A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.
A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.
Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.
A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Databases devoted to knowledge about specific genes and gene products.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies produced by a single clone of cells.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The study of the structure, growth, activities, and functions of NEURONS and the NERVOUS SYSTEM.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Organized activities related to the storage, location, search, and retrieval of information.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.
Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.
An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
The morning glory family of flowering plants, of the order Solanales, which includes about 50 genera and at least 1,400 species. Leaves are alternate and flowers are funnel-shaped. Most are twining and erect herbs, with a few woody vines, trees, and shrubs.
A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
The systematic study of the complete DNA sequences (GENOME) of organisms.

Molecular heterogeneity and function of EWS-WT1 fusion transcripts in desmoplastic small round cell tumors. (1/21)

Desmoplastic small round cell tumor (DSRCT) is a primitive sarcoma with a consistent cytogenetic abnormality, t(11;22)(p13;q12). This chromosomal translocation generates a chimeric transcript that is formed by fusion of the 5' region of the Ewing's sarcoma gene, EWS, with the 3' DNA-binding segment of WT1, the Wilms' tumor suppressor gene. We collected 14 DSRCT tumor samples and examined the hybrid transcripts. We identified: (a) combinatorial heterogeneity of EWS exons fused to WT1 including use of EWS exons 7, 8, and 9; (b) subpopulations of variant transcripts in 6 of 14 tumors characterized by aberrant splicing resulting in loss of EWS exon 6 or WT1 exon 9; (c) multiple cDNA products with large internal deletions; and (d) insertion of small stretches of heterologous DNA at the fusion site or exon splice region in transcripts from two tumors. Most of the splice variants were in-frame, and in vitro translated fusion proteins with intact DNA-binding motifs formed complexes with a WT1 response element in gel mobility assays. Each of the chimeric proteins retains the ability to bind to the GC and TC elements of the early transcription factor EGR-1 as well as WT1 consensus sequences. We present evidence that various EWS-WT1 proteins up-regulated EGR-1 promoter activity and that this up-regulation is specifically dependent upon the absence of the exon 9 KTS domain of WT1. The molecular diversity and functionality exhibited by these fusion transcripts may have significant biological implications for their transactivating and tumorigenic potential.  (+info)

Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. (2/21)

In patients with localized prostate cancer, radical prostatectomy and radiation therapy, although effective in controlling localized disease, are often associated with significant side effects attributable to injury of adjacent tissues. Moreover, patients with metastatic disease eventually fail systemic hormonal or chemotherapy because of the development of progressive, refractory disease. In this study, we evaluated the safety and efficacy of a novel suicide gene therapy that could potentially spare normal tissue while bypassing molecular mechanisms of apoptosis resistance by using chemically inducible effector caspases to trigger apoptosis in prostate cancer cells. Initially, we compared the ability of a panel of inducible Fas signaling intermediates to kill human and murine prostate cancer cell lines. On the basis of the superior killing by downstream caspase-1 and caspase-3, replication-deficient adenoviral vectors expressing conditional caspase-1 (Ad-G/iCasp1) or caspase-3 (Ad-G/iCasp3), regulated by nontoxic, lipid-permeable, chemical inducers of dimerization (CID), were constructed. Upon vector transduction followed by CID administration, aggregation and activation of these recombinant caspases occur, leading to rapid apoptosis. In vitro, both human (LNCaP and PC-3) and murine (TRAMP-C2 and TRAMP-C2G) prostate cancer cell lines were efficiently transduced and killed in a CID-dependent fashion. In vivo, direct injection of Ad-G/iCasp1 into s.c. TRAMP-C2 tumors caused focal but extensive apoptosis without evidence for a bystander effect at the maximal viral dose (i.e., 2.5 x 10(10) viral particles/25 microl) in host animals that also received CID compared with control animals. Treatment with Ad-G/iCasp1 plus CID resulted in a transient, yet significant, reduction both in tumor growth and volume compared with tumors treated with vector but not CID (P < 0.035) or vector-diluent plus CID (P < 0.022), both of which grew more rapidly. These results demonstrate that CID-regulated, caspase-based suicide gene therapy is safe and can inhibit the growth of experimental prostate cancer in vitro and in vivo through potent induction of apoptosis, providing a rationale for further development.  (+info)

Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. (3/21)

The regulation and function of chimaerins, a family of "non-protein kinase C" (PKC) phorbol ester/diacylglycerol receptors with Rac-GAP activity, is largely unknown. In a search for chimaerin-interacting proteins, we isolated Tmp21-I (p23), a protein localized at the perinuclear Golgi area. Remarkably, phorbol esters translocate beta2-chimaerin to the perinuclear region and promote its association with Tmp21-I in a PKC-independent manner. A deletional analysis revealed that the C1 domain in chimaerins is required for the interaction with Tmp21-I, thereby implying a novel function for this domain in protein-protein associations in addition to its role in lipid and phorbol ester binding. Our results support the emerging concept that multiple pathways transduce signaling by phorbol esters and revealed that, like PKC isozymes, chimaerins are subject to a positional regulation. In this setting, Tmp21-I serves as an anchoring protein that determines the intracellular localization of these novel phorbol ester receptors.  (+info)

A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis. (4/21)

Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We constructed a chimeric receptor (VEGFR2Fas) combining the extracellular and transmembrane domains of VEGFR-2 with the cytoplasmic domain of Fas receptor. When VEGFR2Fas was stably expressed in endothelial cells in vitro, treatment with VEGF rapidly induced cell death with features characteristic of Fas-mediated apoptosis. These findings demonstrate that VEGFR2Fas functions as a VEGF-triggered death receptor and raise the possibility that introduction of VEGFR2Fas into tumor endothelium or tumor cells in vivo may convert tumor-derived VEGF from an angiogenic factor into an antiangiogenesis agent.  (+info)

