An individual that contains cell populations derived from different zygotes.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins produced from GENES that have mutated by the fusing of protein coding regions of more than one gene. Such hybrid proteins are responsible for some instances of ANTIBIOTIC RESISTANCE and defective biological processes such as NEOPLASMS.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Established cell cultures that have the potential to propagate indefinitely.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Proteins prepared by recombinant DNA technology.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The rate dynamics in chemical or physical systems.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The major group of transplantation antigens in the mouse.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The use of DNA recombination (RECOMBINATION, GENETIC) to prepare a large gene library of novel, chimeric genes from a population of randomly fragmented DNA from related gene sequences.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
A purinergic P2X neurotransmitter receptor found at sympathetically innervated SMOOTH MUSCLE. It may play a functional role regulating the juxtoglomerular apparatus of the KIDNEY.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
A layer of cells lining the fluid-filled cavity (blastocele) of a BLASTULA, usually developed from a fertilized insect, reptilian, or avian egg.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
A unisexual reproduction without the fusion of a male and a female gamete (FERTILIZATION). In parthenogenesis, an individual is formed from an unfertilized OVUM that did not complete MEIOSIS. Parthenogenesis occurs in nature and can be artificially induced.
The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
Deletion of sequences of nucleic acids from the genetic material of an individual.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Sites on an antigen that interact with specific antibodies.
Glycoproteins found on the membrane or surface of cells.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
An encapsulated lymphatic organ through which venous blood filters.
Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Antibodies produced by a single clone of cells.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Transport proteins that carry specific substances in the blood or across cell membranes.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Ubiquitously expressed integral membrane glycoproteins found in the LYSOSOME.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.
T-cell enhancement of the B-cell response to thymic-dependent antigens.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Mice bearing mutant genes which are phenotypically expressed in the animals.
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
The GENETIC RECOMBINATION of the parts of two or more GENES resulting in a gene with different or additional regulatory regions, or a new chimeric gene product. ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. ARTIFICIAL GENE FUSION is carried out in vitro by RECOMBINANT DNA technology.
Progenitor cells from which all blood cells derive.
An order of fish with 26 families and over 3,000 species. This order includes the families CYPRINIDAE (minnows and CARPS), Cobitidae (loaches), and Catostomidae (suckers).
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Compounds that bind to and stimulate PURINERGIC P2X RECEPTORS. Included under this heading are agonists for specific P2X receptor subtypes.

Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. (1/3469)

We have identified a novel gene in a gene trap screen that encodes a protein related to the DnaJ co-chaperone in E. coli. The gene, named Mrj (mammalian relative of DnaJ) was expressed throughout development in both the embryo and placenta. Within the placenta, expression was particularly high in trophoblast giant cells but moderate levels were also observed in trophoblast cells of the chorion at embryonic day 8.5, and later in the labyrinth which arises from the attachment of the chorion to the allantois (a process called chorioallantoic fusion). Insertion of the ROSAbetageo gene trap vector into the Mrj gene created a null allele. Homozygous Mrj mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, which precluded formation of the mature placenta. At embryonic day 8.5, the chorion in mutants was morphologically normal and expressed the cell adhesion molecule beta4 integrin that is known to be required for chorioallantoic fusion. However, expression of the chorionic trophoblast-specific transcription factor genes Err2 and Gcm1 was significantly reduced. The mutants showed no abnormal phenotypes in other trophoblast cell types or in the embryo proper. This study indicates a previously unsuspected role for chaperone proteins in placental development and represents the first genetic analysis of DnaJ-related protein function in higher eukaryotes. Based on a survey of EST databases representing different mouse tissues and embryonic stages, there are 40 or more DnaJ-related genes in mammals. In addition to Mrj, at least two of these genes are also expressed in the developing mouse placenta. The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities.  (+info)

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. (2/3469)

Csx/Nkx2.5 is a vertebrate homeobox gene with a sequence homology to the Drosophila tinman, which is required for the dorsal mesoderm specification. Recently, heterozygous mutations of this gene were found to cause human congenital heart disease (Schott, J.-J., Benson, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E. and Seidman, J. G. (1998) Science 281, 108-111). To investigate the functions of Csx/Nkx2.5 in cardiac and extracardiac development in the vertebrate, we have generated and analyzed mutant mice completely null for Csx/Nkx2.5. Homozygous null embryos showed arrest of cardiac development after looping and poor development of blood vessels. Moreover, there were severe defects in vascular formation and hematopoiesis in the mutant yolk sac. Interestingly, TUNEL staining and PCNA staining showed neither enhanced apoptosis nor reduced cell proliferation in the mutant myocardium. In situ hybridization studies demonstrated that, among 20 candidate genes examined, expression of ANF, BNP, MLC2V, N-myc, MEF2C, HAND1 and Msx2 was disturbed in the mutant heart. Moreover, in the heart of adult chimeric mice generated from Csx/Nkx2.5 null ES cells, there were almost no ES cell-derived cardiac myocytes, while there were substantial contributions of Csx /Nkx2.5-deficient cells in other organs. Whole-mount &bgr;-gal staining of chimeric embryos showed that more than 20% contribution of Csx/Nkx2. 5-deficient cells in the heart arrested cardiac development. These results indicate that (1) the complete null mutation of Csx/Nkx2.5 did not abolish initial heart looping, (2) there was no enhanced apoptosis or defective cell cycle entry in Csx/Nkx2.5 null cardiac myocytes, (3) Csx/Nkx2.5 regulates expression of several essential transcription factors in the developing heart, (4) Csx/Nkx2.5 is required for later differentiation of cardiac myocytes, (5) Csx/Nkx2. 5 null cells exert dominant interfering effects on cardiac development, and (6) there were severe defects in yolk sac angiogenesis and hematopoiesis in the Csx/Nkx2.5 null embryos.  (+info)

Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA. (3/3469)

Inheritable mutations in nucleotide excision repair (NER) genes cause cancer-prone human disorders, such as xeroderma pigmentosum, which are also characterized by symptoms of accelerated ageing. To study the impact of NER deficiency on mutation accumulation in vivo, mutant frequencies have been determined in liver and brain of 2-16 month old NER deficient XPA-/-, lacZ hybrid mice. While mutant frequencies in liver of 2-month old XPA-/-, lacZ mice were comparable to XPA+/-, lacZ and the lacZ parental strain animals, by 4 months of age mutant frequencies in the XPA-deficient mice were significantly increased by a factor of two and increased further until the age of 16 months. In brain, mutant frequencies were not found to increase with age. These results show that a deficiency in the NER gene XPA causes an accelerated accumulation of somatic mutations in liver but not in brain. This is in keeping with a higher incidence of spontaneous liver tumors reported earlier for XPA-/- mice after about 15 months of age.  (+info)

Ectopic expression of the transforming growth factor beta type II receptor disrupts mesoderm organisation during mouse gastrulation. (4/3469)

Transforming growth factor beta (TGFbeta) regulates the cell cycle and extracellular matrix (ECM) deposition of many cells in vitro. We have analysed chimaeric mouse embryos generated from embryonic stem cells with abnormal receptor expression to study the effect of TGFbeta on these processes in vivo and the consequences for normal development. The binding receptor for TGFbeta, TbetaRII, is first detected in the embryo proper around day 8.5 in the heart. Ectopic expression of TbetaRII from the blastocyst stage onward resulted in an embryonic lethal around 9.5 dpc. Analysis of earlier stages revealed that the primitive streak of TbetaRII chimaeras failed to elongate. Furthermore, although cells passed through the streak and initially formed mesoderm, they tended to accumulate within the streak. These defects temporally and spatially paralleled the expression of the TGFbeta type I receptor, which is first expressed in the node and primitive streak. We present evidence that classical TGFbeta-induced growth inhibition was probably the cause of insufficient mesoderm being available for paraxial and axial structures. The results demonstrate that (1) TGFbeta mRNA and protein detected previously in early postimplantation embryos is present as a biologically active ligand; and (2) assuming that ectopic expression of TbetaRII results in no other changes in ES cells, the absence of TbetaRII is the principle reason why the embryo proper is unresponsive to TGFbeta ligand until after gastrulation.  (+info)

Comparative analysis of cell distribution in the pigment epithelium and the visual cell layer of chimaeric mice. (5/3469)

In chimaeras of both rdrdCC in equilibrium ++ cc and rdrdcc in equilibrium ++CC combinations two types of distribution were observed. In a majority of the chimaeras both retinal layers were chimaeric; whereas in a few cases the pigment epithelium was chimaeric but the visual cell layer was made of ++ cells only. No spatial relation was observed in the distribution of the cells in the two layers. The two eyes of the individuals were nearly always identical with regard to occurrence of chimaerism in the two layers. The findings are discussed in the light of the possible site and mode of expression of the rd gene.  (+info)

Marmoset species variation in the humoral antibody response: in vivo and in vitro studies. (6/3469)

A comparison of the in vivo and in vitro antibody response capabilities of two marmoset species, Saguinus fuscicollis and Saguinus oedipus oedipus, revealed the former to be superior in elaborating humoral antibody. In vivo challenges with Escherichia coli lipopolysaccharide (LPS) and Salmonella typhi flagella consistently yielded higher antibody titres in S. fuscicollis; indeed, with LPS antigen, multiple inoculations of S.o. oedipus marmosets led ultimately to a decrease in antibody formation, in contrast to the anamnestic response of S. fuscicollis. This species differential in immune competence was also suggested in the in vitro stimulation of peripheral blood leucocytes (PBL) and spleen cells with sheep red blood cells (RBC). None of 55 S.o. oedipus PBL cultures and 49 of 89 (55%) S. fuscicollis cultures responded to the test antigen. A similar differential in response to sheep RBC was noted with the spleen cells of each species, although this report contrasts the antibody-forming potential of two marmoset species, a comparison of the immunological response profile of marmosets to those of other laboratory animals challenged with similar antigens suggests these primates may be relatively incompetent. The possible relationship between the haemopoietic chimerism of marmosets and a diminished immune competence is discussed.  (+info)

