A species of ALPHAVIRUS causing an acute dengue-like fever.
Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.
One of the Indian Ocean Islands, east of Madagascar. Its capital is Saint-Denis. It was discovered in 1507 by the Portuguese and claimed by France in 1638. It was first colonized in 1662 as Isle de Bourbon but renamed Reunion in 1793. In 1946 it was made an overseas department of France. The name commemorates the reunion of the revolutionaries from Marseilles with the National Guard in Paris in 1792. (From Webster's New Geographical Dictionary, 1988, p1011; Room, Brewer's Dictionary of Names, 1992, p454; French Embassy)
A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.
Numerous islands in the Indian Ocean situated east of Madagascar, north to the Arabian Sea and east to Sri Lanka. Included are COMOROS (republic), MADAGASCAR (republic), Maldives (republic), MAURITIUS (parliamentary democracy), Pemba (administered by Tanzania), REUNION (a department of France), and SEYCHELLES (republic).
A group of Indian Ocean Islands, the islands of Great Comoro, Anjouan, Mayotte, and Moheli, lying between northeast Mozambique and northwest Madagascar. The capital is Moroni. In 1914 they became a colony attached to Madagascar administratively and were made a French overseas territory in 1947. Except for Mayotte which remained French, Comoros became an independent republic in 1975. Comoros represents the Arabic qamar, moon, said by some scholars to be linked with the mystical Mountains of the Moon said to be somewhere in equatorial Africa. (From Webster's New Geographical Dictionary, 1988, p283 & Room, Brewer's Dictionary of Names, 1992, p122)
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
A genus of TOGAVIRIDAE, also known as Group A arboviruses, serologically related to each other but not to other Togaviridae. The viruses are transmitted by mosquitoes. The type species is the SINDBIS VIRUS.
Infections caused by arthropod-borne viruses, general or unspecified.
A body of water covering approximately one-fifth of the total ocean area of the earth, extending amidst Africa in the west, Australia in the east, Asia in the north, and Antarctica in the south. Including the Red Sea and the Persian Gulf, it constitutes the third largest ocean after the ATLANTIC OCEAN and the PACIFIC OCEAN. (New Encyclopaedia Britannica Micropaedia, 15th ed, 1990, p289)
A species of ALPHAVIRUS associated with epidemic EXANTHEMA and polyarthritis in Australia.
A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.
The geographical area of Africa comprising CAMEROON; CENTRAL AFRICAN REPUBLIC; CHAD; CONGO; EQUATORIAL GUINEA; GABON; and DEMOCRATIC REPUBLIC OF THE CONGO.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
The geographical area of Africa comprising BURUNDI; DJIBOUTI; ETHIOPIA; KENYA; RWANDA; SOMALIA; SUDAN; TANZANIA; and UGANDA.
Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Aspects of health and disease related to travel.
Pain in the joint.
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.
Ribonucleic acid that makes up the genetic material of viruses.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
The relationships of groups of organisms as reflected by their genetic makeup.
Viruses whose genetic material is RNA.
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
A republic in southern Africa, southwest of DEMOCRATIC REPUBLIC OF THE CONGO and west of ZAMBIA. Its capital is Luanda.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
A republic in west equatorial Africa, south of CAMEROON and west of the CONGO. Its capital is Libreville.
Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.
Process of growing viruses in live animals, plants, or cultured cells.
The presence of viruses in the blood.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.
The maintenance of certain aspects of the environment within a defined space to facilitate the function of that space; aspects controlled include air temperature and motion, radiant heat level, moisture, and concentration of pollutants such as dust, microorganisms, and gases. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Sudden outbreaks of a disease in a country or region not previously recognized in that area, or a rapid increase in the number of new cases of a previous existing endemic disease. Epidemics can also refer to outbreaks of disease in animal or plant populations.
Method of making images on a sensitized surface by exposure to light or other radiant energy.

Vectors of Chikungunya virus in Senegal: current data and transmission cycles. (1/380)

Chikungunya fever is a viral disease transmitted to human beings by Aedes genus mosquitoes. From 1972 to 1986 in Kedougou, Senegal, 178 Chikungunya virus strains were isolated from gallery forest mosquitoes, with most of them isolated from Ae. furcifer-taylori (129 strains), Ae. luteocephalus (27 strains), and Ae. dalzieli (12 strains). The characteristics of the sylvatic transmission cycle are a circulation periodicity with silent intervals that last approximately three years. Few epidemics of this disease have been reported in Senegal. The most recent one occurred in 1996 in Kaffrine where two Chikungunya virus strains were isolated from Ae. aegypti. The retrospective analysis of viral isolates from mosquitoes, wild vertebrates, and humans allowed to us to characterize Chikungunya virus transmission cycles in Senegal and to compare them with those of yellow fever virus.  (+info)

Comparison of PanBio dengue duo enzyme-linked immunosorbent assay (ELISA) and MRL dengue fever virus immunoglobulin M capture ELISA for diagnosis of dengue virus infections in Southeast Asia. (2/380)

The performances of the MRL dengue fever virus immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) and the PanBio Dengue Duo IgM capture and IgG capture ELISA were compared. Eighty sera from patients with dengue virus infections, 24 sera from patients with Japanese encephalitis (JE), and 78 sera from patients with nonflavivirus infections, such as malaria, typhoid, leptospirosis, and scrub typhus, were used. The MRL test showed superior sensitivity for dengue virus infections (94 versus 89%), while the PanBio test showed superior specificity for JE (79 versus 25%) and other infections (100 versus 91%). The PanBio ELISA showed better overall performance, as assessed by the sum of sensitivity and specificity (F value). When dengue virus and nonflavivirus infections were compared, F values of 189 and 185 were obtained for the PanBio and MRL tests, respectively, while when dengue virus infections and JE were compared, F values of 168 and 119 were obtained. The results obtained with individual sera in the PanBio and MRL IgM ELISAs showed good correlation, but this analysis revealed that the cutoff value of the MRL test was set well below that of the PanBio test. Comparing the sensitivity and specificity of the tests at different cutoff values (receiver-operator analysis) revealed that the MRL and PanBio IgM ELISAs performed similarly in distinguishing dengue virus from nonflavivirus infections, although the PanBio IgM ELISA showed significantly better distinction between dengue virus infections and JE. The implications of these findings for the laboratory diagnosis of dengue are discussed.  (+info)

Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. (3/380)

Chikungunya (CHIK) virus is a member of the genus Alphavirus in the family TOGAVIRIDAE: Serologically, it is most closely related to o'nyong-nyong (ONN) virus and is a member of the Semliki Forest antigenic complex. CHIK virus is believed to be enzootic throughout much of Africa and historical evidence indicates that it spread to other parts of the world from this origin. Strains from Africa and Asia are reported to differ biologically, indicating that distinct lineages may exist. To examine the relatedness of CHIK and ONN viruses using genetic data, we conducted phylogenetic studies on isolates obtained throughout Africa and Southeast Asia. Analyses revealed that ONN virus is indeed distinct from CHIK viruses, and these viruses probably diverged thousands of years ago. Two distinct CHIK virus lineages were delineated, one containing all isolates from western Africa and the second comprising all southern and East African strains, as well as isolates from Asia. Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa and subsequently was introduced into Asia. Within the eastern Africa and southern Africa/Asia lineage, Asian strains grouped together in a genotype distinct from the African groups. These different geographical genotypes exhibit differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquito vectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with AE: furcifer and AE: africanus mosquitoes.  (+info)

Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218. (4/380)

We conducted a phase II, randomized, double-blind, placebo-controlled, safety and immunogenicity study of a serially passaged, plaque-purified live chikungunya (CHIK) vaccine in 73 healthy adult volunteers. Fifty-nine volunteers were immunized one time subcutaneously with the CHIK vaccine and 14 were immunized with placebo (tissue culture fluid). Vaccinees were clinically evaluated intensively for one month, and had repeated blood draws for serological assays (50% plaque-reduction neutralization test) for one year. Except for transient arthralgia in five CHIK vaccinees, the number and severity of local and systemic reactions and abnormal laboratory tests after immunization were similar in CHIK vaccinees and placebo recipients. Fifty-seven (98%) of 58 evaluable CHIK vaccinees developed CHIK neutralizing antibody by day 28, and 85% of vaccinees remained seropositive at one year after immunization. No placebo recipients seroconverted. This promising live vaccine was safe, produced well-tolerated side effects, and was highly immunogenic.  (+info)

Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site. (5/380)

In this study, the complete genomic sequence of chikungunya virus (CHIK; S27 African prototype) was determined and the presence of an internal polyadenylation [I-poly(A)] site was confirmed within the 3' non-translated region (NTR) of this strain. The complete genome was 11805 nucleotides in length, excluding the 5' cap nucleotide, an I-poly(A) tract and the 3' poly(A) tail. It comprised two long open reading frames that encoded the non-structural (2474 amino acids) and structural polyproteins (1244 amino acids). The genetic location of the non-structural and structural proteins was predicted by comparing the deduced amino acid sequences with the known cleavage sites of other alphaviruses, located at the C-terminal region of their virus-encoded proteins. In addition, predicted secondary structures were identified within the 5' NTR and repeated sequence elements (RSEs) within the 3' NTR. Amino acid sequence homologies, phylogenetic analysis of non-structural and structural proteins and characteristic RSEs revealed that although CHIK is closely related to o'nyong-nyong virus, it is in fact a distinct virus. The existence of I-poly(A) fragments with different lengths (e.g. 19, 36, 43, 91, 94 and 106 adenine nucleotides) at identical initiation positions for each clone strongly suggests that the polymerase of the alphaviruses has a capacity to create poly(A) by a template-dependant mechanism such as 'polymerase slippage', as has been reported for vesicular stomatitis virus.  (+info)

Effect of temperature stress on immature stages and susceptibility of Aedes aegypti mosquitoes to chikungunya virus. (6/380)

A high temperature stress of 44.5 degrees C for 10 minutes on the larval stages was found to affect the susceptibility of adult Aedes aegypti mosquitoes to chikungunya virus. At this temperature, the mortality of the mosquito larvae was found to be approximately 95%, whereas a temperature greater than 45 degrees C for 10 minutes was found to be lethal. A temperature tolerant (TT) strain was developed by exposing the larvae to a temperature of 44.5 degrees C for 10 minutes at every generation for five generations. This strain was established to determine whether increase in the susceptibility was due to any selection pressure of higher temperature or to the influence of other intrinsic factors such as expression of immunoresponsive (IR) genes. Other studies on these mosquito strains showed that when maintained at 28 +/- 1 degrees C, there was no difference in the larval duration and mortality in the immature stages, but the mean survival of female mosquitoes in the TT strain was 5-6 days longer. Conversely, when mosquitoes were maintained throughout at 37 degrees C the mean survival of the mosquitoes decreased drastically in both strains, but the mean survival of females in the TT strain was 5-6 days longer compared with the unstressed controls. This increases the probability of at least one more blood meal. Fecundity of the TT strain was found to be lower than that of the control mosquitoes. Data suggest that expression of certain IR genes was affected by the heat shock. Some of these genes were up-regulated and down-regulated, which may have affected the susceptibility of mosquitoes to the virus. Although there was some selection in the temperature-tolerant individuals in the TT strain, when stressed by heat they showed expression of IR genes in a pattern similar to that in the normal controls. It appears that an increase in temperature above the average temperature of an area might help increase the proportion of virus-susceptible mosquitoes in the population. Such an increase in temperature in an endemic area would not only enhance the selection of temperature-tolerant individuals in a population having more longevity, but would also affect both intrinsic and extrinsic factors by reducing the extrinsic incubation period and increasing susceptibility of mosquitoes to viruses due to affected expression of IR genes.  (+info)

Differential infectivities of o'nyong-nyong and chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes. (7/380)

O'nyong-nyong virus (ONNV) and chikungunya virus (CHIKV) are closely related alphaviruses that cause human disease in Africa and Asia. Like most alphaviruses, CHIKV is vectored by culicine mosquitoes. ONNV is considered unusual as it primarily infects anopheline mosquitoes; however, there are relatively few experimental data to support this. In this study, three strains of ONNV and one strain of CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes and in four cell lines. As predicted, CHIKV was not infectious to An. gambiae, and we observed strain-variability for ONNV with respect to the ability of the virus to infect An. gambiae and Ae. aegypti. The species specificity in vivo was reflected by in vitro experiments using culicine and anopheline-derived cell lines.  (+info)

Determinants of vector specificity of o'nyong nyong and chikungunya viruses in Anopheles and Aedes mosquitoes. (8/380)

The alphaviruses o'nyong nyong virus (ONNV) and chikungunya virus (CHIKV) provide a unique system to study the viral genes involved in vector specificity. ONNV infects both anopheline and culicine mosquitoes, whereas CHIKV infects only culicine mosquitoes. In this study, chimeric viruses were constructed that contained genes from both ONNV and CHIKV. These chimeras and previously described full-length infectious clones of ONNV and CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes. Virus derived from the infectious clones of ONNV and CHIKV retained the vector specificity of the parental viruses. All six of the chimeras were found to infect Ae. aegypti mosquitoes at high rates but only the chimera containing viral genes encoding all of the structural proteins of ONNV was able to infect An. gambiae mosquitoes. These data indicate that all of the viral structural proteins are necessary for ONNV to infect An. gambiae mosquitoes.  (+info)

