protein Neuronal Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein S100 Proteins ... Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), ... Protein Glucose Transporter Type 3 Hu Paraneoplastic Encephalomyelitis Antigens Microtubule-Associated Proteins Myelin Proteins ...
... cdc2 protein kinase MeSH D12.776.476.325.150.100 - chimerin proteins MeSH D12.776.476.325.150.100.200 - chimerin 1 MeSH D12.776 ... smad1 protein MeSH D12.776.476.024.417.500.200 - smad2 protein MeSH D12.776.476.024.417.500.300 - smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.476.024.417.249.600 - smad6 protein MeSH D12.776.476.024.417.249.700 - smad7 protein ... rhoa gtp-binding protein MeSH D12.776.476.525.700.300 - rhob gtp-binding protein The list continues at List of MeSH codes ( ...
... gtpase-activating proteins MeSH D12.644.360.325.150.100 - chimerin proteins MeSH D12.644.360.325.150.100.200 - chimerin 1 MeSH ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... wnt proteins MeSH D12.644.276.996.500 - wnt1 protein MeSH D12.644.276.996.750 - wnt2 protein MeSH D12.644.360.011 - activating ...
The CHN1 gene provides instructions for making two very similar proteins called α1-chimaerin and α2-chimaerin. Learn about this ... Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing ... The CHN1 gene provides instructions for making two very similar proteins called α1-chimaerin and α2-chimaerin. These proteins ... The CHN1 proteins, particularly α2-chimaerin, appear to be critical for the formation of certain nerves in the head and face. ...
Chimerin 1 Chimerin 2 There are four known isoforms of the chimerin protein. These include α1, α2, β1, and β2. α1-Chimerin was ... Chimerin is a type of nerve tissue protein. Chimerins are a family of non-protein kinase C phorbol ester receptors. They were ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... Mutations found in α-chi-merin lead to the Duane retraction syndrome 2. Beta-chimerin (Rho GTPase-activating protein 3, 468aa) ...
GTP-binding protein regulators. GTPase activating protein. Chimerin 1 - RasGAP (Neurofibromin 1, IQ motif containing GTPase ... Categories: Genes on chromosome 2 , Genes on chromosome 14 , GTP-Binding Protein Regulators , Proteins ... Ras-GTPases act as molecular switches that bind to downstream effectors, such as the protein kinase c-Raf, and localizes them ... The normal rate of Ras catalytic GTPase (GTP hydrolysis) activity can be increased by proteins of the RasGAP family, which bind ...
Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with ... coding for chimerin 1), Rgs17 (encoding regulator of G protein signaling 17), Syn2 (producing synapsin 2), Celf2 (coding for ... transmembrane protein 50B protein), Tmem176b (encoding transmembrane protein 176B), Pdcl3 (coding for phosducin-like protein 3 ... In GABA+/Crh+ neurons, we observed a predominance of Prkacb (encoding c-AMP-dependent protein kinase subunit B), Amd2 (coding ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
CHIMERIN 1 QUIMERINA 1 QUIMERINA 1 CHIMERIN PROTEINS PROTEINAS QUIMERINAS PROTEÍNAS QUIMERINAS ... PROTEIN RENATURATION RENATURACION DE PROTEINA RENATURAÇÃO PROTÉICA PROTEIN STRUCTURE, QUATERNARY ESTRUCTURA CUATERNARIA DE ... SOS1 PROTEIN PROTEINA SOS1 PROTEÍNA SOS1 SPERM INJECTIONS, INTRACYTOPLASMIC INYECCIONES DE ESPERMA INTRACITOPLASMATICAS ... CDC42 GTP-BINDING PROTEIN, YEAST PROTEINA DE ENLACE-GTP CDC42 DE LEVADURA PROTEÍNA CDC42 DE LEVEDURA DE LIGAÇÃO A GTP ...
Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15). 3cxl. Crystal structure of human chimerin 1 (CHN1). ... are GTPase activating proteins (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases). A ... GAP proteins inactivate small Rho and Ras proteins, so inactivation of rhoGAP proteins might cause constitutive activation of ... Click on the protein counts, or double click on taxonomic names to display all proteins containing RhoGAP domain in the ...
Two key proteins necessary for successful cytokinesis have been localised to the central spindle: a kinesin-like protein (ZEN-4 ... 1A). The equivalent mutations eliminate in vitro GAP activity in α-chimerin GAP (Ahmed et al., 1994) and Cdc42GAP (Leonard et ... When the Pbl-interaction-domain deletion protein, TumΔPbl, is the only Tum protein present, cells proceed to a point in ... 5, Table 2). The mitotic localisation of the two proteins differed somewhat. TumΔEIE protein was not seen associated with ...
Description: Additional name(s) for this target protein: CHN2, Chimerin. Rat β chimaerin(CHN2) ELISA kit. ... Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological ... Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological ... Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review ...
Chimerin 1. A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain ... Molecular Motor Proteins. Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor) ... rhoA GTP-Binding Protein. A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly ... rho GTP-Binding Proteins. A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin ...
Chimerin 1 D12.776.641.124.200 D12.776.631.124.200 Chimerin Proteins D12.776.641.124 D12.776.631.124 Chive B1.650.940.800. ... ELAV Proteins D12.776.641.520 D12.776.631.520 ELAV-Like Protein 2 D12.776.641.520.500 D12.776.631.520.500 ELAV-Like Protein 3 ... PrP 27-30 Protein D12.776.785.700.700 D12.776.785.340.750.700 PrPC Proteins D12.776.785.680 D12.776.785.340.500 PrPSc Proteins ... Proto-Oncogene Proteins c-bcr D12.644.360.325.300.99.500 D12.776.476.325.300.99.500 Proto-Oncogene Proteins c-crk D12.644. ...
... the GTPase-activating protein a-chimerin can inhibit Rac1 down-stream of EphA4 in neurons, which could suppress dendritic ... The results obtained in slices were confirmed in vivo by chronic infusion of EphA4/Fc or ephrin Fc fusion proteins into the ... Chimeras are Fc fusion proteins in which the Fc portion of human immunoglobulin G1 is fused to the extracellular domain of ... Immunolabelling revealed a pronounced diffusion of the Fc proteins in the two lobules adjacent to the insertion site of the ...
... protein-protein interaction domain, and a C-terminal Psd-95, Dlg and ZO1 domain (PDZ)-binding motif (Pasquale, 2008). In its ... Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling ... axons with high levels of EphA proteins target regions with low levels of ephrin A proteins in the anterior-posterior axis, ... linked ephrin A proteins and EphB receptors bind to transmembrane ephrin B proteins. Some cross-reactivities have been reported ...
Click on the protein counts, or double click on taxonomic names to display all proteins containing C1 domain in the selected ... Crystal structure of human chimerin 1 (CHN1). 3ky9. Autoinhibited Vav1. 3pfq. Crystal Structure and Allosteric Activation of ... Intracellular protein phosphorylation by protein kinase C (PKC) plays a major role in the translation of extracellular signals ... Protein kinase C gamma type (P05129) (SMART). OMIM:176980: PROTEIN KINASE C, GAMMA; PRKCG. ...
centrosomal protein 192 [Sour.... CEP350. 9857. CEP350. centrosomal protein 350 [Sour.... CHN2. 1124. CHN2. chimerin 2 [Source: ...
Chimerin Proteins [D12.776.631.124] * Chromogranins [D12.776.631.199] * Disks Large Homolog 4 Protein [D12.776.631.224] ... Amino Acids, Peptides, and Proteins [D12] * Proteins [D12.776] * Nerve Tissue Proteins [D12.776.631] * Acid Sensing Ion ... A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been ... A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been ...
