Chimerin 1. Medical search

A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.

A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.

Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.

A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.

Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.

A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.

Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Organized activities related to the storage, location, search, and retrieval of information.

The portion of an interactive computer program that issues messages to and receives commands from a user.

Sequential operating programs and data which instruct the functioning of a digital computer.

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.

Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.

The study of natural phenomena by observation, measurement, and experimentation.

Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.

Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.

Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.

An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.

A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.

Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.

Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.

Sense of awareness of self and of the environment.

Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.

Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.

Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)

A species of ACTINOMYCES found in the oral cavity of man and hamsters. It has been isolated from actinomycotic lesions in swine, cats, and dogs and has been identified as a causative agent of animal diseases.

A plant genus of the family ASTERACEAE. Members contain pectolinarin (a flavonoid glycoside).

The various physical methods which include wind, insects, animals, tension, and water, by which a plant scatters its seeds away from the parent plant.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

An individual that contains cell populations derived from different zygotes.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.

The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.

Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).

A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.

Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. (1/37)

Macrophages respond to Gram-negative bacterial pathogens by phagocytosis and pro-inflammatory gene expression. These responses may require GTPases that have been implicated in cytoskeletal alterations and activation of NF-kappaB. To determine the role of Rac1 and Cdc42 in signal transduction events triggered by Pseudomonas aeruginosa, we expressed GTP binding-deficient alleles of Rac1 or Cdc42, or Chim-GAP, a Rac1/Cdc42-specific GTPase-activating protein domain, in a subline of RAW 264.7 cells, and challenged the transfected cells with a laboratory strain of P. aeruginosa, PAO1. Expression of Rac1 N17, Cdc42 N17, or Chim-GAP led to a marked reduction of phagocytosis. In contrast, nuclear translocation of p65 NF-kappaB was unaffected by expression of the same constructs. Incubation of macrophages with PAO1 led to NF-kappaB-dependent expression of inducible nitric-oxide synthase, COX-2, and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function. Isogenic strains of PAO1 that lacked surface adhesins were poorly ingested; however, they induced pro-inflammatory gene expression with an efficiency equal to that of PAO1. These results indicate that the signal transduction events leading to phagocytosis and pro-inflammatory protein expression are distinct. Rac1 and Cdc42 serve as effectors of phagocytosis, but not NF-kappaB-dependent gene expression, in the macrophage response to P. aeruginosa. (+info)

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. (2/37)

Neuronal differentiation involves Rac and Cdc42 GTPases. alpha-Chimaerin, a Rac/Cdc42 regulator, occurs as alpha1- and alternatively spliced Src homology 2 (SH2) domain-containing alpha2-isoforms. alpha2-chimaerin mRNA was highly expressed in the rat embryonic nervous system, especially in early postmitotic neurons. alpha1-chimaerin mRNA was undetectable before embryonic day 16.5. Adult alpha2-chimaerin mRNA was restricted to neurons within specific brain regions, with highest expression in the entorhinal cortex. alpha2-chimaerin protein localized to neuronal perikarya, dendrites, and axons. The overall pattern of alpha2-chimaerin mRNA expression resembles that of cyclin-dependent kinase regulator p35 (CDK5/p35) which participates in neuronal differentiation and with which chimaerin interacts. To determine whether alpha2-chimaerin may have a role in neuronal differentiation and the relevance of the SH2 domain, the morphological effects of both chimaerin isoforms were investigated in N1E-115 neuroblastoma cells. When plated on poly-lysine, transient alpha2-chimaerin but not alpha1-chimaerin transfectants formed neurites. Permanent alpha2-chimaerin transfectants generated neurites whether or not they were stimulated by serum starvation, and many cells were enlarged. Permanent alpha1-chimaerin transfectants displayed numerous microspikes and contained F-actin clusters, a Cdc42-phenotype, but generated few neurites. In neuroblastoma cells, alpha2-chimaerin was predominantly soluble with some being membrane-associated, whereas alpha1-chimaerin was absent from the cytosol, being membrane- and cytoskeleton-associated, paralleling their subcellular distribution in brain. Transient transfection with alpha2-chimaerin mutated in the SH2 domain (N94H) generated an alpha1-chimaerin-like phenotype, protein partitioned in the particulate fraction, and in NGF-stimulated pheochromocytoma cell line 12 (PC12) cells, neurite formation was inhibited. These results indicate a role for alpha2-chimaerin in morphological differentiation for which its SH2 domain is vital. (+info)

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. (3/37)