Bmp4 is required for the generation of primordial germ cells in the mouse embryo. (7/3469)

In many organisms the allocation of primordial germ cells (PGCs) is determined by the inheritance of maternal factors deposited in the egg. However, in mammals, inductive cell interactions are required around gastrulation to establish the germ line. Here, we show that Bmp4 homozygous null embryos contain no PGCs. They also lack an allantois, an extraembryonic mesodermal tissue derived, like the PGCs, from precursors in the proximal epiblast. Heterozygotes have fewer PGCs than normal, due to a reduction in the size of the founding population and not to an effect on its subsequent expansion. Analysis of beta-galactosidase activity in Bmp4(lacZneo) embryos reveals that prior to gastrulation, Bmp4 is expressed in the extraembryonic ectoderm. Later, Bmp4 is expressed in the extraembryonic mesoderm, but not in PGCs. Chimera analysis indicates that it is the Bmp4 expression in the extraembryonic ectoderm that regulates the formation of allantois and primordial germ cell precursors, and the size of the founding population of PGCs. The initiation of the germ line in the mouse therefore depends on a secreted signal from the previously segregated, extraembryonic, trophectoderm lineage.  (+info)

Interaction of B cells with activated T cells reduces the threshold for CD40-mediated B cell activation. (8/3469)

CD154-CD40 interactions are of central importance for the induction of antibody responses to T-dependent antigens. Since most anti-CD40 mAb are only weak B cell mitogens, it is believed that under physiological conditions, signals through CD40 synergize with those from other receptors on B cells to induce B cell activation. We show here that the interaction of either normal B cells, or those from CBA/N (xid) mice, with CD3-activated primary T cells in whole spleen cell cultures markedly reduces the threshold for B cell activation via CD40. Hence, these pre-activated cells undergo vigorous proliferation when stimulated with either optimal or suboptimal concentrations of weakly mitogenic anti-CD40 mAb, or with soluble CD40 ligand. Blocking experiments indicate that the establishment of this priming effect requires stimulation via CD40 itself, plus T cell-derived IL-2. In support of this concept, only CD3/CD28-pre-activated, but not CD3-pre-activated T cells induce this effect, unless the co-cultures of B cells with the latter T cells are supplemented with IL-2. Although B cells activated in this fashion do express higher levels of CD40 than naive cells, we believe that this is insufficient to explain the observed dramatic effects on their proliferative capacity. Rather we propose that T cell-dependent B cell activation induces fundamental changes in the signalling machinery invoked by ligation of CD40. It is likely that this amplification loop could play an important role during the initiation of antibody responses to T-dependent antigens, when activated CD4 T cells only express low levels of CD154.  (+info)

