Chikungunya virus: A species of ALPHAVIRUS causing an acute dengue-like fever.Alphavirus Infections: Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.Reunion: One of the Indian Ocean Islands, east of Madagascar. Its capital is Saint-Denis. It was discovered in 1507 by the Portuguese and claimed by France in 1638. It was first colonized in 1662 as Isle de Bourbon but renamed Reunion in 1793. In 1946 it was made an overseas department of France. The name commemorates the reunion of the revolutionaries from Marseilles with the National Guard in Paris in 1792. (From Webster's New Geographical Dictionary, 1988, p1011; Room, Brewer's Dictionary of Names, 1992, p454; French Embassy)Aedes: A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.Indian Ocean Islands: Numerous islands in the Indian Ocean situated east of Madagascar, north to the Arabian Sea and east to Sri Lanka. Included are COMOROS (republic), MADAGASCAR (republic), Maldives (republic), MAURITIUS (parliamentary democracy), Pemba (administered by Tanzania), REUNION (a department of France), and SEYCHELLES (republic).Comoros: A group of Indian Ocean Islands, the islands of Great Comoro, Anjouan, Mayotte, and Moheli, lying between northeast Mozambique and northwest Madagascar. The capital is Moroni. In 1914 they became a colony attached to Madagascar administratively and were made a French overseas territory in 1947. Except for Mayotte which remained French, Comoros became an independent republic in 1975. Comoros represents the Arabic qamar, moon, said by some scholars to be linked with the mystical Mountains of the Moon said to be somewhere in equatorial Africa. (From Webster's New Geographical Dictionary, 1988, p283 & Room, Brewer's Dictionary of Names, 1992, p122)Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.Insect Vectors: Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Alphavirus: A genus of TOGAVIRIDAE, also known as Group A arboviruses, serologically related to each other but not to other Togaviridae. The viruses are transmitted by mosquitoes. The type species is the SINDBIS VIRUS.Arbovirus Infections: Infections caused by arthropod-borne viruses, general or unspecified.Indian Ocean: A body of water covering approximately one-fifth of the total ocean area of the earth, extending amidst Africa in the west, Australia in the east, Asia in the north, and Antarctica in the south. Including the Red Sea and the Persian Gulf, it constitutes the third largest ocean after the ATLANTIC OCEAN and the PACIFIC OCEAN. (New Encyclopaedia Britannica Micropaedia, 15th ed, 1990, p289)Ross River virus: A species of ALPHAVIRUS associated with epidemic EXANTHEMA and polyarthritis in Australia.Culicidae: A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.Africa, Central: The geographical area of Africa comprising CAMEROON; CENTRAL AFRICAN REPUBLIC; CHAD; CONGO; EQUATORIAL GUINEA; GABON; and DEMOCRATIC REPUBLIC OF THE CONGO.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Communicable Diseases, Emerging: Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.Africa, Eastern: The geographical area of Africa comprising BURUNDI; DJIBOUTI; ETHIOPIA; KENYA; RWANDA; SOMALIA; SUDAN; TANZANIA; and UGANDA.Arboviruses: Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Travel: Aspects of health and disease related to travel.Arthralgia: Pain in the joint.Dengue: An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.Sindbis Virus: The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.IndiaPhylogeny: The relationships of groups of organisms as reflected by their genetic makeup.RNA Viruses: Viruses whose genetic material is RNA.Malaysia: A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Dengue Virus: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.Angola: A republic in southern Africa, southwest of DEMOCRATIC REPUBLIC OF THE CONGO and west of ZAMBIA. Its capital is Luanda.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Vaccinia virus: The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.Gabon: A republic in west equatorial Africa, south of CAMEROON and west of the CONGO. Its capital is Libreville.Disease Vectors: Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.Host Specificity: The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.Virus Cultivation: Process of growing viruses in live animals, plants, or cultured cells.Viremia: The presence of viruses in the blood.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Air Conditioning: The maintenance of certain aspects of the environment within a defined space to facilitate the function of that space; aspects controlled include air temperature and motion, radiant heat level, moisture, and concentration of pollutants such as dust, microorganisms, and gases. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Epidemics: Sudden outbreaks of a disease in a country or region not previously recognized in that area, or a rapid increase in the number of new cases of a previous existing endemic disease. Epidemics can also refer to outbreaks of disease in animal or plant populations.Virology: The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksEncephalomyelitis, Western Equine: A form of arboviral encephalitis (which primarily affects horses) endemic to western and central regions of NORTH AMERICA. The causative organism (ENCEPHALOMYELITIS VIRUS, WESTERN EQUINE) may be transferred to humans via the bite of mosquitoes (CULEX tarsalis and others). Clinical manifestations include headache and influenza-like symptoms followed by alterations in mentation, SEIZURES, and COMA. DEATH occurs in a minority of cases. Survivors may recover fully or be left with residual neurologic dysfunction, including PARKINSONISM, POSTENCEPHALITIC. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-9)FloridaTolonium Chloride: A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.Criminology: The study of crime and criminals with special reference to the personality factors and social conditions leading toward, or away from crime.Bathing Beaches: Beaches, both natural and man-made, used for bathing and other activities.

Vectors of Chikungunya virus in Senegal: current data and transmission cycles. (1/380)

Chikungunya fever is a viral disease transmitted to human beings by Aedes genus mosquitoes. From 1972 to 1986 in Kedougou, Senegal, 178 Chikungunya virus strains were isolated from gallery forest mosquitoes, with most of them isolated from Ae. furcifer-taylori (129 strains), Ae. luteocephalus (27 strains), and Ae. dalzieli (12 strains). The characteristics of the sylvatic transmission cycle are a circulation periodicity with silent intervals that last approximately three years. Few epidemics of this disease have been reported in Senegal. The most recent one occurred in 1996 in Kaffrine where two Chikungunya virus strains were isolated from Ae. aegypti. The retrospective analysis of viral isolates from mosquitoes, wild vertebrates, and humans allowed to us to characterize Chikungunya virus transmission cycles in Senegal and to compare them with those of yellow fever virus.  (+info)

Comparison of PanBio dengue duo enzyme-linked immunosorbent assay (ELISA) and MRL dengue fever virus immunoglobulin M capture ELISA for diagnosis of dengue virus infections in Southeast Asia. (2/380)

The performances of the MRL dengue fever virus immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) and the PanBio Dengue Duo IgM capture and IgG capture ELISA were compared. Eighty sera from patients with dengue virus infections, 24 sera from patients with Japanese encephalitis (JE), and 78 sera from patients with nonflavivirus infections, such as malaria, typhoid, leptospirosis, and scrub typhus, were used. The MRL test showed superior sensitivity for dengue virus infections (94 versus 89%), while the PanBio test showed superior specificity for JE (79 versus 25%) and other infections (100 versus 91%). The PanBio ELISA showed better overall performance, as assessed by the sum of sensitivity and specificity (F value). When dengue virus and nonflavivirus infections were compared, F values of 189 and 185 were obtained for the PanBio and MRL tests, respectively, while when dengue virus infections and JE were compared, F values of 168 and 119 were obtained. The results obtained with individual sera in the PanBio and MRL IgM ELISAs showed good correlation, but this analysis revealed that the cutoff value of the MRL test was set well below that of the PanBio test. Comparing the sensitivity and specificity of the tests at different cutoff values (receiver-operator analysis) revealed that the MRL and PanBio IgM ELISAs performed similarly in distinguishing dengue virus from nonflavivirus infections, although the PanBio IgM ELISA showed significantly better distinction between dengue virus infections and JE. The implications of these findings for the laboratory diagnosis of dengue are discussed.  (+info)

Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. (3/380)

Chikungunya (CHIK) virus is a member of the genus Alphavirus in the family TOGAVIRIDAE: Serologically, it is most closely related to o'nyong-nyong (ONN) virus and is a member of the Semliki Forest antigenic complex. CHIK virus is believed to be enzootic throughout much of Africa and historical evidence indicates that it spread to other parts of the world from this origin. Strains from Africa and Asia are reported to differ biologically, indicating that distinct lineages may exist. To examine the relatedness of CHIK and ONN viruses using genetic data, we conducted phylogenetic studies on isolates obtained throughout Africa and Southeast Asia. Analyses revealed that ONN virus is indeed distinct from CHIK viruses, and these viruses probably diverged thousands of years ago. Two distinct CHIK virus lineages were delineated, one containing all isolates from western Africa and the second comprising all southern and East African strains, as well as isolates from Asia. Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa and subsequently was introduced into Asia. Within the eastern Africa and southern Africa/Asia lineage, Asian strains grouped together in a genotype distinct from the African groups. These different geographical genotypes exhibit differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquito vectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with AE: furcifer and AE: africanus mosquitoes.  (+info)

Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218. (4/380)

We conducted a phase II, randomized, double-blind, placebo-controlled, safety and immunogenicity study of a serially passaged, plaque-purified live chikungunya (CHIK) vaccine in 73 healthy adult volunteers. Fifty-nine volunteers were immunized one time subcutaneously with the CHIK vaccine and 14 were immunized with placebo (tissue culture fluid). Vaccinees were clinically evaluated intensively for one month, and had repeated blood draws for serological assays (50% plaque-reduction neutralization test) for one year. Except for transient arthralgia in five CHIK vaccinees, the number and severity of local and systemic reactions and abnormal laboratory tests after immunization were similar in CHIK vaccinees and placebo recipients. Fifty-seven (98%) of 58 evaluable CHIK vaccinees developed CHIK neutralizing antibody by day 28, and 85% of vaccinees remained seropositive at one year after immunization. No placebo recipients seroconverted. This promising live vaccine was safe, produced well-tolerated side effects, and was highly immunogenic.  (+info)

Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site. (5/380)

In this study, the complete genomic sequence of chikungunya virus (CHIK; S27 African prototype) was determined and the presence of an internal polyadenylation [I-poly(A)] site was confirmed within the 3' non-translated region (NTR) of this strain. The complete genome was 11805 nucleotides in length, excluding the 5' cap nucleotide, an I-poly(A) tract and the 3' poly(A) tail. It comprised two long open reading frames that encoded the non-structural (2474 amino acids) and structural polyproteins (1244 amino acids). The genetic location of the non-structural and structural proteins was predicted by comparing the deduced amino acid sequences with the known cleavage sites of other alphaviruses, located at the C-terminal region of their virus-encoded proteins. In addition, predicted secondary structures were identified within the 5' NTR and repeated sequence elements (RSEs) within the 3' NTR. Amino acid sequence homologies, phylogenetic analysis of non-structural and structural proteins and characteristic RSEs revealed that although CHIK is closely related to o'nyong-nyong virus, it is in fact a distinct virus. The existence of I-poly(A) fragments with different lengths (e.g. 19, 36, 43, 91, 94 and 106 adenine nucleotides) at identical initiation positions for each clone strongly suggests that the polymerase of the alphaviruses has a capacity to create poly(A) by a template-dependant mechanism such as 'polymerase slippage', as has been reported for vesicular stomatitis virus.  (+info)

Effect of temperature stress on immature stages and susceptibility of Aedes aegypti mosquitoes to chikungunya virus. (6/380)