Human n-chimaerin is a GTPase-activating protein (GAP) for p21rac and a phorbol ester receptor. We have isolated rat n-chimaerin cDNA and investigated the cellular and developmental pattern of mRNA expression in the brain. There is extensive sequence conservation with human n-chimaerin in the coding region and the first 400 nucleotides of the 3'-untranslated region (UTR) (90% and 83% identity respectively). The rat cDNA encodes an additional 35 N-terminal amino acids compared with the reported human cDNA, which has a 5'-UTR sequence inversion and a 41-nucleotide deletion including the putative initiator methionine. The rat cDNA encodes a 334-amino acid protein (38200 M(r), pI 8.04) with 97% amino acid sequence identity with the human protein, after correction of the human 5'-DNA sequence. n-Chimaerin mRNA was detectable in embryonic rat brain at day 15 and increased in amount postnatally from birth to 20 days, coincident with cellular differentiation and synaptogenesis. n-Chimaerin mRNA is restricted to neurons, with highest concentrations in hippocampal pyramidal cells, granule cells of the dentate gyrus and cortical neurons. In the cerebellum the mRNA was detected only in Purkinje neurons. The pattern and specificity of mRNA expression suggests an important role for n-chimaerin in neuronal signal-transduction mechanisms. (+info)

Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. (4/37)

Cyclin-dependent kinase 5 (Cdk5) in association with its neuronal activators p35 and p39 shows a complex involvement in the control of neurocytoskeletal dynamics. Here we show that alpha-chimaerin, a GTPase-activating protein specific for Rac and Cdc42, is a p35-binding protein. The interaction domains of p35 and alpha-chimaerin were delineated. In transfected HeLa cells, p35 and alpha-chimaerin displayed an overlapping distribution pattern and they could be co-immunoprecipitated from the cell lysate. As alpha-chimaerin has a regulatory function in actin repolymerization, these results suggested that the regulation of neurocytoskeleton dynamics by Cdk5 is mediated at least in part via alpha-chimaerin. (+info)

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (5/37)

Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP)alpha2-chimaerin is involved in Semaphorin 3A (Sema 3A) signaling. In dorsal root ganglion neurons, Sema 3A-induced growth cone collapse was inhibited by alpha2-chimaerin mutated to eliminate GAP activity or interaction with phosphotyrosine. Activation of alpha2-chimaerin by phorbol ester caused growth cone collapse. Active alpha2-chimaerin interacts with collapsin response mediator protein-2 (CRMP-2) and cyclin-dependent kinase (Cdk) 5/p35 kinase through its SH2 and GAP domains, respectively. Cdk5 phosphorylates CRMP-2 at serine 522, possibly facilitating phosphorylation of serine 518 and threonine 514 by glycogen synthase kinase 3beta (GSK3beta), a kinase previously implicated in Sema 3A signaling. Phosphorylation of CRMP-2 serine 522 was essential for Sema 3A-induced growth cone collapse, which is dependent on Cdk5 but not Rho kinase activity. alpha2-chimaerin, like CRMP-2, can associate with the Sema 3A receptor. These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling. (+info)

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. (6/37)

Abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. The key regulators of cytoskeletal reorganization in dendrites and spines are the Rho GTPases, which modify actin polymerization in response to synaptic signaling. Rho GTPase activity is modulated by multiple regulatory proteins, some of which have been found to associate with proteins localized to spines. Here, we show that the nonkinase phorbol ester receptor alpha1-chimerin is present in dendrites and spines, where it binds to the NMDA receptor NR2A subunit in a phorbol ester-dependent manner. Alpha1-chimerin contains a GTPase activating (GAP) domain, with activity toward the Rho family member Rac1. Overexpression of alpha1-chimerin in cultured hippocampal neurons inhibits formation of new spines and removes existing spines. This reduction in spine density is mediated by Rac1 inhibition, because it depends critically on the presence of a functional GAP domain. Conversely, depletion of alpha1-chimerin leads to an increase in spine density, indicating that a basal inhibition of Rac1 maintains the number of spines at a submaximal level. The ability of alpha1-chimerin to modulate spine number requires an interaction with the NMDA receptor, because an alpha1-chimerin mutant that binds weakly to NR2A fails to decrease spine density. Together, these results suggest that alpha1-chimerin is able to modulate dendritic spine morphology by binding to synaptic NMDA receptors and locally inactivating Rac1. (+info)

The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. (7/37)

The morphological and functional differentiation of neuronal dendrites is controlled through transcriptional programs and cell-cell signaling. Synaptic activity is thought to play an important role in the maturation of dendritic arbors, but the signaling pathways that couple neuronal activity and morphological changes in dendrites are not well understood. We explored the function of alpha1-chimaerin, a neuronal diacylglycerol-binding protein with a Rho GTPase-activating protein domain that inactivates Rac1. We find that stimulation of phospholipase Cbeta-coupled cell surface receptors recruits alpha1-chimaerin to the plasma membrane of cultured hippocampal neurons. We further show that alpha1-chimaerin protein levels are controlled by synaptic activity and that increased alpha1-chimaerin expression results in the pruning of dendritic spines and branches. This pruning activity requires both the diacylglycerol-binding and Rac GTPase-activating protein activity of alpha1-chimaerin. Suppression of alpha1-chimaerin expression resulted in increased process growth from the dendritic shaft and from spine heads. Our data suggest that alpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors. (+info)

