Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.
Treatment process involving the injection of fluid into an organ or tissue.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
The circulation of blood through the CORONARY VESSELS of the HEART.
The circulation of the BLOOD through the LUNGS.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
The flow of BLOOD through or around an organ or region of the body.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
The creation and display of functional images showing where the blood flow reaches by following the distribution of tracers injected into the blood stream.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The circulation of blood through the BLOOD VESSELS of the BRAIN.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Tumors or cancer of the human BREAST.
The hollow, muscular organ that maintains the circulation of the blood.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tumors or cancer of the LUNG.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Tumors or cancer of the STOMACH.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Tumors or cancer of the COLON.
Tumors or cancer of the PROSTATE.
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
An organoplatinum compound that possesses antineoplastic activity.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Elements of limited time intervals, contributing to particular results or situations.
Antimetabolites that are useful in cancer chemotherapy.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A cell line derived from cultured tumor cells.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Organic compounds which contain platinum as an integral part of the molecule.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A malignant epithelial tumor with a glandular organization.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Tumors or cancer of the LIVER.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.
Tumors or cancer of the URINARY BLADDER.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Tumors or cancer of the UTERINE CERVIX.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Tumors or cancer of the RECTUM.
A subspecialty of internal medicine concerned with the study of neoplasms.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A decrease in the number of NEUTROPHILS found in the blood.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Antibodies produced by a single clone of cells.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Tumors or cancer of the PERITONEUM.
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Tumors or cancer of the ESOPHAGUS.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Transplantation of an individual's own tissue from one site to another site.
Substances used to allow enhanced visualization of tissues.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
The return of a sign, symptom, or disease after a remission.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.
Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
DNA present in neoplastic tissue.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Transplantation between animals of different species.
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Surgical procedure to remove one or both breasts.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
An anthracenedione-derived antineoplastic agent.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
A general term for various neoplastic diseases of the lymphoid tissue.
An alkylating agent of value against both hematologic malignancies and solid tumors.
The action of a drug in promoting or enhancing the effectiveness of another drug.
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
Treatment that combines chemotherapy with radiotherapy.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Drugs used to prevent NAUSEA or VOMITING.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Cyclic hydrocarbons that contain multiple rings and share one or more atoms.
Inorganic compounds which contain platinum as the central atom.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer. (1/241)

PET with L-[1-11C]-tyrosine (TYR) was investigated in patients undergoing hyperthermic isolated limb perfusion (HILP) with recombinant tumor necrosis factor alpha (rTNF-alpha) and melphalan for locally advanced soft-tissue sarcoma and skin cancer of the lower limb. METHODS: Seventeen patients (5 women, 12 men; age range 24-75 y; mean age 52 y) were studied. TYR PET studies were performed before HILP and 2 and 8 wk afterwards. The protein synthesis rates (PSRs) in nanomoles per milliliter per minute were calculated. After final PET studies, tumors were resected and pathologically examined. Patients with pathologically complete responses (pCR) showed no viable tumors after treatment. Those with pathologically partial responses (pPR) showed various amounts of viable tumors in the resected tumor specimens. RESULTS: Six patients (35%) showed a pCR and 11 patients (65%) showed a pPR. All tumors were depicted as hot spots on PET studies before HILP. The PSR in the pCR group at 2 and 8 wk after perfusion had decreased significantly (P < 0.05) in comparison to the PSR before HILP. A significant difference was found in PSR between the pCR and pPR groups at 2 and at 8 wk (P < 0.05). Median PSR in nonviable tumor tissue was 0.62 and ranged from 0.22 to 0.91. With a threshold PSR of 0.91, sensitivity and specificity of TYR PET were 82% and 100%, respectively. The predictive value of a PSR > 0.91 for having viable tumor after HILP was 100%, whereas the predictive value of a PSR < or = 0.91 for having nonviable tumor tissue after HILP was 75%. The 2 patients in the pPR groups with a PSR < 0.91 showed microscopic islets of tumor cells surrounded by extensive necrosis on pathological examination. CONCLUSION: Based on the calculated PSR after HILP, TYR PET gave a good indication of the pathological outcome. Inflammatory tissue after treatment did not interfere with viable tumor on the images, suggesting that it may be worthwhile to pursue TYR PET in other therapy evaluation settings.  (+info)

In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats. (2/241)

Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable.  (+info)

Metabolism of [14C]phenol in the isolated perfused mouse liver. (3/241)

A previous report from this laboratory focused on the metabolism of [14C]benzene (BZ) in the isolated, perfused, mouse liver (C. C. Hedli, et al., 1997, Toxicol. Appl. Pharmacol. 146, 60-68). Whereas administration of BZ to mice results in bone marrow depression (R. Snyder et al., 1993, Res. Commun. Chem. Pathol. Pharmacol. 20, 191-194), administration of phenol (P), the major metabolite of BZ, does not. It was, therefore, of interest to determine whether the metabolic fate of P produced during BZ metabolism differed from that of P metabolized in the absence of BZ. Mouse livers were perfused with a solution of [14C]P in both the orthograde (portal vein to central vein) and retrograde (central vein to portal vein) direction to investigate the metabolic zonation of enzymes involved in P hydroxylation and conjugation. Perfusate samples were collected, separated by HPLC, and tested for radioactivity. Unconjugated metabolites were identified by comparing their retention times with nonradiolabeled standards, which were detected by UV absorption. Conjugated metabolites were identified and collected on the basis of radiochromatogram results, hydrolyzed enzymatically, and identified by co-chromatography with unlabeled BZ metabolites. The objective was to compare and quantify the metabolites formed during the perfusion of P in the orthograde and retrograde directions and to compare the orthograde P-perfusion results with the orthograde BZ results reported previously. Regardless of the direction of P perfusion, the major compounds released from the liver were P. phenylgucuronide, phenylsulfate, hydroquinone (HQ), and HQ glucuronide. A comparison of the results of perfusing P in the orthograde versus the retrograde direction showed that more P was recovered unchanged and more HQ was formed during retrograde perfusion. The results suggest that enzymes involved in P hydroxylation are generally closer to the central vein than those involved in conjugation, and that during retrograde perfusion, P metabolism may be limited by the sub-optimal conditions of perfusion. Comparison of the orthograde perfusion studies of P and BZ revealed that a larger percentage of the radioactivity released from the liver was identified as unconjugated HQ after BZ perfusion than after P perfusion. In addition, the amount of radioactivity covalently bound to liver macromolecules was measured after each perfusion and determined to be proportional to the amount of HQ and HQG detected in the perfusate samples.  (+info)

Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats. (4/241)

An isolated limb perfusion (ILP) model using soft tissue sarcoma-bearing rats was used to study prerequisites for an effective ILP, such as oxygenation of the perfusate, temperature of the limb, duration of the perfusion and concentration of tumour necrosis factor (TNF). Combination of 50 microg TNF and 40 microg melphalan demonstrated synergistic activity leading to a partial and complete response rate of 71%. In comparison to oxygenated ILP, hypoxia was shown to enhance anti-tumour activity of melphalan alone and TNF alone but not of their combined use. Shorter perfusion times decreased anti-tumour responses. At a temperature of 24-26 degrees C, anti-tumour effects were lost, whereas temperatures of 38-39 degrees C or 42-43 degrees C resulted in higher response rates. However, at 42-43 degrees C, local toxicity impaired limb function dramatically. Synergy between TNF and melphalan was lost at a dose of TNF below 10 microg in 5 ml perfusate. We conclude that the combination of TNF and melphalan has strong synergistic anti-tumour effects in our model, just as in the clinical setting. Hypoxia enhanced activity of melphalan and TNF alone but not the efficacy of their combined use. For an optimal ILP, minimal perfusion time of 30 min and minimal temperature of 38 degrees C was mandatory. Moreover, the dose of TNF could be lowered to 10 microg per 5 ml perfusate, which might allow the use of TNF in less leakage-free or less inert perfusion settings.  (+info)

Hyperthermic isolated limb perfusion with tumor necrosis factor-alpha and melphalan in patients with locally advanced soft tissue sarcomas: treatment response and clinical outcome related to changes in proliferation and apoptosis. (5/241)