Chikungunya virus infection in neonates is relatively rare and can lead to death. We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms. The pre-term newborn weighed 2535 g, with an Apgar score of 4/8. He was referred to the neonatal ICU with neutrophilia and thrombocytopenia, several seizure episodes, and hemorrhagic disorders, which resulted in death. Chikungunya IgM antibody was detected in the cerebrospinal fluid. We present the first documented maternal and neonatal death in Brazil after probable chikungunya infection during pregnancy.
TY - JOUR. T1 - Characterization of chikungunya virus induced host response in a mouse model of viral myositis. AU - Dhanwani, Rekha. AU - Khan, Mohsin. AU - Lomash, Vinay. AU - Rao, Putcha Venkata Lakshmana. AU - Ly, Hinh. AU - Parida, Manmohan. PY - 2014/3/25. Y1 - 2014/3/25. N2 - While a number of studies have documented the persistent presence of chikungunya virus (CHIKV) in muscle tissue with primary fibroblast as the preferable cell target, little is known regarding the alterations that take place in muscle tissue in response to CHIKV infection. Hence, in the present study a permissive mouse model of CHIKV infection was established and characterized in order to understand the pathophysiology of the disease. The two dimensional electrophoresis of muscle proteome performed for differential analysis indicated a drastic reprogramming of the proteins from various classes like stress, inflammation, cytoskeletal, energy and lipid metabolism. The roles of the affected proteins were explained in ...
The European Centre for Disease Prevention and Control issued a risk assessment on the ongoing outbreak of chikungunya virus infection in Italy. Two r...
The Mississippi State Department of Health has confirmed a number of cases of chikungunya virus infection in Mississippi residents recently returned from Haiti and the Dominican Republic. Other possible cases are under investigation. Mississippians who travel to the Dominican Republic, Haiti, Puerto Rico or other Caribbean countries are at risk of chikungunya virus. Chikungunya can spread from person to person through the bite of a mosquito once travelers return home. See protective measures for travelers ». ...
Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of viral genome into the host cytoplasm for replication. How the E1 structure determines membrane fusion and whether other CHIKV structural proteins participate in E1 fusion activity remain largely unexplored. A bicistronic baculovirus expression system to produce recombinant baculoviruses for cell-based assay was used. Sf21 insect cells infected by recombinant baculoviruses bearing wild type or single-amino-acid substitution of CHIKV E1 and EGFP (enhanced green fluorescence protein) were employed to investigate the roles of four E1 amino acid residues (G91, V178, A226, and H230) in membrane fusion activity. Western blot analysis revealed that the E1 expression level and surface features in wild type and mutant substituted cells were similar. However, cell fusion assay found that those cells infected by
Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of viral genome into the host cytoplasm for replication. How the E1 structure determines membrane fusion and whether other CHIKV structural proteins participate in E1 fusion activity remain largely unexplored. A bicistronic baculovirus expression system to produce recombinant baculoviruses for cell-based assay was used. Sf21 insect cells infected by recombinant baculoviruses bearing wild type or single-amino-acid substitution of CHIKV E1 and EGFP (enhanced green fluorescence protein) were employed to investigate the roles of four E1 amino acid residues (G91, V178, A226, and H230) in membrane fusion activity. Western blot analysis revealed that the E1 expression level and surface features in wild type and mutant substituted cells were similar. However, cell fusion assay found that those cells infected by
Inthukantham Kashaya and Vilvadi Gulika are the medicines that can be taken as preventive measures of chikungunya .Ayurveda suggests carrot and sunflower seeds as good supplements for chikungunya patients as they strengthen persons resistance to fight disease. Triphala, an ayurvedic composition of Harada, Amla and Behada and dry seedless grapes are also effective in controlling symptoms of chikungunya. Ayurvedic treatment for bringing relief from various symptoms of chikungunya include: Fever in Chikunguya: Sacred Basil (Tulsi) leaves are very effective in reducing chikungunya fever. Vilvadi Gulika, Amritarishta and Sudarsanam Gulika are the other commonly prescribed ayurvedic medicines for fighting the fever. Muscle and Joint Pain in Chikungunya The patients of chikungunya face severe joint and muscle pain. This pain can even persist from months to years. Useful ayurvedic medications for controlling pain in chikungunya include: ...
Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. We herein analysed the innate immune response (cytokine and programmed cell death) of RAW264.7 mouse macrophages following CHIKV infection. We found that the infection was restrained to a small percentage of cells and was not associated with a robust type I IFN innate immune response (IFN-α4 and ISG56). TNF-α, IL-6 and GM-CSF expression were upregulated while IFN-γ, IL-1α, IL-2, IL-4, IL-5, IL-10 or IL-17 expression could not be evidenced prior to and after CHIKV exposure. Although CHIKV is known to drive apoptosis in many cell types, we found no canonical signs of programmed cell death (cleaved caspase-3, -9) in infected RAW264.7 cells. These data argue for the capacity of CHIKV to infect and drive a specific innate immune response in RAW264.7 macrophage cell which seems
Another name for Chikungunya Disease is Chikungunya Disease. What is Chikungunya disease? A person with Chikungunya disease has an infection caused by ...
Author Summary Chikungunya virus (CHIKV) is transmitted by mosquito bites and causes a febrile disease that is often characterized by persistent joint pain. Until recently, CHIKV outbreaks were limited to tropical areas of Africa and Asia. However, since 2007, following a large CHIKV epidemic in the Indian Ocean and South-East Asia, CHIKV has also been reported in temperate European regions. As mosquito habitats expand, virus dissemination may become more prevalent, but there are currently no vaccines or CHIKV-specific treatments available. We previously described two human antibodies that potently block cellular CHIKV infection. In the current report, we have characterized CHIKV mutants that escape neutralization to identify sub-domains of the virus envelope which are involved in CHIKV interaction with these antibodies, thereby opening the door for the development of CHIKV-specific sub-domain vaccination strategies. For the first time, we have also demonstrated that CHIKV can be directly transmitted
In 2005-6, more than 1.5 million people in the Indian Ocean area were infected with Chikungunya fever. In Reunion Island, 38.3% of the population, approximately 300 000 people, were infected.1 Only 6% of the cases were asymptomatic. Chikungunya fever is a viral infection transmitted to humans by Aedes mosquitoes.2,3 Chikungunya infection usually causes a syndrome characterised by fever, headaches, chills, conjunctivitis, rash, myalgia and severe joint pain with or without swelling. Joint symptoms vary from polyarthralgia to symmetrical polyarthritis. The outcome is usually benign, but persistent joint pain and stiffness may occur.3,4,5,6,7,8. We report 21 cases … ...
The Cook Islands Ministry of Health has confirmed seven cases of chikungunya on Rarotonga since November 2014, in which three of the cases were considered locally acquired.. Local transmission means that mosquitoes in the area have been infected with chikungunya and are spreading it to people.. CDC recommends that travelers to the Cook Islands protect themselves from mosquito bites. Some travelers may be more likely to get chikungunya, have severe disease, or be at higher risk for other reasons. CDC advises travelers in high-risk groups to discuss their travel plans with their health care provider.. Chikungunya is a viral disease transmitted by the bite of infected mosquitoes such as Aedes aegypti and Aedes albopictus. It can cause high fever, join and muscle pain, and headache. Chikungunya does not often result in death, but the joint pain may last for months or years and may become a cause of chronic pain and disability.. There is no specific treatment for chikungunya infection, nor any ...
Their newest investigation analyzed recent events in chikungunya virus evolution that will aid in predicting future trends in transmission and circulation that determine epidemic potential. Weaver and his team found that the initial adaption provided the framework for a second wave of adaptations that can enable rapid diversification of viral strains and even more efficient transmission to people. In addition, analysis of the chikungunya virus strain expressing a combination of the second-wave adaptive mutations revealed a similar pattern of changes and heightened adaptive qualities suggesting the future emergence of even higher transmission efficiency. ...
Abstract Five species of mosquito were studied to compare their susceptibility to infection, ability to sustain infection, and vector efficiency over a 4- to 5-week period after being infected with an African strain of chikungunya virus. Aedes triseriatus and Aedes albopictus were readily infected with the virus and maintained the highest infection and transmission rates of the mosquitoes tested during the test period. Aedes togoi also maintained a very high infection rate, but was a poor transmitter. Eretmapodites chrysogaster exhibited fairly high infection rates throughout the test and relatively high transmission rates in the latter half of the 35-day test period. Surprisingly low infection and transmission rates were found for Aedes aegypti.
BioCollections Worldwide said today that it is now offering a laboratory-developed test for the detection of Chikungunya virus. The assay follows the US Centers for Disease Control and Preventions real-time RT-PCR protocol for detection of Chikungunya virus, and detects cases in the acute stage of infection in about five hours, BCW said. The Miami-based company is providing the test through its CLIA-certified testing laboratory.
...Recent breakthroughs in Chikungunya research spearheaded by scientists...Chikungunya fever caused by the Chikungunya virus (CHIKV) is a mosq...CHIKV infection is characterised by an abrupt onset of fever frequentl...To devise strategies to stop CHIKV transmission Dr Ngs team collabor...,Breakthroughs,in,Chikungunya,research,from,A*STAR,spell,new,hope,for,better,treatment,and,protection,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
MANHASSET, NY - Lindsay Lohan getting the mosquito-transmitted virus Chikungunya may help shine a light on the seriousness of the virus, according to a New York infectious disease physician.. There is an epidemic of the virus in the Caribbean and a few cases in Florida, says Bruce Hirsch, MD, attending infectious disease physician at North Shore University Hospital in Manhasset.. Ms. Lohan contracted the virus while on vacation in French Polynesia.. Doctors hope her celebrity status reminds us of the importance of learning and preventing emerging health concerns, Dr. Hirsch says. The Chikungunya virus causes fever and arthritis. Older persons with the virus can have painful arthritis for long periods.. In addition to fever and arthritis, some symptoms of Chikungunya include:. ...
Chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes albopictus and Aedes aegypti mosquitoes in tropical areas of Africa, Asia, and the islands of the Indian Ocean. In 2007 and 2009, CHIKV was transmitted outside these tropical areas and caused geographically localized infections in people in Italy and France. To temporally and spatially characterize CHIKV infection of Ae. albopictus midguts, a comparison of viral distribution in mosquitoes infected per os or by enema was conducted. Ae. albopictus infected with CHIKV LR 5′ green fluorescent protein (GFP) at a titer 10[superscript 6.95] tissue culture infective dose[subscript 50] (TCID[subscript 50])/mL, were collected and analyzed for virus dissemination by visualizing GFP expression and titration up to 14 days post inoculation (dpi). Additionally, midguts were dissected from the mosquitoes and imaged by fluorescence microscopy for comparison of midgut infection patterns between orally- and enema-infected mosquitoes. When virus was ...
Chikungunya infection has recently re-emerged as an important arthropod-borne disease in Thailand. Recently, Southern Thailand was identified as a potentially endemic area for the chikungunya virus. Here, we report a case of severe musculoskeletal complication, presenting with muscle weakness and swelling of the limbs. During the investigation to exclude autoimmune muscular inflammation, high titers of antinuclear antibody were detected. This is the report of autoimmunity detection associated with an arbovirus infection. The symptoms can mimic autoimmune polymyositis disease, and the condition requires close monitoring before deciding to embark upon prolonged specific treatment with immunomodulators.
Chikungunya virus (CHIKV) is an arbovirus distributed widely in tropical regions of the world that causes a febrile and often painful disease in adults and children. Recent outbreaks of CHIKV infection in the Caribbean have raised concerns about establishment of this virus in North America. A significant question about the transmission cycle of CHIKV is whether non-human reservoir hosts are important in maintenance or transmission of the virus. We conducted experimental infections with CHIKV and discovered that several reptiles and amphibians developed viremia of sufficient magnitude to possibly serve as reservoir hosts. One or two strains of CHIKV were inoculated into a variety of ball pythons, Burmese pythons, Northern garter snakes, American alligators, green iguanas, painted turtles, leopard frogs, Bufo species toads and cane toads. Viremia was not detected in alligators or cane toads but all other species developed viremia at variable magnitude. Peak viremia in the other species varied from 2.8
We previously proposed a compartmental model to explain the outbreak of Chikungunya disease in Réunion Island, a French territory in Indian Ocean, and other countries in 2005 and possible links with the explosive epidemic of 2006. In the present paper, we asked whether it would have been possible to contain or stop the epidemic of 2006 through appropriate mosquito control tools. Based on new results on the Chikungunya virus, its impact on mosquito life-span, and several experiments done by health authorities, we studied several types of control tools used in 2006 to contain the epidemic. We present an analysis of the model, and we develop a new nonstandard finite difference scheme to provide several simulations with and without mosquito control. Our preliminary study shows that an early use of a combination of massive spraying and mechanical control (like the destruction of breeding sites) can be efficient, to stop or contain the propagation of Chikungunya infection, with a low impact on
The reemergence of Chikungunya virus exemplifies the need to develop new vaccines to target other emerging viral pathogens. Chikungunya is estimated to be responsible for several million human infections in the last decade. In addition, one of its vectors, the Aedes albopictus mosquito, is moving into new regions, meaning the infection rate is expected to…
Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same |i|Aedes|/i| mosquito vectors and thus overlap in their endemic areas. These two viruses also cause similar clinical presentations, especially in the initial stages of infection, with neither virus possessing any specific distinguishing clinical features. Because the outcomes and management strategies for these two viruses are vastly different, early and accurate diagnosis is imperative. Diagnosis is also important for surveillance, outbreak control, and research related to vaccine and drug development. Available diagnostic tests are aimed at detection of the virus, its antigenic components, or the host immune antibody response. In this review, we describe the recent progress and continued challenges related to the diagnosis of DENV and CHIKV infections.
Q: I heard there was a new viral disease from Africa that has just come to the Americas. What is this?A: It sounds like you are referring to the chikungunya virus.Chikungunya (which means stooped walk in a Tanzanian language, named because the joint pain from it makes people walk in a bent over fashion) is a viral illness transmitted by infected mosquitoes (only certain types of mosquitoes can carry this virus). The cycle of infection is: a mosquito bites a person (or certain animals) that
Q: I heard there is a new viral disease from Africa that has just come to the Americas. What is this?A: It sounds like you are referring to the chikungunya virus.Chikungunya (which means stooped walk in a Tanzanian language; named because the joint pain from it makes people walk in a bent-over fashion) is a viral illness transmitted by infected mosquitoes (only certain types of mosquitoes can carry this virus). The cycle of infection is: a mosquito bites a person (or certain
TY - JOUR. T1 - Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses. AU - Kikuti, Mariana. AU - Tauro, Laura B.. AU - Moreira, Patrícia S.S.. AU - Nascimento, Leile Camila J.. AU - Portilho, Moyra M.. AU - Soares, Gúbio C.. AU - Weaver, Scott C.. AU - Reis, Mitermayer G.. AU - Kitron, Uriel. AU - Ribeiro, Guilherme S.. N1 - Funding Information: This study was supported by the Brazilian National Council for Scientific and Technological Development (grants 400830/2013-2 and 440891/2016-7 to GSR; and scholarships to UK, MGR, and GSR); the Bahia Foundation for Research Support (grants PET0026/2013 , APP0044/2016 , and PET0022/2016 to GSR); the Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education (grant 88887.130746/2016-00 to GSR and scholarship to MK); the Oswaldo Cruz Foundation ; the Federal University of Bahia ; and the ...
The number of suspected and confirmed cases of chikungunya virus in Caribbean countries has risen sharply over past weeks, health officials say. According to Karen Weintraub (National Geographic) Chikungunya has plagued other parts of the world-particularly Asia and Africa-for decades, becoming more prevalent in recent years, but it arrived in the Caribbean only in December…
Florida case is unusual. Hirschwerk said he and his colleagues diagnosed chikungunya fever virus within the past six weeks. The Long Island patients were unrelated, he said.. One of those cases has been confirmed by the CDC, Hirschwerk said, and testing is still pending on the others.. The likelihood of having more cases in individuals who have not traveled is very low, Hirschwerk said. The Florida case is unusual and I dont expect to see high numbers [of infections] but we have to keep an eye on the situation.. For some experts, the emergence of chikungunya in Florida sounds an alarm because the virus is carried by mosquito species -- Aedes albopictus and Aedes aegypti-- that are well established in this country.. The two species of Aedes mosquitoes that spread chikungunya are found in the southern and eastern United States, said Dr. Erin Staples, a medical epidemiologist at the CDC.. It is difficult to predict how the disease will spread in the mainland U.S., Staples said, but we ...
Chikungunya fever is a mosquito-borne febrile illness caused by Chikungunya virus (CHIKV), an alphavirus from the Togaviridae family. It is transmitted by primarily Aedes aegytpi and Aedes albopictus mosquitos [1]. Once of little importance in the Am ...
Author Summary Dengue and chikungunya are mosquito-borne diseases that are found in similar geographical areas and present with similar symptoms. As their treatment is different, especially for dengue haemorraghic fever (DHF) which is a more severe form of dengue, it is important for healthcare workers to differentiate between them. We studied 117 chikungunya and 917 dengue adult patients (including 55 with DHF) by comparing their clinical presentation and developed decision trees to classify them using simple symptoms and laboratory tests. From the study, we found that at their first appearance in hospital, more chikungunya patients had muscle or joint pains, and fewer had a sore throat, cough, nausea, vomiting, diarrhea, stomach pain, loss of appetite or fast heart beat than DF or DHF patients. From the decision trees, of DF versus chikungunya using only platelet level cut-offs, we could correctly classify 89% of the cases. For DHF versus chikungunya using platelet level cut-offs and the presence of
Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the development of vaccine candidates is of critical importance. Historically, live-attenuated vaccines (LAVs) for protection against arthropod-borne viruses have been created by blind cell culture passage leading to attenuation of disease, while maintaining immunogenicity. Attenuation may occur via multiple mechanisms. However, all examined arbovirus LAVs have in common the acquisition of positively charged amino acid substitutions in cell-surface attachment proteins that render virus infection partially dependent upon heparan sulfate (HS), a ubiquitously expressed sulfated polysaccharide, and appear to attenuate by retarding dissemination of virus particles in vivo. We previously reported that, like other ...
Chikungunya causes, symptoms, prevention and treatment in Hindi. चिकनगुनिया का कारण, लक्षण, फैलाव और चिकित्सा की जानकारी. Chikungunya ke dard ka upchar, Chikungunya kaise hota hai. Chikungunya ka gharelu upchar. Chikungunya treatment in Hindi.
Chikungunya virus (CHIKV) is an arthropod-borne agent that causes severe arthritic disease in humans and is considered a serious health threat in areas where competent mosquito vectors are prevalent. CHIKV has recently been responsible for several millions of cases of disease, involving over 40 countries. The recent re-emergence of CHIKV and its potential threat to human health has stimulated interest in better understanding of the biology and pathogenesis of the virus, and requirement for improved treatment, prevention and control measures. In this study, we mapped the binding sites of a panel of eleven monoclonal antibodies (mAbs) previously generated towards the capsid protein (CP) of CHIKV. Using N- and C-terminally truncated recombinant forms of the CHIKV CP, two putative binding regions, between residues 1-35 and 140-210, were identified. Competitive binding also revealed that five of the CP-specific mAbs recognized a series of overlapping epitopes in the latter domain. We also identified a
Chikungunya virus (CHIKV) is an arthropod-borne agent that causes severe arthritic disease in humans and is considered a serious health threat in areas where competent mosquito vectors are prevalent. CHIKV has recently been responsible for several millions of cases of disease, involving over 40 countries. The recent re-emergence of CHIKV and its potential threat to human health has stimulated interest in better understanding of the biology and pathogenesis of the virus, and requirement for improved treatment, prevention and control measures. In this study, we mapped the binding sites of a panel of eleven monoclonal antibodies (mAbs) previously generated towards the capsid protein (CP) of CHIKV. Using N- and C-terminally truncated recombinant forms of the CHIKV CP, two putative binding regions, between residues 1-35 and 140-210, were identified. Competitive binding also revealed that five of the CP-specific mAbs recognized a series of overlapping epitopes in the latter domain. We also identified a
The index case of chikungunya virus (CHIKV) in Haiti was reported during early 2014; the vector, the pervasive Aedes aegypti mosquito, promoted rapid spread throughout the country. During December 2014-February 2015, we collected blood samples from 4,438 persons at 154 sites (62 urban, 92 rural) throughout Haiti and measured CHIKV IgG by using a multiplex bead assay. Overall CHIKV seroprevalence was 57.9%; differences between rural (mean 44.9%) and urban (mean 78.4%) areas were pronounced. Logistic modeling identified the urban environment as a strong predictor of CHIKV exposure (adjusted odds ratio 3.34, 95% CI 2.38-4.69), and geographic elevation provided a strong negative correlation. We observed no correlation between age and antibody positivity or titer. Our findings demonstrated through serologic testing the recent and rapid dissemination of the arbovirus throughout the country. These results show the utility of serologic data to conduct epidemiologic studies of quickly spreading mosquitoborne
On September 14, 2015, Pathogens and Global Health journal published online, in an open-access article, details of the first-draft genome sequence of Aedes albopictus, commonly known as the tiger mosquito and responsible for transmitting several deadly diseases to humans, such as dengue fever and chikungunya fever, both carried by viruses, potentially offering hope to millions around the world. This sequencing…offers great hope to our understanding of the mosquito and our ability to control it, potentially saving millions of lives in many areas of the world, said Professor Andrea Crisanti, Editor-in-Chief of Pathogens and Global Health. The Pathogens and Global Health article provides a first look into the genetics of a most dangerous and invasive insect and the possibility of developing ways to prevent the spread of the dengue and chikungunya fevers that infect millions of people annually. The advance is all the more urgent now, given increasingly high levels of mosquito migration and the ...
Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) today announced that EVT894, a monoclonal antibody to treat and potentially prevent chikungunya virus infections, has entered clinical development. The Phase I, randomised, double-blind, single centre, single dose escalation study to evaluate the safety, pharmacokinetics, and immunogenicity of EVT894 vs placebo in healthy volunteers (five dose-cohorts of 8 subjects) is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health with funds from a Phase I Clinical Trial Units for Therapeutics programme award (Contract No. HHSN272201500006I) and is being conducted at Duke Clinical Research Institute (DCRI), at Duke University School of Medicine in Durham, North Carolina, USA.. Chikungunya virus is a mosquito-borne alphavirus that poses a significant threat to public health in tropical and subtropical regions. Chikungunya disease is characterised by ...
