A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal transduction. The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.
A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.
Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.
A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 3.6.1.47.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. (1/37)

Macrophages respond to Gram-negative bacterial pathogens by phagocytosis and pro-inflammatory gene expression. These responses may require GTPases that have been implicated in cytoskeletal alterations and activation of NF-kappaB. To determine the role of Rac1 and Cdc42 in signal transduction events triggered by Pseudomonas aeruginosa, we expressed GTP binding-deficient alleles of Rac1 or Cdc42, or Chim-GAP, a Rac1/Cdc42-specific GTPase-activating protein domain, in a subline of RAW 264.7 cells, and challenged the transfected cells with a laboratory strain of P. aeruginosa, PAO1. Expression of Rac1 N17, Cdc42 N17, or Chim-GAP led to a marked reduction of phagocytosis. In contrast, nuclear translocation of p65 NF-kappaB was unaffected by expression of the same constructs. Incubation of macrophages with PAO1 led to NF-kappaB-dependent expression of inducible nitric-oxide synthase, COX-2, and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function. Isogenic strains of PAO1 that lacked surface adhesins were poorly ingested; however, they induced pro-inflammatory gene expression with an efficiency equal to that of PAO1. These results indicate that the signal transduction events leading to phagocytosis and pro-inflammatory protein expression are distinct. Rac1 and Cdc42 serve as effectors of phagocytosis, but not NF-kappaB-dependent gene expression, in the macrophage response to P. aeruginosa.  (+info)

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. (2/37)

Neuronal differentiation involves Rac and Cdc42 GTPases. alpha-Chimaerin, a Rac/Cdc42 regulator, occurs as alpha1- and alternatively spliced Src homology 2 (SH2) domain-containing alpha2-isoforms. alpha2-chimaerin mRNA was highly expressed in the rat embryonic nervous system, especially in early postmitotic neurons. alpha1-chimaerin mRNA was undetectable before embryonic day 16.5. Adult alpha2-chimaerin mRNA was restricted to neurons within specific brain regions, with highest expression in the entorhinal cortex. alpha2-chimaerin protein localized to neuronal perikarya, dendrites, and axons. The overall pattern of alpha2-chimaerin mRNA expression resembles that of cyclin-dependent kinase regulator p35 (CDK5/p35) which participates in neuronal differentiation and with which chimaerin interacts. To determine whether alpha2-chimaerin may have a role in neuronal differentiation and the relevance of the SH2 domain, the morphological effects of both chimaerin isoforms were investigated in N1E-115 neuroblastoma cells. When plated on poly-lysine, transient alpha2-chimaerin but not alpha1-chimaerin transfectants formed neurites. Permanent alpha2-chimaerin transfectants generated neurites whether or not they were stimulated by serum starvation, and many cells were enlarged. Permanent alpha1-chimaerin transfectants displayed numerous microspikes and contained F-actin clusters, a Cdc42-phenotype, but generated few neurites. In neuroblastoma cells, alpha2-chimaerin was predominantly soluble with some being membrane-associated, whereas alpha1-chimaerin was absent from the cytosol, being membrane- and cytoskeleton-associated, paralleling their subcellular distribution in brain. Transient transfection with alpha2-chimaerin mutated in the SH2 domain (N94H) generated an alpha1-chimaerin-like phenotype, protein partitioned in the particulate fraction, and in NGF-stimulated pheochromocytoma cell line 12 (PC12) cells, neurite formation was inhibited. These results indicate a role for alpha2-chimaerin in morphological differentiation for which its SH2 domain is vital.  (+info)

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. (3/37)