Hyperthermic isolated limb perfusion with tumor necrosis factor-alpha and melphalan (HILP-TM) with or without IFN-gamma is a promising local treatment in patients with locally advanced extremity soft tissue sarcomas (STSs), with response rates of up to 84%. The mechanisms of the treatment response are poorly understood. Here, we determined the HILP-TM-induced changes in mitotic activity, proliferation, and apoptosis in 37 STSs; the additional effect of IFN-gamma; and the association of HILP-TM with treatment response and clinical outcome. On archival material, obtained before and 6-8 weeks after HILP-TM with (n = 15) or without (n = 22) IFN-gamma, the number of mitoses was counted, and the proliferation fraction was determined by immunohistological staining for the proliferation associated Ki-67 antigen (MIB1). Apoptosis was visualized by enzymatic detection of DNA fragmentation (terminal deoxynucleotidyl transferase-mediated nick end labeling method). Clinical and histological response, follow-up status, and survival were recorded. The number of mitoses dropped 57% and proliferation rate decreased with 40% after HILP-TM, whereas the amount of apoptosis after HILP-TM more than doubled as before HILP-TM. The addition of IFN-gamma to HILP-TM did not influence the changes in tumor parameters and did not affect treatment response. A better clinical response to HILP-TM was correlated with high mitotic activity and low amount of apoptosis in tumor samples before HILP-TM. Patients with highly proliferative STS before and after HILP-TM had a relatively poor prognosis. Furthermore, patients who developed distant metastases after HILP-TM had a relatively high number of dividing cells in the tumor remnants after treatment.  (+info)

TNF-alpha augments intratumoural concentrations of doxorubicin in TNF-alpha-based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects. (6/241)

We have shown previously that isolated limb perfusion (ILP) in sarcoma-bearing rats results in high response rates when melphalan is used in combination with tumour necrosis factor alpha (TNF-alpha). This is in line with observations in patients. Here we show that ILP with doxorubicin in combination with TNF-alpha has comparable effects in two different rat sarcoma tumour models. The addition of TNF-alpha exhibits a synergistic anti-tumour effect, resulting in regression of the tumour in 54% and 100% of the cases for the BN175-fibrosarcoma and the ROS-1 osteosarcoma respectively. The combination is shown to be mandatory for optimal tumour response. The effect of high dose TNF-alpha on the activity of cytotoxic agents in ILP is still unclear. We investigated possible modes by which TNF-alpha could modulate the activity of doxorubicin. In both tumour models increased accumulation of doxorubicin in tumour tissue was found: 3.1-fold in the BN175 and 1.8-fold in the ROS-1 sarcoma after ILP with doxorubicin combined with TNF-alpha in comparison with an ILP with doxorubicin alone. This increase in local drug concentration may explain the synergistic anti-tumour responses after ILP with the combination. In vitro TNF-alpha fails to augment drug uptake in tumour cells or to increase cytotoxicity of the drug. These findings make it unlikely that TNF-alpha directly modulates the activity of doxorubicin in vivo. As TNF-alpha by itself has no or only minimal effect on tumour growth, an increase in local concentrations of chemotherapeutic drugs might well be the main mechanism for the synergistic anti-tumour effects.  (+info)

Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver. (7/241)

A phase I dose-escalation study was performed to determine whether isolated hepatic perfusion (IHP) with melphalan (L-PAM) allows exposure of the liver to much higher drug concentrations than clinically achievable after systemic administration and leads to higher tumour concentrations of L-PAM. Twenty-four patients with colorectal cancer confined to the liver were treated with L-PAM dosages escalating from 0.5 to 4.0 mg kg(-1). During all IHP procedures, leakage of perfusate was monitored. Duration of IHP was aimed at 60 min, but was shortened in eight cases as a result of leakage from the isolated circuit. From these, three patients developed WHO grade 3-4 leukopenia and two patients died due to sepsis. A reversible elevation of liver enzymes and bilirubin was seen in the majority of patients. Only one patient was treated with 4.0 mg kg(-1) L-PAM, who died 8 days after IHP as a result of multiple-organ failure. A statistically significant correlation was found between the dose of L-PAM, peak L-PAM concentrations in perfusate (R = 0.86, P< or =0.001), perfusate area under the concentration-time curve (AUC; R = 0.82, P<0.001), tumour tissue concentrations of L-PAM (R = 0.83, P = 0.011) and patient survival (R = 0.52, P = 0.02). The peak L-PAM concentration and AUC of L-PAM in perfusate at dose level 3.0 mg kg(-1) (n = 5) were respectively 35- and 13-fold higher than in the systemic circulation, and respectively 30- and 5-fold higher than reported for high dose oral L-PAM (80-157 mg m(-2)) and autologous bone marrow transplantation. Median survival after IHP (n = 21) was 19 months and the overall response rate was 29% (17 assessable patients; one complete and four partial remissions). Thus, the maximally tolerated dose of L-PAM delivered via IHP is approximately 3.0 mg kg(-1), leading to high L-PAM concentrations at the target side. Because of the complexity of this treatment modality, IHP has at present no place in routine clinical practice.  (+info)

A phase I-II study of isolated hepatic perfusion using melphalan with or without tumor necrosis factor for patients with ocular melanoma metastatic to liver. (8/241)

There are no satisfactory treatment options for patients with ocular melanoma metastatic to liver, and after liver metastases are identified, median survival is only between 2 and 7 months. Because liver metastases are the sole or life-limiting component of disease in the vast majority of patients who recur, we reasoned that complete vascular isolation and perfusion of the liver might result in clinically meaningful regression of disease. Between September 1994 and July 1999, 22 patients (13 women and 9 men; mean age, 49 years) with ocular melanoma metastatic to liver were treated with a 60-min hyperthermic isolated hepatic perfusion (IHP) using melphalan alone (1.5-2.5 mg/kg, n = 11) or with tumor necrosis factor (TNF, 1.0 mg, n = 11). Via a laparotomy, IHP inflow was via the hepatic artery alone (n = 17) or hepatic artery and portal vein (n = 5) and outflow from an isolated segment of inferior vena cava. Most patients had advanced tumor burden with a mean percentage of hepatic replacement of 25% (range, 10-75%) and a median number of metastatic nodules of 25 (range, 5 to >50). Complete vascular isolation was confirmed in all patients using a continuous intraoperative leak monitoring technique with 131I radiolabeled albumin. There was one treatment mortality (5%). The overall response rate in 21 patients was 62% including 2 radiographic complete responses (9.5%) and 11 partial responses (52%). The overall median duration of response was 9 months (range, 5-50) and was significantly longer in those treated with TNF than without (14 versus 6 months, respectively; P = 0.04). Overall median survival in 22 patients was 11 months. These data indicate that a single 60-min IHP can result in significant regression of advanced hepatic metastases from ocular melanoma. TNF appears to significantly prolong the duration of response.  (+info)