Chikungunya virus (CHIKV) is a mosquito-transmitted, single-stranded RNA alphavirus of the Togaviridae family that causes explosive epidemics of a severe febril...
The nsP2 protease of chikungunya virus (CHIKV) is one of the essential components of viral replication and it plays a crucial role in the cleavage of polyprotein precursors for the viral replication process. Therefore, it is gaining attention as a potential drug design target against CHIKV. Based on the recently determined crystal structure of the nsP2 protease of CHIKV, this study identified potential inhibitors of the virus using structure-based approaches with a combination of molecular docking, virtual screening and molecular dynamics (MD) simulations. The top hit compounds from database searching, using the NCI Diversity Set II, with targeting at five potential binding sites of the nsP2 protease, were identified by blind dockings and focused dockings. These complexes were then subjected to MD simulations to investigate the stability and flexibility of the complexes and to gain a more detailed insight into the interactions between the compounds and the enzyme. The hydrogen bonds and hydrophobic
This is a Phase I, open-label, dose-escalation study to examine the safety, tolerability, and immune response to a Virus-Like Particle (VLP) Chikungunya Virus (CHIKV) vaccine in healthy adults ages 18 to 50 years old. The plan is for 25 subjects to receive 3 intramuscular vaccine injections at weeks 0, 4, and 20. The three groups will be enrolled sequentially starting with the lowest dose of 10 micrograms per injection in Group 1.. The hypothesis is that the vaccine is safe and induces immune responses to CHIKV. The primary objective is to evaluate the safety and tolerability of the investigational vaccine, VRC-CHKVLP059-00-VP, at three dosages, 10 micrograms (mcg), 20 mcg, and 40 mcg, in healthy adults. The secondary objective is to evaluate the antibody response against CHIKV VLPs four weeks after the third vaccine injection. The exploratory objectives relate to antigen-specific humoral and cellular immune responses throughout the study. ...
Abstract. Chikungunya virus (CHIKV) is an emerging, mosquito-borne alphavirus that has caused major epidemics in Africa and Asia. We developed chimeric vaccine candidates using the non-structural protein genes of either Venezuelan equine encephalitis virus (VEEV) attenuated vaccine strain TC-83 or a naturally attenuated strain of eastern equine encephalitis virus (EEEV) and the structural genes of CHIKV. Because the transmission of genetically modified live vaccine strains is undesirable because of the potentially unpredictable evolution of these viruses as well as the potential for reversion, we evaluated the ability of these vaccines to infect the urban CHIKV vectors, Aedes aegypti and Ae. albopictus. Both vaccine candidates exhibited significantly lower infection and dissemination rates compared with the parent alphaviruses. Intrathoracic inoculations indicated that reduced infectivity was mediated by midgut infection barriers in both species. These results indicate a low potential for transmission
Link to Pubmed [PMID] - 25739878. Lancet Infect Dis 2015 May;15(5):519-27. Chikungunya is an emerging arthropod-borne disease that has spread from tropical endemic areas to more temperate climates of the USA and Europe. However, no specific treatment or preventive measure is yet available. We aimed to investigate the immunogenicity and safety of a live recombinant measles-virus-based chikungunya vaccine.. http://www.ncbi.nlm.nih.gov/pubmed/25739878 ...
This packet presents raster data files that accompany a manuscript submitted for publication to Philosophical Transactions of the Royal Society, titled Climate Change Influences on Global Vector Distributions for Dengue and Chikungunya Viruses. Included within this packet are the following data sets: • bias_layer.tif - This data layer summarizes the intensity with which Aedes mosquitoes have been sampled worldwide, according to the digital data resources that were accessed for this study. This data layer was used as a bias layer with which to guide background sampling in the Maxent algorithm. • aegypti_present.tif - Ecological niche model for Aedes aegypti under present-day conditions. • aegypti_a1b.tif - Ecological niche model for Aedes aegypti calibrated under present-day conditions, but transferred to SRES A1B conditions for 2050 (see text for details) • aegypti_a2.tif - Ecological niche model for Aedes aegypti calibrated under present-day conditions, but transferred to SRES A2 ...
Public health officials in Florida on Thursday confirmed that two people in the state contracted the mosquito-borne chikungunya virus locally, rather than overseas.
1. DomingoE 2010 Mechanisms of viral emergence. Vet Res 41 38. 2. NijhuisMvan MaarseveenNMBoucherCA 2009 Antiviral resistance and impact on viral replication capacity: evolution of viruses under antiviral pressure occurs in three phases. Handb Exp Pharmacol 299 320. 3. ParrishCRKawaokaY 2005 The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu Rev Microbiol 59 553 586. 4. ZhangCYWeiJFHeSH 2006 Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups. BMC Microbiol 6 88. 5. BraultACPowersAMOrtizDEstrada-FrancoJGNavarro-LopezR 2004 Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein. Proc Natl Acad Sci U S A 101 11344 11349. 6. TsetsarkinKAVanlandinghamDLMcGeeCEHiggsS 2007 A single mutation in chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 3 ...
Researchers have developed a new candidate vaccine to protect against chikungunya virus, a mosquito-borne pathogen that produces an intensely painful and often chronic arthritic disease that has stricken millions of people in India, Southeast Asia and Africa.
The chikungunya virus circulating in parts of India as well as Sri Lanka and South-East Asia could gain the ability to spread more efficiently by combining mutations, becoming super-adapted for tran
As of April 7, 2015, a total of 77 chikungunya virus disease cases have been reported to ArboNET from 21 U.S. states for 2015 (Table 1 & Map). All reported cases occurred in travelers returning from affected areas. No locally-transmitted cases have been reported from U.S. states ...
The U.S. Defense Advanced Research Projects Agency is asking innovators to build models that predict the spread of chikungunya virus across the Americas, and take home $150,000.
The understanding of the current chikungunya burden depends on a better understanding of the mortality associated with this arboviruses. Our findings show excess mortality during chikungunya epidemics in three most affected states in Brazil. The correlation between the incidence of chikungunya and increase in all-cause mortality reinforce the possibility that chikungunya virus has an impact on mortality rates. Similar results have already been found in other chikungunya epidemics in the past decades2,3,4. Incidence of dengue virus was high in all studied areas in the years 2011-2013, used as a baseline5. Therefore, we suggest that the excess deaths should be related to chikungunya infections and not another arbovirus that occurs at the same season. This is the first time that the excess mortality associated with chikungunya by age group has been calculated, and the results are very close to that found in the Reunion Islands epidemic using the data obtained in the death certificates16.. Since the ...
References. 1. Gutierrez-Saravia E, Gutierrez CE. Chikungunya virus in the Caribbean: a threat for all of the Americas. J Pediatric Infect Dis Soc. 2015;4(1):1-3. doi:10.1093/jpids/piv002 [ Links ] 2. Morrison TE. Reemergence of chikungunya virus. J Virol. 2014;88(20):11644-7. doi:10.1128/JVI.01432-14 [ Links ] 3. Garg M, Alcalde V. Update on emerging infections: news from the centers for disease control and prevention. Ann Emerg Med. 2014;64(5):553-5. doi:10.1016/j.annemergmed.2014.07.456 [ Links ] 4. Halstead SB. Reappearance of chikungunya, formerly called dengue, in the Americas. Emerg Infect Dis. 2015;;21(4):557-61. doi:10.3201/eid2104.141723 [ Links ] 5. Carbajo AE, Vezzani D. Waiting for chikungunya fever in Argentina: spatio-temporal risk maps. Mem Inst Oswaldo Cruz. 2015;110(2):259-62. doi:10.1590/0074-02760150005 [ Links ] 6. Pan American Health Organization - PAHO. Cases of Chikungunya Fever in the Americas, 2016 (for week). Washington, DC: Pan American Health Organization; 2016 ...
Via El Vocero de Puerto Rico: Declaran epidemia del virus Chikungunya en la Isla.[Epidemic of chikungunya virus declared on the island] Excerpt, with my translation: El Departamento de Salud declaró una epidemia del virus de Chikungunya en Puerto Rico porque...
Via Stabroek News in Georgetown: Two Chikungunya fever cases confirmed. Excerpt: The Chikungunya mosquito-borne virus, which has been spreading rapidly throughout the Caribbean in the last five months, has surfaced in Guyana and health officials say they have since been...
The Centers for Disease Control and Prevention (CDC) reports that the chikungunya virus has not reached the U.S., but there were confirmed cases on the Caribbean Island of St. Martin in December 2013. At the time of publication, at least three travelers from the U.S. to the Caribbean have contracted the chikungunya virus. It wont be long before the Asian tiger mosquito makes its way onto U.S. soil. The CDC states that other mosquitoes that can spread the chikungunya virus and dengue are in the United States. These mosquitoes include Aedes aegypti and Aedes albopictus. Entomologists have found the species as far south as Floridas Gulf Coast and as far north and west as Chicago, Illinois.. ...
More suspected Chikungunya cases being tested | There are now more than 60 suspected cases of the Chikungunya virus in Barbados. However, the number of…
In the last years, cases of chikungunya fever have been reported in international travellers returning from the Indian Ocean region. The cases have been linked to the re-emergence of chikungunya fever on Indian Ocean islands in 2006. We describe the first case of chikungunya fever in a French traveller returning from Malé, an island of the Maldives islands, confirming the permanence of virus circulation by the end of 2009.
Radionz.co.nz 26 July 2014 The Health Department in American Samoa says it has confirmed the acute rash outbreak as cases of Chikungunya, a virus simil...
SANTO DOMINGO, Dominican Republic - Health authorities in the Dominican Republic have reported the first outbreak of a mosquito-borne virus that has spread quickly in the Caribbean in the weeks since it was first detected in the region.. Health Minister Freddy Hidalgo says blood samples analyzed by the U.S. Centers for Disease Control confirmed the first cases in the country of the virus known as chikungunya.. Health officials said Friday that 150-200 cases have been treated for symptoms since the first incidence was detected March 22. Most were in and around the town of Nigua, west of the capital.. Chikungunya is found mainly in Africa and Asia. It is rarely fatal but can cause fever, rash, fatigue and intense muscle and joint pain. The first Caribbean cases were detected in December in French St. Martin.. ...
So thanks for, thanks for coming and attending this lecture and like Dr. Donovan said I work for the UMPC Center for Health Security which is a unique thing tank focused on catastrophic health events, pandemic preparedness, emerging infectious diseases and Ive been asked to talk about two diseases that have been in the headlines, Chikungunya and MERS, and Im going to give you a little snapshot of Ebola at the end of what the current status is. If you were here last year I spoke entirely about Ebola but here two different diseases that you may or may not be experienced with but are very important to know about. And I talk very fast so raise your hands or slow me down if I talk too fast.. All right, so Chikungunya is not some kind of a nasty type of chicken, its really a disease and it comes from a tribal word to mean to walk bent over because it seizes people with such severe pain that they cannot stand upright and thats what the word means when you hear it. Most people say chicken what, or ...
Soon after starting planning my volunteer trip to Carriacou I was given advice about vaccinations I would require. These were basically for rabies and tetanus. As I was tested and proven that I already had enough anti-bodies against tetanus (Clostridium tetani) all I had to do was to get my rabies shots. Great. Cashed out over £110 for this and thought this was it.. Then later I heard about this Chikungunya virus that was causing issues round the world but it was also prevalent in the Caribbean. Turns out this virus causes a quite nasty disease. OK, not exactly ebola grade badness but can still be lethal in extreme cases and can also cause severe joint pain that can linger for months and even a few years. And, you guessed it, absolutely no vaccine for it.. Want to know more? optimistic version and slightly less cheerful version. ...
Two cases of debilitating Chikungunya virus have turned up in Rhode Island, officials report, continuing a trend of imported cases of the mosquito borne virus across the United States.
This study investigated volatiles released from the feet and trunk of human volunteers and isolated predominantly aldehydes and carboxylic acids as the electrophysiologically-active components using antennae of Ae. aegypti. Electrophysiological activity for some of these aldehydes and carboxylic acids from human skin odors have previously been reported for various mosquito species. For example octanal and nonanal, identified from the human feet, trunk and armpit were reported to elicit electrophysiological response in antennae of Ae. aegypti [22,23] and Aedes mcintoshi [24], a major vector of Rift Valley fever virus, and Culex quinquefasciatus [25], the major vector of West Nile virus in bird headspace volatiles, respectively. Carboxylic acids were reported to elicit EAG responses in Ae. aegypti [22,23], An. gambiae [26] and Cx. quinquefasciatus [27]. These findings emphasize the importance of aldehydes and carboxylic acids in host seeking behavior of Ae. aegypti. Both aldehydes and carboxylic ...
A breakthrough in the treatment of mosquito transmitted viral diseases has been discovered by researchers at Griffith University.
Salvadoran health authorities confirmed Saturday that a dengue-like disease that has been spreading across the Caribbean has now appeared in the Central-American country.
Background Dengue and chikungunya are global re-emerging mosquito-borne diseases. In Singapore, sustained vector control coupled with household improvements reduced domestic mosquito populations for the past 45 years, particularly the primary vector Aedes aegypti. However, while disease incidence was low for the first 30 years following vector control implementation, outbreaks have re-emerged in the past 15 years. Epidemiological observations point to the importance of peridomestic infection in areas not targeted by control programs. We investigated the role of vectors in peri-domestic areas. Methods We carried out entomological surveys to identify the Aedes species present in vegetated sites in highly populated areas and determine whether mosquitoes were present in open-air areas frequented by people. We compared vector competence of Aedes albopictus and Aedes malayensis with Ae. aegypti after oral infection with sympatric dengue serotype 2 and chikungunya viruses. Mosquito saliva was tested ...
Duval County Health Department officials confirmed that a 15-year-old girl has the third local case of chikungunya fever, spread by bites from infected mosquitoes. They also confirmed that a 7-year-old Duval County girl is recovering from this years first reported case of Vibrio vulnificus infection, the so-called flesh-eating bacteria apparently contracted after a swim in the St. Johns River.. Clay County health officials also warned residents that several horses in the county tested positive for Eastern equine encephalitis virus which can spread to humans.. Duval Health Department spokesman Charles Griggs said the public can take precautions in both cases to not put themselves at risk.. The 15-year-old Jacksonville girl recently traveled out of the country. Health officials did not reveal her current condition after the chikungunya infection or where she had traveled, but the disease has been a problem in the Caribbean.. Symptoms include sudden high fever, severe joint pain, headache, ...
Many tropical countries are currently experiencing dengue (DEN), chikungunya (CHIK) and also more recently Zika (ZIKA) epidemics (particularly in Latin America). Although the risk of transmission and spread of these infections in temperate regions remains a controversial issue, vector-borne diseases have been widely reported in the media and have been the focus of preventive strategies by national and international policy-makers and public health authorities. In this context, we wanted to determine the extent of risk perception in infectious diseases (ID) physicians of the current and future risk of arboviral disease introduction, autochthonous case development and epidemic scenarios in France, Western Europe. To this aim, we developed an original standardized questionnaire survey which was disseminated by the French Infectious Diseases Society to ID physician members. We found that ID physicians perceived the risk of introduction and outbreak development of DEN, CHIK and ZIKA in France to be low to
Background. Chikungunya (CHIK-V) is a single-stranded RNA alpha virus of the family Togaviridae, first isolated from mosquitoes and humans during an outbreak in Tanzania in 1952 to 1953. The onset of symptoms of a CHIK-V infection is usually 3-7days after being bitten. Infection elicits an acute febrile and incapacitating Polyarthralgia typically affecting the hands and feet. Other manifestations include headache, myalgia, maculopapular rash, gastrointestinal involvement, and persistent rheumatologic symptoms [1]. The exact pathogenesis that accounts for persistent joint symptoms is uncertain, but it has been proposed that joint involvement may have a relationship with predisposing genetic profiles such as HLA B27 [2]. Macrophage-derived products such as tumor necrosis factor-alpha, interferon-gamma, and macrophage chemo attractant protein-1 may be implicated in the damage of joint tissue. While fatalities associated with CHIK-V infection are rare, more severe clinical presentations have been ...
Chikungunya is a viral disease transmitted by mosquitoes whose clinical feature is the early joint damage. Approximately 8% of patients have chronic arthropathy resembling to the rheumatoid polyarthritis. The EchoCHIK study we propose is in the context of the epidemic in Martinique which began in January 2014. It should give a better understanding of arthritis and juxtaarticular of CHIK and look for signs that may allow ultrasound predict the evolution of chronic arthropathy of CHIK ...
After an airline passenger vomited on a plane, almost half of flight attendants who subsequently worked on the same plane developed gastrointestinal symptoms, and two who submitted stool samples were infected with norovirus, according to a study in Clinical Infectious Diseases. Researchers analyzed data from nine flights over 6 days of a Boeing 777-200 after a passenger vomited on the plane and flight attendants subsequently began getting sick. Eight of the flights were international legs that lasted longer than 10 hours. Of the 77 attendants who worked those flights, 63 provided information, and, of those, 27 (43%) met the case definition for gastroenteritis. The attack rate rose to 79% for crew supervisors and declined over time. Two patients who worked different flights provided stool samples, both of which tested positive for norovirus. The authors write, Findings from our investigation suggest that flight attendants were infected through their work on the airplane, with transmission ...
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BACKGROUND: Many tropical countries are currently experiencing dengue (DEN), chikungunya (CHIK) and also more recently Zika (ZIKA) epidemics (particularly in Latin America). Although the risk of transmission and spread of these infections in temperate regions remains a controversial issue, vector-borne diseases have been widely reported in the media and have been the focus of preventive strategies by national and international policy-makers and public health authorities. In this context, we wanted to determine the extent of risk perception in infectious diseases (ID) physicians of the current and future risk of arboviral disease introduction, autochthonous case development and epidemic scenarios in France, Western Europe. METHODS: To this aim, we developed an original standardized questionnaire survey which was disseminated by the French Infectious Diseases Society to ID physician members. RESULTS: We found that ID physicians perceived the risk of introduction and outbreak development of DEN,
An outbreak of febrile illness occurred in Gabon in 2007, with 20,000 suspected cases. Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented co-infections. Aedes albopictus was identified as the principal vector for the transmission of both viruses.
Puerto Rican health officials declared Thursday an epidemic of chikungunya, a mosquito-borne virus that has shown up in more than 200 confirmed cases across the island as of late last month.
Last week, actress Lindsay Lohan revealed that she had been diagnosed with Chikungunya, an incurable virus transmitted to humans by mosquitoes
Dr. Prosper, who owns and operates a clinic in Port au Prince, was and continues to be, very interested in what Homeopathy has to offer in the way of treating this mosquito borne virus. Spring 2014, he studied ten patients with Chikungunya who had fever and joint pain for at least 2 days prior to treatment. They ranged in age from 8 months to 59 years. He stopped any medications they were using to treat the virus. Each participant was given 3-5 sprays from an atomizer of Eupatorium-perfoliatum 200C in water. He followed up with each patient three days after they had taken the remedy and found that seven out of the ten had dramatically improved. Two patients had partial recovery and one had no change in symptoms. ...
Latest news and research breakthroughs on Chikungunya and Homeopathy. Last updated on Dec 24, 2017 with over 675 News and research items available on the subject. Freely Download - Chikungunya and Homeopathy News Widget
Disease carriers - The Asian tiger mosquito and yellow fever mosquito have the potential to transmit debilitating viruses such as dengue, yellow fever, zika virus and the painful chikungunya virus. These diseases have not been transmitted locally. However, if a person with the virus spends time in an area where these mosquitoes are found, there is an increased chance of an outbreak occurring in Los Angeles County. Currently, many cities across the country are reporting many chikungunya cases from travelers coming back to the U.S. from Mexico, the Caribbean, and Latin America. The Australian backyard mosquito is a concern for the veterinary community since it can transmit canine heartworm ...
Aedes aegypti and Ae. albopictus are the main vectors transmitting dengue and chikungunya viruses. Despite being pathogens of global public health importance, knowledge of their vectors global distribution remains patchy and sparse. A global geographic database of known occurrences of Ae. aegypti and Ae. albopictus between 1960 and 2014 was compiled. Herein we present the database, which comprises occurrence data linked to point or polygon locations, derived from peer-reviewed literature and unpublished studies including national entomological surveys and expert networks. We describe all data collection processes, as well as geo-positioning methods, database management and quality-control procedures. This is the first comprehensive global database of Ae. aegypti and Ae. albopictus occurrence, consisting of 19,930 and 22,137 geo-positioned occurrence records respectively. Both datasets can be used for a variety of mapping and spatial analyses of the vectors and, by inference, the diseases they transmit.
Ease of imaging and abundance of genetic tools make the zebrafish an attractive model host to understand host-pathogen interactions. However, basic knowledge regarding the identity of genes involved in antiviral immune responses is still lagging in this species. We conducted a microarray analysis of the larval zebrafish response to two models of RNA virus infections with very different outcomes. Chikungunya virus (CHIKV) induces a rapid and protective IFN response. Infection with infectious hematopoietic necrosis virus is lethal and is associated with a delayed and inefficient IFN response. A typical signature of IFN-stimulated genes (ISGs) was observed with both viruses, but was stronger for CHIKV. We further compared the zebrafish and human ISG repertoires and made a genomic and phylogenic characterization of the main gene families. We describe a core set of well-induced ISGs conserved across vertebrates, as well as multigenic families diversified independently in each taxon. The conservation ...
Reverse genetics is a critical tool to decrypt the biological properties of arboviruses. However, whilst reverse genetics methods have been usually applied to vertebrate cells, their use in insect cells remains uncommon due to the conjunction of laborious molecular biology techniques and of specific difficulties surrounding the transfection of such cells. To leverage reverse genetics studies in both vertebrate and mosquito cells, we designed an improved DNA transfection protocol for insect cells and then demonstrated that the simple and flexible ISA (Infectious Subgenomic Amplicons) reverse-genetics method can be efficiently applied to both mammalian and mosquito cells to generate in days recombinant infectious positive-stranded RNA viruses belonging to genera Flavivirus (Japanese encephalitis, Yellow fever, West Nile and Zika viruses) and Alphavirus (Chikungunya virus ...
A two-year, $300,000 USD grant from the National Institutes of Health (NIH) - Fogarty International Center will allow researchers to examine the neurodevelopmental impact of the chikungunya virus (CHIKV) in infants in Grenada. In addition, WINDREF, which is based on the St. Georges University campus, has been granted $80,000 USD by the United States Naval Medical Research Center (NMRC) to study the Zika virus in the Southern Caribbean.. Dr. Randall Waechter, Research Grants Coordinator and faculty member in St. Georges Universitys Department of Bioethics, and Dr. Angelle Desiree LaBeaud, Associate Professor at Lucile Packard Childrens Hospital Stanford, will serve as Co-Principal Investigators for the NIH study, which is titled Neurodevelopment and Vector-borne Diseases: Building Research Capacity in the Tropics. They will be assisted by SGU faculty members Barbara Landon and Trevor Noel and also work in conjunction with researchers from Stanford University, Oxford University, and ...