The exosome pathway in K562 cells is regulated by Rab11. (5/21)

During maturation, reticulocytes lose some membrane proteins that are not required on the mature red cell surface. The proteins are released into the extracellular medium associated with vesicles that are formed by budding of the endosomal membrane into the lumen of the compartment; this process results in the formation of multivesicular bodies (MVBs). Fusion of MVBs with the plasma membrane results in secretion of the small internal vesicles, termed exosomes. K562 cells release exosomes with similar characteristics to reticulocyte exosomes, in particular the transferrin receptor (TfR) is found associated with the vesicles. Interestingly, this cell line has been shown to possess high amounts of Rab11 compared with other Rab proteins. To assess the regulation of transferrin receptor release via exosome secretion by Rab11 in this cell type, K562 cells were stably transfected with GFP-Rab11wt or the GTP- and GDP-locked mutants. The distribution of the proteins was assessed by fluorescence microscopy. Transferrin recycling and the number of TfRs present on the surface of the transfected cells were reduced by overexpression of either Rab11wt or the mutants. The amount of released exosomes was analyzed by measuring different molecular markers present on these vesicles either biochemically or by western blot. Overexpression of the dominant-negative mutant Rab11S25N inhibited exosome release, whereas the secretion of exosomes was slightly stimulated in cells transfected with Rab11wt. Taken together, the results demonstrate that in K562 cells Rab11 modulates the exosome pathway although the exact step involved is still not known.  (+info)

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. (6/21)

Diacylglycerol is an essential second messenger in mammalian cells. The most prominent intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong to the protein kinase C (PKC) family. However, at least five alternative types of high-affinity diacylglycerol/phorbol-ester receptor are known: chimaerins, protein kinase D, RasGRPs, Munc13s and DAG kinase gamma. Recent evidence indicates that these have functional roles in diacylglycerol second messenger signalling in vivo and that several cellular processes depend on these targets rather than protein kinase C isozymes. These findings contradict the still prevalent view according to which all diacylglycerol/phorbol-ester effects are caused by the activation of protein kinase C isozymes. RasGRP1 (in Ras/Raf/MEK/ERK signalling) and Munc13-1 (in neurotransmitter secretion) are examples of non-PKC diacylglycerol/phorbol-ester receptors that mediate diacylglycerol and phorbol-ester effects originally thought to be caused by PKC isozymes. In the future, pharmacological studies on PKC must be complemented with alternative experimental approaches to allow the separation of PKC-mediated effects from those caused by alternative targets of the diacylglycerol second messenger pathway. The examples of RasGRP1 and Munc13-1 show that detailed genetic analyses of C(1)-domain-containing non-PKC diacylglycerol/phorbol-ester receptors in mammals are ideally suited to achieve this goal.  (+info)

Enhancing major histocompatibility complex class I antigen presentation by targeting antigen to centrosomes. (7/21)

Several strategies that increase proteasomal degradation of antigen have been shown to improve MHC class I presentation of antigen. Because recent studies have demonstrated that the centrosome is a subcellular compartment rich in proteasomes, we hypothesized that targeting a tumor antigen to centrosomal compartments would enhance both the MHC class I presentation of antigen and the vaccine potency. We, therefore, created a chimera of gamma-tubulin, an established centrosomal marker, with a model tumor antigen, human papillomavirus type 16 (HPV-16) E7, in a DNA vaccine. The linkage of gamma-tubulin to E7-targeted antigen to centrosomal compartments, resulted in enhanced MHC class I presentation of E7, and led to a marked increase in the number of E7-specific CD8(+) T-cell precursors as well as a potent CD4-independent antitumor effect against an E7-expressing tumor cell line, TC-1. In addition, vaccination with gamma-tubulin/E7 DNA in transporter associated with antigen presentation (TAP)-1-knockout mice revealed that the enhancement of E7-specific CD8(+) T-cell immune responses is TAP-1-dependent. Our data suggest that the centrosome may be an important locus for MHC class I antigen processing and that targeting antigen to the centrosome can improve DNA vaccine potency.  (+info)

Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications. (8/21)

Phorbol esters, natural compounds that mimic the action of the lipid second messenger diacylglycerol (DAG), are known to exert their biological actions through the activation of classical and novel protein kinase C (PKC) isozymes. Phorbol esters, via binding to the PKC C1 domains, cause major effects on mitogenesis by controlling the activity of cyclin-cdk complexes and the expression of cdk inhibitors. In the last years it became clear that phorbol esters activate other molecules having a C1 domain in addition to PKCs. One of the most interesting families of "non-kinase" phorbol ester receptors is represented by the chimaerins, lipid-regulated Rac-GAPs that modulate actin cytoskeleton reorganization, migration, and proliferation. The discovery of the chimaerins and other "non-kinase" phorbol ester receptors has major implications in the design of agents for cancer therapy.  (+info)

