A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
A CXC chemokine that is chemotactic for B-LYMPHOCYTES. It has specificity for CXCR5 RECEPTORS.
A CXC chemokine that is induced by GAMMA-INTERFERON and is chemotactic for MONOCYTES and T-LYMPHOCYTES. It has specificity for the CXCR3 RECEPTOR.
A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.
A CXC chemokine that is induced by GAMMA-INTERFERON. It is a chemotactic factor for activated T-LYMPHOCYTES and has specificity for the CXCR3 RECEPTOR.
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.
Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Chemokine receptors that are specific for CXC CHEMOKINES.
A CXC chemokine that is predominantly expressed in EPITHELIAL CELLS. It has specificity for the CXCR2 RECEPTORS and is involved in the recruitment and activation of NEUTROPHILS.
CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.
CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.
CXCR receptors isolated initially from BURKITT LYMPHOMA cells. CXCR5 receptors are expressed on mature, recirculating B-LYMPHOCYTES and are specific for CHEMOKINE CXCL13.
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.
A CC chemokine with specificity for CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES and a variety of other immune cells. This chemokine is encoded by multiple genes.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A CC-type chemokine with specificity for CCR4 RECEPTORS. It has activity towards TH2 CELLS and TC2 CELLS.
A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES; and a variety of other immune cells. This chemokine is encoded by multiple genes.
A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.
A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. The membrane form of the protein may also play a role in cell adhesion.
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
The movement of cells or organisms toward or away from a substance in response to its concentration gradient.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS.
A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. It has specificity for CCR8 RECEPTORS.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.
A monocyte chemoattractant protein that attracts MONOCYTES; LYMPHOCYTES; BASOPHILS; and EOSINOPHILS. Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Heparin-binding proteins that exhibit a number of inflammatory and immunoregulatory activities. Originally identified as secretory products of MACROPHAGES, these chemokines are produced by a variety of cell types including NEUTROPHILS; FIBROBLASTS; and EPITHELIAL CELLS. They likely play a significant role in respiratory tract defenses.
A cell line derived from cultured tumor cells.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
CCR receptors with specificity for CHEMOKINE CCL17 and CHEMOKINE CCL22. They are expressed at high levels in T-LYMPHOCYTES; MAST CELLS; DENDRITIC CELLS; and NK CELLS.
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and BASOPHILS.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
CCR receptors with specificity for CHEMOKINE CCL11 and a variety of other CC CHEMOKINES. They are expressed at high levels in T-LYMPHOCYTES; EOSINOPHILS; BASOPHILS; and MAST CELLS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Adherence of cells to surfaces or to other cells.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
Established cell cultures that have the potential to propagate indefinitely.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
CCR receptors with specificity for CHEMOKINE CCL27. They may play a specialized role in the cutaneous homing of LYMPHOCYTES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
CCR receptors with specificity for CHEMOKINE CCL1. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and MACROPHAGES.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
A CC-type chemokine with specificity for CCR3 RECEPTORS. It is a chemoattractant for EOSINOPHILS.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.
Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Chemokine receptors that are specific for CC CHEMOKINES.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Group of chemokines with the first two cysteines separated by three amino acids. CX3C chemokines are chemotactic for natural killer cells, monocytes, and activated T-cells.
Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.
CCR receptors with specificity for CHEMOKINE CCL20. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Elements of limited time intervals, contributing to particular results or situations.
Soluble mediators of the immune response that are neither antibodies nor complement. They are produced largely, but not exclusively, by monocytes and macrophages.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. Included are CD4 ANTIGENS, found on T4 lymphocytes, and monocytes/macrophages, which bind to the HIV ENVELOPE PROTEIN GP120.
A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins prepared by recombinant DNA technology.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC).
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
The passage of cells across the layer of ENDOTHELIAL CELLS, i.e., the ENDOTHELIUM; or across the layer of EPITHELIAL CELLS, i.e. the EPITHELIUM.

Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (1/143)

Chemokines are a family of chemotactic peptides affecting leukocyte migration during the inflammatory response. Post-translational modification of chemokines has been shown to affect their biological potency. Here, the isolation and identification of natural isoforms of the neutrophil chemoattractants GRO alpha and GRO gamma and the epithelial-cell-derived neutrophil attractant-78 (ENA-78), is reported. Cultured tumor cells produced predominantly intact chemokine forms, whereas peripheral blood monocytes secreted mainly NH2-terminally truncated forms. The order of neutrophil chemotactic potency of these CXC chemokines was GRO alpha > GRO gamma > ENA-78 both for intact and truncated forms. However, truncated GRO alpha (4,5,6-73), GRO gamma (5-73) and ENA-78(8,9-78) were 30-fold, fivefold and threefold more active than the corresponding intact chemokine. As a consequence, truncated GRO alpha (4,5,6-73) was 300-fold more potent than intact ENA-78 indicating that both the type of chemokine and its mode of processing determine the chemotactic potency. Similar observations were made when intact and truncated GRO alpha, GRO gamma and ENA-78 were compared for their capacity to induce an increase in the intracellular calcium concentration in neutrophilic granulocytes, and to desensitize the calcium response towards the CXC chemokine granulocyte chemotactic protein-2 (GCP-2). It must be concluded that physiological proteolytic cleavage of CXC chemokines in general enhances the inflammatory response, whereas for CC chemokines NH2-terminal processing mostly results in reduced chemotactic potency.  (+info)

The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant-induced arthritis. (2/143)

The chemokine, epithelial neutrophil-activating peptide-78 (ENA-78), is a potent neutrophil chemotaxin whose expression is increased in inflamed synovial tissue and fluid in human rheumatoid arthritis compared with osteoarthritis. Since ENA-78 has been implicated in the pathogenesis of RA, we examined the expression of an ENA-78-like protein during the development of rat adjuvant-induced arthritis (AIA). Using an ELISA assay, we found increased levels of antigenic ENA-78-like protein in the sera of AIA animals compared with control normal animals by day 7 postadjuvant injection. ENA-78-like protein levels continued to increase as AIA developed. ENA-78-like protein levels in joint homogenates were increased in AIA animals later in the development of the disease, by day 18 during maximal arthritis, compared with control animals. Expression of ENA-78-like protein in both the AIA serum and joint correlated with the progression of inflammation of the joints. Anti-human ENA-78 administered before disease onset modified the severity of AIA, while administration of anti-ENA-78 after clinical onset of AIA did not modify the disease. These data support a role for an ENA-78-like protein as an important chemokine in the progression and maintenance of AIA.  (+info)

Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. (3/143)

Severe acute liver injury due to accidental or intentional acetaminophen overdose presents a major clinical dilemma often requiring liver transplantation. In the present study, liver regeneration after profound liver injury in mice challenged with acetaminophen was facilitated by the exogenous addition of ELR-containing CXC chemokines such as macrophage inflammatory protein-2 (MIP-2), epithelial neutrophil-activating protein-78 (ENA-78), or interleukin 8. Intravenous administration of ELR-CXC chemokines or N-acetyl-cysteine (NAC) immediately after acetaminophen challenge in mice significantly reduced histological and biochemical markers of hepatic injury. However, when the intervention was delayed until 10 h after acetaminophen challenge, only ELR-CXC chemokines significantly reduced liver injury and mouse mortality. The delayed addition of ELR-CXC chemokines to cultured hepatocytes maintained the proliferation of these cells in a CXCR2-dependent fashion after acetaminophen challenge whereas delayed NAC treatment did not. These observations demonstrate that ELR-CXC chemokines represent novel hepatic regenerative factors that exhibit prolonged therapeutic effects after acetaminophen-induced hepatotoxicity.  (+info)

CXC-chemokines, a new group of cytokines in congestive heart failure--possible role of platelets and monocytes. (4/143)