The combination of two mosquito-borne viruses may lead to a stroke, according to a new study from the University of Liverpool. The team has been investigating the link between Zika and chikungunya infection and neurological disease. These two mosquito-borne viruses, which are most prevalent in the tropics, are responsible for large outbreaks of rash and fever in places like Brazil and India. Zika is known to cause brain damage in babies if expectant mothers are infected. According to the new findings, Zika also causes nervous system disease …. Read more... ...
Combating viral spread and their associated disease burden is a tremendous challenge requiring significant research efforts and dedicated measures, in public health, veterinary care, and agriculture strategies. Viral sequence data is a major asset in the characterization of pathogens. Understanding the processes that generate genetic diversity assists in the struggle against viral infections and enhances our understanding of past evolutionary and epidemiological events. It can also help in the identification of the origins of new epidemics, in monitoring the effectiveness of therapeutic strategies, and eventually in predicting the behavior of viral epidemics. Advances in bioinformatics have led to improved approaches to investigating viral outbreaks that ave been successfully applied to viruses including the Human immunodeficiency viruses (HIV), the Ebola virus, the Dengue viruses, the Chikungunya virus and the Influenza virus.. More information on the VEME workshop, please visit the website ...
Unlike most arboviruses that replicate in the cytoplasm of the host cells, ZIKAV replicates in the nucleus. ZIKAV is an enveloped virus with a positive sense, single stranded, 11 kb RNA genome. It contains 5 and 3 untranslated regions flanking a single open reading frame. The single polypeptide is cleaved by cellular and viral proteases into three structural proteins, the binding capsid, and seven non-structural proteins. Infection begins in dendritic cells at the site of inoculation, and spreads to lymph nodes and the bloodstream throughout the host. At present, ZIKAV viral RNA concentrations are detectable in blood specimens collected ,3 days after the onset of illness, and levels are still detectable in some individuals as late as 11 days after illness onset [2].. ZIKAV manifests clinically with headache, rash, fever, joint pain, and malaise; the symptomology resembles that of Dengue, Yellow Fever, West Nile, and Chikungunya viruses. However, it is estimated that only 1 in 4 infected ...
Diseases spread by mosquitoes are growing every year and some of the most prominent ones are ✓Malaria ✓Dengue fever ✓Chikungunya virus ✓Japanese Encephalitis ✓Zika fever ✓Yellow fever ✓Lymphatic Filariasis (Elephantiasis) ✓Ross River Fever. Mosquito bite symptoms are dif-ferent for every disease caused by mosquitoes. Check out diseases caused by mosquitoes at Od-omos.
August 3, 2020. GALVESTON, Texas - A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a Zika virus mutation that may be responsible for the explosive viral transmission in 2015/2016 and for the cause of microcephaly (babies with small heads) born to infected pregnant women. The study is currently available in Proceedings of National Academy of Sciences.. The Zika virus caused a global epidemic in 2015 and 2016. Like West Nile, dengue, yellow fever, and chikungunya viruses, the Zika virus is primarily transmitted by mosquitoes. These viruses pose constant threats to populations living in areas with mosquitoes. Dengue virus alone causes 390 million human infections each year. Because these viruses circulate between mosquitoes and animals/humans, they are prone to genetic mutations, making them highly capable of emerging and causing epidemics.. In this study, the UTMB team has identified a mutation in the Zika envelope protein that can enhance ...
Human HGF plasmid DNA therapy of cardiomyocytes is being examined as a potential treatment for coronary artery disease as well as treatment for the damage that occurs to the heart after myocardial infarction.[9][10] As well as the well-characterised effects of HGF on epithelial cells, endothelial cells and haemopoietic progenitor cells, HGF also regulates the chemotaxis of T cells into heart tissue. Binding of HGF by c-Met, expressed on T cells, causes the upregulation of c-Met, CXCR3, and CCR4 which in turn imbues them with the ability to migrate into heart tissue.[11] HGF also promotes angiogenesis in ischemia injury.[12] HGF may further play a role as an indicator for prognosis of chronicity for Chikungunya virus induced arthralgia. High HGF levels correlate with high rates of recovery.[13]. Excessive local expression of HGF in the breasts has been implicated in macromastia.[14] HGF is also importantly involved in normal mammary gland development.[15][16]. HGF has been implicated in a variety ...
My research interests include x-ray crystallographic studies of viral proteases including Norovirus, Zika virus and Chikungunya virus, computational studies of viral protease structure, compound design and binding efficacy, structure-based drug design of inhibitors against viral proteases, and analysis of the genotypic variations in potency of v. ...
In the United States, A. aegypti has been established for more than 300 years and since 1985 the Southeast of the United States has been invaded by A. albopictus, with a range extending from South Florida to Illinois.10. The adaptation of CHIKV to A. albopictus is a relatively recent event. During the outbreak in the Indian Ocean in 2005-2006 the virus has acquired a mutation at residue 226 of the membrane fusion glycoprotein-1, which allows it to infest A. albopictus. This mutation is likely the cause of the wide spread of the disease.11. Pathogenesis. CHIKV is transmitted predominantly by female mosquito bites. Alternatively the disease can be transmitted vertically from mother to fetus or theoretically by blood transfusion (although no cases have been reported so far).. After the inoculation, the virus invades endothelial cells and subcutaneous fibroblasts and replicates in a limited fashion. Circulating blood cells may be refractory to invasion. New viruses are transported to local lymph ...
The virus was first isolated from an outbreak in Tanzania in 1952. Chikungunya virus is a member of the genus Alphavirus and ... Chikungunya virus , CDC". www.cdc.gov. 17 December 2018. Retrieved 17 March 2020. Chikungunya, WHO, archived from the original ... viruses (dengue and chikungunya, rabies).[citation needed] The World Health Organization recognizes the twenty diseases below ... The word chikungunya is from the Makonde which means "that which bends up", and this refers to the effect of the debilitating ...
Henss L, Scholz T, Grünweller A, Schnierle BS (October 2018). "Silvestrol Inhibits Chikungunya Virus Replication". Viruses. 10 ... Elgner F, Sabino C, Basic M, Ploen D, Grünweller A, Hildt E (March 2018). "Inhibition of Zika Virus Replication by Silvestrol ... January 2017). "The natural compound silvestrol is a potent inhibitor of Ebola virus replication". Antiviral Research. 137: 76- ... ". Viruses. 10 (4): 149. doi:10.3390/v10040149. PMC 5923443. PMID 29584632. Müller C, Schulte FW, Lange-Grünweller K, Obermann ...
There, he reported on a number of pathogens, including Zika, chikungunya, and Hepatitis C. He worked at the Global Virus ... "Global Virus Network Staff". Global Virus Network. Archived from the original on 2015-03-15. Retrieved 6 September 2020. ... McSweegan, E; Weaver, SC; Lecuit, M; Frieman, M; Morrison, TE; Hrynkow, S (August 2015). "The Global Virus Network: Challenging ... Mcsweegan was detailed by the NIH to the Global Virus Network, where he became a program manager. ...
Yellow fever viruses, Dengue fever viruses, and Zika viruses are of the Flavivirus genera and Chikungunya virus is of the ... Chikungunya: The Chikungunya virus is a single stranded RNA alphavirus typically transmitted by the Aedes mosquitoes to another ... The animal reservoir of the virus maintains a suitable virus level in the blood to allow the infection of a vector mosquito. A ... Tsetsarkin, Konstantin A; Chen, Rubing; Weaver, Scott C (February 2016). "Interspecies transmission and chikungunya virus ...
CS1 maint: discouraged parameter (link) Dipali Pathak (30 August 2016). "Grant to develop chikungunya virus vaccine awarded". ... CS1 maint: discouraged parameter (link) "Sabin Institute To Develop GSK's Ebola and Marburg Virus Vaccines". www. ... "Sabin Institute To Develop GSK's Ebola and Marburg Virus Vaccines". www.precisionvaccinations.com. Retrieved 2020-05-20. Miller ...
The four are Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV) and one simply called Ebola virus (EBOV, ... The virus responsible for the initial outbreak, first thought to be Marburg virus, was later identified as a new type of virus ... Main articles: Ebola virus cases in the United States, Ebola virus disease in Spain, and Ebola virus disease in the United ... Virus taxonomy classification and nomenclature of viruses; 8th report of the International Committee on Taxonomy of Viruses. ...
Human prohibitin 1 has some activity as a virus receptor protein, having been identified as a receptor for Chikungunya Virus ( ... "Identification of prohibitin as a Chikungunya virus receptor protein". Journal of Medical Virology. 84 (11): 1757-70. doi: ... CHIKV) and Dengue Virus 2 (DENV-2). Little else is known about the activity of the prohibitins in viral pathogenesis. ...
"Isolation of chikungunya virus contaminating an Aedes albopictus cell line." Journal of General Virology 27.1 (1975): 97-100. ... Her first research "assignment was to study the spread of the polio virus in East Baltimore neighborhoods". After working as a ... "Lassa fever, a new virus disease of man from West Africa." The American journal of tropical medicine and hygiene 19.4 (1970): ... She was the first person to culture Lassa virus, the causative agent of Lassa fever, a potentially deadly disease that ...
"Aedes aegypti mosquito responsible for Chikungunya virus in Karachi: report". Dunya News tv. 21 December 2016. Retrieved 21 ... as thousands of patients were affected by mysterious Chikungunya virus in December, 2016. Despite joint denial by WHO and ... Provincial Government of Sindh discloses that aedes aegypti mosquito is responsible for spreading Chikungunya in the area. The ... "More patients arrive at Karachi hospital with symptoms of mysterious virus". Geo News tv. Retrieved 21 December 2016. " ...
"Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases". Molecular Systems Biology. 14 (8): ... Shoaib; Monga, Isha; Dar, Showkat Ahmad; Singh, Sandeep (2016-09-16). "ZikaVR: An Integrated Zika Virus Resource for Genomics, ... such as pediatric chikungunya, as well as noncommunicable autoimmune diseases. Integrative omics has also been employed ... a multiomic resource for Zika virus data Ecomics, a normalized multi-omic database for Escherichia coli data, GourdBase, ...
"Four cases of acute flaccid paralysis associated with chikungunya virus infection". Epidemiol Infect. 136 (9): 1277-80. doi: ... New Updated Guthrie List Online Morens DM and Fauci AS (2014). "Chikungunya at the Door - Déjà Vu All Over Again?". New England ... Chikungunya', which is derived from the Makonde root verb kungunyala (meaning "that which bends up", "to become contorted," or ...
"Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses". PLoS Neglected Tropical Diseases. pp. e3188. doi:10.1371 ... hensilli is a potential vector of dengue virus and Zika virus and laboratory studies have indicated that it could play a role ... Fritz, C L; Savage, H M; Yolwa, A; Gubler, D J; Vorndam, V; Rutstein, D (1 April 1998). "Epidemic of dengue-4 virus in Yap ...
"Help Control Mosquitoes that Spread Dengue, Chikungunya, and Zika Viruses" (PDF). Chikungunya Virus Home: Fact Sheets and ... "Zika Virus". CDC. 5 November 2014. Retrieved 20 June 2019. "Symptoms, Diagnosis, & Treatment of Zika Virus". Zika Virus Home. ... Zika virus has been isolated from semen samples, with one person having 100,000 times more virus in semen than blood or urine, ... Zika virus is a mosquito-borne flavivirus closely related to the dengue and yellow fever viruses. While mosquitoes are the ...
"Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases". Molecular Systems Biology. 14 (8): ...
Lahariya, C; Pradhan, SK (December 2006). "Emergence of chikungunya virus in Indian subcontinent after 32 years: A review". ...
Notes: Guadeloupe withdrew before the tournament due to outbreak of chikungunya virus. 30 May 2014 18:00 Parc Bayas, Mirebalais ... Notes: Anguilla withdrew before the tournament due to outbreak of chikungunya virus. 18 June 2014 16:00 Estadio Panamericano, ...
Another is focused on the chikungunya virus which is transmitted by mosquitoes. The transaction provides Emergent with a Swiss ... As of the end of June 2016, 60 countries and territories had reported transmission of the Zika virus from mosquitoes. Emergent ... the virus which causes COVID-19. Human testing began in 2020, and the vaccine received Emergency Use Authorization from the FDA ... could become the first company to develop a vaccine for the virus. Emergent spun off its biosciences division in August 2016, ...
"Emergence of chikungunya virus in Indian subcontinent after 32 years: A review". Journal of Vector Borne Diseases. 43 (4): 151- ... The WHO groups dengue and chikungunya fever together, but these are separate conditions. India had chikungunya cases before ... "The resurgence of chikungunya in India". Ideas for India - Evidence based policy. Sudarshan, M.K.; Madhusudana, S.N.; Mahendra ... Muniaraj, M (March 2014). "Fading chikungunya fever from India: beginning of the end of another episode?". The Indian Journal ...
albopictus is known to transmit pathogens and viruses, such as the yellow fever virus, dengue fever, Chikungunya fever, and ... The Asian tiger mosquito was also the transmitter of the virus in the first and only outbreak of Chikungunya fever on the ... Evidently, mutated strains of the Chikungunya virus are being directly transmitted through Ae. albopictus particularly well and ... Tsetsarkin, KA; Vanlandingham, DL; McGee, CE; Higgs, S (2007). "A Single Mutation in Chikungunya Virus Affects Vector ...
Examples are the Zika virus, chikungunya virus, yellow fever and dengue fever. The re-emergence of the viruses has been at a ... Flaviviridae viruses transmissible via vectors like mosquitoes include West Nile virus and yellow fever virus, which are single ... Laboratory blood tests can identify evidence of chikungunya or other similar viruses such as dengue and Zika. Blood test may ... "Testing for Zika Virus". CDC. 2017-08-30. Retrieved 2017-10-01. "Chikungunya". World Health Organization. Retrieved 2017-10-01 ...
"Perinatal Chikungunya Virus-Associated Encephalitis Leading to Postnatal-Onset Microcephaly and Optic Atrophy". The Pediatric ... In addition, viruses such as cytomegalovirus (CMV) or Zika have been shown to infect and kill the primary stem cell of the ... Li, C; Xu, D; Ye, Q; Hong, S; Jiang, Y; Liu, X; Zhang, N; Shi, L; Qin, CF; Xu, Z (7 July 2016). "Zika Virus Disrupts Neural ... A study published in The New England Journal of Medicine has documented a case in which they found evidence of the Zika virus ...
"Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus". Viruses. 11 (4 ... There are also investigation lines that use the vector for vaccines against the Zika virus (ChAdOx1 ZIKV) and the Chikungunya ... virus (ChAdOx1 sCHIKV). The ChAdOx1 vector has been used as a platform for a vaccine against coronavirus disease since the ...
Developed Monoclonal antibodies against JE, Dengue, WN, Chikungunya, Influenza and respiratory syncytial viruses (RSV). ... viruses First visualization of Hepatitis E virus particles, confirmation of the virus as the causative agent of water bore ... Invaluable collection of sera and virus strains: Approx. 260,000 serum samples and >600 strains of viruses isolated from humans ... The Virus Research Center (VRC), Pune came into existence in 1952 under the joint auspices of the ICMR and the Rockefeller ...
Sharma, Rajesh; Kesari, Pooja; Kumar, Pravindra; Tomar, Shailly (2018). "Structure-function insights into chikungunya virus ... "Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site". ... Chikungunya Bacillus subtilis India portal Physics portal Chemistry portal Medicine portal Please see Selected bibliography ...
A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection. Nat. Med. 16(3):334- ... Nabel discovered the first effective vaccine candidates for Ebola, Chikungunya and encephalitis viruses through his approach to ... He developed the first Chikungunya virus vaccine effective in primates and advanced universal influenza vaccines of ... Chikungunya, and Epstein-Barr virus. He led research on viral molecular biology, protein structure, and immunotherapy, which ...
Here is the Clinical features of Chikungunya virus infections compared with dengue virus infections. Diagnosis Several methods ... Dengue and Chikungunya. Chikungunya Chikungunya is one of the neglected tropical diseases of Bangladesh. It is a viral disease ... In the South-East Asia region, Chikungunya virus is maintained in the human population by a human-mosquito-human transmission ... Treatment There is no vaccine to prevent or anti-viral drugs to treat Chikungunya virus. Treatment is directed primarily at ...
Polynesia experienced an 'unprecedented' series of outbreaks (14), along with Chikungunya and Zika virus. In only 7 weeks, in ... therefore their infections may also be due to chikungunya, a coinfection of both, or even other similar viruses. The first ... American visitors to and visitors from dengue-endemic regions will continue to present a potential pathway for the dengue virus ... Relation of disease severity to antibody response and virus recovered". The Yale Journal of Biology and Medicine. 42 (5): 311- ...
Chikungunya, dengue serotype 2, and Zika viruses have also been isolated from Aedes luteocephalus. J.-P. Mutebi, M. B. Crabtree ... mosquitoes (Diptera: Culicidae) to transmit Zika virus". BMC Infectious Diseases. 15: 492. doi:10.1186/s12879-015-1231-2. PMC ...
Viruses such as rubella, parvovirus B19, chikungunya, and HIV infection can also cause septic arthritis. Prosthetic joint ... Other less common cause include specific bacteria as mycobacterium tuberculosis, viruses, fungi and parasites. In children ...
Genus Alphavirus, mit Species Chikungunya-Virus (CHIKV), Mayaro-Virus (MAYV), Ross-River-Virus (RRV), sowie Sindbis-Virus (SINV ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
Lujo virus. References[edit]. *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad "Lassa fever". WHO. March 2016 ... Confirmation is by laboratory testing to detect the virus's RNA, antibodies for the virus, or the virus itself in cell culture. ... The Lassa virus is one of several viruses identified by WHO as a likely cause of a future epidemic. They therefore list it for ... Lassa virus is a member of the Arenavirida family of viruses.[7] Specifically it is an old world arenavirus, which is enveloped ...
"Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.", Virol. J., 7 (52). ... Chikungunya outbreaks (2006). *Pakistani dengue (2006). *Iraqi cholera (2007). *Zimbabwean cholera (2008-2009) ... "Origin of the Measles Virus: Divergence from Rinderpest Virus Between the 11th and 12th Centuries". Virology. 7: 52-55. doi ...
"Impact of Wolbachia on Infection with Chikungunya and Yellow Fever Viruses in the Mosquito Vector Aedes aegypti". PLOS ... Other viral hemorrhagic fevers, such as Ebola virus, Lassa virus, Marburg virus, and Junin virus, must be excluded as the cause ... Viruses reach the stomach of the mosquito, and if the virus concentration is high enough, the virions can infect epithelial ... Yellow fever is caused by yellow fever virus, a 40- to 50-nm-wide enveloped RNA virus, the type species and namesake of the ...
Anthrax is now known to be caused by a bacterium, and rabies is known to be caused by a virus. The microscopes of the time ... a virus, or a prion. At present, the science to understand this process is available but not the technology to perform it.[25] ... could reasonably be expected to show bacteria, but imaging of viruses had to wait until the development of electron microscopes ...
2.0 2.1 2.2 2.3 Chen LH, Wilson ME (October 2010). "Dengue and chikungunya infections in travelers". Curr. Opin. Infect. Dis. ... 4.0 4.1 Rodenhuis-Zybert IA, Wilschut J, Smit JM (August 2010). "Dengue virus life cycle: viral and host factors modulating ... "Dengue virus pathogenesis: an integrated view". Clin. Microbiol. Rev. 22 (4): 564-81. doi:10.1128/CMR.00035-09. பப்மெட் ... arthropod-borne viruses) ஆர்போ எனும் பெயர்கொண்டும் அழைக்கப்படுகின்றன.[3] ...
... is an infection caused by the chikungunya virus (CHIKV).[3] Symptoms include fever and joint pains.[2] These ... Chikungunya virus is passed to humans when a bite from an infected mosquito breaks the skin and introduces the virus into the ... Chikungunya virus (CHIKV), is a member of the genus Alphavirus, and family Togaviridae. It was first isolated in 1953 in ... to those exposed to a high risk of chikungunya infection. No antiviral treatment for Chikungunya virus is currently available, ...
Talk:2013-14 chikungunya outbreak. *Talk:2013-2014 Zika virus outbreaks in Oceania ... Pages in category "Low-importance virus articles". The following 200 pages are in this category, out of approximately 1,493 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Low-importance_virus_articles&oldid=388350164" ...
A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine which prevents infection by respiratory syncytial virus. No ... Mejias, Asuncion; Rodriguez-Fernandez, Rosa; Peeples, Mark E.; Ramilo, Octavio (October 2019). "Respiratory Syncytial Virus ... "Respiratory syncytial virus vaccines". Clinical Microbiology Reviews. 11 (3): 430-9. doi:10.1128/CMR.11.3.430. PMC 88889. PMID ... "The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates" (PDF). The Lancet ...
A92.0) Chikungunya virus disease. *(A92.1) O'nyong-nyong fever. *(A92.2) Venezuelan equine fever ... B20-B24) Human immunodeficiency virus (HIV) disease[संपादित करें]. *(B20.) Human Immunodeficiency Virus (HIV) disease Resulting ... B24.) Unspecified Human Immunodeficiency Virus (HIV) Disease. (B25-B34) Other viral diseases[संपादित करें]. *(B25.) ... B21.) Human Immunodeficiency Virus (HIV) disease Resulting in malignant neoplasms *(B21.0) HIV disease resulting in Kaposi's ...
There are many adjuvants, some of which are inorganic (such as alum), that also carry the potential to augment immunogenicity.[7][8] Two common salts include aluminium phosphate and aluminium hydroxide. Aluminium salts are the most commonly-used adjuvants in human vaccines. Their adjuvant activity was described in 1926.[9] The precise mechanism of alum action remains unclear but some insights have been gained. For instance, alum can trigger dendritic cells (DC) and other immune cells to secrete interleukin-1β (IL-1β), an immune signal that promotes antibody production. Alum adheres to the cell's plasma membrane and rearranges certain lipids there. Spurred into action, the DC picks up the antigen and speeds to a lymph node, where it sticks tightly to a helper T cell and presumably induces an immune response. A second mechanism depends on alum killing immune cells at the injection site although researchers aren't sure exactly how alum kills these cells. It has been speculated that the dying ...
The fifth reassortant virus expresses the attachment protein VP4, (type P1A), from the human rotavirus parent strain and the ... Rotavirus antigens for parenteral delivery, such as the P2-VP8 candidate, can be expressed as virus-like particles prepared in ... Both are taken orally and contain disabled live virus. ... and killed virus. These novel approaches are being pursued ...
HGF may further play a role as an indicator for prognosis of chronicity for Chikungunya virus induced arthralgia. High HGF ... "Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony ...
Chikungunya outbreaks Chikungunya virus [85]. , 50 Pakistan 2006 2006 dengue outbreak in Pakistan dengue fever [86]. ... 2015-16 Zika virus epidemic Zika virus. Hundreds (as of 1 April 2016[update]) Africa 2016 2016 yellow fever outbreak in Angola ... 2013-14 chikungunya outbreak Chikungunya [114]. 40 Madagascar 2014-present 2014 Madagascar plague outbreak Bubonic plague [115] ... 2018 Nipah virus outbreak Nipah virus infection 1,743 (as of 21 July 2019[update]) Democratic Republic of the Congo & Uganda ...
කුඩා ළමුන්ගේ ප්‍රතිශක්තිකරණ පද්ධතිය එන්නත් කිරීමකින් පසුව ඒ සදහා ප්‍රතිශක්තිකරණ ක්‍රියාවලීන් ඇති කිරීමට සමත් අන්දමට වර්ධනය වූ පසුව එන්නත් ලබාදීම මගින් රෝග සඳහා ආරක්ෂාව ලබාදිය හැකිය. අමතර එන්නත් වර්ග ලබාදීම මගින් පුර්ණ ප්‍රතිශක්තීකරණය ලබාදීමට පුළුවන. මෙමගින් සංකීර්ණ එන්නත් වැඩසටහනක් නිර්මාණය වුණි. ඇමරිකා එක්සත් ජනපදයෙහි ප්‍රතිශක්තීකරණ ක්‍රියාවලිය හා සම්බන්ධ උපදේශාත්මක ...
This virus-related article is a stub. You can help Wikipedia by expanding it. *v ... The first hantavirus vaccine was developed in 1990 initially for use against Hantaan River virus which causes one of the most ... They include a recombinant vaccine and vaccines derived from HTNV and PUUV viruses. However, their prospects are unclear.[1] ... Other hantaviruses for which the vaccine is used include Seoul (SEOV) virus. However the vaccine is thought not to be effective ...
... is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever.[66] ... abamectin and ivermectin as antivirals against chikungunya and other alphaviruses". Antiviral Research. 126: 117-24. doi: ...
Variola virus Smallpox was caused by infection with Variola virus, which belongs to the genus Orthopoxvirus, the family ... While the Dryvax virus was cultured in the skin of calves and freeze-dried, ACAM2000s virus is cultured in kidney epithelial ... During the 19th century, the cowpox virus used for smallpox vaccination was replaced by vaccinia virus. Vaccinia is in the same ... In 2017, Canadian scientists recreated an extinct horse pox virus to demonstrate that the smallpox virus can be recreated in a ...
ഹീമൊഫെലസ് ഇൻഫ്ലുവെൻസെ ടൈപ്പ് ബി വാക്സിൻ (Haemophelus influenzae type B) (HIB) അണുബാധ തടയുന്നതിനുള്ള പ്രതിരോധ മരുന്നാണു Haemophelus influenzae type B വാക്സിൻ. ഈ വാക്സിനെ ഒരു ദൈനംദിന വാക്സിനേഷൻ പ്രക്രിയയിൽ ഉൾപെടുത്തിയിട്ടുള്ള രാജ്യങ്ങളിൽ HIB അണുബാധ 90% ൽ അധികം കുറഞ്ഞിട്ടുണ്ട് അതുകൊണ്ടുതന്നെ മെനിഞ്ചൈറ്റിസ്, ന്യൂമോണിയ, എപ്പിഗ്ലൊട്ടിസ് എന്നീ രോഗങ്ങളും കുറഞ്ഞിട്ടുണ്ട്.[1] ...
