Chimerin 1: A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.Chimerin Proteins: A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.Proto-Oncogene Proteins c-bcr: Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.ras GTPase-Activating Proteins: PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.Chromosomes, Human, Pair 2: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Spermatocytes: Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.rac GTP-Binding Proteins: A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.GTPase-Activating Proteins: Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.Protein Kinase C: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.United StatesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Templates, Genetic: Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.Science: The study of natural phenomena by observation, measurement, and experimentation.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Methanosarcina barkeri: A species of halophilic archaea whose organisms are nonmotile. Habitats include freshwater and marine mud, animal-waste lagoons, and the rumens of ungulates.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Semiconductors: Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.Aspergillus oryzae: An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Microfluidics: The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.Microfluidic Analytical Techniques: Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.Prenatal Diagnosis: Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Chimera: An individual that contains cell populations derived from different zygotes.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Duane Retraction Syndrome: A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.Abducens Nerve: The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.Aristolochic Acids: Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).Ophthalmic Nerve: A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.Activating Transcription Factor 3: An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.Activating Transcription Factor 4: An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Activating Transcription Factors: Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.Activating Transcription Factor 6: One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.Activating Transcription Factor 2: An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.Activating Transcription Factor 1: An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Program Evaluation: Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.Drug Discovery: The process of finding chemicals for potential therapeutic use.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)Nuclear Physics: The study of the characteristics, behavior, and internal structures of the atomic nucleus and its interactions with other nuclei. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)cdc25 Phosphatases: A subclass of dual specificity phosphatases that play a role in the progression of the CELL CYCLE. They dephosphorylate and activate CYCLIN-DEPENDENT KINASES.

Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. (1/37)

Macrophages respond to Gram-negative bacterial pathogens by phagocytosis and pro-inflammatory gene expression. These responses may require GTPases that have been implicated in cytoskeletal alterations and activation of NF-kappaB. To determine the role of Rac1 and Cdc42 in signal transduction events triggered by Pseudomonas aeruginosa, we expressed GTP binding-deficient alleles of Rac1 or Cdc42, or Chim-GAP, a Rac1/Cdc42-specific GTPase-activating protein domain, in a subline of RAW 264.7 cells, and challenged the transfected cells with a laboratory strain of P. aeruginosa, PAO1. Expression of Rac1 N17, Cdc42 N17, or Chim-GAP led to a marked reduction of phagocytosis. In contrast, nuclear translocation of p65 NF-kappaB was unaffected by expression of the same constructs. Incubation of macrophages with PAO1 led to NF-kappaB-dependent expression of inducible nitric-oxide synthase, COX-2, and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function. Isogenic strains of PAO1 that lacked surface adhesins were poorly ingested; however, they induced pro-inflammatory gene expression with an efficiency equal to that of PAO1. These results indicate that the signal transduction events leading to phagocytosis and pro-inflammatory protein expression are distinct. Rac1 and Cdc42 serve as effectors of phagocytosis, but not NF-kappaB-dependent gene expression, in the macrophage response to P. aeruginosa.  (+info)

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. (2/37)

Neuronal differentiation involves Rac and Cdc42 GTPases. alpha-Chimaerin, a Rac/Cdc42 regulator, occurs as alpha1- and alternatively spliced Src homology 2 (SH2) domain-containing alpha2-isoforms. alpha2-chimaerin mRNA was highly expressed in the rat embryonic nervous system, especially in early postmitotic neurons. alpha1-chimaerin mRNA was undetectable before embryonic day 16.5. Adult alpha2-chimaerin mRNA was restricted to neurons within specific brain regions, with highest expression in the entorhinal cortex. alpha2-chimaerin protein localized to neuronal perikarya, dendrites, and axons. The overall pattern of alpha2-chimaerin mRNA expression resembles that of cyclin-dependent kinase regulator p35 (CDK5/p35) which participates in neuronal differentiation and with which chimaerin interacts. To determine whether alpha2-chimaerin may have a role in neuronal differentiation and the relevance of the SH2 domain, the morphological effects of both chimaerin isoforms were investigated in N1E-115 neuroblastoma cells. When plated on poly-lysine, transient alpha2-chimaerin but not alpha1-chimaerin transfectants formed neurites. Permanent alpha2-chimaerin transfectants generated neurites whether or not they were stimulated by serum starvation, and many cells were enlarged. Permanent alpha1-chimaerin transfectants displayed numerous microspikes and contained F-actin clusters, a Cdc42-phenotype, but generated few neurites. In neuroblastoma cells, alpha2-chimaerin was predominantly soluble with some being membrane-associated, whereas alpha1-chimaerin was absent from the cytosol, being membrane- and cytoskeleton-associated, paralleling their subcellular distribution in brain. Transient transfection with alpha2-chimaerin mutated in the SH2 domain (N94H) generated an alpha1-chimaerin-like phenotype, protein partitioned in the particulate fraction, and in NGF-stimulated pheochromocytoma cell line 12 (PC12) cells, neurite formation was inhibited. These results indicate a role for alpha2-chimaerin in morphological differentiation for which its SH2 domain is vital.  (+info)

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. (3/37)

Human n-chimaerin is a GTPase-activating protein (GAP) for p21rac and a phorbol ester receptor. We have isolated rat n-chimaerin cDNA and investigated the cellular and developmental pattern of mRNA expression in the brain. There is extensive sequence conservation with human n-chimaerin in the coding region and the first 400 nucleotides of the 3'-untranslated region (UTR) (90% and 83% identity respectively). The rat cDNA encodes an additional 35 N-terminal amino acids compared with the reported human cDNA, which has a 5'-UTR sequence inversion and a 41-nucleotide deletion including the putative initiator methionine. The rat cDNA encodes a 334-amino acid protein (38200 M(r), pI 8.04) with 97% amino acid sequence identity with the human protein, after correction of the human 5'-DNA sequence. n-Chimaerin mRNA was detectable in embryonic rat brain at day 15 and increased in amount postnatally from birth to 20 days, coincident with cellular differentiation and synaptogenesis. n-Chimaerin mRNA is restricted to neurons, with highest concentrations in hippocampal pyramidal cells, granule cells of the dentate gyrus and cortical neurons. In the cerebellum the mRNA was detected only in Purkinje neurons. The pattern and specificity of mRNA expression suggests an important role for n-chimaerin in neuronal signal-transduction mechanisms.  (+info)

Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. (4/37)

