Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.
A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a corresponding reduction of another part of the same molecule. They include enzymes converting aldoses to ketoses (ALDOSE-KETOSE ISOMERASES), enzymes shifting a carbon-carbon double bond (CARBON-CARBON DOUBLE BOND ISOMERASES), and enzymes transposing S-S bonds (SULFUR-SULFUR BOND ISOMERASES). (From Enzyme Nomenclature, 1992) EC 5.3.
Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
Compounds in which one or more of the three hydroxyl groups of glycerol are in ethereal linkage with a saturated or unsaturated aliphatic alcohol; one or two of the hydroxyl groups of glycerol may be esterified. These compounds have been found in various animal tissue.
A group of alicyclic hydrocarbons with the general formula R-C5H9.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
CCR receptors with specificity for CHEMOKINE CCL17 and CHEMOKINE CCL22. They are expressed at high levels in T-LYMPHOCYTES; MAST CELLS; DENDRITIC CELLS; and NK CELLS.
CCR receptors with specificity for CHEMOKINE CCL1. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and MACROPHAGES.
A CC-type chemokine with specificity for CCR4 RECEPTORS. It has activity towards TH2 CELLS and TC2 CELLS.
The engulfment and degradation of cells by other cells.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Trihydroxy derivatives of eicosanoic acids. They are primarily derived from arachidonic acid, however eicosapentaenoic acid derivatives also exist. Many of them are naturally occurring mediators of immune regulation.
C22-unsaturated fatty acids found predominantly in FISH OILS.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
Commonly known as parasitic worms, this group includes the ACANTHOCEPHALA; NEMATODA; and PLATYHELMINTHS. Some authors consider certain species of LEECHES that can become temporarily parasitic as helminths.
Infestation with parasitic worms of the helminth class.
Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
A genus of nematode worms comprising the whipworms.
A situation in which the level of living of an individual, family, or group is below the standard of the community. It is often related to a specific income level.

Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. (1/152)

We have recently cloned eotaxin, a highly efficacious eosinophilic chemokine involved in the development of lung eosinophilia during allergic inflammatory reactions. To understand more precisely how eotaxin facilitates the specific migration of eosinophils, we have studied which adhesion receptors are essential for eotaxin action both in vivo and in vitro. Experiments using mice genetically deficient in adhesion receptors demonstrated that molecules previously reported to be involved in both leukocyte tethering/rolling (P-selectin and E-selectin) and in sticking/ transmigration (ICAM-1 and VCAM-1) are required for eotaxin action in vivo. To further elucidate the mechanism(s) involved in this process, we have used an in vitro transendothelial chemotaxis model. mAb neutralization studies performed in this system suggest that the integrins Mac-1 (CD11b/18), VLA-4 (alpha4beta1) and LFA-1 (CD11a/18) are involved in the transendothelial chemotaxis of eosinophils to eotaxin. Accordingly, the expression of these integrins on eosinophils is elevated by direct action of this chemokine in a concentration-dependent manner. Taken together, our results suggest that eotaxin-induced eosinophil transendothelial migration in vivo and in vitro relies on Mac-1/ICAM-1 and VLA-4NCAM-1 interactions, the latter ones becoming more relevant at later time points of the eotaxin-induced recruitment process.  (+info)

Eotaxin contributes to renal interstitial eosinophilia. (2/152)

BACKGROUND: A potent eosinophil chemotactic cytokine, human eotaxin, is directly chemotactic for eosinophils. Therefore, the specific expression of eotaxin in tissue might play a crucial role in tissue eosinophilia. However, the precise molecular mechanism of the recruitment and activation of eosinophils in human renal diseases remains to be investigated. We evaluated the role of eotaxin in the pathogenesis of human diffuse interstitial nephritis with marked infiltration of eosinophils. METHODS: In this study, we examined 20 healthy volunteers. 56 patients with primary or secondary glomerular diseases and two hypereosinophilic syndrome patients without renal involvement. Urinary and serum eotaxin levels were determined by an enzyme-linked immunosorbent assay. We also detected the presence of eotaxin protein immunohistochemically. RESULTS: On the one hand, urinary levels of eotaxin were significantly higher before the initiation of glucocorticoid administration in the patient with interstitial nephritis with marked infiltration of eosinophils. On the other hand, urinary eotaxin levels were not detected in any patients with nephrotic syndrome, interstitial nephritis without eosinophils, hypereosinophilic syndrome without renal involvement or other renal diseases. Serum eotaxin levels were not detected in any of the patients. Therefore, the detection of eotaxin in the urine was specific for renal interstitial eosinophilia. Moreover, endothelial cells, infiltrating mononuclear cells and renal epithelial cells in the tubulointerstitial lesions were immunostained with specific anti-eotaxin antibodies. Furthermore, the elevated urinary levels of eotaxin decreased dramatically during glucocorticoid-induced convalescence. HYPOTHESIS: We hypothesize that in situ expression of eotaxin may provide a new mechanism to explain the renal interstitial eosinophil infiltration.  (+info)

Differential chemokine expression in tissues involved by Hodgkin's disease: direct correlation of eotaxin expression and tissue eosinophilia. (3/152)

Hodgkin's disease (HD) is a lymphoid malignancy characterized by infrequent malignant cells surrounded by abundant inflammatory cells. In this study, we examined the potential contribution of chemokines to inflammatory cell recruitment in different subtypes of HD. Chemokines are small proteins that are active as chemoattractants and regulators of cell activation. We found that HD tissues generally express higher levels of interferon-gamma-inducible protein-10 (IP-10), Mig, RANTES, macrophage inflammatory protein-1alpha (MIP-1alpha), and eotaxin, but not macrophage-derived chemotactic factor (MDC), than tissues from lymphoid hyperplasia (LH). Within HD subtypes, expression of IP-10 and Mig was highest in the mixed cellularity (MC) subtype, whereas expression of eotaxin and MDC was highest in the nodular sclerosis (NS) subtype. A significant direct correlation was detected between evidence of Epstein-Barr virus (EBV) infection in the neoplastic cells and levels of expression of IP-10, RANTES, and MIP-1alpha. Levels of eotaxin expression correlated directly with the extent of tissue eosinophilia. By immunohistochemistry, IP-10, Mig, and eotaxin proteins localized in the malignant Reed-Sternberg (RS) cells and their variants, and to some surrounding inflammatory cells. Eotaxin was also detected in fibroblasts and smooth muscle cells of vessels. These results provide evidence of high level chemokine expression in HD tissues and suggest that chemokines may play an important role in the recruitment of inflammatory cell infiltrates into tissues involved by HD.  (+info)

Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4. (4/152)

The transmigration and adherence of T lymphocytes through microvascular endothelium are essential events for their recruitment into inflammatory sites. In the present study, we investigated the expression of CC chemokine receptor CCR3 on T lymphocytes and the capacities of the CC chemokine eotaxin to induce chemotaxis and adhesion in T lymphocytes. We have observed a novel phenomenon that IL-2 and IL-4 induce the expression of CCR3 on T lymphocytes. We also report that CC chemokine eotaxin is a potent chemoattractant for IL-2- and IL-4-stimulated T lymphocytes, but not for freshly isolated T lymphocytes. Eotaxin attracts T lymphocytes via CCR3, documented by the fact that anti-CCR3 mAb blocks eotaxin-mediated T lymphocyte chemotaxis. In combination with IL-2 and IL-4, eotaxin enhances the expression of adhesion molecules such as ICAM-1 and several integrins (CD29, CD49a, and CD49b) on T lymphocytes and thus promotes adhesion and aggregation of T lymphocytes. The eotaxin-induced T lymphocyte adhesion could be selectively blocked by a specific cAMP-dependent protein kinase inhibitor, H-89, indicating that eotaxin activates T lymphocytes via a special cAMP-signaling pathway. Our new findings all point toward the fact that eotaxin, in association with the Th1-derived cytokine IL-2 and the Th2-derived cytokine IL-4, is an important T lymphocyte activator, stimulating the directional migration, adhesion, accumulation, and recruitment of T lymphocytes, and paralleled the accumulation of eosinophils and basophils during the process of certain types of inflammation such as allergy.  (+info)

CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. (5/152)

Chemokines attract and activate distinct sets of leukocytes. The CC chemokine eotaxin has been characterized as an important mediator in allergic reactions because it selectively attracts eosinophils, Th2 lymphocytes, and basophils. Human eotaxin has a penultimate proline, indicating that it might be a substrate for dipeptidyl-peptidase IV (CD26/DPP IV). In this study we demonstrate that eotaxin is efficiently cleaved by CD26/DPP IV and that the NH2-terminal truncation affects its biological activity. CD26/DPP IV-truncated eotaxin(3-74) showed reduced chemotactic activity for eosinophils and impaired binding and signaling properties through the CC chemokine receptor 3. Moreover, eotaxin(3-74) desensitized calcium signaling and inhibited chemotaxis toward intact eotaxin. In addition, HIV-2 infection of CC chemokine receptor 3-transfected cells was inhibited to a similar extent by eotaxin and eotaxin(3-74). Thus, CD26/DPP IV differently regulates the chemotactic and antiviral potencies of eotaxin by the removal of two NH2-terminal residues. This physiological processing may be an important down-regulatory mechanism, limiting eotaxin-mediated inflammatory responses.  (+info)

Immunomodulatory role of C10 chemokine in a murine model of allergic bronchopulmonary aspergillosis. (6/152)

The immunomodulatory role of the chemokine C10 was explored in allergic airway responses during experimental allergic bronchopulmonary aspergillosis (ABPA). The intratracheal delivery of Asperigillus fumigatus Ag into A. fumigatus-sensitized mice resulted in significantly increased levels of C10 within the bronchoalveolar lavage, and these levels peaked at 48 h after A. fumigatus challenge. In addition, C10 levels in BAL samples were greater than 5-fold higher than levels of other chemokines such as monocyte-chemoattractant protein-1, eotaxin, and macrophage-inflammatory protein-1alpha. From in vitro studies, it was evident that major pulmonary sources of C10 may have included alveolar macrophages, lung fibroblasts, and vascular smooth muscle cells. Experimental ABPA was associated with severe peribronchial eosinophilia, bronchial hyperresponsiveness, and augmented IL-13 and IgE levels. The immunoneutralization of C10 with polyclonal anti-C10 antiserum 2 h before the intratracheal A. fumigatus challenge significantly reduced the airway inflammation and hyperresponsiveness in this model of ABPA, but had no effect on IL-10 nor IgE levels. Taken together, these data suggest that C10 has a unique role in the progression of experimental ABPA.  (+info)

Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of alpha4 integrins and vascular cell adhesion molecule-1. (7/152)

Eotaxin is a potent eosinophil-specific CC-chemokine, which has been shown to play a role in the selective induction of eosinophil accumulation in a number of allergic models of inflammation. Many aspects of the mechanism by which eotaxin induces eosinophil accumulation in vivo remain unresolved. In the present study, we investigated the direct effect of synthetic human eotaxin on leucocyte/endothelial cell interactions within rat mesenteric venules, as quantified by intravital microscopy. Topical eotaxin (30 pmol) induced rapid firm adhesion and extravasation of leucocytes within the rat mesentery, the extravasated leucocytes all being eosinophils, as determined by histological analysis. Whilst eotaxin was unable to stimulate the interaction of rat eosinophils with vascular cell adhesion molecule-1 (VCAM-1) under static conditions in vitro, eotaxin-induced responses in vivo were significantly suppressed by anti-alpha4 integrin and anti-VCAM-1 monoclonal antibodies (mAbs). The anti-alpha4 integrin mAb, HP2/1 (3.5 mg/kg), inhibited the eotaxin-induced firm adhesion and extravasation, 60 min postapplication of the chemokine, by 89% and 84%, respectively. In the same set of experiments, the anti-VCAM-1 mAb, 5F10 (3.5 mg/kg), inhibited leucocyte adhesion and extravasation by 61% and 63%, respectively. These results demonstrate that eotaxin-induced migration of eosinophils through rat mesenteric venules in vivo is dependent on an alpha4 integrin/VCAM-1 adhesion pathway, the significance of which may only be evident under flow conditions and/or following the ligation of other adhesion molecules expressed on eosinophils.  (+info)

Human thymocytes express CCR-3 and are activated by eotaxin. (8/152)

Eotaxin has been characterized as a chemokine involved in eosinophil activation; however, mRNA for this C-C chemokine has been shown to be constitutively expressed in thymus. Immunohistochemical analysis showed a punctate distribution pattern, with eotaxin expression localized mainly in the medulla and in Hassle's corpuscles. Moreover, the receptor for eotaxin, CCR-3, was detected on thymocytes, with the highest level of expression being on the CD8 single-positive population. Equilibrium binding analyses on unfractionated thymocytes demonstrated specific 125I-eotaxin binding profiles comparable with CCR-3 transfectants. Eotaxin induced cell migration and mobilization of intracellular calcium in all thymocytes except the immature CD4(-)/CD8(-) population. Eotaxin also induced the secretion of the chemokines interleukin-8, RANTES, and macrophage inflammatory protein-1beta from thymocyte cultures in vitro. These results suggest that eotaxin-induced thymocyte activation may have important physiological implications for lymphocyte mobilization within and from this lymphoid organ.  (+info)