This phase I/II trial studies the safety, best dose and effectiveness of targeted gene therapy combined with isolated limb infusion (ILI) of melphalan and dactinomycin for treating patients with advanced extremity melanoma that cannot be removed by surgery. Adding gene therapy to a standard chemotherapy regimen in the isolated limb may enhance anti-cancer effects by inducing a systemic immune response against the tumor cells ...
TY - JOUR. T1 - Isolated limb infusion for in-transit malignant melanoma of the extremity. T2 - A well-tolerated but less effective alternative to hyperthermic isolated limb perfusion. AU - Beasley, Georgia M.. AU - Petersen, Rebecca P.. AU - Yoo, Jin. AU - McMahon, Nicole. AU - Aloia, Thomas. AU - Petros, William. AU - Sanders, Gretchen. AU - Cheng, Tsung Yen. AU - Pruitt, Scott K.. AU - Seigler, Hilliard. AU - Tyler, Douglas. PY - 2008/8. Y1 - 2008/8. N2 - Background: Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusion (HILP), in treating extremity in-transit melanoma. Methods: Variables from a prospective single institution database of 120 regionally treated melanoma patients (1995-2007) were compared using chi-square analysis. This included 61 consecutive ILI treatments in 58 patients and 59 HILP ...
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TY - CHAP. T1 - Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion. AU - Heller, Charles K.. AU - Pingpank, James F.. AU - Libutti, Steven K.. PY - 2009/12/9. Y1 - 2009/12/9. KW - Hepatic arterial infusion (HAI). KW - Inferior vena cava (IVC). KW - Isolated hepatic perfusion and percutaneous hepatic perfusion. KW - Metastatic neuroendocrine tumors (MNET). KW - National institutes of health (NIH). KW - Percutaneous hepatic perfusion. KW - Tumor necrosis factor (TNF). KW - Veno-occlusive disease (VOD). UR - http://www.scopus.com/inward/record.url?scp=84948987546&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84948987546&partnerID=8YFLogxK. U2 - 10.1002/9781444317053.ch15. DO - 10.1002/9781444317053.ch15. M3 - Chapter. AN - SCOPUS:84948987546. SN - 9781444317053. SN - 9781405179768. SP - 164. EP - 172. BT - Malignant Liver Tumors: Current and Emerging Therapies: Third Edition. PB - Wiley Blackwell. ER - ...
TY - JOUR. T1 - Technique and results of hyperthermic isolated hepatic perfusion with tumor necrosis factor and melphalan for the treatment of unresectable hepatic malignancies. AU - Libutti, Steven K.. AU - Bartlett, David L.. AU - Fraker, Douglas L.. AU - Alexander, H. Richard. PY - 2000. Y1 - 2000. N2 - Background: For a variety of histologies, the liver represents the only or the dominant site of metastatic disease. Regional treatment of the liver has the theoretic advantage of maximizing drug delivery while minimizing systemic toxicity. This article describes the technique of isolated hepatic perfusion using tumor necrosis factor and melphalan under conditions of moderate hyperthermia for the treatment of unresectable liver tumors. Study Design: Fifty patients with biopsy-proved unresectable primary or metastatic cancer to the liver were treated. Isolated hepatic perfusion was performed for 60 minutes under conditions of moderate hyperthermia during a laparotomy with inflow through the ...
As well known, process identification is very important in process control. A Open-loop identification method is proposed in this paper. The identification object is a simulated facility with constant temperature hyperthermic perfusion treatment on bladder cancer. Open-loop step response is applied ,the process input and the resulted output response are logged, and the improved area method is adopted, from which the parameters of a first-order plus dead-time model can be estimated. Based on some PID tuning rule the closed loop experiments have been conducted. The experimental results have shown that the proposed method has good identification accuracy and is insensitive to the noise. Furthermore, the experiments of the closed loop control system have also indicated the design closed loop control system is valid.
In the largest single-institution regional therapy series reported to date, we found that although ILI is effective and well-tolerated, HILP is a more definitive way to control advanced disease.
Patients with pancreatic carcinoma generally have poor prognosis, since it is typically detected too late. Furthermore, it is located near anatomically important structures such as the bile ducts and major blood vessels, which complicates access to the tumor. At the time of diagnosis, only 10% of these tumours are still operable.. For advanced pancreatic carcinoma, chemotherapy only prolongs life expectancy in the range of 2 to 6.5 months. Patients previously treated with radiation and chemotherapy are rarely included in the studies because of their poor prognosis. As a result, very few such studies exist. One study (Author: Berlin JD et al) reports a median survival time (50%) of 6.7 months in a large group of 322 previously treated patients, and a 25% survival period of 10.5 months.. More recent studies of advanced, inoperable pancreatic carcinoma using newer agents could not demonstrate greater than 20-25% survival rate beyond one year. Regional chemotherapy for regionally advanced, ...
The study, conducted over a 22-year period from 1994 to 2016, is the largest one to date of limb preservation using isolated limb infusion for sarcoma. Advocates for [isolated limb infusion] in these patients would argue that, with similar long-term survival data and meaningful overall response rates, patients would much prefer a treatment that preserves the affected extremity to one that does not, Dr. Mullinax said. Isolated limb infusion has historically been used primarily for melanoma of the extremities, and the use of this technique in sarcoma is a novel approach. Sarcoma is a rare type of cancer in the extremities with several different subtypes; the study patients who underwent isolated limb infusion had 17 different subtypes of sarcoma ...
Abstract Purpose: Isolated limb perfusion (ILP) with hyperthermia is an effective treatment for in-transit metastases of malignant melanoma in the extremities. Preclinical studies have shown that hyperthermia may induce an immunogenic death of tumour cells. We therefore decided to study whether ILP may induce tumour-specific immune responses in the clinical setting. Method: The number of Melan-A/Mart-1 specific CD8+ T cells, as well as other phenotypically different immune cells, was recorded in peripheral blood in 12 HLA-A2+ patients with in-transit metastases undergoing hyperthermic ILP with melphalan. Results: All patients underwent ILP without any complication and with an overall response rate of 83%. No substantial changes in the number of circulating T-cells, B-cells, NK-cells or monocytes were observed during follow-up. Four out of 12 patients showed an elevation of Melan-A+ CD8+ T-cells 4 weeks after ILP. Conclusion: We here report our preliminary observations that a small increase in ...
Cavity Circulation Perfusion Thermo-chemotherapy System-HYPERTHERMIC PERFUSION-Cavity Circulation Perfusion Thermo-chemotherapy System
Background There is increasing evidence that tumor hypoxia plays a significant role in the chemoresistance of melanoma, but to our knowledge, real-time tumor oxygenation during isolated limb infusion...
Isolated hepatic perfusion (IHP) is a surgical technique used to treat non-resectable liver cancers. Learn more about this surgical technique.
This talk will focus on the current literature associated with regional limb perfusion and provide technical details of performing regional limb perfusions in the field. In addition, cases and indications of use will be discussed along with common pitfalls or failures seen with the procedure that may lead to a failure in response to treatment. There will be a discussion of the prognosis seen with its use verses without. ...
Regional perfusion therapy can be an option for treating metastases which are cancers that started in one part of the body and have spread to an adjacent part.
Find best value and selection for your MANFRED MANNS EARTH BAND Good Earth UK LP 1974 ILPS search on eBay. World's leading marketplace.
Hello All, A review of the Source Hydration ILPS system. For a while now I have been searching for a hydration system to integrate into my LBT 6094 Slick carrier. The idea was is that the Slick being the base system for all my current rigs I would like to keep the hydration on it. Some requiremen...
Implementing this complex technique which requires highly skilled centres, increases the survival of patients with ovarian and colon cancer Having a
TY - JOUR. T1 - Pharmacokinetics, toxicity, and short-term results of cisplatin hyperthermic isolated limb perfusion for soft-tissue sarcoma and melanoma of the extremities. AU - Pommier, Rodney F.. AU - Moseley, H. Stephens. AU - Cohen, Jordan. AU - Huang, Chu S.. AU - Townsend, Rae Ann. AU - Fletcher, William S.. N1 - Funding Information: From the Division of Surgical Oncology, Oregon Health Sciences University, Portland, Oregon. Supported in part by the American Cancer Society Clinical Fellowship no. 87191, the OregOn Chapter of the Order of the Eastern Star, and the Ladies Auxiliary of the Veterans of Foreign Wars, Portland, Oregon.. PY - 1988/5. Y1 - 1988/5. N2 - Fifty-nine patients with melanoma or soft tissue sarcoma of the extremities underwent hyperthermic isolated limb perfusion utilizing cisplatin and wide local excision. Doses of cisplatin ranged from 0.75 to 2 mg/kg. The mortality and morbidity rates were 0 and 6.8 percent, respectively. Pharmacokinetic studies indicate that ...