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding. (8/37)

Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes. DG is produced transiently as it is rapidly metabolized by DG kinase (DGK) to phosphatidic acid. Phorbol esters such as PMA are not metabolized and induced a prolonged membrane association of PKC. Until recently, PKC was the only known phorbol ester receptor. We have shown that a novel brain-specific cDNA, neuronal chimaerin (NC), expressed in Escherichia coli, binds phorbol ester with high affinity, stereospecificity and a phospholipid requirement [Ahmed, Kozma, Monfries, Hall, Lim, Smith & Lim (1990) Biochem. J. 272, 767-773]. The proteins NC, PKC and DGK possess a cysteine-rich domain with the motif HX11/12CX2CXnCX2CX4HX2CX6/7C (where n varies between 12 and 14). The partial motif, CX2CX13CX2C, is present in a number of transcription factors including the steroid hormone receptors and the yeast protein, GAL4, in which zinc plays a structural role of co-ordinating cysteine residues and is essential for DNA binding (protein-nucleic acid interactions). The cysteine-rich domain of NC and PKC is required for phospholipid-dependent phorbol is required for phospholipid-dependent phorbol ester binding, suggesting an involvement of this domain in protein-lipid interactions. We have expressed recombinant NC, PKC and DGK glutathione S-transferase and TrpE fusion proteins in E. coli to investigate the relationship between the cysteine-rich motif, HX11/12CX2CX10-14CX2CX4HX2CX6/7C, zinc and phorbol ester binding. The cysteine-rich domain of NC, PKC and DGK bound 65Zn2+ but only NC and PKC bound [3H]phorbol 12,13-dibutyrate. When NC and PKC were subjected to treatments known to remove metal ions from GAL4 and the human glucocorticoid receptor, phorbol ester binding was inhibited. These data provide evidence for the role of a zinc-dependent structure in phorbol ester binding. (+info)

... chimerin 1 MeSH D12.776.402.150.500.460 - neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH ... neuregulin-1 See List of MeSH codes (D12.776.476). MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280. ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

... two known genetic associations with Duane Syndrome In some families the condition is associated with variants in the Chimerin 1 ...

https://en.wikipedia.org/wiki/Duane_syndrome

... chimerin proteins MeSH D12.776.476.325.150.100.200 - chimerin 1 MeSH D12.776.476.325.150.300 - eukaryotic initiation factor-5 ... adp-ribosylation factor 1 MeSH D12.776.476.525.400.025 - rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 - rab2 gtp- ... caspase 1 MeSH D12.776.476.075.437.500 - neuronal apoptosis-inhibitory protein MeSH D12.776.476.075.437.750 - x-linked ... interferon regulatory factor-1 MeSH D12.776.476.024.389.249 - interferon regulatory factor-2 MeSH D12.776.476.024.389.374 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)

... chimerin proteins MeSH D12.644.360.325.150.100.200 - chimerin 1 MeSH D12.644.360.325.150.300 - eukaryotic initiation factor-5 ... map kinase kinase 1 MeSH D12.644.360.440.200 - map kinase kinase 2 MeSH D12.644.360.440.300 - map kinase kinase 3 MeSH D12.644. ... ADP-ribosylation factor 1 MeSH D12.644.360.525.400 - rab gtp-binding proteins MeSH D12.644.360.525.400.025 - rab1 gtp-binding ... interleukin-1 MeSH D12.644.276.174.500.800 - tumor necrosis factor-alpha MeSH D12.644.276.174.750 - tumor necrosis factors MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)

α2-Chimerin acts in a similar manner to α1-Chimerin, but is primarily found in the brain and testes. It is also an SH2 ... β2-chimerin has been shown to play a role in breast cancer. In breast cancer cells the amount of β2-chimerin messengers are ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... Chimerin is a type of nerve tissue protein. Chimerins are a family of non-PKC phorbol-ester receptors. They were the first to ...

https://en.wikipedia.org/wiki/Chimerin

... n-chimerin is a protein which in humans is encoded by the CHN1 gene. Chimerin 1 is a GTPase activating protein specific for RAC ... GeneReviews/NCBI/NIH/UW entry on Duane syndrome Chimerin+1 at the US National Library of Medicine Medical Subject Headings ( ... Crystal structure of human chimerin 1 (CHN1)". Hall C, Monfries C, Smith P, Lim HH, Kozma R, Ahmed S, Vanniasingham V, Leung T ... 1754 (1-2): 296-304. doi:10.1016/j.bbapap.2005.07.034. PMID 16202672. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan ...