Roncoroni, A.J.; de Cortigianni, M.R.; García Damiano, M.C., 1989: Cost and effectiveness of fecal culture in the etiologic diagnosis of acute diarrhea
sample_1: CssA4 (36mer)0.4 1.1 mM; CssA4 (36mer), 13C/15N-uniformly labeled, 0.4 1.1 mM; CssA4 (36mer), 13C/15N-AU labeled, 0.4 1.1 mM; CssA4 (36mer), partially deuterated, 0.4 1.1 mM; H2O 95%; D2O 5%. sample_conditions_1: pH: 6.0; pressure: 1 atm; temperature: 280 K. sample_conditions_2: pH: 6.0; pressure: 1 atm; temperature: 298 K ...
In our globalized world, infection research is becoming ever more important. Thanks to long-distance travel and global exchange of goods, bacteria and viruses can spread very rapidly. Only by learning how these pathogens function will we be able to effectively protect ourselves against them.. Thats the approach pursued by CSSB, where biologists, chemists, medical scientists, physicists and engineers join forces to investigate the interaction of pathogens with their hosts. DESY offers them unique facilities in Germany that provide optimal conditions for structural biology. Using super microscopes such as PETRA III, FLASH and European XFEL, reseachers are able to study biological samples in different ways - ranging from structural analysis of single molecules to real-time imaging of processes in living cells - and thus explore the molecular basis of diseases with extremely high spatial and temporal resolution.. ...
In our globalized world, infection research is becoming ever more important. Thanks to long-distance travel and global exchange of goods, bacteria and viruses can spread very rapidly. Only by learning how these pathogens function will we be able to effectively protect ourselves against them.. Thats the approach pursued by CSSB, where biologists, chemists, medical scientists, physicists and engineers join forces to investigate the interaction of pathogens with their hosts. DESY offers them unique facilities in Germany that provide optimal conditions for structural biology. Using super microscopes such as PETRA III, FLASH and European XFEL, reseachers are able to study biological samples in different ways - ranging from structural analysis of single molecules to real-time imaging of processes in living cells - and thus explore the molecular basis of diseases with extremely high spatial and temporal resolution.. ...
Most of the studies on cell proliferation examine the control of gene expression by specific transcription factors that act on transcriptional initiation. In the last few years, it became evident that mRNA stability/turnover provides an important mechanism for post-transcriptional control of gene expression. In eukaryotes, mRNAs are mainly degraded after deadenylation by decapping and exosome pathways. Mechanisms of mRNA surveillance comprise deadenylation-independent pathways such as NMD (nonsense-mediated decay), when mRNAs harbour a PTC (premature termination codon), NSD (non-stop decay, when mRNAs lack a termination codon, and NGD (no-go decay), when mRNA translation elongation stalls. Many proteins involved in these processes are conserved from bacteria to yeast and humans. Recent papers showed the involvement of proteins deputed to decapping in controlling cell proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field. ...
Our methods of integrating different structural biology approaches and putting molecular complexes into a cellular context can certainly be applied to almost any field, including the field of infection biology. On the systems level, interesting research is also conducted. For example, Jörg Vogel, the director of the Institute for Molecular Infection Biology at University of Würzburg, who will also be talking at the symposium, is investigating the cellular response to bacterial infection and determining how gene expression is changed upon infection. I am looking forward to hearing him speak and to learning more about the different areas in infection biology that require structural biology approaches ...
Complete information for CHN2 gene (Protein Coding), Chimerin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
You may search for particular presentations by typing key words, an authors name, or the title in the box below. To narrow your search results, prefix your search terms with the day of the week (e.g. Tuesday Corn) ...
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Levitra blurred vision - Ebv can also result from a provider with hiv infection, hiv nucleic acid in solution. J am acad child adolesc psychopharmacol. It is suggested otherwise, a hard cervical collar. B. Thiazidesthiazides are distal to the rash.
Recombinant baculoviruses were isolated using the BaculoGold system (Pharmingen) as specified by the manufacturer. HEC-1-A, HeLa, and Vero cells were obtained from American Type Culture Collection (ATCC, Manassas, VA). (ii) pcDNA-MEF-gB, an expression plasmid for gB fused to an MEF tag (MEF-gB), was constructed by cloning a DNA fragment encoding MEF-gB amplified by PCR from recombinant virus DNA expressing MEF-gB (53) into pcDNA4/HisMax C (Invitrogen). To prevent bacterial superinfections, all SCID and RAG1−/−mice received prophylactic treatment of a Sulfatrim pediatric suspension (Barre-National, Baltimore, Md.) at the rate of 5 ml per 200 ml of drinking water. The cell pellets were subsequently lysed in 200 μl of radioimmunoprecipitation assay (RIPA) buffer (50 mM Tris-HCl [pH 8.0], 150 mM NaCl, 1.0% NP-40, 0.5% sodium deoxycholate, 2 mM EDTA, 1 mM Na3VO4, 1 mM phenylmethylsulfonyl fluoride, 1 mM DTT, 10 nM okadaic acid, and Complete protease inhibitor mix). Immunoblotting and ...
Beta-amyloid (Abeta) is a protein fragment created by the cutting of a larger protein, amyloid precursor protein (APP). Beta-amyloid is later secreted from nerve cells and into the fluid space surrounding them, where it aggregates into amyloid plaque, a characteristic feature of Alzheimer pathology. Complex cellular machinery and pathways perform the steps involved in secretion of beta-amyloid and other proteins. One such pathway results in the secretion of exosomes, tiny bubbles of cellular material released into the space outside the cell. Andrew F. Hill, Ph.D., and colleagues have recently shown that exosomes may contain (1) APP; (2) beta-amyloid, the final product of APP cleavage; and (3) an intermediate portion of APP known as the C-terminal fragment. They also found evidence that some of the cutting of APP to yield beta-amyloid occurs in the exosome.. Dr. Hill and colleagues plan to perform additional studies of the exosome pathway and its role in the processing and secretion of APP ...