OBJECTIVES: The purpose of the present study was to examine the circulating levels of CXC-chemokines in patients with various degree of congestive heart failure (CHF). BACKGROUND: CXC-chemokines may be important mediators in the persistent immune activation observed in CHF patients by activation of circulating neutrophils, T-cells and monocytes and possibly by the recruitment of these cells into the failing myocardium. METHODS: Levels of interleukin (IL)-8, growth-regulated oncogene (GRO) alpha and epithelial neutrophil activating peptide (ENA)-78 were measured both in serum and in platelet-free plasma by enzyme immunoassay in 47 patients with CHF and in 20 healthy controls. RESULTS: (i) CHF patients had significantly elevated levels of all the three CXC-chemokines with IL-8 and GRO alpha showing a gradual increase along with increasing NYHA class. (ii) There was an inverse correlation between IL-8 and left ventricular ejection fraction (EF) and cardiac index (CI). (iii) Both unstimulated and lipopolysaccharide (LPS)-stimulated monocytes from CHF patients released markedly elevated amounts of all three CXC-chemokines. (iv) Platelets from patients with severe CHF were characterised by decreased content of GRO alpha and ENA-78 as well as decreased release of these chemokines upon thrombin receptor stimulation. (v) Activated platelets stimulated peripheral blood mononuclear cells in vitro to enhanced release of IL-8, and neutralising antibodies against ENA-78 inhibited this interaction. CONCLUSIONS: This study demonstrates for the first time elevated levels of CXC-chemokines in CHF, which may be of importance for progression of heart failure. Our findings further suggest that activated monocytes and platelets may contribute to enhanced CXC-chemokine levels in CHF.  (+info)

Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. (5/143)

Neutrophils migrate through endothelium using an ordered sequence of adhesive interactions and activating signals. To investigate the consequences of disruption of this sequence, we characterized adhesion and migration of neutrophils perfused over HUVEC that had been treated with TNF-alpha for 4 h and evaluated changes caused by exogenously added chemotactic agents. When HUVEC were treated with 2 U/ml TNF, flowing neutrophils adhered, with the majority rolling and relatively few migrating through the monolayer. If fMLP, IL-8, zymosan-activated plasma (a source of activated complement factor C5a), epithelial cell-derived neutrophil-activating peptide (ENA-78), or growth-regulating oncogene, GRO-alpha, was perfused over these neutrophils, they stopped rolling and rapidly migrated over the monolayer, but did not penetrate it. When HUVEC were treated with 100 U/ml TNF, the majority of adherent neutrophils transmigrated. If neutrophils were treated with fMLP, IL-8, C5a, ENA-78, or GRO-alpha just before perfusion over this HUVEC, transmigration, but not adhesion, was abolished. However, when platelet-activating factor was used to activate neutrophils, migration through HUVEC treated with 100 U/ml TNF was not impaired, and migration through HUVEC treated with 2 U/ml TNF was actually increased. Transmigration required ligation of CXC chemokine receptor-2 on neutrophils, and differential desensitization of this receptor (e.g., by fMLP but not platelet-activating factor) may explain the pattern of disruption of migration. Thus, transmigration may require presentation of the correct activators in the correct sequence, and inappropriate activation (e.g., by systemic activators) could cause pathological accumulation of neutrophils in the vessel lumen.  (+info)

Reduction of inflammatory cytokines and prostaglandin E2 by IL-13 gene therapy in rheumatoid arthritis synovium. (6/143)

The rheumatoid arthritis (RA) joint is characterized by an inflammatory synovial pannus which mediates tissue destruction. IL-13 is a cytokine that inhibits activated monocytes/macrophages from secreting a variety of proinflammatory molecules. The aim of this study was to examine whether gene therapy-delivered IL-13 could reduce the production of key proinflammatory mediators in RA synovial tissue (ST) explants. Adenoviral vectors encoding the genes for human IL-13 (AxCAIL-13) and bacterial beta-galactosidase were generated and examined for protein production. Vectors were used to infect RA ST explants and RA synovial fibroblasts, and conditioned medium (CM) was collected at various times for analysis by ELISA and competitive immunoassay. AxCAIL-13 decreased the production of RA ST explant proinflammatory IL-1beta by 85% after 24 h. Likewise, TNF-alpha levels were decreased by 82 and 75% whereas IL-8 levels were reduced 54 and 82% after 24 and 48 h, respectively, in RA ST explant CM. Monocyte chemotactic protein-1 concentrations were decreased by 88% after 72 h in RA ST explant CM. RA ST explant epithelial neutrophil-activating peptide-78 concentrations were decreased 85 and 94% whereas growth-related gene product-alpha levels were decreased by 77 and 85% at 24 and 48 h, respectively, by AxCAIL-13. Further, IL-13 significantly decreased PGE2 and macrophage inflammatory protein-1alpha production. These results demonstrate that increased expression of IL-13 via gene therapy may decrease RA-associated inflammation by reducing secretion of proinflammatory cytokines and PGE2.  (+info)