Results of our chimaera experiments revealed no evidence that BALB/c cells were preferentially allocated to the mTE but indicated they were at a selective disadvantage between E4.5 and E8.5. We confirmed previous reports that preimplantation BALB/c embryos lagged behind embryos of some other strains and showed that the relative stage of development attained by E2.5 embryos of different strains correlated with the contribution they made to chimaeras. This suggests that the poor contribution of BALB/c embryos to aggregation chimaeras is at least partly because they lag behind their partner embryos, due to delayed or slow development.. In principle, heterosis of non-inbred partner embryos might also have contributed to the poor contribution of BALB/c cells in BALB/c↔BF2, BALB/c↔(BF1×TGB) and BALB/c↔(BF1×TP6.3) chimaeras, if hybrid cells outgrow BALB/c cells. However, this does not explain the differences in compositions of (BALB/c×AF1)↔BF2 and (AF1×BALB/c)↔BF2 chimaeras (West et al., ...
In order to study the pattern of clonal myocyte distribution during mammalian heart development, we have exploited embryo aggregation chimeras using, as cellular markers, an enhanced jellyfish green fluorescent protein (eGFP) transgene and a desmin-promoter-driven, nuclear-localized beta-galactosidase (nlacZ) knock-in. In neonatal, weanling, and adult chimeric atria and ventricles, irregularly formed patches of various sizes rather than highly dispersed cardiomyocytes were observed. Most of the smaller patches and single cardiomyocytes were found in spatial neighborhood of large patches. This indicated largely coherent clonal growth during myocardial histogenesis combined with tangential displacement or active migration of myocytes. The patterns of ventricular walls were simpler than those of the septum and the atria. In the adult heart, large myocardial volumes devoid of eGFP-positive cardiomyocytes indicated a lack of secondary immigration of blood-borne stem cells into the myocardium. The ...
Although telomere length is genetically determined, mouse embryonic stem (ES) cells with telomeres of twice the normal size have been generated. Here, we use such ES cells with hyper-long telomeres, which also express green fluorescent protein (GFP), to generate chimaeric mice containing cells with both hyper-long and normal telomeres. We show that chimaeric mice contain GFP-positive cells in all mouse tissues, display normal tissue histology and normal survival. Both hyper-long and normal telomeres shorten with age, but GFP-positive cells retain longer telomeres as mice age. Chimaeric mice with hyper-long telomeres also accumulate fewer cells with short telomeres and less DNA damage with age, and express lower levels of p53. In highly renewing compartments, such as the blood, cells with hyper-long telomeres are longitudinally maintained or enriched with age. We further show that wound-healing rates in the skin are increased in chimaeric mice. Our work demonstrates that mice with functional, ...
Detecting chimeric (or recombinant) sequences from a sequence dataset is an important part of sequence analysis especially for reconstruction of deep phylogenies as well as for sequence similarity analyses. This article focuses on methods of chimera detection in high quality 16S rRNA sequences from Sanger sequencing with good read length (,750bp). With such large size they become potential candidates for chimera formation. With culture-independent approaches for analyses of microbial diversity picking up fast with high throughput sequencing methods, the amount of chimeric sequences being published in the databases are also increasing exponentially. This is the era of Metagenomics or simply put community DNA analyses where DNA from thousands of species gets pooled up and is then analysed. This further increases chances of chimera formation. Chimeras are usually formed during polymerase chain reaction (PCRs) but in some rare cases they are for real. Therefore, it becomes relevant to adopt methods ...
A pillar is a firm upright support (1) for something. A pillar may stand alone or it may support a superstructure. The article of Beatrice Mintz and Willys Silvers (2) discussed here on grafting using allophenic mice is appropriately called a pillar of immunology for which the superstructure is yet to be completed.. Mintz and Silvers posed a question long considered fundamental to immunology: What is the origin of intrinsic tolerance. Intrinsic tolerance refers to the natural condition of specific nonresponsiveness to self. More than 60 years before, Ehrlich and Morgenroth had reasoned that injury and atrophy of tissues might lead to the development of immune reactions against autologous cells, but the occurrence of such reactions would be dysteleological in the highest degree (3). To explain why autologous reactions usually do not arise, Ehrlich and Morgenroth proposed that organisms must have a horror autotoxicus mediated by some regulating contrivances and believed that studying these ...
Evans, R, Host cell contribution to successful neoplastic cell proliferation, p. 9-17. In congress of italian immunology & pathology society. Milan (1981). Subject Strain Bibliography 1981. 2343 ...
Hood, D.C., Frishman, L.J., Viswanathan, S., Robson, J.G., & Ahmed, J.(1999). Evidence for a ganglion cell contribution to the primate electroretinogram (ERG): Effects of TTX on the multifocal ERG in macaque. Visual Neuroscience, 16(3), 411-416.. ...
There is an overall lack of knowledge about how vaccines work. Here we propose the combined use of reverse genetics and bone marrow...
Bio-protocol is an online peer-reviewed protocol journal. Its mission is to make life science research more efficient and reproducible by curating and hosting high quality, free access protocols.
Allophenic:, Genes: a - Non-agouti, b - Brown, c*ch - Chinchilla, D, d - Dilute, D-Locus, p - Pink-eyed dilution, se - Short-ear, wa-2 - Waved-2, Strains: C3H, C57BL, Unknown:. ...
Chimera is a network impairment emulator that makes it easy to introduce consistent, accurate, well-defined and repeatable impairments (e.g. packet manipulation, latency, jitter, bandwidth control and shaping) to traffic between DUTs in the lab. All rates from 10GE to 100GE are supported by a single 2-slot test module.. Chimera is ideal for NEMs who want to optimize Quality of Experience (QoE) for customers by ensuring their equipment can handle acceptable levels of impairment. Service providers, enterprises, and government agencies can also use Chimera to validate Quality of Service (QoS) for voice, video, and data traffic being sent across their networks.. Chimera can be used a standalone solution, but it can also be installed as a test module in a ValkyrieBay chassis for seamless integration with ValkyrieManagers traffic generator. This provides a really simple way of emulating impairment to traffic being generated via Valkyrie all from the same GUI. ...
Treasure standard. Chimeras are monstrous creatures born of primordial evil. Hateful and hungry, they hunt on the ground or in the air. A chimeras dragon head may be of any evil dragon type, with the corresponding breath weapon, and its wings usually match the scales on its head. Chimeras speak with three overlapping voices, but rarely do so, typically only when playing toady to a more powerful creature. A chimera is 5 feet tall at the shoulder, nearly 10 feet long, and weighs 700 pounds.. Chimeras prefer meat but can subsist on vegetable matter if necessary (although being forced to do so generally leaves the beasts more ill-tempered than usual). Their flight means they can pick and choose their prey, and they usually hunt a large area in search of easy food. They are too stupid and belligerent to acquire followers, though sometimes a tribe of kobolds might give them offerings. Conversely, they are just intelligent and stubborn enough that they make poor pets, and only a significantly more ...
From what we can gather, Chimera v1.2.9 bundles package updates that were issued by the Electra Team shortly after Chimera v1.2.8 was released, and more importantly, it resolves issues that would transpire while attempting to download and install certain packages with Sileo.. If youre using an earlier version of Chimera than v1.2.9, then wed advise updating to the latest at your earliest convenience to take advantage of the latest features and improvements.. If youd like to jailbreak your compatible iOS 12.4 handset with Chimera v1.2.8, then you can download it from the Electra teams official Chimera website. You can also follow the steps outlined in our updated Chimera tutorial if you havent jailbroken your device before. ...
The IMSR is a searchable online database of mouse strains, stocks, and mutant ES cell lines available worldwide, including inbred, mutant, and genetically engineered strains. The goal of the IMSR is to assist the international scientific community in locating and obtaining mouse resources for research. Note that the data content found in the IMSR is as supplied by strain repository holders. For each strain or cell line listed in the IMSR, users can obtain information about: Where that resource is available (Repository Site); What state(s) the resource is available as (e.g. live, cryopreserved embryo or germplasm, ES cells); Links to descriptive information about a strain or ES cell line; Links to mutant alleles carried by a strain or ES cell line; Links for ordering a strain or ES cell line from a Repository; Links for contacting the Repository to send a query ...
Using complementary targeting strategies, the IKMC centers design and create targeting vectors, mutant ES cell lines and, to some extent, mutant mice, embryos or sperm. Materials are distributed to the research community.. The KOMP Repository archives, maintains, and distributes IKMC products. Researchers can order products and get product information from the Repository. Researchers can also express interest in products that are still in the pipeline. They will then receive email notification as soon as KOMP generated products are available for distribution.. The process for ordering EUCOMM materials can be found here.. The process for ordering TIGM materials can be found here.. Information on NorCOMM products and services can be found here. Genes were mapped to the human genome by IKMC. ...
The monkey embryos were injected with human stem cells 6 days after they were created, which can yield multiple different types of tissue, both embryonic and non- or extra-embryonic tissues, the report notes.. The human cells were still found in 132 chimera embryos 24 hours after implantation. 109 embryos continued to develop after 9 days. After day 19, only 3 embryos remained. After 20 days, all of the embryos had been destroyed.. Researchers were able to examine the resultant embryos to determine which communication pathways between the monkey and human cells were viable in the generation of future chimeras and which were not.. The team said it gave the utmost attention to ethical considerations… by coordinating closely with regulatory agencies during their research.. Technology developed by Weizhi Ji and his team at Kunming University of Science and Technology in Yunnan, China has made the attempts at chimeras - which have been ongoing since the 1970s - ...
The IMSR is a searchable online database of mouse strains, stocks, and mutant ES cell lines available worldwide, including inbred, mutant, and genetically engineered strains.
The IMSR is a searchable online database of mouse strains, stocks, and mutant ES cell lines available worldwide, including inbred, mutant, and genetically engineered strains.
Each instance of Gene Cloud is centered around a specific gene. A list of the top most related genes is plotted as a branching structure from the center. A secondary branch can occur if a gene in the graph is more related a non-central gene than it is to the center gene. The font size of a branched gene indicates the relative strength of connection--always to the center gene. The distribution of genes in space is randomized each time Gene Cloud is run so a different picture will result for the same central gene. Color is used to indicate the availability of Knockout Mouse products at the KOMP Repository. If a gene is colored green in the graph there are products (mutant ES cells, sperm, embryos, or mice) ready to be ordered. Blue colored genes do not yet have products available, but you can follow the links back to the KOMP Repository and register interest to be alerted when products do become available. At this time the length of an edge connecting two genes does not contain any information, ...