Purpose: Myocilin has two distinct cellular distributions, cytoplasmic and membrane-associated, yet appears extracellularly. We have previously shown that myocilin is released from cells on exosomes, which are a component of the endosomal pathway. In this study we tested the hypothesis that myocilin enters the exosome pathway during plasma membrane receptor endocytosis.. Methods: Retinal pigment epithelia (RPE) in human eye-cups was stimulated with L-DOPA (1uM) to monitor endocytosis of GPR143 (OA1), an endogenous G-protein coupled receptor (GPCR) on the surface of RPE. Recombinant myocilin (WT, P370L and T377M) was heterologously co-expressed in transformed cells with GPR143 to test whether myocilin participates in receptor endocytosis and to determine the kinetics of binding. Cell surface proteins in eye-cups and transformed cells were biotinylated and protein trafficking and myocilin association were monitored over time using streptavidin beads. Finally, we tested myocilin binding to the ...
Diverse GTPase-activating proteins (GAPs) for the p21rho subfamily were detected by a novel overlay assay (Manser, E., Leung, T., Monfries, C., Teo, M., Hall, C., and Lim, L. (1992) J. Biol. Chem. 267, 16025-16028), with some GAPs being tissue-specific. Using a PCR strategy exploiting conserved regions common to rho/rac-GAPs, we have isolated a rat testis cDNA encoding a 34-kDa rac-GAP termed beta-chimaerin, as it was highly related to n-chimaerin, containing both a GAP domain (77% identity) and the phorbol ester-binding region (93% identity). beta-Chimaerin mRNA is expressed exclusively in the testis at the onset of sexual maturation. In situ hybridization and cell fractionation analyses show beta-chimaerin mRNA expression to be stage-specific, paralleling acrosomal assembly at the late stage of spermatogenesis. A corresponding testis-specific 30-kDa rac-GAP was detected. The testis-specific and stage-dependent expression of this new member of the chimaerin family offer an alternative model system for
Membership in the Churg Strauss Syndrome Association is free, although donations are always gratefully accepted. Completing the membership form will place you on the CSSA mailing list, a one way communication from the CSSA to members to inform people about updates to the website, news of upcoming conferences and any other news pertaining to CSS related matters.
Diseases of the central nervous system are relatively common in food animals. Potential causes include infectious agents, nutritional deficiencies, metabolic disorders, genetic defects, toxins, and idiopathic causes. Food animals are frequently raised in large groups, there is often human and animal traffic between groups, and large numbers of animals are often fed the same ration. This makes it important to obtain an accurate etiological diagnosis as soon as possible so that treatment can be initiated and to limit the spread of infectious agents and toxins. In all disease situations, an antemortem diagnosis is preferable to a postmortem one because it allows for possible treatment of affected individuals, but that is not always possible and determining the correct etiologic diagnosis often depends on a thorough postmortem examination and collection of samples. Critical components for obtaining a successful diagnosis are as complete a history as possible, a thorough examination of affected and ...
The CSSA is pleased to share two new patient stories by David Hohmann and Denise Trachsel. Both David and Denise are well known on the Churg Strauss message boards for their …
This mesmerizing soft pink rose quartz ball is seated delicately on top of a wooden stand. Rose Quartz is one of the most desirable of all quartz and is highly valued for the harmonious soft vibes it radiates; rose quartz is a powerful love energizer and is associated with love, romance, and relationships. The rose quartz spheres semi-translucent pink color and beautiful swirls makes it an excellent ornament for your home or office.. Rose Quartz Application and Symbolism in Feng Shui Also known as love stone, rose quartz are highly treasured for their soft harmonious vibes, and their use as a powerful love energizer. This rose quartz is a lovely gift because it is a strong symbol of love, and provides calm, delicate inspiration for its owner. The rose quartz is known to speed up processes of finding love, mend emotional wounds, strengthen relationships, and help with comprehension of love.. The rose quartzs delicate vibes make it a popular tool for emotional healing in meditation as well. ...
The etiologic diagnosis of Chagas disease has presented up to now a continuous and progressive development, with more and more precise, sensitive and practical procedures. Since when Carlos Chagas described Trypanosoma cruzi,and next its role as the agent of the disease he also discovered and carries his name, a large amount of research has been done with the purpose of ensuring its diagnosis.. In this meeting we will have the opportunity and the pleasure of hearing from experts, and changing experiences, on the present aspects of this diagnosis, either parasitological, biomolecular or serological. Complementing coordination on the parasitological diagnosis in this round-table, by Dr Alejandro Luquetti, I should like to introduce the presentation on serodiagnosis by Professor Eufrosina Setsu Umezawa, and following discussions, by summarizing the main aspects of the work on serodiagnosis which have been developed at the Instituto de Medicina Tropical de São Paulo.. Chagas disease serodiagnosis, ...
The death-associated protein kinase (DAPK) family has been characterized as a group of pro-apoptotic serine/threonine kinases that share specific structural features in their catalytic kinase domain. Two of the DAPK family members, DAPK1 and DAPK2, are calmodulin-dependent protein kinases that are regulated by oligomerization, calmodulin binding, and autophosphorylation. In this study, we have determined the crystal and solution structures of murine DAPK2 in the presence of the autoinhibitory domain, with and without bound nucleotides in the active site. The crystal structure shows dimers of DAPK2 in a conformation that is not permissible for protein substrate binding. Two different conformations were seen in the active site upon the introduction of nucleotide ligands. The monomeric and dimeric forms of DAPK2 were further analyzed for solution structure, and the results indicate that the dimers of DAPK2 are indeed formed through the association of two apposed catalytic domains, as seen in the ...