Reduced ex vivo chemokine production by polymorphonuclear cells after in vivo exposure of normal humans to endotoxin. (7/143)

Monocytes from patients with sepsis have a reduced capacity to produce cytokines, a state referred to as immunoparalysis. To determine whether polymorphonuclear leukocytes (PMNL) can be rendered hyporesponsive, PMNL from 6 healthy volunteers intravenously challenged with lipopolysaccharide (LPS; 4 ng/kg) were stimulated ex vivo with heat-killed bacteria or LPS, and the release of the CXC chemokines interleukin-8, epithelial-derived neutrophil attractant-78, and growth-related oncogen-alpha was measured. At 1 and 2 h after LPS administration in vivo, PMNL produced fewer CXC chemokines after stimulation with bacteria or LPS (all P<.05). Serum obtained 2 h after in vivo administration of LPS did not influence chemokine production by PMNL from 6 healthy volunteers not previously exposed to LPS. Thus, intravenous injection of LPS induces a refractory state of PMNL that is not caused by soluble factors produced in response to in vivo exposure to LPS.  (+info)

Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis. (8/143)

CXC chemokines are chemotactic cytokines that specifically act on neutrophils. To obtain insight into the extent of local production of CXC chemokines during acute pyelonephritis, interleukin (IL)-8, growth-related oncogene (GRO)-alpha, and epithelial cell-derived neutrophil-activating protein (ENA)-78 were measured in urine and plasma samples from patients with culture-proven urosepsis (n=33), healthy human control subjects with sterile urine (n=31), and human volunteers intravenously injected with endotoxin (n=11). Patients had profoundly elevated urine concentrations of chemokines with no (GRO-alpha and ENA-78) or little (IL-8) elevation in plasma. Endotoxin-challenged subjects demonstrated transient increases in plasma chemokine concentrations, with no (GRO-alpha) or little (IL-8 and ENA-78) elevation in urine. Urine from patients exerted chemotactic activity toward neutrophils, which was partially inhibited by neutralizing antibodies against IL-8, GRO-alpha, or ENA-78. During urosepsis, CXC chemokines are predominantly produced within the urinary tract, where they are involved in the recruitment of neutrophils to the urinary compartment.  (+info)