Human n-chimaerin is a GTPase-activating protein (GAP) for p21rac and a phorbol ester receptor. We have isolated rat n-chimaerin cDNA and investigated the cellular and developmental pattern of mRNA expression in the brain. There is extensive sequence conservation with human n-chimaerin in the coding region and the first 400 nucleotides of the 3'-untranslated region (UTR) (90% and 83% identity respectively). The rat cDNA encodes an additional 35 N-terminal amino acids compared with the reported human cDNA, which has a 5'-UTR sequence inversion and a 41-nucleotide deletion including the putative initiator methionine. The rat cDNA encodes a 334-amino acid protein (38200 M(r), pI 8.04) with 97% amino acid sequence identity with the human protein, after correction of the human 5'-DNA sequence. n-Chimaerin mRNA was detectable in embryonic rat brain at day 15 and increased in amount postnatally from birth to 20 days, coincident with cellular differentiation and synaptogenesis. n-Chimaerin mRNA is restricted to neurons, with highest concentrations in hippocampal pyramidal cells, granule cells of the dentate gyrus and cortical neurons. In the cerebellum the mRNA was detected only in Purkinje neurons. The pattern and specificity of mRNA expression suggests an important role for n-chimaerin in neuronal signal-transduction mechanisms.  (+info)

Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. (4/37)

Cyclin-dependent kinase 5 (Cdk5) in association with its neuronal activators p35 and p39 shows a complex involvement in the control of neurocytoskeletal dynamics. Here we show that alpha-chimaerin, a GTPase-activating protein specific for Rac and Cdc42, is a p35-binding protein. The interaction domains of p35 and alpha-chimaerin were delineated. In transfected HeLa cells, p35 and alpha-chimaerin displayed an overlapping distribution pattern and they could be co-immunoprecipitated from the cell lysate. As alpha-chimaerin has a regulatory function in actin repolymerization, these results suggested that the regulation of neurocytoskeleton dynamics by Cdk5 is mediated at least in part via alpha-chimaerin.  (+info)

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (5/37)

Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP)alpha2-chimaerin is involved in Semaphorin 3A (Sema 3A) signaling. In dorsal root ganglion neurons, Sema 3A-induced growth cone collapse was inhibited by alpha2-chimaerin mutated to eliminate GAP activity or interaction with phosphotyrosine. Activation of alpha2-chimaerin by phorbol ester caused growth cone collapse. Active alpha2-chimaerin interacts with collapsin response mediator protein-2 (CRMP-2) and cyclin-dependent kinase (Cdk) 5/p35 kinase through its SH2 and GAP domains, respectively. Cdk5 phosphorylates CRMP-2 at serine 522, possibly facilitating phosphorylation of serine 518 and threonine 514 by glycogen synthase kinase 3beta (GSK3beta), a kinase previously implicated in Sema 3A signaling. Phosphorylation of CRMP-2 serine 522 was essential for Sema 3A-induced growth cone collapse, which is dependent on Cdk5 but not Rho kinase activity. alpha2-chimaerin, like CRMP-2, can associate with the Sema 3A receptor. These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling.  (+info)

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. (6/37)

Abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. The key regulators of cytoskeletal reorganization in dendrites and spines are the Rho GTPases, which modify actin polymerization in response to synaptic signaling. Rho GTPase activity is modulated by multiple regulatory proteins, some of which have been found to associate with proteins localized to spines. Here, we show that the nonkinase phorbol ester receptor alpha1-chimerin is present in dendrites and spines, where it binds to the NMDA receptor NR2A subunit in a phorbol ester-dependent manner. Alpha1-chimerin contains a GTPase activating (GAP) domain, with activity toward the Rho family member Rac1. Overexpression of alpha1-chimerin in cultured hippocampal neurons inhibits formation of new spines and removes existing spines. This reduction in spine density is mediated by Rac1 inhibition, because it depends critically on the presence of a functional GAP domain. Conversely, depletion of alpha1-chimerin leads to an increase in spine density, indicating that a basal inhibition of Rac1 maintains the number of spines at a submaximal level. The ability of alpha1-chimerin to modulate spine number requires an interaction with the NMDA receptor, because an alpha1-chimerin mutant that binds weakly to NR2A fails to decrease spine density. Together, these results suggest that alpha1-chimerin is able to modulate dendritic spine morphology by binding to synaptic NMDA receptors and locally inactivating Rac1.  (+info)

The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. (7/37)