A high temperature stress of 44.5 degrees C for 10 minutes on the larval stages was found to affect the susceptibility of adult Aedes aegypti mosquitoes to chikungunya virus. At this temperature, the mortality of the mosquito larvae was found to be approximately 95%, whereas a temperature greater than 45 degrees C for 10 minutes was found to be lethal. A temperature tolerant (TT) strain was developed by exposing the larvae to a temperature of 44.5 degrees C for 10 minutes at every generation for five generations. This strain was established to determine whether increase in the susceptibility was due to any selection pressure of higher temperature or to the influence of other intrinsic factors such as expression of immunoresponsive (IR) genes. Other studies on these mosquito strains showed that when maintained at 28 +/- 1 degrees C, there was no difference in the larval duration and mortality in the immature stages, but the mean survival of female mosquitoes in the TT strain was 5-6 days longer. Conversely, when mosquitoes were maintained throughout at 37 degrees C the mean survival of the mosquitoes decreased drastically in both strains, but the mean survival of females in the TT strain was 5-6 days longer compared with the unstressed controls. This increases the probability of at least one more blood meal. Fecundity of the TT strain was found to be lower than that of the control mosquitoes. Data suggest that expression of certain IR genes was affected by the heat shock. Some of these genes were up-regulated and down-regulated, which may have affected the susceptibility of mosquitoes to the virus. Although there was some selection in the temperature-tolerant individuals in the TT strain, when stressed by heat they showed expression of IR genes in a pattern similar to that in the normal controls. It appears that an increase in temperature above the average temperature of an area might help increase the proportion of virus-susceptible mosquitoes in the population. Such an increase in temperature in an endemic area would not only enhance the selection of temperature-tolerant individuals in a population having more longevity, but would also affect both intrinsic and extrinsic factors by reducing the extrinsic incubation period and increasing susceptibility of mosquitoes to viruses due to affected expression of IR genes.  (+info)

Differential infectivities of o'nyong-nyong and chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes. (7/380)

O'nyong-nyong virus (ONNV) and chikungunya virus (CHIKV) are closely related alphaviruses that cause human disease in Africa and Asia. Like most alphaviruses, CHIKV is vectored by culicine mosquitoes. ONNV is considered unusual as it primarily infects anopheline mosquitoes; however, there are relatively few experimental data to support this. In this study, three strains of ONNV and one strain of CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes and in four cell lines. As predicted, CHIKV was not infectious to An. gambiae, and we observed strain-variability for ONNV with respect to the ability of the virus to infect An. gambiae and Ae. aegypti. The species specificity in vivo was reflected by in vitro experiments using culicine and anopheline-derived cell lines.  (+info)

Determinants of vector specificity of o'nyong nyong and chikungunya viruses in Anopheles and Aedes mosquitoes. (8/380)

The alphaviruses o'nyong nyong virus (ONNV) and chikungunya virus (CHIKV) provide a unique system to study the viral genes involved in vector specificity. ONNV infects both anopheline and culicine mosquitoes, whereas CHIKV infects only culicine mosquitoes. In this study, chimeric viruses were constructed that contained genes from both ONNV and CHIKV. These chimeras and previously described full-length infectious clones of ONNV and CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes. Virus derived from the infectious clones of ONNV and CHIKV retained the vector specificity of the parental viruses. All six of the chimeras were found to infect Ae. aegypti mosquitoes at high rates but only the chimera containing viral genes encoding all of the structural proteins of ONNV was able to infect An. gambiae mosquitoes. These data indicate that all of the viral structural proteins are necessary for ONNV to infect An. gambiae mosquitoes.  (+info)

*Sabin Vaccine Institute

Dipali Pathak (30 August 2016). "Grant to develop chikungunya virus vaccine awarded". Baylor College of Medicine. Archived from ...

*Prohibitin

Human prohibitin 1 has some activity as a virus receptor protein, having been identified as a receptor for Chikungunya Virus ( ... "Identification of prohibitin as a Chikungunya virus receptor protein". Journal of Medical Virology. 84 (11): 1757-70. doi: ... CHIKV) and Dengue Virus 2 (DENV-2). Little else is known about the activity of the prohibitins in viral pathogenesis. ...

*Chikungunya

In a nonhuman primate model, chikungunya virus was found to persist in the spleen for at least six weeks. Chikungunya virus ( ... The chikungunya virus is passed to humans when a bite from an infected mosquito breaks the skin and introduces the virus into ... Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint pain. These typically ... Viruses portal Chikungunya fact sheet-from WHO World Health Organization Chikungunya outbreaks-from WHO World Health ...

*Malir Town

"Aedes aegypti mosquito responsible for Chikungunya virus in Karachi: report". Dunya News tv. December 21, 2016. Retrieved ... as thousands of patients were affected by mysterious Chikungunya virus in December, 2016. Despite joint denial by WHO and ... Provincial Government of Sindh discloses that aedes aegypti mosquito is responsible for spreading Chikungunya in the area. ... "More patients arrive at Karachi hospital with symptoms of mysterious virus". Geo News tv. Retrieved December 21, 2016. " ...

*Zika virus outbreak timeline

Epidemiology of chikungunya Viruses portal United Nations portal Gatherer, Derek; Kohl, Alain (2016). "Zika virus: a previously ... chikungunya and Zika virus infections - an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014". ... "Zika virus infection - Venezuela". Disease Outbreak News. WHO. 3 December 2015. Retrieved 20 June 2016. "Zika Virus in the ... "Zika virus infection - El Salvador". Disease Outbreak News. WHO. March 2016. Retrieved 20 June 2016. "Zika virus infection - ...

*2014 CFU Women's Caribbean Cup

Notes: Guadeloupe withdrew before the tournament due to outbreak of chikungunya virus. Cuba v Suriname Haiti v Suriname Haiti v ... Notes: Anguilla withdrew before the tournament due to outbreak of chikungunya virus. Dominican Republic v Saint Lucia Saint ...

*O'nyong'nyong virus

ONNV is a togavirus (family Togaviridae), genus Alphavirus, is closely related to the chikungunya and Igbo Ora viruses, and is ... The o'nyong'nyong virus (ONNV) was first isolated by researchers at the Uganda Virus Research Institute in Entebbe, Uganda, ... along with chikungunya virus. ONNV has at least three major subtypes, or strains, the genomic sequences of which are currently ... "High Rates of O'Nyong Nyong and Chikungunya Virus Transmission in Coastal Kenya". PLOS Neglected Tropical Diseases. 9 (2): ...

*Mosquito-borne disease

Examples are the Zika virus, chikungunya virus, yellow fever and dengue fever. The re-emergence of the viruses has been at a ... Laboratory blood tests can identify evidence of chikungunya or other similar viruses such as dengue and Zika. Blood test may ... "Testing for Zika Virus". CDC. 2017-08-30. Retrieved 2017-10-01. "Chikungunya". World Health Organization. Retrieved 2017-10-01 ... PMC 5290000 . Goupil, Brad A; Mores, Christopher N (November 30, 2016). "A Review of Chikungunya Virus-induced Arthralgia: ...

*Neglected tropical diseases

The virus was first isolated from an outbreak in Tanzania in 1952. Chikungunya virus is a member of the genus Alphavirus and ... viruses (dengue and chikungunya, rabies). The World Health Organization recognizes the seventeen diseases below as neglected ... The word chikungunya is from the Makonde which means "that which bends up," and this refers to the effect of the debilitating ... There are 50-100 million dengue virus infections annually. Dengue fever is usually not fatal, but infection with one of four ...

*Makonde language

"Four cases of acute flaccid paralysis associated with chikungunya virus infection". Epidemiol Infect. 136: 1277-80. doi:10.1017 ... "Chikungunya at the Door - Déjà Vu All Over Again?". New England Journal of Medicine. 371: 885-887. doi:10.1056/NEJMp1408509. ... The Matembwe and Mabiha (Maviha) dialects are divergent, and may not be Makonde (Nurse 2003). Chikungunya, the name of a ...

*Anguilla women's national football team

Anguilla withdrew before the start of the competition due to the outbreak of Chikungunya virus. This means that Anguilla's last ...

*Aedes furcifer

Yellow fever, chikungunya, Zika, Bouboui and Bunyamwera viruses have been isolated from members of the furcifer group. Ae. ... Jupp, PG; McIntosh, BM (1990). "Aedes furcifer and other mosquitoes as vectors of chikungunya virus at Mica, northeastern ... and is a vector of chikungunya virus. Aedes furcifer feeds readily on monkeys and humans and has been observed to enter ... Diallo, D; Sall, AA; Diagne, CT; Faye, O; Faye, O; Ba, Y; Hanley, KA; Buenemann, M; Weaver, SC; Diallo, M (2014). "Zika virus ...

*Healthcare in Nicaragua

"Viremia and Clinical Presentation in Nicaraguan Patients Infected With Zika Virus, Chikungunya Virus, and Dengue Virus". ... The chikunguya, dengue, and Zika viruses co-circulate in Nicaragua, and those infected with one or multiple of these viruses ...

*Aedes cordellieri

Jupp, PG; McIntosh, BM (1990). "Aedes furcifer and other mosquitoes as vectors of chikungunya virus at Mica, northeastern ... have been demonstrated to be capable of transmitting yellow fever virus through bites under laboratory conditions. Yiau-Min ...

*Aedes aegypti

Values for both locations were seen to be similar to those found for dengue and Chikungunya virus. Determining these values ... Signs of Zika virus-capable mosquito populations have been found adapting for persistence in warm temperate climates. Such a ... "Dengue Virus: Vector And Transmission". Retrieved 19 October 2012. "Lay Your Eggs Here". Newswise, Inc. July 3, 2008. Retrieved ... Aedes aegypti, the yellow fever mosquito, is a mosquito that can spread dengue fever, chikungunya, Zika fever, Mayaro and ...

*Hepatocyte growth factor

HGF may further play a role as an indicator for prognosis of chronicity for Chikungunya virus induced arthralgia. High HGF ... "Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony ...

*Virus-like particle

More recently, VLPs were used to develop a pre-clinical vaccine against chikungunya virus. Research suggests that VLP vaccines ... March 2010). "A VLP vaccine for epidemic Chikungunya virus protects non-human primates against infection". Nature Medicine. 16 ... Virus-like particles resemble viruses, but are non-infectious because they contain no viral genetic material. The expression of ... "Ebola Virus-like Particles Prevent Lethal Ebola Virus Infection" (PDF). United States Army Medical Research Institute of ...

*Mayaro virus disease

... such as Ross River virus, chikungunya, Sindbis virus, and O'nyong'nyong virus. Receveur MC, Grandadam M, Pistone T, Malvy D ( ... Chikungunya virus is closely related, producing a nearly indistinguishable, highly debilitating arthralgic disease. On February ... Mayaro Virus has a structure similar to other Alphavirus. It is an enveloped virus and has an icosahedral capsid with a ... Infection with Mayaro virus causes an acute, self-limited dengue-like illness of 3-5 days' duration. The causative virus, ...

*Ross River virus

... caused by Chikungunya virus. The Australian disease seemed to progress in milder fashion. In 1956, serological testing ... The new virus was named Ross River virus, and the disease Ross River fever. The virus itself was first isolated in 1972 using ... Ross River fever is also known as Ross River virus infection or Ross River virus disease. The Ross River virus is named after ... Taxonomically, Ross River virus belongs to the virus genus Alphavirus, which is part of the family Togaviridae. The ...

*Natural killer cell

Chikungunya virus, HIV, or viral hepatitis. However, whether these virus infections trigger the expansion of adaptive NKG2C+ NK ... Patients deficient in NK cells prove to be highly susceptible to early phases of herpes virus infection. For NK cells to defend ... The distinction between apoptosis and cell lysis is important in immunology: lysing a virus-infected cell could potentially ... "Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis Virus ...

*Macrophage

... caused by CHIKV or Chikungunya virus). Adenovirus (most common cause of pink eye) can remain latent in a host macrophage, with ... Like T cells, macrophages can be infected with HIV, and even become a reservoir of ongoing virus replication throughout the ... Infection of macrophages in joints is associated with local inflammation during and after the acute phase of Chikungunya ( ... ISBN 0-8385-8529-9. CS1 maint: Extra text: authors list (link) "Chikungunya Disease: Infection-Associated Markers from the ...