Each instance of Gene Cloud is centered around a specific gene. A list of the top most related genes is plotted as a branching structure from the center. A secondary branch can occur if a gene in the graph is more related a non-central gene than it is to the center gene. The font size of a branched gene indicates the relative strength of connection--always to the center gene. The distribution of genes in space is randomized each time Gene Cloud is run so a different picture will result for the same central gene. Color is used to indicate the availability of Knockout Mouse products at the KOMP Repository. If a gene is colored green in the graph there are products (mutant ES cells, sperm, embryos, or mice) ready to be ordered. Blue colored genes do not yet have products available, but you can follow the links back to the KOMP Repository and register interest to be alerted when products do become available. At this time the length of an edge connecting two genes does not contain any information, ...
Giorgio Mario Provolo is the new member in the External Users Advisory Board (EUAB) of CHIMERA - CHIckens Manure Exploitation and RevAluation: Professor of the University of Milan, Department of Agricultural and Environmental Sciences - Production, Territory, Agroenergy - he has joined the EUAB of CHIMERA. EUAB aims to involve stakeholders (institutions, research centers, breeders, plant producers, etc.), in order to participate in networking and disseminating activities for the potential of the technology generated. EUAB members receive information on the progress of the project, with the possibility of being involved in workshops, visits to prototypes and plants: feedback are very important for the development of CHIMERA and the possibility that the concept of the project can be transferred to other management contexts of the organic waste / biomass cycle, for the replicability of the results.. Find out how to become part of CHIMERA EUAB. ...
In mythological literature, we are shown that the chimera achieves its robustness through the incorporation of the most valued elements of other feared animals. Based upon an extensive literature compiled over more that a decade, the GPCR chimera can be viewed in a similar manner. Chimeras have been created successfully from the three major domains borrowed from most of the classes that compose the GPCR superfamily. Each of these chimera provided important insight into the functional roles of specific domains in ligand recognition, receptor activation, downstream signaling, and receptor trafficking. Perhaps the most remarkable feature to emerge from all of these chimeras is that they are functional, highlighting some nearly universal properties about how GPCRs function. The exofacial and 7TMS core of the β2AR seems to provide a mechanosensing device capable of converting the binding of agonist into some physical force on GPCR cytoplasmic domains or those borrowed from a distantly-related 7TMS ...
Note: Solar Monitors coronal hole segmentations are performed by CHIMERA, a copy of which is available at: The operations of the CHIMERA algorithm is described in a peer reviewed paper: An extensive copy of coronal hole properties are available at: The latest positions of the coronal holes are given in heliocentric co-ordinates, and the region positions are valid on 27-Oct-1997 23:30. ...
Note: Solar Monitors coronal hole segmentations are performed by CHIMERA, a copy of which is available at: The operations of the CHIMERA algorithm is described in a peer reviewed paper: An extensive copy of coronal hole properties are available at: The latest positions of the coronal holes are given in heliocentric co-ordinates, and the region positions are valid on 12-Oct-2019 23:40 UT . ...
Set: Theros Type: Creature - Chimera Uncommon Cost: {1}{U}{R} Flying, trample Spellheart Chimeras power is equal to the number of instant and sorcery cards in your graveyard. Thaumaturges remain silent around chimeras, lest their words conjure even stranger beasts.
Chimeric genes play an integral role in molecular biological research. One such example is the GAL4-UAS system. By combining the upstream activation site (UAS) for the yeast gene GAL4 with your gene of interest, you can cause your gene to be activated in the presence of GAL4. These chimera arent structurally different (i.e., it is still the same protein), but instead of the normal regulatory elements associated with the gene, it now has the yeast UAS. A researcher can control where the GAL4 gene is expressed by creating a chimera made up of the GAL4 gene and a regulatory element for a certain tissue. Wherever GAL4 is expressed, your gene of interest will be expressed because it has been fused to the UAS ...
for example, one from the donkey and one from the horse. Chimera is a broad term and is often applied to many different types of mixing of cells from two different species.. Some chimeras can result in the eventual development of an adult animal composed of cells from both donors, which may be of different species - for example, in 1984 a chimeric geep was produced by combining embryos from a goat and a sheep.[8 ...
Im just glad to be here. -Cherub Cherub is a hybrid clone and a playable agent in XCOM: Chimera Squad. As part of the clone batch dubbed the Empty Cohort, Cherub had received ADVENT training but never received ADVENT indoctrination when he was born at the end of the war. After befriending the X-COM agents who discovered his clone creche and having been found to possess no ADVENT sympathies despite being part of a clone line derived from the infamous ADVENT general Bellus Mar, he was recommended as a test case for the use of the Empty Cohorts skill set. He was subsequently transferred to Reclamation and placed in Chimera Squad at his request. Cherub wields a pistol and energy shield, and has several abilities to protect himself and others. Though his offensive ability is lacking, he can force enemies to focus their attacks on him to give his allies the opportunities they need to strike. ...
Side-by-side views of a potassium channel structure (Protein Data Bank entry 1bl8) showing different approaches to cavity detection. On the left are molecular surface patches in darker and lighter pink corresponding to the structures two largest pockets by MS volume in the Computed Atlas of Surface Topography of proteins (CASTp) database. CASTp pocket information can be fetched directly from within Chimera. On the right is a tunnel in blue identified by the MolAxis server. The downloaded result file 1bl8.graph_pathway_0_all was converted to a Chimera BILD file by simply inserting .sphere at the beginning of each line and adding the line .color blue at the top (format description). The orthographic projection is shown (perspective has been turned off), the background is tan, and the image includes silhouette edges and 2D labels. The subdivision quality is 5.0 and the molecular surface vertex density is 6.0. The entry Sliced Potassium Channel provides yet another view of the same structure. ...
Reciprocal hybrids showing different phenotypes have been well documented in previous studies, and many factors accounting for different phenotypes have been extensively investigated. However, less is known about whether the profiles of small RNAs differ between reciprocal hybrids and how these small RNAs affect gene expression and phenotypes. To better understand this mechanism, the role of small RNAs on phenotypes in reciprocal hybrids was analysed. Reciprocal hybrids between Solanum lycopersicum cv. Micro-Tom and S. pimpinellifolium line WVa700 were generated. Significantly different phenotypes between the reciprocal hybrids were observed, including fruit shape index, single fruit weight and plant height. Then, through the high-throughput sequencing of small RNAs, we found that the expression levels of 76 known miRNAs were highly variable between the reciprocal hybrids. Subsequently, a total of 410 target genes were predicted to correspond with these differentially expressed miRNAs. Furthermore, gene
Recurrent Double Donor Embryo Implantation Failure. Braverman IVF & Reproductive Immunology answers this question and more in this forum!
Murine fibroblasts expressing viral receptors and human cyclin T1 allow HIV-1 entry and viral gene expression but do not support efficient assembly. A chimeric HIV-1 carrying a non-homologous matrix (MA) from murine leukemia virus in place of HIV-1 MA can assemble efficiently in murine cells, yet has poor infectivity. Here, we assess the ability of a homologous MA from SIV MAC239 to complement assembly and infection in chimeric viruses designated SHIV(MA). The resulting SHIV(MA) chimeras produce more virus than native HIV-1 when transfected into murine cells. SHIV(MA) exhibits cell-type-specific replication in human T cell lines, replicating well in MT4 cells and poorly in Jurkat cells due to an incompatibility with the HIV-1 Env. The infectivity defects of SHIV(MA) are rescued by pseudotyping with VSV-G but not by truncation of the cytoplasmic tail of Env. Passage of SHIV(MA) in Jurkat cells produces variants with improved Env incorporation and improved replication in Jurkat but not in 3T3 TXC ...
Our study has four major findings. First, iPSCs were successfully established from an endangered species, T. osimensis. Second, the culture condition of the combination of N2B27 2iL with SB590885 (N2B27 3iL) medium induced a high naïve pluripotency. Third, these iPSCs effectively contributed to mouse embryos or pups as interspecific chimera with germline contribution. Finally, XO female iPSCs could differentiate into male germ cells in the interspecific mouse testis and survive for more than 7 weeks after birth. Derivation of iPSCs and production of live animals as chimeras using this unique species may provide new insights into the mechanisms of sex determination after disappearance of the Y chromosome during mammalian evolution. Moreover, derivation of naïve-state iPSCs from endangered species may be effective both for conserving genes and cells and as a source for germ cell generation.. Recently, iPSC generations of endangered species were achieved in orangutan, drill, and northern white ...
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We evaluated the biological origin of host-virus (mosquito-DENV) recombination by comparing its rate to that of recombination between genomes (pillbug-DENV) that never were in contact in a cellular context. This control indicated that the DENV genome and the genome of its mosquito host did not recombine in vivo to a detectable extent, hence, that most, if not all, virus-host chimeras were artificially produced.. We also uncovered within-genome chimeras (e.g., DENV-DENV chimeras) in greater numbers. To assess their biological origin, chimeras involving the genomes of species that were not in contact prior to DNA processing (e.g., pillbug-DENV chimeras) cannot be used as a baseline expectation because they necessarily occurred between different molecules, contrary to within genome chimeras, which most frequently occurred within the same molecule (see below). Thus, they are not informative. However, it is notable that the various within-genome chimeras we detected in datasets obtained with the ...
The Chimera was the first production bike with the aircooled, horizontal single-cylinder four-stroke engine which Aermacchi is most famous for. The engine later was available as 250cc version as well and it was the basis for the 350cc engine which continued until 1974 as well.. The Chimera was designed by Mario Revelli de Beaumont and constructed by Alfredo Bianchi as technical leader. It was presented on December 1st in 1956 at the Milan motorcycle show. They engine had 175cc and produced 10hp at about 6800 rpm. The bike had a futuristic airstream look and was equipped with monoshock suspension. In their opinion the Chimera was the ideal motorcycle and the name Chimera represents that as it translates to dream.. The Chimera however was not a success as people didnt like the look of the plastic panelling. The Chimera was also available as a 250cc version. However, the Chimera was very important as it marks the beginning of The Aermacchi engine.. ...