For G607S, DINE mRNA and protein expression was decreased or almost absent in motor neurons. In the C760R mutant mice DINE was ... Intriguingly, distinct phenotypes in DINE protein localization and mRNA expression were identified in these knock-in mouse ... reported that knock-in mice with an α2-chimerin gain-of-function missense mutation, identified in CCDD patients, showed a ... The homologous residue in a family member protein to cysteine 760 in the DINE protein has been shown to form a disulfide bond [ ...
RefSeq Protein NP_001157112 NP_076032 RefSeq DNA NM_001163640. NM_023543 Description chimerin (chimaerin) 2. ... RefSeq Protein None RefSeq DNA NM_029638. NM_001161621. NM_001161622 Description amiloride binding protein 1 (amine oxidase, ... RefSeq Protein XP_900161 RefSeq DNA XM_895068 Description ganglioside-induced differentiation-associated-protein 10. ... RefSeq Protein None RefSeq DNA NM_013871 Description mitogen-activated protein kinase 12. ...
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, ... All these proteins can bind adaptor proteins through SH2, SH3 or proline rich domains to recruit actin binding proteins ( ... Activated RhoA is able to inhibit Rac-1 through the ARHGAP2 (also named chimerin-2), while Rac1 activates WAVE2 which in turn ... NEDD9 as an adaptor protein of the p130Cas family binding DOCK3, and WAVE2 as a protein that promotes actin nucleation ...
... a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of ... keywords = "Abducens Nerve, Amino Acid Sequence, Animals, Axons, Cell Line, Cell Membrane, Chick Embryo, Chimerin 1, Duane ... a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of ... a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of ...
  • They are represented as a family of four closely bound GAPs1 (GTPase-activating proteins). (wikipedia.org)
  • α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. (wikipedia.org)
  • Beta-chimerin (Rho GTPase-activating protein 3, 468aa) is mainly found in the brain and pancreas and the expression is in the form of reduced malignant gliomas. (wikipedia.org)
  • It is also an SH2 containing GTPase activating protein and bears many similarities in function. (wikipedia.org)
  • The normal rate of Ras catalytic GTPase (GTP hydrolysis) activity can be increased by proteins of the RasGAP family, which bind to Ras and increase its catalytic rate by a factor of one thousand - in effect, increasing the rate at which Ras is inactivated. (bionity.com)
  • This may be explained because the SOS1 protein adopts an auto-inhibited conformation dependent on multiple domain-to-domain interactions that cooperate to block access of the SOS1 catalytic core to its Ras-GTPase targets [7] . (bionity.com)
  • GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. (embl.de)
  • The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. (embl.de)
  • This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl.de)
  • By enhancing their GTPase activity, GAP proteins inactivate small Rho and Ras proteins, so inactivation of rhoGAP proteins might cause constitutive activation of their GTPase targets. (embl.de)
  • A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
  • Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)
  • Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)
  • Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
  • Mutations in α2-chimerin can cause disorders such as Duane Retraction Syndrome as it changes the signals on how the eye moves. (wikipedia.org)
  • The CHN1 gene provides instructions for making two very similar proteins called α1-chimaerin and α2-chimaerin. (medlineplus.gov)
  • The CHN1 proteins, particularly α2-chimaerin, appear to be critical for the formation of certain nerves in the head and face. (medlineplus.gov)
  • Researchers believe that the features of this condition result from changes in one of the two versions of the CHN1 protein, α2-chimaerin. (medlineplus.gov)
  • Studying families with a variant form of the disorder (DURS2-DRS), we have identified causative heterozygous missense mutations in CHN1, a gene on chromosome 2q31 that encodes alpha2-chimaerin, a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of corticospinal axons in mice. (elsevierpure.com)
  • Chimerins are a family of non-protein kinase C phorbol ester receptors. (wikipedia.org)
  • These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl-heidelberg.de)