*Eilat virus

Researchers at the University of Texas Medical Branch used this concept for the Chikungunya virus by creating the UTMB test. ... related viruses (by super infection exclusion/ Homologous interference). This in turn will allow the virus to form a virus ,(of ... Alphavirus Mosquito-borne Anopheles Chikungunya Sindbis virus Positive sense Nasar, Farooq; Palacios, Gustavo; Gorchakov, ... Therefore, with further study the Eilat virus can compensate in making clear the viral factors other pathogenic similar viruses ...

*Ivermectin

... is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever. A 2012 ... Feb 2016). "Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses". ...

*J. Christopher Kovats-Bernat

... the chikungunya virus, amoebic dysentery, giardia, leptospirosis; he was once overcome with a swarm of hornets that invaded his ...

*Julie Ledgerwood

Chikungunya, and other emerging infectious diseases. She led the first human trial aimed at testing a vaccine for Ebola virus. ... "Experimental Vaccine For Chikungunya Passes First Test". NPR.org. Retrieved 2016-03-09. Grady, Denise (2009-12-21). "Case of ... www.nbcnews.com/storyline/ebola-virus-outbreak/first-human-ebola-vaccine-trial-shows-it-seems-work-n256196 Interview, "Q&A: ... "Could a new vaccine offer protection against chikungunya virus," Medical News Today, http://www.medicalnewstoday.com/articles/ ...