What if a bunny wants to swing from trees? What if a monkey really likes carrots? What if an elephant wants to fly? What if a bat wants to be super strong?. Chimeras make all of this possible. With interchangeable ears, arms, and legs, Chimeras makes plush toys more dynamic and more fun. Chimeras will come in pairs, so that kids can start exchanging body parts immediately. The first two pairs are Monkey & Bunny and Elephant & Bat.. Walrus Toys has taken to Kickstarter to help raise funds to get their Chimeras line produced. Theyre looking to raise $20,000 by Thursday September 6th 2012 at 5:34PM ET. And there are plenty of funding incentives available for supporters.. ...
You should use Ctrl+C (SIGINT) to stop chimera.. The -I on chimera tells Chimera where to look for instruments, this case to look in your $HOME directory (you can use any directory there, . for example). Then to -i we pass a valid Chimera Location. From the Location, Chimera knows that you want to create an instance of Example1 class and call this instance example.. You can also pass configuration parameters right on the Location given in the command line. Use:. ...
TY - JOUR. T1 - Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. AU - Santarelli, Justin G.. AU - Udani, Vikram. AU - Yung, Yun C.. AU - Cheshier, Sam. AU - Wagers, Amy. AU - Brekken, Rolf A.. AU - Weissman, Irving. AU - Tse, Victor. PY - 2006/8/1. Y1 - 2006/8/1. N2 - OBJECTIVE: Neoangiogenesis is a prerequisite for the full phenotypic expression and growth of a malignant tumor mass. It is believed to be triggered by tissue hypoxia and involves proliferation and sprouting of the preexisting vessels and the recruitment of endothelial progenitor cells from bone marrow. METHODS: A chimeric mouse model was used to examine the contribution of these progenitor cells to the neovasculature of brain tumor. T-cell knockout (RAG/KO5.2) mice were irradiated lethally, and their bone marrow was repopulated with T-cell depleted green fluorescent protein (GFP)-expressing bone marrow cells. RAG/RT-2 glioma cells were implanted into the ...
The Latin word chimaera means monster, so the name chimaera perfectly fits these strange-looking, scaleless ghost sharks. There are about 25 species of chimaera. Like sharks, all chimaera have a thick body and a cartilaginous (CAR-tuh-LÄ-juh-nus) skeleton. A cartilaginous skeleton is made of cartilage (firm, flexible tissue) instead of bone.. The chimaera is similar to a shark or ray in many ways, but is different from sharks because it lacks the sharp, replaceable teeth of sharks. Instead, the chimaera has rat-like teeth. Also, the chimaeras skin is different. It has only a single pair of gill slits, and its upper jaw is attached to its skull. Even though the chimaera is not a shark, we should still avoid it. Most chimaera have a venomous spine directly in front of their dorsal fin. This sharp spine can inflict painful wounds on humans or animal predators, which include larger fish and sharks. The largest chimaera reach a length of about six and a half feet.. Chimaera are called deep-water ...
About PhoenixBio Co, Ltd.: A public company produces the PXB-Mouse®, the worlds most widely used humanized liver chimeric mouse model, for drug discovery and development. With very high replacement of human hepatocytes in the liver, the PXB-Mouse provides clinically relevant data in the fields of HBV/HCV, DMPKS/Safety, oligonucleotide therapeutics and non-viral liver diseases. The translatability of the PXB-Mouse model enables accelerated pre-clinical drug development and reduces the risk of failure at the clinical development stage. The PXB-Mouse is the reliable, cost-effective, next step for your pre-clinical drug development ...
What is the issue?. It has recently been recognised that a specific brand of medical device used in open-heart surgery, known as a heater-cooler unit, has the potential to be contaminated with an uncommon environmental bacterium called Mycobacterium chimaera (M. chimaera), which grows in the units water tank.. The water and the heater-cooler unit itself never comes into contact with the patients blood or body fluids. M. chimaera can become airborne from the heater-cooler device, and can make contact with a patients wound during open heart surgery, potentially resulting in infection. The risk of infection however is very low.. What are heater-cooler units?. Heater-cooler units are life-saving medical devices used during open-heart surgery. These units are used around the world, including in Australian hospitals.. Heater-cooler units enable doctors to regulate the temperature of the patients blood during the surgery. The machine uses water to warm or cool the blood as it is circulated outside ...
Activation of A2A adenosine receptors (A2ARs) protects kidneys from ischemia-reperfusion injury (IRI). A2ARs are expressed on bone marrow-derived (BM-derived) cells and renal smooth muscle, epithelial, and endothelial cells. To measure the contribution of A2ARs on BM-derived cells in suppressing renal IRI, we examined the effects of a selective agonist of A2ARs, ATL146e, in chimeric mice in which BM was ablated by lethal radiation and reconstituted with donor BM cells derived from GFP, A2AR-KO, or WT mice to produce GFP→WT, A2A-KO→WT, or WT→WT mouse chimera. We found little or no repopulation of renal vascular endothelial cells by donor BM with or without renal IRI. ATL146e had no effect on IRI in A2A-KO mice or A2A-KO→WT chimera, but reduced the rise in plasma creatinine from IRI by 75% in WT mice and by 60% in WT→WT chimera. ATL146e reduced the induction of IL-6, IL-1β, IL-1ra, and TGF-α mRNA in WT→WT mice but not in A2A-KO→WT mice. Plasma creatinine was significantly greater ...
Chimera Lighting has been hand making quality products for the photographic, cinematic and broadcast markets for over 35 years. Chimera works closely with all the major brands through the product development cycle, ensuring that everyones product performs as efficiently and effectively as possible. Chimera Lighting takes pride in our ability to expand the range and versatility of our partners products.. Chimera products are designed and manufactured in Boulder Co. with pride and experience of 35 years. If you have a product or project that you think could benefit from our experience, please fill out the form, provide a brief overview of your project and we will get back to you shortly.. ... 0 0 Chimera Lighting Chimera Lighting2017-02-21 07:53:102017-07-03 13:37:17How do you pronounce Chimera? ...
The cost of using donor eggs or embryos. In our Financial Breakdown, we provide a transparent overview of costs associated with our programs.
Hi, My husband, Michael, and I met 19 years ago and have been married for nearly 16 years. We began our journey to start our family over 12 years ago. After suffering from endometriosis, numerous surgeries, ovarian cysts and years of
R&D Systems™ Mouse ICAM-2/CD102 Fc Chimera Recombinant Protein 50ug; Carrier Free R&D Systems™ Mouse ICAM-2/CD102 Fc Chimera Recombinant...
Chimera Tool Samsung Dongle (Authenticator) is a dongle with pre-activated Chimera Tool PRO License Activation that will allow you to service BlackBerry, Samsung, LG, HTC, Huawei and Nokia phones.. Please note. This dongle is valid for one year only! After the expiration you will have to purchase Chimera Tool PRO License Activation if you want to continue using ChimeraTool software.. ...
Listen to Cursed Chimera Radio, free! Stream songs by Cursed Chimera & similar artists plus get the latest info on Cursed Chimera!
mutation in these p53+ epithelial cells from the kidney transplant. These findings provide evidence for a donor epithelial cell contribution to the malignant skin epithelium in the recipient in the setting of allogeneic kidney transplantation. This finding has theoretical implications for cancer initiation and progression and clinical implications in the context of prolonged immunosuppression and longer survival of kidney transplant patients. ...
Based on Powers & Shoichet 2002 paper on characterizing the AMPC binding site: Characterizing the β-lactamase binding site Chimera tutorial by Reed Stein, 2015 for course at UCSF. 1. Open Chimera 2. Select an atom or residue by holding CTRL and clicking 3. Rotate the protein by clicking anywhere on the protein and swiping on the trackpad 4. Zoom in/out by clicking anywhere with two fingers and swiping the trackpad 5. Translate the protein by clicking on it with three fingers and swiping the trackpad 6. Favorites → Command Line 7. Type open 1L2S on the command line. To select chain A, type sel :.a. (Alternatively, Select → Chain → A. Objects that are selected are highlighted in green.) 8. To delete chain A, type del sel (Actions → Atoms/Bonds → delete) 9. To center the protein, type focus (Actions → focus) 10. To select the catalytic residue, type sel :64 (Favorites → Sequence. Select residue 64 by clicking and dragging the cursor over the residue.) 11. To display the ...
Viral CCI, Unconjugated, Fc Chimera from R&D Systems,Recombinant Viral CCI/Fc Chimera, CF,biological,biology supply,biology supplies,biology product
A Chimera is any object, animate or inanimate, from the Dreaming, or made of the essence of the Dreaming. In practical use, "chimera" refers to an animate and likely sentient creature of the Dreaming, while an inanimate object would be referred to as "chimerical " (e.g. a chimerical sword). Even...
Tajima Atsushi , Barbato Guy F. , Kuwana Takashi , HAMMERSTEDT Roy H. The journal of poultry science 40(1), 53-61, 2003-01-25 J-STAGE 参考文献20件 被引用文献7件 ...
When cells-but not DNA-from two or more genetically distinct individuals combine to form a new individual, the result is called a chimera. Though chimeras occasionally occur in nature, scientists have produced chimeras in a laboratory setting since the 1960s. During the creation of a chimera, the DNA molecules do not exchange genetic material (recombine), unlike in sexual reproduction or in hybrid organisms, which result from genetic material exchanged between two different species. A chimera instead contains discrete cell populations with two unique sets of parental genes.. Format: Articles Subject: Organisms, Processes ...
When cells-but not DNA-from two or more genetically distinct individuals combine to form a new individual, the result is called a chimera. Though chimeras occasionally occur in nature, scientists have produced chimeras in a laboratory setting since the 1960s. During the creation of a chimera, the DNA molecules do not exchange genetic material (recombine), unlike in sexual reproduction or in hybrid organisms, which result from genetic material exchanged between two different species. A chimera instead contains discrete cell populations with two unique sets of parental genes.. Format: Articles Subject: Organisms, Processes ...
Hi netters! I have a copy of mulfold for the Mac. A limitation of this version: one can only fold a 300 base sequence. I, however, have a sequence of ~4000 that I want to fold to see if the start codon or SD domain could potentially interact with bases more distant than the neighboring ~150 bases (and the effect of mutations in these more distant domains on this interaction). Is there anyway I could do this without constructing some chimeric sequence between the initiation region and the distant region of interest (I dont think the results I would get from this would be very realistic)? Do you thing it is reasonable (thermodynamically) for a such a distant region (say ~500 bases away) to base pair with the initiation region? (I cant, for certain, justify one or the other because I cant do the folding!). What are the limitations for the UNIX version?? Help! Thanks for your time! Yours truly, erik ...
Buy DDR1, Fc Chimera recombinant protein (MBS638129) product datasheet at MyBioSource, Recombinant Proteins. Application: ELISA (EL/EIA)
We take a look at iBUYPOWERs spectacular looking and high performance Chimera 4SE gaming desktop PC in our return to desktop reviews. (Page 2 of 11)