Cyclin-dependent kinase 5 (Cdk5) in association with its neuronal activators p35 and p39 shows a complex involvement in the control of neurocytoskeletal dynamics. Here we show that alpha-chimaerin, a GTPase-activating protein specific for Rac and Cdc42, is a p35-binding protein. The interaction domains of p35 and alpha-chimaerin were delineated. In transfected HeLa cells, p35 and alpha-chimaerin displayed an overlapping distribution pattern and they could be co-immunoprecipitated from the cell lysate. As alpha-chimaerin has a regulatory function in actin repolymerization, these results suggested that the regulation of neurocytoskeleton dynamics by Cdk5 is mediated at least in part via alpha-chimaerin.  (+info)

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (5/37)

Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP)alpha2-chimaerin is involved in Semaphorin 3A (Sema 3A) signaling. In dorsal root ganglion neurons, Sema 3A-induced growth cone collapse was inhibited by alpha2-chimaerin mutated to eliminate GAP activity or interaction with phosphotyrosine. Activation of alpha2-chimaerin by phorbol ester caused growth cone collapse. Active alpha2-chimaerin interacts with collapsin response mediator protein-2 (CRMP-2) and cyclin-dependent kinase (Cdk) 5/p35 kinase through its SH2 and GAP domains, respectively. Cdk5 phosphorylates CRMP-2 at serine 522, possibly facilitating phosphorylation of serine 518 and threonine 514 by glycogen synthase kinase 3beta (GSK3beta), a kinase previously implicated in Sema 3A signaling. Phosphorylation of CRMP-2 serine 522 was essential for Sema 3A-induced growth cone collapse, which is dependent on Cdk5 but not Rho kinase activity. alpha2-chimaerin, like CRMP-2, can associate with the Sema 3A receptor. These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling.  (+info)

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. (6/37)

Abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. The key regulators of cytoskeletal reorganization in dendrites and spines are the Rho GTPases, which modify actin polymerization in response to synaptic signaling. Rho GTPase activity is modulated by multiple regulatory proteins, some of which have been found to associate with proteins localized to spines. Here, we show that the nonkinase phorbol ester receptor alpha1-chimerin is present in dendrites and spines, where it binds to the NMDA receptor NR2A subunit in a phorbol ester-dependent manner. Alpha1-chimerin contains a GTPase activating (GAP) domain, with activity toward the Rho family member Rac1. Overexpression of alpha1-chimerin in cultured hippocampal neurons inhibits formation of new spines and removes existing spines. This reduction in spine density is mediated by Rac1 inhibition, because it depends critically on the presence of a functional GAP domain. Conversely, depletion of alpha1-chimerin leads to an increase in spine density, indicating that a basal inhibition of Rac1 maintains the number of spines at a submaximal level. The ability of alpha1-chimerin to modulate spine number requires an interaction with the NMDA receptor, because an alpha1-chimerin mutant that binds weakly to NR2A fails to decrease spine density. Together, these results suggest that alpha1-chimerin is able to modulate dendritic spine morphology by binding to synaptic NMDA receptors and locally inactivating Rac1.  (+info)

The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. (7/37)

The morphological and functional differentiation of neuronal dendrites is controlled through transcriptional programs and cell-cell signaling. Synaptic activity is thought to play an important role in the maturation of dendritic arbors, but the signaling pathways that couple neuronal activity and morphological changes in dendrites are not well understood. We explored the function of alpha1-chimaerin, a neuronal diacylglycerol-binding protein with a Rho GTPase-activating protein domain that inactivates Rac1. We find that stimulation of phospholipase Cbeta-coupled cell surface receptors recruits alpha1-chimaerin to the plasma membrane of cultured hippocampal neurons. We further show that alpha1-chimaerin protein levels are controlled by synaptic activity and that increased alpha1-chimaerin expression results in the pruning of dendritic spines and branches. This pruning activity requires both the diacylglycerol-binding and Rac GTPase-activating protein activity of alpha1-chimaerin. Suppression of alpha1-chimaerin expression resulted in increased process growth from the dendritic shaft and from spine heads. Our data suggest that alpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors.  (+info)

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding. (8/37)

Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes. DG is produced transiently as it is rapidly metabolized by DG kinase (DGK) to phosphatidic acid. Phorbol esters such as PMA are not metabolized and induced a prolonged membrane association of PKC. Until recently, PKC was the only known phorbol ester receptor. We have shown that a novel brain-specific cDNA, neuronal chimaerin (NC), expressed in Escherichia coli, binds phorbol ester with high affinity, stereospecificity and a phospholipid requirement [Ahmed, Kozma, Monfries, Hall, Lim, Smith & Lim (1990) Biochem. J. 272, 767-773]. The proteins NC, PKC and DGK possess a cysteine-rich domain with the motif HX11/12CX2CXnCX2CX4HX2CX6/7C (where n varies between 12 and 14). The partial motif, CX2CX13CX2C, is present in a number of transcription factors including the steroid hormone receptors and the yeast protein, GAL4, in which zinc plays a structural role of co-ordinating cysteine residues and is essential for DNA binding (protein-nucleic acid interactions). The cysteine-rich domain of NC and PKC is required for phospholipid-dependent phorbol is required for phospholipid-dependent phorbol ester binding, suggesting an involvement of this domain in protein-lipid interactions. We have expressed recombinant NC, PKC and DGK glutathione S-transferase and TrpE fusion proteins in E. coli to investigate the relationship between the cysteine-rich motif, HX11/12CX2CX10-14CX2CX4HX2CX6/7C, zinc and phorbol ester binding. The cysteine-rich domain of NC, PKC and DGK bound 65Zn2+ but only NC and PKC bound [3H]phorbol 12,13-dibutyrate. When NC and PKC were subjected to treatments known to remove metal ions from GAL4 and the human glucocorticoid receptor, phorbol ester binding was inhibited. These data provide evidence for the role of a zinc-dependent structure in phorbol ester binding.  (+info)