MC is caused by a poxvirus called the molluscum contagiosum virus (MCV).[1] The virus is spread either by direct contact ... Molluscum contagiosum virus spread by direct contact or contaminated objects[4]. Risk factors. Weak immune system, atopic ... Rubella virus *Rubella. *Congenital rubella syndrome ("German measles" ). *Alphavirus infection. *Chikungunya fever ... Chen, X; Anstey, AV; Bugert, JJ (October 2013). "Molluscum contagiosum virus infection". Lancet Infectious Diseases. 13 (10): ...
Lassa viruses[12][13] are enveloped, single-stranded, bisegmented, ambisense RNA viruses. Their genome[14] is contained in two ... Lassa virus is an emerging virus and a select agent, requiring Biosafety Level 4-equivalent containment. It is endemic in West ... The life cycle of Lassa virus is similar to the Old World arenaviruses. Lassa virus enters the cell by the receptor-mediated ... "Viruses. 4: 2031-2048. doi:10.3390/v4102031. PMC 3497040. PMID 23202452.. *^ a b Donaldson, Ross I. (2009). The Lassa Ward:One ...
This is to keep the virus in circulation thereby exposing the population to the virus at an early age, when it is less harmful ... After a chickenpox infection, the virus remains dormant in the body's nerve tissues. The immune system keeps the virus at bay, ... "Understanding Viruses (2nd ed.). Jones & Bartlett. p. 459. ISBN 978-0-7637-8553-6. . Archived from the original on 1 October ... Rubella virus *Rubella. *Congenital rubella syndrome ("German measles" ). *Alphavirus infection. *Chikungunya fever ...
Chikungunya vaccine[5]. *Dengue vaccine for humans[6]. *Eastern Equine encephalitis virus vaccine for humans[7] ... Virus. Diseases or conditions. Vaccine(s). Brands Hepatitis A virus. Hepatitis A. Hepatitis A vaccine. Havrix, Avaxim, VAQTA, ... Polio virus. Poliomyelitis. Polio vaccine. Kinrix, Quadracel, Pediarix, Pentacel, Pediacel, Ipol Rabies virus. Rabies. Rabies ... Variola virus. Smallpox. Smallpox vaccine. Dryvax, ACAM2000, Imvanex Yellow fever virus. Yellow fever. Yellow fever vaccine. YF ...
Text is available under the Creative Commons Attribution/Share-Alike License and the GFDL; additional terms may apply. See Terms of Use for details ...
Nora virus, nodavirus Flock house, virus da parálise do grilo, virus Chikungunya, e virus do Nilo occidental.[18][19][20] No ... As moscas infectadas pola bacteria son máis resistentes a virus de ARN como o virus de Drosophila C, ... 2009). "A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium". Cell 139 (7): 1268-78 ... Hedges, Lauren; Brownlie, Jeremy; O'Neill, Scott; Johnson, Karyn (2008). "Wolbachia and Virus Protection in Insects". Science ...
... and rubella viruses and the influenza virus.[30] Some viruses such as HIV, dengue, and chikungunya do not have vaccines ... Examples of viruses that undergo this process are herpes simplex virus, human immunodeficiency virus, and vaccinia virus.[44] ... VirusesEdit. Main article: Virus. Viruses are small particles, typically between 20 and 300 nanometers in length,[15] ... "Symptoms, Diagnosis, & Treatment , Chikungunya virus , CDC". www.cdc.gov. 2018-12-17. Retrieved 2019-11-06.. ...
Infection with this virus is thought to be lifelong, but a healthy immune system will keep the virus in check. Many people ... When the virus enters into lytic replication, thousands of virus particles can be made from a single cell, which usually ... When the virus reactivates into lytic replication, it is believed that the virus genome is replicated as a continuous linear ... The mechanisms by which the virus is contracted are not well understood. Healthy individuals can be infected with the virus and ...
Chikungunya virus, HIV, or viral hepatitis. However, whether these virus infections trigger the expansion of adaptive NKG2C+ NK ... For NK cells to defend the body against viruses and other pathogens, they require mechanisms that enable the determination of ... NK cells provide rapid responses to virus-infected cells, acting at around 3 days after infection, and respond to tumor ... The distinction between apoptosis and cell lysis is important in immunology: lysing a virus-infected cell could potentially ...
ഈ ഫലകവും ഇതേ രീതിയിലെ മറ്റൊരു ഫലകവും കൂടി ഒരു താളിൽ ചേർത്താൽ, ഫലകത്തിന്റെ ഉള്ളടക്കത്തെ മറച്ചുവെച്ച് പ്രധാന തലക്കെട്ട് മാത്രമായി കാണിക്കാൻ ഇങ്ങനെ ഉപയോഗിക്കുക ...
Rubella virus *Rubella. *Congenital rubella syndrome ("German measles" ). *Alphavirus infection. *Chikungunya fever ... The virus attacks compromised skin through direct contact, possibly entering through tiny cuts and abrasions in the stratum ... is a new wart treatment which may trigger a host immune response to the wart virus, resulting in wart resolution. It is now ...
Information on Chikungunya virus. Provided by the U.S. Centers for Disease Control and Prevention. ... chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will ... Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and ... When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with ...
Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Arthropod species & virus source(a) Method of Infection log10/ml (b) Incubation period (c) Transmision by bite (d) Assay of ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ...
Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ...
The name chikungunya (pronounced chik-en-gun-ye) is an African word meaning bent ... Chikungunya is a virus passed to humans by the bite of infected mosquitoes. Symptoms include fever and severe joint pain. ... How Chikungunya Can Spread. Mosquitoes spread the virus to humans. Mosquitoes pick up the virus when they feed on infected ... Chikungunya virus. www.cdc.gov/chikungunya. Updated December 17, 2018. Accessed May 29, 2019. ...
Read information written by doctors about Chikungunya virus infection transmission (how you get it), common symptoms are fever ... What are Chikungunya virus infection symptoms and signs?. *How do health care professionals diagnose Chikungunya virus ... What are Chikungunya virus infection symptoms and signs?. *How do health care professionals diagnose Chikungunya virus ... home/infectious disease health center/infectious disease a-z list/chikungunya virus infection center /chikungunya virus ...
Phylogenetic relationships among chikungunya virus isolates from cases of chikungunya fever in France, based on complete E2-6K- ... Chikungunya virus, southeastern France.. Grandadam M1, Caro V, Plumet S, Thiberge JM, Souarès Y, Failloux AB, Tolou HJ, Budelot ... In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes ... viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus ...
Chikungunya virus infection: an overview.. Caglioti C1, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L. ... Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus belonging to the Togaviridae family, first isolated in Tanzania ... Diagnosis is based on the detection of virus by molecular methods or by virus culture on the first days of infection, and by ... Differential diagnosis should take into account the cross-reactivity with other viruses from the same antigenic complex (i.e. ...
... the chikungunya virus had infected at least 200 people. But in the last week alone, it infected more than twice that number. ... Other famous examples include the West Nile virus and dengue fever. Both dengue and the chikungunya virus are spread by the ... From early December to mid-January, the chikungunya virus had infected at least 200 people, epidemiologists say. But in the ... The virus is not usually fatal, though, with 1 death in every 1,000 cases, and then usually only in the elderly or immune- ...
Read information written by doctors about Chikungunya virus infection transmission (how you get it), common symptoms are fever ... What are Chikungunya virus infection symptoms and signs?. *How do health care professionals diagnose Chikungunya virus ... Chikungunya Virus (Chikungunya Infection). *Medical Author: Charles Patrick Davis, MD, PhD *Medical Editor: Melissa Conrad ... The infection caused by Chikungunya virus is was first described in East Africa in 1952. The virus is transmitted by mosquitoes ...
Information on Chikungunya virus. Provided by the U.S. Centers for Disease Control and Prevention. ... Laboratory-confirmed chikungunya virus disease cases reported to ArboNET by state or territory - United States. Travel- ... Chikungunya virus disease cases* reported to ArboNET by states and territories - United States, 2020 (as of February 4, 2021). ... Chikungunya virus disease became a nationally notifiable condition in 2015. Cases are reported to CDC by state and local health ...
... raising the prospect of the virus spreading across the Americas ... Caribbean has reported locally acquired cases of chikungunya, ... Threatwatch: Chikungunya virus spreads in the Americas. Threatwatch is your early warning system for global dangers, from ... A dozen people on the tiny Caribbean island of St Martin have been infected with the chikungunya virus. It is the first time ... But blood samples sent for testing in France confirmed the presence of chikungunya. The virus would have been brought to the ...
... assay follows the US Centers for Disease Control and Preventions real-time RT-PCR protocol for detection of Chikungunya virus ... BioCollections Worldwide said today that it is now offering a laboratory-developed test for the detection of Chikungunya virus ... BioCollections Worldwide said today that it is now offering a laboratory-developed test for the detection of Chikungunya virus ... assay follows the US Centers for Disease Control and Preventions real-time RT-PCR protocol for detection of Chikungunya virus ...
Chikungunya virus has made its appearance well known in the United States this year. In fact, cases have gone from a normal 28 ... The virus was first recorded in 1952 in Africa then Asia, but in 2013 it began to spread to the Caribbean and Haiti. Travelers ... The virus is transmitted by mosquito, but not human to human. Fortunately, it isnt fatal, but it is extremely painful. ... Chikungunya causes a rash, fever, and excruciating joint pain that last from five to seven days. However, Dr. William Schaffner ...
Public health officials in Florida on Thursday confirmed that two people in the state contracted the mosquito-borne chikungunya ... Two Contract Mosquito-Borne Chikungunya Virus in Florida. Puerto Rico Declares Chikungunya Epidemic With Over 100 Confirmed ... The virus, which is transmitted from mosquitoes to humans and vice versa, has been spreading rapidly through the Caribbean ... health officials in Florida said Thursday that two people in the state contracted the mosquito-borne chikungunya virus locally ...
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A mosquito-borne virus that has sickened tens of thousands of people throughout the Carribbean is now threatening the U.S., ... The chikungunya virus - or chik-v - causes high fever and severe pain, and there is no vaccine to prevent it, CBS News ... this virus, back to the United States, Dr. Schaffner said. We have the kind of mosquito that will transmit this virus here in ... A mosquito-borne virus that has sickened tens of thousands of people throughout the Carribbean is now threatening the U.S., ...
... a virus transmitted by Aedes spp mosquitoes--has re-emerged in Africa, southern and southeastern Asia, and the Indian Ocean ... Chikungunya: a re-emerging virus Lancet. 2012 Feb 18;379(9816):662-71. doi: 10.1016/S0140-6736(11)60281-X. Epub 2011 Nov 17. ... In the past decade, chikungunya--a virus transmitted by Aedes spp mosquitoes--has re-emerged in Africa, southern and ... The virus is endemic to tropical regions, but the spread of Aedes albopictus into Europe and the Americas coupled with high ...
PATHOGENICITY/TOXICITY: Translated from the African dialect of Swahili or Makonde, chikungunya means, "that which bends up" (1 ... SUSCEPTIBILITY TO DISINFECTANTS: No information specific to CHIKV; however, most lipid enveloped viruses are sensitive to 70% ( ... SYNONYM OR CROSS REFERENCE: CHIKV (1-6), CHIK (2, 7-9), and chikungunya fever (2, 10). ... the virus was isolated repeatedly from numerous countries in Central and Southern Africa, including Sudan, Uganda, Democratic ...
Mayaro virus (MAYV), Ross River virus (RRV), Sagiyama virus, Semliki Forest virus (SFV) and Una virus (SI Appendix, Fig. S9B). ... Environmental Research Institute for the generous gifts of the Chikungunya virus Ross strain and Chikungunya virus East African ... Dynamics of chikungunya virus cell entry unraveled by single-virus tracking in living cells. J. Virol. 90, 4745-4756 (2016).. ... Chikungunya virus (CHIKV), a single-stranded positive-sense RNA envelope virus, is an emerging alphavirus transmitted to humans ...
Defense Advanced Research Projects Agency is asking innovators to build models that predict the spread of chikungunya virus ... DARPAs challenge, called CHIKV (which stands for chikungunya virus), aims to find ways to forecast the spread of the virus, ... This image shows magnified particles of the Chikungunya virus, which is spread by mosquitos. The virus was found in the ... How Will Chikungunya Virus Spread? DARPA Announces Challenge. By Bahar Gholipour 15 August 2014. ...
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and ... Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and ... Guillain-Barre syndrome Chikungunya virus Plasmapharesis Mosquito-borne diseases This is a preview of subscription content, log ... Chandak NH, Kashyap RS, Kabra D et al (2009) Neurological complications of chikungunya virus infection. Neurol India 57:177-180 ...
The chikungunya virus circulating in parts of India as well as Sri Lanka and South-East Asia could gain the ability to spread ... Super-adapted chikungunya virus a possibility N. Gopal Raj June 25, 2014 21:59 IST Updated: June 25, 2014 21:59 IST ... The chikungunya virus circulating in parts of India as well as Sri Lanka and South-East Asia could gain the ability to spread ... Although the E2-K252Q mutation has continued to turn up in chikungunya viruses isolated in Kerala, the E2-L210Q had not been ...
Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus. ... Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic. ... Chikungunya (CHIKV) has been the cause of multiple outbreaks and infects greater than one million people every year. CHIKV was ... which increases the need to better understand the sequence diversity of these viruses and how any viral mutations affect the ...
... Chikungunya (pronunciation: chik-en-gun-ye) virus is transmitted to people by mosquitoes. The most common ... There is no vaccine to prevent or medicine to treat Chikungunya virus. If you believe you have Chikungunya, prevent mosquito ... Chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will ... During the first week of infection, Chikungunya virus can be found in the blood and passed from an infected person to a ...
Mexico has detected its first domestic case of the painful mosquito-borne viral disease chikungunya in the southwest of the ... Chikungunya, a virus more commonly found in Africa and Asia and transmitted by the aedes aegypti mosquito that causes dengue ... Mexico detects first case of mosquito-borne chikungunya virus. Published November 17, 2014. Reuters ... Chikungunya has already appeared in much of the Caribbean, Central America and the United States. A handful of people have had ...
... a mosquito-bourne virus common in Africa and Asia. ... Faster, cheaper test developed for chikungunya virus. By: ... Chikungunya virus is spread by mosquitoes. It causes high fevers and severe pain in ankle and wrist joints. The disease affects ... Chikungunya virus is spread by mosquitoes. It causes high fevers and severe pain in ankle and wrist joints. The disease affects ... Faster, cheaper test developed for chikungunya virus. By Sanjit Bagchi. Researchers from Japan and India have developed a rapid ...
Chikungunya fever is a self-remitting febrile viral illness that has been associated with frequent outbreaks in tropical ... encoded search term (Chikungunya Virus) and Chikungunya Virus What to Read Next on Medscape ... Research into development of a live-virus and attenuated-virus vaccine against Chikungunya virus is ongoing. However, no ... Zika and chikungunya: mosquito-borne viruses in a changing world. Ann N Y Acad Sci. 2017 Jul. 1399 (1):61-77. [Medline]. ...
These two viruses also cause similar clinical presentations, especially in the initial stages of infection, with neither virus ... and Chikungunya virus (CHIKV) are arboviruses that share the same ,i,Aedes,/i, mosquito vectors and thus overlap in their ... Available diagnostic tests are aimed at detection of the virus, its antigenic components, or the host immune antibody response ... Because the outcomes and management strategies for these two viruses are vastly different, early and accurate diagnosis is ...
  • Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus belonging to the Togaviridae family, first isolated in Tanzania in 1952. (nih.gov)
  • PATHOGENICITY/TOXICITY: Translated from the African dialect of Swahili or Makonde, chikungunya means, "that which bends up" (1, 2, 12), "what bends" (10), or "to walk bent over" (13), and refers to the effect of the incapacitating arthralgia experienced by patients with CHIKV fever (1). (msdsonline.com)
  • Chikungunya virus (CHIKV) is a significant human pathogen that causes debilitating and long-lasting arthritis. (pnas.org)
  • Chikungunya virus (CHIKV) is an emerging viral pathogen that causes both acute and chronic debilitating arthritis. (pnas.org)
  • DARPA's challenge , called CHIKV (which stands for chikungunya virus), aims to find ways to forecast the spread of the virus, and predict future outbreaks in the Caribbean, along with North, Central and South America. (livescience.com)
  • Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and occasional neurologic disease. (springer.com)
  • 2010) A child with serious chikungunya virus (CHIKV) infection requiring intensive care, after an outbreak. (springer.com)
  • I think it is important to do comprehensive surveillance to monitor both CHIKV [chikungunya virus] evolution and rates of herd immunity and disease incidence. (thehindu.com)
  • Chikungunya (CHIKV) has been the cause of multiple outbreaks and infects greater than one million people every year. (jcvi.org)
  • 1,776 inhabitants to determine chikungunya virus (CHIKV) thralgia is often severely debilitating and may last for seroprevalence, identify factors associated with expo- sure, and estimate the symptomatic infection rate. (cdc.gov)
  • After the introduction of CHIKV into the Carib- ciodemographic and clinical data by interview and tested bean region in 2013, the virus spread rapidly, caus- serum samples for CHIKV IgG. (cdc.gov)
  • Dengue virus (DENV) and Chikungunya virus (CHIKV) are arboviruses that share the same Aedes mosquito vectors and thus overlap in their endemic areas. (hindawi.com)
  • Dengue virus (DENV) and Chikungunya virus (CHIKV) are single-stranded, positive-sense RNA viruses. (hindawi.com)
  • While DENV and CHIKV present similarly as an acute febrile illness, these two viruses have vastly different management strategies and outcomes. (hindawi.com)
  • Chikungunya virus (CHIKV) is an arthropod-borne alphavirus (family Togaviridae ) and is the causative agent of chikungunya fever. (wur.nl)
  • The mosquito-transmitted Chikungunya virus (CHIKV) is associated with increased morbidity and debilitating chronic musculoskeletal disease in infected humans. (springer.com)
  • Chikungunya virus (CHIKV, family Togaviridae, genus Alphavirus) was first isolated during an epidemic in Tanzania in 1952 and 1953 (1). (thefreelibrary.com)
  • CHIKV and dengue virus (DENV) are both transmitted by Aedes mosquitoes, such as A. aegypti and A. albopictus. (thefreelibrary.com)
  • A new method of vaccine creation for Chikungunya virus (CHIKV) using a technique called large scale random codon re-encoding was developed by researchers. (medindia.net)
  • Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. (plos.org)
  • Chikungunya virus (CHIKV) is an arthropod-borne virus that belongs to the Alphavirus genus. (plos.org)
  • Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. (archives-ouvertes.fr)
  • Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic disease and chronic arthritis. (pnas.org)
  • Chikungunya virus (CHIKV) is an arbovirus capable of causing a severe and often debilitating rheumatic syndrome in humans. (jci.org)
  • This virus, which we term SKE, displayed diminished replication in skeletal muscle cells in a mouse model of CHIKV disease. (jci.org)
  • To the Editor: Chikungunya virus (CHIKV) first emerged in Indian Ocean islands off the eastern coast of Africa in 2005 and was responsible for large-scale epidemics on the islands of Reunion, Comoros, Mayotte, Mauritius, Madagascar, and Seychelles (1-4). (thefreelibrary.com)
  • To report demographic and self-reported clinical characteristics associated with persistent and severe arthralgia 8-12 months post-chikungunya virus (CHIKV) infection. (uwi.edu)
  • Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics. (nih.gov)
  • Chikungunya fever is an acute febrile illness caused by the chikungunya virus (CHIKV), which is transmitted to humans by Aedes mosquitoes. (eurosurveillance.org)
  • This enables estimation of the current total population-at-risk of CHIKV transmission and identification of areas where the virus may spread to in the future. (eurosurveillance.org)
  • The Ross River Virus (RRV) and Chikungunya Virus (CHIKV) are mosquito-borne alphavirus infections. (medindia.net)
  • Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. (jimmunol.org)
  • Chikungunya virus (CHIKV) is a re-emerging mosquito-borne enveloped alphavirus in the Togaviridae family. (jimmunol.org)
  • Historically, CHIKV was transmitted principally by Aedes aegypti mosquitoes, but in 2006 the virus acquired a single mutation (A226V) in the E1 protein that facilitated enhanced replication and transmission in Aedes albopictus mosquitoes, which expanded its geographical range ( 5 ). (jimmunol.org)
  • After inoculation of CHIKV into the skin, the virus likely replicates in fibroblasts, mesenchymal cells, and osteoblasts ( 20 , 21 ). (jimmunol.org)
  • The Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that can cause widespread outbreaks of a debilitating arthritis-like human disease. (sciencephoto.com)
  • Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblasts. (asm.org)
  • Chikungunya virus (CHIKV) causes a febrile disease associated with chronic arthralgia, which may progress to neurological impairment. (asm.org)
  • Chikungunya fever (CF) is an ongoing public health problem in tropical and subtropical regions of the world, where control of the CHIKV vector, Aedes mosquitos, has failed. (asm.org)
  • The rheumatic symptoms associated with chikungunya virus (CHIKV) infection include polyarthralgia, polyarthritis, morning stiffness, joint edema, and erythema. (mdpi.com)
  • Chikungunya virus (CHIKV) is a small (60-70 nm, 12 Kb), single-stranded positive-sense RNA virus in the Alphavirus genus of the Togaviridae family [ 1 , 2 ]. (mdpi.com)
  • Chikungunya virus (CHIKV) is a positive-sense RNA virus transmitted by Aedes mosquitoes. (mdpi.com)
  • CHIKV establishes a persistent infection in NHPs, particularly in cynomolgus macaques, because infectious virus could be recovered from spleen, liver, and muscle as late as 44 days post infection. (mdpi.com)
  • Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus that causes acute febrile illness and severe debilitating joint pain. (mdpi.com)
  • CHIKV belongs to the Semliki Forest virus clade of Old World Alphaviruses [ 1 , 2 ]. (mdpi.com)
  • In 2006, an outbreak of Chikungunya virus (CHIKV) of the Asian genotype affected over 200 people in Bagan Panchor village in Malaysia. (ajtmh.org)
  • albopictus highlighting the co-ancestry of the different derived populations and the dissemination and transmission efficiencies for Chikungunya virus (CHIKV). (pasteur.fr)
  • Chikungunya virus (CHIKV) has been detected sporadically since the 1950s and includes three distinct co-circulating genotypes. (jcvi.org)
  • Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. (asm.org)
  • Zika virus (ZIKV) and chikungunya virus (CHIKV) are highly pathogenic arthropod-borne viruses that present a serious health threat to humans. (wur.nl)
  • aegypti was competent for both viruses with transmission rates up to 73% (ZIKV) and 21% (CHIKV). (wur.nl)
  • FORT COLLINS, Colo.--(BUSINESS WIRE)--Inviragen, Inc. today announced that the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health, has awarded a four-year grant of over $3 million for the characterization and development of a novel recombinant chikungunya virus (CHIKV) vaccine. (fiercebiotech.com)
  • Background: Chikungunya virus (CHIKV) is a major threat to Australia given the distribution of competent vectors, and the large number of travellers returning from endemic regions. (worldaidsday.org.au)
  • Results: Between 2002 and 2012, there were 168 cases of chikungunya virus (CHIKV) imported into Australia. (worldaidsday.org.au)
  • There is no vaccine to prevent or medicine to treat chikungunya virus infection. (cdc.gov)
  • The infection caused by Chikungunya virus is was first described in East Africa in 1952. (medicinenet.com)
  • Is Chikungunya virus infection contagious? (medicinenet.com)
  • Chikungunya virus infection is not considered to be contagious because there is no direct human to human transfer of Chikungunya viruses, so infected individuals cannot directly transfer the virus to another human because the virus has to pass through a mosquito first. (medicinenet.com)
  • What are Chikungunya virus infection symptoms and signs? (medicinenet.com)
  • The Chikungunya disease may be diagnosed by blood antibody tests that distinguish between this infection and dengue fever , a similar viral disease, and other diseases. (medicinenet.com)
  • Chikungunya virus infection: an overview. (nih.gov)
  • Diagnosis is based on the detection of virus by molecular methods or by virus culture on the first days of infection, and by detection of an immune response in later stages. (nih.gov)
  • What is the treatment for Chikungunya virus infection? (rxlist.com)
  • Once a person recovers from Chikungunya infection, researchers suggest the person develops life-long immunity to the virus type. (rxlist.com)
  • Is it possible to prevent a Chikungunya virus infection? (rxlist.com)
  • The assay follows the US Centers for Disease Control and Prevention's real-time RT-PCR protocol for detection of Chikungunya virus, and detects cases in the acute stage of infection in about five hours, BCW said. (genomeweb.com)
  • Both groups of researchers found a potential means to stop T cells from inappropriately trafficking to the joints and causing arthritis, a hallmark of acute Chikungunya virus infection - using a mouse model of the disease. (eurekalert.org)