Definition of Eosinophil Chemotactic Factor in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Eosinophil Chemotactic Factor? Meaning of Eosinophil Chemotactic Factor as a finance term. What does Eosinophil Chemotactic Factor mean in finance?
Looking for eosinophil chemotactic factor? Find out information about eosinophil chemotactic factor. A peptide released from mast cell granules that stimulates chemotaxis of eosinophils; may be responsible for accumulation of eosinophils at sites of... Explanation of eosinophil chemotactic factor
Eosinophil chemotactic factor of anaphylaxis definition at, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
Im doing a project for my cell class (sorry if this is in the wrong forum--I couldnt find a homework forum) about the eosinophil chemotactic factor. I was wondering if someone could point me in the right direction for a few answers. My professor seemed to think everything could be found online and I dont doubt him, Im just getting conflicting answers. Heres what I have so far ...
References for Abcams Recombinant human Eotaxin 2 protein (ab54405). Please let us know if you have used this product in your publication
Eotaxin His Tag Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids fragment (24-87).
Arachidonic acid (AA) is converted to a large number of biologically active products by cyclooxygenases, lipoxygenases, and cytochrome P450 enzymes (Funk,
Patients with asthma demonstrate circadian variations in the airway inflammation and lung function. Pinealectomy reduces the total inflammatory cell number in the asthmatic rat lung. We hypothesize that melatonin, a circadian rhythm regulator, may modulate the circadian inflammatory variations in asthma by stimulating the chemotaxins expression in the lung epithelial cell. Lung epithelial cells (A549) were stimulated with melatonin in the presence or absence of TNF-α(100 ng/ml). RANTES (Regulated on Activation Normal T-cells Expressed and Secreted) and eotaxin expression were measured using ELISA and real-time RT-PCR, eosinophil chemotactic activity (ECA) released by A549 was measured by eosinophil chemotaxis assay. TNF-α increased the expression of RANTES (307.84 ± 33.56 versus 207.64 ± 31.27 pg/ml of control, p = 0.025) and eotaxin (108.97 ± 10.87 versus 54.00 ± 5.29 pg/ml of control, p = 0.041). Melatonin(10-10 to 10-6M) alone didnt change the expression of RNATES (204.97 ± 32.56 pg/ml) and
Eotaxin Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8403.2 Dalton.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Expression of pulmonary eotaxin protein and mRNA was determined in six subjects with atopic asthma and five nonatopic normal subjects. Levels of eotaxin expression and eosinophil mobilization were compared before and after segmental allergen challenge in subjects with atopic asthma. In the absence o …
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online on January 4, 2006 in the Journal of Clinical Investigation, including: Soy diet worsens heart disease; Breast cancer-causing gene predicts shorter survival; Blocking eotaxin may help asthmatics breathe easier; Turns-ons and turn-offs for smooth muscle cells; Cancer detection: spinning biological trash into diagnostic gold; How chromosomal leap frog causes cancer in B cells; and others.
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Previous investigations have demonstrated a link between elevated levels of eosinophils, eosinophil activation, and adult IBD. However, there have been conflicting data regarding the individual contribution of the eosinophil-selective chemokines eotaxin-1 and eotaxin-2 in eosinophil recruitment in IBD. In the present study we demonstrate the following: 1) that eosinophil numbers are elevated in pediatric UC and that their level correlates with disease severity; 2) eotaxin-1 and not eotaxin-2 or eotaxin-3 is up-regulated in lesional colonic biopsy samples of pediatric UC patients; and 3) eotaxin-1 mRNA expression correlates with colonic eosinophil levels in pediatric UC. Using a chemical-induced colonic injury model, we define that eotaxin-1, and not eotaxin-2, is critical for eosinophil recruitment and that eotaxin-1 is predominantly derived from intestinal macrophages. Consistent with our experimental analysis, we show that eotaxin-1 is predominantly expressed by intestinal macrophages; ...
Subjects admitted on this protocol will have elevated eosinophil counts in the peripheral blood or tissues or will be relatives of subjects with eosinophilia. Eosinophilic subjects will undergo an extensive clinical evaluation focused on the identification of the cause of eosinophilia and the presence of end organ manifestations. In addition, they will be characterized in detail immunologically, and their blood cells and/or serum will be collected to provide reagents (eg. specific antibodies, T-cell clones, etc.) that will be used in the laboratory to address broader questions relating to the etiology of eosinophilia, its immunoregulation, the degree and source of eosinophil activation, and/or the functional role of eosinophils in the afferent arm of those immune response where they are prominent. While the protocol is not primarily designed to study treatment of patients with blood and tissue eosinophilia, the clinical and immunological responses to various medically indicated therapies will be ...
We have characterized previously the expression of the chemokines eotaxin, MCP-5, RANTES, and MCP-1 (mRNA and/or protein), and correlated this with the leukocytes migrating to the lung during a murine model of lung inflammation ((5), (16)). From these experiments, we concluded that MCP-1 mRNA expression paralleled the accumulation of monocytes/macrophages in this organ, both events occurring predominantly at early stages of the response (day 15). Also, eotaxin mRNA expression paralleled lung eosinophilia predominantly at late stages (day 21). In contrast, other chemokines, such as RANTES or MCP-5, were expressed throughout the inflammatory reaction. This underlines the contribution of chemokines at different stages of the response.. From the work presented here, we first conclude that eosinophil recruitment and development of BHR in this model system involve the action of both eosinophilic (eotaxin, RANTES, MCP-5, and MIP-1α) and noneosinophilic chemokines (MCP-1). This indicates the absence of ...
Eosinophils are specialized myeloid cells associated with allergy and helminth infections. Blood eosinophils demonstrate circadian cycling, as described over 80 years ago, and are abundant in the healthy gastrointestinal tract. Although a cytokine, interleukin (IL)-5, and chemokines such as eotaxins mediate eosinophil development and survival, and tissue recruitment, respectively, the processes underlying the basal regulation of these signals remain unknown. Here we show that serum IL-5 levels are maintained by long-lived type 2 innate lymphoid cells (ILC2) resident in peripheral tissues. ILC2 cells secrete IL-5 constitutively and are induced to co-express IL-13 during type 2 inflammation, resulting in localized eotaxin production and eosinophil accumulation. In the small intestine where eosinophils and eotaxin are constitutive, ILC2 cells co-express IL-5 and IL-13; this co-expression is enhanced after caloric intake. The circadian synchronizer vasoactive intestinal peptide also stimulates ILC2 cells
What, then, are those secret ingredients in blood that age the brain? According to Sakura Minami of the San Carlos-based biotech company Alkahest, one is eotaxin, a ligand for the C-C chemokine receptor type 3 (CCR3). Using proteomics approaches, Minami and colleagues saw that eotaxin shot up in the blood with age. Also known as CCL11, eotaxin is known to play a role in inflammation, for example in the recruitment of eosinophils upon CCR3 engagement. Given that these infection-fighting white blood cells can become damaging in allergic conditions such as asthma, CCR3 is an established drug target.. The researchers previously demonstrated that injecting eotaxin into young mice caused neurogenesis in the dentate gyrus to slow to a trickle, and that neutralizing eotaxin with an antibody blocked this effect (Aug 2011 news). At SfN, Minami reported preclinical findings from efforts to stifle the consequences of age-related eotaxin elevation. Rather than target eotaxin directly, Alkahest scientists ...
The eosinophil is an enigmatic cell with a continuing ability to fascinate. In this book, experts in the field of eosinophil biology comprehensively update our knowledge on the human eosinophil in health and disease. Topics discussed include a synopsis of eosinophil characteristics, properties and role in disease. Important information on how eosinophils release their potent and toxic granule proteins will be covered and how these basic proteins give rise to pathologies including issues such as the function of the nerves. (Imprint: Nova Biomedical ...
Hi Again Please could you tell me what tissue in mouse is a good positive control for eosinophil staining. Thanks Marilyn _______________________________________________ Histonet mailing list [email protected] ...
Below is a list of some of the research published this year that focus on eosinophil associated diseases. This is not an exhaustive list by any means, however,
If for any reason you are not completely happy with your purchase, dont worry! You have 60 days to let us know for a full refund ...
Of the three types of leukocytes recruited, neutrophils, eosinophils, and macrophages, the most striking difference between BLTR−/− and wild-type mice occurred in eosinophil recruitment (Fig. 5 A). Neither group had substantial numbers of peritoneal eosinophils at baseline or 4 h after thioglycollate instillation. Peak numbers of eosinophils were seen in both groups at 48 h, but BLTR−/− mice recruited only 33% as many eosinophils to the inflamed peritoneum as wild-type mice at this time point (P , 0.005). Numbers of peritoneal eosinophils declined in both groups at 96 h, but BLTR−/− mice continued to have significantly fewer of these cells. At 96 h, BLTR−/− mice had only 20% as many eosinophils recovered from the peritoneal cavity as wild-type mice (P , 0.01).. Although the numbers of peritoneal neutrophils and macrophages appeared lower in the BLTR−/− mice at some time points, the differences from wild type did not reach statistical significance for either of these cell ...
TY - JOUR. T1 - Interleukin-12 inhibits eotaxin secretion of cultured primary lung cells and alleviates airway inflammation in vivo. AU - Ye, Yi Ling. AU - Huang, Wan Ching. AU - Lee, Yueh L.. AU - Chiang, Bor Luen. PY - 2002. Y1 - 2002. N2 - The mechanisms that cause the inflammation of airway and lung tissue in asthma have been studied extensively. It is noted that type 1 T helper cell (Th1)-related cytokines could decrease the accumulation of eosinophils in lung tissue and relieve airway constriction. But the therapeutic mechanisms of Th1 cytokines remain unclear. In this study, interleukin-12 (IL-12) DNA plasmid as a therapeutic reagent was delivered intravenously. Bronchoalveolar lavage (BAL) fluids were collected from IL-12 treated and control mice, and analyzed for cell composition and eotaxin level. The results showed that IL-12 DNA plasmid could effectively inhibit eosinophilia and airway inflammation in vivo. The level of eotaxin in BAL fluid also decreased. To further investigate the ...
Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated
TY - JOUR. T1 - The surface phenotype of human eosinophils. AU - Tachimoto, Hiroshi. AU - Bochner, Bruce S.. PY - 2000/3/16. Y1 - 2000/3/16. UR - UR - M3 - Review article. C2 - 10761304. AN - SCOPUS:0034094643. VL - 76. SP - 45. EP - 62. JO - Progress in Allergy. JF - Progress in Allergy. SN - 1660-2242. ER - ...
Eosinophils play a key role in the pathogenesis of asthma, and T cells are controller cells in the recruitment and activation of eosinophils.
An acceptable eosinophil range is 30 to 350 in an absolute blood count, Medscape claims. Someone who has more than 500 eosinophils per microliter of blood
Cinqair (formerly Cinquil) (Reslizumab) is being studied to treat eosinophil disorders. Cinqair (Reslizumab) could possibly be used for eosinophilic asthma and esophagitits.
Join from a PC, Mac, iPad, iPhone or Android device: Please click this URL to join. Passcode: 678690 Or One tap mobile: +13017158592,,81649160184# US (Washington DC) +13126266799,,81649160184# US (Chicago) Or join by phone: Dial(for higher quality, dial a number based on your current location): US: +1 301 715 8592 or +1 312 626 6799 or +1 929 205 6099 or +1 253 215 8782 or +1 346 248 7799 or +1 669 900 6833 Webinar ID: 816 4916 0184 International numbers available: ...
Asthma is associated with eosinophilic airway inflammation and eosinophils are believed to be important in the pathogenesis of asthma. IL-5 has been considered the central mediator for eosinophilic proliferation, differentiation and eosinophilic inflammation, but results of recent studies suggest that besides IL-5, eotaxin may contribute to the pathogenesis of asthma. Eotaxin is CC chemokine first isolated from guinea pig bronchoalveolar lavage. It selectively binds to a specific receptor (CCR3) highly expressed on eosinophils, basophils, and mast cells being important in the pathogenesis of asthma. Eotaxin is produced mainly by epithelial cells of lung and gut, to mediate organ preferential attraction of eosinophils. Production of eotaxin is stimulated by IL-4, IL-13, TNF-α. Human eotaxin family includes: eotaxin-1 (CCL11), eotaxin-2 (CCL24) and eotaxin-3 (CCL26). It seems that eotaxin-3 may be expressed following allergen challenge. Studies with glucocorticosteroids have shown some inhibitory ...