FAM226A (family with sequence similarity 226 member A (non-protein coding)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
β2-chimaerin is a Rac1-specific negative regulator and a candidate tumor suppressor in breast cancer but its precise function in mammary tumorigenesis in vivo is unknown. Here, we study for the first time the role of β2-chimaerin in breast cancer using a mouse model and describe an unforeseen role for this protein in epithelial cell-cell adhesion. We demonstrate that expression of β2-chimaerin in breast cancer epithelial cells reduces E-cadherin protein levels, thus loosening cell-cell contacts. In vivo, genetic ablation of β2-chimaerin in the MMTV-Neu/ErbB2 mice accelerates tumor onset, but delays tumor progression. Finally, analysis of clinical databases revealed an inverse correlation between β2-chimaerin and E-cadherin gene expressions in Her2+ breast tumors. Furthermore, breast cancer patients with low β2-chimaerin expression have reduced relapse free survival but develop metastasis at similar times. Overall, our data redefine the role of β2-chimaerin as tumor suppressor and provide ...
Living Mulch Builds Profits, Soil Living mulch functions like mulch on any farm or garden except - its alive. No, its not out of the latest horror movie; living mulch is a system farmers can use to benefit both profits and the soil. While the system has been around for a whil.... - American Society of Agronomy (ASA), Crop Science Society of America (CSSA), Soil Science Society of America (SSSA). Agronomy Journal, August 10, 2017. Embargo expired on 18-Oct-2017 at 09:00 ET ...
Given the forty year history of the program, the models in use have evolved over time and are captured in PANACHE under two broad categories. CURRENT MODELS describe models and flowcharts that are currently used in the program. LEGACY MODELS describe models that have been used previously in the ETSP but are presently not part of our core testing strategy. The overall intent is to provide accurate information on tests used for compounds in PANAChE, regardless of when that testing occurred ...
CS6 is a prevalent CF expressed by ETEC strains and is of special interest for a multivalent ETEC vaccine approach, as it is found globally in approximately 20% of clinically isolated ETEC strains (13, 22). CS6 is a polymeric structure consisting of two major structural subunits, CssA and CssB, with both having potential host intestinal binding activities (24, 25). Thus, the incorporation of both proteins into an adhesin-based ETEC vaccine may be required. Therefore, using various combinations and formulations of CssA and/or CssB, we aimed to maximize antigenicity, stability, and yield in order to identify an optimal composition for a CS6-derived vaccine candidate that could be incorporated into a multivalent subunit vaccine strategy targeting ETEC.. Adapting a similar donor strand complementation strategy that we used previously in designing a stable recombinant form of the ETEC CFA/I adhesin CfaE (27), we produced a panel of various in cis donor strand-complemented CS6 dimeric and trimeric ...
A) EBV infection makes the malarial parasite able to produce lymphoma. B) Malarias strain on the immune system makes EBV infection worse. C) Malaria occurs
A range of conditions see table . Due to uid inux into brain cells caused by cigar viagra either active contraction process must be aware that clindamycin resistance must exceed the risks. If mri is the request for organtissue donation has a history of fever history of. Recognition of sepsis in healthy children with inborn errors manifest themselves in one injury. We can affirm that fact that anxiety is panic attacks., a panic attack a discrete etiologic diagnosis. J osteopath med korr im.
MIR22HG (MIR22 host gene (non-protein coding) ) Blocking Peptide (the C terminal of MIR22HG)(100ug) - Read User Reviews, Features, Research Applications and get the Best Price/Quote
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For the first time, an entire publication has been dedicated to providing a critical review of the identification and analysis of the milk specific proteins
Desmoplastic small round cell tumour (DSRCT) is a rare sarcoma typically affecting young males and usually widely metastatic at presentation. Despite multimodal treatment approaches, the prognosis for DSRCT is extremely poor. Alkylator- and anthracyclines- based regimens are widely used as therapy and an initial response is common. Durable responses are exceptionally rare so further systemic treatment options for these patients represent an unmet medical need. We report two cases of metastatic, pretreated DSRCT patients achieving disease stabilisation with Trabectedin. Retrospective review of 2 patients with progressive DSRCT, treated with Trabectedin. Two males aged 19 and 23 years treated with Trabectedin, 1.5 mg/m2 over 24 hours 3 weekly for 6 and 5 cycles respectively. Best responses were stable disease in patient 1 and partial response (RECIST 1.1) in patient 2. Progression free survival was 4 months in both cases. Persistent neutropenia required 4 weekly administration in one patient but no other
I am not a medical or health professional. Information in this site has been gathered from numerous sources and is for research purposes only. I do not guarantee the accuracy of any information in this site. Desmoplastic Small Round Cell Tumor www.DSRCT.com ...
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I am a pediatric oncologist who specializes in the treatment of children and young adults with neuroblastoma and other solid tumors, such as desmoplastic small round cell tumors. These are challenging cancers to treat. By caring for patients and conducting research, I hope to be able make an impact and improve the lives of people diagnosed with these diseases.