https://en.wikipedia.org/wiki/Chimerin_1

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... "Entrez Gene: CHN2 chimerin (chimaerin) 2". Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization ... 2005). "Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin". J. Biol. Chem. 280 (26): 24363- ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ...

https://en.wikipedia.org/wiki/Chimerin_2

1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and ... 43 (1): 107-9. doi:10.1006/geno.1997.4776. PMID 9226381. "Entrez Gene: MYO9B myosin IXB". Bement WM, Hasson T, Wirth JA, et al ...

https://en.wikipedia.org/wiki/MYO9B

According to the CEO Lawrence Chimerin, the term "econometrics" was dropped, because the consolidated company would broaden its ... April 1, 1987: WEF Associates AG, the parent of Wharton Econometric Forecasting Associates, announced that it acquired Chase ...

https://en.wikipedia.org/wiki/Wharton_Econometric_Forecasting_Associates

Agrin Chimerin Proteins Chromogranins Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 ...

https://en.wikipedia.org/wiki/Nerve_tissue_protein

Chimerin 2. *Α-シヌクレイン. *CD4. Metadata. This file contains additional information, probably added from the digital camera or ... 13:54, 1 August 2017. 453 × 200 (10.31 MB). Was a bee. {{Information ,Description={{en,1=Ideogram of house mouse (''Mus ...

https://en.wikipedia.org/wiki/File:Ideogram_house_mouse_chromosome_6.svg

doi:10.1007/978-1-4615-4869-0_6. PMID 10079839.. *^ a b Benowitz LI, Routtenberg A (1987). "A membrane phosphoprotein ... 22 (1): 239-47. PMID 11756507.. *^ Grasselli G, Mandolesi G, Strata P, Cesare P (June 2011). "Impaired sprouting and axonal ... 317 (1): 219-24. doi:10.1042/bj3170219. PMC 1217466 . PMID 8694767.. *. Kanazir S, Ruzdijic S, Vukosavic S, Ivkovic S, ... doi:10.1016/0896-6273(88)90196-1. PMID 3272162.. *. Ng SC, de la Monte SM, Conboy GL, Karns LR, Fishman MC (Apr 1988). "Cloning ...

https://en.wikipedia.org/wiki/GAP-43

27 (1): 168-70. doi:10.1017/S1041610214001616. PMC 4501575. PMID 25101659.. *^ a b Nykjaer A, Lee R, Teng KK, Jansen P, Madsen ... 978-0-444-51472-1. . PMID 14699960.. *^ a b c Lee R, Kermani P, Teng KK, Hempstead BL (Nov 2001). "Regulation of cell survival ... 8 (1): 43-48. PMC 3749761. PMID 24023598.. *^ a b Wiesmann C, Ultsch MH, Bass SH, de Vos AM (September 1999). "Crystal ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ...

https://en.wikipedia.org/wiki/Nerve_growth_factor

They are active or 'ON' when it is bound to GTP and inactive or 'OFF' when bound to GDP.[1] Activation and deactivation of ...

https://en.wikipedia.org/wiki/GTP-binding_protein_regulators

https://en.wikipedia.org/wiki/Chimerin_1

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing ... Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007 Aug ... of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol Cell Biol. 1993 Aug;13(8):4986-98. ... Page last updated on 18 August 2020 Page last reviewed: 1 March 2009 ...

https://medlineplus.gov/genetics/gene/chn1/

... chimerin (chimaerin) 1 ...

http://www.informatics.jax.org/sequence/OTTMUST00000032446

https://en.wikipedia.org/wiki/Chimerin

Chimerin 1. NM_001822. NM_001025201. NM_001206602. Gene Info. CNN3. Calponin 3, acidic. NM_001839. Gene Info. ... Arrestin, beta 1. NM_004041. NM_020251. Gene Info. ASAP1. ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. NM_001247996 ... Thy-1 cell surface antigen. NM_006288. Gene Info. TMED2. Transmembrane emp24 domain trafficking protein 2. NM_006815. Gene Info ... Ras interacting protein 1. NM_017805. Gene Info. RGN. Regucalcin (senescence marker protein-30). NM_152869. NM_004683. Gene ...

https://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0030811

Chimerin-1. CpG:. Cytosine-phosphate-guanine. COL4A5:. Collagen type IV alpha 5 chain ... Table 1 Differentially methylated cytosines (DMCs) found in this study between pre- and post-challenge sea bass. Full size ... 1. Hierarchical clustering based on of the 57 differentially methylated cytosines detected in this study. Capital letters refer ... One other groups of two cytosines were found in the same exon (distant by 3 bp) of the BTR30 gene (Table 1). A single DMC was ...