  • Chandak NH, Kashyap RS, Kabra D et al (2009) Neurological complications of chikungunya virus infection. (springer.com)
  • Handler MZ, Handler NS, Stephany MP et al (2016) Chikungunya fever: an emerging viral infection threatening North America and Europe. (springer.com)
  • Lebrun G, Chadda K, Reboux A-H et al (2009) Guillain-Barré syndrome after chikungunya infection. (springer.com)
  • Wielanek AC, Monredon JD, Amrani ME et al (2007) Guillain-Barré syndrome complicating a chikungunya virus infection. (springer.com)
  • During 2011-2013, a nationwide outbreak of chikungunya fever surveillance under the Philippine Integrated Disease virus infection occurred in the Philippines. (cdc.gov)
  • The most common symptoms of Chikungunya virus infection are fever and joint pain. (cor.net)
  • During the first week of infection, Chikungunya virus can be found in the blood and passed from an infected person to a mosquito through mosquito bites. (cor.net)
  • Poor glycemic control in patients with diabetes who have Chikungunya infection has been reported. (medscape.com)
  • In 2017, Chang et al reported that, although about 25% of individuals with Chikungunya infection eventually develop persistent arthritis, follow-up testing revealed no detectable Chikungunya virus on synovial fluid analysis among 38 study participants. (medscape.com)
  • These two viruses also cause similar clinical presentations, especially in the initial stages of infection, with neither virus possessing any specific distinguishing clinical features. (hindawi.com)
  • Concurrent infection with both viruses, transmitted from either two different mosquitos or one dually infected mosquito, is possible [ 5 , 6 ]. (hindawi.com)
  • Barry Alto, an associate professor of entomology at the UF Institute of Food and Agricultural Sciences, led a team of UF/IFAS researchers that measured mosquito infection and transmission of the emergent strains of chikungunya -- Asian and Indian Ocean - in Aedes aegypti and Aedes albopictus mosquitoes. (newswise.com)
  • They were also interested in studying the mechanisms behind Zika virus infection and transmission in mosquitoes. (eurekalert.org)
  • Four, seven, 10 and 17 days after the mosquitoes fed on Zika-virus-infected blood the researchers tested them for Zika virus infection, assessed whether the virus had disseminated -- or spread to other tissues in the mosquito, and examined whether the virus made its way to the mosquito saliva, where it must be present to be transmitted. (eurekalert.org)
  • Chikungunya infection is notifiable in New Zealand as an arboviral disease. (health.govt.nz)
  • Chikungunya virus infection should be considered in patients with acute onset of fever and polyarthralgia, especially travellers who have recently returned from areas with known virus transmission. (health.govt.nz)
  • As Chikungunya infection may cause a rash that could be confused other diseases such as dengue and measles, these other diseases do need to be ruled out. (health.govt.nz)
  • If people develop arthritis as a result of infection with the virus, they are given anti-inflammatory drugs, he said. (livescience.com)
  • Since there is no vaccine to prevent chikungunya and no medicine to treat it, people who are traveling to these areas should be aware of this infection and take steps to avoid mosquito bites , such as wearing repellent and long-sleeves and pants if possible," Gérardin said. (livescience.com)
  • Among the adults who were infected with the virus and developed encephalitis as a result of the infection, the disabilities included dementia and epilepsy, according to the study, published today (Nov. 25) in the journal Neurology. (livescience.com)
  • Chikungunya virus infection is common in Thailand, and routine use of diagnostic assays is needed. (thefreelibrary.com)
  • Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus. (medindia.net)
  • We report eight recent cases of Chikungunya virus infection in travellers to Australia. (mja.com.au)
  • C hikungunya virus is a mosquito-borne alphavirus infection first described in Tanzania in 1952. (mja.com.au)
  • We report eight cases of Chikungunya virus infection in travellers to Australia between February 2006 and September 2007. (mja.com.au)
  • The eight cases of Chikungunya virus infection were identified after reviewing the database of the Victorian Infectious Diseases Reference Laboratory between February 2006 and September 2007. (mja.com.au)
  • The review was undertaken to raise awareness among medical practitioners of Chikungunya virus infection. (mja.com.au)
  • The first patient diagnosed with Chikungunya virus infection was a 59-year-old Mauritian man who presented to hospital 5 days after travelling from Mauritius for the 2006 Commonwealth Games. (mja.com.au)
  • These eight patients illustrate the typical clinical presentation of Chikungunya virus infection. (mja.com.au)
  • Chikungunya virus infection is believed to confer lifelong immunity. (mja.com.au)
  • The viraemic phase of alphaviruses is 2-8 days, so the success of RT-PCR to detect the virus depends on early presentation and the clinical suspicion of a possible alphavirus infection. (mja.com.au)
  • Is the Subject Area "Chikungunya infection" applicable to this article? (plos.org)
  • In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. (plos.org)
  • It also illustrates how the analysis of clinical and biological data from human cohorts and the development of animal and cellular models of infection has helped to identify the tissue and cell tropisms of the virus and to decipher host responses in benign, severe or persistent disease. (archives-ouvertes.fr)
  • Given chikungunya's inevitable crossover to America, here's what you need to know about the virus - and how you can protect yourself from infection. (foxnews.com)
  • Chikungunya is a viral infection transmitted to humans by infected mosquitos - mainly by the Aedes aegypti and Aedes albopictus species. (foxnews.com)
  • Infection of the chikungunya virus occurs when a person gets bitten by a mosquito that has previously fed on another infected individual. (foxnews.com)
  • The virus, first identified in Tanzania in 1953, causes severe rashes and joint pains, but is rarely fatal, and the infection was considered benign. (virology.ws)
  • Since its discovery over 50 years ago, infection by chikungunya virus was known to be spread by mosquitoes, primarily Aedes aegypti , which feeds almost exclusively on humans. (virology.ws)
  • Since the first documented autochthonous transmission of chikungunya virus in the Caribbean island of Saint Martin in 2013, the infection has been reported within the Caribbean region as well as North, Central and South America. (eurosurveillance.org)
  • As of Dec. 10, the WHO states that "two confirmed, four probable, and twenty suspected cases of chikungunya infection have been reported. (medicaldaily.com)
  • In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean… There is no vaccine to prevent or medicine to treat chikungunya virus infection. (cogwriter.com)
  • A particular cause for concern for the people affected is an increase in the number of cases of brain malformations in newborns (microcephaly), for which a link with Zika virus infection has meanwhile been confirmed. (infectioncontroltoday.com)
  • Symptoms of Zika virus infection include rashes, headaches, joint and muscle pain, conjunctivitis and sometimes fever. (infectioncontroltoday.com)
  • A new method for permanently marking cells infected with chikungunya virus could reveal how the virus continues to cause joint pain for months to years after the initial infection, according to a study published August 29 in the open-access journal PLOS Pathogens by Deborah Lenschow of Washington University School of Medicine in St. Louis, and colleagues. (brightsurf.com)
  • Approximately 30 to 60 percent of people infected with the virus continue to experience joint pain for months to years after the initial infection. (brightsurf.com)
  • Using this system, they show in mice that marked cells surviving chikungunya virus infection are a mixture of muscle and skin cells that are present for at least 112 days after initial virus inoculation. (brightsurf.com)
  • Treatment of mice with an antibody that blocks chikungunya virus infection reduces the number of marked cells in the muscle and skin. (brightsurf.com)
  • Taken together, the findings provide further evidence for musculoskeletal cells as targets of chikungunya virus infection in the acute and chronic stages of disease. (brightsurf.com)
  • 2019) Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA. (brightsurf.com)
  • The cycle of infection is: a mosquito bites a person (or certain animals) that has the virus. (patriotledger.com)
  • Although after someone is infected with chikungunya, they seem to develop lifelong immunity (so they cannot get infected a second time), at this time there is no vaccination to prevent a first infection. (patriotledger.com)
  • Chikungunya, a viral infection transmitted to humans by infected mosquitoes, originated in southeast Africa and was first described in Tanzania in 1952. (pestworld.org)
  • Typical symptoms of Chikungunya infection include the rapid onset of severe joint pains (especially in the hands and feet) and fever. (pestworld.org)
  • Since a vaccine to prevent Chikungunya does not exist, it is best to try and avoid infection in the first place. (pestworld.org)
  • The current Indian Ocean epidemic and Italian outbreak have featured prominently on Internet infectious disease bulletins, and Chikungunya virus infection had been anticipated in travellers from the outbreak areas. (edu.au)
  • Chikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its Aedes vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. (mdpi.com)
  • BCW's Real-Time Reverse Transcription Polymerase Chain Reaction (RT-PCR) test detects cases in the acute stage of the Chikungunya infection, with results about five hours after the sample has been received. (infectioncontroltoday.com)
  • This test will help doctors and health authorities to quickly differentiate Chikungunya infection from other mosquito borne viruses that share the same health symptoms," says Sixto Pacheco, president and CEO of BCW. (infectioncontroltoday.com)
  • Is Chikungunya Infection Dangerous? (ms.gov)
  • The Mississippi State Department of Health has confirmed a number of cases of chikungunya virus infection in Mississippi residents recently returned from Haiti and the Dominican Republic. (ms.gov)
  • If you are sick with the symptoms of chikungunya, or you have been diagnosed with chikungunya infection, you can spread the disease to others through mosquito bites. (ms.gov)
  • Do not use this information to diagnose or ayurvedic treatment of allergy-immunity-infection-fever and/or chikungunya without consulting the doctor. (dabur.com)
  • While we have products /ayurvedic medicines for allergy-immunity-infection-fever and/or chikungunya, you must consult an authorized physician before taking any of the products. (dabur.com)
  • In a first step, a group of researchers including Thomas F. Meyer (Max Planck Institute for Infection Biology) identifed the proteins which the virus absolutely requires for replication in infected human host cells, by using a genome-wide screening. (uni-muenchen.de)
  • After an outbreak of Chikungunya infection in Emilia-Romagna Region (North-eastern Italy), a survey was performed to estimate the seroprevalence of antibody to Chikungunya virus and the proportion of asymptomatic infections, to identify factors associated with infection, and evaluate the performance of the surveillance system. (ajtmh.org)
  • This study provides basic parameters for modeling the transmission potential of outbreaks and planning control measures for Chikungunya infection in temperate settings. (ajtmh.org)
  • We feel we have now identified a fundamental mechanism which the chikungunya virus uses during infection that determines how dangerous the chikungunya infection will be," says study leader Anthony K. L. Leung, PhD, an assistant professor in the Department of Biochemistry and Molecular Biology at the Bloomberg School. (jhsph.edu)
  • The results of these studies open a whole new area of investigation into how cells control virus infection and how viruses that cause severe disease can circumvent that control," says Diane E. Griffin, a professor in W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Bloomberg School. (jhsph.edu)
  • For the research, Leung, Griffin and their colleagues, using neuronal cells and mouse models, uncovered a fundamental mechanism that determines how dangerous the chikungunya infection will be. (jhsph.edu)
  • Without this ability, the virus did not replicate and could not cause an infection. (jhsph.edu)
  • This shows us that the virus must break the bond between protein and ADP-ribose to cause infection - which gives us a road map for how to keep infected cells intact and healthy," Leung says. (jhsph.edu)
  • Symptoms of virus infection are usually mild, including fever, rash, headache and pain and swelling in the joints. (southeastagnet.com)
  • They later tested mosquitoes several days apart to determine how mosquito species and geographic origin may influence infection and how well the mosquitoes may be able to transmit the virus by biting a person. (southeastagnet.com)
  • Cases of Chikungunya infection in the US are believed to be transmitted from the Yellow Fever Mosquito, Aedes aegypti, which is common in warmer states like Texas, Louisiana, Mississippi, Alabama, Georgia, and Florida. (trulynolen.com)
  • Telltale symptoms of chikungunya infection are fever and joint pain that last about a week. (wustl.edu)
  • Further, by creating decoy handles, the researchers showed that they could reduce chikungunya infection and signs of arthritis. (wustl.edu)
  • We now know how chikungunya gets into cells, and we may have found a way to block the infection. (wustl.edu)
  • If the virus cannot get into the cell, it is unable to replicate and cause infection and disease. (wustl.edu)
  • Since chikungunya uses Mxra8 protein as a handle to open a door into cells, the researchers tested whether preventing the virus from grabbing that handle could reduce infection. (wustl.edu)
  • Only the few individual viruses that lucked onto a true handle could infect cells, so the overall infection rate - and signs of arthritis - would fall. (wustl.edu)
  • A day after infection, the level of virus in the mice's ankles and calf muscles was between tenfold and a hundredfold lower in the animals that had been treated with Mxra8 proteins or blocking antibodies than those that received placebo, and the numbers remained lower over the next two days. (wustl.edu)
  • 8 Although it is not demonstrated that cross-protection after infection with other alphaviruses (Ross River-RRV, O'nyong nyong-ONNV viruses) occurs in humans, it has been shown in animal models. (worldaidsday.org.au)
  • Chikungunya is a virus passed to humans by the bite of infected mosquitoes. (medlineplus.gov)
  • This means that mosquitoes in those areas have the virus and are spreading it to humans. (medlineplus.gov)
  • Mosquitoes spread the virus to humans. (medlineplus.gov)
  • Mosquitoes pick up the virus when they feed on infected people. (medlineplus.gov)
  • The mosquitoes that spread chikungunya are the same type that spread dengue fever , which has similar symptoms. (medlineplus.gov)
  • The best way to avoid getting the virus is to avoid getting bitten by mosquitoes. (medlineplus.gov)
  • If you get chikungunya, try to avoid getting bitten by mosquitoes so you do not pass the virus to others. (medlineplus.gov)
  • The virus is transmitted by mosquitoes and belongs to the family Togaviridae in the genus Alphavirus . (medicinenet.com)
  • Humans are infected when Aedes aegypti and albopictus mosquitoes, containing Chikungunya virus, bite humans. (medicinenet.com)
  • The viruses then multiply in humans and can then be picked up by other uninfected mosquitoes when they bite infected humans to complete the viral replication cycle. (medicinenet.com)
  • However, outbreaks can occur in populations where a number of both mosquitoes and humans are infected with the virus. (medicinenet.com)
  • Poor people are most at risk because they have less protection from mosquitoes, warns Peter Hotez of Baylor College of Medicine in Houston, Texas, but they are unlikely to be diagnosed with an exotic foreign virus - especially since most doctors do not have a specific test for the virus. (newscientist.com)
  • The virus can spread into a new area if an infected person arrives and is then bitten by Aedes mosquitoes. (newscientist.com)
  • West Nile virus invaded in 1999 and is now endemic, and tiger mosquitoes recently gave dengue fever to a man in Long Island, New York , the first ever case in the state. (newscientist.com)
  • The virus, which is transmitted from mosquitoes to humans and vice versa, has been spreading rapidly through the Caribbean since it was first identified on the island of St. Martin in. (wsj.com)
  • There's a concern that people from the United States who go to the Caribbean might be bitten by infected mosquitoes and then bring this illness, this virus, back to the United States,' Dr. Schaffner said. (newsmax.com)
  • In the past decade, chikungunya--a virus transmitted by Aedes spp mosquitoes--has re-emerged in Africa, southern and southeastern Asia, and the Indian Ocean Islands as the cause of large outbreaks of human disease. (nih.gov)
  • Chikungunya (pronunciation: chik-en-gun-ye) virus is transmitted to people by mosquitoes. (cor.net)
  • The virus is spread by bites from infected Aedes mosquitoes. (cor.net)
  • Chikungunya virus is spread by mosquitoes. (scidev.net)
  • Both cases involved persons infected with the virus following visits to the Caribbean, then both were bitten by uninfected mosquitoes in Florida, which then transmitted the virus further. (rt.com)
  • Can Florida Mosquitoes Transmit New Strains of Painful Chikungunya Virus? (newswise.com)
  • Researchers want to evaluate the ability of Florida mosquitoes to transmit chikungunya because the virus was transmitted in Florida as part of an outbreak throughout the Americas in 2014. (newswise.com)
  • Researchers led by Jorge Osorio, a UW-Madison professor of pathobiological sciences, and Scott O'Neill of the the Eliminate Dengue Program (EDP) and Monash University in Melbourne, Australia, are already releasing mosquitoes harboring the Wolbachia bacterium in pilot studies in Colombia, Brazil, Australia, Vietnam and Indonesia to help control the spread of dengue virus. (eurekalert.org)
  • While not typically found in the Aedes aegypti mosquito -- the species that also transmits dengue, chikungunya and yellow fever viruses -- O'Neill discovered in the early 1990s that Wolbachia could be introduced to the mosquito in the lab and would prevent the mosquitoes from transmitting dengue virus. (eurekalert.org)
  • In the study, the team infected mice with Zika virus originally isolated from a human patient and allowed mosquitoes from Medellin to feed on the mice either two or three days after they were infected. (eurekalert.org)
  • The mosquitoes were either harboring the same strain of the Wolbachia bacteria (called wMel) used in field studies or were Wolbachia -free and the mice had levels of virus in their blood similar to humans infected with Zika virus. (eurekalert.org)
  • An additional group of mosquitoes, both wild-type and Wolbachia -infected, was allowed to feed instead from a membrane containing sheep's blood spiked with a high concentration of Zika virus, per other standard laboratory studies. (eurekalert.org)
  • Chikungunya is a febrile viral illness transmitted by mosquitoes. (health.govt.nz)
  • The mosquitoes that are able to transmit Chikungunya virus are not normally found in New Zealand, therefore Chikungunya should only be considered in people who have recently travelled overseas. (health.govt.nz)
  • The mosquitoes that are able to spread Chikungunya virus are not normally found in New Zealand. (health.govt.nz)
  • Chikungunya virus is transmitted to people by mosquitoes. (livescience.com)
  • This virus is not spread person to person, but rather by the bite of certain mosquitoes. (tbo.com)
  • The cases of the virus, transmitted to humans through mosquitoes, have also been confirmed in North Carolina, Nebraska and Indiana. (rt.com)
  • Native mosquitoes also can carry the viruses. (baltimoresun.com)
  • A virus by the name of chikungunya, which is carried by mosquitoes, has spread to the Americas, appearing in the Carribean, the WHO states. (medicaldaily.com)
  • The virus, which is transmitted by mosquitoes, causes a rare form of viral fever. (sciencephoto.com)
  • However, the virus is now widespread in the Caribbean and it's likely only a matter of time before it is found in mosquitoes in the United States, possibly as early as this summer, according to the CDC. (cogwriter.com)
  • So there is transmission of the virus between people and mosquitoes going on right now in both those locations," she said. (cogwriter.com)
  • Aedes mosquitoes transmit chikungunya virus to people. (cogwriter.com)
  • Zika viruses are usually transmitted by Aedes mosquitoes, but can also be trans-mitted sexually. (infectioncontroltoday.com)
  • Chikungunya viruses are also transmitted by Aedes mosquitoes and cause symptoms similar to Zika virus infections. (infectioncontroltoday.com)
  • Chikungunya virus is spread by mosquitoes and causes severe joint and muscle pain. (brightsurf.com)
  • Chikungunya (which means "stooped walk" in a Tanzanian language, named because the joint pain from it makes people walk in a bent over fashion) is a viral illness transmitted by infected mosquitoes (only certain types of mosquitoes can carry this virus). (patriotledger.com)
  • although I am unaware of any cases transmitted from infected mosquitoes within the U.S., the types of mosquitoes that can carry this virus do exist here, so it is likely just a matter of time until there are cases of chikungunya acquired within the U.S. borders. (patriotledger.com)
  • however, other diseases, such as dengue fever, may have similar symptoms (and indeed dengue fever may be transmitted by the same types of mosquitoes and in the same geographic areas as chikungunya), so definitive diagnosis may be challenging. (patriotledger.com)
  • Finally, patients who are diagnosed with Chikungunya should avoid additional exposure to mosquitoes to help prevent the further spread of the virus to other mosquitoes and subsequently to other people. (pestworld.org)
  • The virus is spread through a variety of mosquitoes called Aedes Aegypti and Aedes Albopictus, said Weber-Morgan Health Department public relations director Lori Buttars. (revolutionradio.org)
  • Unlike West Nile virus, these mosquitoes are daytime biters. (revolutionradio.org)
  • Mosquitoes that carry chikungunya virus are mainly active in the daytime, but mosquitoes that are active toward dawn and dusk can carry other diseases, such as West Nile virus. (ms.gov)
  • The virus is transmitted to people by mosquitoes, with the most common symptoms being fever and joint pain, and other symptoms including headache, muscle pain, joint swelling, or rash. (revolutionradio.org)
  • The Centre said there was a risk the virus could spread in Europe if infected patients were bitten by mosquitoes upon their return home and those mosquitoes then infected other people. (repeatingislands.com)
  • Chikungunya is an RNA viral disease, transmitted to humans by infected Aedes aegypti or Aedes albopictus mosquitoes. (aimsciences.org)
  • A global sensitivity analysis using the reproduction number indicates that the mosquito biting rate, the transmission probability per contact of mosquitoes and of humans, mosquito recruitment rate and the death rate of the mosquitoes are the parameters with the most influence on Chikungunya transmission dynamics. (aimsciences.org)
  • Furthermore, the disease is spread by the same mosquitoes that transmit the dengue and Zika viruses. (jhsph.edu)
  • Chikungunya: the specific interactions between the genotypes of mosquitoes and viruses have influenced Ae. (pasteur.fr)
  • Thus, the specific interactions between the genotypes of mosquitoes and viruses have influenced Ae. (pasteur.fr)
  • Yellow fever and Asian tiger mosquitoes from Florida and Brazil can transmit an Asian strain of chikungunya virus that's emerging in North, South and Central America, a University of Florida scientist says. (southeastagnet.com)
  • In the study, researchers from Oswaldo Cruz Institute in Rio de Janeiro and UF/IFAS compared the abilities of yellow fever and Asian tiger mosquitoes from Brazil and Florida to transmit an emergent Asian strain of chikungunya virus present in North, South and Central America, Alto said. (southeastagnet.com)
  • Scientists conducted a laboratory experiment that let groups of mosquitoes eat chikungunya virus- infected blood. (southeastagnet.com)
  • However, mosquitoes are known to carry and transmit various viruses such as the deadly West Nile Virus, which has claimed the lives of 66 people since it was first discovered in the United States. (trulynolen.com)
  • With the aid of a warming planet and modern means of transportation, mosquitoes that carry chikungunya and related viruses are spreading. (wustl.edu)
  • A substantial proportion of mosquitoes became saliva-positive for both viruses (12%), suggesting that Ae. (wur.nl)
  • The virus was originally observed in Central and East Africa, circulating in a sylvatic cycle between forest-dwelling mosquitoes, non-human primates, 4,7 with sporadic human cases. (worldaidsday.org.au)
  • Phylogenetic relationships among chikungunya virus isolates from cases of chikungunya fever in France, based on complete E2-6K-E1 nucleotide sequence (2,771 nt) analysis. (nih.gov)
  • Other famous examples include the West Nile virus and dengue fever. (businessinsider.com)
  • Chikungunya causes a rash, fever, and excruciating joint pain that last from five to seven days. (webpronews.com)
  • Take pain relievers and fever reducers and just let the virus run its course, because there is no cure. (webpronews.com)
  • The chikungunya virus - or 'chik-v' - causes high fever and severe pain, and there is no vaccine to prevent it, CBS News reports. (newsmax.com)
  • The chikungunya fever will last for three, four, five days. (newsmax.com)
  • The chikungunya virus causes fever and debilitating joint pain, and until recently was found only in Africa and Southeast Asia. (livescience.com)
  • People infected with chikungunya virus experience fever and joint pain, and may develop muscle aches, headaches, joint swelling or rashes. (livescience.com)