The morphological and functional differentiation of neuronal dendrites is controlled through transcriptional programs and cell-cell signaling. Synaptic activity is thought to play an important role in the maturation of dendritic arbors, but the signaling pathways that couple neuronal activity and morphological changes in dendrites are not well understood. We explored the function of alpha1-chimaerin, a neuronal diacylglycerol-binding protein with a Rho GTPase-activating protein domain that inactivates Rac1. We find that stimulation of phospholipase Cbeta-coupled cell surface receptors recruits alpha1-chimaerin to the plasma membrane of cultured hippocampal neurons. We further show that alpha1-chimaerin protein levels are controlled by synaptic activity and that increased alpha1-chimaerin expression results in the pruning of dendritic spines and branches. This pruning activity requires both the diacylglycerol-binding and Rac GTPase-activating protein activity of alpha1-chimaerin. Suppression of alpha1-chimaerin expression resulted in increased process growth from the dendritic shaft and from spine heads. Our data suggest that alpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors.  (+info)

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding. (8/37)

Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes. DG is produced transiently as it is rapidly metabolized by DG kinase (DGK) to phosphatidic acid. Phorbol esters such as PMA are not metabolized and induced a prolonged membrane association of PKC. Until recently, PKC was the only known phorbol ester receptor. We have shown that a novel brain-specific cDNA, neuronal chimaerin (NC), expressed in Escherichia coli, binds phorbol ester with high affinity, stereospecificity and a phospholipid requirement [Ahmed, Kozma, Monfries, Hall, Lim, Smith & Lim (1990) Biochem. J. 272, 767-773]. The proteins NC, PKC and DGK possess a cysteine-rich domain with the motif HX11/12CX2CXnCX2CX4HX2CX6/7C (where n varies between 12 and 14). The partial motif, CX2CX13CX2C, is present in a number of transcription factors including the steroid hormone receptors and the yeast protein, GAL4, in which zinc plays a structural role of co-ordinating cysteine residues and is essential for DNA binding (protein-nucleic acid interactions). The cysteine-rich domain of NC and PKC is required for phospholipid-dependent phorbol is required for phospholipid-dependent phorbol ester binding, suggesting an involvement of this domain in protein-lipid interactions. We have expressed recombinant NC, PKC and DGK glutathione S-transferase and TrpE fusion proteins in E. coli to investigate the relationship between the cysteine-rich motif, HX11/12CX2CX10-14CX2CX4HX2CX6/7C, zinc and phorbol ester binding. The cysteine-rich domain of NC, PKC and DGK bound 65Zn2+ but only NC and PKC bound [3H]phorbol 12,13-dibutyrate. When NC and PKC were subjected to treatments known to remove metal ions from GAL4 and the human glucocorticoid receptor, phorbol ester binding was inhibited. These data provide evidence for the role of a zinc-dependent structure in phorbol ester binding.  (+info)