Qui presentiamo lassemblaggio di chimera mediante il recupero del plasmide e linserimento del sito enzimatico di restrizione ...
Gentaur molecular products has all kinds of products like :search , Neuromi \ Recombinant Mouse Ret_Fc Chimera CF, 100 ug.. \ PR15049CF-100 for more molecular products just contact us
Buy our Recombinant mouse TNFSF18 protein (Fc Chimera Active). Ab219721 is an active protein fragment produced in HEK 293 cells and has been validated in…
Chimera Pro Panel Kits are a great starter in the Panel Frame System, and come complete with the frame, 1/2-Grid Diffusion Fabric, White/Black Fabric, and a durable storage duffle. Key Features Durable aluminum construction Mounts to stand with standard 2.5-inch grip head (not included) Internal elastic cable for eas
This video demonstrates how to create a mutation in UCSF Chimera and to choose a rotamer. Once youve saved your file, you can upload your customized molecular model to the site to convert it to a 3D printable file!. Click hereto see Part 1 of the tutorial.. This tutorial was created by Dr. Darrell Hurt, as part of training offered from the NIAID Bioinformatics and Computational Biosciences Branch.. ...
Semantic Scholar extracted view of [Chimeras from regulatory peptides as a device for studying their action]. by E. P. Kharchenko et al.
Aputure is proud to be teaming up with Chimera, the world leader in diffusion solutions for the film and television industry, on the creation of a new Lightbank accessory for Aputures flagship panel, the LS-1.. ...
Chimera Media Limited - Sign up to Vision-Net to get CRO Documents such as Company Accounts, Director and Mortgage Information or Credit Reports for this Irish company
Read more information about the character Hiko Saigaura from Croa Chimera? At MyAnimeList, you can find out about their voice actors, animeography, pictures and much more! MyAnimeList is the largest online anime and manga database in the world! Join the online community, create your anime and manga list, read reviews, explore the forums, follow news, and so much more!
1.1 hyatt 1: // 2: // 3: // Chimera 4: // 5: // Created by David Hyatt on Thu Apr 18 2002. 6: // Copyright (c) 2001 __MyCompanyName__. All rights reserved. 7: // 8: 9: #import CHGetURLCommand.h 10: #import ,AppKit/AppKit.h, 11: 12: @implementation CHGetURLCommand 13: 14: - (id)performDefaultImplementation { 1.2 ! hyatt 15: id controller = [[NSApp delegate] openBrowserWindowWithURLString: [self directParameter]]; ! 16: [[[controller getMyBrowserView] getBrowserView] setActive: YES]; 1.1 hyatt 17: return nil; 18: } 19: @end ...
What follows is a work-in-progress, my collaboration with fellow Chimera member Viviana Hinojosa. It works in much the same way as echovirus12; Viviana started the process by creating a picture, which I then interpreted freely in the form of a prose poem. My piece then became the springboard for Vivianas next picture, and so on.…
Chimera[edit]. A chimera is an animal (e.g., human) with double the standard DNA formed by the fusion of two embryos. Chimeras ... In] the copyright wars,'... we're dealing with a chimera. [I]n the battle over... 'What is p2p sharing?' both sides have it ...
Classe Chimera[editar , editar código-fonte]. Batizada em homenagem a mythical chimaera. ... USS Chimera. NCC-[?]. nave homônima presumível para a classe.. USS Portland. NCC-57418. Searches the Algira sector for Odo and ...
Chimera. ISBN 9781903136522. Linsey Dawn McKenzie at IMDb Linsey Dawn McKenzie at the Internet Adult Film Database Linsey Dawn ...
CS1 maint: discouraged parameter (link) Cliff Bole (director); David Amann (writer) (April 2, 2000). "Chimera". The X-Files. ...
"Chimera". Baen Books. Sharon Lee and Steve Miller. "Wise Child". Baen Books. Sharon Lee and Steve Miller. "Out of True". Baen ...
Fox.CS1 maint: others in cite AV media (notes) (link) Cliff Bole (director); David Amann (writer) (April 2, 2000). "Chimera". ... "Chimera". Guest star J. Douglas Stewart, who portrays Larry Bangs, later appeared in the second season episode "Monster" in an ...
The other two books in the series are Symbiont (November 25, 2014) and Chimera (November 24, 2015). The book, in the tradition ... ISBN 978-0-316-21899-3. Grant, Mira (November 24, 2015). Chimera. Orbit. ISBN 978-0-316-38103-1. Valentine, Genevieve (30 ...
Chimera. Talonbooks, 2007. ISBN 978-0-88922-569-5. Chan, Marjorie Chan. China Doll. SHI, year?. ISBN 978-0-920486-83-2. ... Nolan The Child by Keith Dorland Children of the Night by Gabriel Emanuel The Children of the Night by Paul Ledoux Chimera by ...
Chimera. Older brother of Trakhan. As for the character which becomes the cause minelander. Japanese: マルチココパ Korean: 트라칸 Voiced ...
Chimera; Steve (June 1994). "Mario's Time Machine". GameStar. No. 1. pp. 66-67. Retrieved February 20, 2021. Simane, Kirron ( ...
Harold Augenbraum (July 29, 2009). "Chimera". NBA Fiction Blog. Archived from the original on 2009-08-08. "National Book Awards ... Chimera 1973: John Edward Williams - Augustus Brock Brower - The Late Great Creature Alan H. Friedman - Hermaphrodeity Barry ...
"UCSF Chimera". Chimera. Retrieved 25 October 2019. "AcrIIA4 - PDB". Protein Data Bank. doi:10.2210/pdb5xn4/pdb. Retrieved 2019- ...
"Virtual Reality Lighting with Andrew Shulkind - Chimera Lighting". Chimera Lighting. 2017-05-23. Retrieved 2018-02-14. "Andrew ...
"Shane Berkery Exhibition at The Chimera Gallery, Mullingar". Chimera Gallery. 2017-05-30. Retrieved 2017-11-20. "187th Annual ... Chimera Gallery. Joint Exhibition with Ruby Wallis "For each it is different and the same" at Artist-Run Gallery, Galway, ... at The Chimera Gallery, Mullingar, Ireland - May 2017 RHA 187th Annual Exhibition at Royal Hibernian Academy, Dublin, Ireland ...
Chimera, Manuela. "San Benedetto del Tronto, un lungomare di palme e giardini con fontane" (in Italian). Retrieved 29 March ...
... chimera' represents an egg from which an hybrid creature, a chimera, comes out. The chimera symbolizes metaphorically the band ... "chimera". The title alludes to the band's image as it is today : a chimera being an hybrid creature just like the band's music ... Rage is the key-word of the concept of 'chimera'. It's Satoshi's idea. He's the one who designed it". Girugamesh toured in ... "VerdamMnis Music E-Magazine , Interviews , girugamesh : chimera , Février 2016". Retrieved 2016-03-03. " ...
Parting the Veil: The Art of Nene Thomas was published by Chimera Publishing in 2010. She partnered with fantasy artist Cindy ... Chimera Publishing. ISBN 9780974461298. Retrieved July 5, 2015. CS1 maint: discouraged parameter (link) "Sequential Tart: Anime ...
Chimera Music. 2013. No. 19.CS1 maint: others in cite AV media (notes) (link) Take Me to the Land of Hell (liner notes). Yoko ... Chimera Music. 2009. No.1.CS1 maint: others in cite AV media (notes) (link) The Flaming Lips with Yoko Ono/Plastic Ono Band ( ... Chimera Music. 2015. CHIM26.CS1 maint: others in cite AV media (notes) (link) Don't Stop Me! (liner notes). Yoko Ono/Plastic ... Chimera Music. 2009. PVCP-8259.CS1 maint: others in cite AV media (notes) (link) Happy Xmas (War is Over) (Sleeve). John & Yoko ...
CS1 maint: discouraged parameter (link) "Cyberpunk v3.0 Sneak Preview". Chimera Mag. Retrieved December 12, 2012. CS1 maint: ...
"Chimera") Odo. Quite young at 50 for a Changeling. He becomes Security Chief at Deep Space Nine. In a battle with a Changeling ...
"SOUNZ Chimera". "Napier Born Composer Appointed as Composer in Residence". Scoop. 6 January 2015. Retrieved 22 ... for trumpet and chamber orchestra Chimera (2013) a twelve minute work for solo organ and orchestra Piano Concerto No. 2 (2018) ...
Pulse (Audio CD, 2012) 1. Pulse 2. Sarabande 3. Carnaval 4. Arabesque 5. Mumbai Theme 6. Chimera 7. Asturias 8. Genesis 9. ...
Chimera Biotech. de la Rica, Roberto; Stevens, Molly M. (2012). "Plasmonic ELISA for the ultrasensitive detection of disease ...
"NCIS: Chimera". Retrieved 16 April 2019. "Cane , TV Guide". Retrieved 16 April 2019. "Graham McTavish". ...
Chimera Magazine". Chimera Magazine. 2018-05-15. Retrieved 2018-05-17. v t e. ...
Magazine, Chimera (July 6, 2018). "Roskilde- A Festival in Review". Chimera Magazine. Archived from the original on July 16, ...
Rivera, Jason (April 2000). "An Interview with: John Kricfalusi". Chimera (4). Archived from the original on May 17, 2005. ...
Chimera Publications. 21 June 2007. Retrieved 10 January 2021. "2008 Ditmar Awards". Swancon. Retrieved 9 January 2021. Harvey ... Chimaera Publications) Cat Sparks: Agog! Smashing Stories cover Les Petersen: Encounters Book Cover Les Petersen: cover and ...
... and Chimera for A12 (iOS 12, Sileo as the default package manager instead of Cydia) or Chimeras predecessor Electra(iOS 11). ... "Chimera". Retrieved June 4, 2019. "Electra". Retrieved March 4, 2019. "FrontPage API". junesiphone. ...
CS1 maint: discouraged parameter (link) "Fugue (Die Wende) , Chimera Arts". Retrieved 22 July 2020. CS1 maint ... CS1 maint: discouraged parameter (link) Chimera Arts Official website for Stephen W Tayler, Equa and The Noon Gun Stephen W. ...
Citing Chimera. Contact Us. Recent Citations. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing ... Chimera production release 1.12 is now available (64-bit builds for Windows, Mac, and Linux). See the release notes for details ... Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), supported in part by the National ... UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data ... .header { position: absolute; width: 230px; height: 80px; ...
Chimera Investment Corporation financial and business news, updates, and information from The New York Times and other leading ... Chimera Investment Corporation financial and business news, updates, and information from The New York Times and other leading ... News about Chimera Investment Corporation, including commentary and archival articles published in The New York Times. ...
Chimeras (album), a 2003 album by John Zorn Chimera, a 2002 album by The Cost Chimera, a 1974 album by Duncan Mackay Chimera, a ... Chimera (Aria album) (2001) Chimera (Delerium album), a 2003 album by Delerium Chimera (EP), a 2014 EP by Marié Digby Chimera ( ... Chimera, chimaera, or chimaira may refer to: Chimera (mythology), a monstrous creature with parts from multiple animals Mount ... Dragons Chimera Anima, a name grouping of animals in the anime Tokyo Mew Mew The Chimera, an alien race in Resistance Chimera ( ...
Strega Prize-winning La chimera (1990; The Chimera), perhaps taking a cue from historian Carlo Ginzburg as well as from ... Other articles where The Chimera is discussed: Italian literature: Fiction at the turn of the 21st century: … ... Strega Prize-winning La chimera (1990; The Chimera), perhaps taking a cue from historian Carlo Ginzburg as well as from ...
... chimaera: …unusual, hoe-shaped, flexible snout; and Rhinochimaeridae (long-nosed chimaeras), with an extended, pointed snout. ... Other articles where Long-nosed chimera is discussed: ... Long-nosed chimera. fish. THIS IS A DIRECTORY PAGE. Britannica ... In chimaera. …unusual, hoe-shaped, flexible snout; and Rhinochimaeridae (long-nosed chimaeras), with an extended, pointed snout ... ": { "url": "/animal/long-nosed-chimera", "shareUrl": "", "title": "Long- ...
For bugs in Chimera bookmark handling General For issues in Chimera that dont fit into other Chimera Components History For ... Product For issues in Chimera, the Mac OS X browser. Chimera uses Cocoazilla, a variant of Fizzilla that consists of a UNIX ... Page Layout For issues in Chimeras page layout. Preferences For issues in Chimera preferences. Toolbars & Menus For issues in ... I need a Chimera product created. I would be the default assignee for all components. Chris Petersen at Netscape can be the QA ...
Chimera (Ki-mira, ki-); a creation of the imagination, a wild fantasy... We publish erotic ebooks; fictional stories of ... This is the biography page for Chimera Books. ... Chimera Books. Publisher info Chimera (Ki-mira, ki-); a ... Chimera Books tag cloud. abduction sex alpha male alpha males bare bottom spanking barebottom spanking bdsm bdsm thriller ... You have subscribed to alerts for Chimera Books. You will receive an email alert if one or more of the authors youre following ...