β2-chimaerin is a Rac1-specific negative regulator and a candidate tumor suppressor in breast cancer but its precise function in mammary tumorigenesis in vivo is unknown. Here, we study for the first time the role of β2-chimaerin in breast cancer using a mouse model and describe an unforeseen role for this protein in epithelial cell-cell adhesion. We demonstrate that expression of β2-chimaerin in breast cancer epithelial cells reduces E-cadherin protein levels, thus loosening cell-cell contacts. In vivo, genetic ablation of β2-chimaerin in the MMTV-Neu/ErbB2 mice accelerates tumor onset, but delays tumor progression. Finally, analysis of clinical databases revealed an inverse correlation between β2-chimaerin and E-cadherin gene expressions in Her2+ breast tumors. Furthermore, breast cancer patients with low β2-chimaerin expression have reduced relapse free survival but develop metastasis at similar times. Overall, our data redefine the role of β2-chimaerin as tumor suppressor and provide ...
Complete information for CHN2 gene (Protein Coding), Chimerin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CHN1 - CHN1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector shRNA available for purchase from OriGene - Your Gene Company.
Peeesh enenii chn ulaan fan ywlaa shdee,ym bolgoniig n tsugluuldag, enenii achaar hunii nuur gaigui zurchdag bolsn shuu. bas duunuud n ih goy shde,manai huanju geg chn uuruu duuchin shd.Zhao weig suuld Muland toglohod n l harlaa bas hugshirtsun bnlee.uneheer tsarailag huuhen.bas nileen deeh n egch duu 2 zodoontoi kinond togloj bsiin bn ...
سابقه و هدف: زیست پالایی روشی مقرون به صرفه و پاک به منظور تیمار مکان های آلوده است و می تواند منجر به معدنی شدن هیدروکربن ها گردد. میکروب های بومی موجود در منطقه می توانند نقش مؤثری در این رابطه ایفا نمایند. این مطالعه با هدف جداسازی و شناسایی فیلوژنتیکی باکتری های بومی نفت خوار از خاک منطقه کارون اهواز انجام شد. مواد و روش ها: خاک آلوده به نفت منطقه کارون اهواز به صورت تصادفی و در شرایط استریل نمونه برداری شد. مقدار فسفر قابل جذب با استفاده از روش اولسن و مقادیر کربن، هیدروژن و نیتروژن توسط دستگاه CHN meter تعیین گردید. محیط کشت نمک های معدنی حاوی 2 درصد نفت خام به
Uwagi wewn trzne: DIG_030554. http://www.springerlink.com. Brak tytu u czasopisma w bazie ISSN, brak kraju wydawcy (CHN ze znakiem zapytania), skr tu czasopisma. ...
Isolated Duane retraction syndrome is a disorder of eye movement. This condition prevents outward movement of the eye (toward the ear), and in some cases may also limit inward eye movement (toward the nose). As the eye moves inward, the eyelids partially close and the eyeball pulls back (retracts) into its socket. Most commonly, only one eye is affected. About 10 percent of people with isolated Duane retraction syndrome develop amblyopia ("lazy eye"), a condition that causes vision loss in the affected eye.. About 70 percent of all cases of Duane retraction syndrome are isolated, which means they occur without other signs and symptoms. Duane retraction syndrome can also occur as part of syndromes that affect other areas of the body. For example, Duane-radial ray syndrome is characterized by this eye disorder in conjunction with abnormalities of bones in the arms and hands.. Researchers have identified three forms of isolated Duane retraction syndrome, designated types I, II, and III. The types ...
Duane syndrome type 1 is the most common type of Duane syndrome, an eye movement disorder that is present at birth. People with Duane syndrome have restricted ability to move the affected eye(s) outward toward the ear (abduction) and/or inward toward the nose (adduction). The different types are distinguished by the eye movements that are most restricted. Duane syndrome type 1 is characterized by absent to very restricted abduction and normal to mildly restricted adduction. The eye opening (palpebral fissure) narrows and the eyeball retracts into the orbit with adduction. With abduction, the reverse occurs. One or both eyes may be affected. The majority of cases are sporadic (not inherited), while about 10% are familial. 70% of affected people do not have any other abnormalities at birth (isolated Duane syndrome ...
A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction.
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Professor Duane Alwin has been selected by the ASA Council to edit the journal Sociological Methodology, for 2016-2018. For more information please visit the Footnotes website, an ASA publication: http://www.asanet.org/footnotes/julyaugust15/sm_0715.html. ...
Pairs LP StN. Name Nation Rank Points Warm-Up Group 1 1 Wenting WANG / Yan ZHANG CHN 6 49.79 2 Ksenia STOLBOVA / Fedor KLIMOV RUS 5 56.66 3 Cheng PENG / Hao ZHANG CHN 4 57.89 Warm-Up Group 2
Diverse GTPase-activating proteins (GAPs) for the p21rho subfamily were detected by a novel overlay assay (Manser, E., Leung, T., Monfries, C., Teo, M., Hall, C., and Lim, L. (1992) J. Biol. Chem. 267, 16025-16028), with some GAPs being tissue-specific. Using a PCR strategy exploiting conserved regions common to rho/rac-GAPs, we have isolated a rat testis cDNA encoding a 34-kDa rac-GAP termed beta-chimaerin, as it was highly related to n-chimaerin, containing both a GAP domain (77% identity) and the phorbol ester-binding region (93% identity). beta-Chimaerin mRNA is expressed exclusively in the testis at the onset of sexual maturation. In situ hybridization and cell fractionation analyses show beta-chimaerin mRNA expression to be stage-specific, paralleling acrosomal assembly at the late stage of spermatogenesis. A corresponding testis-specific 30-kDa rac-GAP was detected. The testis-specific and stage-dependent expression of this new member of the chimaerin family offer an alternative model system for
By Megan Bungeroth and Alissa Fleck Last week, State Sen. Tom Duane surprised both the political world and his constituents by announcing his intention to retire at the end of his current Senate term. The seven-term Democratic legislator, who represents parts of the Upper West Side as well as Clinton, Hells Kitchen, Chelsea, the West Village, NoHo and Peter Cooper Village and Stuyvesant Town, has been an accomplished advocate for gay rights as well as health care, and plans to focus on continuing his advocacy outside of Albany. "I wanted to do something else and realized its time to start the next chapter," Duane said in a recent interview. "I would say retire is not a completely accurate term; Im just not ready for re-election. I plan to continue working in my own small way to make the world a better place." Duane, who was elected in 1998 and was New Yorks first openly gay senator, was the first senator to introduce the Marriage Equality Act in 2001 and continued to push for its support ...