TY - JOUR. T1 - Failure of sputum eosinophilia after eotaxin inhalation in asthma. AU - Bumbacea, D.. AU - Scheerens, J.. AU - Mann, B. S.. AU - Stirling, R. G.. AU - Chung, K. F.. PY - 2004/5. Y1 - 2004/5. N2 - Background: Eotaxin is a chemokine specific for eosinophils and may play an important role in eosinophil recruitment in asthma. The effects of eotaxin inhalation on sputum and blood eosinophils, exhaled nitric oxide (NO), and bronchial responsiveness were determined. Methods: Eotaxin was administered by nebulisation to asthma patients in three studies: (1) an open dose finding study with eotaxin (5, 10 and 20 μg) to two asthmatic subjects; (2) a randomised placebo controlled study with 20 μg eotaxin to five asthmatic subjects and five normal volunteers; and (3) a randomised placebo controlled study with 40 μg eotaxin to nine asthmatics. Forced expiratory volume in 1 second (FEV 1), exhaled NO, and blood eosinophils were measured before and hourly for 5 hours after nebulisation and at ...
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Eosinophilia (e-o-sin-o-FILL-e-uh) is a higher than normal level of eosinophils. Eosinophils are a type of disease-fighting white blood cell. This condition most often indicates a parasitic infection, an allergic reaction or cancer.. You can have high levels of eosinophils in your blood (blood eosinophilia) or in tissues at the site of an infection or inflammation (tissue eosinophilia).. Tissue eosinophilia may be found in samples taken during an exploratory procedure or in samples of certain fluids, such as mucus released from nasal tissues. If you have tissue eosinophilia, the level of eosinophils in your bloodstream is likely normal.. Blood eosinophilia may be detected with a blood test, usually as part of a complete blood count. A count of more than 500 eosinophils per microliter of blood is generally considered eosinophilia in adults. A count of more than 1,500 eosinophils per microliter of blood that lasts for several months is called hypereosinophilia.. Eosinophils play two roles in your ...
The current presence of eosinophils in the lung is often seen as a defining feature of asthma. through rules of eosinophil progenitor creation. A nationwide study found that over fifty percent (54.6%) from the U.S. human population test positive to 1 or more things that trigger allergies.1 Allergic asthma is a chronic inflammatory disease thats seen as a eosinophil infiltration. Eosinophils are prominent effector cells Rabbit polyclonal to CD105 in sensitive asthma.2C4 Several research established a causative web page link between eosinophils and allergic lung illnesses.5C8 Targeting eosinophils using anti-IL-5 antibodies continues to be regarded as a therapeutic approach for the treating asthma. In stable condition, eosinophil progenitors continuously egress from your bone marrow in to the bloodstream and circulate to peripheral cells. In sensitive diseases, the bone tissue marrow releases improved amounts of eosinophil progenitor cells that migrate to the website of sensitive inflammation, ...
Eosinophil accumulation is a distinctive feature of lung allergic inflammation. Here, we have used a mouse model of OVA (ovalbumin)-induced pulmonary eosinophilia to study the cellular and molecular mechanisms for this selective recruitment of eosinophils to the airways. In this model there was an early accumulation of infiltrating monocytes/macrophages in the lung during the OVA treatment, whereas the increase in infiltrating T-lymphocytes paralleled the accumulation of eosinophils. The kinetics of accumulation of these three leukocyte subtypes correlated with the levels of mRNA expression of the chemokines monocyte chemotactic peptide-1/JE, eotaxin, and RANTES (regulated upon activation in normal T cells expressed and secreted), suggesting their involvement in the recruitment of these leukocytes. Furthermore, blockade of eotaxin with specific antibodies in vivo reduced the accumulation of eosinophils in the lung in response to OVA by half. Mature CD4+ T-lymphocytes were absolutely required for ...
Eosinophils are major effector cells in type 2 inflammatory responses and become activated in response to IL-4 and IL-33, yet the molecular mechanism remains unclear. We examined the direct effect of these cytokines on eosinophils and demonstrated that murine eosinophils respond to IL-4 and IL-33 by phosphorylation of STAT-6 and NFkB, respectively. RNA sequencing analysis of murine eosinophils indicated that IL-33 regulates 519 genes, whereas IL-4 regulates only 28 genes, including 19 IL-33-regulated genes. Interestingly, IL-33 induced eosinophil activation via two distinct mechanisms, IL-4 independent and IL-4 secretion/auto-stimulation dependent. Anti-IL-4 or anti-IL-4Ra antibody-treated eosinophils, as well as Il4- or Stat6-deficient eosinophils, had attenuated protein secretion of a subset of IL-33-induced genes, including Retnla and Ccl17. However, the induction of most IL-33-regulated transcripts (e.g. Il6 and Il13) was IL-4 independent and blocked by NFkB inhibition. Indeed, IL-33 induced the
Eosinophil, coloured scanning electron micrograph (SEM). This eosinophil is from a patient with eosinophilic cellulitis (Wells syndrome), a type of inflammatory dermatitis. Eosinophils are a white blood cell involved in the immune response to antigens (fragments on the surface of pathogens or foreign objects). Magnification: x8000 when printed at 10 centimetres wide. - Stock Image C020/8235
EzWay Mouse Eotaxin ELISA Kit,K1332181,Cytokine ELISA Kit,EzWay Cytokine ELISA Kit reduces your assay time to 2.5 hours by integrating incubation of sample & …
An interactive resource tool for Eosinophil Cell Markers that includes a brief background on Eosinophil Cell Markers and links to related antibodies.
Number of eosinophils in lung tissue from immunized wild-type and γ/δ T cell- deficient animals receiving seven exposures with OVA or SAL. Solid bars, mea
இயோசிநாடிகள் அல்லது இயோசினேற்பிகள் அல்லது இயோசினாஃபில்கள் (Eosinophils) என்று இவை அழைக்கப்படுகின்றது. 0.5-3.0% வெள்ளையணுக்கள் இவ்வகை சார்ந்தவை . இவை நகரும் இயல்புடையவை. உடல் உறுப்புகளின் திசுக்களில் வீக்கம் ஏற்படின் இவை அங்கு நகர்ந்து செல்கின்றன. ஒவ்வாமைத் தன்மையில் (Allergy) இவற்றின் எண்ணிக்கை அதிகரிக்கும். இவை நோய் எதிர்ப்பாற்றல் முறைமையில் முக்கிய பங்களிக்கும். பலகல ஒட்டுண்ணிகள் ...
Background: MCP-1 (CCL2), MCP-3 (CCL7), and eotaxin (CCL11) are genes for CC chemokines clustered on the long arm of chromosome 17. Previous studies have implicated these chemokines in monocyte recruitment, viral replication, and anti-HIV cytotoxic T cell responses. An epidemiological analysis identified genetic variants influencing HIV-1 transmission and disease progression. Methods: Genomic DNA from over 3000 participants enrolled in five natural history cohorts in the United States were analyzed. Nine single nucleotide polymorphisms (SNP) covering 33 kb containing these three genes were genotyped using the polymerase chain reaction. Distortions in allele, genotype, and haplotype frequencies were assessed with respect to HIV-1 transmission and rates of disease progression using categorical and survival analyses. Results: Extensive linkage disequilibrium was observed. Three SNP (−2136T located in theMCP-1 promoter region, 767G in intron 1 of MCP-1, and −1385A in the Eotaxin promoter) were nearly
TY - JOUR. T1 - Human eosinophils: Their accumulation, activation and fate. AU - Walsh, Garry Michael. PY - 1997/6. Y1 - 1997/6. KW - eosinophils. KW - adhesion. KW - activation. KW - mediators. KW - apoptosis. KW - CELL-ADHESION MOLECULE-1. KW - COLONY-STIMULATING FACTOR. KW - ENDOTHELIAL-CELLS. KW - IN-VIVO. KW - INCREASED EXPRESSION. KW - BRONCHIAL-MUCOSA. KW - 3T3 FIBROBLASTS. KW - LYMPHOCYTES-T. KW - ASTHMA. KW - FIBRONECTIN. M3 - Literature review. VL - 97. SP - 701. EP - 709. JO - British Journal of Haematology. JF - British Journal of Haematology. SN - 0007-1048. IS - 4. ER - ...
Date: Friday, October 26, 2007 16:09 Subject: [Histonet] Eosinophil Staining To: [email protected] > I am looking to do a comparative staining study on eosinophils (tissue > is in FFPE). Among several stains, I plan to include a > hematoxylin/eosin/azure II stain which will stain eosinophils pink > (Friend et al. 2000) and a Sirius red stain (Aust et al. 2000). > Unfortunately, for the H&E/azure II stain, no publications give the > protocol or specific stain sequence. As for the Sirius red > stain, the > study states that the authors bought the stain from Bayer AG in > Germany.I have contacted Bayer and no one seems to know what I > am talking about. > Before I substitute the Bayer Sirius red, I want to make sure that > using another companys stain is appropriate as the protocol is > described as Sirius red (500mg) was dissolved in 45 ml aqua > bidest, 50 > ml absolute ethanol and 1 ml 1% NaOH; 4ml NaCl at 20% solution > was added > until slight precipitation occurred. My ...
An eosinophil count is a type of blood test that measures the quantity of eosinophils in your body. An eosinophil is a type of white blood cell.
An eosinophil count is a type of blood test that measures the quantity of eosinophils in your body. An eosinophil is a type of white blood cell.
The respective life histories of human subjects and mice are well defined and describe a unique story of evolutionary conservation extending from sequence identity within the genome to the underpinnings of biochemical, cellular, and physiologic pathways. As a consequence, the hematopoietic lineages …
Defective eosinophil chemotaxis to eotaxin in a patient with chronic lower baseline cD4+ T-lymphocytes and elevated CD8+ T cells Amr E El-Shazly1, Monique Henket2, Philippe P Lefebvre1, Renaud Louis21Department of Oto-Rhino-Laryngology and Head and Neck Surgery, GIGA-Research, Liege University Hospitals (Centre Hospitalier Universaitaire-C.H.U.). Liege-Belgium; 2Department of Pulmonology, GIGA-Research, Liege University Hospitals (Centre Hospitalier Universaitaire-C.H.U.). Liege-BelgiumBackground: Idiopathic selective CD4+ lower baseline cell count and an increase in CD8+ cells is an unusual immune defect. Whether this is a true variant of idiopathic CD4+ T lymphocytopenia (ICL) or a sequelae to recurrent infections is not clear.Objectives: The primary objective of this study was to investigate the expression and function of the cc-chemokine receptor CCR3 in eosinophils from a female patient with this disorder. A secondary objective was to study the in vitro ability of different cytokines to modulate
Define macrophage chemotactic factor (MCF). macrophage chemotactic factor (MCF) synonyms, macrophage chemotactic factor (MCF) pronunciation, macrophage chemotactic factor (MCF) translation, English dictionary definition of macrophage chemotactic factor (MCF). n. Any of various large, phagocytic white blood cells that develop from monocytes, are found in the spleen, liver, and other tissues, and have a variety of...
The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo ...
TY - JOUR. T1 - Assessment of eosinophils in gastrointestinal inflammatory disease of dogs. AU - Bastan, Idil. AU - Rendahl, Aaron. AU - Seelig, David AU - Day, Michael. AU - Hall, Edward. AU - Rao, Savita. AU - Washabau, Robert. AU - Sriramarao, P. PY - 2018/11/1. Y1 - 2018/11/1. N2 - BackgroundAccurate identification of eosinophils in the gastrointestinal (GI) tract of dogs with eosinophilic GI disease (EGID) by histological evaluation is challenging. The currently used hematoxylin and eosin (H&E) staining method detects intact eosinophils but does not detect degranulated eosinophils, thus potentially underrepresenting the number of infiltrating eosinophils.ObjectiveTo develop a more sensitive method for identifying and quantifying both intact and degranulated eosinophils to diagnose EGID more accurately.MethodsEndoscopically obtained paraffin‐embedded intestinal biopsy specimens from dogs with GI signs were examined. The study groups were dogs with eosinophilic enteritis (EE), ...
Eosinophils are multifunctional leukocytes playing important roles in allergic inflammation and helminth infections. Although most research concerning eosinophils has focused on understanding their function in the blood and lung, it should be noted that eosinophils are much more abundant in the lamina propria (LP) of gastrointestinal (GI) tract than in other tissues. In this study, CD11bhighCD11cint cells, representing an almost pure population of eosinophils, were successfully isolated from the small intestinal LP wild type mice and this subset was not found in the LP of the genetically engineered eosinophil-deficient dblGATA mice. The CD11bhighCD11cint cells had prominent eosinophilic granules in the cytoplasm. Electron microscopic examination demonstrated that a significant fraction of the cytoplasmic granules were bi-compartmental, with an electron-dense or -lucent crystalline core. LP eosinophils express substantially lower levels of L-selectin, PSGL-1, integrin α4β7, and IL-5Rα and ...
IL-33 has emerged as an important cytokine in allergic diseases, largely because of its potential to activate cells that are hallmarks of allergy, including eosinophils, mast cells, and basophils (31). Outside of allergy, IL-33 has also been proposed to be involved in bacterial and viral infections, tumorigenesis, autoimmunity, fibrosis (32), and more recently, hematopoiesis (23, 33). In this article, we define a previously unappreciated mechanism for IL-33 in regulating eosinophil commitment.. Our data demonstrate that IL-33 directs the eosinophil compartment by expanding the EoPre frequency and upregulating IL-5Rα to license the responsiveness of these precursors to IL-5 within the bone marrow. Importantly, the defects in basal eosinophil populations we identified in the IL-33 KO and ST2 KO mice strongly implicate a homeostatic contribution of this cytokine that functions outside of a disease pathogenesis setting. Indeed, the previously defined function of IL-33 as an alarmin released upon ...
Eosinophil cell. Coloured Transmission Electron Micrograph (TEM) of a human eosinophil cell, containing granules with crystal inclusions in its cytoplasm. Granules (red) are seen in the cell cytoplasm (orange); the large cell nucleus is yellow and purple. Eosinophils are white blood cells, known also as granulocytes for the granular cytoplasm they possess. These oval-shaped granules contain enzymes responsible for bacterial destruction. The function of the crystals is unknown. Eosinophil cells, produced in the bone marrow, play an important role in the immune response against allergic and parasitic diseases. Magnification: x6,800 at 6x7cm. - Stock Image P248/0165