... n-chimerin is a protein which in humans is encoded by the CHN1 gene. Chimerin 1 is a GTPase activating protein specific for RAC ... GeneReviews/NCBI/NIH/UW entry on Duane syndrome Chimerin+1 at the US National Library of Medicine Medical Subject Headings ( ... Crystal structure of human chimerin 1 (CHN1)". Hall C, Monfries C, Smith P, Lim HH, Kozma R, Ahmed S, Vanniasingham V, Leung T ... 1754 (1-2): 296-304. doi:10.1016/j.bbapap.2005.07.034. PMID 16202672. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan ...
α2-Chimerin acts in a similar manner to α1-Chimerin, but is primarily found in the brain and testes. It is also an SH2 ... β2-chimerin has been shown to play a role in breast cancer. In breast cancer cells the amount of β2-chimerin messengers are ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... Mutations found in α-chi-merin lead to the Duane retraction syndrome 2. Beta-chimerin (Rho GTPase-activating protein 3, 468aa) ...
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain ... "Entrez Gene: CHN2 chimerin (chimaerin) 2". Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization ... 2005). "Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin". J. Biol. Chem. 280 (26): 24363- ... 2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with ...
In some families the condition is associated with variants in the Chimerin 1 gene and in others it is associated with variants ...
... chimerin 1 MeSH D12.776.402.150.500.460 - neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH ... neuregulin-1 See List of MeSH codes (D12.776.476). MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280. ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ...
... chimerin proteins MeSH D12.776.476.325.150.100.200 - chimerin 1 MeSH D12.776.476.325.150.300 - eukaryotic initiation factor-5 ... adp-ribosylation factor 1 MeSH D12.776.476.525.400.025 - rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 - rab2 gtp- ... caspase 1 MeSH D12.776.476.075.437.500 - neuronal apoptosis-inhibitory protein MeSH D12.776.476.075.437.750 - x-linked ... interferon regulatory factor-1 MeSH D12.776.476.024.389.249 - interferon regulatory factor-2 MeSH D12.776.476.024.389.374 - ...
... chimerin proteins MeSH D12.644.360.325.150.100.200 - chimerin 1 MeSH D12.644.360.325.150.300 - eukaryotic initiation factor-5 ... map kinase kinase 1 MeSH D12.644.360.440.200 - map kinase kinase 2 MeSH D12.644.360.440.300 - map kinase kinase 3 MeSH D12.644. ... ADP-ribosylation factor 1 MeSH D12.644.360.525.400 - rab gtp-binding proteins MeSH D12.644.360.525.400.025 - rab1 gtp-binding ... interleukin-1 MeSH D12.644.276.174.500.800 - tumor necrosis factor-alpha MeSH D12.644.276.174.750 - tumor necrosis factors MeSH ...
1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and ... 43 (1): 107-9. doi:10.1006/geno.1997.4776. PMID 9226381. "Entrez Gene: MYO9B myosin IXB". Bement WM, Hasson T, Wirth JA, et al ...
According to the CEO Lawrence Chimerin, the term "econometrics" was dropped, because the consolidated company would broaden its ... April 1, 1987: WEF Associates AG, the parent of Wharton Econometric Forecasting Associates, announced that it acquired Chase ...
Agrin Chimerin Proteins Chromogranins Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 ... 1600 (1-2): 138-47. doi:10.1016/S1570-9639(02)00454-5. PMID 12445469. (All articles with unsourced statements, Articles with ...
Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing ... Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007 Aug ... of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol Cell Biol. 1993 Aug;13(8):4986-98. doi ...