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Visit Healthgrades for information on Dr. Duane Flannagan, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Visit Healthgrades for information on Dr. Duane Tippets, DO Find Phone & Address information, medical practice history, affiliated hospitals and more.
Connect with Dr. Duane Gels, MD, Allergy and Immunology, Annapolis, MD. Video chat, send a message, ask a text question, or make a virtual appointment on the doctors Virtual Practice on HealthTap.
American reality TV star, Duane Lee Chapman, known as Dog The Bounty Hunter said some wonderful things about his late wife, Beth Chapman who died from stage 2 throat cancer.
Rabbit polyclonal Chimaerin 2 antibody validated for WB and tested in Human and Mouse. Immunogen corresponding to synthetic peptide
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At the risk of sounding unpatriotic, this supposedly debunks the chain-letter (which is only cited but not duplicated in this writeup). What follows is ...
síndrome de Schinzel-Giedion Note Nota The use of the long form of the name, Schinzel-Giedion midface retraction syndrome, is preferred to prevent confusion with Schinzel ulnar-mammary syndrome, a completely unrelated and clinically non-overlapping condition also described by Dr Schinzel. A utilização da forma longa do nome, Schinzel-Giedion Síndrome de retração midface, é o preferido para evitar confusão com Schinzel síndrome ulnar-mamária, completamente independente e clinicamente não-sobreposição condição também descrita pelo Dr. Schinzel. Inheritance Herança Schinzel-Giedion midface retraction syndrome is presumed to be inherited as autosomal recessive on the basis of several pairs of affected sibs with normal parents. Schinzel-Giedion Síndrome de retração midface se presume ser herdada de forma autossômica recessiva, com base em vários pares de irmãos afetados com pais normais. No specific gene or chromosome region has been identified. Nenhum gene específico ou ...
Dusted feature article.Listed: Duane Pitre + Javelin. Every Friday, Dusted Magazine publishes a series of music-related lists determined by our favorite artists. This week: Composer Duane Pitre and ample samplers Tom Van Buskirk and George Langford.
It was minus 49 degrees with the wind-chill this morning. Brrrr. Thats crazy cold. Its not quite to the point where you could throw water into the air and it comes down as ice, but that doesnt feel too far away. Its one of the days your tires feel like squares as you drive to […]. ...
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
Duanes retraction syndrome (DRS) is a complex congenital eye movement disorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons. Studying families with a variant form of the disorder (DURS2-DRS), we have identified causative heterozygous missense mutations in CHN1, a gene on chromosome 2q31 that encodes α2-chimaerin, a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of corticospinal axons in mice. We found that these are gain-of-function mutations that increase α2-chimaerin RacGAP activity in vitro. Several of the mutations appeared to enhance α2-chimaerin translocation to the cell membrane or enhance its ability to self-associate. Expression of mutant α2-chimaerin constructs in chick embryos resulted in failure of oculomotor axons to innervate their target extraocular muscles. We conclude that α2-chimaerin has a critical developmental function in ocular motor axon ...
Duane may refer to: Duane, New York, a US town Duane syndrome, a rare type of strabismus Duane Barry, 29th episode of The X-Files Duane Hopwood, a 2005 film featured in the Sundance Film Festival USCGC Duane (WPG-33), a US Coast Guard cutter and artificial-reef shipwreck Duane (surname), people with the surname Duane Duane (given name), people with the given name Duane ...
Looking for Duane, William John? Find out information about Duane, William John. 1780-1865, U.S. Secretary of Treasury , b. Clonmel, Ireland. He emigrated to Philadelphia with his father, William Duane , and assisted him in publishing... Explanation of Duane, William John
Living a gluten and dairy free lifestyle has its challenges at first, but is certainly worth the effort. Jean Duane, Alternative Cook shares her personal journey.
Dr Duane J Gubler - The meeting place for vaccine professionals from industry, academia, non-profit organizations and government to discuss challenges and successes.
Connect and collaborate with Duane Fonseca at Federal University of Rio Grande, with research interests in Ageing and Crustacea, on Mendeley.
Raising Your Child, Not Your Voice by Duane Cuthbertson starting at $0.99. Raising Your Child, Not Your Voice has 1 available editions to buy at Alibris
Perform reliable PCR with Bio-Rads CHN1 primer pair, for Human. Designed for EvaGreen-based detection with digital PCR (ddPCR).
Kit Component:- KN308260G1, Il1rapl2 gRNA vector 1 in pCas-Guide vector- KN308260G2, Il1rapl2 gRNA vector 2 in pCas-Guide vector- KN308260D, donor…
Duncan is the harder rocker. In the swamp funk "Losing Hand," hes trenchant and biting, a gritty counterpoint to Cipollinas erudite cries. The way the two push and pull each other has the intensity of Duane Allman and Dickey Betts in the Allmans, or the tradeoffs between Allman and Clapton in Derek and the Dominos. Drummer Greg Elmore never hit this hard, and even problematic singer Valenti toes the line ...
He stole your hydrogen peroxide & butter cookies as well. Now your once weekly trip to Duane Reade has to happen twice. Boo hop ...
The suns out and temp has climbed into the 20s. Meaning the snows gonna git heavier. Must stop snow-procrastinating and go out NOW to clear what redrifted and what the city plows re-piled to block access ...
Hi, need to setup a rule for below source - , https://website1.com/prt/sell?yr=73 target -, https://website2.com/chn/hk/dg?yr=73 appreciate any help Thanks in advance ...
Leading final scores: Boys 13-17: 223 - Chou Po-Yueh (TPE) 73 74 76; 231 - Lu Yong-Hao (CHN) 78 81 72; 233 - Huang Jia-Pei (CHN) 76 76 81. Girls 13-17: 241 - Jenny Chang (TPE) 80 77 84; 262 - Peng Yu-Fei (CHN) 88 80 94. Boys 10-12: 229 - Fan Ji-Cheng (CHN) 76 77 76; 246 - Wu Dian-Chao (CHN) 87 80 79; 247 - Li Ye-Xing (CHN) 85 86 76. Girls 10-12: 233 - Zhang Yun-Xuan (HKG) 77 75 81; 234 - Luo Yun-Yi (CHN) 78 77 79; 241 - Sophie Han (HKG) 76 85 80.. About Mission Hills Group. Mission Hills Group, owner and operator of Mission Hills resorts in the heart of the Pearl River Delta and on the tropical island of Hainan, is synonymous with leisure, wellness, entertainment and luxury.. Founded in 1992, Mission Hills is recognized as one of the worlds leading golf brands and a pioneer in Chinas hospitality, sports and leisure industry. The world-class integrated leisure and wellness resort destinations have hosted more than 100 international tournaments, dating back to the World Cup of Golf in 1995, ...