2. chimera, chimaera, imagination, imaging, imagery, mental imagery. usage: a grotesque product of the imagination. WordNet 3.0 ... 1. Chimera, Chimaera, mythical monster, mythical creature. usage: (Greek mythology) fire-breathing female monster with a lions ...
CHIMERA by Wendy Lill, directed by Mary Vingoe, with Philippa Domville, David Fox and David Jansen. Presented by the Tarragon ( ... Chimera is not simply a thought-provoking orgy of ideas and character studies, Jansen notes. ... Politics and personal agendas collide in Chimera, Wendy Lills fast-paced political drama. The four-time Governor Generals ... the crusty journalist at the centre of the drama makes no apology for the fact that Chimera is an idea-driven play. ...
... the agile and lightweight Chimera is for trail aficionados ready to crush the miles. ... CHIMERA. $. Learn more. ", "UNAVAILABLE_MESSAGE":"Pay in 4 interest-free installments on purchases of $35-$1,000 with Details. ... Please enter your email so we can alert you when the CHIMERA in is back in stock. We promise not to spam you. You will only be ... With the Dyno Cinch System™ that allows for on-the-fly pack compression, the agile and lightweight Chimera is for trail ...
It prohibits "true" human-animal hybrids, but allows for so-called chimeras and cytoplasmic hybrid embryos. Any hybrid embryos ... Chimera bill: consultation begins (24 May 2007) ... Original URL: ...
Eupithecia chimera is a moth in the family Geometridae. It is found in Mexico. Yu, Dicky Sick Ki. "Eupithecia chimera (Dyar ... 2003). "Eupithecia chimera". The Global Lepidoptera Names Index. Natural History Museum. Retrieved May 3, 2018. v t e. ...
Nuclear dynamics in a fungal chimera. Marcus Roper, Anna Simonin, Patrick C. Hickey, Abby Leeder, and N. Louise Glass ... Moreover, chimera formation may be a driver for diversification at the species level by allowing lateral gene transfer between ... Dynamics of hH1-GFP and hH1-DsRed nuclear populations in a Neurospora crassa chimera. (A) Two homokaryotic mycelia, one with ... A fungal chimera must maintain its genetic richness during growth. Maintenance of richness is challenging because fungal ...
You are not logged in. If you sign up for an account, you can gain additional voting power over time, allowing your vote to have an even greater impact on submission scores! ...
According to press reports, Democrats in Congress are planning a major effort to reduce the so-called tax gap. This consists of money owed to the federal government but not paid. According to the Internal Revenue Service, in 2001 the gross tax gap was $345 billion, which fell to $290 billion after enforcement efforts. This suggests that about 14 percent of all taxes that are owed are not paid annually - a figure no higher today than in the 1980s.. These figures are primarily for individual income and payroll taxes - the IRS has not updated its research on corporate tax compliance for decades. One reason is that the line between tax evasion and legal tax avoidance in the corporate sector is very, very murky. For many corporations, its not worth the bother to evade taxes when there are so many legal tax avoidance opportunities available.. To a certain extent, this is true of individuals, as well. When I do radio shows, I often hear from callers who believe their taxes are much too high. But when ...
off gp120, the part of its protein coat that binds with the receptor molecule. In the past, scientists had thought that soluble CD4 alone might ...
β-1,4-glycanase (gold, Protein Data Bank entry 1exp) and cellobiohydrolase I (cyan, Protein Data Bank entry 1cel) have different folds but a similar pattern of amino acids near a glucose residue. This possible example of convergent evolution was identifed in Table 5 of ...
Home The Chimera Fetus Sculpture: A Strange But Cool Gift Chimera-fetus ...
That mess is titled Chimera.. Chimera follows scientist Quint (Henry Ian Cusick) who is decoding the DNA of the Turritopsis ... Chimera is bloody well acted and looks beautiful, but it is all in service of a superficial and didactic story. Thestory ... Chimera constantly has the characters assert exactly where they stand on every issue that comes up from science versus religion ... Chimera (2018) Directed by Maurice Haeems. Written by Maurice Haeems. Starring Henry Ian Cusick, Kathleen Quinlan, Erika Ervin ...
Chimera. Period:. Six Dynasties (220-589). Date:. 5th century. Culture:. China. Medium:. Stone. Dimensions:. H. 21 1/2 in. ( ... Chimera Artist: Date: 5th century. Accession Number: 63.224.1 Date: 5th century Medium: Stone Accession: 63.224.1 On view in: ...
Good job. I like your attention to detail by showing the fishs reflection in the puddle of water. The strewn out dead figure adds some nice effect to the obviously already suffering fish. It could use more of a background than just white but maybe fishboy is just resting on a white table.. ...
XCOM: Chimera Squad Announced, Coming to Steam This Month. XCOM: Chimera Squad is an XCOM 2 follow-up that offers its own story ... XCOM: Chimera Squad - Zero Punctuation. This week on Zero Punctuation, Yahtzee reviews XCOM: Chimera Squad. Want to watch Zero ...
... human-mouse chimeras, human-pig chimeras and human-chimpanzee chimeras. A chimera is an organism with components of at least ... Also, certain chimeras would be banned such as human-primate chimeras and any animal chimera in which a human brain would ... The resulting chimera was destroyed a few days later. Chimeras are even being produced right here in the United States. Esmail ... The patent debate extends beyond human chimeras themselves to other biotechnological innovations necessary to making chimeras, ...
This page includes Chimeras : cover picture, songs / tracks list, members/musicians and line-up, different releases details, ... Chimera is a music studio album recording by DUNCAN MACKAY (Symphonic Prog/Progressive Rock) released in 1974 on cd, lp / vinyl ... Anyway I dont count it as a proper part of "Chimera" at all. I can summarize this review saying that "Chimera" is a really ... CHIMERA. Duncan Mackay. • Symphonic Prog. From, the ultimate progressive rock music website. ...
Thank you all for helping others here at StackOverflow #SOreadytohelp!. Software Engineer. Most experience is in writing C for embedded systems. Have experience with C#, PIC assembler, Visual Basic, Pascal and Fortran.. I enjoy electronics, cars and hang gliding.. ...
Jonathan Butlers optimistic music belies a dirt-poor childhood growing up in a South Africa segregated by apartheid. Live in South Africa, a new CD and DVD package, presents a sense of the resulting inner turmoil, mixed with dogged resolve, that paved the way to his status as an icon in his country and successful musician outside of it. Looking back, the 46-year-old Butler says today, the driving forces that led to his overcoming apartheid-the formal policy of racial separation and economic discrimination finally dismantled in 1993-were family, faith and abundant talent.. "When we were kids, our parents never talked about the ANC [African National Congress] or Nelson Mandela," he says. Butler was raised as the youngest child in a large family. They lived in a house patched together by corrugated tin and cardboard, in the "coloreds only" township of Athlone near Cape Town. "They never talked about struggles so we never knew what was happening ...
Every week we ask our students to review how they are progressing with our program.. Weve got questions, and theyve got answers!. Read Our Reviews ...
... shares of Chimera Investment Corp (Symbol: CIM) were. ... Chimera Investment Corp (Symbol: CIM) is a member of the ... In the case of Chimera Investment Corp, looking at the history chart for CIM below can help in judging whether the most recent ... Looking at the universe of stocks we cover at Dividend Channel , in trading on Thursday, shares of Chimera Investment Corp ( ...
Hi, I am trying to install Chimera on phpbb 3.1.x the support team has told me before I bought it that it works on 3.1.x but I ... the smartest thing to do is post in the phpbb3 forum for chimera, posting in the free forums will not lead to a quick answer to ... Re: Chimera and phpbb 3.1.x Posted 3 years 3 months ago ... Re: Chimera and phpbb 3.1.x Posted 3 years 3 months ago ...
  • The terrible secret they are trying to get to the bottom of is shrouded in the legend of a mythical creature, Chimera. (
  • It prohibits "true" human-animal hybrids, but allows for so-called chimeras and cytoplasmic hybrid embryos. (
  • Newman's 1997 application was entitled "Chimeric Embryos and Animals Containing Human Cells" and described, among other things, human-mouse chimeras, human-pig chimeras and human-chimpanzee chimeras. (
  • Chimeras contain two or more genetically distinct cell populations and can be made by fusing embryos from different species or transplanting embryonic cells from one species into the developing embryo of another. (
  • Most people didn't care deeply in the 1960s when Beatrice Mintz combined embryos from two different mice to create a chimera, nor in the 1980s, when Nicole Le Douarin combined chick and quail embryos. (
  • Chimeras are formed from four parent cells (two fertilized eggs or early embryos fuse together) or from three parent cells (a fertilized egg is fused with an unfertilized egg or a fertilized egg is fused with an extra sperm). (
  • Efforts to create human-animal chimeras have rebooted an ethical debate after reports emerged that scientists have produced monkey embryos containing human cells. (
  • UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. (
  • UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera. (
  • UCSF Chimera--a visualization system for exploratory research and analysis. (
  • Three new species of the genus Chimaera Linnaeus (Chimaeriformes: Chimaeridae) from Australia. (
  • A chimera is an organism with components of at least two separate species that could not naturally mate. (
  • Such an organism is called a tetragametic chimera as it is formed from four gametes - two eggs and two sperm . (
  • As the organism develops, the resulting chimera can come to possess organs that have different sets of chromosomes . (
  • A chimera is an organism whose cells come from two or more "individuals," with recent work looking at combinations from different species. (
  • Not to be confused with a species of chimaera - the Rabbitfish ( Chimaera monstrosa ). (
  • The prize is a solo exhibition at the Chimera-Project Gallery (Opening: October 28, 2016). (
  • In Greek mythology the 'Chimaera' was a monstrous fire-breathing hybrid creature. (
  • One of the most iconic monsters of the classical world, in Greek mythology the chimera was a hybrid beast, a four-legged creature with the forequarters of a lion and the hindquarters of a dragon, with a goat's head grafted onto its central trunk. (
  • Moreover, chimera formation may be a driver for diversification at the species level by allowing lateral gene transfer between strains that are too distantly related to hybridize sexually. (
  • Undetected chimeras may be misinterpreted as novel species, causing inflated estimates of diversity and spurious inferences of differences between populations. (
  • Bioethical and policy discussions have instead largely focused on responses to laboratory creations of cross-species combinations that lead to chimeras, hybrids, or genetics mosaics. (
  • To date, 50 species of chimaera have been recorded worldwide. (
  • Like skates and some species of shark, chimaera reproduce by laying eggs. (
  • Some chimaera species are widespread. (
  • But once caught many chimaera species don't survive, due to being hauled up from such depths. (
  • As a deep-sea species, chimaera are at further risk from deep-sea trawling. (
  • UCHIME either uses a database of chimera-free sequences or detects chimeras de novo by exploiting abundance data. (
  • Researchers at the Salk Institute created the mouse/human chimera and found that their livers responded much like a human's when exposed to hepatitis B and C, a pair of diseases that has attracted considerable interest from emerging biotech companies. (
  • The latest report, published in the Spanish newspaper El Pais, claims a team of researchers led by Juan Carlos Izpis Belmonte from the Salk Institute in the US have produced monkey-human chimeras. (