Chimerin 1 D12.776.402.150.100.200 Chimerin Proteins D12.776.402.150.100 Chive J2.500.850.243 Chloracne C17.800.271.125.800 ... HIV-1 B4.909.777.731.589.650.350.400 HIV-2 B4.909.777.731.589.650.350.410 HMG-Box Domains G2.111.570.790.709.610.380 G2.111. ... Mucin-1 D23.101.840.75.300 D23.101.140.75.300 Mud Therapy E2.779.249.610 Multicenter Studies as Topic E5.318.760.535.500 E5.318 ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase D8.811.682.690.708.783.400 4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529. ...
alpha-Chimerin alpha1 Chimaerin alpha1-Chimaerin arhGAP2 Protein n Chimaerin n-Chimaerin n-Chimerin rhoGAP2 Protein ... alpha-Chimerin. alpha1 Chimaerin. alpha1-Chimaerin. arhGAP2 Protein. n Chimaerin. n-Chimaerin. n-Chimerin. rhoGAP2 Protein. ... alpha 2 Chimerin. alpha Chimaerin. alpha Chimerin. alpha-1 Chimaerin. alpha-1 Chimerin. alpha-2 Chimaerin. alpha-2 Chimerin. ... Chimerin, alpha-2 alpha 2 Chimaerin alpha 2 Chimerin alpha-2 Chimaerin ...
Chimerin 1 D12.776.402.150.100.200 Chimerin Proteins D12.776.402.150.100 Chive J2.500.850.243 Chloracne C17.800.271.125.800 ... HIV-1 B4.909.777.731.589.650.350.400 HIV-2 B4.909.777.731.589.650.350.410 HMG-Box Domains G2.111.570.790.709.610.380 G2.111. ... Mucin-1 D23.101.840.75.300 D23.101.140.75.300 Mud Therapy E2.779.249.610 Multicenter Studies as Topic E5.318.760.535.500 E5.318 ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase D8.811.682.690.708.783.400 4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529. ...
Chimerin Proteins D12.776.641.124 D12.776.631.124 Chive B1.650.940.800.575.100.610.100.149 B1.650.940.800.575.100.99.50.60.149 ... 8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633.100.759.138.50 2- ... 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide ... Ataxin-1 D12.776.641.69.500 D12.776.631.69.500 Ataxin-10 D12.776.641.69.950 D12.776.631.69.950 Ataxin-2 D12.776.641.69.750 ...
Chimerin 1 D12.776.402.150.100.200 Chimerin Proteins D12.776.402.150.100 Chive J2.500.850.243 Chloracne C17.800.271.125.800 ... HIV-1 B4.909.777.731.589.650.350.400 HIV-2 B4.909.777.731.589.650.350.410 HMG-Box Domains G2.111.570.790.709.610.380 G2.111. ... Mucin-1 D23.101.840.75.300 D23.101.140.75.300 Mud Therapy E2.779.249.610 Multicenter Studies as Topic E5.318.760.535.500 E5.318 ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase D8.811.682.690.708.783.400 4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529. ...
Ophthalmic and physical examinations, as well as genetic screenings for variants in chimerin 1 (CHN1), were performed for all ... 1. A novel nonsense variant (c.1499C>G) in CRB1 caused Leber congenital amaurosis-8 in a Chinese family and a literature review ... In this study, we explored the variant in the Crumbs homologue 1 (CRB1) gene in a Chinese family with LCA. METHODS: We ... Clinical study of intermittent use of 1% atropine on retardation of myopia progression in Chinese school children / 中国学校卫生 ...
ChimeRin KitPvP MCDLSPOT Aug 24, 2021 0 969 Kacpya Kit PVP MCDLSPOT Aug 4, 2021 4 1985 ... The #1 PvP Texture Pack For 2021! (1.17+) FPS BOOST (Minecraft... MCDLSPOT Nov 16, 2021 0 3907 ...
ChimeRin KitPvP MCDLPIT Aug 24, 2021 0 464 Kacpya Kit PVP MCDLPIT Aug 4, 2021 4 1586 ...
chimerin 2 [Source:HGNC Symbol;Acc.... CISH. 1154. CISH. cytokine inducible SH2 containing .... ... ONDER_CDH1_TARGETS_1_UP ONDER_CDH1_TARGETS_2_DN ONDER_CDH1_TARGETS_2_UP ONDER_CDH1_TARGETS_3_DN ONDER_CDH1_TARGETS_3_UP P53_DN. ... cadherin 1 [Source:HGNC Symbol;Acc.... CHN2. 1124. CHN2. ... copine 1 [Source:HGNC Symbol;Acc:H.... CREM. 1390. CREM. cAMP ...
Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic ...