https://rd.springer.com/article/10.1186/s12864-021-07420-9?error=cookies_not_supported&code=42d2ee23-d9c5-4f54-9521-beef7e298d40

Protein Aliases: A-chimaerin; a2-chimaerin; Alpha-chimerin; alpha1 chimaerin; alpha2 chimaerin; alpha3-chimerin; chimaerin; ... N-chimerin; NC; Rho GTPase-activating protein 2 Gene Aliases: 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik; ...

https://www.thermofisher.com/antibody/product/CHN1-Antibody-clone-OTI3C6-Monoclonal/CF505109

Chimerin 1. Protein Coding. 16.22. DISEASES inferred 15 GeneCards inferred via :. DISEASES inferred (show sections) ... The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... SALL4, 1-BP DEL, 1904T deletion. Pathogenic. 6. SALL4 NM_020436.4(SALL4): c.2593C, T (p.Arg865Ter) single nucleotide variant. ... SALL4, 1-BP DEL, 326C deletion. Pathogenic. 10. SALL4 NM_020436.4(SALL4): c.523A, T (p.Lys175Ter) single nucleotide variant. ...

https://www.malacards.org/card/duane_radial_ray_syndrome

Crystal structure of human chimerin 1 (CHN1). 3eap. Crystal structure of the RhoGAP domain of ARHGAP11A. ... This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which ... Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. ... Inositol polyphosphate 5-phosphatase OCRL-1 (Q01968) (SMART). OMIM:309000: Lowe syndrome. ...

http://smart.embl-heidelberg.de/smart/do_annotation.pl?ACC=SM00324

Crystal structure of human chimerin 1 (CHN1). 3eac. Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase ... TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX. 1bfi. SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY ... Crystal structure of human tyrosine phosphatase SHP-1. 2bbu. solution structure of mouse socs3 in complex with a phosphopeptide ... The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T ...

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&DOMAIN=SM00252

Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) CHN2 ARHGAP3, BCH ... 1.10.555.10, 1 hit. InterProi. View protein in InterPro. IPR020454, DAG/PE-bd. IPR002219, PE/DAG-bd. IPR008936, Rho_GTPase_ ... SSF48350, SSF48350, 1 hit. PROSITEi. View protein in PROSITE. PS50238, RHOGAP, 1 hit. PS00479, ZF_DAG_PE_1, 1 hit. ... 1 - 260. Rho-GAPInterPro annotation. ,p>Information which has been generated by the UniProtKB automatic annotation system, ...

https://www.uniprot.org/uniprot/B3VCF5

Bos taurus chimerin (chimaerin) 1 (CHN1), transcript variant 2, mRNA. Assay Type: SYBR® Green Assay Design: Intron-spanning ... Bos taurus chimerin (chimaerin) 1 (CHN1), transcript variant 2, mRNA. Assay Type: Probe Assay Design: Intron-spanning ...

http://www.bio-rad.com/en-us/prime-pcr-assays/gene/chn1-cow

hsa:1123 chimerin 1 K20630 459 168 ( -) 44 0.337 83 -, hsa:342667 SH3 and cysteine rich domain 2 411 168 ( -) 44 0.436 55 -, ... hsa:1124 chimerin 2 K20630 468 174 ( -) 46 0.333 87 -, hsa:10580 sorbin and SH3 domain containing 1 K06086 1292 172 ( -) 45 ... hsa:274 bridging integrator 1 K12562 593 101 ( -) 29 0.328 67 -, [ SSDB , GENES , KEGG2 , KEGG , GenomeNet ] ... hsa:54869 EPS8 like 1 K17277 723 132 ( -) 36 0.351 57 -, hsa:28988 drebrin like K20520 430 131 ( -) 36 0.364 55 -, hsa:30837 ...

http://www.kegg.jp/ssdb-bin/ssdb_paralog?org_gene=hsa:2885

chimerin (chimaerin) 1 Aliases:. ARHGAP2, CHN, DURS2, RHOGAP2 RefSeq:. NC_000002.11 NT_005403.17 NG_012642.1 ...

http://www.bio-rad.com/en-us/prime-pcr-assays/assay/dhsaeg5018631-primepcr-ddpcr-expression-evagreen-assay-chn1-human

chimerin (chimaerin) 1. NM_030237. 84654. SPZ1. spermatogenic leucine zipper 1. NM_030889. 57537. SORCS2. sortilin-related ...

http://software.broadinstitute.org/gsea/msigdb/cards/SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5.html