  • Chimeras speak with three overlapping voices, but rarely do so, typically only when playing toady to a more powerful creature. (
  • It has so many and such varied features that each one gains its own embellishment, until the creature becomes an epic tapestry of monstrous menace and brutal hatred, ideas which in and of themselves are not entirely divorced from the reality of the chimera, regardless of how inaccurate the specifics may be. (
  • A century after the publication of the H.G. Wells classic, Stuart Newman filed a controversial U.S. patent application directed to human-animal chimeras. (
  • More recently, a human-rabbit chimera was produced in China by fusing human skin cells and rabbit embryo cells. (
  • Rather, he was seeking to establish precedent to prevent others from filing and obtaining patents directed to human chimeras. (
  • Has anyone tried StemCell's new product for enriching for murine/human chimeras? (
  • The result was taken as intriguing and a little science fictionlike, and it generated discussion of what it would mean if somebody could create human or human-animal chimeras. (
  • The United States didn't enact any new policies, though bioethics consultants in the U.S. report that people often feel queasy about creating "unnatural" laboratory human chimeras, for a mix of practical and ethical reasons. (
  • It's the highest level of human cells in a chimera yet, and a major step toward a new medical reality. (
  • Scientists have created a human-mouse chimera with 4 percent human cells-the most of any chimera to date. (
  • Scientists at the University at Buffalo and the Roswell Park Cancer Institute have bred a new form of human-mouse chimera with the highest incidence of human cells ever recorded. (
  • Chimeras are organisms made up of a mixture of genetically different tissues-in this case, mouse cells and human stem cells. (
  • Because this study represents the highest level of human cells in a chimera yet, it's a momentous leap toward that version of medical reality. (
  • But even as a human Chimera, Taylor's case is a rare and fascinating one, because while most Chimeras only display the symptoms internally or have very small skin marks, Muhl's stomach is split down the middle into two skin tones. (
  • Genetically engineered human-animal chimeras - what could go wrong? (
  • Pig-human and sheep-human chimeras are attractive in part because pigs and sheep have organs about the right size for transplantation into humans. (
  • However, Alejandro De Los Angeles, from the department of psychiatry at Yale University, said it was likely that monkey-human chimeras were being developed to explore how to improve the proportion of human cells in such organisms. (
  • Making human-monkey chimeras could teach us how to make human-pig chimeras with the hope of making organs for transplantation. (
  • De Los Angeles pointed out that, as with previous work in pigs and sheep, the human-monkey chimeras have reportedly only been allowed to develop for a few weeks - ie, before organs actually form. (
  • The news of the monkey-human chimeras came shortly after it was reported that Japanese researchers, including Hiromitsu Nakauchi, received government support to create mouse-human chimeras. (
  • 200 ng/ml of this Chimera induces ERK1 and ERK2 phosphorylation in human umbilical vein endothelial (HUVEC) cells. (
  • Reader Tom Alves called my attention to the singer Taylor Muhl, a human chimera . (
  • Sometimes human chimeras are detected through paternity tests: a woman's somatic cells, which are sampled to get her genotype, might be from one zygote, while her ovaries, which produce the eggs, could be from another. (
  • and the younger ones, who had not yet met with such good fortune, thought it a shame to have lived so long without getting astride of a flying serpent, or sticking their spears into a Chimaera , or, at least, thrusting their right arms down a monstrous lion's throat. (
  • Chimeras are monstrous creatures born of primordial evil. (
  • Last December, Chinese researchers created two monkey-pig chimeras after genetically modifying cynomolgus monkey cells in culture. (
  • Two unusual extensions are presented: Multiscale, which adds the ability to visualize large-scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera session interactively despite being at separate locales. (
  • Nonetheless, lingering in the back of even the most cynical individuals' minds is the knowledge that whatever the chimera is, it must be a truly horrifying beast to garner such extravagant fables. (
  • Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), supported in part by the National Institutes of Health (P41-GM103311). (
  • Chimera is segmented into a core that provides basic services and visualization, and extensions that provide most higher level functionality. (
  • This week on Zero Punctuation, Yahtzee reviews XCOM: Chimera Squad. (
  • XCOM: Chimera Squad is an XCOM 2 follow-up that offers its own story and more of the series's famous turn-based gameplay. (
  • Chimera Squad is a fun, bite-size spin-off of the XCOM series that scales down the scope and stakes. (
  • XCOM: Chimera Squad, on the other hand, is a friendlier, more accessible XCOM game. (
  • XCOM: Chimera Squad lacks the general brutality of the mainline PC games , but it still scratches that strategy itch. (
  • While Gears Tactics translates the third-person shooter franchise into a strategy game to solid genre-shifting success, Chimera Squad shaves away some of the XCOM series' denser aspects, keeping the genre but making it a bit more accessible. (
  • Chimera Squad takes place several years after XCOM 2 and its expansions. (
  • A three-way chimeric alignment is constructed, and a chimera is reported if its score [Equation ()] exceeds a preset threshold. (
  • Chimera follows scientist Quint (Henry Ian Cusick) who is decoding the DNA of the Turritopsis jellyfish. (
  • Dynamics of hH1-GFP and hH1-DsRed nuclear populations in a Neurospora crassa chimera. (
  • Its name has become a byword among doubters, skeptics, and naysayers, who refer to anything that seems impossible, fanciful, or overly embellished as chimerical, for surely nothing in the world could possibly be all the dubious things perpetuators of the chimera myth claim the monster to be. (
  • The tension between the tremendous medical value of certain chimeras and the ethical issues have made the patentability and legality of creating such animals a hotly debated topic. (
  • That's somewhat reassuring, since chimeras with the ability to reproduce could become an ethical nightmare. (
  • Get the Deluxe Edition of 'Cellar Door', featuring the 160-page hardcover with a Kickstarter-exclusive bookplate signed by all the creators, PLUS a full digital download audio commentary by Carmelo Chimera giving you the complete behind the scenes of each story. (
  • When that harmony is disrupted by a terrorist attack, XCOM's Chimera Squad is sent in to assist the city's police as a strike force designed to deal with violent threats. (
  • It is called Mount Chimera after a fire-breathing beast of ancient legend. (
  • Rumors, myths, fireside stories, and travelers' tales fill in gaps about what a chimera might be or what it could do, and none seem impossible or unlikely for a beast of such bizarre qualities. (
  • CHIMERA INCARNATE is the stunning conclusion to the Karen Wilson Chronicles. (
  • News about Chimera Investment Corporation, including commentary and archival articles published in The New York Times. (
  • I need a Chimera product created. (
  • Product For issues in Chimera, the Mac OS X browser. (
  • Chimera uses Cocoazilla, a variant of Fizzilla that consists of a UNIX back end wed to a Cocoa front end Bookmarks For bugs in Chimera bookmark handling General For issues in Chimera that don't fit into other Chimera Components History For issues in Chimera History. (
  • Variant of Chimera . (
  • 2. Variant of chimera . (
  • Chimeras could grow transplant organs and help find cures for diseases, but are we willing to accept the result of such efforts? (
  • Chimeras are seen as a potential way to address the lack of organs for transplantation, as well as problems of organ rejection. (
  • But it's different when the chimera occurs naturally. (
  • Chimera constantly has the characters assert exactly where they stand on every issue that comes up from science versus religion to work versus family to wealth versus barely making ends meet. (
  • In this expressive carousel, constantly pursuing the guiding image of the chimera, the designer orchestrates intriguing implanted figures, amplified by the use of an innovative ceramic surface finishing technique. (
  • Like sharks, chimaera use electroreception to find their prey in the dark. (
  • You'r e probably wondering why anyone would want to buy a chimera fetus, but I'm sure there are plenty of oddballs like me out there who find this pretty damn cool. (
  • Chimera by definition means a couple of things. (
  • However, tPR recognises the chimera in the room and has not come out in favour of a specific definition. (
  • Hi, I am trying to install Chimera on phpbb 3.1.x the support team has told me before I bought it that it works on 3.1.x but I cannot see it in the install part of styles after I uplaoded the style. (
  • Today, Cannes Lions is out with the creative brief for its Cannes Chimera Initiative, a competition which aims to inspire creatives to create "innovative communications concepts that can help build public awareness and support for solutions to critical global development problems. (
  • For example, the chimera may have a liver composed of cells with one set of chromosomes and have a kidney composed of cells with a second set of chromosomes. (
  • Recently though (pre-Safari) I made the move to Chimera. (
  • To all who touched the code of Chimera and Camino -- you made lives better. (
  • Put another way, the chimera is formed from the merger of two fraternal twins in a very early (zygote or blastocyst) phase. (
  • Doctors say that the model absorbed her fraternal twin while in the womb, and parts of its DNA now exist in her body, making her a Chimera, of which there are only 100 known cases in the whole world. (
  • Gandalf of the Marmosets, Emperor Marmoset, Saguinus imperator Animals that carry cells from another individual, most often a fraternal twin (non-identical), are known as chimeras. (
  • However, he added that if chimeras were allowed to develop further, it could raise concerns. (
  • The long time forgotten keyboardist DUNCAN MCKAY has at last been added to Prog Archives database by the Symphonic Team, so it's time to review his 1974 release "Chimera", an impressive work with great music but sadly almost unknown, due to the hard competition of the early 70's. (
  • Chimeras, while certainly in a nascent stage of scientific exploration-and a controversial one, too, as detractors think of the work as "playing God" -hold significant promise. (
  • Associated with the general ideal of combining initially incongruous parts, the term chimera refers - also in biological and zoological terms - to a fusion between units that originates a new identity, which provides an almost perfect description of the decorative inspiration behind the ceramic collection carrying this name designed by Elena Salmistraro. (
  • NEW YORK--( BUSINESS WIRE )--The Board of Directors of Chimera Investment Corporation announced the declaration of its first quarter cash dividend of $0.30 per common share. (
  • The Board of Directors of Chimera announced the declaration of its first quarter cash dividend of $0.50 per share of 8% Series A Cumulative Redeemable Preferred Stock. (
  • These are the words which open Chimera , a new short film by Sam Guest and Julia Baylis . (
  • Please enter your email so we can alert you when the CHIMERA in is back in stock. (
  • In other parts of the world chimaera may be kept as 'valued bycatch' or discarded back into the sea. (
  • Around the world chimaera are directly targeted by a small number of fisheries. (
  • A discussion of the usage of Chimera in real-world situations is given, along with anticipated future directions. (
  • a chimera of the pensions world? (