Jays Tips. Peri-Colace seems to work better than Colace for constipation brought on by cancer medications. ww.dsrct.com desmoplastic small round cell tumor. ...
A Makahu father with a rare form of cancer is being denied a drug that may give him more time with his four young children. James Grieve, 44, was diagnosed with Desmoplastic Small Round Cell …
Expert Rev Allti Illfect Tiler. 98 -0. EBV can occa- sionally be transmitted through blood transfusion or bone marrow transplantation. 53 Belli P, Costantini M, Mirk P, et al.
This is a potent inhibitor of Group I PAK enzymes (PAK1, 2 and 3; PAK1 Ki = 4 nM) that has been screened versus 235 kinases at 100 nM, with biochemical inhibition of 5 kinases (IC50 ,50 nM) observed. Expanded off-target kinase screening would be helpful to enhance the selectivity profile. Parallel use of the orthogonal PAK1-selective probe NVS-PAK1-1 is suggested to aid interpretation of cellular effects between PAK family members. The selectivity of G-5555 for Group I PAK enzymes over non-kinase targets (IC50 ,10 uM for 36/42 diverse receptors, ion channels, enzymes and transporters) supports its use as a cellular probe. On-target activity in cells was demonstrated (inhibition of pMEK S298, IC50 = 69 nM) and supports the suggested concentration range for cellular studies. Compound pharmacokinetics are suitable for in vivo studies and on-target modulation of PAK-dependent pMEK S298 was demonstrated in H292 xenografts following 20 and 30 mg/kg single, oral doses. A caveat to the use of the ...
Desmoplastic small round cell tumor (DSRCT) is a rare, biologically aggressive soft tissue neoplasm of uncertain differentiation, most often arising in the abdominal and pelvic cavities of adolescents and young adults with a striking male predominance. Histologically, it is characterized by islands of uniform small round cells in prominent desmoplastic stroma, and it has a polyimmunophenotypic profile, typically expressing WT1 and cytokeratin, desmin, and neural/neuroendocrine differentiation markers to varying degrees. Tumors at other sites and with variant morphology are more rarely described. DSRCT is associated with a recurrent t(11;22)(p13;q12) translocation, leading to the characteristic EWSR1-WT1 gene fusion. Fluorescence in situ hybridization (FISH), to detect EWSR1 rearrangement, and reverse transcription-polymerase chain reaction (RT-PCR) to assess for EWSR1-WT1 fusion transcripts are routine diagnostic ancillary tools. We present a large institutional comparative series of FISH and ...
Patient, family, or caregivers personal pages, journals, experiences with Desmoplastic small round cell cancer. Also known as DSRCT, Desmoplastic sarcoma, Desmoplastic small round blue tumor
A rare, aggressive sarcoma that often develops in the abdominal cavity, although it can also arise elsewhere. The disease commonly affects adolescents and young adults, mostly male. Its name means that it is formed by small, round cancer cells surrounded by scar-like tissue.
Wang LL, Perlman EJ, Vujanic GM, Zuppan C, Brundler MA, Cheung CR, Calicchio ML, Dubois S, Cendron M, Murata-Collins JL, Wenger GD, Strzelecki D, Barr FG, Collins T, Perez-Atayde AR, Kozakewich H. Desmoplastic small round cell tumor of the kidney in childhood. Am J Surg Pathol. 2007 Apr; 31(4):576-84. View abstract ...
Objective. )e purpose of this study was to describe baseline data on etiological, clinical, laboratory, and management strategies in Kenyan children and adolescents with Disorders of Sex Development (DSD). Methods. )is retrospective study included patients diagnosed with DSD who presented at ages 0-19 years from January 2008 to December 2015 at the Kenyatta National (KNH) and Gertrudes Childrens (GCH) Hospitals. After conducting a search in the data registry, a structured data collection sheet was used for collection of demographic and clinical data. Data analysis involved description of the frequency of occurrence of various variables, such as etiologic diagnoses and patient characteristics. Results. Data from the records of 71 children and adolescents were reviewed at KNH (n � 57, 80.3%) and GCH (n � 14, 19.7%). )e mean age at the time of diagnosis was 2.7 years with a median of 3 months. )irty-nine (54.9%) children had karyotype testing done. )e median age (IQR) of children with ...
1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". ... Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein ... MYO9B is a gene that encodes the Myosin-IXb protein. GRCh38: Ensembl release 89: ENSG00000099331 - Ensembl, May 2017 GRCm38: ...
... chimerin 1 MeSH D12.776.402.150.500.460 - neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
... 1 Chimerin 2 Chimerin+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Van de Ven, ... There are four known isoforms of the Chimerin protein. These include α1, α2, β1, and β2. α1-Chimerin was the first protein to ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... "Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing ...
... , (CHN1) also known as alpha-1-chimerin, n-chimerin is a protein which in humans is encoded by the CHN1 gene. ... Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may ... "Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and ... CHN1 is a three-domain protein with the N-terminal SH2 domain, the C-terminal RhoGAP domain and the central C1 domain similar ...
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ... This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol ( ... DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the ...
Agrin Chimerin Proteins Chromogranins Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 ... Neuronal Apoptosis-Inhibitory Protein Neuronal Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein S100 Proteins ... Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), ... Protein Glucose Transporter Type 3 Hu Paraneoplastic Encephalomyelitis Antigens Microtubule-Associated Proteins Myelin Proteins ...
... cdc2 protein kinase MeSH D12.776.476.325.150.100 - chimerin proteins MeSH D12.776.476.325.150.100.200 - chimerin 1 MeSH D12.776 ... smad1 protein MeSH D12.776.476.024.417.500.200 - smad2 protein MeSH D12.776.476.024.417.500.300 - smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.476.024.417.249.600 - smad6 protein MeSH D12.776.476.024.417.249.700 - smad7 protein ... rhoa gtp-binding protein MeSH D12.776.476.525.700.300 - rhob gtp-binding protein The list continues at List of MeSH codes ( ...
... regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ... GTP-Binding+Protein+Regulators at the US National Library of Medicine Medical Subject Headings (MeSH) ... The inactive form of GTPases (GDP-form) are activated by a class of proteins called Guanosine nucleotide exchange factors (GEFs ...
Growth Associated Protein 43 also known as GAP43 is a protein that in humans is encoded by the GAP43 gene.[5] ... neuron growth-associated protein 43. Function[edit]. GAP43, is a nervous tissue-specific cytoplasmic protein that can be ... protein kinase C-activating G-protein coupled receptor signaling pathway. • response to wounding. • regulation of growth. • ... protein-protein interaction and structural remodeling via actin polymerization.. Clinical significance[edit]. Humans with a ...
... gtpase-activating proteins MeSH D12.644.360.325.150.100 - chimerin proteins MeSH D12.644.360.325.150.100.200 - chimerin 1 MeSH ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... wnt proteins MeSH D12.644.276.996.500 - wnt1 protein MeSH D12.644.276.996.750 - wnt2 protein MeSH D12.644.360.011 - activating ...
The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf.[7] Raf in turn activates ... positive regulation of Ras protein signal transduction. • transmembrane receptor protein tyrosine kinase signaling pathway. • ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... The term nerve growth factor usually refers to the 2.5S, 26-kDa beta subunit of the protein, the only component of the 7S NGF ...
Parathyroid hormone-related protein. *Peroxisome proliferator-activated receptor gamma. *Pleiotrophin. *RAB7A. *RET proto- ... Chimerin 2. *Α-シヌクレイン. *CD4. Metadata. This file contains additional information, probably added from the digital camera or ...
"Chimerin Proteins" by people in UAMS Profiles by year, and whether "Chimerin Proteins" was a major or minor topic of these ... "Chimerin Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Chimerin Proteins" by people in Profiles over the past ten years. ... Below are MeSH descriptors whose meaning is more general than "Chimerin Proteins". ...
Protein Coding), Chimerin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... Protein Symbol:. P52757-CHIO_HUMAN. Recommended name:. Beta-chimaerin Protein Accession:. P52757. Secondary Accessions: *A4D1A2 ... CHN2 (Chimerin 2) is a Protein Coding gene. Diseases associated with CHN2 include Hepatosplenic T-Cell Lymphoma and Background ... chimerin beta-2,GTPase activating protein for the ras-related p21rac,DAG (diacylglycerol) receptor,expressed in cerebellum, ...
The CHN1 gene provides instructions for making two very similar proteins called α1-chimaerin and α2-chimaerin. Learn about this ... Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing ... The CHN1 gene provides instructions for making two very similar proteins called α1-chimaerin and α2-chimaerin. These proteins ... The CHN1 proteins, particularly α2-chimaerin, appear to be critical for the formation of certain nerves in the head and face. ...
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity ... The Gene Wiki collection of pages on human genes and proteins. More...GeneWikii. Chimerin_2. ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF00130 C1_1, 1 hit. PF00620 RhoGAP, 1 hit. PF00017 SH2, 1 ...
Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) CHN2 ARHGAP3, BCH ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS50238, RHOGAP, 1 hit. PS00479, ZF ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR020454, ...
Chimerin 1 Chimerin 2 Chimerin+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Van de Ven, ... There are four known isoforms of the Chimerin protein. These include α1, α2, β1, and β2. α1-Chimerin was the first protein to ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... "Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing ...
... alpha3-chimerin; chimaerin; chimaerin 1; chimerin (chimaerin) 1; N-chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2 ... Protein Aliases: A-chimaerin; a2-chimaerin; Alpha-chimerin; alpha1 chimaerin; alpha2 chimaerin; ... SH3/SH2 adaptor activity GTPase activator activity protein binding metal ion binding ephrin receptor binding phorbol ester ... GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as ...
Chimerin Proteins/genetics*; Chimerin Proteins/metabolism*; Chlorocebus aethiops; Diglycerides/metabolism; Exons/genetics; Gene ... Protein Isoforms/metabolism; RNA, Small Interfering; Sequence Deletion; rac1 GTP-Binding Protein/genetics; rac1 GTP-Binding ... Abstract: β1-chimaerin belongs to the chimaerin family of GTPase-activating proteins (GAPs) and is encoded by the CHN2 gene, ...
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ... This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol ( ... DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the ...
The Chimaerin gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, an SH2 ... This protein has GTPase-activating protein activity which is regulated by phospholipid binding and binding of diacylglycerol ( ... DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ...
1996) Human myosin IX-b. An unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J ... 1997) Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc Natl Acad Sci USA 94:9956- ... Myr 8 antibody-Protein G Sepharose. Two milligrams of affinity-purified myr 8b antibodies were coupled to Protein G Sepharose 4 ... 1988) The Drosophila ninaC locus encodes two photoreceptor cell-specific proteins with domains homologous to protein kinases ...
Caltag Medsystems supply a wide range of fusion proteins for cancer research, neurobiology, metabolism, apoptosis, cell biology ... Fusion Protein (10ug). FP-0007. Signosis. Enquire. order. Beta-chimaerin (Beta-chimerin) (SH2-Domain - CHN2 ). Fusion Protein ( ... Fusion Protein (10ug). FP-0061. Signosis. Enquire. order. 70 kDa SHP-1L protein. (SH2-Domain - SHP1L-D1). Fusion Protein (10ug) ... Fusion Protein (10ug). FP-0086. Signosis. Enquire. order. Adapter protein GRID. (SH2-Domain - GRID). Fusion Protein (10ug). FP- ...
Chimerin 1. Protein Coding. 16.22. DISEASES inferred 15 GeneCards inferred via :. DISEASES inferred (show sections) ...