Quimioterapia hipertérmica intraperitoneal transoperatória: o que a enfermagem precisa saber [Intraoperative hyperthermic intraperitoneal chemotherapy: what nurses should know]
Tel Aviv Sourasky Medical Center (Ichilov Medical Center) offers Regional Chemotherapy procedures starting from Price on request and it is specialized in Oncology treatments.
Percutaneous hepatic perfusion (PHP) is a minimally invasive treatment that delivers high-dose chemotherapy directly to metastatic melanoma in the liver. Unlike traditional chemotherapy, in which medications circulate throughout the entire body, PHP specifically targets the liver only, which can help reduce the side effects commonly associated with chemo. This approach allows oncologists to treat tumors with much higher doses of chemotherapy than would otherwise be possible when given systemically (through the peripheral veins).. At Moffit Cancer Center, percutaneous hepatic perfusion is offered to treat melanoma that has spread to the liver (as often occurs with ocular melanomas), and select other tumors metastatic to the liver. Prior to recommending this therapy to a patient, our oncologists and interventional radiologists will assess a number of factors, including the following, to ensure that PHP is a suitable option:. ...
Background: Angiosarcomas are rare and aggressive soft-tissue sarcomas. The only potential curative treatment is complete surgical excision. This study reports the outcome of isolated limb perfusion (ILP) with high-dose melphalan and tumour necrosis factor a for locally advanced angiosarcoma. Material and methods: All patients who underwent an ILP for angiosarcomas between 1991 and 2016 in three tertiary referral centres were identified from prospectively maintained data-bases. Results: A total of 39 patients were included, with a median follow-up of 18 months (interquartile range 6.1-60.8). Of these patients, 23 (58.9%) patients had a complete response (CR) after ILP, 10 (25.6%) had a partial response, 4 (10.3%) had stable disease and 2 (5.1%) patients had progressive disease immediately after ILP. A total of 22 patients developed local progression (56.4%), whereas nine (23.1%) developed distant metastases. The patients with CR had a significantly prolonged median local progression-free ...
Definition of in-transit metastasis. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
PURPOSE OF REVIEW: The recent discovery of effective systemic treatments for melanoma has dramatically improved the prognosis for patients with advanced disease. As a result, the multidisciplinary management of melanoma has evolved significantly. In the past decades surgery was reserved for symptomatic palliation in patients with metastatic melanoma. Today surgical treatment of patients responding to systemic therapies has become an integral part of disease control. RECENT FINDINGS: Current efforts are focused on minimizing the morbidity of surgery (laparoscopic inguinal lymph node dissection, selective completion lymphadenectomy) as well as combining surgery with systemic therapy in novel ways (neoadjuvant targeted and/or immunotherapy, isolated limb infusion/perfusion with systemic immunotherapy ...
...NEW YORK Feb. 19 /- Delcath Systems Inc. ...(Logo: ...,Dr.,James,F.,Pingpank,to,Present,at,Leading,Regional,Therapies,Conference,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Regional Chemotherapy Technique for Extremity Sarcoma Salvages Patients Limbs from Amputation (March 16, 2017) Patients with a type of advanced malignant cancer of the arms or legs have typically faced amputation of the afflicted limb as the only treatment option. However, a technique that limits the application of chemotherapy to the cancerous region can preserve... Continue Reading. ...
Less than four days ago, a young Australian woman died of a very rare type of cancer. Most of my American and probably many of my European readers have never heard of her, but in Australia she had become quite famous over the last seven years as a major proponent of natural health. Her name was Jess Ainscough, but, like a certain.... ...
When treating confined melanoma regional perfusion therapy can be a treatment option for tumors that are confined to a single organ or region of the body.
2012-005748-12Resección D2 y HIPEC (quimioperfusión intraperitoneal hipertermica) en carcinoma gástrico localmente avanzado.Fundación Jiménez DíazInvest...
To meet the needs of patients, Canadian surgical and medical oncology leaders in the treatment of peritoneal surface malignancies (psms), together with patient representatives, formed the Canadian HIPEC Collaborative Group (chicg). The group is dedicated to standardizing and improving the treatment of psm in Canada so that access to treatment and, ultimately, the prognosis of Canadian patients with psm are improved.. Patients with resectable psm arising from colorectal or appendiceal neoplasms should be reviewed by a multidisciplinary team including surgeons and medical oncologists with experience in treating patients with psm. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy should be offered to appropriately selected patients and performed at experienced centres.. The aim of this publication is to present guidelines that we recommend be applied across the country for the treatment of psm.. ...
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an appropriate treatment for select patients with peritoneal carcinomat
A review of 60 consecutive patients with peritoneal carcinomatosis who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC)-sometimes called hot chemotherapy-found 0% mortality and 33% morbidity, with a significant reduction of grade III/IV morbidity, perioperative transfusion, and reintervention rate after 20 procedures. Reporting their results in the Archives of Surgery,1 physicians at the Institut Paoli-Calmettes and Université de la Méditerranée in Marseille, France, noted that the introduction of the HIPEC program was successful because of the surgical teams prior experience in cytoreductive and cancer operations.. Learning Curve. In an accompanying editorial, Nita Ahuja, MD, agreed: The message that we can heed here is that experience matters. In a follow-up interview with The ASCO Post, Dr. Ahuja said that there are cytoreduction-with-HIPEC programs with experienced physicians at several centers in the United States (see sidebar). These ...
U.S., April 14 -- ClinicalTrials.gov registry received information related to the study (NCT03111069) titled Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children on April 6. Brief Summary: The goal of this clinical research study is to find the highest tolerable dose of heated doxorubicin that can be given to patients during surgery with abdominal tumors. The safety of this drug will also be studied. Study Start Date: Study Type: Interventional Condition: Malignant Neoplasms of Mesothelial and Soft Tissue Rhabdomyosarcoma, Pelvic Rhabdomyosarcoma, Abdominal Intervention: Procedure: Abdominal Surgery Resectable Intra-Abdominal/Pelvic Tumors Group: Participants receive peritonectomy, omentectomy, cytoreduction, (complete surgical tumor resection, no gross residual disease). Unresectable Intra-Abdominal/Pelvic Tumors Group: ...
A recent Phase I clinical trial reported encouraging survival data with respect to the use of maximal cytoreduction combined with hyperthermic intraperitoneal chemotherapy (HIPEC) using pegylated liposomal doxorubicin (PLD)(e.g., Doxil™) to treat patients with advanced intra-abdominal, gastrointestinal and gynecological malignancies. HIPEC is used in conjunction with surgery and chemotherapy to treat patients with gastrointestinal tract…
Abstract: Advancements in medical technology coupled with a more thorough comprehension of oncologic diseases has resulted in a burgeoning number of aggressive treatment options available to cancer patients and a gradual loosening of the association between cancer and timely death. With the advent of extended life expectancies, however, the need to investigate the human and overall life impact of cancer diseases and treatments has increased dramatically (Langenhoff et al., 2001). This need to examine considerations of quality of life becomes even more essential in the context of high-risk treatments, such as cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS+HIPEC), an extensive procedure offered to select candidates with peritoneal carcinomatosis from a variety of primary origins (Levine et al., 2007). A biopsychosocial model of research and clinical care (e.g. Wilson & Cleary, 1995) underscores the many levels and interrelationships of clinical, demographic, and ...
HIPEC is an aggressive, novel surgical treatment reserved for patients with peritoneal carcinomatosis. It combines extensive removal of cancers, known as surgical cytoreduction, with the intraoperative introduction of chemotherapeutic drugs into the peritoneal cavity at a temperature several degress above normal body temperature. The abdominal cavity is perfused for about 90 minutes, thereby exposing potential microscopic residual cancer cells directly to the synergistic effects of hyperthermia (heat), and cytotoxic agents.. HIPEC is resource-intensive and requires extraordinary surgical and multidisciplinary cooperation. As such, only a few centers nationwide offer patients this option. The Feist-Weiller Cancer Center is the only cancer center in Louisiana that offers HIPEC presently.. HIPEC is used to treat the following types of cancers in its advanced and recurrent stages:. ...