Duane Haberman is General Manager at Stockmens Livestock Market Inc. See Duane Habermans compensation, career history, education, & memberships.
it is not uncommon to find products that disappeared a decade or more ago from supermarket shelves. this, combined with the fact that they blast biblical elevator muzak and christian rock over the intercom has lead me to theorize ...
purpose. The genetic bases of Duanes retraction syndrome (DRS) were investigated to determine its molecular etiologies. In prior studies, the transcription factors SALL4 and HOXA1 were identified as the genes mutated in DRS with radial anomalies, and in DRS with deafness, vascular anomalies, and cognitive deficits, respectively. Less is known, however, about the genetic etiology of DRS when it occurs in isolation, and only one genetic locus for isolated DRS, the DURS2 locus on chromosome 2, has been mapped to date. Toward the goal of identifying the DURS2 gene, two pedigrees have been ascertained that segregate DRS as a dominant trait.. methods. Members of two large dominant DRS pedigrees were enrolled in an ongoing study of the genetic basis of the congenital cranial dysinnervation disorders, and linkage analysis was conducted to determine whether their DRS phenotype maps to the DURS2 locus.. results. By haplotype analysis, the DRS phenotype in each family cosegregates with markers spanning ...
Eye movements depend on correct patterns of connectivity between cranial motor axons and the extraocular muscles. Despite the clinical importance of the ocular motor system, little is known of the molecular mechanisms underlying its development. We have recently shown that mutations in the Chimaerin-1 gene encoding the signaling protein α2-chimaerin (α2-chn) perturb axon guidance in the ocular mot ...
FBI HEADQUARTERS; WASHINGTON, D.C. (Scully is watching the news report.) REPORTER ON TV: ...of the hostages. As you can see, Carl, the SWAT team has taken positions on all the surrounding buildings... (The phone rings and she picks up.) SCULLY: Scully. MULDER: Its me. Im in Virginia. SCULLY: Yeah, I know. Ive been watching it on TV. Whats going on out there? MULDER: Whats the media saying? SCULLY: That an escaped mental patient is holding four people hostage in a travel agency. (Cut to Mulder, who is talking on his cellular phone away from the other agents.) MULDER: Well, what theyre not telling you is that hes former F.B.I. who also claims to be an alien abductee. SCULLY: Seriously? MULDER: Yeah, his names Duane Barry. Look, Scully, I need your help. (Cut to Scully as she boots up her computer.) I need you to find out what happened to him. Anything, transcripts from therapy sessions, hypnotic regressions... (Cut back to Mulder.) Anything about his abduction experience. (The lights ...
Issue No. 1 (Acts & Facts, June/July 1972) contained only news items describing some of our early campus meetings. Specially featured was the meeting held by Dr. Duane Gish on the Davis campus of the University of California. This was the meeting that involved an unscheduled 2.5 hour debate with world-famous evolutionist, G. Ledyard Stebbins. A favorable response from the large student attendance and a very positive write-up in the student paper eventually led to Dr. Gishs famous cartoon booklet, Have You Been Brainwashed? which has been greatly used by the Lord in the past three decades, being distributed in the millions all over the world." From: The Mathematical Impossibility Of Evolution by Henry Morris ...
Read Severance Package by Duane Swierczynski for free with a 30 day free trial. Read unlimited* books and audiobooks on the web, iPad, iPhone and Android.
Duane, I have also found that site insertion is WAY less painful than injections. Plus it is one every 3-4 days instead of 6 injections a day. Amanda ,From: "Duane Jackson" ,email @ redacted, ,Reply-To: email @ redacted ,To: ,email @ redacted, ,Subject: [IP] Re: insulin-pumpers-digest V5 #186 ,Date: Sat, 2 Jun 2001 20:06:59 -0500 , ,Yes the plastic thing ( cannula) is the part that stays in the skin. The ,needle is inside the cannula and is only to introduce the cannula into the ,skin. I have found that the injector that u load the set into is much less ,painful than an injection. ,---------------------------------------------------------- ,for HELP or to subscribe/unsubscribe, contact: [email protected] ,send a DONATION http://www.Insulin-Pumpers.org/donate.shtml ------------------------------------------------------------------------ Get Your Private, Free E-mail from MSN Hotmail at http://www.hotmail.com. ---------------------------------------------------------- for HELP or to ...
Alejandro González Iñárritu (ih-nyar-ee-too), born August 15th, 1963, is a Mexican film director. González Iñárritu is the first Mexican director to be nominated for the Academy Award for Best Director and by the Directors Guild of America for Best Director. He is also the first Mexican-born director to have won the Prix de la mise en scene or best director award at Cannes (2006 ...
Flash ahead I spoke to my brother n regulation and he suggested Related Heating and Air Conditioning! I made Make contact with plus they ended up ready to schedule an appointment in about a week. If the technician (I feel my site Duane) came out he was wonderful ample but additional importantly VERY educated. Duane described every little thing to me and I had a great deal of queries. After the very same regimen he stated the same matter, force is minimal requirements extra refrigerant. I told Duane my story and experienced some Superb explanations as to what experienced took place for the duration of my prior face with another company. The important thing here is Duane has definitely had numerous yrs of palms on practical experience and is aware what he is accomplishing. ...
In March of 1987, young-Earth creationist Dr. Duane Gish came to Washington State University to have a creation-evolution debate with Dr. Grover Krantz, an anthropology professor at WSU. Gishs style in his frequent debates was a rapid-fire overload of facts from a wide variety of fields, most of which were outside of his opponents area…
Antibodies, Bioenergetics, Biology, Biotechnology, Cancer Biology, Cell Biology, Cytokine, Drug Design, Genomics, Microscopy, Molecular Biology, Proteomics, Stem ...
When drugstores go upscale, or at least shiny and new as Duane Reade recently has, somethings going on. Attention must be paid.