*Rocky Mountain spotted fever

Differential diagnosis includes dengue, leptospirosis, and, most recently, chikungunya and Zika virus infections. Appropriate ... the organism smaller than a bacterium and larger than a virus) that causes this disease. He and others characterized the basic ...
The European Centre for Disease Prevention and Control issued a risk assessment on the ongoing outbreak of chikungunya virus infection in Italy. Two r...
The Mississippi State Department of Health has confirmed a number of cases of chikungunya virus infection in Mississippi residents recently returned from Haiti and the Dominican Republic. Other possible cases are under investigation. Mississippians who travel to the Dominican Republic, Haiti, Puerto Rico or other Caribbean countries are at risk of chikungunya virus. Chikungunya can spread from person to person through the bite of a mosquito once travelers return home. See protective measures for travelers ». ...
Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of viral genome into the host cytoplasm for replication. How the E1 structure determines membrane fusion and whether other CHIKV structural proteins participate in E1 fusion activity remain largely unexplored. A bicistronic baculovirus expression system to produce recombinant baculoviruses for cell-based assay was used. Sf21 insect cells infected by recombinant baculoviruses bearing wild type or single-amino-acid substitution of CHIKV E1 and EGFP (enhanced green fluorescence protein) were employed to investigate the roles of four E1 amino acid residues (G91, V178, A226, and H230) in membrane fusion activity. Western blot analysis revealed that the E1 expression level and surface features in wild type and mutant substituted cells were similar. However, cell fusion assay found that those cells infected by
Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of viral genome into the host cytoplasm for replication. How the E1 structure determines membrane fusion and whether other CHIKV structural proteins participate in E1 fusion activity remain largely unexplored. A bicistronic baculovirus expression system to produce recombinant baculoviruses for cell-based assay was used. Sf21 insect cells infected by recombinant baculoviruses bearing wild type or single-amino-acid substitution of CHIKV E1 and EGFP (enhanced green fluorescence protein) were employed to investigate the roles of four E1 amino acid residues (G91, V178, A226, and H230) in membrane fusion activity. Western blot analysis revealed that the E1 expression level and surface features in wild type and mutant substituted cells were similar. However, cell fusion assay found that those cells infected by
Inthukantham Kashaya and Vilvadi Gulika are the medicines that can be taken as preventive measures of chikungunya .Ayurveda suggests carrot and sunflower seeds as good supplements for chikungunya patients as they strengthen persons resistance to fight disease. Triphala, an ayurvedic composition of Harada, Amla and Behada and dry seedless grapes are also effective in controlling symptoms of chikungunya. Ayurvedic treatment for bringing relief from various symptoms of chikungunya include: Fever in Chikunguya: Sacred Basil (Tulsi) leaves are very effective in reducing chikungunya fever. Vilvadi Gulika, Amritarishta and Sudarsanam Gulika are the other commonly prescribed ayurvedic medicines for fighting the fever. Muscle and Joint Pain in Chikungunya The patients of chikungunya face severe joint and muscle pain. This pain can even persist from months to years. Useful ayurvedic medications for controlling pain in chikungunya include: ...
Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. We herein analysed the innate immune response (cytokine and programmed cell death) of RAW264.7 mouse macrophages following CHIKV infection. We found that the infection was restrained to a small percentage of cells and was not associated with a robust type I IFN innate immune response (IFN-α4 and ISG56). TNF-α, IL-6 and GM-CSF expression were upregulated while IFN-γ, IL-1α, IL-2, IL-4, IL-5, IL-10 or IL-17 expression could not be evidenced prior to and after CHIKV exposure. Although CHIKV is known to drive apoptosis in many cell types, we found no canonical signs of programmed cell death (cleaved caspase-3, -9) in infected RAW264.7 cells. These data argue for the capacity of CHIKV to infect and drive a specific innate immune response in RAW264.7 macrophage cell which seems
Another name for Chikungunya Disease is Chikungunya Disease. What is Chikungunya disease? A person with Chikungunya disease has an infection caused by ...
Author Summary Chikungunya virus (CHIKV) is transmitted by mosquito bites and causes a febrile disease that is often characterized by persistent joint pain. Until recently, CHIKV outbreaks were limited to tropical areas of Africa and Asia. However, since 2007, following a large CHIKV epidemic in the Indian Ocean and South-East Asia, CHIKV has also been reported in temperate European regions. As mosquito habitats expand, virus dissemination may become more prevalent, but there are currently no vaccines or CHIKV-specific treatments available. We previously described two human antibodies that potently block cellular CHIKV infection. In the current report, we have characterized CHIKV mutants that escape neutralization to identify sub-domains of the virus envelope which are involved in CHIKV interaction with these antibodies, thereby opening the door for the development of CHIKV-specific sub-domain vaccination strategies. For the first time, we have also demonstrated that CHIKV can be directly transmitted
In 2005-6, more than 1.5 million people in the Indian Ocean area were infected with Chikungunya fever. In Reunion Island, 38.3% of the population, approximately 300 000 people, were infected.1 Only 6% of the cases were asymptomatic. Chikungunya fever is a viral infection transmitted to humans by Aedes mosquitoes.2,3 Chikungunya infection usually causes a syndrome characterised by fever, headaches, chills, conjunctivitis, rash, myalgia and severe joint pain with or without swelling. Joint symptoms vary from polyarthralgia to symmetrical polyarthritis. The outcome is usually benign, but persistent joint pain and stiffness may occur.3,4,5,6,7,8. We report 21 cases … ...
The Cook Islands Ministry of Health has confirmed seven cases of chikungunya on Rarotonga since November 2014, in which three of the cases were considered locally acquired.. Local transmission means that mosquitoes in the area have been infected with chikungunya and are spreading it to people.. CDC recommends that travelers to the Cook Islands protect themselves from mosquito bites. Some travelers may be more likely to get chikungunya, have severe disease, or be at higher risk for other reasons. CDC advises travelers in high-risk groups to discuss their travel plans with their health care provider.. Chikungunya is a viral disease transmitted by the bite of infected mosquitoes such as Aedes aegypti and Aedes albopictus. It can cause high fever, join and muscle pain, and headache. Chikungunya does not often result in death, but the joint pain may last for months or years and may become a cause of chronic pain and disability.. There is no specific treatment for chikungunya infection, nor any ...
Their newest investigation analyzed recent events in chikungunya virus evolution that will aid in predicting future trends in transmission and circulation that determine epidemic potential. Weaver and his team found that the initial adaption provided the framework for a second wave of adaptations that can enable rapid diversification of viral strains and even more efficient transmission to people. In addition, analysis of the chikungunya virus strain expressing a combination of the second-wave adaptive mutations revealed a similar pattern of changes and heightened adaptive qualities suggesting the future emergence of even higher transmission efficiency. ...
Abstract Five species of mosquito were studied to compare their susceptibility to infection, ability to sustain infection, and vector efficiency over a 4- to 5-week period after being infected with an African strain of chikungunya virus. Aedes triseriatus and Aedes albopictus were readily infected with the virus and maintained the highest infection and transmission rates of the mosquitoes tested during the test period. Aedes togoi also maintained a very high infection rate, but was a poor transmitter. Eretmapodites chrysogaster exhibited fairly high infection rates throughout the test and relatively high transmission rates in the latter half of the 35-day test period. Surprisingly low infection and transmission rates were found for Aedes aegypti.
BioCollections Worldwide said today that it is now offering a laboratory-developed test for the detection of Chikungunya virus. The assay follows the US Centers for Disease Control and Preventions real-time RT-PCR protocol for detection of Chikungunya virus, and detects cases in the acute stage of infection in about five hours, BCW said. The Miami-based company is providing the test through its CLIA-certified testing laboratory.
...Recent breakthroughs in Chikungunya research spearheaded by scientists...Chikungunya fever caused by the Chikungunya virus (CHIKV) is a mosq...CHIKV infection is characterised by an abrupt onset of fever frequentl...To devise strategies to stop CHIKV transmission Dr Ngs team collabor...,Breakthroughs,in,Chikungunya,research,from,A*STAR,spell,new,hope,for,better,treatment,and,protection,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
MANHASSET, NY - Lindsay Lohan getting the mosquito-transmitted virus Chikungunya may help shine a light on the seriousness of the virus, according to a New York infectious disease physician.. "There is an epidemic of the virus in the Caribbean and a few cases in Florida," says Bruce Hirsch, MD, attending infectious disease physician at North Shore University Hospital in Manhasset.. Ms. Lohan contracted the virus while on vacation in French Polynesia.. "Doctors hope her celebrity status reminds us of the importance of learning and preventing emerging health concerns," Dr. Hirsch says. "The Chikungunya virus causes fever and arthritis. Older persons with the virus can have painful arthritis for long periods.". In addition to fever and arthritis, some symptoms of Chikungunya include:. ...
Chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes albopictus and Aedes aegypti mosquitoes in tropical areas of Africa, Asia, and the islands of the Indian Ocean. In 2007 and 2009, CHIKV was transmitted outside these tropical areas and caused geographically localized infections in people in Italy and France. To temporally and spatially characterize CHIKV infection of Ae. albopictus midguts, a comparison of viral distribution in mosquitoes infected per os or by enema was conducted. Ae. albopictus infected with CHIKV LR 5′ green fluorescent protein (GFP) at a titer 10[superscript 6.95] tissue culture infective dose[subscript 50] (TCID[subscript 50])/mL, were collected and analyzed for virus dissemination by visualizing GFP expression and titration up to 14 days post inoculation (dpi). Additionally, midguts were dissected from the mosquitoes and imaged by fluorescence microscopy for comparison of midgut infection patterns between orally- and enema-infected mosquitoes. When virus was ...
The reemergence of Chikungunya virus exemplifies the need to develop new vaccines to target other emerging viral pathogens. Chikungunya is estimated to be responsible for several million human infections in the last decade. In addition, one of its vectors, the Aedes albopictus mosquito, is moving into new regions, meaning the infection rate is expected to…
Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same |i|Aedes|/i| mosquito vectors and thus overlap in their endemic areas. These two viruses also cause similar clinical presentations, especially in the initial stages of infection, with neither virus possessing any specific distinguishing clinical features. Because the outcomes and management strategies for these two viruses are vastly different, early and accurate diagnosis is imperative. Diagnosis is also important for surveillance, outbreak control, and research related to vaccine and drug development. Available diagnostic tests are aimed at detection of the virus, its antigenic components, or the host immune antibody response. In this review, we describe the recent progress and continued challenges related to the diagnosis of DENV and CHIKV infections.
Q: I heard there was a new viral disease from Africa that has just come to the Americas. What is this?A: It sounds like you are referring to the chikungunya virus.Chikungunya (which means stooped walk in a Tanzanian language, named because the joint pain from it makes people walk in a bent over fashion) is a viral illness transmitted by infected mosquitoes (only certain types of mosquitoes can carry this virus). The cycle of infection is: a mosquito bites a person (or certain animals) that
Q: I heard there is a new viral disease from Africa that has just come to the Americas. What is this?A: It sounds like you are referring to the chikungunya virus.Chikungunya (which means stooped walk in a Tanzanian language; named because the joint pain from it makes people walk in a bent-over fashion) is a viral illness transmitted by infected mosquitoes (only certain types of mosquitoes can carry this virus). The cycle of infection is: a mosquito bites a person (or certain
Florida case is unusual. Hirschwerk said he and his colleagues diagnosed chikungunya fever virus within the past six weeks. The Long Island patients were unrelated, he said.. "One of those cases has been confirmed by the CDC," Hirschwerk said, "and testing is still pending on the others.. "The likelihood of having more cases in individuals who have not traveled is very low," Hirschwerk said. "The Florida case is unusual and I dont expect to see high numbers [of infections] but we have to keep an eye on the situation.". For some experts, the emergence of chikungunya in Florida sounds an alarm because the virus is carried by mosquito species -- Aedes albopictus and Aedes aegypti-- that are well established in this country.. "The two species of Aedes mosquitoes that spread chikungunya are found in the southern and eastern United States," said Dr. Erin Staples, a medical epidemiologist at the CDC.. "It is difficult to predict how the disease will spread in the mainland U.S.," Staples said, "but we ...
Chikungunya fever is a mosquito-borne febrile illness caused by Chikungunya virus (CHIKV), an alphavirus from the Togaviridae family. It is transmitted by primarily Aedes aegytpi and Aedes albopictus mosquitos [1]. Once of little importance in the Am ...
Author Summary Dengue and chikungunya are mosquito-borne diseases that are found in similar geographical areas and present with similar symptoms. As their treatment is different, especially for dengue haemorraghic fever (DHF) which is a more severe form of dengue, it is important for healthcare workers to differentiate between them. We studied 117 chikungunya and 917 dengue adult patients (including 55 with DHF) by comparing their clinical presentation and developed decision trees to classify them using simple symptoms and laboratory tests. From the study, we found that at their first appearance in hospital, more chikungunya patients had muscle or joint pains, and fewer had a sore throat, cough, nausea, vomiting, diarrhea, stomach pain, loss of appetite or fast heart beat than DF or DHF patients. From the decision trees, of DF versus chikungunya using only platelet level cut-offs, we could correctly classify 89% of the cases. For DHF versus chikungunya using platelet level cut-offs and the presence of
Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the development of vaccine candidates is of critical importance. Historically, live-attenuated vaccines (LAVs) for protection against arthropod-borne viruses have been created by blind cell culture passage leading to attenuation of disease, while maintaining immunogenicity. Attenuation may occur via multiple mechanisms. However, all examined arbovirus LAVs have in common the acquisition of positively charged amino acid substitutions in cell-surface attachment proteins that render virus infection partially dependent upon heparan sulfate (HS), a ubiquitously expressed sulfated polysaccharide, and appear to attenuate by retarding dissemination of virus particles in vivo. We previously reported that, like other ...
Chikungunya causes, symptoms, prevention and treatment in Hindi. चिकनगुनिया का कारण, लक्षण, फैलाव और चिकित्सा की जानकारी. Chikungunya ke dard ka upchar, Chikungunya kaise hota hai. Chikungunya ka gharelu upchar. Chikungunya treatment in Hindi.
Chikungunya virus (CHIKV) is an arthropod-borne agent that causes severe arthritic disease in humans and is considered a serious health threat in areas where competent mosquito vectors are prevalent. CHIKV has recently been responsible for several millions of cases of disease, involving over 40 countries. The recent re-emergence of CHIKV and its potential threat to human health has stimulated interest in better understanding of the biology and pathogenesis of the virus, and requirement for improved treatment, prevention and control measures. In this study, we mapped the binding sites of a panel of eleven monoclonal antibodies (mAbs) previously generated towards the capsid protein (CP) of CHIKV. Using N- and C-terminally truncated recombinant forms of the CHIKV CP, two putative binding regions, between residues 1-35 and 140-210, were identified. Competitive binding also revealed that five of the CP-specific mAbs recognized a series of overlapping epitopes in the latter domain. We also identified a
Chikungunya virus (CHIKV) is a mosquito-transmitted, single-stranded RNA alphavirus of the Togaviridae family that causes explosive epidemics of a severe febril...
The nsP2 protease of chikungunya virus (CHIKV) is one of the essential components of viral replication and it plays a crucial role in the cleavage of polyprotein precursors for the viral replication process. Therefore, it is gaining attention as a potential drug design target against CHIKV. Based on the recently determined crystal structure of the nsP2 protease of CHIKV, this study identified potential inhibitors of the virus using structure-based approaches with a combination of molecular docking, virtual screening and molecular dynamics (MD) simulations. The top hit compounds from database searching, using the NCI Diversity Set II, with targeting at five potential binding sites of the nsP2 protease, were identified by blind dockings and focused dockings. These complexes were then subjected to MD simulations to investigate the stability and flexibility of the complexes and to gain a more detailed insight into the interactions between the compounds and the enzyme. The hydrogen bonds and hydrophobic
This is a Phase I, open-label, dose-escalation study to examine the safety, tolerability, and immune response to a Virus-Like Particle (VLP) Chikungunya Virus (CHIKV) vaccine in healthy adults ages 18 to 50 years old. The plan is for 25 subjects to receive 3 intramuscular vaccine injections at weeks 0, 4, and 20. The three groups will be enrolled sequentially starting with the lowest dose of 10 micrograms per injection in Group 1.. The hypothesis is that the vaccine is safe and induces immune responses to CHIKV. The primary objective is to evaluate the safety and tolerability of the investigational vaccine, VRC-CHKVLP059-00-VP, at three dosages, 10 micrograms (mcg), 20 mcg, and 40 mcg, in healthy adults. The secondary objective is to evaluate the antibody response against CHIKV VLPs four weeks after the third vaccine injection. The exploratory objectives relate to antigen-specific humoral and cellular immune responses throughout the study. ...
Abstract. Chikungunya virus (CHIKV) is an emerging, mosquito-borne alphavirus that has caused major epidemics in Africa and Asia. We developed chimeric vaccine candidates using the non-structural protein genes of either Venezuelan equine encephalitis virus (VEEV) attenuated vaccine strain TC-83 or a naturally attenuated strain of eastern equine encephalitis virus (EEEV) and the structural genes of CHIKV. Because the transmission of genetically modified live vaccine strains is undesirable because of the potentially unpredictable evolution of these viruses as well as the potential for reversion, we evaluated the ability of these vaccines to infect the urban CHIKV vectors, Aedes aegypti and Ae. albopictus. Both vaccine candidates exhibited significantly lower infection and dissemination rates compared with the parent alphaviruses. Intrathoracic inoculations indicated that reduced infectivity was mediated by midgut infection barriers in both species. These results indicate a low potential for transmission