  • Ras-GTPases act as molecular switches that bind to downstream effectors, such as the protein kinase c-Raf , and localizes them to the membrane resulting in their activation. (bionity.com)
  • Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. (embl.de)
  • Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
  • In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
  • FN2 is followed by a transmembrane (TM) helix, and an intracellular part consisting of a juxtamembrane (JM) region with several conserved tyrosine (Y) residues, a tyrosine kinase domain, a sterile-α motif (SAM) protein-protein interaction domain, and a C-terminal Psd-95, Dlg and ZO1 domain (PDZ)-binding motif ( Pasquale, 2008 ). (silverchair.com)
  • Taxonomy and function of C1 protein kinase C homology domains. (embl-heidelberg.de)
  • NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. (embl-heidelberg.de)
  • Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme. (embl-heidelberg.de)
  • A-kinase anchoring protein 10. (gsea-msigdb.org)
  • A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). (bvsalud.org)
  • They exclusively bind membrane-tethered ligands known as ephrin proteins. (silverchair.com)
  • Typically, EphA receptors bind to glycosylphosphatidylinositol anchor (GPI)-linked ephrin A proteins and EphB receptors bind to transmembrane ephrin B proteins. (silverchair.com)
  • Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl-heidelberg.de)
  • All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)
  • α1-Chimerin is also able to regulate dendritic spinal density by binding to NMDA receptors at the NR2A subunit. (wikipedia.org)
  • Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl.de)
  • β2-Chimerin can be linked to a fusion gene that is associated with a key insulin receptor that causes people to have decreased levels of insulin. (wikipedia.org)
  • Eph and ephrin proteins interact with a number of other ligand/receptor systems to influence how cells translate environmental signals to orchestrate morphogenetic events. (silverchair.com)
  • juega un papel crítico en la PLASTICIDAD SINÁPTICA mediada por el receptor NMDA. (bvsalud.org)
  • Residues conserved across the rhoGAP family are largely confined to one face of this bundle, which may be an interaction site for target G proteins. (embl.de)
  • The observed behavior indicates conformational exchange between bound and free states upon protein-micelle interaction. (embl-heidelberg.de)
  • These proteins help guide the growth of axons and dendrites, which are specialized extensions of neurons that transmit and receive nerve impulses throughout the nervous system. (medlineplus.gov)
  • Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (embl.de)
  • There are 47093 RhoGAP domains in 46979 proteins in SMART's nrdb database. (embl.de)
  • Rho-specific GAP domains are found in a wide variety of large, multi-functional proteins. (embl.de)
  • There are 58922 C1 domains in 42393 proteins in SMART's nrdb database. (embl-heidelberg.de)
  • We present a comprehensive list of 54 C1 domains occurring singly or doubly in 34 different proteins. (embl-heidelberg.de)
  • Proteins containing typical C1 domains are predicted to be regulated by diacylglycerol, whereas those containing only atypical domains are not. (embl-heidelberg.de)
  • Taxonomic distribution of proteins containing RhoGAP domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with RhoGAP domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing RhoGAP domain in the selected taxonomic class. (embl.de)
  • Taxonomic distribution of proteins containing C1 domain. (embl-heidelberg.de)
  • The complete taxonomic breakdown of all proteins with C1 domain is also avaliable . (embl-heidelberg.de)
  • A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling. (ouhsc.edu)
  • When introduced to the cancerous cells β2-chimerin then causes the G1 cell cycle to stop and therefore it stops the cells from multiplying. (wikipedia.org)
  • α2-Chimerin acts in a similar manner to α1-chimerin, but is primarily found in the brain and testes. (wikipedia.org)
  • Over expression of this protein in hippocampus tissue can inhibit the formation of new spines and remove existing spines. (wikipedia.org)
  • The retraction is dependent on the contractile protein thrombosthenin. (lookformedical.com)
  • A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. (nih.gov)
  • β2-Chimerin has been shown to play a role in breast cancer. (wikipedia.org)