An important gene associated with Duane Syndrome Type 2 is CHN1 (Chimerin 1). Affiliated tissues include eye. ... The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... 1. CHN1 NM_001822.5(CHN1): c.60A, T (p.Leu20Phe) single nucleotide variant. Pathogenic. rs121912792 GRCh37. Chromosome 2, ... Diseases in the Duane Syndrome Type 1 family:. Duane Syndrome Type 2 Duane Syndrome Type 3 ...

https://www.malacards.org/card/duane_syndrome_type_2

CHN1: chimerin 1. *CHRNA2: cholinergic receptor nicotinic alpha 2 subunit. *CHRNA4: cholinergic receptor nicotinic alpha 4 ... CYP27B1: cytochrome P450 family 27 subfamily B member 1. Genetics Home Reference has merged with MedlinePlus. Genetics Home ... CYP27A1: cytochrome P450 family 27 subfamily A member 1. * ... CLRN1: clarin 1. *CNBP: CCHC-type zinc finger nucleic acid ... CYP24A1: cytochrome P450 family 24 subfamily A member 1. * ... CRB1: crumbs 1, cell polarity complex component. *CREBBP: CREB ...

https://medlineplus.gov/genetics/gene-c/

In B16 transplantable mouse melanoma, chimerin overexpression or exogenous injection in the context of its chemokine-like ... Whole genome expression datasets confirmed that chimerin was prognostic of improved outcome in melanoma patients and expression ... A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood (2012) 120(22):4317-23. doi:10.1182 ... The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity (1998) 9(4):555-63. ...

https://www.frontiersin.org/articles/10.3389/fimmu.2015.00202/full

"Chimerin Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Chimerin Proteins" by people in UAMS Profiles by year, and ... Below are the most recent publications written about "Chimerin Proteins" by people in Profiles over the past ten years. ... Below are MeSH descriptors whose meaning is more general than "Chimerin Proteins". ...

https://uams-triprofiles.uams.edu/profiles/display/124238

Chimerin (chimaerin) 1 Probe n°212624_s_at Gene Aliases : CHN, ARHGAP2, RHOGAP2. Chromosome Localization : 2q31.1. Gene Number ... 1) Sheng Y et al. - Comparison of different karyotypic chHES-3 cells - GEO - GSE7234 - 2007. (2) Baker DE et al. - Adaptation ... 1) Assou et al. - Unpublished data - - 2005. (2) Golan-Mashiach et al. - Design principle of gene expression used by human - ... 1;293:90 - 2006. (7) Perez-Iratxeta et al. - Study of stem cell function using microarray experiments - FEBS Letters 579:1795 ...

http://amazonia.transcriptome.eu/expression.php?probeId=212624_s_at

1996) Human myosin IX-b. An unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J ... Amino acid numbering for ankyrin repeats is as follows: 1, G59-S91; 2, S92-E124;3, D125-V157; 4, N158-S189;5, L190-D220; 6, ... 1. N-terminal extension of myr 8a shows eight ankyrin repeat sequences. Alignment of the myr 8a clone 4 sequence with the ... Sequence 1 was generated using a sense primer common to both myr 8a and KIAA0865 with an antisense primer unique to 3′- ...

https://www.jneurosci.org/content/21/20/7954

... chimerin (chimaerin) 1 ... Interleukin 1 alpha (IL1A) * Insulin-Like Growth Factor 1 (IGF1 ... 1 877 302 8632. Fax:. +1 888 205 9894 (Toll-free). E-Mail:. [email protected] ...

https://www.antibodies-online.com/mapk-signaling-pathway-3/atf2-elisa-kit-23/

Chimerin 1. Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) ...

https://string-db.org/network/7897.ENSLACP00000002503

chimerin (chimaerin) 1. 0.015. tmco1. transmembrane and coiled-coil domains 1. 0.015. ... solute carrier family 1 (glial high affinity glutamate transporter), member 2b. 0.014. ... ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1). 0.054. ... jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae). 0.012. ...

http://imp.princeton.edu/predictions/process/zebrafish-context-global/5681/?gene=33599

Regulation of chimerin proteins occurs in response to growth factor receptor or G-protein coupled receptor activation followed ... Monoclonal Antibody - β2-Chimerin (2E3) Rat mAb - Western Blotting, UniProt ID P52757, Entrez ID 1124 #4728 ... β2-chimerin is also down-regulated in breast cancer, and its expression causes GAP activity-dependent cell cycle arrest in MCF- ... β2-chimerin is highly expressed in brain and pancreas, and its expression is down-regulated in malignant gliomas (3). ...

https://www.cellsignal.com/1/1/indexe194.html

Chimerin 1 - RasGAP (Neurofibromin 1, IQ motif containing GTPase activating protein). Guanine nucleotide exchange factor. EIF-2 ...

https://www.chemeurope.com/en/encyclopedia/Guanine_nucleotide_exchange_factor.html