Public health officials in Florida on Thursday confirmed that two people in the state contracted the mosquito-borne chikungunya virus locally, rather than overseas.
1. DomingoE 2010 Mechanisms of viral emergence. Vet Res 41 38. 2. NijhuisMvan MaarseveenNMBoucherCA 2009 Antiviral resistance and impact on viral replication capacity: evolution of viruses under antiviral pressure occurs in three phases. Handb Exp Pharmacol 299 320. 3. ParrishCRKawaokaY 2005 The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu Rev Microbiol 59 553 586. 4. ZhangCYWeiJFHeSH 2006 Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups. BMC Microbiol 6 88. 5. BraultACPowersAMOrtizDEstrada-FrancoJGNavarro-LopezR 2004 Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein. Proc Natl Acad Sci U S A 101 11344 11349. 6. TsetsarkinKAVanlandinghamDLMcGeeCEHiggsS 2007 A single mutation in chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 3 ...
Researchers have developed a new candidate vaccine to protect against chikungunya virus, a mosquito-borne pathogen that produces an intensely painful and often chronic arthritic disease that has stricken millions of people in India, Southeast Asia and Africa.
As of April 7, 2015, a total of 77 chikungunya virus disease cases have been reported to ArboNET from 21 U.S. states for 2015 (Table 1 & Map). All reported cases occurred in travelers returning from affected areas. No locally-transmitted cases have been reported from U.S. states ...
Dr Richard Gair, the Director of Tropical Public Health Services in Queensland, joined the program to explain. via Chikungunya virus - ABC Queensland - Australian Broadcasting Corporation (ABC).
The history of Chikungunya outbreak in India dates back to 1824 whereas the virus was first isolated in 1963 from Kolkata. 4 The viral activity in humans have been observed till 1971......The present outbreak in India started during December 2005 where the country has so far experienced more than 11,00,000 (11 lakh) of Chikungunya infected cases which still continues. 6 The cases were first reported from Andhra Pradesh, one of the worst affected states. Subsequently reports were poured in from several districts of Karnataka, Kerala, Maharashtra , Orissa, Madhya Pradesh, and Tamil Nadu. Even Andaman experienced the first Chikungunya epidemic during June 2006. Presently the outbreak is underway in western parts of India specially Gujarat and Rajasthan ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Réunion Island (Indian Ocean) has been suffering from its first known Chikungunya virus (CHIKV) epidemic since February 2005. To achieve a better understanding of the disease, a questionnaire was drawn up for hospital staff members and their household. CHIKV infected about one-third of the studied population, the proportion increasing with age and being higher in women. Presence of a garden was associated with CHIKV infection. The geographical distribution of cases was concordant with insect vector Aedes albopictus distribution. The main clinical signs were arthralgia and fever. The disease evolved towards full recovery in 34·4% of cases, a relapse in 55·6%, or a chronic form in 10%. Paracetamol was used as a painkiller in 95% of cases, sometimes associated with non-steroidal anti-inflammatory drugs, corticoids, or traditional herbal medicine. The survey provided valuable information on the factors that favour transmission, the clinical signs, the importance of relapses and the therapies used.
In May 2008, a 32 year old Indian male patient presented with chief complaints of a high fever with erythema on ear, severe polyarthritic joint pains & swelling, non pitting pedal oedema, facial puffiness and itching for four days in a Chikungunya viral epidemic outbreak declared region of South Canara district, Karnataka, India. He had no significant past medical and drug history. He had no history of smoking. The patients BMI was 21.6 kg/m2, Blood Pressure was 110/70 mmHg, Pulse rate was 98/min and Respiratory rate was 16/min with no signs of dehydration. The clinical examination of the Respiratory, Cardiovascular, Gastrointestinal and Neurological systems was unremarkable. A provisional clinical diagnosis of Chikungunya was made.. IgM antibody specific to Chikungunya virus was detected using MAC-ELISA. Blood counts revealed leucopenia (2000 cells/micro litre) along with lymphopenia (500cells/Micro litres). The peripheral smear also revealed lymphocytopenia, with the differential lymphocyte ...
Signs of Chikungunya including medical signs and symptoms of Chikungunya, symptoms, misdiagnosis, tests, common medical issues, duration, and the correct diagnosis for Chikungunya signs or Chikungunya symptoms.
chikungunya fever: Viral disease transmitted to humans by infected mosquitoes that is characterized by fever, headache, rash, and severe joint and muscle pain. The name chikungunya, which means
Doctors help you with trusted information about Fever in Chikungunya: Dr. Isaacs on how to cure chikungunya fever: Fever is usually a symptom of infection. If you think you just have a mild illness like the common cold or a simple viral cough then it is probably safe treat the symptoms and see how you go. Medicines like paracetamol and ibuprofen can be effective at lowering your temperature which may make you feel better but wont make you get better faster. Remember to drink plenty of water and rest!
After the bite of an infected mosquito, onset of illness occurs usually between 4 and 8 days, but can range from 2 to 12 days. Chikungunya is characterized by an abrupt onset of fever frequently accompanied by joint pain. Other common signs and symptoms include muscle pain, headache, nausea, fatigue and rash. The joint pain is often very debilitating, but usually lasts for a few days or may be prolonged to weeks. Hence the virus can cause acute, subacute, or chronic disease. Most patients recover fully, but in some cases joint pain may persist for several months, or even years. Occasional cases of eye, neurological, and heart complications have been reported, as well as gastrointestinal complaints. Serious complications are not common, but in older people, the disease can contribute to the cause of death. Often symptoms in infected individuals are mild and the infection may go unrecognized, or be misdiagnosed in areas where dengue occurs. Co-infections of dengue and chikungunya can occur ...
Chikungunya virus (CHIKV) is an arbovirus capable of causing a severe and often debilitating rheumatic syndrome in humans. CHIKV replicates in a wide variety of cell types in mammals, which has made attributing pathologic outcomes to replication at specific sites difficult. To assess the contribution of CHIKV replication in skeletal muscle cells to pathogenesis, we engineered a CHIKV strain exhibiting restricted replication in these cells via incorporation of target sequences for skeletal muscle cell-specific miR-206. This virus, which we term SKE, displayed diminished replication in skeletal muscle cells in a mouse model of CHIKV disease. Mice infected with SKE developed less severe disease signs, including diminished swelling in the inoculated foot and less necrosis and inflammation in the interosseous muscles. SKE infection was associated with diminished infiltration of T cells into the interosseous muscle as well as decreased production of Il1b, Il6, Ip10, and Tnfa transcripts. Importantly, ...
Chikungunya virus (CHIKV) is an arbovirus capable of causing a severe and often debilitating rheumatic syndrome in humans. CHIKV replicates in a wide variety of cell types in mammals, which has made attributing pathologic outcomes to replication at specific sites difficult. To assess the contribution of CHIKV replication in skeletal muscle cells to pathogenesis, we engineered a CHIKV strain exhibiting restricted replication in these cells via incorporation of target sequences for skeletal muscle cell-specific miR-206. This virus, which we term SKE, displayed diminished replication in skeletal muscle cells in a mouse model of CHIKV disease. Mice infected with SKE developed less severe disease signs, including diminished swelling in the inoculated foot and less necrosis and inflammation in the interosseous muscles. SKE infection was associated with diminished infiltration of T cells into the interosseous muscle as well as decreased production of Il1b, Il6, Ip10, and Tnfa transcripts. Importantly, ...
Chikungunya: Virus Chikungunya is a mosquito-borne alpha virus that was first isolated after a 1952 outbreak in modern-day Tanzania .A number of chikungunya outbreaks is due to the change in the genetic sequence which altered the viral coat protein which allows it to multiply more easily in the mosquito cells. The virus uses Asian tiger mosquito (invasive vector ) and the main vector being Aedes aegypti. Precautions need to be taken to stop the growth of the vector to combat the virus spread.. In 2006 there was a large outbreak in India . The virus re-emerged in 2006 after a gap of 32 years and caused an explosive outbreak affecting 13 states. The states first affected were Andhra Pradesh, Karnataka, Maharashtra, Madhya Pradesh, Tamil Nadu, Gujarat and Kerala. The tropical environment of India aids in the mosquito growth and hence spread of the virus.. Now in the year 2016 the outbreak in Delhi and regions near to Delhi is large. According to the Department of Microbiology at AIIMS, 712 samples ...
A promising prophylactic vaccine candidate against chikungunya fever will be tested from August on in a phase II clinical study in Puerto Rico, a chikungunya fever endemic area. Developed by the Austrian biotech company Themis Bioscience GmbH the live attenuated vaccine is considered as one of the most advanced candidates globally. It is based on a standard measles vaccination vector that offers an excellent immunogenicity and safety profile. The vaccine candidate already showed high seroconversion rates in the preceding phase I clinical trial: Up to 100 percent of all vaccinated subjects produced neutralizing antibodies against the chikungunya virus. Currently the vaccine candidate is tested in two parallel phase II studies in both, the USA and Austria/Germany. The additional trial in Puerto Rico is intended to evaluate the influence of previous chikungunya infections on the safety and immunogenicity of the vaccine candidate ...
Emergent BioSolutions Inc. EBS announced that the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) has granted PRIority Medicines (PRIME) designation to its chikungunya vaccine candidate CHIKV VLP.
A total of 96 people have died of the mosquito-bourne Chikungunya disease in Indias southern Kerala state, news reports said on Sunday. Five more deaths were reported on Saturday from the worst-hit Alappuzha district, a prime tourism destination for its backwaters, the Hindustan Times newspaper reported.. Chikungunya has come back to Kerala after 30 years, PA Joshi, director of the National Vector Control Programme, was quoted as saying. The outbreak of the viral disease was first detected in the state in July.. More than 100,000 people were reported to have been affected in Kerala, most of them in Alappuzha district, federal Health Ministry officials said.. Cases of chikungunya had also been reported from national capital Delhi, the northern state of Rajasthan and eastern West Bengal.. Meanwhile, the current outbreak of dengue, another mosquito-bourne disease, spread across the country with over 3,000 cases reported from 12 of Indias 29 states.. More than 45 people have died of dengue so ...
Goh LY, Hobson-Peters J, Prow NA, Gardner J, Bielefeldt-Ohmann H, Suhrbier A, Hall RA. (2015) Monoclonal antibodies specific for the capsid protein of chikungunya virus suitable for multiple applications. J Gen Virol. 96:507-12. Goh LY, Hobson-Peters J, Prow NA, Baker K, Piyasena TB, Taylor CT, Rana A, Hastie ML, Gorman JJ, Hall RA. (2015) The Chikungunya Virus Capsid Protein Contains Linear B Cell Epitopes in the N- and C-Terminal Regions that are Dependent on an Intact C-Terminus for Antibody Recognition. Viruses. 8;7:2943-64.. Taylor A, Liu X, Zaid A, Goh LY, Hobson-Peters J, Hall RA, Merits A, Mahalingam S. (2017) Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design. mBio. 21;8(1).. For technical enquiries, please email [email protected] THIS MATERIAL IS FOR RESEARCH USE ONLY AND CANNOT BE USED FOR CLINICAL OR DIAGNOSTIC PURPOSES. To discuss opportunities relating to commercial use of these materials, please contact UniQuest Pty Ltd. to ...
The genus Alphavirus is one of two within the family Togaviridae and comprises approximately 30 species, including several pathogens of humans and other animals that are of medical, veterinary and economic importance. Most alphaviruses are maintained in nature by a biological transmission cycle between susceptible vertebrate hosts and blood-feeding arthropods such as mosquitoes. In common with many Old World alphavirus pathogens Chikungunya virus (CHIKV) is the aetiological agent of a syndrome characterized by fever, skin rash and acute or chronic poly-arthralgia or arthritis. Whereas previously CHIKV outbreaks were sporadic and self-limiting, in 2004 it re-emerged in coastal Kenya and there followed a series of outbreaks that have continued until the present day, resulting in many millions of cases. Inroads into understanding the pathogenesis of CHIKV disease were until recently hampered through the lack of a convenient small animal model capable of exhibiting symptoms similar to those observed ...
Researchers at Baylor College of Medicine are recruiting volunteers for a vaccine trial to test the safety and immune responses to a vaccine against chikungunya virus.
Chikungunya is a viral disease that is rarely fatal and is transmitted to humans by infected mosquitoes. Symptoms of chikungunya include high fever and headache, with significant pains in the joints (ankles, wrists), which can persist for several weeks.. The symptoms appear between 4 and 7 days after the patient has been bitten by an infected mosquito. The name, chikungunya derives from a word in Makonde language roughly meaning "that which bends up", reflecting the physique of a person suffering from the disease. ...
Some effective home remedies for chikungunya pain and other symptoms can be very useful for the patients. Since no preventive vaccine or anti-viral drug has been developed for curing this condition hence chikungunya home remedies helps in curing fast
Honduras was a false alarm, so these seem to be the first confirmed chikungunya cases in Central America. Via Prensa Latina: Panamá detecta dos casos de chikungunya y declara alerta preventiva.[Panama detects two chikungunya cases and declares a preventive alert]...
Health officials in Brevard County in Florida have identified a new case of the mosquito-borne chikungunya disease, raising the number of known cases the state has seen this year to 19.
The basic cause of Chikungunya nausea in people is due to the bite of tainted and spiteful flying creepy crawlers. Chikungunya nausea is a disease that generally remains for a couple or months or it might be cured in weeks. There is not at all any particular vaccine or any antiviral remedy discovered for this malicious disease right now.
Autochthonous Chikungunya Fever in Traveler Returning to Japan from Cuba To the Editor: Chikungunya fever is a febrile illness caused by mosquito-transmitted chikungunya virus CHIKV: (genus Alphavirus, family Togaviridae). Clinical signs and symptoms typically begin with high-grade fever after an incubation period of 2-4 days (1). Other common symptoms include polyarthralgia, which is usually symmetric […] Continue reading → ...
According to Taiwan News, the 29-year-old Filipino male was detected with fever upon his arrival at Kaohsiung International Airport on Jan. 2. He was then referred to a hospital for treatment by the airport quarantine section. A blood test later revealed that he was infected with the chikungunya virus.. According to the CDCs epidemiological investigation, the Filipino flew alone to Taiwan for contract work in Tainan, which neighbors Kaohsiung. It was his first time in the country, the CDC said.. The prompt action by health authorities resulted to prevention of spread of the virus to the rest of the community, the CDC said, noting that the man was discharged from the hospital on Monday in good health. Since chikungunya was listed as a notifiable infectious disease in Taiwan in October 2007, there have been 106 confirmed cases in the country, all of them originating abroad. A total of 91 percent originated in Southeast Asia, including 57 cases from Indonesia and 24 cases from the Philippines, CDC ...
Via Emerging Infectious Diseases: Chikungunya in the Caribbean-Threat for Europe. Excerpt: The first evidence of chikungunya virus in the Western Hemisphere was its detection in December 2013 in the French West Indies (1). One month later, the virus spread to...
The Institute of Life Sciences (ILS), which functions under the Department of Biotechnology, has entered into a non-exclusive license for product commercialisation after having successfully developed antibodies against the Chikungunya viral (CHIKV).
Marylanders are urged to be wary of mosquito-borne diseases like West Nile Virus, and now, chikungunya after that virus was reported in a Florida man, according to the CDC.
Mexico has detected its first domestic case of the painful mosquito-borne viral disease chikungunya in the southwest of the country, the state government of Chiapas said on Saturday.
...ITHACA N.Y. Global travel and climate warming could be creating the ...The model predicts that outbreaks of chikungunya a painful virus tran...According to the simulation there is a high probability of a chikungu...Asian tiger mosquitoes were introduced to the United States in Texas i...,Chances,seen,rising,for,chikungunya,outbreaks,in,NYC,,Atlanta,,Miami,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Chikungunya comes from the Swahili language based on patient symptoms, which means (body position) bend or curve (that which contorts or bends up), referring to the bent posture of patients due to a great joint pain (arthralgia). This joint pain by safety data sheets (MSDS) Office of Laboratory Safety Canada, mainly occurs in the knees, ankles and joints, hands and feet. Apart from dengue fever cases are rampant in some parts of Indonesia, the community is also troubled by cases of Chikungunya. These symptoms include sudden fever that reached 39 degrees C, pain in the joints especially the knee joints, ankles, toes and hands and spine, accompanied by a rash (a collection of red dots) on the skin. There is also a headache, conjunctival injection and a little fotofobia ...
John Bacon USA TODAY July 30, 2014 Chikungunya, a mosquito-borne virus that has swept through the Caribbean in recent months, is making gains in the ...
What is Chikungunya Disease? Chikungunya disease is a viral disease transmitted to human by Aedes aegypti and albopictus mosquitoes, containing Chikungunya virus. Right diagnosis is important for the treatment of chikungunya affected patient. There is no cure for the disease and treatment is purely focused on relieving the symptoms. Most of the signs and symptoms are self-limiting. Diagnosis […]. ...
But, it is extremely painful. Dr. Jennifer Halverson, a Minnesota pediatrician who had been working in Haiti, was unlucky enough to contract Chikungunya in April of this year. "Ive broken a bone. Ive had other medical issues." she said. "I dont think Ive ever been in so much pain.". Fortunately, in the US we are not as susceptible to the epidemic spread that some countries are. In fact, Dr. Schaffner said, "I think its difficult to establish itself in the United States because were more separate from the mosquitoes than in the Caribbean. We live in an air conditioning environment and sit on porches - but they are screened… There might be bursts of transmission, but its not very easy to establish in the United States.". Still, we are advised to go ahead and take normal mosquito precautions like draining bird baths, dumping buckets, and getting rid of any other standing water around your property. Stay healthy!. Image via Wikimedia Commons. ...
A French island in the Caribbean has reported locally acquired cases of chikungunya, raising the prospect of the virus spreading across the Americas
A French island in the Caribbean has reported locally acquired cases of chikungunya, raising the prospect of the virus spreading across the Americas
WEST PALM BEACH - Health officials say that for the first time, an American has been infected with chikungunya by a mosquito here in the United States.
