Chemotherapy-Induced Febrile Neutropenia
Antineoplastic Combined Chemotherapy Protocols
Taxoids
Chemotherapy, Adjuvant
Drug Administration Schedule
Granulocyte Colony-Stimulating Factor
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Treatment Outcome
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Paclitaxel
Doxorubicin
Neoplasms
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Infusions, Intravenous
Disease-Free Survival
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Combined Modality Therapy
Antineoplastic Agents, Phytogenic
Camptothecin
Maximum Tolerated Dose
Survival Rate
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Neoplasm Staging
Organoplatinum Compounds
Ifosfamide
Neoadjuvant Therapy
Hematologic Neoplasms
Dose-Response Relationship, Drug
Neoplasm Metastasis
Fluorouracil
Carcinoma, Non-Small-Cell Lung
Nausea
Anthracyclines
Epirubicin
Salvage Therapy
Prospective Studies
Neoplasm Recurrence, Local
Prognosis
Lymphoma, Non-Hodgkin
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Methotrexate
Opportunistic Infections
Drug Resistance, Neoplasm
Mucositis
An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Antibiotic Prophylaxis
Immunocompromised Host
Tegafur
Penicillanic Acid
Leucovorin
Disease Progression
Leukocyte Count
Antineoplastic Agents, Alkylating
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Ovarian Neoplasms
Follow-Up Studies
Bleomycin
Drug-Related Side Effects and Adverse Reactions
Antibiotics, Antineoplastic
Feasibility Studies
Bacteremia
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Topotecan
Antibodies, Monoclonal, Humanized
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Piperacillin
Colorectal Neoplasms
Antifungal Agents
Amikacin
Infection
Induction Chemotherapy
Antibodies, Monoclonal, Murine-Derived
Glutamates
Transplantation, Autologous
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Hematology
Prednisone
Leukemia, Myeloid, Acute
Randomized Controlled Trials as Topic
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Biosimilar Pharmaceuticals
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Ambulatory Care
Carcinoma, Small Cell
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Complement Hemolytic Activity Assay
A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay.
Risk Factors
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Thienamycins
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Sarcoma
Drug Therapy, Combination
Carcinoma, Squamous Cell
Remission Induction
Gram-Negative Bacterial Infections
Amphotericin B
Quality of Life
Treatment Failure
Prednisolone
Carcinoma
Pilot Projects
Dacarbazine
Lymphatic Metastasis
Carcinoma, Transitional Cell
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Risk Assessment
Neutrophils
Cephalosporins
Drug Combinations
Colony-Stimulating Factors
Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).
Gram-Positive Bacterial Infections
Diarrhea
Ceftazidime
Chemotherapy, Cancer, Regional Perfusion
Radiotherapy, Adjuvant
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Felty Syndrome
Leukocyte Elastase
Fatigue
Multivariate Analysis
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Melphalan
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Double-Blind Method
Testicular Neoplasms
Carmustine
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Inappropriate Prescribing
Mitomycin
Receptor, erbB-2
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Granulocyte-Macrophage Colony-Stimulating Factor
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Blood Cell Count
Anti-Infective Agents
Health Care Costs
The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.