Looking for online definition of eosinophil or what eosinophil stands for? eosinophil is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
Eosinophils migrating to different tissues in the body are part of its function[45]. Eosinophils that are part of the circulatory system remain inactive until they reach the tissue[46]. When eosinophils migrate to endothelial cells, interleukin (IL)-4 or IL-Beta encouragse further migration[46]. The rate of this process further increases if a chemoattractant is used[46]. In an experiment where a culture is used, the endothelial cells that were treated to prevent this chemotactic event lead to a decrease in the expression of CD68[46]. CD69 is an early marker and CD35 is a receptor[47]. Both of these are controlled by endothelial cells and thus their expression increased when the eosinophils migrated to the endothelial cells[47]. Granules express receptors for cytokines and G protein coupled receptors (CCR3) for chemokines. These are located on their surface membranes and respond to external cytokines and chemokines by activating a signal-transduction pathway within. IFN-γ (cytokine) and eotaxin ...
There has been increasing research on the role of eosinophils and connective tissue disorders. The eosinophils main role is fighting off parasitic infections, however they also play a huge part in allergic responses and inflammation. They release many cytotoxic and neurotoxic chemicals that ...
UCB Eosinophil Chip-IHC from 3H Biomedical AB,Umbilical cord blood eosinophils, For immunohistochemistry (IHC),biological,biology supply,biology supplies,biology product
TY - CHAP. T1 - Eosinophils and Anti-Pathogen Host Defense. AU - Gleich, Gerald J.. AU - Leiferman, Kristin. AU - Simon, Hans Uwe. AU - Yousefi, Shida. AU - Rosenberg, Helene F.. AU - Dyer, Kimberly D.. AU - Domachowske, Joseph B.. AU - Kita, Hirohito. PY - 2013/8/29. Y1 - 2013/8/29. UR - UR - U2 - 10.1016/B978-0-12-394385-9.00009-2. DO - 10.1016/B978-0-12-394385-9.00009-2. M3 - Chapter. AN - SCOPUS:84882913043. SN - 9780123943859. SP - 277. EP - 299. BT - Eosinophils in Health and Disease. PB - Elsevier Inc.. ER - ...
chemotactic factor for and activator of eosinophils. studies needed to determine if inhibiting its production or action ... or pathogens such as chemotactic factors, cytokines, growth factors, and even certain eicosanoids. The activated cells then ... chemotactic factor for and activator of leukocytes; inflammation. studies to date shown no clear benefits of LTB4 receptor ... cPLA2 may also release the lysophospholipid that becomes platelet-activating factor.[28] ...
... may refer to: Eosinophil chemotactic factor of anaphylaxis, released from mast cell granules. Economic Cooperation ...
Monocytes: inhibit their migration response to chemotactic factors and release of pro-inflammatory mediators. Lymphocytes: ... Mouse eosinophils metabolize DHA to a marisen-like product, 14S,20R-dihydroxy-4Z,7Z,10Z,12E,16Z,18Z-docosahexaenoic acid. This ... complement components C5a and C3a which are chemotactic factors formed during the activation of the host's blood complement ... foreign organism-derived N-formylated oligopeptide chemotactic factors (e.g. N-formylmethionine-leucyl-phenylalanine); b) ...
Release into the Circulation of Histamine and Eosinophil Chemotactic Factor of Anaphylaxis during Cold Challenge". New England ...
Part of this cell response is brought on by inflammatory mediators such as chemotactic factors. Other processes involved with ... "Higher" eosinophil count was chosen, rather than specifying a particular value as it is not clear what the precise threshold ... Other genetic factors are being investigated, of which many are likely. A number of other factors are less closely linked to ... The primary risk factor for COPD globally is tobacco smoking. Of those who smoke, about 20% will get COPD, and of those who are ...
Thus, chemotactic factor CCL7 recruits leukocytes to infected tissues to mediate the immune response. Furthermore, CCL7 has an ... CC7 mainly acts as a chemoattractant for several leukocytes, including monocytes, eosinophils, basophils, dendritic cells (DCs ... Van Coillie E, Van Damme J, Opdenakker G (March 1999). "The MCP/eotaxin subfamily of CC chemokines". Cytokine & Growth Factor ... Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (March 1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular ...
Sehmi R, Cromwell O, Taylor GW, Kay AB (1991). "Identification of guinea pig eosinophil chemotactic factor of anaphylaxis as ...
5-Oxo-ETE is a particularly potent chemotactic factor for and activator of eosinophils and may thereby contribute to eosinophil ... potent chemotactic factor, LTB4, and possibly also weaker chemotactic factor, 5S-HETE, which serve to attract and otherwise ... On the other hand, 5-oxo-ETrE is almost as potent as 5-oxo-ETE as an eosinophil chemotactic factor and may thereby contribute ... For example, chemotactic factors stimulate human neutrophils to raise cytosolic Ca2+ which triggers cPLA2s, particularly the α ...
... such as eosinophil chemotactic factor reactive oxygen species Histamine dilates post-capillary venules, activates the ... D2 leukotriene C4 platelet-activating factor cytokines TNF-α basic fibroblast growth factor interleukin-4 stem cell factor ... March 1984). "Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E ... ISBN 978-0-321-20413-4. Prussin C, Metcalfe DD (February 2003). "4. IgE, mast cells, basophils, and eosinophils". The Journal ...
Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic ... CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. This chemokine is also strongly chemotactic ... for resting T lymphocytes and slightly chemotactic for neutrophils. Elevated levels of eotaxin-2 has been seen in patients with ... and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils ...
... including eosinophil chemotactic factor of anaphylaxis, leukotriene B4 and serotonin mediated release of eosinophil granules ... eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived neurotoxin). These agents serve to orchestrate ... Eosinophils usually account for less than 7% of the circulating leukocytes. A marked increase in non-blood tissue eosinophil ... Elevations in blood eosinophil counts can be transient, sustained, recurrent, or cyclical. Eosinophil counts in human blood ...
Initially thought to be a second and low affinity receptor for the neutrophil tripeptide chemotactic factor, N-formyl-met-leu- ... eosinophil, mast cell, and various types of lymphocytes and accordingly are regarded primarily as contributing to the many ... 12-HHT stimulates chemotactic responses in mouse bone marrow mast cells, which naturally express BLT2 receptors, as well as in ... These findings suggest that the 12-HHT/BLT2 receptor pathway may support the pro-inflammatory (i.e. chemotactic) actions of the ...
... including eosinophil chemotactic factor of anaphylaxis, leukotriene B4 and serotonin mediated release of eosinophil granules ... Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5.0×108/l (500/μL).[1] Eosinophils ... Accumulation of eosinophils in tissues can be significantly damaging. Eosinophils, like other granulocytes, contain granules ( ... An absolute eosinophil count is not generally needed if the CBC shows marked eosinophilia.[3] The location of the causal factor ...
... exhibits a chemotactic activity for monocytes and basophils. However, it does not attract neutrophils or eosinophils. ... "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)". Biochemical and Biophysical ... Platelet derived growth factor is a major inducer of CCL2 gene. CCR2 and CCR4 are two cell surface receptors that bind CCL2. ... In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and it is under control of nuclear factor κB (NFκB). In ...
DP2, is related to members of the chemotactic factor class of GPCRs, sharing an amino acid sequence identity of 29% with the ... eosinophils, basophils, and Th2 cells. DP2 activation also stimulates eosinophils and basophils to release the many pro- ... Ligand-induced activation of DP2 has similar activities in vivo it stimulates the accumulation on and activation of eosinophils ... eosinophils, a subpopulation of cytotoxic T cells (i.e. CD8+ T cells), thalamus, ovary, and spleen, and, in the central nervous ...
Part of this cell response is brought on by inflammatory mediators such as chemotactic factors. Other processes involved with ... "Higher" eosinophil count was chosen, rather than specifying a particular value as it is not clear what the precise threshold ... The primary risk factor for COPD globally is tobacco smoking.[9] Of those who smoke, about 20% will get COPD,[44] and of those ... The most common cause of COPD is tobacco smoking, with a smaller number of cases due to factors such as air pollution and ...
The eotaxins are a CC chemokine subfamily of eosinophil chemotactic proteins. In humans, there are three family members: CCL11 ... Cytokine Growth Factor Rev. 10 (1): 61-86. doi:10.1016/s1359-6101(99)00005-2. PMID 10379912. v t e. ...
... to form a cluster which also includes the genes for another G protein-coupled chemotactic factor receptor, the C5a receptor ( ... FPL3 is expressed by circulating monocytes, eosinophils, and basophils but not neutrophils; tissue macrophages and dendritic ... Growth Factor Reviews. 17 (6): 501-19. doi:10.1016/j.cytogfr.2006.09.009. PMID 17084101. He HQ, Liao D, Wang ZG, Wang ZL, Zhou ... "Identification and characterization of an endogenous chemotactic ligand specific for FPRL2". The Journal of Experimental ...
The interactions of 5-oxo-ETE with these mediators of allergy (e.g. platelet-activating factor, interleukin 5) in eosinophils ... a key mediator in eosinophil activation) also increases their in vitro chemotactic response to 5-oxo-ETE. 5-Oxo-ETE also acts ... tumor necrosis factor α, or various nucleotides including ATP. Pretreament of eosinophils with interleukin 5 ( ... and production of mediators such as various arachidonic acid metabolites and platelet-activating factor in human eosinophils, ...
... this cluster also includes the genes for two other chemotactic factor receptors, the G protein-coupled C5a receptor (also ... Svensson L, Dahlgren C, Wennerås C (Oct 2002). "The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the ... Shen W, Proost P, Li B, Gong W, Le Y, Sargeant R, Murphy PM, Van Damme J, Wang JM (May 2000). "Activation of the chemotactic ... It is widely expressed by circulating blood neutrophils, eosinophils, basophils, and monocytes; lymphocyte T cells and B cells ...
... is a G protein coupled receptor initially identified as a receptor for the leukocyte chemotactic factor, N-Formylmethionine- ... Powell WS, Chung D, Gravel S (1995). "5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil ... LXA4 and 15-epi-LTA4 also act by mobilizing transcription factors that regulate expression of various inflammation-regulating ... eosinophils, monocytes, Innate lymphoid cells, and/or macrophages, as well as suppress proliferation and production of IgM and ...
... is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and ... cellular response to fibroblast growth factor stimulus. • neutrophil chemotaxis. • response to tumor necrosis factor. • ... 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): ... eosinophil chemotaxis. • dendritic cell chemotaxis. • MAPK cascade. • macrophage chemotaxis. • positive regulation of T cell ...
C3a is a neutrophil chemotactic factor which operates through a G protein coupled chemotactic factor receptor, the C3a receptor ... FPR1 is widely expressed by circulating blood neutrophils, eosinophils, basophils, monocytes, and platelets; tissue-bound ... suggested that the N-formyl oligopeptides are important chemotatic factors and their receptors are important chemotactic factor ... is a neutrophil chemotactic factor that operates through receptors whose genes cluster with those for the three formyl peptide ...
One factor that was initially found to influence haptotaxis is serum spreading factor, which is present in blood serum and ... This actin regulatory protein binds to fibronectin receptors and aids in the haptotactic and chemotactic processes of tumor ... eosinophils and some T cells are influenced by RANTES chemokines. In the autoimmune disorder rheumatoid arthritis and in ... In nerve cells, axonal growth is mediated by nerve growth factor in a haptotactic manner, where the axon of nerve cells grows ...
... is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and ... It is also an HIV-suppressive factor released from CD8+ T cells This chemokine has been localized to chromosome 17 in humans. ... 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): ... RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13). RANTES, along with the related chemokines ...
The "classic" triad of symptoms reported in early documented cases consisted of rash, joint pain, and increased eosinophils in ... There are a variety of known factors that can provoke the inflammatory process within the renal interstitium, including ... One study showed that monocyte chemotactic protein-1 (chemokine CCL-2) and neutrophil gelatinase associated lipocalin (NGAL) ... About 23% of patients have a high level of eosinophils in the blood. Urinary findings include: Eosinophiluria: Original studies ...
Goetzl EJ, Gorman RR (Feb 1978). "Chemotactic and chemokinetic stimulation of human eosinophil and neutrophil polymorphonuclear ... Both receptor types bind and are activated by a series of formylated oligopeptide chemotactic factors but FLP2 receptor appears ... Kim H, Choi JA, Kim JH (Aug 2014). "Ras promotes transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition ... The high affinity BLT2 receptor agonist, 12-HHT, stimulates in vitro chemotactic responses in human neutrophils, suggesting ...