Aims and objectives.To study patients descriptions of their health after cytoreductive surgery (CRS) before discharge.. Background. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) affects the patients recovery. The hospital stay is long, and it is important to study how patients experience their health postoperatively.. Design. Qualitative descriptive design.. Methods. Between January-May 2012, individual interviews were conducted with 20 patients in a university hospital in cen- tral Sweden using a semi-structured interview guide. Data were analysed using qualitative content analysis.. Results. Three themes (a process, body and mind, and support) and nine categories emerged. The surgery was described as a turning point, followed by a period of hope and thankfulness. Nevertheless, patients had difficulty taking in their positive feelings because they were overwhelmed by their bodily ailments. Despite the patients descriptions of being on an emotional roller ...
Discussion: The infection rate in our centre compared to previous studies of comparable patients was matching. Effective management of postoperative infections should be considered, and identified risk factors in this study can help to focus on effective prevention and treatment strategies. PMID: 31467552 [PubMed]...
The heated chemotherapy solution is continuously circulated throughout the abdominal cavity. So that the cavity is uniformly exposed to heat and chemotherapy. The combination of heat and chemotherapy causes the solution to kill microscopic cancer cells. Gentle shaking applied to the abdomen to help the solution distributed to all surfaces within the abdomen ...
TY - JOUR. T1 - A systematic review and meta-analysis of the randomized controlled trials on adjuvant intraperitoneal chemotherapy for resectable gastric cancer. AU - Yan, Tristan D.. AU - Black, Deborah. AU - Sugarbaker, Paul H.. AU - Zhu, Jacqui. AU - Yonemura, Yutaka. AU - Petrou, George. AU - Morris, David L.. PY - 2007/10. Y1 - 2007/10. N2 - Background: The purpose of this systematic review and meta-analysis was to determine the effectiveness and safety of adjuvant intraperitoneal chemotherapy for patients with locally advanced resectable gastric cancer. Methods: Studies eligible for this systematic review included those in which patients with gastric cancer were randomly assigned to receive surgery combined with intraperitoneal chemotherapy versus surgery without intraperitoneal chemotherapy. There were no language restrictions. After independent quality assessment and data extraction, data were pooled for meta-analysis. Results: Thirteen reports of randomized controlled trials (RCTs) were ...
Splenectomy is an independent risk factor for poorer perioperative outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: an analysis of 936 procedures
The imaging method called positron emission tomography (PET) using the radioactive tracer molecule 18F-FDG is a valuable way to both diagnose and track the progression of malignant peritoneal mesothelioma. Nuclear medicine researchers at a Hospital in Barcelona, Spain reviewed the diagnostic and treatment records of 60 people with malignant peritoneal mesothelioma, a form of mesothelioma that spreads on the membrane lining the walls of the abdomen. The study subjects included 34 women and 26 men with a mean age of 53. All the patients in the study had had multiple 18-F-FDG-PET scans to diagnose or track their cancer. Eleven of the studied patients had an FDG-PET scan prior to receiving treatment. In all cases, the scans showed characteristic mesothelioma disease … Continue reading Tracking Mesothelioma with FDG-PET » ...
SOUSA, Susana Marques de et al. Malignant Peritoneal Mesothelioma as a Rare Cause of Dyspeptic Complaints and Ascites: A Diagnostic Challenge. GE Port J Gastroenterol [online]. 2020, vol.27, n.3, pp.197-202. ISSN 2341-4545. http://dx.doi.org/10.1159/000503075.. Introduction: Malignant peritoneal mesothelioma (MPM) is a rare malignancy of the mesothelial cells in the peritoneum. The best-defined risk factor is asbestos exposure, but germline mutations in BAP1 also increase susceptibility to this tumor. The diagnosis of MPM is challenging since clinical manifestations are often nonspecific. Case Presentation: We describe a case of MPM in a 53-year-old former construction worker with prior asbestos exposure. The clinical presentation was a 3-month history of dyspeptic complaints. As initial workup, abdominal ultrasound and upper gastrointestinal endoscopy were performed. Chronic gastritis due to Helicobacter pylori was detected, which was promptly treated but without symptom relief. Abdominal ...
Define L-phenylalanine mustard. L-phenylalanine mustard synonyms, L-phenylalanine mustard pronunciation, L-phenylalanine mustard translation, English dictionary definition of L-phenylalanine mustard. n a drug, C13H18Cl2N2O2, used to treat myeloid leukaemia Noun 1. melphalan - antineoplastic drug used to treat multiple myeloma and some other malignancies...
Researchers at Roswell Park Cancer Institute (RPCI) have determined that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CS/HIPEC), a complex procedure to treat advanced abdominal cancers, can be done safely, and may be an effective therapy for select patients. Study results are published in the June issue of Cancer Medicine.
The SPRinT team sees patients with a wide spectrum of cancer types as peritoneal surface malignancies can arise from various organs. They can arise primarily from the peritoneum (e.g. mesothelioma, primary peritoneal cancer) or from the spread of a primary cancer (e.g. colorectal, appendix, stomach, ovary, hepatobiliary). Our team has extensive experience in treating these varieties of cancer from early to advanced stages. Previously regarded as fatal, peritoneal disease of all histological subtypes can now be successfully treated to achieve good outcomes for patients. Our multidisciplinary clinics offer a one-stop service for the evaluation and surgical management of these patients. In conjunction with our medical oncologists, we provide a comprehensive range of treatments for patients with peritoneal disease, including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The SPRinT team has been performing CRS and HIPEC since 2001 and currently, has one of the ...
The data were collected in the Medical Spectrum Twente, a large community teaching hospital in the regional capital of a foremost rural area in the eastern part of the Netherlands. It functions as a regional referral center for liver and lung surgery, but has no facilities for the treatment of peritoneal carcinomatosis with hyperthermic intraperitoneal chemotherapy (HIPEC).. The study design is a prospective observational cohort study evaluating the outcome of routine staging with abdominal CT concerning the ability to find liver metastases (LM), peritoneal carcinomatosis (PC) and T4-stage in colon cancer (LACC). All patients in our hospital who where treated for CRC from January 2007 till December 2009 were included in the analysis; all surgical patients with CRC in the study hospital were prospectively registered in a database designed for colorectal surgery, including patient characteristics, staging and surgical procedures, the clinical M stage and pathological TNM stage, post-operative ...
Feist-Weiller Cancer Center. View Dr. Chus CV. Dr. Quyen Chu is a Professor of Surgery and Chief of the Division of Surgical Oncology at LSUHSC at Shreveport. He joined LSUHSC at Shreveport in 2002 after completing a clinical fellowship in surgical oncology at Roswell Park Cancer Institute in Buffalo, NY.. Dr. Chus clinical interests include the management of patients with cancer of the gastrointestinal tract (esophagus, stomach, liver, bile ducts, pancreas, colon and rectum), breast cancer, melanoma, thyroid and parathyroid tumors, and soft tissue tumors (retroperitoneal tumors and extremity sarcomas). He has been instrumental in establishing two life-saving programs: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) program for advanced abdominal malignancies and mammosite for breast cancer patients. He has also helped in the development of novel therapies, such as gene therapy, to treat patients with advanced solid malignancies.. Dr. Chu has coauthored more than 70 publications and six book ...
BACKGROUND: While liver resection (LR) and cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) are commonly performed for
He also specializes in the treatment of peritoneal-based malignancies using hyperthermic intraperitoneal chemotherapy (HIPEC). Multidisciplinary GI Conference/Clinic. For patients with gastrointestinal cancers, we bring together a highly specialized team to rapidly evaluate each case and develop a consensus treatment plan. This is called a multidisciplinary conference. The purpose is to help speed up the time from diagnosis to treatment. This comprehensive conference includes surgeons, medical oncologists, radiation oncologists, pathologists, radiologists, a genetic counselor, clinical trials nurses, social workers, dietitians and a clinic coordinator.. Patients in the Multidisciplinary Gastrointestinal Oncology Clinic receive comprehensive therapy coordinated within a single clinic, resulting in the delivery of personalized clinical care. We also provide a caring and supportive environment with the help of our nursing staff, nurse practitioners, social workers and dietitians.. ...