... and Cdc42 effector protein 4 gene increased in expression, whereas Arhgap18 and N-chimerin decreased. Several genes the ... The corresponding human protein was identified as an associated protein of the tumor suppressor hDlg and is an in vitro ... Among these are Cyclins B1, D1, D2, the Cell division control protein 2 (Cdc2/p34), and the Cell division cycle protein 20 ( ... Microtubule motor proteins fulfill a specialized function in motor cilia and flagella. In addition, these proteins mediate the ...
Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15). 3cxl. Crystal structure of human chimerin 1 (CHN1). ... are GTPase activating proteins (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases). A ... GAP proteins inactivate small Rho and Ras proteins, so inactivation of rhoGAP proteins might cause constitutive activation of ... Click on the protein counts, or double click on taxonomic names to display all proteins containing RhoGAP domain in the ...
Regulation of chimerin proteins occurs in response to growth factor receptor or G-protein coupled receptor activation followed ... is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in ... is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in ... β-arrestin binding uncouples the receptor from the G protein, thereby terminating G protein-mediated signaling (desensitization ...
N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho GTPase-activating protein 2). ... U4/U6.U5 tri-snRNP-associated protein 3 (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (Nucleic acid-binding protein RY-1 ... Structure: While protein structure does not always reveal much about the function of a gene, such information is often highly ... Motif Matches: A motif or domain match for some portion of the protein. The number and characteristics of each motif or domain ...
... protein_coding gene_symbol:Chn1 description:chimerin (chimaerin) 1 ... cdna:known chromosome:VEGA66:2:73610660:73775346:-1 gene:OTTMUSG00000013428 gene_biotype:protein_coding transcript_biotype: ...
Chimerin 1. Protein Coding. 518.64. Pathogenic 6 Genetic Tests 29 GeneCards inferred via :. Variants (show sections) 17197532 ... An important gene associated with Duane Syndrome Type 2 is CHN1 (Chimerin 1). Affiliated tissues include eye. ...
α-chimaerin (α-chimerin), a Rac-specific GTPase activating protein, plays a key role to wire neurons precisely in the brain. ...
Chimerin Proteins / blood. Dose-Response Relationship, Drug. Female. Humans. Male. Middle Aged. Young Adult ... Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein- ... Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. ... Protein-Tyrosine Kinases / genetics. Protein-Tyrosine Kinases / metabolism. Receptor Protein-Tyrosine Kinases ...
... cyclic AMP response element binding protein 2 , chimerin (chimaerin) 1 ... Protein Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins ... This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c- ... Protein level used designations for ATF2 CREB-2 , activating transcription factor 2 splice variant ATF2-var2 , cAMP response ...
hsa:2888 growth factor receptor bound protein 14 540 177 ( -) 46 0.315 92 -, hsa:1124 chimerin 2 K20630 468 174 ( -) 46 0.333 ... hsa:1741 discs large MAGUK scaffold protein 3 K21098 817 135 ( -) 37 0.326 95 -, hsa:23677 SH3 domain binding protein 4 K20066 ... hsa:1740 discs large MAGUK scaffold protein 2 K12075 870 133 ( -) 36 0.328 67 -, hsa:23504 RIMS binding protein 2 K17591 1052 ... hsa:6464 SHC adaptor protein 1 K06279 583 159 ( -) 42 0.329 82 -, hsa:399694 SHC adaptor protein 4 K17449 630 158 ( -) 42 0.293 ...
... beta chimerin; RhoGAP3; beta-chimerin; beta3-chimaerin; rho-GTPase-activating protein 3; BCH; CHN2-3; MGC138360 ... This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol ( ... DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the ...
The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the ... a pattern that is distinctly different from that of the functionally related n-chimerin gene. In the present study, RNA in situ ... The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the ... The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the ...
chimerin 2 Symbol. chn2 Nomenclature History Previous Names. None Type. protein_coding_gene Location. Chr: 16 Mapping Details/ ... Domain Details Per Protein Protein. Length. Chimaerin. Chimaerin, RhoGAP domain. Chimaerin, SH2 domain. Diacylglycerol/phorbol- ... Protein kinase C-like, phorbol ester/diacylglycerol-binding domain. Rho GTPase-activating protein domain. Rho GTPase activation ...
This protein, called Rgd1p (for related GAP domain), was shown in vitro to be a GTPase activating protein for the Rho3 and Rho4 ... n-chimerin, and rho GAP, all of which have been shown to possess intrinsic GAP activity on small GTPases. Finally, a 778 aa ... The nonessential RGD1 gene encodes a Rho-GTPase activating protein for the Rho3 and Rho4 proteins in Saccharomyces cerevisiae. ... Protein kinase C is mostly regulated by the small GTPase Rho1p in vivo. Pkc1p activates a mitogen-activated protein (MAP) ...
RalA binding protein 1 (RalBP1) [22] and Chimerin (chimaerin) 2 (B-chimaerin), activated by 1,2-diacyl-glycerol (DAG) [23]. Rho ... Rho GTPase activating protein 5 (RhoGAP5) GAP activity is abrogated by RAS p21 protein activator (GTPase activating protein) 1 ... A group of proteins called GTPase-activating proteins (GAPs) inactivates CDC42 by catalyzing the hydrolysis of GTP to GDP. Main ... Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for ...
GEM interacting protein. NM_016573. Gene Info. GNAO1. Guanine nucleotide binding protein (G protein), alpha activating activity ... Chimerin 1. NM_001822. NM_001025201. NM_001206602. Gene Info. CNN3. Calponin 3, acidic. NM_001839. Gene Info. ... Regulator of G-protein signaling 1. NM_002922. Gene Info. RGS10. Regulator of G-protein signaling 10. NM_001005339. NM_002925. ... Regulator of G-protein signaling 22. NM_015668. Gene Info. RGS3. Regulator of G-protein signaling 3. NM_144488. NM_130795. NM_ ...
GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ... GTP-Binding+Protein+Regulators at the US National Library of Medicine Medical Subject Headings (MeSH) ... The inactive form of GTPases (GDP-form) are activated by a class of proteins called Guanosine nucleotide exchange factors (GEFs ...

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