Serious international concern continues to exist around the Zika epidemic. The concern has arisen from two possible complications of Zika infection. Permanent fetal brain injury which results in severe microcephaly in some babies and a number of adults developing the neurological disease - Guillain-Barre syndrome, which causes paralysis. There is increasing evidence to indicate that Zika virus can be passed on by transfusion. Blood Services internationally have therefore taken steps to prevent this occurring.. Zika virus is spread by mosquitoes that have acquired the virus from another person who is infected with the virus. Zika virus is spreading in countries where dengue, chikungunya and other mosquito-borne infections are known to occur. Zika infection has many features similar to dengue and chikungunya infections. New Zealand Blood Service (NZBS) introduced measures in November 2014 to protect the blood supply from the risk of transmission of dengue and chikungunya infections. The measures ...
The sign symptoms of Chikungunya disease are almost the same as Dengues thats why misdiagnosis of this disease frequently happens.
Kaur, N., Jain, J., Kumar, A., Narang, M., Zakaria, M.K., Marcello, A., Kumar, D., Gaind, R., Sunil, S. 2017. Chikungunya outbreak in Delhi, India, 2016: A Report on the co-infection status and co-morbid conditions in patients.. New Microbes New Inf. 2017. https://doi.org/10.1016/j.nmni.2017.07.007. Jain, J., Nayak, K., Tanwar, N., Gaind, R., Gupta, B., Shastri, J.S., Bhatnagar, R.K., Murali Krishna Kaja, M.K., Chandele, A., Sunil, S.2017. Clinical, Serological and Virological analysis of 572 chikungunya patients during the years 2010-2013 from India. Clin Infect Dis. doi: 10.1093/cid/cix283. Jain, J., Dubey, S.K., Jatin Shrinet, J., Sunil, S. 2017. Dengue Chikungunya co-infection: A live-in relationship?? Biochem Biophy Res Comm doi: 10.1016/j.bbrc.2017.02.008. Shrinet, J., Srivastava,, P., Sunil, S. 2017. Transcriptome analysis of Aedes aegypti in response to mono-infections and co-infections of Dengue virus-2 and Chikungunya virus. Biochem Biophys Res Commun. doi: ...
CHIKV : Aiding in the diagnosis of recent infection with Chikungunya virus in patients with recent travel to endemic areas and a compatible clinical syndrome
Combating A Mosquito-Borne Disease. Last week, the World Health Organization reported confirmation of the spread of Chikungunya Virus in the southeastern part of the nation. Physicians verified four cases of the tropical disease in the Provence-Alpes-Cote dAzur region. Authorities also revealed the presence of a number of suspected cases of the illness. The patients ranged in age from 3 to 77. They apparently contracted the illness in France after sustaining bites from Aedes albopictus mosquitoes, a species sometimes referred to as the "tiger mosquito" because of its striped body. All of the people who contracted the febrile disease lived in the same region of France. Some people who contract Chikungunya Virus never display overt symptoms of the disease, a factor which may contribute to the spread of virus. Most patients do develop some signs of illness, which may include high fevers and joint pain, skin rashes and headaches.. A Growing Lyme Disease Threat in France. Earlier this summer, health ...
7 free chikungunya vector dengue fever download. All of these Chikungunya vector dengue fever user contributed arts inspire you more creative ideas when you plan to make collages, posters, photo cards, social media arts!
Read more about Sixty chikungunya cases in Delhi on Business Standard. At least 60 cases of chikungunya have been reported in the national capital this year with nearly half of them registered this month, even as the season of the vector-borne diseases ended in December. 16 cases of dengue have also been reported in
Invasion of the CNS is a key event during many viral infections and often a matter of life or death for the host. It is, however, difficult to follow this phenomenon in mammals, hindering the design of preventive strategies.. In the present work, we used zebrafish to characterize the infection course of SINV, a well-established model for the study of viral encephalitis. We focused on its neuroinvasion and compared it with that of CHIKV. This was studied following IV injections, which mimic the natural entry route of these mosquito-transmitted viruses, even though it results in more inter-individual variability than direct IC inoculation. We found that, upon IV inoculation of SINV, infected cells appeared in the periphery as early as 8 hpi, always before infected neurons of the CNS. Infection spontaneously declined in the periphery, probably as a result of the host response. Indeed, qRT-PCR analysis of whole larvae revealed strong induction of type I interferon (IFN) and IFN-stimulated genes of ...
The first animal model of the chikungunya virus (CHIKV), linked with large-scale epidemics that spread to Italy and India in 2007 has been developed by Researchers.
Dr. David Sanders, an expert on mosquito-borne diseases, explains the chikungunya virus and his recommendations to prevent infection while still enjoy
<p>A mutation in the chikungunya virus could lead to more persistant outbreaks that affect larger numbers of people</p>
A team of French and Brazilian researchers warn that chikungunya virus is poised to invade, and become epidemic in the Americas according to research published ahead of print in the Journal of Virology.
Main Article. The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.. ...
This is the first monoclonal antibody encoded by mRNA to be dosed in a human and the first development candidate from the Companys systemic therapeutics modalities to start clinical testing.. We believe this trial will give us important information about how mRNA may be used to make systemically-available complex therapeutic proteins in a consistent, dose-dependent fashion," said Tal Zaks, M.D., Ph.D., chief medical officer at Moderna. "Dosing the first monoclonal antibody encoded by mRNA in humans is a significant milestone for our team and mRNA platform. We look forward to learning about the functionality of our mRNA-encoded antibody in neutralizing the Chikungunya virus.". mRNA-1944 encodes a fully human IgG antibody originally isolated from B cells of a patient with a prior history of potent immunity against Chikungunya infection. It is composed of two mRNAs that encode the heavy and light chains of this anti-Chikungunya antibody within Modernas proprietary lipid nanoparticle (LNP) ...
A mosquito-borne virus that has sickened tens of thousands of people throughout the Carribbean is now threatening the U.S., with cases confirmed in 15 states, the Centers for Disease Control and Prevention Reports.
Scientists say a new test could provide quicker and cheaper diagnosis of&nbsp;a mosquito-bourne virus common in Africa and Asia.
The City of Corpus Christi adopted a tax rate that will raise more taxes for maintenance and operations than last years tax rate. The tax rate will effectively be raised by 4.69 percent and will raise taxes for maintenance and operations on a $100,000 home by approximately $16.87.. ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Comments will be moderated. Remarks containing abusive and obscene language, personal attacks of any kind or promotion will be removed and the user banned.. ...
This issue reviews diagnosis and management of patients with suspected Middle East respiratory syndrome, chikungunya virus infection, and Zika virus infection.
Chikungunya (CHIK-un-goon-ya) virus (also known as CHIKV) is a mosquito-transmitted alphavirus that has spread around the world and is currently infecting people in about 60 countries globally. CHIKV is rarely fatal, but causes severe joint pain for months to years that can debilitate affected patients for long periods of time. There are currently no known drugs to treat CHIKV infection, primarily due to a lack of understanding of the structure of CHIKV proteins involved in viral genome replication. The Geiss lab has worked on developing drug targeting the membrane bound CHIKV nsP1 protein, which is the anchor for the viral genome replication complex on cellular membranes and a multifunctional enzyme that forms a 5 RNA cap structure on the end of the CHIKV RNA genome. Solving the structure of the CHIKV nsP1 protein would provide critical information for designing drugs that inhibit nsP1 function and abort viral genome replication ...
To characterize the immunity developed by patients infected by chikungunya virus (CHIKV), we studied the intensity and specificity of CHIKV-specific T cells mediated responses in chronic and recovered patients at 12 to 24 months post-infection. T cells were challenged in vitro against CHIKV synthetic peptides covering the length of three viral proteins, capsid, E2 and nsP1 proteins as well as all inactivated virus particles. Cytokine production was assessed by ELISPOT and intracellular labeling. T cells producing IFN-γ were detected against CHIKV in 85% patients cells either by direct ELISPOT assay (69% of patients) or after expansion of memory T cells allowing the detection of both CD4 and CD8 specific-T cells in 16% additional cases. The IFN-γ response was mainly engaged in response to nsP1 or E2 (52% and 46% cases, respectively) but in only 27% cases against the capsid. The anti-E2 response represented half the magnitude of the total CHIKV IFN-γ production and was mainly directed against the C
CHIKUNGUNYA Chikungunya, a viral disease with severe illness that is transmitted through the mosquito bites. There is no possibility to have the chikungunya through the direct contact from another person who is already affected through the chikungunya. The condition is not a fatal one but mosquito control is the best method of prevention of chikungunya.…
Many cases have occurred in the United States in people who acquired the virus while traveling, but the first locally transmitted case in the U.S. occurred in Florida in July.. The study showed that the rate of brain infection, or encephalitis, from the chikungunya virus is higher than the rate seen in the United States due to West Nile virus and similar infections between 1999 and 2007. Outbreaks of chikungunya have occurred in numerous areas, including Africa, Asia, the Caribbean islands, and as of September 2015 more than 7,000 cases have been reported in Mexico, according to the Centers for Disease Control and Prevention.. The most common symptoms of the infection are fever and joint pain. Most people recover within a week. For some people, the joint pain can continue for months and even years. "Since there is no vaccine to prevent chikungunya and no medicine to treat it, people who are traveling to these areas should be aware of this infection and take steps to avoid mosquito bites, such as ...
Chikungunya (pronunciation: chik-en-gun-ye), a virus with a difficult name to pronounce, is also proving difficult to contain. Like the more commonly known dengue virus, chikungunya (CHIKV) is an arbovirus, where "arbo" stands for "ARthropod-BOrne." Arthropod vectors most commonly include ticks and mosquitoes. The prevalence of mosquito hosts around the world, as well as travelers infected with exotic arboviruses, make tackling the spread of CHIKV tricky.. CHIKV spreads through two species of mosquito, Aedes albopictus and Aedes aegypti, which bite mostly during the daytime. Both are found in the southeastern and some parts of the southwestern United States. Aedes albopictus is also found in the Mid-Atlantic and lower Midwest. Animal reservoirs, which harbor CHIKV without developing the disease, include monkeys, birds, cattle, and rodents.. The most common symptoms of CHIKV virus infection are fever and joint pain, which appear 4 - 7 days post-infection. Other symptoms may include headache, ...
Sumber : Jakarta Post Wednesday, July 25, 2007 JAMBI, Jambi: Twenty-four Mendalolaut villagers tested positive for chikungunya disease at the Muarojambi Health Office in Jami on Tuesday. Out of the 24 villagers, 15 are already paralyzed by the disease. This is the second outbreak of the disease in the area in the past six months,…
Phase 1 unblinded results up to month 7 showed an excellent immunogenicity and safety profile confirming Valneva´s unique, single-shot vaccine candidate.
A new study in PLoS Neglected Tropical Diseases shows that the Aedes aegypti mosquito can transmit both Zika and chikungunya virus in one bite, and co-infection with the viruses does not alter vector competence.. Dutch scientists infected the insects with both viruses to determine transmission rates using an experimental blood meal and found that 73% of the mosquitoes transmitted Zika, 21% spread chikungunya, and 12% transmitted both viruses in one bite. This is the first study to show that, just as in humans, the viruses can commonly co-infect mosquitoes.. "We show that ZIKV and CHIKV can simultaneously disseminate to the saliva of Ae. aegypti mosquitoes, indicating that co-infections do not strongly interfere with virus replication," the authors write.. In other Zika news, a vaccine presented at the American Society of Microbiology (ASM) Microbe 2017 meeting that wrapped up today showed 100% protection from the virus in mouse models. The vaccine is the first to be based on the NS1 protein, and ...
The understanding of the current chikungunya burden depends on a better understanding of the mortality associated with this arboviruses. Our findings show excess mortality during chikungunya epidemics in three most affected states in Brazil. The correlation between the incidence of chikungunya and increase in all-cause mortality reinforce the possibility that chikungunya virus has an impact on mortality rates. Similar results have already been found in other chikungunya epidemics in the past decades2,3,4. Incidence of dengue virus was high in all studied areas in the years 2011-2013, used as a baseline5. Therefore, we suggest that the excess deaths should be related to chikungunya infections and not another arbovirus that occurs at the same season. This is the first time that the excess mortality associated with chikungunya by age group has been calculated, and the results are very close to that found in the Reunion Islands epidemic using the data obtained in the death certificates16.. Since the ...
Houston and Harris County for instance, are home to two major mosquito species - Aedes aegypti and Aedes albopictus - that can transmit several arboviruses such as dengue, yellow fever, and chikungunya virus. Research led by Dr. Kristy O. Murray provided strong evidence that dengue emerged in Houston between 2003 and 2005. Our region is also home to the Culex mosquitoes that transmit West Nile virus infection. These arbovirus infections have important health and economic consequences for the region. Houston and Harris County for instance, are home to two major mosquito species - Aedes aegypti andAedes albopictus - that can transmit several arboviruses such as dengue, yellow fever, and chikungunya virus. Research led by Dr. Kristy O. Murray provided strong evidence that dengue emerged in Houston between 2003 and 2005. Our region is also home to the Culex mosquitoes that transmit West Nile virus infection. These arbovirus infections have important health and economic consequences for the ...
The mobile country code resource guide gives you the Reunion Island mobile code and shows you how to call a Reunion Island cell phone from Egypt.
Arbovirus Summary Archives. (2008). Repellents, Traps, Virus Information, Maps, etc. Pest Alert. http://entomology.ifas.ufl.edu/pestalert/arbovirus/arbovirus.htm (14 May 2008). Barrera R. 1996. Competition and resistance to starvation in larvae of container-inhabiting Aedes mosquitoes. Ecological Entomology. 21: 117-127. Carpenter SJ, LaCasse WJ. 1955. Mosquitoes of North America (North of Mexico). University of California Press, Berkeley, CA. 360 pp. Centers for Disease Control. (2007). Chikungunya fever fact sheet. Division for Vector-borne Infectious Diseases: Centers for Disease Control. http://www.cdc.gov/ncidod/dvbid/chikungunya/ (13 May 2008). Centers for Disease Control. (2016). Surveillance and Control of Aedes aegypti and Aedes albopictus in the United States. Division of Vector-Borne Diseases: Centers for Disease Control. http://www.cdc.gov/chikungunya/resources/vector-control.html (4/8/2016).. Clements AN. 1999. The Biology of Mosquitoes, Vol. II. Egg laying. Cabi, Wallingford. ...
To the Editor: Zika virus (ZIKV) is a mosquito-borne flavivirus related to yellow fever virus, dengue virus (DENV), and West Nile virus (WNV). It is a single-stranded positive RNA virus (10,794-nt genome) that is closely related to the Spondweni virus and is transmitted by many Aedes spp. mosquitoes, including Ae. africanus, Ae. luteocephalus, Ae. hensilli, and Ae. aegypti. The virus was identified in rhesus monkeys during sylvatic yellow fever surveillance in the Zika Forest in Uganda in 1947 and was reported in humans in 1952 (1).. In 2007, an outbreak of ZIKV was reported in Yap Island, Federated States of Micronesia (2). ZIKV also caused a major epidemic in the French Polynesia in 2013-2014 (3), and New Caledonia reported imported cases from French Polynesia in 2013 and reported an outbreak in 2014 (4).. A new challenge has arisen in Brazil with the emergence of ZIKV and co-circulation with others arboviruses (i.e., DENV and chikungunya virus [CHIKV]). We report ZIKV infection in Brazil ...
Learn how to call Reunion Island from American Samoa. Out complete resource guide gives you the Reunion Island country code & American Samoan dialing code to make your international calls.
Arthropod-borne viruses (arboviruses) can persistently infect and cause limited damage to mosquito vectors. RNA interference (RNAi) is a mosquito antiviral response important in restricting RNA virus replication and has been shown to be active against some arboviruses. The goal of this study was to use a recombinant Sindbis virus (SINV; family Togaviridae; genus Alphavirus) that expresses B2 protein of Flock House virus (FHV; family Nodaviridae; genus Alphanodavirus), a protein that inhibits RNAi, to determine the effects of linking arbovirus infection with RNAi inhibition. B2 protein expression from SINV (TE/32J) inhibited the accumulation of non-specific small RNAs in Aedes aegypti mosquito cell culture and virus-specific small RNAs both in infected cell culture and Ae. aegypti mosquitoes. More viral genomic and subgenomic RNA accumulated in cells and mosquitoes infected with TE/32J virus expressing B2 (TE/32J/B2) compared to TE/32J and TE/32J virus expressing GFP. TE/32J/B2 exhibited increased
Salmonella contamination of 71 chicken broiler flocks was investigated at the slaughterhouse in Reunion Island between October 2007 and January 2009. Samples were collected from live broiler chickens and chicken carcasses as well as the slaughterhouse environment. Salmonella spp. was isolated from 40 of 71 (56 % with a confidence interval 5 % [45-67]) broiler chicken flocks at slaughter. The most prominent serovars were Blockley (31 %), Typhimurium and Brancaster (14 %), Hadar (10 %), Salmonella multidrug resistant clinical organisms serotypes 1,4,[5],12:i:-, and Virchow (8 %) and Livingstone, St. Paul, Seftenberg, Llandoff, Infantis and Indiana. At the farm, 27 % of the broiler chicken flocks tested positive for Salmonella spp. Salmonella spp. was isolated from 124 of 497 environmental samples (25 %). In most cases, there was no relationship between pulsed field gel electrophoresis (PFGE) pattern and antibiotic resistance pattern. The predominant Salmonella serovars were susceptible to most of the
The Cuyahoga County Board of Health continues to work closely with the Ohio Department of Health and conducts surveillance to monitor for mosquitoes that may transmit disease, including the Zika virus. Although local transmission of Zika virus through the bite of a mosquito has not been identified in the continental United States, the U.S. mainland does have two species of mosquitoes that can become infected with and spread Zika virus. The primary vector for transmitting Zika, the Aedes aegypti mosquito, is not established in Ohio and is found in the Southeastern States. A possible second vector, the Aedes albopictus mosquito, is also known as the Asian Tiger mosquito and is rarely found in Northeast Ohio. These species of mosquitoes do not breed in storm water control basins or woodland pools. They prefer to breed in water that collects in artificial containers (tires, buckets, garbage cans, flower pots, childrens toys, etc.). Residents can help reduce the local mosquito population by removing ...