Receptors, Granulocyte Colony-Stimulating Factor
Infusions, Intra-Arterial
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Drug Evaluation
Cost-Benefit Analysis
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Neoplasms, Germ Cell and Embryonal
Thiotepa
Calcitonin
Drug Therapy
Daunorubicin
Echinocandins
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Mannose-Binding Lectin
Vindesine
Osteosarcoma
Bone Marrow Transplantation
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Platinum
Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
Leukemia, Myeloid
Mortality, length of stay, and cost associated with hospitalized adult cancer patients with febrile neutropenia. (1/10)
BACKGROUND: Febrile neutropenia (FN) is a serious complication following chemotherapy and is associated with significant mortality and financial expenditure. The aim of this study was to evaluate risk factors for longer length of stay (LOS) and mortality and cost of treatment among hospitalized adults with cancer who developed febrile neutropenia in Thailand. MATERIALS AND METHODS: Information on illness of inpatients and casualties came from hospitals nationwide and from hospital withdrawals from the 3 health insurance schemes in fiscal 2010. The data covered 96% of the population and were analyzed by age groups, hospital level, and insurance year schemes in patients with febrile neutropenia. RESULTS: A total of 5,809 patients were identified in the study. The mortality rate was 14%. The median LOS was 8.67 days and 69% of patients stayed for longer than 5 days. On bivariate analysis, age, cancer type, and infectious complications (bacteremia/sepsis, hypotension, fungal infections, and pneumonia) were significantly associated with longer LOS and death. On multivariate analysis, acute leukemia and infectious complications were linked with longer LOS and death significantly. The median cost of hospitalized FN was THB 33,686 (USD 1,122) with the highest cost observed in acute leukemia patients. CONCLUSIONS: FN in adult patients results in significant mortality in hospitalized Thai patients. Factors associated with increased mortality include older age (>70), acute leukemia, comorbidity, and infectious complications. (+info)Febrile neutropenia in the tropics: a description of clinical and microbiological findings and their impact on inappropriate therapy currently used at an oncological reference center in Colombia. (2/10)
(+info)Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model. (3/10)
(+info)Lenalidomide plus cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab is safe and effective in untreated, elderly patients with diffuse large B-cell lymphoma: a phase I study by the Fondazione Italiana Linfomi. (4/10)
(+info)Comparison of pegfilgrastim prescribing practice to national guidelines at a university hospital outpatient oncology clinic. (5/10)
(+info)Bendamustine combined with rituximab for patients with relapsed or refractory diffuse large B cell lymphoma. (6/10)
(+info)Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). (7/10)
(+info)Study design: two long-term observational studies of the biosimilar filgrastim Nivestim (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia. (8/10)
(+info)
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Ovarian germ cell tumors
Remedial treatments to deal with chemotherapy-induced toxicities is through injection of granulocyte colony-stimulating factor ... specifically with observed febrile neutropenia, neurotoxicity, ototoxicity, and nephrotoxicity. ... For systemic chemotherapy (issued orally or intravenously), the regimen is standardised in every FIGO staging to comprise ... With a recurrence up to 15-25% for early-stage patients, adjuvant chemotherapy needs to couple with surgical resection of tumor ...
Máté Hidvégi
Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J Pediatric Hematol ... Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor ...
Angiopoietin
... concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia". BMC ... This quiescence or slow cell cycling of HSCs induced by Tie-2/Ang-1 signaling contributes to the maintenance of long-term ... It has been also implicated to play role in hepatocellular and endometrial carcinoma-induced angiogenesis. Experiments using ... 2013). "Kaposi's sarcoma-associated herpesvirus induces rapid release of angiopoietin-2 from endothelial cells". J Virol. 87 ( ...
Anthracycline
Use of anthracyclines has also been shown to be significantly associated with cycle 1 severe or febrile neutropenia. Other ... Angsutararux P, Luanpitpong S, Issaragrisil S (2015). "Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative ... It was first recognised to be related to the oxidative stress induced by anthracyclines. A more recent explanation has emerged ... Cytotoxicity is primarily due to inhibition of topoisomerase II after the enzyme induces a break in DNA, preventing religation ...
Docetaxel
Haematological adverse effects include neutropenia (95.5%), anaemia (90.4%), febrile neutropenia (11.0%) and thrombocytopenia ( ... As with all chemotherapy, adverse effects are common, and many side effects have been documented. Because docetaxel is a cell- ... When used with anticonvulsants, which induce CYP3A4, an increased dose of docetaxel may be required. Pre-treatment with ... It may be used by itself or along with other chemotherapy medication. It is given by slow injection into a vein. Common side ...
Filgrastim
Causes of neutropenia include chemotherapy and bone marrow transplantation. Filgrastim is also used to increase the number of ... Shortly after it was introduced, analyses of whether filgrastim is a cost-effective way of preventing febrile neutropenia ... Moore DC, Pellegrino AE (September 2017). "Pegfilgrastim-Induced Bone Pain: A Review on Incidence, Risk Factors, and Evidence- ... Exploration of Risk Factors for Febrile Neutropenia". Supportive Cancer Therapy. 3 (1): 36-46. doi:10.3816/SCT.2005.n.023. PMID ...
Lipegfilgrastim
... reduction in the duration of neutropenia and the incidence of febrile neutropenia in adults treated with cytotoxic chemotherapy ... "Lipegfilgrastim in the management of chemotherapy-induced neutropenia of cancer patients". Biologics. 10: 1-8. doi:10.2147/BTT. ... is a medication used to reduce the duration of neutropenia and the incidence of febrile neutropenia in adults. It is given by ... treatment comparison of lipegfilgrastim with pegfilgrastim and filgrastim for the reduction of chemotherapy-induced neutropenia ...