Background: Pancreatic cancer is the fourth leading cause of cancer related death in the Western world. At time of diagnosis, 20% of patients present with a resectable tumour, 40% with an irresectable locally advanced tumor (without metastases) and 40% with metastatic disease. The median survival of patients with irresectable locally advanced pancreatic cancer is only 6 months. Currently, there is no effective treatment for these patients Importance: There is an urgent need for new therapeutical options in pancreatic adenocarcinoma. Radiofrequency ablation (RFA) is a technique that has been demonstrated to be effective in the treatment of several irresectable tumours such as liver and lung neoplasms. RFA produces local tumour destruction from an electrode implanted directly into the tumour causing frictional heating. Objective: To evaluate whether endoscopic ultrasound-guided radiofrequency ablation (EUSRFA) plus conventional treatment (chemotherapy ± radiotherapy) improves overall survival in ...
DUGi: Viewing Item from repository Recercat: Background: Pancreatic cancer is the fourth leading cause of cancer related death in the Western world. At time of diagnosis, 20% of patients present with a resectable tumour, 40% with an irresectable locally advanced tumor (without metastases) and 40% with metastatic disease. The median survival of patients with irresectable locally advanced pancreatic cancer is only 6 months. Currently, there is no effective treatment for these patients Importance: There is an urgent need for new therapeutical options in pancreatic adenocarcinoma. Radiofrequency ablation (RFA) is a technique that has been demonstrated to be effective in the treatment of several irresectable tumours such as liver and lung neoplasms. RFA produces local tumour destruction from an electrode implanted directly into the tumour causing frictional heating. Objective: To evaluate whether endoscopic ultrasound-guided radiofrequency ablation (EUSRFA) plus conventional treatment (chemotherapy ±
SPIS TREŚCI 2014, Tom XXXVI, Nr 216, CZERWIEC CONTENTS 2014, VOL XXXVI, No. 216, JUNE ARTYKUŁ REDAKCYJNY / EDITORIAL Chronowska J., Łabuzek K., Kukla U., Lekstan A., Okopień B.: 365 Dootrzewnowa chemioterapia perfuzyjna w hipertermii jako nowy sposób leczenia przerzutów nowotworowych do otrzewnej Hyperthermic intraperitoneal chemotherapy as a new way of peritoneal metastases treatment PRACE ORYGINALNE / ORIGINAL PAPERS Pawełczak E., Gaszyński T.: 369 Występowanie nadciśnienia tętniczego w społeczności miejskiej a promowanie zachowań prozdrowotnych The prevalence of hypertension among the urban community and promoting healthy behaviors Jerzykowska S., Cymerys M., Roszak M., Wysocka E., Michalak S., Pupek-Musialik D.: 373 Analiza wpływu krótkotrwałego wysiłku fizycznego na wybrane parametry funkcji śródbłonka naczyniowego oraz sztywność naczyń krwionośnych u młodych i zdrowych mężczyzn The analysis of the influence of short term physical effort on selected
Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for this treatment modality are lacking. Thirty-two patients (F/M ratio 12/20; median (range) age 58 (32-75) years) underwent CRS + HIPC with cisplatin for PC from gastric adenocarcinoma in 2010-2014. This monocentric phase-2 nonrandomized prospective study with a power of 90% aimed to improve the 1-year overall survival (OS) rate with 40% (historical reference of 52% to 72%). Median PCI score was 8 (range 1-20), number of regions involved was 6 (range 1-11). The impact of 16 prognostic factors on survival was evaluated using univariable and multivariable Cox regression models. Follow-up was complete in all patients, and closed 2 years after patient inclusion. All patients had complete cytoreduction (CCR-0) and histopathological R0 resection. PCI |/= 12 without PC on any small bowel region with 4 or
Intraperitoneal chemotherapy is beneficial and tolerable, and physicians should present it as an option to women who have had successful cytoreductive surgery for their advanced epithelial ovarian cancer.
Group 1 - During laparotomy, after tumor removal, patients receive continuous hyperthermic peritoneal perfusion (CHPP) with the anti-cancer drug cisplatin. For CHPP, the cisplatin solution is heated and delivered to the abdomen through a catheter (plastic tube), washed through the abdomen for 90 minutes, and then drained out of the body through another catheter. At the close of surgery, a small catheter, called a Tenckhoff catheter, is left in the abdomen and brought out through the skin. Between days 7 and 12 after surgery, one dose of fluorouracil and paclitaxel chemotherapy is delivered through this catheter. The catheter is removed following complete recovery from surgery and the patient is discharged from the hospital. Four to 6 weeks after the surgery, patients have CT scans of the chest, pelvis, and abdomen, and then begin intravenous (IV, through a vein) chemotherapy with oxaliplatin, 5-fluorouracil (5-FU), and leucovorin. The chemotherapy is given in 4-week courses as follows: ...
Intraperitoneal chemotherapy in the largest biology dictionary online. Free learning resources for students covering all major areas of biology.
Percutaneous hepatic perfusion (PHP) is a regionalized, minimally-invasive approach to cancer treatment currently undergoing Phase II and Phase III clinical testing. PHP treats a variety of hepatic tumors by isolating the liver and exposing the organ to high-dose chemotherapy. As demonstrated in clinical trials, patients treated by PHP can tolerate much higher doses of chemotherapeutic agents than those receiving traditional systemic chemotherapy without increased toxicities. Using a system of catheters and filters, PHP isolates the liver from the circulatory system and infuses a chemotherapeutic agent directly to the liver via the hepatic artery. The venous effluent from the liver is then filtered outside of the body and the filtered blood is returned into the jugular vein. PHP is a repeatable procedure and can be performed in an operating room or a radiology suite under local or general anesthesia. Delcath Systems Business Wire Delcath Systems, Inc. Pingpank JF, Libutti SK, Chang R, et al. ...
Peritoneal Carcinomatosis is a tumor spreading from its original site into the peritoneum (a membrane lining the abdominal cavity). Discover HIPEC
• Regional perfusion has been utilized in the treatment of accessible melanomas for many years. This series of 245 patients, which encompasses over ten years of
Cornelis J. H. van de Velde is the author of this article in the Journal of Visualized Experiments: Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Arian R. van Erkel is the author of this article in the Journal of Visualized Experiments: Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
ConclusionsComplete CRS and HIPEC can be achieved in strictly selected patient with unresectable PM at diagnosis after repeated PIPAC session with palliative intent....
Regional hyperthermia heats a larger part of the body, such as an entire organ or limb. Usually, the goal is to weaken cancer ... Hot chemotherapy drugs are pumped directly into the peritoneal cavity to kill the cancer cells. Whole-body hyperthermia heats ... This may use the same techniques as local hyperthermia treatment, or it may rely on blood perfusion. In blood perfusion, the ... It is typically used to treat metastatic cancer (cancer that spread to many parts of the body). Techniques include infrared ...
... chemotherapy, cancer, regional perfusion MeSH E04.292.451 --- extracorporeal membrane oxygenation MeSH E04.292.465 --- heart ...
... limb infusion is a minimally invasive alternative to isolated limb perfusion for delivering high-dose regional chemotherapy to ... 181m on cancer research grants in 2014, and almost 800 cancer patients per week still die of cancer, or over 40,000 Australians ... When local cancer tumours where injected with the vaccine, cancers that had not been injected began to shrink as well, thus ... innovative and specialist cancer drugs in Australia states that the five-year survival rate of patients with advanced cancer is ...
... (PHP) is a regionalized, minimally-invasive approach to cancer treatment currently undergoing ... PHP treats a variety of hepatic tumors by isolating the liver and exposing the organ to high-dose chemotherapy. As demonstrated ... Seidel GD, Locklin J, Muehlbauer PM (June 2006). "Part I: regional chematherapy clinical studies in nontraditional clinical ... treated by PHP can tolerate much higher doses of chemotherapeutic agents than those receiving traditional systemic chemotherapy ...
Seidel, Geoffrey D. Part I: Regional Chemotherapy Clinical Studies in Nontraditional Clinical Settings. 10.1188/06.CJON.338-344 ... as well as patients with melanoma who previously received isolated perfusion. Chemotherapy is usually delivered intravenously, ... New Jersey Providence Cancer Center in Portland, Oregon St. Luke's Cancer Center of Bethlehem, Pennsylvania Swedish Medical ... primary liver cancer and metastatic hepatic malignancies from neuroendocrine cancers and adenocarcinomas Pingpank, James F. ...
... is also used in veterinary medicine, where is it usually referred to as regional limb perfusion (RLP). It is ... Limb perfusion entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from ... The main purpose of the isolated limb perfusion technique is to deliver a very high dose of chemotherapy, at elevated ... Regional limb perfusion allows drug dose to be reduced while maintaining therapeutic concentrations at the site of interest, ...
"Intrathecal Chemotherapy for Cancer Treatment , CTCA". CancerCenter.com. Retrieved 22 May 2017. Hajdu SI (2003). "A note from ... This decreases total intracranial pressure and facilitates blood perfusion. Homeostasis: CSF allows for regulation of the ... "Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins". Science. ... Some anaesthetics and chemotherapy are injected intrathecally into the subarachnoid space, where they spread around the CSF, ...