1. a. An organism, organ, or part consisting of two or more tissues of different genetic composition, produced as a result of ... 1. The individual produced by grafting an embryonic part of one animal onto the embryo of another, either of the same or of ... As expected, harboring at least one In2G mutation (as in chimeras CH-1, CH-2, CH-3, CH-5, CH-6, and the newly identified CH-8) ... 1. In experimental embryology, the individual produced by grafting an embryonic part of one animal onto the embryo of another, ...

http://medical-dictionary.thefreedictionary.com/Chimeras

1. To cause to be united in marriage or a romantic sexual relationship. ...

http://medical-dictionary.thefreedictionary.com/Chimarr%C3%A3o

CHN2; chimerin (chimaerin) 2; beta-chimaerin; ARHGAP3; beta chimerin; RhoGAP3; beta-chimerin; beta3-chimaerin; rho-GTPase- ... This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ...

https://www.creative-biogene.com/symbolsearch_chn2.html

Transient overexpression lysate of chimerin (chimaerin) 1 (CHN1), transcript variant 1 *Transient overexpression lysate of ...

http://www.origene.com/shRNA/TG313931.aspx

Chimaerin CHN1 GTPase Genes Proteins Phorbol ester Subunit Homolog Regulates Isoforms Vitro Encodes Insulin Tissues Duane Selectively Diseases Chromosome Diabetic retinopathy Human Gamma Family Testes Type

N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho GTPase-activating protein 2). (cisreg.ca)
α-chimaerin (α-chimerin), a Rac-specific GTPase activating protein, plays a key role to wire neurons precisely in the brain. (jnss.org)

Chimerin 1, (CHN1) also known as alpha-1-chimerin, n-chimerin is a protein which in humans is encoded by the CHN1 gene. (wikipedia.org)
An important gene associated with Duane Syndrome Type 2 is CHN1 (Chimerin 1). (malacards.org)

Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. (wikipedia.org)
Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. (medlineplus.gov)
α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. (wikipedia.org)
This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)
A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
Two factors concur to determine specific Rho GTPase function: tissue specificity of GTPase effectors and distinct intracellular localizations of closely related Rho GTPases, due to different lipid modifications [ 1 ]. (biomedcentral.com)
Rho GTPase activating protein 5 ( RhoGAP5 ) GAP activity is abrogated by RAS p21 protein activator (GTPase activating protein) 1 ( p120GAP ) binding [25] , [26] . (pathwaymaps.com)
Fibroblast growth factor receptor 1 ( FGFR1 ) can regulate activity of CDC42 by binding to BCL2/adenovirus E1B 19kDa interacting protein 2 ( NIP2 ) coupled with Rho GTPase activating protein 1 ( RhoGAP1 ) and removing their inhibitory GAP activity from CDC42 [27] . (pathwaymaps.com)
A second example is haploinsufficiency for the insulin receptor (IR) in combination with chimerin-2 a GTPase-activating protein (CHN2) that results in insulin resistance and deficiency in interuterine growth (2). (ac-devd-cho.com)
We identified both growth inhibitors (Ephexin, Aldolase A, Solute Carrier 2A3, and Chimerin), and growth enhancers (Doublecortin, Doublecortin-like, Kruppel-like Factor 6, and CaM-Kinase II gamma), some of which regulate established growth mechanisms like microtubule dynamics and small GTPase signaling. (elsevier.com)

One of these is due to heterozygous mutations in 2 unlinked genes, peroxisome proliferator receptor gamma (PPARG) and protein phosphatase 1, regulatory (inhibitor) subunit 3A (PPP1R3A), expressed in adipocytes and skeletal muscle respectively and results in severe insulin resistance and lipodystrophy (1). (ac-devd-cho.com)

Chimerin 1 Chimerin 2 Chimerin+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Van de Ven, Thomas J. (wikipedia.org)
Chimerin Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Chimerin Proteins" by people in UAMS Profiles by year, and whether "Chimerin Proteins" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Chimerin Proteins" by people in Profiles over the past ten years. (uams.edu)
Because molecular motor proteins have been implicated in a wide spectrum of processes associated with cell motility, we initiated studies to define the pool of myosins in migrating cerebellar granule neurons and type-1 neocortical astrocytes. (jneurosci.org)
Smith GS, Homchaudhuri L, Boggs JM, Harauz G. Classic 18.5- and 21.5-kDa myelin basic protein isoforms associate with cytoskeletal and SH3-domain proteins in the immortalized N19-oligodendroglial cell line stimulated by phorbol ester and IGF-1. (sickkids.ca)

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. (creative-biogene.com)

α1-Chimerin is also able to regulate dendritic spinal density by binding to NMDA receptors at the NR2A subunit. (wikipedia.org)