Cabazitaxel
Common adverse effects with cabazitaxel include neutropenia (including febrile neutropenia) and GIT side effects appeared ... September 2011). "Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in ... However, C20 and C25 did not demonstrate superiority for OS versus D75 in patients with chemotherapy-naïve mCRPC. Cabazitaxel ... Cabazitaxel was associated with more grade 3-4 neutropenia (81.7%) than mitoxantrone (58%). ...
Meropenem
... is frequently given in the treatment of febrile neutropenia. This condition frequently occurs in patients with ... Margolin, L (2004). "Impaired rehabilitation secondary to muscle weakness induced by meropenem". Clinical Drug Investigation. ... Antimicrobial Agents and Chemotherapy. 54 (7): 2974-8. doi:10.1128/AAC.01582-09. PMC 2897321. PMID 20479205. Yu Z, Pang X, Wu X ... Journal of Antimicrobial Chemotherapy. 72 (3): 782-790. doi:10.1093/jac/dkw476. PMC 5890718. PMID 27999041. "Hefny Pharma Group ...
Fever
A neutropenic fever, also called febrile neutropenia, is a fever in the absence of normal immune system function.[citation ... it is sometimes difficult to determine a febrile stage.[citation needed] Fever can also be behaviorally induced by ... This kind of fever is more commonly seen in people receiving immune-suppressing chemotherapy than in apparently healthy people ... Rarely a fever may trigger a febrile seizure, with this being more common in young children. Fevers do not typically go higher ...
Neutropenia
... has been shown in three clinical trials to significantly reduce the occurrence of chemotherapy-induced neutropenia and the ... when combined with profound neutropenia (febrile neutropenia), is considered a medical emergency and requires broad spectrum ... neutropenia, cyclic neutropenia, autoimmune neutropenia, and congenital neutropenia.[medical citation needed] Neutropenia that ... drug-induced neutropenia). Additionally, acute neutropenia can be commonly seen from people recovering from a viral infection ...
Piperacillin
1997). Febrile Neutropenia. Berlin, Heidelberg: Springer Berlin Heidelberg. doi:10.1007/978-3-642-60443-0. ISBN 978-3-540-61230 ... Allergic reactions can be induced from the side chains of β-lactam antibiotics such as amoxicillin, or antibodies surrounding ... Piperacillin/tazobactam Nosocomial Pneumonia Study Group". The Journal of Antimicrobial Chemotherapy. 43 (3): 389-97. doi: ... A dosage of 90mg/kg every 6 hours is suggested for infants and children diagnosed with neutropenia. Common side effects ...
Linezolid
... has been studied as an alternative to vancomycin in the treatment of febrile neutropenia in cancer patients when Gram ... Long-term use of linezolid has also been associated with chemotherapy-induced peripheral neuropathy, a progressive and enduring ... del Pino BM (23 February 2010). "Chemotherapy-induced Peripheral Neuropathy". NCI Cancer Bulletin. 7 (4): 6. Archived from the ... Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids ...
Acute radiation syndrome
... characterized by neutropenia and fever) is similar to the one used for other febrile neutropenic patients. However, important ... Ingestion of radioactive materials caused many radiation-induced cancers in the 1930s, but no one was exposed to high enough ... Journal of Antimicrobial Chemotherapy. 33 (1): 63-74. doi:10.1093/jac/33.1.63. ISSN 1460-2091. PMID 8157575. Patchen ML, Brook ... Individuals that develop neutropenia after exposure to radiation are also susceptible to irradiation damage in other tissues, ...
Bladder cancer
Febrile neutropenia (fever due to decrease in white blood cells) occurs in 10 to 14% and death due to toxicity in about 3-4%. ... cisplatin-based chemotherapy Metastatic disease but unfit for cisplatin-based chemotherapy: carboplatin-based chemotherapy ... Schistosoma eggs induces a chronic inflammatory state in the bladder wall resulting in tissue fibrosis. Higher levels of N- ... Role of adjuvant chemotherapy (chemotherapy after main treatment) is limited to people with high grade tumours (pT3/T4and/or N+ ...