It has chemotactic properties for monocytes and eosinophils and is expressed by macrophages, basophils and some tissue cells. ... Menten P, Wuyts A, Van Damme J (December 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): ... Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are ... MIP-1 are best known for their chemotactic and proinflammatory effects but can also promote homeostasis. Biophysical analyses ...
Main articles: Basophil granulocyte and Eosinophil granulocyte. Basophils and eosinophils are cells related to the neutrophil ( ... Chemical factors produced during inflammation attract phagocytes, especially neutrophils.[5] Neutrophils then trigger other ... and chemotactic cytokines into the environment. Histamine dilates blood vessels, causing the signs of inflammation, and ... The innate leukocytes include: Natural killer cells, mast cells, eosinophils, basophils; and the phagocytic cells including ...
Basophils and eosinophils[edit]. Main articles: Basophil granulocyte and Eosinophil granulocyte. Basophils and eosinophils are ... where they induce IFN production with the presence of a particular transcription factor and activate transcription factor 2. ... or chemotactic cytokines into the environment. Histamine dilates blood vessels, causing the characteristic signs of ... Chemical factors produced during inflammation (histamine, bradykinin, serotonin, leukotrienes, and prostaglandins) sensitize ...
3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): ... Enhanced expression of elongation factor EF-1 alpha". J. Biol. Chem. 263 (8): 3546-9. PMID 3346208.. CS1 одржавање: Експлицитна ... 1990). „Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family". Nucleic Acids Res. 18 ( ... 1989). „Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine- ...
Eosinophils[edit]. Main article: Eosinophil. Eosinophils also have kidney-shaped lobed nuclei (two to four lobes). The number ... Granule contents of basophils are abundant with histamine, heparin, chondroitin sulfate, peroxidase, platelet-activating factor ... There is usually a granulocyte chemotactic defect in individuals suffering from insulin-dependent diabetes mellitus. ... of granules in an eosinophil can vary because they have a tendency to degranulate while in the blood stream.[16] Eosinophils ...
5-Oxo-ETE is a particularly potent chemotactic factor for and activator of eosinophils and may thereby contribute to eosinophil ... potent chemotactic factor, LTB4, and possibly also weaker chemotactic factor, 5S-HETE, which serve to attract and otherwise ... On the other hand, 5-oxo-ETrE is almost as potent as 5-oxo-ETE as an eosinophil chemotactic factor and may thereby contribute ... For example, chemotactic factors stimulate human neutrophils to raise cytosolic Ca2+ which triggers cPLA2s, particularly the α ...
Eosinophils: the migration of eosinophils into various tissues involved several chemokines of CC family: CCL11, CCL24, CCL26, ... Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cyto ... Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an ... Chemokines CCL11 (eotaxin) and CCL5 (RANTES) acts through a specific receptor CCR3 on the surface of eosinophils, and eotaxin ...
Platelets release a multitude of growth factors including platelet-derived growth factor (PDGF), a potent chemotactic agent, ... Granulocytes include basophils, eosinophils, neutrophils, and mast cells. Agranulocytes include lymphocytes and monocytes. ... insulin-like growth factor 1, platelet-derived epidermal growth factor, and vascular endothelial growth factor. Local ... Other healing-associated growth factors produced by platelets include basic fibroblast growth factor, ...
The factors that dictate whether an infection triggers a Th1 or Th2 type response are not fully understood, but the response ... The Th2 response is characterized by the release of Interleukin 5, which induces eosinophils in the clearance of parasites.[7] ... via chemotactic signals, to the T cell-enriched lymph nodes. During migration, dendritic cells undergo a process of maturation ... Over the last century, two important factors have been developed to combat their spread: sanitation and immunization.[5] ...
... its production appears necessary for epidermal growth factor and tumor growth factor α to stimulate cultured BT-20 human breast ... Henricks, P. A; Engels, F; Van Der Vliet, H; Nijkamp, F. P (1991). "9- and 13-hydroxy-linoleic acid possess chemotactic ... and human eosinophils, which are implicated in contributing to human asthma, metabolize linoleic acid to 13-HODE (and 9-HODE) ... Further studies suggest that 13(S)-HODE contributes to plaque formation by activating the transcription factor, PPARγ (13(R)- ...
DP2, is related to members of the chemotactic factor class of GPCRs, sharing an amino acid sequence identity of 29% with the ... eosinophils, basophils, and Th2 cells. DP2 activation also stimulates eosinophils and basophils to release the many pro- ... in human eosinophils and basophils". The Journal of Biological Chemistry. 279 (9): 7663-70. doi:10.1074/jbc.M310270200. PMID ... in eosinophil trafficking". Journal of Immunology. 179 (7): 4792-9. doi:10.4049/jimmunol.179.7.4792. PMID 17878378.. ...
CXCL8 (IL-8) forms a chemotactic gradient that directs leukocytes towards site of tissue injury/infection (CCL2 has a similar ... This is assisted through juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In ... Once in the interstitial fluid, leukocytes migrate along a chemotactic gradient towards the site of injury or infection. ... Intracellular integrin domains associate with the leukocyte cytoskeleton, via mediation with cytosolic factors such as talin, α ...
... and in cooperation with Tumor necrosis factor alpha or Platelet-activating factor, to release their granule-bound enzymes; c) ... Stenson, W. F.; Parker, C. W. (1979). "12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, a chemotactic fatty acid, is incorporated ... eosinophils, monocytes, spleen, liver, and ovary. However, 12-Hydroxyheptadecatrienoic acid (i.e. 12-(S)-hydroxy-5Z,8E,10E- ... Yoo, H; Kim, S. J.; Kim, Y; Lee, H; Kim, T. Y. (2007). "Insulin-like growth factor-II regulates the 12-lipoxygenase gene ...
... factor VIII, fibrinogen, fibronectin, platelet-derived growth factor, and chemotactic agents. Delta granules, or dense bodies, ... fibroblast growth factor, insulin-like growth factor 1, platelet-derived epidermal growth factor, and vascular endothelial ... Platelets release platelet-derived growth factor (PDGF), a potent chemotactic agent; and TGF beta, which stimulates the ... Tissue factor also binds to factor VII in the blood, which initiates the intrinsic coagulation cascade to increase thrombin ...
These cells include T cells, dendritic cells, macrophages, mast cells, basophils, eosinophils, epithelial cells and Paneth ... Growth Factor Reviews. 14 (2): 155-74. doi:10.1016/S1359-6101(03)00002-9. PMID 12651226. Rickel EA, Siegel LA, Yoon BR, Rottman ... which is the major chemotactic substance of neutrophils. Another important function of interleukin 25 is to support the Th2 ... "Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma". Clinical and Translational Allergy. 8: 5. doi: ...
Eosinophils also have kidney-shaped lobed nuclei (two to four lobes). The number of granules in an eosinophil can vary because ... There is usually a granulocyte chemotactic defect in individuals suffering from type 1 diabetes mellitus. Research suggests ... platelet-activating factor, and other substances. When an infection occurs, mature basophils will be released from the bone ... Eosinophils play a crucial part in the killing of parasites (e.g., enteric nematodes) because their granules contain a unique, ...
Neutrophils and eosinophils will contain hyposegmented nuclei (a pseudo-Pelger-Huet anomaly). A majority of patients with SGD ... Khanna-Gupta A, Sun H, Zibello T, Lee HM, Dahl R, Boxer LA, Berliner N (2007). "Growth factor independence-1 (Gfi-1) plays a ... Neutrophils will also display abnormal chemotaxis, such as a decreased response to fMLP, due to a lack of chemotactic receptors ... "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/ ...
Farber JM (July 1990). "A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 ... "CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma". ... CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3. CXCL9, -10, -11 have ... and acts as functional receptor for platelet factor 4". The Journal of Experimental Medicine. 197 (11): 1537-49. doi:10.1084/ ...
... its production appears necessary for epidermal growth factor and tumor growth factor α to stimulate cultured BT-20 human breast ... While much further work is needed, these pre-clinical studies allow that 13(S)-HODE, made at least in part by eosinophils and ... Henricks, P. A; Engels, F; Van Der Vliet, H; Nijkamp, F. P (1991). "9- and 13-hydroxy-linoleic acid possess chemotactic ... Further studies suggest that 13(S)-HODE contributes to plaque formation by activating the transcription factor, PPARγ (13(R)- ...
Eosinophil chemotactic factor of anaphylaxis definition at, a free online dictionary with pronunciation, ... eosinophil chemotactic factor of anaphylaxis in Medicine Expand. eosinophil chemotactic factor of anaphylaxis n. Abbr. ECF-A A ...
eosinophil chemotactic factor help. Discussion of all aspects of cellular structure, physiology and communication. ... about the eosinophil chemotactic factor. I was wondering if someone could point me in the right direction for a few answers. My ... 1. Name of signal (I assume this is obvious: Eosinophil chemotactic peptide). 2. Type of signal (peptide?). 3. Mode of signal ... 6. Gene function it controls (responsible for accumulation of eosinophils at sites of inflammation?). I also have to find the ...
eosinophil chemotactic factor help. Discussion of all aspects of cellular structure, physiology and communication. ... eosinophil chemotactic factor help. by relamberth » Tue Dec 01, 2009 11:23 pm ... about the eosinophil chemotactic factor. I was wondering if someone could point me in the right direction for a few answers. My ... 1. Name of signal (I assume this is obvious: Eosinophil chemotactic peptide). 2. Type of signal (peptide?). 3. Mode of signal ...
What is Eosinophil Chemotactic Factor? Meaning of Eosinophil Chemotactic Factor as a finance term. What does Eosinophil ... Definition of Eosinophil Chemotactic Factor in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Related to Eosinophil Chemotactic Factor: neutrophil chemotactic factor, eosinophil chemotactic factor of anaphylaxis ... Eosinophil Chemotactic Factor financial definition of Eosinophil Chemotactic Factor https://financial-dictionary. ...
... may be responsible for accumulation of eosinophils at sites of... Explanation of eosinophil chemotactic factor ... Find out information about eosinophil chemotactic factor. A peptide released from mast cell granules that stimulates chemotaxis ... Related to eosinophil chemotactic factor: neutrophil chemotactic factor, eosinophil chemotactic factor of anaphylaxis ... Eosinophil chemotactic factor , Article about eosinophil chemotactic factor by The Free Dictionary https://encyclopedia2. ...
eosinophil chemotactic factor answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for ... factor. Eosinophil Chemotactic Factor [Internet]. In: Venes D, editors. Tabers Medical Dictionary. F.A. Davis Company; 2017. [ ... factor. Accessed October 29, 2020.. Eosinophil chemotactic factor. (2017). In Venes, D. (Ed.), Tabers Medical Dictionary (23rd ... eosinophil chemotactic factor is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please sign in or ...
Rat ECF(Eosinophil Chemotactic Factor) ELISA Kit. Rat ECF(Eosinophil Chemotactic Factor) ELISA Kit ... Should the Human Eosinophil Chemotactic Factor (ECF) ELISA Kit is proven to show malperformance, you will receive a refund or a ... Should the Human Eosinophil Chemotactic Factor (ECF) ELISA Kit is proven to show malperformance, you will receive a refund or a ... Should the Mouse Eosinophil Chemotactic Factor (ECF) ELISA Kit is proven to show malperformance, you will receive a refund or a ...
What is mast cell growth factor? Meaning of mast cell growth factor medical term. What does mast cell growth factor mean? ... Looking for online definition of mast cell growth factor in the Medical Dictionary? mast cell growth factor explanation free. ... eosinophil chemotactic factor. A mediator released in response to inflammation when mast cells are injured. ... factor X, Stuart-Prower factor; factor XI, plasma thromboplastin antecedent; factor XII, Hageman factor; factor XIII, fibrin- ...
ELISA Kit for Eosinophil Chemotactic Factor (ECF) - Simian (Rhesus Monkey) by USCNK ... This assay has high sensitivity and excellent specificity for detection of Eosinophil Chemotactic Factor (ECF). No significant ... Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Eosinophil Chemotactic Factor (ECF ... Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Eosinophil Chemotactic Factor (ECF ...
Eosinophil Chemotactic Protein 1, Chemokine C-C-Motif Ligand 11, Small Inducible Cytokine Subfamily A(Cys-Cys)Member 11, ... ELISA Kit for Eosinophil Chemotactic Factor (ECF), Homo sapiens (Human), Sandwich ELISA, CCL11, SCYA11, Eotaxin 1, ... ELISA Kit for Eosinophil Chemotactic Factor (ECF) CCL11; SCYA11; Eotaxin 1; Eosinophil Chemotactic Protein 1; Chemokine C-C- ... The concentration of Eosinophil Chemotactic Factor (ECF) in the samples is then determined by comparing the O.D. of the samples ...
Thus, the macrophage has to be added to the list of cells able to regulate eosinophil accumulation at tissue sites. ... A low molecular weight eosinophil chemotactic factor (ECF) which has previously been found within mast cells and ... Chemotactic Factors, biosynthesis, Chemotactic Factors, Eosinophil, Chemotaxis, Leukocyte, drug effects, Eosinophils, ... An eosinophil leukocyte chemotactic factor of anaphylaxis. J. Exp.. Vol. 133. pp. 602 (1970) Kay A.B. et al. ...