FAT tumor suppressor homolog 1 (Droso. (broadinstitute.org)

Variants within the engulfment and motility 1 ( ELMO1 ) gene, whose protein regulates cell migration and matrix and TGFβ expression, have been associated with diabetic nephropathy phenotypes and are located within the linkage signal on 7p. (kidneynews.org)
It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE. (umassmed.edu)

There are four known isoforms of the Chimerin protein. (wikipedia.org)

In principle, the in vitro differentiation of neurosphere-forming cells includes five steps: (1) cessation of proliferation, (2) attachment of the neurosphere, (3) detachment of cells from the neurosphere cell cluster, (4) migration of these cells away from the sphere, and (5) their actual differentiation into different cell types. (jneurosci.org)

Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (embl-heidelberg.de)
Further mapping of the 18q regions subsequently identified carnosinase 1, a gene that encodes an enzyme whose substrate inhibits ACE activity and advanced glycation end product formation, as a diabetic nephropathy susceptibility gene. (kidneynews.org)

β2-chimerin can be linked to a fusion gene that is associated with a key insulin receptor that causes people to have decreased levels of insulin. (wikipedia.org)
In a LY2940680 mouse model, a digenic insulin resistance phenotype has been described whereby 40% of mice heterozygous for both insulin receptor (IR) and insulin receptor substrate-1 (IRS-1) null alleles develop overt diabetes at 4-6 months of age demonstrating how two mild impairments in the same pathway can interact to cause diabetes (4). (ac-devd-cho.com)
This is instigated either by complete lack of insulin production (type 1 diabetes), reduced level of insulin production (type 2 diabetes) or insulin resistance (inability of body cells to take up glucose). (geneticsmr.org)
CHN2 encoding beta-2 chimerin was shown to be expressed in insulin-sensitive tissues, and its disruption was shown to result in decreased gene expression in patient-derived adipose tissue. (eurekamag.com)

Although stem cell properties have been characterized in many tissues ( 1 ), we are only beginning to understand how stem cell function is regulated at the molecular level. (sciencemag.org)

GeneReviews/NCBI/NIH/UW entry on Duane syndrome Chimerin+1 at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)

The structural features and restricted expression patterns suggest that members of this novel class of unconventional myosins comprise a mechanism to target selectively the protein phosphatase 1 catalytic subunits 1α and/or 1γ in developing brain. (jneurosci.org)

Cancer is a generic group of over 100 diseases unified by fundamental characteristics acquired during their clonal evolution ( 1 ), including tumor-promoting inflammation and escape from immune surveillance ( 2 , 3 ). (frontiersin.org)
Many common diseases, including nephropathy, cluster in families, and genetic variants seem likely to regulate disease pathogenesis ( 1 ). (kidneynews.org)

1=Ideogram of house mouse (''Mus musculus'') chromosome. (wikipedia.org)

Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients. (nih.gov)

Sevilla, Santos, Vega, Lazo: Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. (anticorps-enligne.fr)
Orthologous to human CHN2 (chimerin 2). (zfin.org)
In direct ELISAs, less than 1 % cross-reactivity with recombinant human (rh) CXCL16, rhFractalkine, recombinant mouse Fractalkine, and recombinant rat Fractalkine is observed. (antibodies-online.com)

We used a two-stage study design to evaluate whether variations in the peroxisome proliferator-activated receptors (PPAR) and the PPAR gamma co-activator 1 (PGC1) gene families (PPARA, PPARG, PPARD, PPARGC1A, and PPARGC1B) are associated with type 2 diabetes (T2D) risk. (jove.com)

aldehyde dehydrogenase 1 family, memb. (broadinstitute.org)

α2-Chimerin acts in a similar manner to α1-Chimerin, but is primarily found in the brain and testes. (wikipedia.org)

Chimerin is a type of nerve tissue protein. (wikipedia.org)
To further elucidate the role of myosins in the process of neuronal cell migration, we initiated studies to define the pool of myosins in migrating cerebellar granule neurons and type-1 neocortical astrocytes. (jneurosci.org)
cadherin 2, type 1, N-cadherin (neuro. (broadinstitute.org)
G-protein coupled receptor 143 (Ocular albinism type 1 protein). (cisreg.ca)
Instillation of 1% pilocarpine hydrochloride into the eye shrank the pupil by 80% in wild-type mice, whereas miffy mice exhibited less than 40% shrinking of the pupil. (jnss.org)

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Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. (1/37)

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. (2/37)

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. (3/37)

Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. (4/37)

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (5/37)

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. (6/37)

The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. (7/37)

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding. (8/37)

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Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. (1/37)

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. (2/37)

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. (3/37)

Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. (4/37)

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (5/37)

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. (6/37)

The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. (7/37)

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding. (8/37)

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor...

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