Ross River virus infectionRoss River virus infection

Ross River virus (RRV) is a group A arbovirus transmitted by mosquitoes that causes a disease manifested by polyarthritis and ... Chikungunya fever. *Prevention of arthropod and insect bites: Repellents and other measures ... Barmah Forest virus epidemic on the south coast of New South Wales, Australia, 1994-1995: viruses, vectors, human cases, and ... Other viruses that cause arthritis are discussed separately. (See Specific viruses that cause arthritis.) ...
more infohttps://www.uptodate.com/contents/ross-river-virus-infection

Blog #24 Ross River Virus Disease - ATHNABlog #24 Ross River Virus Disease - ATHNA

Pacific islands may be at risk but most clinicians in the US have never seen a case and dont know much about Ross River Virus ... Ross River Virus has been in the news lately because of recent outbreaks in Australia where it is endemic. Travelers to ... Methotrexate, useful in chikungunya, has not been shown to be effective in RRVD. Monocytes appear to play a more important role ... Ross River Virus is a mosquito-borne alpha virus of the Togaviridae family. It was first isolated in 1963 near the Ross River ...
more infohttps://athnablog.wordpress.com/2018/01/15/blog-24-ross-river-virus-disease/

Chikungunya virus | CDCChikungunya virus | CDC

Information on Chikungunya virus. Provided by the U.S. Centers for Disease Control and Prevention. ... chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will ... Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and ... When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with ...
more infohttp://www.cdc.gov/chikungunya/

Chikungunya virus | CDCChikungunya virus | CDC

Information on Chikungunya virus. Provided by the U.S. Centers for Disease Control and Prevention. ... chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will ... Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and ... When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with ...
more infohttps://www.cdc.gov/chikungunya

Chikungunya Virus | SpringerLinkChikungunya Virus | SpringerLink

The mosquito-transmitted Chikungunya virus (CHIKV) is associated with increased morbidity and debilitating chronic ... Chikungunya Virus: Advances in Biology, Pathogenesis, and Treatment details the exciting discoveries that have been made in ... Vaccines Against Chikungunya Virus Infection Karl Ljungberg, Beate M. Kümmerer, Pierre Roques, Mariano Esteban, Andres Merits, ... The mosquito-transmitted Chikungunya virus (CHIKV) is associated with increased morbidity and debilitating chronic ...
more infohttps://link.springer.com/book/10.1007%2F978-3-319-42958-8

Chikungunya virus: MedlinePlus Medical EncyclopediaChikungunya virus: MedlinePlus Medical Encyclopedia

The name chikungunya (pronounced chik-en-gun-ye) is an African word meaning bent ... Chikungunya is a virus passed to humans by the bite of infected mosquitoes. Symptoms include fever and severe joint pain. ... How Chikungunya Can Spread. Mosquitoes spread the virus to humans. Mosquitoes pick up the virus when they feed on infected ... Chikungunya virus. www.cdc.gov/chikungunya. Updated December 17, 2018. Accessed May 29, 2019. ...
more infohttps://medlineplus.gov/ency/patientinstructions/000821.htm

Chikungunya Virus Disease | Summary | NNDSSChikungunya Virus Disease | Summary | NNDSS