3 (5): 1-10. doi:10.12715/har.2014.3.5.. *↑ Strunk A, Bhalla V, Clopton P, Nowak RM, McCord J, Hollander JE, Duc P, Storrow AB ... 119 (1): S127. doi:10.1016/j.jaci.2006.11.482.. *↑ Clerico A, Zaninotto M, Prontera C, Giovannini S, Ndreu R, Franzini M, ... 365 (1): 32-43. doi:10.1056/NEJMoa1100171. PMID 21732835.. *↑ McMurray, John J.V.; Packer, Milton; Desai, Akshay S.; Gong, ... 1 (4): 258-64. doi:10.1161/CIRCHEARTFAILURE.108.790774. PMID 19808300.. *↑ Semenov AG, Postnikov AB, Tamm NN, Seferian KR, ...
Gene Name : chimerin 2. GTEx V8 NCBI GeneID : 1124. NCBI : NM_004067.4. NCBI : NP_004058.1. ...
... alpha-chimerin[TIAB]) OR (ARHGAP2[TIAB]) OR (DURS2[TIAB]) OR (n-chimerin[TIAB]) OR (N-chimaerin[TIAB])) AND ((Genes[MH]) OR ( ... alpha-chimerin[TIAB]) OR (ARHGAP2[TIAB]) OR (DURS2[TIAB]) OR (n-chimerin[TIAB]) OR (N-chimaerin[TIAB])) AND ((Genes[MH]) OR ( ... Ophthalmic and physical examinations, as well as genetic screenings for variants in chimerin 1 (CHN1), were performed for all ... Ophthalmic and physical examinations, as well as genetic screenings for variants in chimerin 1 (CHN1), were performed f … ...
Chimerin Proteins. Chimerin 1. EIF-2B. GTP Phosphohydrolase Activators. GTP Phosphohydrolase-Linked Elongation Factors GTP ... Peptide Elongation Factor 1 Peptide Elongation Factor 2 p120 GTPase Activating Protein rab GTP-Binding Proteins. rab1 GTP- ...
All identified pathogenic variants are gain-of-function variants that increase N-chimaerin (α2-chimerin RacGAP) activity. ... 1 c.378T,G. p.Ile126Met. Segregated w/disease but also found at low frequency in the population [Miyake et al 2008, Chan et al ... 1. The eye findings are more likely to be bilateral in familial cases and in those in whom a pathogenic variant is identified ... Type II (~1%-5%). Type III (~10%-20%). Abduction Absent to markedly restricted. Normal to mildly restricted. Absent to markedly ...
alpha-2 Chimerin alpha-Chimaerin alpha-Chimerin alpha1-Chimaerin arhGAP2 Protein n-Chimaerin n-Chimerin rhoGAP2 Protein ... alpha-2 Chimerin Narrower Concept UI. M0331682. Registry Number. 0. Terms. alpha-2 Chimerin Preferred Term Term UI T362076. ... alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.. Terms. Chimerin 1 ... Chimerin 1 Preferred Concept UI. M0328168. Registry Number. 0. Scope Note. A GTPase activating protein that is specific for RAC ...
Chimerin Proteins D12.776.641.124 D12.776.631.124 Chive B1.650.940.800.575.100.610.100.149 B1.650.940.800.575.100.99.50.60.149 ... 8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633.100.759.138.50 2- ... 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide ... Ataxin-1 D12.776.641.69.500 D12.776.631.69.500 Ataxin-10 D12.776.641.69.950 D12.776.631.69.950 Ataxin-2 D12.776.641.69.750 ...
alpha-2 Chimerin alpha-Chimaerin alpha-Chimerin alpha1-Chimaerin arhGAP2 Protein n-Chimaerin n-Chimerin rhoGAP2 Protein ... alpha-2 Chimerin Narrower Concept UI. M0331682. Registry Number. 0. Terms. alpha-2 Chimerin Preferred Term Term UI T362076. ... alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes.. Terms. Chimerin 1 ... Chimerin 1 Preferred Concept UI. M0328168. Registry Number. 0. Scope Note. A GTPase activating protein that is specific for RAC ...
14-3-3 Proteins N0000170458 Smad Proteins N0000170502 GTPase-Activating Proteins N0000170503 RGS Proteins N0000170508 Chimerin ... 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- N0000175328 beta 2-Glycoprotein I N0000169400 beta 2-Microglobulin ... Member 1 N0000180212 Nuclear Receptor Subfamily 1, Group F, Member 1 N0000180275 Nuclear Receptor Subfamily 1, Group F, Member ... Member 1 N0000180286 Nuclear Receptor Subfamily 2, Group C, Member 2 N0000180203 Nuclear Receptor Subfamily 4, Group A, Member ...