Chemotactic Factors. Cytotaxins liberated from normal or invading cells that specifically attract macrophages. They may be ...
Porcine ECFR(Eosinophil Chemotactic Factor Receptor) ELISA Kit. Código: E-EL-P0935 Marca: ELABSCIENCE ...
RANTES is a chemotactic and activating factor for human eosinophils. In: Journal of Immunology. 1993 ; Vol. 150, No. 8 PART 1. ... RANTES is a chemotactic and activating factor for human eosinophils. Journal of Immunology. 1993;150(8 PART 1):3442-3447. ... RANTES is a chemotactic and activating factor for human eosinophils. Rafeul Alam, Susan Stafford, Patricia Forsythe, Robert ... RANTES is a chemotactic and activating factor for human eosinophils. / Alam, Rafeul; Stafford, Susan; Forsythe, Patricia; ...
factor answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, ... eosinophil chemotactic factor. A mediator released in response to inflammation when mast cells are injured. ... factor X, Stuart-Prower factor; factor XI, plasma thromboplastin antecedent; factor XII, Hageman factor; factor XIII, fibrin- ... factor I, fibrinogen; factor II, prothrombin; factor III, thromboplastin; factor IV, calcium (ions); factor V, proaccelerin; ...
... we found a dramatic up-regulation of a recently described eosinophil chemotactic factor, eosinophil chemotactic factor-L/Ym1, ... Production of eosinophil chemotactic factor by CD8+ T cells in Toxocara canis-infected mice. Parasitol. Res. 84: 136. ... We also find that Bm-MIF-1 increases the transcription rate of a gene encoding a novel eosinophil chemotactic factor (ECF-L), ... eosinophil chemotactic factor; PEC, peritoneal exudate cells; EST, expressed sequence tag. ...
chemotactic factor for and activator of eosinophils. studies needed to determine if inhibiting its production or action ... or pathogens such as chemotactic factors, cytokines, growth factors, and even certain eicosanoids. The activated cells then ... chemotactic factor for and activator of leukocytes; inflammation. studies to date shown no clear benefits of LTB4 receptor ... cPLA2 may also release the lysophospholipid that becomes platelet-activating factor.[28] ...
Eosinophil chemotactic factor (ECF). Neutrophil chemotactic factor (NCF) 114 Secondary mediators of mast cells during ... 1-permanent=integrins (adhesion molecules), growth factors. 2-Transient=Ilk, GF, tumor necrosis factors, interferons, hormones ... PMN, Eosinophils, monocyte, lymphocyte, basophil. Circulate in peripheral blood and enter CT to perform special fxn. Bone ... Eosinophils limit magnitude of inflamm by mast cells by inactivating inflamm mediators like histamine and leukotrienes ...
... whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the ... 0/Chemotactic Factors, Eosinophil; 0/Cytokines; 0/Progesterone Congeners; 0/Tumor Necrosis Factor-alpha; 50-28-2/Estradiol; 520 ... Chemotactic Factors, Eosinophil / chemistry, metabolism*. Cytokines / chemistry, metabolism*, pharmacology. Endometriosis / ... Given evidence of autoimmune activity in the endometriosis syndrome, we hypothesized that eosinophil chemoattractants might be ...
... eosinophil chemotactic factor. A type 2 hypersensitivity reaction involves what antibodies binding to what?. IgG and IgM bind ... Cell derived chemotactic agent; chemokine for neutrophils only. What does TNF do an inflammation mediator?. Causes cell death ... Activated by the coagulation system -,Hageman Factor. The complement system is a family of 20 proteins, what are the 4 most ... Platelet activating factor is derived from and is what?. membrane phospholipids; very potent and versatile mediator. ...
Chemotactic factor for monocytes, lymphocytes, eosinophils, and basophils. 1.91. PROS1. Anticoagulant plasma protein, ... Tumor necrosis factor (TNF) receptor, activates nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB), ... epidermal growth factor (EGF) (20 ng/mL, Invitrogen, Waltham, MA, USA), basic fibroblast growth factor (bFGF) (20 ng/mL, ... Complement Factor B, cleaved into Ba and Bb which further activate the complement cascade and monocyte response, Ba inhibits ...
IL-5 as an eosinophil chemotactic factor. J. Exp. Med. 167:1737-1742, pmid:2835420.. ... Eosinophil Assays.. Eosinophils were obtained from either the spleen or blood of transgenic mice expressing the IL-5 gene in ... Eosinophil Production Is Impaired in CCR8−/− Mice.. As CCR8 was not normally expressed by peripheral eosinophils, then impaired ... Circulating eosinophils lack CCR8 mRNA and are unresponsive to CCR8 ligands. (A) Eosinophils isolated from the blood of IL-5 ...
Platelet activating factor Eosinophil chemotactic facotr 16 Where does histamine come from? ...
eosinophil chemotactic factor of anaphylaxis; a primary mediator of Type I anaphylactic hypersensitivity. It is an acidic ... peptide (molecular weight 500) released by mast cells, which attracts eosinophils to areas where it is present. ...
These include histamine, Eosinophil Chemotactic Factor (ECF-A) and leukotrienes. These chemical mediators are pharmacologically ...
Categories: Chemotactic Factors, Eosinophil Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Kay, A. B., and Austen, K. F., 1971, The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung, J ... Kay, A. B., Stechschulte, D. J., and Austen, K. F., 1971, An eosinophil leukocyte chemotactic factor of anaphylaxis, J. Exp. ... Wasserman, S. I., Soter, N. A., Poser, J., and Austen, K. F., 1980, Eosinophil chemotactic factors in human disease: Evidence ... Czarnetski, B. M., König, W., and Lichtenstein, L. M., 1976b, Antigen-induced eosinophil chemotactic factor (ECF) release by ...
Specifically, C3a and C5a act as chemotactic factors aiding eosinophil recruitment (40). Despite all three pathways being ... While eosinophils release IL-4 and aid in type 2 T cell polarization, eosinophil deficient mice still mount a normal T helper ... deletion of eosinophils in animal models has been shown to increase parasite survival (38, 39). Reduction of eosinophils ... Basic Leucine Zipper ATF-Like Transcription Factor (BATF), an AP-1 superfamily transcription factor, is critical for activation ...
Estrogen regulation of an eosinophil chemotactic factor in the immature rat uterus. Endocrinology (1989) 125:3022-8. doi: ... Major basic protein, eosinophil peroxidase, eosinophil cationic protein, and eosinophil-derived neurotoxin are among the ... Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J Clin Invest ( ... Eosinophils. Eosinophils are a hallmark cell type of allergic inflammation. These cells are recruited from the blood by IL-5, ...
Eosinophil Chemotactic Factor in Schistosome Eggs: A Comparative Study of Eosinophil Chemotactic Factors in the Eggs of ... Gel filtration on Sephadex G-150 showed that S. japonicum SEA was composed of two groups of eosinophil chemotactic factors ( ... Significant chemotactic activity for eosinophils was detected in soluble egg antigen (SEA) preparations of both Schistosoma ... and granulomata composed of eosinophils, macrophages and lymphocytes. In that group, the hepatocellular damage was less ...
  • Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. (
  • and attracting to nascent inflammatory sites and activating circulating neutrophils, monocytes, eosinophils, gamma delta T cells, and Natural killer T cells. (
  • There is less evidence for the involvement of neutrophils in asthma than for eosinophils, but neutrophils may have greater importance in the pathogenesis of severe asthma. (
  • This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. (
  • Shows specific chemotactic CC activity towards neutrophils and activates them to induce release CC of eosinophil chemotactic factors. (
  • Gross T et al (2005) Nodular and diffuse diseases of the dermis with prominent eosinophils, neutrophils or plasma cells . (
  • It was active in vitro at an effective concentration between 10 and 100 ng/ml in both chemotaxis and calcium flux assays toward eosinophils, but not macrophages or neutrophils. (
  • Chemotactic factors attract and activate neutrophils, eosinophils, mast cells, and lymphocytes and further activate macrophages to release more oxidants. (
  • Oxidants in the lung can be from endogenous sources since air pollutants activate neutrophils, alveolar macrophages, eosinophils, and epithelial cells. (
  • The family includes immune cells known as neutrophils, eosinophils, and basophils. (
  • Neutrophils, basophils, and eosinophils are all PMNs that can be found circulating in the bloodstream. (
  • When there is a tissue injury, substances called chemotactic factors are released which attract neutrophils. (
  • Granulocytes have a segmented nucleus and are classified according to their staining characteristics as neutrophils , eosinophils , or basophils . (
  • Monocyte Chemotactic Protein-1 (MCP-1) is a chemotactic factor that belongs to CC chemokine family and can attract basophils and monocytes but not eosinophils or neutrophils. (
  • To evaluate the potential role of alveolar macrophages in modulating the migration of neutrophils to the lung, normal human alveolar macrophages obtained from volunteers by bronchopulmonary lavage, were exposed for various periods of time in vitro to heat-killed microorganisms, and noninfectious particulates, immune complexes, and the macrophage supernates were evaluated for chemotactic activity. (
  • After incubation with each of these stimuli, alveolar macrophages released low molecular weight (400-600) chemotactic factor(s) (alveolar macrophage-derived chemotactic factor[s] [AMCF]) with relatively more activity for neutrophils than monocytes or eosinophils. (
  • Checker-board analysis of the AMCF revealed that the factor was primarily chemotactic and not chemokinetic for neutrophils. (
  • These studies suggest that a wide variety of potentially pathogenic stimuli induce normal alveolar macrophages to generate a low molecular weight chemotactic factor(s) that preferentially attracts neutrophils. (
  • [6] [7] Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (
  • The cellular components comprise a variety of cells including eosinophils, mast cells, lymphocytes, neutrophils and plasma cells. (
  • Eosinophils are the dominant cell type except in cystic fibrosis which contain more neutrophils and relatively fewer eosinophils. (
  • IL-8, which is a known chemotactic factor for neutrophils is also increased in nasal polyp tissue. (
  • Pleural involvement in certain diseases is associated with the infiltration of a number of different types of immune cells, such as neutrophils, eosinophils or lymphocytes, in various proportions depending on both the course and the aetiology of the underlying disease. (
  • RANTES is a member of the 8-kDa cytokine family that has been shown to possess chemotactic activity for monocytes and CD4 T cells. (
  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. (
  • 1994. Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma. (
  • RANTES (regulated upon activation, normally T-cell expressed and presumably secreted) is a CC chemokine which recruits and activates monocytes, lymphocytes, and eosinophils, all cell types present in the lung inflammatory infiltrate induced by RSV infection. (
  • In adult life, macrophages are derived from bone marrow stem cells in response to monocyte colony stimulating factor to form monocytes (the precursor of macrophages), circulating in the blood. (
  • Ccl8 and Ccl12 are chemotactic factors that attract monocytes, lymphocytes, basophils and eosinophils to sites of injury or infection through association with CCR8 (chemokine (C-C motif) receptor 8) and CCR2, respectively. (
  • Peripheral monocytes obtained from hypercholesterolemic patients demonstrate increased adhesion to the endothelium 1-3 and an increased chemotactic response to chemokines. (
  • 6 Additional reports 7,8 suggest that plasma lipoproteins differentially control monocyte function, and that monocytes from hypercholesterolemic subjects are hyper-responsive to chemotactic stimuli, suggesting a close relationship between plasma lipids and monocyte function. (
  • Because B. malayi is known to secrete homologs ( Bm macrophage migration inhibitory factor (MIF)-1 and -2) of the human cytokine MIF, we chose to investigate the role this cytokine mimic may play in the development of the novel macrophage phenotype observed during infection. (
  • These data suggest that macrophages may provide a crucial link between helminth parasites, their active cytokine mimics, and the recruitment of eosinophils in infection. (
  • Remarkably, we show that a cytokine homolog secreted by the nematode parasite ( Bm macrophage migration inhibitory factor (MIF)-1) is involved in activating macrophages and is sufficient for the recruitment of eosinophils. (
  • In these mice, the response to SEA, OVA, and CRA showed impaired Th2 cytokine production that was associated with aberrant type 2 inflammation displaying a 50 to 80% reduction in eosinophils. (
  • These studies revealed impaired Th2 cytokine production and eosinophil recruitment during Th2-mediated responses, with no abrogation of the Th1 response. (
  • CONCLUSIONS: Mouse eotaxin is an eosinophil specific chemoattractant that has a markedly enhanced effect in vivo in the presence of another eosinophil selective cytokine IL-5, and utilizes a signal transduction receptor pathway that is distinct from that utilized by macrophage inflammatory protein-1 alpha. (
  • Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. (
  • Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis. (
  • 1995. Effect of platelet activating factor (PAF) on the migration of human lymphocytes. (
  • Activated T lymphocytes produce a variety of lymphokines that are involved in eosinophilic maturation and act as eosinophil-chemotactic factors. (
  • Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. (
  • In the mucosa away from the sites of atrophy, short bands of hyalinised collagen 15-43 μm thick, with entrapped capillaries, lymphocytes, and eosinophils (fig 2 A), were seen below the surface epithelium or at the level of the foveolae. (
  • Baggiolini M, Dewald B, Moser B. Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. (