Chikungunya virus disease 2005. Current. Eastern equine encephalitis virus disease(https://wwwn.cdc.gov/nndss/conditions/ ... wwwn.cdc.gov/nndss/conditions/chikungunya-virus-disease/case-definition/2015/) * Arboviral Diseases, Neuroinvasive and Non- ... wwwn.cdc.gov/nndss/conditions/chikungunya-virus-disease/case-definition/2011/) * Arboviral Diseases, Neuroinvasive and Non- ... wwwn.cdc.gov/nndss/conditions/chikungunya-virus-disease/case-definition/2014/) ...
more infohttps://wwwn.cdc.gov/nndss/conditions/chikungunya-virus-disease/

Chikungunya Virus Infection Symptoms & TreatmentChikungunya Virus Infection Symptoms & Treatment

Read information written by doctors about Chikungunya virus infection transmission (how you get it), common symptoms are fever ... What are Chikungunya virus infection symptoms and signs?. *How do health care professionals diagnose Chikungunya virus ... What are Chikungunya virus infection symptoms and signs?. *How do health care professionals diagnose Chikungunya virus ... home/infectious disease health center/infectious disease a-z list/chikungunya virus infection center /chikungunya virus ...
more infohttps://www.medicinenet.com/chikungunya_virus_infection/article.htm

Chikungunya virus | MSDSonlineChikungunya virus | MSDSonline

PATHOGENICITY/TOXICITY: Translated from the African dialect of Swahili or Makonde, chikungunya means, "that which bends up" (1 ... SUSCEPTIBILITY TO DISINFECTANTS: No information specific to CHIKV; however, most lipid enveloped viruses are sensitive to 70% ( ... SYNONYM OR CROSS REFERENCE: CHIKV (1-6), CHIK (2, 7-9), and chikungunya fever (2, 10). ... the virus was isolated repeatedly from numerous countries in Central and Southern Africa, including Sudan, Uganda, Democratic ...
more infohttps://www.msdsonline.com/resources/msds-resources/free-safety-data-sheet-index/chikungunya-virus/

Chikungunya virus | MSDSonlineChikungunya virus | MSDSonline

PATHOGENICITY/TOXICITY: Translated from the African dialect of Swahili or Makonde, chikungunya means, "that which bends up" (1 ... SUSCEPTIBILITY TO DISINFECTANTS: No information specific to CHIKV; however, most lipid enveloped viruses are sensitive to 70% ( ... SYNONYM OR CROSS REFERENCE: CHIKV (1-6), CHIK (2, 7-9), and chikungunya fever (2, 10). ... the virus was isolated repeatedly from numerous countries in Central and Southern Africa, including Sudan, Uganda, Democratic ...
more infohttps://www.msdsonline.com/resources/sds-resources/free-safety-data-sheet-index/chikungunya-virus/

Chikungunya virus, southeastern France.  - PubMed - NCBIChikungunya virus, southeastern France. - PubMed - NCBI

Phylogenetic relationships among chikungunya virus isolates from cases of chikungunya fever in France, based on complete E2-6K- ... Chikungunya virus, southeastern France.. Grandadam M1, Caro V, Plumet S, Thiberge JM, Souarès Y, Failloux AB, Tolou HJ, Budelot ... In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes ... viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/21529410?dopt=Abstract

Chikungunya Virus Has Spread To USChikungunya Virus Has Spread To US

Chikungunya virus has made its appearance well known in the United States this year. In fact, cases have gone from a normal 28 ... The virus was first recorded in 1952 in Africa then Asia, but in 2013 it began to spread to the Caribbean and Haiti. Travelers ... The virus is transmitted by mosquito, but not human to human. Fortunately, it isnt fatal, but it is extremely painful. ... Chikungunya causes a rash, fever, and excruciating joint pain that last from five to seven days. However, Dr. William Schaffner ...
more infohttps://www.webpronews.com/chikungunya-virus-has-spread-to-us/

BioCollections Worldwide Chikungunya Virus Assay | GenomeWebBioCollections Worldwide Chikungunya Virus Assay | GenomeWeb

... assay follows the US Centers for Disease Control and Preventions real-time RT-PCR protocol for detection of Chikungunya virus ... BioCollections Worldwide said today that it is now offering a laboratory-developed test for the detection of Chikungunya virus ... BioCollections Worldwide said today that it is now offering a laboratory-developed test for the detection of Chikungunya virus ... assay follows the US Centers for Disease Control and Preventions real-time RT-PCR protocol for detection of Chikungunya virus ...
more infohttps://www.genomeweb.com/resources/new-product/biocollections-worldwide-chikungunya-virus-assay

Chikungunya Virus Arrives In Americas - Business InsiderChikungunya Virus Arrives In Americas - Business Insider

... the chikungunya virus had infected at least 200 people. But in the last week alone, it infected more than twice that number. ... Other famous examples include the West Nile virus and dengue fever. Both dengue and the chikungunya virus are spread by the ... From early December to mid-January, the chikungunya virus had infected at least 200 people, epidemiologists say. But in the ... The virus is not usually fatal, though, with 1 death in every 1,000 cases, and then usually only in the elderly or immune- ...
more infohttps://www.businessinsider.com/chikungunya-virus-arrives-in-americas-2014-1

CHIKUNGUNYA VIRUS ANTIBODYCHIKUNGUNYA VIRUS ANTIBODY

Chikungunya IgM, Chikungunya IgM antibody, Anti-chikungunya IgG, Anti-chikungunya IgG antibody, Chikungunya IgG, Chikungunya ... Anti-chikungunya IgM, Anti-chikungunya IgM antibody, ...
more infohttps://www.sgh.com.sg/patient-care/specialties-services/chikungunya-virus-antibody

Chikungunya virus infection: an overview.  - PubMed - NCBIChikungunya virus infection: an overview. - PubMed - NCBI

Chikungunya virus infection: an overview.. Caglioti C1, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L. ... Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus belonging to the Togaviridae family, first isolated in Tanzania ... Diagnosis is based on the detection of virus by molecular methods or by virus culture on the first days of infection, and by ... Differential diagnosis should take into account the cross-reactivity with other viruses from the same antigenic complex (i.e. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23912863?dopt=Abstract

Dropbox - 2017 Epidemiology of Chikungunya Virus .pdfDropbox - 2017 Epidemiology of Chikungunya Virus .pdf

Dropbox is a free service that lets you bring your photos, docs, and videos anywhere and share them easily. Never email yourself a file again!
more infohttps://www.dropbox.com/s/xdzad3ibsabs8w0/2017%20Epidemiology%20of%20Chikungunya%20Virus%20.pdf?dl=0

Chikungunya VirusChikungunya Virus

... Chikungunya (pronunciation: chik-en-gun-ye) virus is transmitted to people by mosquitoes. The most common ... There is no vaccine to prevent or medicine to treat Chikungunya virus. If you believe you have Chikungunya, prevent mosquito ... Chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will ... During the first week of infection, Chikungunya virus can be found in the blood and passed from an infected person to a ...
more infohttps://www.cor.net/departments/health-department/environmental-health/insect-and-vector-management/mosquito-control/chikungunya-virus

Chikungunya Virus | J. Craig Venter InstituteChikungunya Virus | J. Craig Venter Institute

Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus. ... Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic. ... Chikungunya (CHIKV) has been the cause of multiple outbreaks and infects greater than one million people every year. CHIKV was ... which increases the need to better understand the sequence diversity of these viruses and how any viral mutations affect the ...
more infohttps://www.jcvi.org/gcid/project/chikungunya-virus

Threatwatch: Chikungunya virus spreads in the Americas | New ScientistThreatwatch: Chikungunya virus spreads in the Americas | New Scientist

... raising the prospect of the virus spreading across the Americas ... Caribbean has reported locally acquired cases of chikungunya, ... Threatwatch: Chikungunya virus spreads in the Americas. Threatwatch is your early warning system for global dangers, from ... A dozen people on the tiny Caribbean island of St Martin have been infected with the chikungunya virus. It is the first time ... But blood samples sent for testing in France confirmed the presence of chikungunya. The virus would have been brought to the ...
more infohttps://www.newscientist.com/article/dn24757-threatwatch-chikungunya-virus-spreads-in-the-americas/?ignored=irrelevant

Threatwatch: Chikungunya virus spreads in the Americas | New ScientistThreatwatch: Chikungunya virus spreads in the Americas | New Scientist

... raising the prospect of the virus spreading across the Americas ... Caribbean has reported locally acquired cases of chikungunya, ... Threatwatch: Chikungunya virus spreads in the Americas. Threatwatch is your early warning system for global dangers, from ... A dozen people on the tiny Caribbean island of St Martin have been infected with the chikungunya virus. It is the first time ... But blood samples sent for testing in France confirmed the presence of chikungunya. The virus would have been brought to the ...
more infohttps://www.newscientist.com/article/dn24757-threatwatch-chikungunya-virus-spreads-in-the-americas/

Chikungunya Virus Confirmed in 15 States: CDCChikungunya Virus Confirmed in 15 States: CDC

A mosquito-borne virus that has sickened tens of thousands of people throughout the Carribbean is now threatening the U.S., ... The chikungunya virus - or chik-v - causes high fever and severe pain, and there is no vaccine to prevent it, CBS News ... this virus, back to the United States, Dr. Schaffner said. We have the kind of mosquito that will transmit this virus here in ... A mosquito-borne virus that has sickened tens of thousands of people throughout the Carribbean is now threatening the U.S., ...
more infohttps://www.newsmax.com/health/health-news/chikungunya-virus-united-states/2014/06/17/id/577638/

Two Contract Mosquito-Borne Chikungunya Virus in Florida - WSJTwo Contract Mosquito-Borne Chikungunya Virus in Florida - WSJ

Public health officials in Florida on Thursday confirmed that two people in the state contracted the mosquito-borne chikungunya ... Two Contract Mosquito-Borne Chikungunya Virus in Florida. Puerto Rico Declares Chikungunya Epidemic With Over 100 Confirmed ... The virus, which is transmitted from mosquitoes to humans and vice versa, has been spreading rapidly through the Caribbean ... health officials in Florida said Thursday that two people in the state contracted the mosquito-borne chikungunya virus locally ...
more infohttps://www.wsj.com/articles/mosquito-borne-virus-epidemic-declared-in-puerto-rico-1405624993?mod=googlewsj

Guillain-Barre syndrome complicating chikungunya virus infection | SpringerLinkGuillain-Barre syndrome complicating chikungunya virus infection | SpringerLink

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and ... Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and ... Guillain-Barre syndrome Chikungunya virus Plasmapharesis Mosquito-borne diseases This is a preview of subscription content, log ... Chandak NH, Kashyap RS, Kabra D et al (2009) Neurological complications of chikungunya virus infection. Neurol India 57:177-180 ...
more infohttps://link.springer.com/article/10.1007%2Fs13365-017-0516-1
  • Lau C, Aubry M, Musso D, Teissier A, Paulous S, Desprès P, de-Lamballerie X, Pastorino B, Cao-Lormeau VM, Weinstein P. New evidence for endemic circulation of Ross River virus in the Pacific Islands and the potential for emergence. (wordpress.com)
  • Travelers to Australia, Papua New Guinea, and multiple other Pacific islands may be at risk but most clinicians in the US have never seen a case and don't know much about Ross River Virus Disease. (wordpress.com)
  • 2018. Ross River virus disease , accessed Jan 12, 2018. (wordpress.com)
  • Liu X, Tharmarajah K, Taylor A. Ross River virus disease clinical presentation, pathogenesis and current therapeutic strategies. (wordpress.com)
  • The range is spreading and there's evidence that climate change is altering the transmission of this virus. (wordpress.com)
more