  • GBS is a rare neurological complication which may occur after subsidence of fever and constitutional symptoms by several neurotropic viruses. (springer.com)
  • Tilak R, Ray S, Tilak VW, Mukherji S (2016) Dengue, chikungunya and the missing entity-Zika fever: a new emerging threat. (springer.com)
  • tients suspected to have chikungunya fever manifesting with symptoms such as fever, rash, and arthralgia. (cdc.gov)
  • Previous studies persons suspected to have chikungunya within 5 days after of chikungunya fever in the Philippines focused on clini- symptom onset. (cdc.gov)
  • Chikungunya, a virus more commonly found in Africa and Asia and transmitted by the aedes aegypti mosquito that causes dengue fever, was first detected in the eastern Caribbean at the start of 2014. (foxnews.com)
  • However, it remains unclear with residences served by unpaved streets, a presump- whether the attack rates in outbreaks in large popu- tive clinical diagnosis of chikungunya, and recall of an epi- lation centers in the Americas created sufficiently sode of fever with arthralgia in 2015-2016. (cdc.gov)
  • No specific antiviral treatment is available for Chikungunya fever. (medscape.com)
  • It is important to exclude other serious infections similar to Chikungunya fever such as dengue, malaria, or bacterial infections. (medscape.com)
  • People with suspected Chikungunya fever should avoid mosquito exposure during the first week of viremia to prevent local transmission of the illness. (medscape.com)
  • Chikungunya fever is an emerging global disease with several intriguing and unanswered questions such as the reason for sudden major rapid outbreaks with disease-free intervals, mode of survival or maintenance of the virus in nature between epidemics, factors that trigger the outbreaks, and strain replacements during outbreaks. (medscape.com)
  • Update: chikungunya fever diagnosed among international travelers--United States, 2006. (medscape.com)
  • Chikungunya fever in the United States: a fifteen year review of cases. (medscape.com)
  • The virus results in high fever for up to five days and a longer period of severe joint pain in the extremities that renders patients largely immobile. (rt.com)
  • The virus causes chikungunya fever - a painful condition whose symptoms include joint pain and swelling, headache, muscle pain or rash and in some instances, chronic rheumatoid arthritis that last for months to years. (newswise.com)
  • Between 2014 and 2016, more than 3,800 imported human cases of chikungunya fever in Florida highlighted the risk of contracting the illness, according to the new UF/IFAS study. (newswise.com)
  • CDC officials believe Chikungunya will behave like dengue fever, which has seen sporadic cases but not widespread outbreaks. (longislandpress.com)
  • Catching the mosquito-borne virus chikungunya usually leads to fever and severe pain, but a new study shows it may also lead to inflammation in the brain, and even death in some people. (livescience.com)
  • People who catch the virus are typically treated with fever-reducing medications and painkillers, Gérardin told Live Science. (livescience.com)
  • The most common signs of the virus are fever and joint pain, typically in multiple different joints. (foxnews.com)
  • That is raising concern over the possible spread of the virus, which is not usually fatal but can cause fever and debilitating joint pain and cannot be treated. (baltimoresun.com)
  • Experts with the federal Centers for Disease Control and Prevention said they believe chikungunya will behave similarly to dengue fever in the United States, with cases imported from other parts of the world causing sporadic local transmission but no major outbreaks. (baltimoresun.com)
  • Most people who contract West Nile virus, meanwhile, do not develop symptoms, but those who do typically develop a combination of fever, headache, body aches, skin rash and swollen lymph glands. (baltimoresun.com)
  • Symptoms of chikungunya - fever, nausea and severe pain, mainly in the joints - can persist for months, according to the WHO, Pravada.Ru notes (2/28). (kff.org)
  • Cummulative Number of Reported Cases of Chikungunya Fever in the Americas, by Country or Territory 2014. (eurosurveillance.org)
  • Although chikungunya fever is rarely fatal, patients can experience debilitating symptoms that last from months to years. (eurosurveillance.org)
  • Because there is no specific antiviral drug treatment for Chikungunya, physicians direct patients to use over the counter analgesics and medication to control fever, and to get plenty of rest and fluids. (pestworld.org)
  • Like many other arboviral diseases, chikungunya fever (CHIKF) is transmitted by mosquito vectors, primarily Aedes aegypti and Aedes albopictus [ 3 ]. (mdpi.com)
  • Chikungunya (CHIK) fever is a re-emerging Aedes mosquito-transmitted viral disease caused by CHIK virus belonging to the Togaviridae family of genus Alphavirus. (infectioncontroltoday.com)
  • There is currently no vaccine or medication to prevent chikungunya fever. (revolutionradio.org)
  • Chikungunya virus causes fever, muscle and joint pain, and swelling of the joints. (ms.gov)
  • If you develop symptoms of fever and joint pain within 14 days of traveling from countries in the Caribbean or other countries with known local transmission of chikungunya virus, you should see your healthcare provider and mention your recent travel. (ms.gov)
  • Chikungunya produces symptoms similar to dengue , including high fever, joint pain and skin rash. (medicalxpress.com)
  • The Health Department in American Samoa says it has confirmed the acute rash outbreak as cases of Chikungunya, a virus similar to dengue fever. (revolutionradio.org)
  • There is currently no vaccine or treatment for the mosquito-born virus which resembles dengue fever and can cause fever, skin rash and joint pain. (repeatingislands.com)
  • The Dengue fever is spread due to the bite of an infected Aedes aegypti mosquito infected with Dengue virus. (dabur.com)
  • People can get the chikungunya virus if they're bitten by an infected yellow fever mosquito, also known as Aedes aegypti or the Asian tiger mosquito, known as Aedes albopictus , said Alto, a faculty member at the UF/IFAS Florida Medical Entomology Laboratory in Vero Beach, Florida. (southeastagnet.com)
  • Since 2015, both viruses circulate in the same geographical regions of the Americas and are predominantly transmitted by the Yellow Fever mosquito Ae. (wur.nl)
  • In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. (nih.gov)
  • Both dengue and the chikungunya virus are spread by the Aedes aegypti mosquito, and symptoms of both viruses appear similar, making detection of chikungunya more difficult. (businessinsider.com)
  • The virus is endemic to tropical regions, but the spread of Aedes albopictus into Europe and the Americas coupled with high viraemia in infected travellers returning from endemic areas increases the risk that this virus could establish itself in new endemic regions. (nih.gov)
  • A novel form of the virus that has been primarily transmitted by the Aedes aegypti mosquito has emerged. (thehindu.com)
  • The chikungunya virus circulating in parts of India as well as Sri Lanka and South-East Asia could gain the ability to spread more efficiently by combining mutations, becoming 'super-adapted' for transmission by the Asian tiger mosquito, Aedes albopictus , according to research published recently. (thehindu.com)
  • The virus has been primarily transmitted by the Aedes aegypti mosquito. (thehindu.com)
  • Both viruses are arthropod-borne viruses (arboviruses) sharing a common vector: mosquitos of the Aedes genus, specifically A. aegypti and A. albopictus [ 4 ]. (hindawi.com)
  • People can get sick from chikungunya after an infected mosquito of the species Aedes aegypti, seen here, or Aedes albopictus bites them. (newswise.com)
  • Researchers at the University of Wisconsin-Madison have confirmed that a benign bacterium called Wolbachia pipientis can completely block transmission of Zika virus in Aedes aegypti , the mosquito species responsible for passing the virus to humans. (eurekalert.org)
  • Zika virus belongs to the same family as dengue virus and Aliota and Osorio -- with co-authors Stephen Penaido at SVM and Ivan Dario Velez, at the Universidad de Antioquia in Medellin, Colombia -- asked whether Wolbachia -harboring Aedes aegypti may also be effective against Zika virus. (eurekalert.org)
  • Some time during 2005 a virus was selected with a single amino acid change in the envelope glycoprotein which allows efficient replication in Aedes albopictus, the predominant mosquito in Réunion. (virology.ws)
  • To further complicate matters, not only is Aedes albopictus now a good host for chikungunya virus, but the mosquito is spreading across the globe from eastern Asia to Europe and the United States. (virology.ws)
  • The risk of autochthonous transmission of chikungunya virus becoming established in Spain may be elevated due to the large numbers of travellers returning to Spain from countries affected by the 2013 epidemic in the Caribbean and South America, as well as the existence of the Aedes albopictus vector in certain parts of Spain. (eurosurveillance.org)
  • Here we comprehensively assess the global distribution of chikungunya and produce high-resolution maps, using an established modelling framework that combines a comprehensive occurrence database with bespoke environmental correlates, including up-to-date Aedes distribution maps. (eurosurveillance.org)
  • The mosquitos that carry the Chikungunya virus (aedes aegypti and aedes albopictus) can bite during the day and at night, both indoors and outdoors, and often live around buildings in urban areas. (pestworld.org)
  • The mosquito that transmits chikungunya-the Aedes aegypti-is the same one that spreads dengue. (medicalxpress.com)
  • Aedes vigilax, Aedes procax, Coquillettidia linealis, and Aedes notoscriptus [all competent RRV and Barmah Forest virus (BFV) vectors] as well as Aedes aegypti and Aedes albopictus . (worldaidsday.org.au)
  • However, ten years back, a novel form of the virus emerged in coastal Kenya, which then spread to countries around the Indian Ocean, including India, causing huge outbreaks. (thehindu.com)
  • Whereas mosquito-based surveillance is the preferred method for monitoring or predicting West Nile virus outbreaks, it is not the preferred method for monitoring or predicting Chikungunya outbreaks. (cor.net)
  • Newswise - GAINESVILLE, Fla. --- University of Florida scientists are starting to better understand the ability of two Florida mosquito species to transmit two strains of chikungunya virus that have caused outbreaks of human disease around the world. (newswise.com)
  • Outbreaks of chikungunya have occurred in many regions of the world, including Africa, Asia, and the Caribbean islands, the researchers said. (livescience.com)
  • Now that chikungunya is in the United States, CDC officials think it will behave like dengue virus, with imported cases causing occasional local transmissions but not widespread outbreaks. (tbo.com)
  • Millions of people have contracted Zika and chikungunya virus infections since the outbreaks that have been striking Latin America since 2013. (infectioncontroltoday.com)
  • It is thought that most people infected with chikungunya develop symptoms within two days to two weeks after the virus is transmitted from the bite of an infected mosquito, although some studies after outbreaks in Africa have shown that up to 50 percent of people who were infected, as demonstrated by antibodies to the virus in their blood tests, did not report any symptoms. (patriotledger.com)
  • During outbreaks of Chikungunya - or if mosquito populations surge - community-wide insect/vector control programs may be activated and travelers should heed these warnings. (pestworld.org)
  • Prior to 2013, chikungunya virus outbreaks had been identified in countries in Africa, Asia, Europe and the Indian and Pacific Oceans. (jhsph.edu)
  • Our findings suggest that mosquito-virus interactions of both these mosquito species may vary by geographic population - whether that's in Brazil or Florida - which may impact public health measures and should be considered during outbreaks of this mosquito-borne disease," said Honório. (southeastagnet.com)
  • We extracted virus (family Togaviridae , genus Alphavirus ). (cdc.gov)
  • Chikungunya virus was diagnosed by performing a generic alphavirus reverse transcriptase polymerase chain reaction (RT-PCR) on serum. (mja.com.au)
  • Blood taken at admission was positive for alphavirus RT-PCR, and sequencing confirmed Chikungunya virus. (mja.com.au)
  • The findings indicated that even more efficient chikungunya virus transmission by A. albopictus "will likely evolve when combinations of these second-step mutations occur in their current ranges of endemic circulation in India and Southeast Asia, followed by their likely global spread," the scientists noted in the paper. (thehindu.com)
  • Should a super-adapted strain arise, rising levels of immunity to chikungunya in regions where it is endemic might prevent an increase in disease incidence in the local population, said Dr. Weaver in an email. (thehindu.com)
  • Chikungunya has been endemic in parts of Africa for a long time. (patriotledger.com)
  • Rather, travelers are advised to take a number of precautions when staying in countries where Chikungunya is endemic. (pestworld.org)
  • The resulting virus fails to replicate in its mosquito vector, an important safety feature when immunizing travelers or laboratory personnel in non-endemic locations. (fiercebiotech.com)
  • The virus is endemic in Africa, India, South-East Asia and the Western Pacific and is considered to be emerging or re-emerging in many regions of the world. (worldaidsday.org.au)
  • As of December 2014, 41 countries or territories in the Caribbean, Central America, South America and North America have had laboratory-confirmed Chikungunya infections. (medicinenet.com)
  • How do health care professionals diagnose Chikungunya virus infections? (medicinenet.com)
  • The best way to prevent Chikungunya infections is to avoid getting mosquito bites. (rxlist.com)
  • Two new studies explore strategies that could offer relief from the debilitating joint pain caused by Chikungunya virus infections, an emerging disease with no known therapies. (eurekalert.org)
  • Lewthwaite P, Vasanthapuram R, Osborne JC et al (2009) Chikungunya virus and central nervous system infections in children, India. (springer.com)
  • Health officials in Florida also reported the first domestically acquired chikungunya infections in the United States. (rt.com)
  • News of the local residents' infections came last week shortly after the U.S. Centers for Disease Control and Prevention (CDC) confirmed the first case of Chikungunya to be contracted within the continental United States, in Florida. (longislandpress.com)
  • Given the conservation of viral macrodomains in all alphaviruses and coronaviruses, our study may guide the design of small molecule chemical compounds that block hydrolase activity for treatment of a range of virus infections. (pnas.org)
  • This virus is also widespread in Latin America and can cause symptoms similar to those of Zika infections but presumably does not cause malformations. (infectioncontroltoday.com)
  • Subsequently, infections can solely be confirmed by detecting the antibodies against the virus produced by the infected individual. (infectioncontroltoday.com)
  • However, vaccinations and infections with similar viruses hamper precise antibody detection. (infectioncontroltoday.com)
  • Patients with confirmed Zika or chikungunya virus infections were included in the study. (infectioncontroltoday.com)
  • In Zika virus infections, the virus concentration is already so low in the first week that particularly sensitive testing is required and combined antibody testing should be done. (infectioncontroltoday.com)
  • We can see very clearly that a combination of several testing procedures must be used to obtain precise Zika virus test results, particularly in tropical regions where people contract infections with many viruses that are related to each other,' Drexler concludes. (infectioncontroltoday.com)
  • Prompt diagnosis of Chikungunya virus infections is of public health significance as the mosquito vectors for transmission exist in Australia. (edu.au)
  • In 2004, an outbreak of chikungunya disease started in Kenya and spread to islands in the Indian Ocean and finally India, where it had not been reported for 32 years. (virology.ws)
  • Ledrans M, Quatresous I, Renault P, Pierre V. Outbreak of chikungunya in the French Territories, 2006: lessons learned. (eurosurveillance.org)
  • There has been a recent outbreak of Chikungunya, a mosquito-borne disease prevalent in India and Southeastern Asia. (trulynolen.com)
  • Corroborating these results further, Jonathan Miner and colleagues found that the rheumatoid arthritis drug Abatacept (which hinders T cell activation in the lymph nodes) decreased inflammation in the joints of infected mice, and abolished arthritis completely when given in combination with an antibody targeting the virus. (eurekalert.org)
  • Available diagnostic tests are aimed at detection of the virus, its antigenic components, or the host immune antibody response. (hindawi.com)
  • Transplacental chikungunya virus antibody kinetics, Thailand. (thefreelibrary.com)
  • Each Chikungunya virus Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Chikungunya Virus Monoclonal antibody specifically detects Chikungunya Virus in Virus samples. (fishersci.com)
  • The name chikungunya (pronounced "chik-en-gun-ye") is an African word meaning "bent over in pain. (medlineplus.gov)
  • Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic. (jcvi.org)
  • Puerto Rican health officials declared Thursday an epidemic of chikungunya, a mosquito-borne virus that has shown up in more than 200 confirmed cases across the island as of late last month. (rt.com)
  • In the study, researchers looked at an epidemic of the virus on Reunion Island, in the Indian Ocean near Madagascar, that lasted from 2005 to 2006 and sickened 300,000 people. (livescience.com)
  • As clinicians became aware of the Indian Ocean epidemic, unwell travellers returning from affected countries were tested for Chikungunya virus. (mja.com.au)
  • Our observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector. (nih.gov)
  • Chikungunya: Evolutionary history and recent epidemic spread. (eurosurveillance.org)
  • The virus: isolation, pathogenic properties and relationship to the epidemic. (eurosurveillance.org)
  • This information is essential to better estimate the risks of chikungunya emergence, specifying the strong genetic proximity of the mosquito in South-East France with that of La Reunion Island, where the largest chikungunya epidemic ever occurred in France, and more generally in Europe. (pasteur.fr)
  • Chikungunya is an epidemic disease in Brazil and a potential risk in Florida," Alto said. (southeastagnet.com)
  • Nearly 250 people have contracted the virus in Puerto Rico, where health officials have declared an epidemic. (travelagentcentral.com)
  • MIAMI-Public health officials in Florida said Thursday that two people in the state contracted the mosquito-borne chikungunya virus locally, the first confirmed cases in which the disease was acquired in the continental U.S. rather than overseas. (wsj.com)
  • Cases of the virus have turned up in New York, Florida, and other states, according to the CDC. (newsmax.com)
  • Scientists confirmed the first case of chikungunya in Florida in 2014. (newswise.com)
  • Transmission of chikungunya virus in the U.S. is a major public health concern," said Alto, a faculty member at the UF/IFAS Florida Medical Entomology Laboratory in Vero Beach, Florida. (newswise.com)
  • In 2014, a Florida man became the first person to become infected with the virus in the U.S. (previously, other people had been diagnosed with chikungunya in the U.S., but they had contracted the virus while traveling elsewhere). (livescience.com)
  • In both, they said, a person infected with the virus after visiting the Caribbean was then bitten again by an uninfected mosquito in Florida, which then transmitted the illness further. (tbo.com)
  • Florida has been the worst hit by the virus, with at least 25 cases reported in the state, according to the US Centers for Disease Control and Prevention. (rt.com)
  • The Florida Department of Health released a set of guidelines in order to avoid becoming infected and spreading the virus. (rt.com)
  • State health officials are urging Marylanders to be wary of mosquito-borne diseases like West Nile virus and, now, the dengue-like virus chikungunya - raising concerns after it was reported in a Florida man Thursday. (baltimoresun.com)
  • Just one week after health officials warned Florida inhabitants of the mosquito-borne virus chikungunya spreading through their state, several more states have reported cases of the disease. (medicaldaily.com)
  • So far, Florida has experienced 25 cases, but North Carolina, Nebraska, and Indiana have all confirmed several chikungunya cases this week. (medicaldaily.com)
  • The Asian strain of the virus is not currently circulating in Florida, and Barry Alto, associate professor of entomology at the UF Institute of Food and Agricultural Sciences, said that he can't predict whether it will cause local transmission in the Sunshine State this year. (southeastagnet.com)
  • That year, scientists confirmed the first case of chikungunya in Florida. (southeastagnet.com)
  • The mosquito-borne virus has spread through the Caribbean, and the first two cases in the United Stated were reported last week in Florida. (travelagentcentral.com)
  • Specifically, we identified multiple introductions in both Nicaragua and Florida, with rapid local spread of viruses in Nicaragua but limited autochthonous transmission in Florida in the US. (jcvi.org)
  • This Seminar focuses on the re-emergence of this disease, the clinical manifestations, pathogenesis of virus-induced arthralgia, diagnostic techniques, and various treatment modalities. (nih.gov)
  • Chikungunya virus pathogenesis: From bedside to bench. (archives-ouvertes.fr)
  • Chikungunya in Infants and Children: Is Pathogenesis Increasing? (mdpi.com)
  • There is a risk that the virus will be imported to new areas by infected travelers. (cdc.gov)
  • Travelers to those countries where Chikungunya is prevalent are advised to use mosquito repellent with DEET and to wear long sleeves and pants. (webpronews.com)
  • An average of 28 cases Chikungunya had been reported annually in the nation from 2006 to '13, mostly from travelers returning from Asia. (longislandpress.com)
  • But, the spike in Chikungunya-infected travelers entering the nation increases the chances of local transmission. (longislandpress.com)
  • More than 230 chikungunya cases have been reported in Americans this year, but all the others were travelers believed to have been infected elsewhere. (tbo.com)
  • They involve travelers who returned from the Dominican Republic on May 17 and May 29, said state officials, adding that authorities are currently investigating several other suspicious cases of the virus. (rt.com)
  • Given the amount of U.S. travelers who vacation on these tropical islands each year, health experts believe chikungunya will soon spread beyond the Caribbean Sea, setting up shop in its neighboring continents. (foxnews.com)
  • Cases of chikungunya have been reported in travelers returning to the US, although transmission within the country has not been reported. (virology.ws)
  • Chikungunya virus is a mosquito-borne disease especially prevalent in the Caribbean, where it can infect U.S. travelers. (ms.gov)
  • Chikungunya can spread from person to person through the bite of a mosquito once travelers return home. (ms.gov)
  • U.S. travelers contracted the virus in tropical destinations including Anguilla , the Dominican Republic , Guyana, Haiti , Indonesia, Tonga and the U.S. Virgin Islands , according to the Centers for Disease Control and Prevention. (travelagentcentral.com)
  • The ease with which people travel will make it difficult to break the continuing transmission of chikungunya, warns Hervé Zeller, head of emerging diseases at ECDC. (newscientist.com)
  • Chikungunya virus is a mosquito-borne illness that has rapidly spread throughout the Americas, with more than 1.7 million suspected cases since the first incidence of local transmission was detected in the Caribbean in 2013. (eurekalert.org)
  • Samples were collected from pa- the transmission pattern of this virus in the Philippines. (cdc.gov)
  • Alto views the new findings as useful measurements that can be used in risk assessment by scientists as they model chikungunya transmission. (newswise.com)
  • But it all changed in 2013, when health experts found that sustained transmission of the chikungunya virus had occurred in the Caribbean, meaning people on the islands were starting to become infected by local mosquitos. (foxnews.com)
  • The Pan-American Health Organization (PAHO), a regional arm of the World Health Organization (WHO), on Tuesday "unveiled new guidelines to help countries throughout the Americas detect and prevent transmission of the mosquito-borne chikungunya virus - a disease which has already infected more than two million people around the world," the U.N. News Centre reports. (kff.org)
  • This has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area. (nih.gov)
  • This is the first time that locally acquired transmission of chikungunya has been detected in the WHO Americas Region," the WHO said in a statement . (medicaldaily.com)
  • Coloured transmission electron micrograph (TEM) of chikungunya virus particles (yellow). (sciencephoto.com)
  • In this paper, an age-structured deterministic model for the transmission dynamics of Chikungunya virus is presented. (aimsciences.org)
  • We have the kind of mosquito that will transmit this virus here in the U.S. (newsmax.com)
  • In a newly published study led by Brazilian scientist Nildimar Honório of the Oswaldo Cruz Institute, Alto helped assess the ability of the two mosquito species to transmit chikungunya. (southeastagnet.com)
  • Chikungunya disease is characterized by polyarthralgia, sometimes associated with rash. (plos.org)
  • Like any viral syndrome, chikungunya can also cause muscle aches, headaches, rash and joint swelling. (foxnews.com)
  • In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. (cdc.gov)
  • Although Chikungunya virus has been mainly reported in Africa, Asia, Europe, and the islands in the Indian and Pacific oceans, it has spread to the Americas recently. (medicinenet.com)
  • It is the first time the mosquito-borne virus is known to have spread in the Americas. (newscientist.com)