List of skin conditions
Chemotherapy-induced hyperpigmentation Drug-induced acne Drug-induced angioedema Drug-related gingival hyperplasia Drug-induced ... Cyclic neutropenia Desquamative gingivitis Drug-induced ulcer of the lip Epidermization of the lip Epulis Epulis fissuratum ( ... Wallach D, Vignon-Pennamen MD (2006). "From acute febrile neutrophilic dermatosis to neutrophilic disease: forty years of ... induced Hair dye-induced Hair lotion-induced Hair spray-induced Hair straightener-induced Hair tonic-induced Houseplant-induced ...
Pixantrone
... and a significant reduction in febrile neutropenia. These findings could have major implications for treating patients with ... Anthracyclines are important chemotherapy agents. However, their use is associated with irreversible and cumulative heart ... Pixantrone inhibits antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production ... randomized clinical trial studied pixantrone to see how well it works compared to other chemotherapy drugs in treating patients ...
User:Jfdwolff
Febrile neutropenia, Friedreich's ataxia (T), Gastrointestinal bleeding, Gastroesophageal reflux disease, Gaucher's disease, ... Heparin-induced thrombocytopenia (T, good article since 1 January 2010), Hereditary hemorrhagic telangiectasia (T, good article ... Chemotherapy, Colchicine, Danazol (T), Dantrolene (T), Demeclocycline, Desiccated thyroid extract, Dexamethasone, Doxapram, ... Coeliac disease (T / featured since 26 March 2007), Colorectal cancer, Constipation, Contrast-induced nephropathy (T), ...
Analgesic
Refractory chemotherapy-induced nausea and vomiting; anorexia; neuropathic pain.. Dizziness, euphoria, paranoia, somnolence, ... For systemic use haematological side effects such as aplastic anaemia; agranulocytosis; leucopenia; neutropenia; etc. ... "Evidence on the use of paracetamol in febrile children". Bulletin of the World Health Organization. 81 (5): 367-72. PMC ... Pain; anaesthesia supplement; opioid-induced pruritus.. As per codeine. Respiratory depression is subject to ceiling effect. ...
Analgesic
Refractory chemotherapy-induced nausea and vomiting; anorexia; neuropathic pain.. Dizziness, euphoria, paranoia, somnolence, ... For systemic use haematological side effects such as aplastic anaemia; agranulocytosis; leucopenia; neutropenia; etc. ... "Evidence on the use of paracetamol in febrile children". Bulletin of the World Health Organization. 81 (5): 367-72. PMC ... Opioid-induced hyperalgesia is when exposure to opioids increases the sensation of pain (hyperalgesia) and can even make non- ...
Analgesic
Refractory chemotherapy-induced nausea and vomiting; anorexia; neuropathic pain.. Dizziness, euphoria, paranoia, somnolence, ... For systemic use haematological side effects such as aplastic anaemia; agranulocytosis; leucopenia; neutropenia; etc. ... "Evidence on the use of paracetamol in febrile children". Bulletin of the World Health Organization. 81 (5): 367-72. PMC ... Bannister K (June 2015). "Opioid-induced hyperalgesia: where are we now?". Current Opinion in Supportive and Palliative Care. 9 ...
Analgesic
Refractory chemotherapy-induced nausea and vomiting; anorexia; neuropathic pain.. Dizziness, euphoria, paranoia, somnolence, ... For systemic use haematological side effects such as aplastic anaemia; agranulocytosis; leucopenia; neutropenia; etc. ... "Evidence on the use of paracetamol in febrile children". Bulletin of the World Health Organization. 81 (5): 367-72. PMC ... Pain; anaesthesia supplement; opioid-induced pruritus.. As per codeine. Respiratory depression is subject to ceiling effect. ...
"Sociodemographics and breast cancer hormone receptor" by Vinodkumar Mugada, Raj Kiran Kolakota et al.
ALRN - Aileron Therapeutics Inc. • BioPharmCatalyst
... lives by helping them avoid life-threatening chemotherapy-related events such as severe neutropenia and febrile neutropenia. ... ALRN-6924 has demonstrated a protective effect against chemotherapy-induced bone marrow toxicities, including neutropenia, ... lives by helping them avoid life-threatening chemotherapy-related events such as severe neutropenia and febrile neutropenia. ... Grade 4 neutropenia and febrile neutropenia, as well as duration of Grade 4 neutropenia. An additional primary endpoint is the ...