Duane matriculated in 1990 from the Glen High School. He studied medicine from 1991 - 1996 at the University of Pretoria and then specialized as an Ear, Nose and Throat Surgeon from 1999 - 2003 at the University of the Free State in Bloemfontein.. Duane is now in private practice in Alberton and focuses mainly on hearing repair surgery and nasal reconstructive surgery. He is an active member of the Johannesburg Cochlear Implant program since 2005 and is one of the surgeons involved in 94.7 "Hear for Life" cochlea implant team.. Duane is married to Therina and they have three daughters, Jodi, Kyra and Leeza. Duane is an accomplished musician (on the drums) and magician and was the South African General Stage Magic Champion in 2002, a title he held for 4 years. ...
Buy OXYGEN THERAPY by DUANE THE GREAT WRITER (Paperback) online at Lulu. Visit the Lulu Marketplace for product details, ratings, and reviews.
Mike Krukow and Duane Kuiper. (it seems wrong to have one without the other): If Dodgers fans can call Vin Scully their favorite, Giants fans can definitely vote for these two. Before the beloved broadcast duo was Kruk and Kuip, they were Duane Kuiper and Mike Krukow-scrappy second baseman and All-Star starting pitcher. And while Krukow had the bigger impact on the team, its worth pointing out that he also out-hit Kuiper in career home runs 5 to 1. Sorry, Kuip.. less ...
Mike Krukow and Duane Kuiper. (it seems wrong to have one without the other): If Dodgers fans can call Vin Scully their favorite, Giants fans can definitely vote for these two. Before the beloved broadcast duo was Kruk and Kuip, they were Duane Kuiper and Mike Krukow-scrappy second baseman and All-Star starting pitcher. And while Krukow had the bigger impact on the team, its worth pointing out that he also out-hit Kuiper in career home runs 5 to 1. Sorry, Kuip.. less ...
1.5$ @ Duane Reade (NY) (delish being a recently squirted duane reeed market brand covering the whole gamut of convenience store- snacks drinks and so on) sweetish liquid, not snapple sweet. CITRICs PUNCH. minor tea taste/feel. tea with citrus flavor ... more like CITRUS water with tea flavor. and now, presenting, the NO ARTIFICIAL COLORS…
Directed by Craig Ross Jr.. With Duane Martin, Vivica A. Fox, Meagan Good, Michael Taliferro. Super fly P. I. gets bad guys the cops cant touch.
Maycock, Robert and Ken Hunt, 2000. In Simon Broughton, and Mark Ellingham, with McConnachie, James and Orla Duane, Ed. 2: patient populations; North America, Caribbean, India, Asia and Pacific.
Orient-que livre efficacité Ifuture à partir de chanteur dans un groupe? Bon! que oui. qui livret doué aux lecteur de grand references et de grande connaissance celles apporter une influence indéniable Iavenir. Ce donné aux lecteur home vrai. Tout va bien! lequel elle contentement de la part de ce journal aller difficile faire dans la vie réelle,mais il est encore donner une bonne idée. Il rend les lecteurs se sentent plaisir et toujours la pensée positive. Ce livre vous donne vraiment une bonne pensée qui va très influencer pour les lecteurs avenir. Comment obtenir ce livre? Obtenir ce livre est simple et facile. On pouvez télécharger le fichier logiciel de ce livre dans ce site Web. Non seulement ce livre intitulé The Amazing Life of Birds: The Twenty-Day Puberty Journal of Duane Hom Par Gary Paulsen vous mettre en conserve également télécharger dautres livres en ligne attirant sur ce site. Ce site est disponible avec des livres rentable et gratuits en ligne. Vous mettre en ...
I appreciate appropriate comments but reserve the right to publish those with credible, verifiable, significant information to contribute to the topic at hand. I will not post comments with commercial content nor those containing personal attacks. Thank You.. ...
Warm-Up Group 1 1 Danielle OBRIEN / Gregory MERRIMAN AUS 10 42.67 2 Maria BOROUNOV / Evgeni BOROUNOV AUS 12 28.52 3 Xueting GUAN / Meng WANG CHN 9 42.77 4 Corenne BRUHNS / Benjamin WESTENBERGER MEX 11 40.68 Warm-Up Group 2 5 Madison CHOCK / Greg ZUERLEIN USA 6 57.14 6 Vanessa CRONE / Paul POIRIER CAN 5 61.66 7 Xintong HUANG / Xun ZHENG CHN 7 52.93
I went in to work this morning, grudgingly. The truth is that I dont MIND working Saturdays but Im also trying to keep a delicate balance right now of my resources... time, energy, money.... Im not allowed to work any over time. Im no longer allowed to work more than 8 hours on any day. But Duane wants me to work Saturdays. So basically... Im in a situation where I need to work six days a week and frankly, I dont know how long I can do that. I have two dr appointments coming up in the next pay period and the only time Im allowed to make up the time is on Saturday so... I guess Ill either be working every Saturday for awhile or Ill have to figure out how to make do on less. ...
After raping a 14-year-old girl, Cody Duane Scott Herrera of Twin Falls will bypass a five to 15-year prison sentence for a program that requires ...
... chimerin 1 MeSH D12.776.402.150.500.460 - neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ... hiv-1 reverse transcriptase MeSH D12.776.964.775.750.320 - fusion proteins, gag-onc MeSH D12.776.964.775.750.320.700 - oncogene ...
... chimerin proteins MeSH D12.776.476.325.150.100.200 -- chimerin 1 MeSH D12.776.476.325.150.300 -- eukaryotic initiation factor-5 ... adp-ribosylation factor 1 MeSH D12.776.476.525.400.025 -- rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp- ... caspase 1 MeSH D12.776.476.075.437.500 -- neuronal apoptosis-inhibitory protein MeSH D12.776.476.075.437.750 -- x-linked ... interferon regulatory factor-1 MeSH D12.776.476.024.389.249 -- interferon regulatory factor-2 MeSH D12.776.476.024.389.374 -- ...
... chimerin proteins MeSH D12.644.360.325.150.100.200 --- chimerin 1 MeSH D12.644.360.325.150.300 --- eukaryotic initiation factor ... map kinase kinase 1 MeSH D12.644.360.440.200 --- map kinase kinase 2 MeSH D12.644.360.440.300 --- map kinase kinase 3 MeSH ... ADP-ribosylation factor 1 MeSH D12.644.360.525.400 --- rab gtp-binding proteins MeSH D12.644.360.525.400.025 --- rab1 gtp- ... interleukin-1 MeSH D12.644.276.174.500.800 --- tumor necrosis factor-alpha MeSH D12.644.276.174.750 --- tumor necrosis factors ...
... is a type of nerve tissue protein. Types include: Chimerin 1 Chimerin 2 Chimerin Proteins at the US National Library ...
... n-chimerin is a protein which in humans is encoded by the CHN1 gene. Chimerin 1 is a GTPase activating protein specific for RAC ... GeneReviews/NCBI/NIH/UW entry on Duane syndrome Chimerin 1 at the US National Library of Medicine Medical Subject Headings ( ... Crystal structure of human chimerin 1 (CHN1)". Hall C, Monfries C, Smith P, Lim HH, Kozma R, Ahmed S, Vanniasingham V, Leung T ... 1754 (1-2): 296-304. doi:10.1016/j.bbapap.2005.07.034. PMID 16202672. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan ...