  • These proteins play an important role in the early development of the nervous system. (medlineplus.gov)
  • The expression of α2-chimerin is present in development so α2-chimerin is essential for cognitive function as it directly leads to functioning cognitive ability in adulthood. (wikipedia.org)
  • Intriguingly, distinct phenotypes in DINE protein localization and mRNA expression were identified in these knock-in mouse lines. (biomedcentral.com)
  • For G607S, DINE mRNA and protein expression was decreased or almost absent in motor neurons. (biomedcentral.com)
  • α2-Chimerin was shown to be involved and important in cognitive development. (wikipedia.org)
  • α2-Chimerin also plays a role in the ocular motor system. (wikipedia.org)
  • α1-Chimerin was the first protein to be isolated from the brain. (wikipedia.org)
  • This is the product of an alternately spliced transcript of the human n-chimerin gene encoding an N-terminal SH2 (src homology 2) domain in addition to the phorbol ester receptor and GAP domains. (nih.gov)
  • β2-Chimerin can be linked to a fusion gene that is associated with a key insulin receptor that causes people to have decreased levels of insulin. (wikipedia.org)
  • The CHN1 gene provides instructions for making two very similar proteins called α1-chimaerin and α2-chimaerin. (medlineplus.gov)
  • β1-chimaerin belongs to the chimaerin family of GTPase-activating proteins (GAPs) and is encoded by the CHN2 gene, which also encodes the β2- and β3-chimaerin isoforms. (nih.gov)
  • From NCBI Gene: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. (nih.gov)
  • Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. (nih.gov)
  • The CHN1 proteins, particularly α2-chimaerin, appear to be critical for the formation of certain nerves in the head and face. (medlineplus.gov)
  • Researchers believe that the features of this condition result from changes in one of the two versions of the CHN1 protein, α2-chimaerin. (medlineplus.gov)
  • Each identified mutation changes a single protein building block (amino acid) in α2-chimaerin. (medlineplus.gov)
  • n-Chimerin (alpha 1-chimerin) is a brain GTPase-activating protein (GAP) for the ras-related p21rac. (nih.gov)
  • α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. (wikipedia.org)
  • α1-Chimerin is also able to regulate dendritic spinal density by binding to NMDA receptors at the NR2A subunit. (wikipedia.org)
  • A microtubule subunit protein found in large quantities in mammalian brain. (wakehealth.edu)
  • α2-Chimerin acts in a similar manner to α1-chimerin, but is primarily found in the brain and testes. (wikipedia.org)
  • These proteins play an important role in the early development of the nervous system. (medlineplus.gov)
  • These proteins help guide the growth of axons and dendrites, which are specialized extensions of neurons that transmit and receive nerve impulses throughout the nervous system. (medlineplus.gov)
  • The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases. (harvard.edu)
  • Chimerin+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Van de Ven TJ, VanDongen HM, VanDongen AM (October 2005). (wikipedia.org)
  • S100 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). (nih.gov)
  • secretory carrier membrane protein 4 [So. (gsea-msigdb.org)
  • They are represented as a family of four closely bound GAPs1 (GTPase-activating proteins). (wikipedia.org)
  • A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. (harvard.edu)
  • heat shock protein family D (Hsp60) memb. (gsea-msigdb.org)
  • We now report the occurrence of another form of chimerin, termed alpha 2-chimerin. (nih.gov)
  • alpha 1- and alpha 2-chimerin mRNAs were expressed differently. (nih.gov)
  • In the rat brain, only alpha 1-chimerin mRNA was expressed in cerebellar Purkinje cells, although both alpha 1- and alpha 2-chimerin mRNAs occurred in neurons in the cerebral cortex, hippocampus, and thalamus. (nih.gov)
  • GTP-Binding Proteins, in the D tree, were expanded with the addition of 16 specific proteins and many associated enzymes along with the rearrangement of closely related concepts. (nih.gov)
  • α2-Chimerin was shown to be involved and important in cognitive development. (wikipedia.org)
  • This graph shows the total number of publications written about "S100 Proteins" by people in Harvard Catalyst Profiles by year, and whether "S100 Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "S100 Proteins" by people in Profiles. (harvard.edu)