Chimerin 1 D12.776.402.150.100.200 Chimerin Proteins D12.776.402.150.100 Chive J2.500.850.243 Chloracne C17.800.271.125.800 ... HIV-1 B4.909.777.731.589.650.350.400 HIV-2 B4.909.777.731.589.650.350.410 HMG-Box Domains G2.111.570.790.709.610.380 G2.111. ... Mucin-1 D23.101.840.75.300 D23.101.140.75.300 Mud Therapy E2.779.249.610 Multicenter Studies as Topic E5.318.760.535.500 E5.318 ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase D8.811.682.690.708.783.400 4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529. ...
Chimerin 1 D12.776.402.150.100.200 Chimerin Proteins D12.776.402.150.100 Chive J2.500.850.243 Chloracne C17.800.271.125.800 ... HIV-1 B4.909.777.731.589.650.350.400 HIV-2 B4.909.777.731.589.650.350.410 HMG-Box Domains G2.111.570.790.709.610.380 G2.111. ... Mucin-1 D23.101.840.75.300 D23.101.140.75.300 Mud Therapy E2.779.249.610 Multicenter Studies as Topic E5.318.760.535.500 E5.318 ... 25-Hydroxyvitamin D3 1-alpha-Hydroxylase D8.811.682.690.708.783.400 4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529. ...
Chimerin Proteins D12.776.641.124 D12.776.631.124 Chive B1.650.940.800.575.100.610.100.149 B1.650.940.800.575.100.99.50.60.149 ... 8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633.100.759.138.50 2- ... 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide ... Ataxin-1 D12.776.641.69.500 D12.776.631.69.500 Ataxin-10 D12.776.641.69.950 D12.776.631.69.950 Ataxin-2 D12.776.641.69.750 ...
Chimerin Proteins D12.776.641.124 D12.776.631.124 Chive B1.650.940.800.575.100.610.100.149 B1.650.940.800.575.100.99.50.60.149 ... 8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633.100.759.138.50 2- ... 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide ... Ataxin-1 D12.776.641.69.500 D12.776.631.69.500 Ataxin-10 D12.776.641.69.950 D12.776.631.69.950 Ataxin-2 D12.776.641.69.750 ...
... chimerin 1,gngm tiul1,tiul1,C1538115,tgif-interacting ubiquitin ligase 1,gngm left hamate bone,leave hamate bone,C0817294,left ... beta chimerin,gngm articular capsule of sternoclavicular joint,articular capsule of sternoclavicular joint,C0818555,fibrous ... loui , ex2-8dup,C1847048,ldlr, ex2-8dup,gngm c-type lectin-like 1,c-type lectin-like 1,C1843833,clecl1,gngm left peribronchial ... 1-bp in , 989a,C1865561,cftr, 1-bp ins, 989a,gngm right sixth rib neck,right sixth rib neck,C0502944,right sixth rib neck,bpoc ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
CHIMERIN 1 QUIMERINA 1 QUINASES DE PROTEÍNA QUINASE ATIVADA POR MITÓGENO MITOGEN-ACTIVATED PROTEIN KINASE KINASES QUINASAS ... PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ...
... chimerin 1,gngm tiul1,tiul1,C1538115,tgif-interacting ubiquitin ligase 1,gngm left hamate bone,leave hamate bone,C0817294,left ... beta chimerin,gngm articular capsule of sternoclavicular joint,articular capsule of sternoclavicular joint,C0818555,fibrous ... loui , ex2-8dup,C1847048,ldlr, ex2-8dup,gngm c-type lectin-like 1,c-type lectin-like 1,C1843833,clecl1,gngm left peribronchial ... 1-bp in , 989a,C1865561,cftr, 1-bp ins, 989a,gngm right sixth rib neck,right sixth rib neck,C0502944,right sixth rib neck,bpoc ...
Chimerin Proteins/genetics*; Chimerin Proteins/metabolism*; Chlorocebus aethiops; Diglycerides/metabolism; Exons/genetics; Gene ...
  • Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. (medlineplus.gov)
  • We aimed to investigate the effect of miR-192-5p on cell proliferation, migration and angiogenesis in DR. METHODS: Expression of miR-192-5p, ELAV-like RNA binding protein 1 (ELAVL1) and phosphoinositide 3-kinase delta (PI3Kδ) in human retinal fibrovascular membrane (FVM) samples and human retinal microvascular endothelial cells (HRMECs) was assessed using RT-qPCR. (bvsalud.org)
  • The alternatively spliced form of CHIMERIN 1 (alpha-2 Chimerin) contains an additional src homology domain and is expressed in both the brain and testes. (nih.gov)