Download PDF Clinical interpretation and practice of cancer chemotherapy Ebook
Beyond classical chemotherapy, treatment can involve multiple classes of therapies, such as immune check- point inhibitors. ... Clinical Guide to Antineoplastic Therapy: A Chemotherapy Handbook (Fourth Edition) The landscape of cancer treatment is ... cancer regardless of absolute neutrophil count and without G-CSF does not increase chemotherapy-induced febrile neutropenia, ... How does chemotherapy work. Chemotherapy works by stopping or slowing the growth of cancer cells, which grow and divide quickly ...
systematic review conference
Dennis Grauer | School of Pharmacy
Empiric use of daptomycin for febrile neutropenia in hematopoietic stem cell transplant patients colonized with vancomycin- ... Fleer, R. Grauer, D. Henry, D. Rockey, M. & Hosmer, K. (2018). Medication interactions with oral chemotherapy agents: a focus ... Burke, E. Grauer, D. Henry, D. Neupane, P. & Rockey, M. . (12/31/2016). Assessment of cetuximab-induced infusion reactions and ... Empiric use of daptomycin for febrile neutropenia in hematopoietic stem cell transplant patients colonized with vancomycin- ...
JHOP - December 2019 Vol 9, No 4
Preventing Chemotherapy-Induced Infertility in Female Patients. By Shiela McCollam, PharmD, BCPS; Colleen Shipman, PharmD, MPH ... of Intravenous Fluid Shortages on the Time to Antibiotic Administration in the Treatment of Patients with Febrile Neutropenia ... Chemotherapy Administration Sequencing: An Update on the Current Literature. Alanna D. Lehman, PharmD, BCOP; Anna Howard, ... Use of Nanoparticle Albumin-Bound Paclitaxel in Patients with Breast Cancer and Paclitaxel-Induced Pneumonitis: Single-Center ...
Browsing DSpace : HUSCAP
Clinical impact of cycling the administration of antibiotics for febrile neutropenia in Japanese patients with hematological ... R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease. -. Journal of experimental ... Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. -. Case reports in ... A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin αIIbβ3 in autosomal dominant ...
NHS Dudley Health Economy Medicines Formulary
Naloxegol for treating opioid‑induced constipation - NICE TAG TA345 * Methylnaltrexone bromide for treating opioid-induced ... Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy- NICE TAG TA428. 1.1Pembrolizumab is ... 4.8.3 Febrile convulsions * 4.9 Drugs used in parkinsonism and related disorders * 4.9.1 Dopaminergic drugs used in Parkinsons ... 9.1.6 Drugs used in neutropenia * 9.1.7 Drugs used to mobilise stem cells ...
NHS Dudley Health Economy Medicines Formulary
Naloxegol for treating opioid‑induced constipation - NICE TAG TA345 * Methylnaltrexone bromide for treating opioid-induced ... Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy - NICE TAG TA374 ... 4.8.3 Febrile convulsions * 4.9 Drugs used in parkinsonism and related disorders * 4.9.1 Dopaminergic drugs used in Parkinsons ... 9.1.6 Drugs used in neutropenia * 9.1.7 Drugs used to mobilise stem cells ...
NHS Dudley Health Economy Medicines Formulary
Naloxegol for treating opioid‑induced constipation - NICE TAG TA345 * Methylnaltrexone bromide for treating opioid-induced ... Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy - NICE TAG TA374 ... 4.8.3 Febrile convulsions * 4.9 Drugs used in parkinsonism and related disorders * 4.9.1 Dopaminergic drugs used in Parkinsons ... 9.1.6 Drugs used in neutropenia * 9.1.7 Drugs used to mobilise stem cells ...
NHS Dudley Health Economy Medicines Formulary
Naloxegol for treating opioid‑induced constipation - NICE TAG TA345 * Methylnaltrexone bromide for treating opioid-induced ... Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy - NICE TAG TA374 ... 4.8.3 Febrile convulsions * 4.9 Drugs used in parkinsonism and related disorders * 4.9.1 Dopaminergic drugs used in Parkinsons ... 9.1.6 Drugs used in neutropenia * 9.1.7 Drugs used to mobilise stem cells ...