... refractory cancer - regional cancer - regional chemotherapy - regional enteritis - regional lymph node - regional lymph node ... islet cell cancer - islet of Langerhans cell - isoflavone - isointense - isolated hepatic perfusion - isolated limb perfusion ... cancer induction - Cancer Information Service - cancer of unknown primary origin - Cancer stem cell - cancer vaccine - Cancer. ... local cancer - local therapy - localized gallbladder cancer - locally advanced cancer - lometrexol - lomustine - lonafarnib - ...
Coupled with imaging of cerebral perfusion, researchers can highlight regions of "perfusion/diffusion mismatch" that may ... TIRM is superior in the assessment of osteomyelitis and in suspected head and neck cancer. Osteomyelitis appears as high ... chemotherapy and celiac disease. Techniques to suppress fat on MRI mainly include: Identifying fat by the chemical shift of its ... "Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy". Magn ...
Another approach to cancer suppression is through the use of angiogenesis inhibitors to prevent the release of growth factors ... Microencapsulation is a valuable technique for local, regional and oral delivery of therapeutic products as it can be implanted ... 2003). "Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable ... which stimulate neovascularization and restore perfusion in the damaged ischemic heart. An example of this is shown in the ...
In case contrast agent has been used to mark the lesion, it will also drain into the regional lymph nodes, which then can be ... Improvements of the C-Arm technology nowadays also enable perfusion imaging and can visualize parenchymal blood volume in the ... 2003). "Performance Characteristics of Different Modalities for Diagnosis of Suspected Lung Cancer *". Chest. 123: 115S-128S. ... chemotherapy (curative approach) or through chemoembolization / ablation (palliative approach) A hybrid operating room supports ...
... as might occur following poisoning or cancer chemotherapy), exposure to ionizing radiation, or as a result of an infectious ... In children the presence of cyanosis, rapid breathing, poor peripheral perfusion, or a petechial rash increases the risk of a ... 8 (3). GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex ... Those who are weak, sick, malnourished, have cancer or are diabetic have increased susceptibility to chronic or persistent ...
The Regional Cancer Center. 2001 Archived October 7, 2009, at the Wayback Machine ... poor perfusion). Thus ischemia in a body part can cause localized anemic effects within those tissues. ... associated with chemotherapy, or associated with renal disease, some clinicians prescribe recombinant erythropoietin or epoetin ... Many type of cancers, including colorectal cancer and cancer of the urinary bladder, may cause acute or chronic blood loss, ...
... as might occur following poisoning or cancer chemotherapy), exposure to ionizing radiation, or as a result of an infectious ... In children the presence of cyanosis, rapid breathing, poor peripheral perfusion, or a petechial rash increases the risk of a ... "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a ... The patient is immunocompromised (for example, in AIDS or after chemotherapy);. *The infectious agent is of an uncommon nature ...
The prognosis of brain cancer depends on the type of cancer diagnosed. Medulloblastoma has a good prognosis with chemotherapy, ... Perfusion Weighted Imaging (PWI) and Diffusion Weighted Imaging (DWI) are two MRI techniques that reviews have been shown to be ... "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, ... "Cancer Stat Facts: Brain and Other Nervous System Cancer". National Cancer Institute. 31 March 2019.. ...
"Intrathecal Chemotherapy for Cancer Treatment , CTCA". CancerCenter.com. Retrieved 22 May 2017.. ... This decreases total intracranial pressure and facilitates blood perfusion.[1]. *Homeostasis: CSF allows for regulation of the ... Baricity refers to the density of a substance compared to the density of human cerebrospinal fluid and is used in regional ... Anaesthesia and chemotherapyEdit. See also: Blood-cerebrospinal fluid barrier. Some anaesthetics and chemotherapy are injected ...
Cancers may be treated by surgically removing the tumour, radiotherapy, chemotherapy or combinations thereof, or with the aim ... General anatomy: systems and organs, regional anatomy, planes and lines, superficial axial anatomy, superficial anatomy of ... Pulmonary emboli may be investigated using a ventilation/perfusion scan, a CT scan of the arteries of the lung, or blood tests ... The major risk factor for cancer is smoking. Once a cancer is identified it is staged using scans such as a CT scan and a ...
Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy. Proc Natl Acad Sci USA. 2007; ... of real-time optical spectroscopy to evaluate oxygenation and perfusion within melanoma lesions during regional chemotherapy. ... Hypoxia in Melanoma: Using Optical Spectroscopy and EF5 to Assess Tumor Oxygenation Before and During Regional Chemotherapy for ... Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy. ...
Isolated hepatic perfusion is a technique that can be used to deliver high doses of chemotherapy or biologic therapy regionally ... Regional treatment of the liver has the theoretic advantage of maximizing drug delivery while minimizing systemic toxicity. ... Study Design: Fifty patients with biopsy-proved unresectable primary or metastatic cancer to the liver were treated. Isolated ... Isolated hepatic perfusion is a technique that can be used to deliver high doses of chemotherapy or biologic therapy regionally ...
... cancer, regional perfusion. Chemotherapy, cancer, regional perfusion synonyms, Chemotherapy, cancer, regional perfusion ... cancer, regional perfusion translation, English dictionary definition of Chemotherapy, cancer, regional perfusion. n. 1. The ... treatment of cancer using specific chemical agents or drugs that are selectively destructive to malignant cells and tissues. 2 ... Chemotherapy, cancer, regional perfusion - definition of Chemotherapy, cancer, regional perfusion by The Free Dictionary https ...
Determination of Blood Volume and Its Application to Regional Perfusion in Chemotherapy Lead researcher. V C Marshall ... News from Cancer Council Victoria and stories of those affected by cancer. ... Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would ... Cancer is a disease of the cells, which are the bodys basic building blocks. ...
Cancer Treatment. Chemotherapy. Regional Therapy. Surgery. Additional relevant MeSH terms: Layout table for MeSH terms. ... The disease has a marked propensity for loco-regional spread and will be the sole or major site of disease in up to 80% of ... The disease has a marked propensity for loco-regional spread and will be the sole or major site of disease in up to 80% of ... Intraperitoneal chemotherapy in peritoneal malignancy: impact of intensive system care on practicability. Acta Med Austriaca. ...
Background In a prior randomized phase II trial comparing hyperthermic isolated limb perfusion (HILP) with four different doses ... Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148:616-32.CrossRefPubMedGoogle ... Systemic and haemodynamic toxicity after isolated limb perfusion (ILP) with TNF-alpha. J Exp Clin Cancer Res. 2004;23:225-31. ... European Organization for Research and Treatment of Cancer Institute of the United States, National Cancer Insitute of Canada. ...
Hyperthermic isolated limb perfusion with melphalan alone is administered as a double perfusion schedule. These two isolates ... CHEMOTHERAPY: At least 1 month since chemotherapy.. ENDOCRINE THERAPY: Not specified.. RADIOTHERAPY: At least 1 month since ... We are a Cancer Social Network, Resource Directory & Education Hub supporting all those affected by cancer. knowcancer.com is ... At least 2 months since any regional therapy to the affected extremity.. BIOLOGIC THERAPY: At least 1 month since Biologic ...
Chemohyperthermic peritoneal perfusion had an efficiency for the prophylaxis of recurrence after curative resection of advanced ... gastric cancer, and is indicated for patients with tumor infiltrating beyond serosal layer and node positive tumor. ... Chemotherapy, Adjuvant * Chemotherapy, Cancer, Regional Perfusion* * Female * Gastric Mucosa / pathology * Humans * Hypothermia ... Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized ...
Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148:616-31.PubMedGoogle Scholar ... Chemotherapy of sarcomas of the limbs by regional perfusion. Ann Surg. 1977;185:555-64PubMedGoogle Scholar ... Hyperthermic perfusion with chemotherapy for cancers of the extremities. Surg Gynecol Obstet. 1969;129:305-8.PubMedGoogle ... Results of regional isolation perfusion with cytostatics in patients with soft-tissue tumors of the extremities. Cancer. 1989; ...
86 Regional Chemotherapy for Liver Tumors 87 Systemic Chemotherapy for Hepatic Colorectal Cancer: Impact on Surgical Management ... 89 Isolated Hepatic Perfusion for Extensive Liver Cancer Subsection E Treatment: Resection 90A Hepatic Resection: General ... 49 Cancer of the Gallbladder 50A Cancer of the Bile Ducts: Intrahepatic Cholangiocarcinoma 50B Cancer of the Bile Ducts: ... 58A Epidemiology of Pancreatic Cancer. 58B Pancreatic Cancer: Clinical Aspects, Assessment, and Management 59 Pancreatic Cancer ...
Chemotherapy, Cancer, Regional Perfusion / methods* * Female * Gastrointestinal Neoplasms / pathology * Gastrointestinal ... Clin Cancer Res. 2015 Jul 15;21(14):3149-59. doi: 10.1158/1078-0432.CCR-14-1421. Epub 2015 Apr 7. ... a major cause of death in patients with gastrointestinal cancers, has yet to be achieved. We sought to test intrahepatic ...