  • The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease--1990 update. (
  • More is now known about trafficking of inflammatory cells in the skin, with specific molecular details involving various cytokines, chemotactic factors, and adhesion molecules. (
  • Eosinophils are derived from pluripotent progenitor cells in the bone marrow, and their development and differentiation are promoted by three cytokines: interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5. (
  • Organ damage typically occurs because of tissue inflammation and reaction to the cytokines and chemokines released by the eosinophils as well as to immune cells that are recruited to the tissues. (
  • In fact, an increased expression of these cytokines has been reported in nasal polyps, which can result in prolonging the survival of the migrated eosinophils within the polyp tissue. (
  • A variety of cells like epithelial cells, fibroblasts, T cells, mast cells contribute as potent sources of the above mentioned cytokines / chemokines and thus can be instrumental in orchestrating eosinophil migration. (
  • However, eosinophils themselves are an important source of some of these cytokines / chemokines (IL-5, GM-CSF, TNF-a) and are thus capable of increasing their own survival, activation and migration in an autocrine manner. (
  • Pro-inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1 are released in the early stage of allergic inflammation. (
  • Macrophages isolated from Abca1-deficient mice have an increase in cholesterol content, expression of scavenger receptors, and secretion of chemokines, growth factors, and cytokines, resulting in an increased ability to respond to a variety of chemotactic factors. (
  • These not only secrete cytokines controlling basophil, eosinophil, and mast cell activity in the orchestration of the inflammatory or allergic response, but also influence B cells to make antibody (IgE). (
  • Furthermore, several inflammatory mediators have been detected at increased concentrations within pleural effusions, including lipid mediators, cytokines and proteins (adenosine deaminase, lysosyme, eosinophil-derived cationic proteins, and products of the coagulation cascade). (
  • This compound elicited DP 2 receptor-mediated CD11b expression in human basophils and eosinophils and induced actin polymerization and migration in eosinophils with a potency about the same as that of PGD 2 . (
  • An eosinophil leukocyte chemotactic factor of anaphylaxis. (
  • ECFA may refer to: Eosinophil chemotactic factor of anaphylaxis, released from mast cell granules. (
  • Platelet activating factor (PAF) is a potent phospholipid mediator involved in anaphylaxis and chronic inflammatory disorders, including bronchial asthma. (
  • They respond chemotactically to histamine, immune complexes, and eosinophil chemotactic factor of anaphylaxis, a substance released by degranulating mast cells. (
  • Such substances include eosinophil chemotactic factor of anaphylaxis, leukotriene B4, complement complex (C5-C6-C7), and histamine (over a narrow range of concentration). (
  • A low molecular weight eosinophil chemotactic factor (ECF) which has previously been found within mast cells and polymorphonuclear cells is shown to be released from highly purified rat peritoneal macrophages on exposure to the calcium ionophore A 23187 or after phagocytosis of zymosan coated with complement (Z x). (
  • Strikingly, administration of soluble recombinant Bm- MIF-1 was able to reproduce the effects of live parasites, leading both to the up-regulation of Ym1 by macrophages and a marked recruitment of eosinophils in vivo. (
  • the resultant recombinant ( Bm- MIF-1G) was unable to induce Ym1 transcription in macrophages or to mediate the recruitment of eosinophils. (
  • These etiologic agents are phagocytosed by alveolar macrophages or bronchial epithelial cells and release chemotactic factors that recruit inflammatory cells to the lung. (
  • Inorganic dusts target alveolar macrophages, World Trade Center dust targets bronchial epithelial cells, and eosinophils characterize tropical pulmonary eosinophilia (TPE) caused by filarial organisms. (
  • The technique of bronchoalveolar lavage in humans has recovered alveolar macrophages (AMs) in dust diseases and eosinophils in TPE that release increased amounts of oxidants in vitro. (
  • IFN-γ, which was formerly called macrophage-activating factor, activates resting macrophages to kill ingested microbes by the action of nitric oxide (NO), reactive oxygen species and lysosomal enzymes. (
  • Because alveolar macrophages are normal residents of alveoli, it is likely that by releasing this factor(s) macrophages play a significant role in amplifying the inflammatory processes seen in many acute and chronic lung diseases. (
  • These changes, together with the proinflammatory condition present in ABCA1-deficient mice and increased reactivity of macrophages to chemotactic factors, play a key role in the development and progression of atherosclerosis. (
  • Indeed, the ligands for this receptor, I-309 in humans and T cell activation-specific gene 3 (TCA3) in mice, are chemotactic for Th2 cells in vitro ( 11 ). (
  • Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. (
  • Activity was tested in vitro by examining chemotactic and calcium flux responses of purified murine leukocytes. (
  • Eotaxin had no affect on the in vitro survival of eosinophils and did not induce basophil histamine release. (
  • II: 20-Hydroxy-leukotriene B4 is a potent in vivo and in vitro eosinophil chemotactic factor in nonallergic asthma. (
  • Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. (
  • The treatment of isolated human endometriosis epithelial cells with estradiol, medroxyprogesterone acetate, tumor necrosis factor-alpha, and interferon-gamma stimulated measurable eotaxin secretion into the conditioned media. (
  • In humans, dermal expression of both eotaxin/CCL11 and RANTES/CCL5 correlates with the numbers of dermal eosinophils associated with the early phases of Onchocerca volvulus infection, suggesting the importance of host expressed chemokines in directing this response [ 8 , 9 ]. (
  • The importance of chemokines is underscored by the fact that eotaxin-1/CCL11 knockout mice exhibit decreased eosinophil tissue influx and an inability to clear infection with Brugia malayi microfilariae [ 10 ]. (
  • However, eosinophil migration to the intestine is decreased but not absent in eotaxin/CCL11 knockout mice infected with Trichinella spiralis and Trichuris muris [ 11 ]. (
  • Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (
  • Interleukin 5, an eosinophil-specific growth and activating factor, and eotaxin appear to collaborate in this process. (
  • Eotaxin is a recently described chemotactic factor that belongs to the C-C (or beta) chemokine family and has been implicated in animal and human eosinophilic inflammatory states. (
  • Furthermore, intranasal or subcutaneous application of eotaxin selectively recruited large numbers of eosinophils into the mouse lung and skin, respectively, only in the presence of interleukin 5. (
  • Macrophage inflammatory protein-1 alpha, a related C-C chemokine active on eosinophils, and eotaxin were not able to cross-desensitize. (
  • Rothenberg ME, Luster AD, Leder P. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. (
  • Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. (
  • Cloning of the human eosinophil chemoattractant, eotaxin. (
  • On the other hand, the levels of chemokines like RANTES and Eotaxin which are important for eosinophil migration (Eotaxin can also contribute to tissue damage ) are also increased in the nasal polyp tissue. (
  • Neutralization of RANTES (regulated upon activation, normal T cell expressed and secreted) receptor(s) with a receptor antagonist decreases significantly lymphocyte and eosinophil infiltration as well as mRNA expression of eotaxin and RANTES. (
  • RANTES ( R egulated on A ctivation N ormal T -cells E xpressed and S ecreted) and eotaxin expression were measured using ELISA and real-time RT-PCR, eosinophil chemotactic activity (ECA) released by A549 was measured by eosinophil chemotaxis assay. (
  • Eotaxin and RANTES ( R egulated on A ctivation N ormal T -cells E xpressed and S ecreted) are C-C chemotaxins that can recruit eosinophils to the airway in asthma[ 4 ]. (
  • Although the primary function of chemokines is considered to be chemotactic, many studies suggest that they have complex regulatory functions that extend beyond leukocyte trafficking ( 2 )( 3 )( 4 )( 5 ). (
  • Additionally, desensitization of calcium flux responses to other chemokines, eosinophil survival assays, and basophil histamine release were examined. (
  • 98,% purity and then used for chemotaxis, flow cytometry, eosinophil cationic protein release assay, and survival assay. (
  • In another set of experiments, purified eosinophils incubated with various concentrations of RANTES released eosinophil cationic protein as measured by a RIA. (
  • Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. (
  • The eosinophil has characteristic specific granules that contain eosinophil peroxidase (EPO), major basic protein (MBP), and eosinophil cationic protein (ECP). (
  • Constituents of eosinophil secretory granules include a number of highly cytotoxic proteins, including eosinophil cationic protein, major basic protein, and eosinophil-derived neurotoxin. (
  • Pretreatment of eosinophils with pertussis toxin, a G protein-coupled receptor inhibitor, inhibited migration of the eosinophils to the parasite extract. (
  • The present study was conducted to delineate whether a possible mechanism for 13-(S)-hydroxyoctadecadienoic acid (13-HODE) and 15-hydroxyeicosatrienoic acid (15-HETrE) reversal of experimentally-induced skin hyperproliferation in guinea pig is via the modulation of epidermal nuclear mitogen activator protein (AP-1), a nuclear transcription factor associated with tissue turnover. (
  • Unlike the 55K protein, it binds concanavalin A. Plasma membranes were prepared from eosinophils by lysis in borate, followed by purification on a glass-bead column. (
  • Monoclonal anti-Monocyte Chemotactic Protein-1 antibody is suitable for neutralization, in which it will not neutralize the activity of recombinant human MIP-1α, recombinant mouse MIP-1α or recombinant human RANTES. (
  • Mouse anti-Monocyte Chemotactic Protein-1 antibody reacts specifically with human MCP-1/CCL2. (
  • Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting. (
  • Monocyte chemoattractant protein (MCP)-5 neutralization abolishes BHR not by affecting the accumulation of inflammatory leukocytes in the airways, but rather by altering the trafficking of the eosinophils and other leukocytes through the lung interstitium. (
  • When stimulated with mite antigens, peripheral blood mononuclear cells (PBMC) obtained from mite-sensitive asthmatics, release eosinophil chemotactic factor(s)(ECF), a type of protein. (
  • MCP3 (CCL7) is a monomeric secreted chemotactic factor of intercrine (chemokine cc) family. (
  • Production of chemoattractant molecules by the parasites could explain the presence of eosinophils in the infected tissues of mice with attenuated chemokine expression. (
  • RANTES elicited 65% of the chemotactic response to 10 -7 M platelet-activating factor in all experiments. (
  • 1981. Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons. (
  • Specific receptors of platelet-activating factor, receptor heterogeneity, and signal transduction mechanisms. (
  • 2000. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. (
  • 1997. Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. (
  • 1994. Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. (
  • 1993. Short-term and long-term role of platelet activating factor as a mediator of in vivo platelet aggregation. (
  • 1988. Histamine release from human leukocytes by platelet-activating factor. (
  • 1990. Basophil histamine release by platelet-activating factor in aspirin-sensitive subjects with asthma. (
  • These factors are active in healing wounds, chronic inflammatory conditions, retrolental fibroplasia, and malignant tumors, which require new blood vessels for continued growth. (
  • Asthma is recognised as a chronic inflammatory disease of the airways with infiltration of eosinophils and mononuclear cells into the bronchial mucosa and associated vasodilation, microvascular leakage, and epithelial disruption. (
  • This is suggested by increased numbers of activated eosinophils, as well as eosinophil derived inflammatory mediators and granule proteins in blood, induced sputum, bronchoalveolar lavage (BAL) fluid, and bronchial biopsy specimens from asthmatic subjects. (
  • PAF is able to act both, directly as a chemotactic factor and indirectly through the release of other inflammatory agents. (
  • These lesions are microscopically characterized by a diffuse, pseudoinvasive, mixed inflammatory reaction that includes large mononuclear cells, numerous eosinophils, and T cells. (
  • Moreover, the presence of cell-specific inflammatory mediators in nasopharyngeal secretions and in tracheobronchial aspirates of children with bronchiolitis suggests that RSV infection triggers the migration to the airways and local activation of eosinophil and basophil leukocytes ( 11 , 13 ). (
  • Eosinophils, while having a role as phagocytes, also have more specific functions that include providing a defense against metazoan parasites and modulating the inflammatory process. (
  • M2 cells antagonize the effects of M1 cells (mediated through IL-10), and promote tissue repair, remodeling and wound healing (through TGF-β and other factors) after inflammatory injury [ 4 , 5 ]. (
  • However, increased presence of inflammatory mediators are a prominent and common factor indicating that chronic persistent inflammation is undoubtedly a major factor in polyposis, irrespective of the etiology. (
  • 6. Gene function it controls (responsible for accumulation of eosinophils at sites of inflammation? (