NHS Dudley Health Economy Medicines Formulary
Naloxegol for treating opioid‑induced constipation - NICE TAG TA345 * Methylnaltrexone bromide for treating opioid-induced ... Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy - NICE TAG TA374 ... 4.8.3 Febrile convulsions * 4.9 Drugs used in parkinsonism and related disorders * 4.9.1 Dopaminergic drugs used in Parkinsons ... 9.1.6 Drugs used in neutropenia * 9.1.7 Drugs used to mobilise stem cells ...
Patients7
- ALRN ), a chemoprotection oncology company focused on fundamentally transforming the experience of chemotherapy for cancer patients, announced today that Manuel Aivado, M.D., Ph.D., President and Chief Executive Officer, is scheduled to participate in a fireside chat at the William Blair Biotech Focus Conference 2021 at 3:00 p.m. (biopharmcatalyst.com)
- Aileron is a clinical stage chemoprotection oncology company focused on fundamentally transforming the experience of chemotherapy for cancer patients. (biopharmcatalyst.com)
- By reducing or eliminating multiple chemotherapy-induced side effects, ALRN-6924 may improve patients' quality of life by enabling them to better tolerate chemotherapy. (biopharmcatalyst.com)
- It also may save patients' lives by helping them avoid life-threatening chemotherapy-related events such as severe neutropenia and febrile neutropenia. (biopharmcatalyst.com)
- Our vision is to bring chemoprotection to patients with p53-mutated cancers, which represent approximately 50% of cancer patients, regardless of type of cancer or chemotherapy. (biopharmcatalyst.com)
- Thus, a systematic review on the use of colony-stimulating factors in patients with hematologic malignancies will be a far greater undertaking than a systematic review of colony-stimulating factors in preventing chemotherapy-induced febrile neutropenia in children with acute lymphoblastic leukemia. (nichi.com)
- Medication interactions with oral chemotherapy agents: a focus on the BCR-ABL tyrosine kinase inhibitors in patients with chronic myeloid leukemia. (ku.edu)
Side effects1
- Free Book Cancer Chemotherapy In Clinical Practice # Uploaded By Barbara Cartland, practical aspects covering dosing and drug delivery together with an extensive discussion of possible side effects and their management chemotherapy in the management of cancer explaining the place of drug treatment and the outcomes that can be. (naba-hairstreak.com)
Treatment5
- Intended as an introductory text for junior doctors, nurses and medical students, Cancer Chemotherapy in Clinical Practice is divided into three sections: The Theoretical Basis of Cancer Chemotherapy - following a historical introduction the different treatment modalities are explained in. (naba-hairstreak.com)
- Clinical Interpretations and Practice of Cancer Chemotherapy limits its approach to the drugrelated aspects of the treatment of cancer. (naba-hairstreak.com)
- This book is intended as a basic overview of the drug treatment of cancer for junior doctors and specialist nurses who come into contact with people having chemotherapy as part of their day-- day work. (naba-hairstreak.com)
- students cancer chemotherapy in clinical practice is divided into three sections the theoretical basis of cancer chemotherapy following a historical introduction the different treatment modalities are explained in the context of basic tumor biology the first use of the word chemotherapy is credited to paul ehrlich who used it to. (naba-hairstreak.com)
- cancer chemotherapy in clinical practice Posted By Patricia Cornwell Public Library TEXT ID e Online PDF Ebook Epub Library introduction the different treatment modalities are explained in the context of basic tumor biology the last decade has seen many dramatic changes in cancer chemotherapy. (naba-hairstreak.com)
Cancer8
- This precision medicine-driven approach is designed to selectively protect multiple healthy cell types throughout the body from chemotherapy while ensuring we do not protect cancer cells. (biopharmcatalyst.com)
- As a result, healthy cells are spared from chemotherapeutic destruction while chemotherapy continues to kill cancer cells. (biopharmcatalyst.com)
- 4 edition of Clinical interpretation and practice of cancer chemotherapy found in the catalog. (naba-hairstreak.com)
- Cancer -- Chemotherapy. (naba-hairstreak.com)
- Cancer Chemotherapy: Principles and Practice. (naba-hairstreak.com)
- cancer chemotherapy in clinical practice Posted By Richard Scarry Library TEXT ID c2 Online PDF Ebook Epub Library fields of cytotoxic and hormonal therapy this book summarises the whole range of systemic cancer Clinical interpretation and practice of cancer chemotherapy book. (naba-hairstreak.com)
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