  • In the Americas, only Brazil, Canada, the US and the French territories of French Guiana, Guadeloupe and Martinique have the capability to test for the virus, says Donna Eberwine-Villagrán of PAHO. (newscientist.com)
  • But "controlling the spread of [insect-borne] viruses in the Americas has not been very successful," admits PAHO in its chikungunya response report. (newscientist.com)
  • The U.S. Defense Advanced Research Projects Agency, or DARPA, is challenging innovators to build models to predict how the mosquito-borne chikungunya virus could spread across countries in the Americas. (livescience.com)
  • But since last year, the virus has spread to the Americas, and has infected thousands of people in the Caribbean. (livescience.com)
  • There is no commercial vaccine for the virus, which was detected for the first time in the Americas late last year. (foxnews.com)
  • Chikungunya has been identified in nearly 40 countries in Asia, Africa, Europe and the Americas. (health.govt.nz)
  • The arrival of chikungunya virus, first in the tropical Americas and now in the United States, underscores the risks posed by this and other exotic pathogens," said Roger Nasci, of the Centers for Disease Control and Prevention, in a prepared statement. (tbo.com)
  • According to WHO, Chikungunya was first described during an outbreak in southern Tanzania in 1952, eastern Africa, and since then has been detected in nearly 40 countries in Asia, Africa, Europe and also in the Americas. (rt.com)
  • The guidelines' authors, PAHO adviser on viral diseases Otavio Oliva and PAHO adviser on dengue Jose Luis San Martin, warned that the fact that people in the Americas have not been exposed to chikungunya virus, placed the region at particular risk for the introduction and spread of the virus," the news service adds (2/28). (kff.org)
  • But since 2013, chikungunya, which is debilitating but rarely fatal, has been detected throughout the Americas, with more than 1.7 million suspected cases in this region alone. (jhsph.edu)
  • Chikungunya is a virus of the Togaviridae family which has affected different parts of the world on several occasions: 2004 in the Indian Ocean, 2007 in Africa, 2007 in Europe, 2011 in the Pacific region, and 2013 in the Americas. (pasteur.fr)
  • Our findings high levels of herd immunity to preclude subsequent indicate that the chikungunya outbreak in Salvador may epidemics. (cdc.gov)
  • This concern was further solidified by the recent incursion of the virus into the Western hemisphere, a region without pre-existing immunity. (mdpi.com)
  • The virus is rarely fatal, according to health officials. (rt.com)
  • The rarely fatal virus causes symptoms such as severe fevers, arthritic-like joint paint, muscle pain, headaches, joint swelling and rashes. (longislandpress.com)
  • Chikungunya virus is rarely fatal. (tbo.com)
  • Chikungunya is rarely fatal and typically spread to humans through mosquito bites. (medicaldaily.com)
  • Although Chikungunya is rarely fatal, symptoms of the illness include high fevers in excess of 102 °F, severe headaches, nausea, vomiting, conjunctivitis, and severe joint pain that typically lasting for about two weeks. (trulynolen.com)
  • This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation. (plos.org)
  • Chikungunya disease is characterized by acute transient febrile arthralgic illness, but can also lead to chronic incapacitating arthralgia. (plos.org)
  • The mutation, known as 'E2-L210Q,' further enhanced the virus' ability to replicate in the A. albopictus mosquito and thereby increase its circulation among humans. (thehindu.com)
  • Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. (asm.org)
  • The virus is spread to humans through mosquito bites, and it causes symptoms of splitting headaches, high fevers, and aching joints. (medicaldaily.com)
  • Mexico has detected its first domestic case of the painful mosquito-borne viral disease chikungunya in the southwest of the country, the state government of Chiapas said on Saturday. (foxnews.com)
  • Using this approach, a group from the UMR_D 190, Emerging viruses Department in Marseille, France in collaboration with the University of Sydney, Australia, showed that the engineered viruses exhibit a stable phenotype with a significantly decreased viral fitness (i.e., replication capacity), making it a new vaccine candidate for the emerging viral disease. (medindia.net)
  • Health Minister Violeta Menjivar said at least 1,200 people have been formally diagnosed with the chikungunya viral disease, although the positive testing must still be confirmed by the US Centers for Disease Control and Prevention. (medicalxpress.com)
  • The amino acid change enhances viral replication in the mosquito, leading to much higher levels of virus in the salivary gland. (virology.ws)
  • For this purpose, the researchers switched off each individual gene of the human cells in a complex automated process, infected the modified cells, and then analyzed the extent of virus replication. (uni-muenchen.de)
  • This enabled them to identify more than 100 human proteins that are essential for the replication of the virus. (uni-muenchen.de)
  • In cooperation with virologists including Marc Lecuit of the Institut Pasteur (Paris), as well as researchers from the Charité and the Steinbeis Innovation Center in Berlin, the Institute of Technology in Tartu, Estonia, and Bracher's research group at the Department of Pharmacy, the scientists identified the substances which can control these important human proteins and thus inhibit the replication of the virus. (uni-muenchen.de)
  • Another study published in the journal Emerging Infectious Diseases showed that the turmeric compound decreased viral replication by more than 90 percent in cultured cells infected with influenza-A. The compound was also found to inhibit the virus from infecting other cells. (naturalnews.com)
  • Another study by McMaster University researchers revealed that the turmeric compound stopped both simplex-1 and herpes simplex-2 viruses from spreading by preventing the replication of the viruses in infected T-cells. (naturalnews.com)
  • In 2013 the virus had spread to the Caribbean islands. (medicinenet.com)
  • A dozen people on the tiny Caribbean island of St Martin have been infected with the chikungunya virus. (newscientist.com)
  • The virus was first recorded in 1952 in Africa then Asia, but in 2013 it began to spread to the Caribbean and Haiti. (webpronews.com)
  • Most chikungunya patients in the United States were infected when traveling in the Caribbean, but four Americans have caught the virus inside this country . (livescience.com)
  • Chikungunya has already appeared in much of the Caribbean, Central America and the United States. (foxnews.com)
  • The virus was introduced into the Caribbean region late last year, according to AP. (rt.com)
  • As of July 11, the Pan American Health Organization recorded more than 354,000 suspected and confirmed cases of chikungunya across the Caribbean. (rt.com)
  • The chikungunya virus, a mosquito-borne illness that causes high fevers and sometimes intense pain, is spreading rapidly throughout the Caribbean. (foxnews.com)
  • Now the virus is widespread, with up to 17 different countries in the Caribbean reporting cases of the disease. (foxnews.com)
  • The virus spread quickly through the Caribbean, starting on the French side of the island of Saint Martin, and into South and Central America late last year. (baltimoresun.com)
  • Chikungunya outbreak in the Caribbean region, December 2013 to March 2014, and the significance for Europe. (eurosurveillance.org)
  • An African mosquito-bred virus by the name of "chikungunya" has been confirmed in two cases in the French part of the Caribbean isle of Saint Martin, located off the eastern coast of Puerto Rico, and situated between North and South America. (medicaldaily.com)
  • Chikungunya - which triggers a very painful but seldom fatal illness - is already common in central and southern Africa, southern Asia and has recently spread to 17 countries in the Caribbean, the CDC noted. (cogwriter.com)
  • More recently, Chikungunya has been reported in at least 15 Caribbean islands, including Hispaniola (Haiti & Santo Domingo), as well as French Guiana on mainland South America. (pestworld.org)
  • Chikungunya, once confined to Africa and Asia, is now prevalent in the Caribbean and bordering countries in South and Central America, including Haiti and the Honduras. (ms.gov)
  • Mississippians who travel to the Dominican Republic, Haiti, Puerto Rico or other Caribbean countries are at risk of chikungunya virus. (ms.gov)
  • Cases of chikungunya have occurred on the Caribbean island of Saint Martin, marking the first time the mosquito-borne disease has spread in the western hemisphere, the World Health Organisation (WHO) said on Tuesday. (medicalxpress.com)
  • A mosquito-borne virus that was detected for the first time in Haiti last week has quickly spread throughout the Caribbean nation, a health official said Tuesday. (medicalxpress.com)
  • A nasty mosquito-borne virus that has been spreading rapidly in the Caribbean has made its way to the U.S. Virgin Islands, authorities said Wednesday. (medicalxpress.com)
  • The number of suspected and confirmed cases of chikungunya virus in Caribbean countries has risen sharply over past weeks, health officials say. (repeatingislands.com)
  • According to Karen Weintraub ( National Geographic ) Chikungunya has plagued other parts of the world-particularly Asia and Africa-for decades, becoming more prevalent in recent years, but it arrived in the Caribbean only in December and has already infected as many as 250,000 people there. (repeatingislands.com)
  • Most of the chikungunya cases have occurred in the Caribbean islands, Africa, and East Asia, and now that they've arrived in the U.S., the CDC is concerned about an outbreak here. (medicaldaily.com)
  • So far this year we've recorded eight travel-associated cases, and seven of them have come from countries in the Caribbean, where we know the virus is being transmitted," Roger Nasci, chief of the CDC's Arboviral Disease Branch in the Division of Vector-Borne Diseases, told CNN . (medicaldaily.com)
  • The chikungunya virus , the mysterious mosquito-borne virus first discovered in the Caribbean on the sister islands of St. Maarten/St. Martin, is continuing to spread throughout the United States with recent news that 25 New Jersey residents have tested positive for the virus following a Caribbean vacation. (travelagentcentral.com)
  • On Wednesday, stltoday.com reported that a 38-year-old St. Louis County woman was infected with the mosquito-borne virus chikungunya while traveling in the Caribbean. (travelagentcentral.com)
  • Once limited to Asia and Africa, chikungunya virus has infected more than a million people in the Caribbean and South America in an outbreak that began in 2013 and continues to this day. (wustl.edu)
  • Chikungunya-pronounced chik-un-GUHN-ya -means "that which bends up" in Makonde, a language spoken in the African nation of Tanzania, where it was discovered in 1955. (longislandpress.com)
  • The name Chikungunya means "that which bends up" in the Makonde language of the Newala Province, Tanzania. (mja.com.au)
  • In fact, in the Makonde language, the term "chikungunya" means to be bent out of shape, in reference to the virus's ability to cause people to contort in pain. (foxnews.com)
  • The name "chikungunya" in the Makonde dialect refers to the stooped posture assumed by many patients who experience disabling joint pain [ 4 ]. (mdpi.com)
  • The name chikungunya comes from the Makonde language of Tanzania, and it means 'to walk bent over. (wustl.edu)
  • 5,6 ﻽ The name chikungunya is derived from the Makonde root verb, meaning "to become contorted" or "that which bends up" in reference to the stooped posture developed when arthritic symptoms appear. (worldaidsday.org.au)
  • For the most up-to-date information, please visit the Centers for Disease Control and Prevention's (CDC) website -- www.cdc.gov/chikungunya . (medlineplus.gov)
  • Chikungunya virus disease became a nationally notifiable condition in 2015. (cdc.gov)
  • A new mosquito-borne virus that has sickened tens of thousands of people throughout the Carribbean is now threatening the U.S., with cases confirmed in 15 states, the Centers for Disease Control and Prevention Reports. (newsmax.com)
  • This is an infographic describing the disease burden of Chikungunya virus. (eurekalert.org)
  • Infected patients are at-risk for long-term joint stiffness and pain, which increases the need to better understand the sequence diversity of these viruses and how any viral mutations affect the severity of disease in the human host. (jcvi.org)
  • This year, 571 cases of chikungunya virus disease have been reported so far in 42 U.S. states, including cases contracted both here and elsewhere. (livescience.com)
  • "It will be more difficult for the virus to establish itself here," Dr. William Schaffner, an infectious disease specialist at Vanderbilt University Medical Center in Nashville, Tennessee told Tech Times. (rt.com)
  • 1 Chikungunya is believed to be derived from an East African dialect describing the contorted posture of patients with the severe joint pain characteristic of this disease. (virology.ws)
  • Weaver SC , Lecuit M . Chikungunya virus and the global spread of a mosquito-borne disease. (eurosurveillance.org)
  • Chikungunya disease does not often result in death, but its symptoms can be severe and disabling, officials said. (cogwriter.com)
  • According to the Centers for Disease Control and Prevention (CDC), as of June 10, a total of 39 chikungunya cases have been reported from U.S. states and territories. (pestworld.org)
  • During the recent outbreak the virus was also found to cause long-term joint pain, severe neurological disease and even fatalities. (infectioncontroltoday.com)
  • According to the Center for Disease Control and Prevention (CDC), as of Dec. 16, 2014 a total of 2,021 Chikungunya virus disease cases have been reported in the United States. (infectioncontroltoday.com)
  • There is no vaccine or treatment for chikungunya , which has infected millions of people in Africa and Asia since the disease was first recorded in 1952. (medicalxpress.com)
  • The Centers for Disease Control and Prevention (CDC) will be monitoring the spread of the virus in various states this summer, specifically in Nevada, New York, California, Arkansas, Maryland, Connecticut, Minnesota, Virginia, Puerto Rico and the U.S. Virgin Islands. (medicaldaily.com)
  • Researchers led by the Johns Hopkins Bloomberg School of Public Health have identified a mechanism by which the chikungunya virus infects healthy cells and controls how severe the disease it causes will be, a mechanism they believe can be found in a number of other related viruses for which there are no treatments or licensed vaccines. (jhsph.edu)
  • This mechanism depends on a class of conserved protein domains -- called macrodomains -- that are found in several viruses that cause human disease, such as hepatitis E virus, rubella virus, all coronaviruses and all alphaviruses. (jhsph.edu)
  • Our study measuring the mosquito's ability to pass along the disease contributes to our understanding of the epidemiology of chikungunya. (southeastagnet.com)
  • According to the researchers, this effect proved especially beneficial - as exposure to the HCV virus caused severe liver disease and was known to affect more than 160 million people around the world. (naturalnews.com)
  • Although Chikungunya may be relatively new to the United States, the mosquito that transmits the disease is not. (trulynolen.com)
  • Blocking the virus from latching on to the handle could prevent or treat disease. (wustl.edu)
  • The findings, published May 16 in the journal Nature, could lead to ways to prevent or treat disease caused by chikungunya and related viruses. (wustl.edu)
  • The virus called chikungunya causes severe joint pain which can last for years. (rt.com)
  • Severe symptoms (even death) may rarely occur as a complication of chikungunya and may include breathing compromise, heart inflammation or failure, liver or kidney failure, eye inflammation/conditions and/or neurological symptoms. (patriotledger.com)
  • Chikungunya comes from an African word for "to become contorted," which describes the stooped appearance of infected individuals suffering from severe joint pain. (jhsph.edu)
  • According to a team of researchers from the Pasteur Institute in France, the turmeric compound not only inhibited the growth of zika and chikungunya viruses, but also halted the ability of these harmful viruses to infect otherwise healthy cells. (naturalnews.com)
  • This packet presents raster data files that accompany a manuscript submitted for publication to Philosophical Transactions of the Royal Society, titled "Climate Change Influences on Global Vector Distributions for Dengue and Chikungunya Viruses. (ku.edu)
  • The Mississippi State Department of Health is investigating its first potential case of chikungunya virus, a mosquito-borne illness traditionally found in Africa and Asia. (cogwriter.com)
  • Researchers from Japan and India have developed a rapid and effective test for chikungunya virus that will more suitable for use in developing countries than current diagnostic techniques. (scidev.net)
  • No laboratories in New Zealand currently test for Chikungunya virus. (health.govt.nz)
  • The Indian Ocean strain of chikungunya virus caused an outbreak in the Indian Ocean region with an estimated 1.5 million human cases from 2004 to 2006, Alto said. (newswise.com)
  • Strains of this virus found in islands off Africa, states in India such as Kerala, Sri Lanka and in countries in South-East Asia had a mutation that allowed it to be passed on by the A. albopictus mosquito as well. (thehindu.com)
  • A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. (archives-ouvertes.fr)
  • The findings reinforce the need for officials to be on the lookout for dengue and chikungunya cases, and to find ways to control its spread in India. (medindia.net)
  • The virus is not usually fatal, though, with 1 death in every 1,000 cases , and then usually only in the elderly or immune-compromised. (businessinsider.com)
  • Chikungunya is spread by two mosquito species, and is typically not fatal. (foxnews.com)
  • Chikungunya is generally not fatal, but the painful symptoms have led people to say "It won't kill you, but it may make you wish you were dead! (pestworld.org)
  • The virus, which is transmitted by the Asian tiger mosquito, triggers flu-like symptoms that can last for months and in rare cases can be fatal. (uni-muenchen.de)
  • If you believe you have Chikungunya, prevent mosquito bites for the first week of your illness. (cor.net)
  • State epidemiologist Anna Likos said in order for the virus to be transmitted from an infected person to an uninfected mosquito, they must be bitten within the first week of illness. (tbo.com)
  • It can cause illness for 7 to 10 days, however, and those infected with chikungunya are more likely to develop symptoms. (ms.gov)
  • Chikungunya virus is spread to people by the bite of an infected mosquito. (cdc.gov)
  • They spread the virus when they bite other people. (medlineplus.gov)
  • Let your provider know if you have traveled recently in an area where the virus is spread. (medlineplus.gov)
  • How does Chikungunya virus spread? (medicinenet.com)
  • Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe. (nih.gov)
  • So when you contract Chikungunya , the advice is to stay indoors on quarantine so that you don't spread it. (webpronews.com)
  • This image shows magnified particles of the Chikungunya virus, which is spread by mosquitos. (livescience.com)
  • If a person is infected and bitten by a mosquito, that mosquito may later spread the virus by biting another person. (cor.net)
  • An infected mosquito can then spread the virus to other people. (cor.net)
  • Vector control plays a key role in preventing the spread of Chikungunya virus. (medscape.com)
  • Matthew Aliota, a scientist at the UW-Madison School of Veterinary Medicine (SVM) and first author of the paper -- published today (July 1, 2016) in the journal Scientific Reports -- says the bacteria could present a "novel biological control mechanism," aiding efforts to stop the spread of Zika virus. (eurekalert.org)
  • There are not yet any approved Zika virus vaccines or antiviral medications, and ongoing mosquito control strategies have not been adequate to contain the spread of the virus. (eurekalert.org)
  • It is a re-emerging virus that has a risk to spread globally, given the expanding dissemination of its mosquito vectors. (plos.org)
  • Once again, human travel may have contributed to the rapid spread of the virus between islands because imported and autochthonous cases on Reunion Island occurred after a holiday period for residents on Reunion Island who often traveled to Madagascar. (thefreelibrary.com)
  • It's not the first Georgia case of chikungunya, which is spread through mosquito bites. (cogwriter.com)
  • Health officials in the Dominican Republic say a mosquito-borne virus has spread widely since making its first appearance in the country. (medicalxpress.com)
  • Originating from the tropical range, the Chikungunya virus has spread increasingly to the north in recent years, and already reached the southern United States. (uni-muenchen.de)
  • Chikungunya Virus Continues to Spread Throughout the U.S. (travelagentcentral.com)
  • Figuring out how the virus gets inside cells is considered a step toward slowing its spread. (wustl.edu)
  • Lead researcher, Dr. Lara Herrero, became interested in alphaviruses after becoming infected with Ross River virus in Western Australia in 2004. (medindia.net)
  • The findings, published Jan. 30 in the Proceedings of the National Academy of Sciences, could be a first step toward developing drugs to treat or prevent diseases caused by alphaviruses (such as chikungunya) and coronaviruses (such as SARS). (jhsph.edu)
  • The macrodomain in the chikungunya virus is similar in all alphaviruses, which encompass several viruses that have no cure or treatment such as Venezuelan equine encephalitis virus (which U.S. officials consider a potential bioterrorist threat) and the Mayaro virus, which some scientists have called the "next Zika. (jhsph.edu)
  • There are no specific treatments or vaccines for chikungunya and related viruses, known as arthritogenic alphaviruses. (wustl.edu)
  • Where is Chikungunya virus most prevalent? (medicinenet.com)
  • other cases had been reported in people who had recently traveled to areas where the virus is prevalent. (baltimoresun.com)
  • However, one of the mosquito species that carries the virus is prevalent in Brazil. (cogwriter.com)
  • Phylogenetic analysis identified 28 Asian genotype vi- and Reemerging Infectious Diseases, Muntinlupa City ruses and 3 ECSA genotype viruses (Figure 1). (cdc.gov)
  • Chikungunya has been on the U.S. public health radar for some time," said Dr. Lyle Petersen, director of the CDC's Division of Vector-Borne Diseases. (longislandpress.com)
  • Diagnosis of Chikungunya will first and foremost be by exclusion of other diseases such as dengue and measles, based on symptoms and travel history. (health.govt.nz)
  • We also examined antibodies to dengue viruses in the same sample (6) to increase our understanding of the epidemiologic features of both diseases. (thefreelibrary.com)
  • We expect to see West Nile virus cases each year because it is established in Maryland, but we are also looking for imported mosquito-borne diseases in Maryland residents,' Dr. Katherine Feldman, Maryland public health veterinarian, said in a statement. (baltimoresun.com)
  • Your doctor may order blood tests to look for Chikungunya or other similar diseases. (pestworld.org)
  • This Protocol allows BCW's mobile team to collect samples globally for Chikungunya and other emerging infectious diseases. (infectioncontroltoday.com)
  • But blood samples sent for testing in France confirmed the presence of chikungunya . (newscientist.com)
  • They did this by testing mosquito saliva for the presence of chikungunya virus. (southeastagnet.com)
  • There are currently no vaccines for chikungunya, but findings from a small study published today (Aug. 15) have shown promise that one could be developed. (livescience.com)
  • Officials are sounding the alarm about the growing national threat of another mosquito-borne tropical virus known as Chikungunya, which recently infected three Long Islanders, who contracted it while traveling abroad. (longislandpress.com)
  • WEST PALM BEACH - Health officials say that for the first time, an American has been infected with chikungunya by a mosquito here in the United States. (tbo.com)
  • That's why health officials believe the virus is spreading here: The two cases had not recently left the country. (tbo.com)
  • US health officials are on high alert as a mosquito-borne virus that yet has no cure has struck six of the US states. (rt.com)
  • The latest case of the virus has been confirmed by Tennessee officials as the resident of Madison County, has been tested positive for the virus. (rt.com)
  • State health officials said this week they have begun annual monitoring for West Nile and also for chikungunya, urging residents to avoid mosquito bites by using repellent, wearing long sleeves and pants when concerned about mosquito exposure, and clearing yards and other outside areas of potential mosquito breeding grounds. (baltimoresun.com)
  • The chikungunya virus won't likely kill you, but you won't forget having it, either, say health officials. (revolutionradio.org)
  • According to the 7online.com report, health officials said the virus is not contagious from person to person, is typically not life threatening and will likely resolve on its own. (travelagentcentral.com)
  • Bouquillard et al have reported the possible unmasking or occurrence of rheumatoid arthritis in patients infected with Chikungunya virus. (medscape.com)
  • A new study has found the molecular "handle" the virus uses to enter cells and cause arthritis. (wustl.edu)
  • But in up to half of patients, the virus can cause a debilitating form of arthritis that persists for months or even years. (wustl.edu)
  • Scientists have understood little about how chikungunya and related viruses cause arthritis. (wustl.edu)
  • Additional experiments showed that not just chikungunya but its arthritis-causing relatives - Mayaro, Ross River, O'nyongnyong and Barmah Forest viruses - require the protein to get into cells. (wustl.edu)
  • The results suggest that a compound that blocks the virus from attaching to Mxra8 on the surface of cells could prevent or reduce arthritis. (wustl.edu)