  • may be responsible for accumulation of eosinophils at sites of inflammation and allergic reactions. (
  • Allergic disorders are characterized by Th2 responses against innocuous environmental factors that result in eosinophilic inflammation and the production of interleukin (IL)-4, IL-13, and IgE. (
  • Nevertheless, along with the number of blood eosinophils, serum ECP levels have been used in numerous studies to quantitate eosinophilic inflammation. (
  • Much of the cellular response at sites of tissue inflammation is controlled by gradients of chemotactic factors that direct leukocyte transendothelial migration and movement through the extracellular matrix. (
  • Inflammation (typically hypersensitivity or ectoparasites) → cellular infiltration by mast cells and eosinophils. (
  • Interestingly, TPE has massively increased eosinophils in the acute form and after treatment can still have ongoing eosinophilic inflammation. (
  • In addition to infiltrating cells, mesothelial cells have been demonstrated to actively participate in pleural inflammation via release of various mediators and proteins, including platelet-derived growth factor (PDGF), interleukin-8, monocyte chemotactic peptide (MCP-1), nitric oxide (NO), collagen, antioxidant enzymes and the plasminogen activation inhibitor (PAI). (
  • 2 Furthermore, the increased number of peripheral blood eosinophils correlates with symptoms of disease activity, and raised blood eosinophil counts have been found during nocturnal asthma. (
  • Human peripheral blood eosinophils attach to and flatten down onto antibody-coated surfaces and subsequently degranulate. (
  • Secondly, there was a tendency that neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood mononuclear cells stimulated by Candida antigen in intractable asthmatics were suppressed by OKY-046. (
  • Previous studies have demonstrated that eosinophils are accumulated in the peripheral blood, the bronchoalveolar lavage fluid, and the airway of the asthmatic patients or the allergen-sensitized animals[ 2 ]. (
  • 5. Cellular functions associated with signal (stimulates chemotaxis of eosinophils? (
  • A growth factor produced by the cell that stimulates the same cell to grow. (
  • Parasite extract stimulates multiple receptors on the eosinophil surface, which ensures a robust innate immune response to the parasite. (
  • Eosinophil trafficking is regulated by a wide variety of chemotactic factors[ 3 ]. (
  • An eosinophil with exceptionally large granules in blood from a healthy dog (Wright-Giemsa, 100X oil immersion). (
  • There is some evidence to suggest that eosinophils undergo activation during their migration to the lung, 7 and some drugs have been shown to block this activation. (
  • Prostaglandin (PG) D 2 acts through both the DP 1 receptor, which is coupled to adenylyl cyclase, and the DP 2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells), which is present on eosinophils, basophils, and Th2 cells and results in cell activation and migration. (
  • Experiments were performed to determine if an extract of S. stercoralis would trigger eosinophil chemotaxis, and to then compare the chemotactic migration response, including second messenger signals and receptors, to those mechanisms triggered by host chemoattractants. (
  • Eosinophil migration can be stimulated in either a chemokinetic (random) or chemotactic (directed) fashion after binding their ligands. (
  • Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo. (
  • The mechanism(s) whereby dyslipidemia and other atherosclerotic risk factors influence monocyte phenotype, migration, adhesion, and differentiation is less clear. (
  • 4 Serum levels of these granule proteins have been used as a tool for measuring eosinophil activation in asthma, 5 and levels can be related to disease severity 6 and the effects of treatment. (
  • May serve as a trans-acting CC binding factor directing the association of ligated target CC proteins to intermediate filaments. (
  • Our findings suggest that RFX proteins are transcription factors that contribute to the activity and lineage specificity of the IL-5Rα promoter by directly binding to a target cis element and cooperating with other tissue- and lineage-specific cofactors. (
  • Changes in eosinophil surface proteins during attachment to the antibody-coated agar layer were detected by lactoperoxidase catalysed iodination. (
  • Both the 55K and the 18K proteins were found to be major components of the eosinophil membrane. (
  • A peptide chemotactic for eosinophils and released from disrupted mast cells. (
  • It is an acidic peptide (molecular weight 500) released by mast cells, which attracts eosinophils to areas where it is present. (
  • In this study, we investigated whether RANTES could affect eosinophil chemotaxis and function. (
  • We found that RANTES is chemotactic for eosinophils at 10 -9 to 10 -8 M concentrations. (
  • We found that RANTES up-regulated the expression of CD11 b/CD18 on eosinophils in a dose-dependent manner. (
  • We also investigated the effect of RANTES on eosinophil density. (
  • Leukocytes were incubated in the presence or absence of RANTES, and the distribution of eosinophils on discontinuous Percoll gradients was then examined. (
  • However, unlike IL-3, RANTES did not affect the survival of eosinophils in a 4-day culture system. (
  • Thus, we established that RANTES is a chemotactic and activating factor for eosinophils. (
  • Expression of dominant negative mutants of these transcription factors further established their central role in virus-induced RANTES promoter activation. (
  • Our finding that the presence of multiple cis regulatory elements is required for full activation of the RANTES promoter in RSV-infected alveolar epithelial cells supports the enhanceosome model for RANTES gene transcription, which is absolutely dependent on binding of IRF transcription factors. (
  • Should the Bovine Eosinophil Chemotactic Factor (ECF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (
  • Description: A sandwich quantitative ELISA assay kit for detection of Bovine Eosinophil Chemotactic Factor (ECF) in samples from serum, plasma or other biological fluids. (
  • An eosinophil (top), a lymphocyte (center), a basophil (bottom), and normal rouleau formation of RBCs in equine blood (Wright-Giemsa, 50X oil immersion). (
  • The Eosinophil, Eosinophilia, and Eosinophil-Related Disorders III. (
  • Eosinophils, which constitute 5 to 10% of granulocytes, play an important role in host immune defense against helminthic parasites and contribute to the pathogenesis of a variety of allergic diseases associated with eosinophilia, including asthma ( 9 , 11 ). (
  • Eosinophilia has features of an immune response: an agent such as Trichinella spiralis invokes a primary response with relatively low levels of eosinophils, whereas repeated exposures result in an augmented or secondary eosinophilic response. (
  • Eosinophil disorders and related syndromes are a heterogeneous group of conditions characterized by marked persistent blood eosinophilia and involvement of one or more organ systems. (
  • In most patients with eosinophilic ulcers, trauma is the etiologic factor, and the apparent source of irritation is easily identified. (
  • The eosinophil presence is not fully understood, as most traumatic ulcers do not develop an eosinophilic infiltrate. (
  • One study demonstrated that, in most eosinophilic ulcer, the synthesis of transforming growth factor-alpha and transforming growth factor-beta is not increased in infiltrating eosinophils. (
  • 100 × 10 9 /L]), usually with eosinophilic leukemia, develop complications when eosinophils form aggregates that occlude small blood vessels, causing tissue ischemia and microinfarctions. (
  • Hereditary factors may also play an important role in the development of nasal polyposis in diseases like cystic fibrosis and ciliary dyskinesia, and this association was also reported in eosinophilic polyps. (
  • Therefore, chemoattractants derived from parasites and host species stimulate similar receptors and second messenger signals to induce eosinophil chemotaxis. (
  • Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. (
  • The specific action of IL-5 on eosinophils and hematopoietically related basophils is regulated by the restricted expression of IL-5 receptor α (IL-5Rα), a subunit of high-affinity IL-5R, on these cells. (
  • Furthermore, such knowledge has advanced even more significantly during recent years after the receptor activator of nuclear factor-κB ligand (RANKL)/RANK signaling pathway was identified as the key regulatory mechanism for osteoclastogenesis ( 3 - 6 ). (
  • Thus, the macrophage has to be added to the list of cells able to regulate eosinophil accumulation at tissue sites. (
  • In certain predisposed individuals, recurrent trauma may lead to the alteration of tissue antigens or ingress of unknown factors (eg, viral particles, toxic microbial products), which result in a hypersensitivity or allergic reaction. (
  • [ 6 ] This observation is in contrast to that of the animal wound-healing model, in which eosinophils that express transforming growth factor are typically recruited to healing tissue sites. (
  • Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin (1988) Michel Laurence et al. (
  • High levels of eosinophils in the blood can result from other conditions, too, such as drug reactions. (
  • Infections with the helminth parasite Brugia malayi share many key features with Th2-mediated allergic diseases, including recruitment of eosinophils. (
  • In this paper we present evidence for a link between the differentiation of AAMφ in response to this nematode parasite and the recruitment of eosinophils to the site of infection. (
  • In typical Th2-type allergic asthma, interleukin (IL)-4 and IL-13 predominate, driving IgE production and recruitment of eosinophils into the lungs. (
  • Genetic, behavioral, sex-specific, and environmental factors contribute to the rising incidence of allergic diseases. (
  • In conclusion, IL-5 is suggested to play an important role in increasing the functional activities of eosinophils as well as their production in allergic and parasitic diseases. (
  • Eosinophils work in allergic reactions and also against parasitic infections such as worm infestations. (
  • As the prevalence of allergic disease is increasing, probably through environmental factors, it is appropriate at this stage to review our current knowledge of the mechanisms of allergic eye disease. (
  • Eosinophil stimulation promoter ESP: A lymphokine induced by specific antigen or phytohemagglutination. (
  • An antibody-coated surface was prepared by treating a layer of agar, containing tetanus toxoid antigen and eosinophil chemotactic factor (ECF), with human anti-tetanus immunoglobin. (
  • The mechanism of Fc-mediated interaction of eosinophils with immobilized immune complexes. (
  • Numerous studies have demonstrated that various parasites synthesize molecules with the capacity to attract leukocytes, and products triggering eosinophil chemotaxis have been isolated from parasitic nematodes [ 12 , 13 ]. (
  • The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. (
  • Different cellular developmental histories, 5 microenvironmental cues, and factor-dependent polarization 6 vastly increase the complexity of macrophage phenotypes in vivo. (
  • Given evidence of autoimmune activity in the endometriosis syndrome, we hypothesized that eosinophil chemoattractants might be expressed in endometriosis. (
  • The recent molecular cloning of the complementary DNA encoding T cell--replacing factor (TRF) has demonstrated that a single molecule is responsible for B cell growth factor II (BCGF-II) activity and eosinophil differentiation activity. (
  • A whole blood automated method was developed to assess eosinophil and neutrophil activity in terms of peroxidase content and cell morphology using the Bayer haematology analyser. (
  • Supershift and microaffinity isolation assays were used to identify the different transcription factor family members whose DNA binding activity was RSV inducible. (
  • Gene(s) which might be related to eosinophil chemotactic activity were not obtained in the present experiments. (
  • Interleukin-5 (IL-5) plays a central role in the differentiation, proliferation, and functional activation of eosinophils. (
  • Whereas GM-CSF and IL-3 play necessary roles in the proliferation of all granulocyte progenitors, including eosinophils, IL-5 is specific for eosinophil differentiation, functional activation, and survival ( 30 , 47 , 48 ). (
  • Mast cell degranulation → release of eosinophil chemotactic factors. (
  • Mechanistic analyses indicated that Th2 cells developed normally and that the reduction in eosinophil recruitment was likely due to systemic reduction in interleukin 5. (
  • IL-5 maintained the viability of mature eosinophils obtained from peritoneal exudate cells of mice infected with parasites. (
  • Damage and degeneration of mucosal tissues may be due to a proliferation of cytotoxic T cells or toxic products released by degranulating eosinophils. (
  • Eosinophil chemotactic lymphokine produced by spleen cells of Schistosoma japonicum-infected mice. (
  • Several compounds released by mast cells and basophils induce IgE-mediated eosinophil production . (
  • Although many components and regulatory features of the eosinophil recruitment pathway have been elucidated ( 5 , 7 , 8 ), the molecular basis for the massive infiltration of eosinophils during helminth infection is not fully understood. (
  • The mechanism of chemotaxis was investigated by studying the expression of adhesion molecules on eosinophils by flow cytometry. (
  • BACKGROUND Asthma has been associated with eosinophil activation, measured in serum, sputum, bronchoalveolar lavage (BAL) fluid, and urine. (
  • For example, salmeterol inhibits the rise in serum ECP following allergen challenge without significantly affecting the eosinophil count. (