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... "Entrez Gene: CHN2 chimerin (chimaerin) 2". Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization ... 2005). "Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin". J. Biol. Chem. 280 (26): 24363- ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ...
Chimerin, a type of nerve tissue protein City Hindus Network, a non profit-making organisation that promotes charity, ... CHN may stand for: China's country code People's Republic of China's ISO 3166-1 alpha-3 and IOC country code Republic of ...
1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and ... 43 (1): 107-9. doi:10.1006/geno.1997.4776. PMID 9226381. "Entrez Gene: MYO9B myosin IXB". Bement WM, Hasson T, Wirth JA, et al ...
Agrin Chimerin Proteins Chromogranins Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 ...
Chimerin 2. *Α-シヌクレイン. *CD4. Metadata. This file contains additional information, probably added from the digital camera or ... 13:54, 1 August 2017. 453 × 200 (10.31 MB). Was a bee. {{Information ,Description={{en,1=Ideogram of house mouse (''Mus ...
doi:10.1007/978-1-4615-4869-0_6. PMID 10079839.. *^ a b Benowitz LI, Routtenberg A (1987). "A membrane phosphoprotein ... 22 (1): 239-47. PMID 11756507.. *^ Grasselli G, Mandolesi G, Strata P, Cesare P (June 2011). "Impaired sprouting and axonal ... 317 (1): 219-24. doi:10.1042/bj3170219. PMC 1217466 . PMID 8694767.. *. Kanazir S, Ruzdijic S, Vukosavic S, Ivkovic S, ... doi:10.1016/0896-6273(88)90196-1. PMID 3272162.. *. Ng SC, de la Monte SM, Conboy GL, Karns LR, Fishman MC (Apr 1988). "Cloning ...
They are active or 'ON' when it is bound to GTP and inactive or 'OFF' when bound to GDP.[1] Activation and deactivation of ...
... n-chimerin is a protein which in humans is encoded by the CHN1 gene. Chimerin 1 is a GTPase activating protein specific for RAC ... GeneReviews/NCBI/NIH/UW entry on Duane syndrome Chimerin 1 at the US National Library of Medicine Medical Subject Headings ( ... Crystal structure of human chimerin 1 (CHN1)". Hall C, Monfries C, Smith P, Lim HH, Kozma R, Ahmed S, Vanniasingham V, Leung T ... 1754 (1-2): 296-304. doi:10.1016/j.bbapap.2005.07.034. PMID 16202672. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan ...
... chimerin (chimaerin) 1 ...
Chimerin is a type of nerve tissue protein. Types include: Chimerin 1 Chimerin 2 Chimerin Proteins at the US National Library ...
Chimerin 1. NM_001822. NM_001025201. NM_001206602. Gene Info. CNN3. Calponin 3, acidic. NM_001839. Gene Info. ... Arrestin, beta 1. NM_004041. NM_020251. Gene Info. ASAP1. ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. NM_001247996 ... Thy-1 cell surface antigen. NM_006288. Gene Info. TMED2. Transmembrane emp24 domain trafficking protein 2. NM_006815. Gene Info ... Ras interacting protein 1. NM_017805. Gene Info. RGN. Regucalcin (senescence marker protein-30). NM_152869. NM_004683. Gene ...
Chimerin 1. Protein Coding. 16.22. DISEASES inferred 15 GeneCards inferred via :. DISEASES inferred (show sections) ... The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... SALL4, 1-BP DEL, 1904T deletion. Pathogenic. 6. SALL4 NM_020436.4(SALL4): c.2593C, T (p.Arg865Ter) single nucleotide variant. ... SALL4, 1-BP DEL, 326C deletion. Pathogenic. 10. SALL4 NM_020436.4(SALL4): c.523A, T (p.Lys175Ter) single nucleotide variant. ...
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... "Entrez Gene: CHN2 chimerin (chimaerin) 2". Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization ... 2005). "Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin". J. Biol. Chem. 280 (26): 24363- ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ...
Crystal structure of human chimerin 1 (CHN1). 3eap. Crystal structure of the RhoGAP domain of ARHGAP11A. ... This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which ... Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. ... Inositol polyphosphate 5-phosphatase OCRL-1 (Q01968) (SMART). OMIM:309000: Lowe syndrome. ...
Crystal structure of human chimerin 1 (CHN1). 3eac. Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase ... TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX. 1bfi. SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY ... Crystal structure of human tyrosine phosphatase SHP-1. 2bbu. solution structure of mouse socs3 in complex with a phosphopeptide ... The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T ...
Crystal structure of human chimerin 1 (CHN1). 3ky9. Autoinhibited Vav1. 3pfq. Crystal Structure and Allosteric Activation of ... RAF-1 CYSTEINE RICH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE. 1kbe. Solution structure of the cysteine-rich C1 domain of Kinase ... The Raf-1 CRD is a member of an emerging family of domains, many of which are found within signal transducing proteins. Several ... The Raf-1 protein kinase is the best-characterized downstream effector of activated Ras. Interaction with Ras leads to Raf-1 ...
Bos taurus chimerin (chimaerin) 1 (CHN1), transcript variant 2, mRNA. Assay Type: SYBR® Green Assay Design: Intron-spanning ... Bos taurus chimerin (chimaerin) 1 (CHN1), transcript variant 2, mRNA. Assay Type: Probe Assay Design: Intron-spanning ...
hsa:1123 chimerin 1 K20630 459 168 ( -) 44 0.337 83 -, hsa:342667 SH3 and cysteine rich domain 2 411 168 ( -) 44 0.436 55 -, ... hsa:1124 chimerin 2 K20630 468 174 ( -) 46 0.333 87 -, hsa:10580 sorbin and SH3 domain containing 1 K06086 1292 172 ( -) 45 ... hsa:274 bridging integrator 1 K12562 593 101 ( -) 29 0.328 67 -, [ SSDB , GENES , KEGG2 , KEGG , GenomeNet ] ... hsa:54869 EPS8 like 1 K17277 723 132 ( -) 36 0.351 57 -, hsa:28988 drebrin like K20520 430 131 ( -) 36 0.364 55 -, hsa:30837 ...
chimerin (chimaerin) 1 Aliases:. ARHGAP2, CHN, DURS2, RHOGAP2 RefSeq:. NC_000002.11 NT_005403.17 NG_012642.1 ...
chimerin (chimaerin) 1. NM_030237. 84654. SPZ1. spermatogenic leucine zipper 1. NM_030889. 57537. SORCS2. sortilin-related ...
An important gene associated with Duane Syndrome Type 2 is CHN1 (Chimerin 1). Affiliated tissues include eye. ... The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... 1. CHN1 NM_001822.5(CHN1): c.60A, T (p.Leu20Phe) single nucleotide variant. Pathogenic. rs121912792 GRCh37. Chromosome 2, ... Diseases in the Duane Syndrome Type 1 family:. Duane Syndrome Type 2 Duane Syndrome Type 3 ...
In B16 transplantable mouse melanoma, chimerin overexpression or exogenous injection in the context of its chemokine-like ... Whole genome expression datasets confirmed that chimerin was prognostic of improved outcome in melanoma patients and expression ... A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood (2012) 120(22):4317-23. doi:10.1182 ... The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity (1998) 9(4):555-63. ...