Chemotherapy. Chemotherapy drugs stop cancer cell growth by either destroying the cells or stopping them from dividing. ... Isolated Limb Perfusion This very rarely used treatment directs a high dose of chemotherapy drugs directly to the soft tissue ... Regional Hyperthermia Therapy. This very rarely used treatment exposes the tissue around the tumor to high temperatures in ... Laryngeal Cancer Treatment Leukemia Treatment Lip & Oral Cavity Cancer Treatment Liver Cancer Treatment Lung Cancers Treatment ...
This is even lower in triple-negative breast cancer (TNBC) patients with concomitant lung... ... The median overall survival of metastatic breast cancer (MBC) patients is still approximately 2 years. ... Aigner KR, Guadagni S, Zavattieri G (2016) Regional chemotherapy for thoracic wall recurrence and metastasized breast cancer. ... Breast cancer Lung metastases Triple-negative status Isolated thoracic perfusion This is a preview of subscription content, log ...
Chemotherapy, Cancer, Regional Perfusion. *Laparoscopy. *Precancerous Conditions. *Gynecologic Surgical Procedures. * ... or Primary Peritoneal Cancer That Have Received at Least 2 Prior Lines of Chemotherapy ... Primary Peritoneal Cancer or Fallopian Tube Cancer Ovary. A Randomized, Open-label, Multicenter, Phase 3 Study To Evaluate The ... In Combination With And/or Following Chemotherapy In Patients With Previously Untreated Epithelial Ovarian Cancer ...
Chemotherapeutic Regional Perfusion. Chemotherapeutic regional perfusion (also called isolated limb perfusion) is a technique ... allowing your immune system to better attack the cancer cells, block the cancer cells from growing, or deliver chemotherapy or ... Skin cancer is cancer that starts in the skin cells. Skin cancers are divided into two major groups: *Nonmelanoma skin cancer, ... Skin cancer; Squamous cell cancer; Basal cell cancer; Actinic keratosis; Nonmelanoma skin cancer An in-depth report on the ...
Regional hyperthermia heats a larger part of the body, such as an entire organ or limb. Usually, the goal is to weaken cancer ... Hot chemotherapy drugs are pumped directly into the peritoneal cavity to kill the cancer cells. Whole-body hyperthermia heats ... This may use the same techniques as local hyperthermia treatment, or it may rely on blood perfusion. In blood perfusion, the ... It is typically used to treat metastatic cancer (cancer that spread to many parts of the body). Techniques include infrared ...
Target hepatic artery regional chemotherapy and bevacizumab perfusion in liver metastatic colorectal cancer after failure of ... Target hepatic artery regional chemotherapy and bevacizumab perfusion in liver metastatic colorectal cancer after failure of ... Target hepatic artery regional chemotherapy and bevacizumab perfusion in liver metastatic colorectal cancer after failure of ... Target hepatic artery regional chemotherapy and bevacizumab perfusion in liver metastatic colorectal cancer after failure of ...
Peritoneal Neoplasms; Hyperthermia, Induced; Chemotherapy, Cancer, Regional Perfusion; Adenocarcinoma; Antineoplastic Combined ... Lymphoma, Non-Hodgkin; Antineoplastic Combined Chemotherapy Protocols; Hemangiopericytoma; Meningioma; Antiretroviral Therapy, ...
Adolescent, Adult, Aged, Antineoplastic Agents/*administration & dosage, Chemotherapy; Cancer; Regional Perfusion, Humans, ... Primary tumors were pseudomyxoma peritonei (47 patients), colorectal cancer (38 patients), gastric cancer (6 patients), ovarian ... Depending on the primary tumor, mitomycin C or a platinum compound was used as a chemotherapeutic agent for perfusion. RESULTS ... BACKGROUND: Peritonectomy with heated intraperitoneal chemotherapy (HIPEC) has shown a survival benefit in selected patients ...
Chemotherapy, Cancer, Regional Perfusion. *Gastrointestinal Neoplasms. *Hyperthermia, Induced. *Peritoneal Neoplasms. *Surgical ... Wilkes - Wilkes Regional Medical Center. HPR- High Point Regional. N/A - Not applicable to services provided at facility and/or ... Wilkes - Wilkes Regional Medical Center. HPR- High Point Regional. N/A - Not applicable to services provided at facility and/or ... A Study of the Effects of Chemotherapy after Surgery in Breast Cancer Patients ...
Evidence-based recommendations on chemosaturation via percutaneous hepatic artery perfusion and hepatic vein isolation for ... Regional hepatic arterial delivery of high-dose chemotherapy with isolated hepatic perfusion used to be done using open ... Liver cancers Chemosaturation via percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic ... Treatment for primary or metastatic liver cancer depends on the location and stage of the cancer and how well liver function is ...
... methylation could be an important factor in determining which melanoma patients should receive melphalan regional chemotherapy. ... Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, ... Title: MGMT methylation correlates with melphalan pelvic perfusion survival in stage III melanoma patients: a pilot study. ... Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene ...
... study was to determine the effect of mild hyperthermia on tumor response and angioneogenesis in an isolated limb perfusion ... Creech OJ, Krementz ET, Ryan RF, Winblad JN: Chemotherapy of cancer: Regional perfusion utilizing an extracorporal circuit. Ann ... Prerequisites for effective isolated limb perfusion using tumor necrosis factor alpha and melphalan in rats. Br J Cancer. 1999 ... Cancer. 1992, 70: 2192-202.View ArticlePubMedGoogle Scholar. *. Ichihara F, Kono K, Sekikawa T, Matsumoto Y: Surgical stress ...
Isolated limb perfusion: A procedure that sends chemotherapy directly to an arm or leg in which the cancer has formed. The flow ... Regional chemotherapy Clinical trials are studying ways to improve the effect of chemotherapy on tumor cells, including the ... Chemotherapy Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells ... systemic chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated. ...
Locoregional chemotherapy via intra-arterial perfusion or chemoemoblization takes advantage of the increasing local drug ... Experimental: regional interventional chemotherapy group Procedure: regional interventional chemotherapy group The patients in ... Regional Versus Systemic Chemotherapy in the Treatment of Unresectable Pancreatic Cancer. The safety and scientific validity of ... Systemic chemotherapy with cytotoxic drug is of limited effectiveness in advanced pancreatic cancer patients. Gemcitabine has ...
But if there is no evidence of cancer in the sentinel node, patients are spared from additional lymph node surgery. ... In 1991, I introduced lymph-node mapping and sentinel lymph-node biopsy for melanoma and other selected skin cancers. Together ... If a biopsy of the sentinel node indicates cancer spread, the surrounding lymph nodes are removed. ... "Regional chemotherapy of melanoma." Brady MS, Coit DG. In: Regional Chemotherapy Clinical Research and Practice. Markman M, ed ...
Levine continues to research chemotherapy, cancer, regional perfusion, peritoneal neoplasms, and antineoplastic combined ... abdominal cancer, peritoneal carcinomatosis, hyperthermic intraperitoneal chemotherapy (HIPEC), colorectal cancer, sentinel ... esophageal tumors/cancer, peritoneal carcinomatosis, and gastrointestinal cancers. ... The Mesothelioma.com editorial team works hard to offer current, factual, expert reviewed information about mesothelioma cancer ...
Isolated limb perfusion: A procedure that sends chemotherapy directly to an arm or leg in which the cancer has formed. The flow ... Regional chemotherapy. Clinical trials are studying ways to improve the effect of chemotherapy on tumor cells, including the ... Chemotherapy. Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the ... systemic chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated. ...
SITE-DIRECTED CHEMOTHERAPY. • Direct instillation into sanctuary sites (intrathecal or peritoneal).. • Regional perfusion of ... Ovarian cancer, non-small cell and small cell lung cancer, breast cancer, head and neck cancer and bladder cancer. ... Major activity in head and neck cancer, small cell lung cancer, gastric cancer, advanced platinum- refractory ovarian cancer, ... Breast cancer, head and neck cancer, osteogenic sarcoma, bladder cancer, choriocarcinoma, primary central nervous system ...
Regional chemotherapy in the treatment of advanced pancreatic cancer--is it relevant?. Lorenz, M., Heinrich, S., Staib-Sebler, ... J. Cancer (2000) [Pubmed]. *Isolated hypoxic perfusion with mitomycin C in patients with advanced pancreatic cancer. Lorenz, M ... Regional chemotherapy. Lorenz, M., Heinrich, S. Hematol. Oncol. Clin. North Am. (2002) [Pubmed] ... Relevance of locoregional chemotherapy in patients with liver metastases from colorectal primaries. Lorenz, M., Heinrich, S., ...
Animals, Antineoplastic Agents/*administration & dosage, Chemotherapy, Cancer, Regional Perfusion/methods, Cytokines/genetics/* ... In an extremity perfusion model in tumor-bearing rats, we measured response rates to TNF therapy. RESULTS: Functional EMAP-II ... Results of the TNF perfusions in rats suggest that this tumor is more sensitive to TNF therapy. CONCLUSIONS: EMAP-II is ... Improved antitumor response to isolated limb perfusion with tumor necrosis factor after upregulation of endothelial monocyte- ...
... chemotherapy, cancer, regional perfusion MeSH E04.292.451 --- extracorporeal membrane oxygenation MeSH E04.292.465 --- heart ...