... chimerin 1 MeSH D12.776.402.150.500.460 - neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ... hiv-1 reverse transcriptase MeSH D12.776.964.775.750.320 - fusion proteins, gag-onc MeSH D12.776.964.775.750.320.700 - oncogene ...
... chimerin proteins MeSH D12.776.476.325.150.100.200 -- chimerin 1 MeSH D12.776.476.325.150.300 -- eukaryotic initiation factor-5 ... adp-ribosylation factor 1 MeSH D12.776.476.525.400.025 -- rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp- ... caspase 1 MeSH D12.776.476.075.437.500 -- neuronal apoptosis-inhibitory protein MeSH D12.776.476.075.437.750 -- x-linked ... interferon regulatory factor-1 MeSH D12.776.476.024.389.249 -- interferon regulatory factor-2 MeSH D12.776.476.024.389.374 -- ...
... chimerin proteins MeSH D12.644.360.325.150.100.200 --- chimerin 1 MeSH D12.644.360.325.150.300 --- eukaryotic initiation factor ... map kinase kinase 1 MeSH D12.644.360.440.200 --- map kinase kinase 2 MeSH D12.644.360.440.300 --- map kinase kinase 3 MeSH ... ADP-ribosylation factor 1 MeSH D12.644.360.525.400 --- rab gtp-binding proteins MeSH D12.644.360.525.400.025 --- rab1 gtp- ... interleukin-1 MeSH D12.644.276.174.500.800 --- tumor necrosis factor-alpha MeSH D12.644.276.174.750 --- tumor necrosis factors ...
An important gene associated with Duane Retraction Syndrome is CHN1 (Chimerin 1). Affiliated tissues include heart, skin and t ... The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... 1. CHN1 NM_001822.5(CHN1): c.628-15C, T single nucleotide variant. Uncertain significance. rs529028832 GRCh38. Chromosome 2, ... Duane Retraction Syndrome 1 Duane Retraction Syndrome 2 Diseases related to Duane Retraction Syndrome via text searches within ...
Chimerin (chimaerin) 1 Probe n°212624_s_at Gene Aliases : CHN, ARHGAP2, RHOGAP2. Chromosome Localization : 2q31.1. Gene Number ... 1) Sheng Y et al. - Comparison of different karyotypic chHES-3 cells - GEO - GSE7234 - 2007. (2) Baker DE et al. - Adaptation ... 1) Assou et al. - Unpublished data - - 2005. (2) Golan-Mashiach et al. - Design principle of gene expression used by human - ... 1;293:90 - 2006. (7) Perez-Iratxeta et al. - Study of stem cell function using microarray experiments - FEBS Letters 579:1795 ...
1996) Human myosin IX-b. An unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J ... Amino acid numbering for ankyrin repeats is as follows: 1, G59-S91; 2, S92-E124;3, D125-V157; 4, N158-S189;5, L190-D220; 6, ... 1. N-terminal extension of myr 8a shows eight ankyrin repeat sequences. Alignment of the myr 8a clone 4 sequence with the ... Sequence 1 was generated using a sense primer common to both myr 8a and KIAA0865 with an antisense primer unique to 3′- ...
... and Chimerin (chimaerin) 2 (B-chimaerin), activated by 1,2-diacyl-glycerol (DAG) [23]. Rho GTPase-activating proteins are also ... Main GAPs for CDC42 are Deleted in liver cancer 1 (RHG7) [17], Rho GTPase activating protein 17 (Rich1) [18], CDC42 GTPase- ... Among known GEFs for CDC42 are FYVE, RhoGEF and PH domain containing 1 and 4 (FGD1, Frabin) [5], [6], Epithelial cell ... The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. The Journal of ...
Chimerin 1. Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) ...
Regulation of chimerin proteins occurs in response to growth factor receptor or G-protein coupled receptor activation followed ... Monoclonal Antibody - β2-Chimerin (2E3) Rat mAb - Western Blotting, UniProt ID P52757, Entrez ID 1124 #4728 ... β2-chimerin is also down-regulated in breast cancer, and its expression causes GAP activity-dependent cell cycle arrest in MCF- ... β2-chimerin is highly expressed in brain and pancreas, and its expression is down-regulated in malignant gliomas (3). ...
1. a. An organism, organ, or part consisting of two or more tissues of different genetic composition, produced as a result of ... 1. The individual produced by grafting an embryonic part of one animal onto the embryo of another, either of the same or of ... As expected, harboring at least one In2G mutation (as in chimeras CH-1, CH-2, CH-3, CH-5, CH-6, and the newly identified CH-8) ... 1. In experimental embryology, the individual produced by grafting an embryonic part of one animal onto the embryo of another, ...
  • In principle, the in vitro differentiation of neurosphere-forming cells includes five steps: (1) cessation of proliferation, (2) attachment of the neurosphere, (3) detachment of cells from the neurosphere cell cluster, (4) migration of these cells away from the sphere, and (5) their actual differentiation into different cell types. (jneurosci.org)
  • Because molecular motor proteins have been implicated in a wide spectrum of processes associated with cell motility, we initiated studies to define the pool of myosins in migrating cerebellar granule neurons and type-1 neocortical astrocytes. (jneurosci.org)
  • Although stem cell properties have been characterized in many tissues ( 1 ), we are only beginning to understand how stem cell function is regulated at the molecular level. (sciencemag.org)
  • GeneReviews/NCBI/NIH/UW entry on Duane syndrome Chimerin 1 at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • Sevilla, Santos, Vega, Lazo: Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. (anticorps-enligne.fr)
  • In direct ELISAs, less than 1 % cross-reactivity with recombinant human (rh) CXCL16, rhFractalkine, recombinant mouse Fractalkine, and recombinant rat Fractalkine is observed. (antibodies-online.com)
  • 1. an organism with different cell populations derived from different zygotes of the same or different species, occurring spontaneously or produced artificially. (thefreedictionary.com)
  • To further elucidate the role of myosins in the process of neuronal cell migration, we initiated studies to define the pool of myosins in migrating cerebellar granule neurons and type-1 neocortical astrocytes. (jneurosci.org)
  • cadherin 2, type 1, N-cadherin (neuro. (broadinstitute.org)
  • Instillation of 1% pilocarpine hydrochloride into the eye shrank the pupil by 80% in wild-type mice, whereas miffy mice exhibited less than 40% shrinking of the pupil. (jnss.org)
  • This is instigated either by complete lack of insulin production (type 1 diabetes), reduced level of insulin production (type 2 diabetes) or insulin resistance (inability of body cells to take up glucose). (geneticsmr.org)
  • Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients. (nih.gov)
  • We used a two-stage study design to evaluate whether variations in the peroxisome proliferator-activated receptors (PPAR) and the PPAR gamma co-activator 1 (PGC1) gene families (PPARA, PPARG, PPARD, PPARGC1A, and PPARGC1B) are associated with type 2 diabetes (T2D) risk. (jove.com)