Buy ENA-78 elisa kit, Porcine Epithelial Neutrophil Activating Peptide 78 ELISA Kit-CAA55355.1 (MBS028798) product datasheet at MyBioSource, ELISA Kits
Our studies demonstrate that H. pylori LPS stimulates the release of both neutrophil-activating, C-X-C chemokines (IL-8 and ENA-78) and the monocyte-activating C-C chemokine MCP-1 from human monocytes. These chemokines are potent leukocyte chemoattractants and may play an important role in regulating inflammatory cell infiltration of H. pylori-infected gastric mucosa (7, 11, 14, 15,20, 21, 23, 27, 37, 40, 48). We found that H. pyloriLPS is less potent than Salmonella lipid A in inducing monocyte chemokine production. This finding agrees with previous studies showing low potency for H. pylori LPS in the induction of a wide variety of host inflammatory responses (9, 18,19, 34, 36, 38, 39, 42). However, when the actions of H. pylori LPS were specifically inhibited by using either an LPS antagonist or CD14 receptor blockade, the monocyte-activating potential of H. pylori water extract was almost completely abolished. These findings suggest that H. pylori LPS may be the primary monocyte-activating ...
HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors (statins) have been suggested to attenuate abdominal aortic aneurysm (AAA) growth. However, the effects of statins in human AAA tissues are not fully elucidated. The aim of this study was to investigate the direct effects of statins on proinflammatory molecules in human AAA walls in ex vivo culture. Simvastatin strongly inhibited the activation of nuclear factor (NF)-κB induced by tumor necrosis factor (TNF)-α in human AAA walls, but showed little effect on c-jun N-terminal kinase (JNK) activation. Simvastatin, as well as pitavastatin significantly reduced the secretion of matrix metalloproteinase (MMP)-9, monocyte chemoattractant protein (MCP)-2 and epithelial neutrophil-activating peptide (CXCL5) under both basal and TNF-α-stimulated conditions. Similar to statins, the Rac1 inhibitor NSC23766 significantly inhibited the activation of NF-κB, accompanied by a decreased secretion of MMP-9, MCP-2 and CXCL5. Moreover, the effect of
Chemokines are a large group of chemotactic cytokines that play an important pathogenic role in inflammatory diseases and autoimmune disorders by enhancement of leukocyte recruitment and activation at inflammatory sites [3-6]. ENA-78 is a CXC chemokine that attracts neutrophils during inflammation [7].. In this work, serum levels of ENA-78 were significantly higher in autistic children than healthy control children (P , 0.001). In addition, 69.35% of autistic children had increased serum levels of ENA-78. This study was the first to investigate serum levels of ENA-78 in autistic children. ENA-78 is an inflammatory C-X-C chemokine that is encoded by the CXCL5 gene [28]. Its levels are elevated in myriad inflammatory conditions [29-32].. ENA-78 is an α chemokine which is produced concomitantly with IL-8 and melanoma growth stimulating activity [7]. The main stimuli for secretion of chemokines, including ENA-78, are the early signals elicited during innate immune response such as bacterial ...
Tubular cells contribute to inflammation. The tubular epithelium is not merely a passive victim of injury but also an active participant in the inflammatory response in kidney IRI. In addition to generating proinflammatory and chemotactic cytokines such as TNF-α, MCP-1, IL-8, IL-6, IL-1β, TGF-β, RANTES, and epithelial neutrophil-activating protein 78 (ENA-78), which activate inflammatory cells (26), tubular cells also express Toll-like receptors (TLRs), complement and complement receptors, and costimulatory molecules, which regulate T lymphocyte activity (Figure 4). TLRs are a family of evolutionarily conserved transmembrane receptors and prototypic pattern recognition receptors (PRRs), which detect exogenous microbial products (37) or endogenous ligands from host material released during injury, including high-mobility group box 1, hyaluronan, and biglycan (38). During AKI, renal tubular epithelial cells express increased amounts of both TLR2 and TLR4, which modulate the degree of injury ...
Description: Description of target: C-X-C motif chemokine 5 is a protein that in humans encoded by the CXCL5 gene. The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-gamma. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on humanchromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodeling. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which ...
Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.[1][2] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.[2] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.[3][4] ...
Recombinant Human CXCL5 (ENA-78) (ELISA Std.) - CXCL5 is a member of the CXC family of chemokines, also known as epithelial activated peptide 78 (ENA-78).
CXCL5 protein is expressed in E. coli, processed, refolded and purified to yield the native, secreted form of the mature chemokine. C-X-C motif chemokine 5 (CXCL5) or epithelial-derived neutrophil-activating peptide 78 (ENA-78) is a protein that in humans
Power C.A., Furness R.B., Brawand C., Wells T.N.C. (1994). Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets.. Gene 151: 333 - 334. PubMed DOI:10.1016/0378-1119(94)90682-3 ...
IL-33 is an IL-1 family cytokine that may exert a broad spectrum of effects extending from early immune development to atopic disease exacerbations. IL-33 was initially named nuclear factor in high endothelial venules (NF-HEV) based on its high expression in the nucleus of HEVs (55). The link between IL-33 and type 2 immune responses was established when IL-33 was identified as the ligand for suppression of tumorigenicity 2 (ST2; sometimes referred to as IL-1RL1, T1, or IL-33R) (56), which had been characterized previously as an orphan receptor important in type 2 responses in the lungs (57, 58). Genetic studies have reproducibly demonstrated significant associations between IL33 and IL1RL1 genetic variants and asthma in humans (59-66). Genetic variants in IL1RL1 are also associated with AD risk (67), and genetic variants in the IL33 and IL1RL1 loci are associated with EoE risk (68, 69).. Epithelial cells at barrier surfaces and endothelial cells, both of which express IL-33 constitutively in ...
Rat CXCL5/ENA-78 ELISA Kit assay has a sensitivity of 9.375pg/ml.. Measure Rat CXCL5/ENA-78 in serum, blood, plasma, cell supernatant samples.
Neutrophil-activating protein-2 (NAP-2) is a 72 residue protein demonstrating a range of proinflammatory activities. The solution structure of monomeric NAP-2 has been investigated by two-dimensional 1H-n.m.r. spectroscopy. Sequence-specific proton resonance assignments have been made and secondary structural elements have been identified on the basis of nuclear Overhauser data, coupling constants and amide hydrogen/deuteron exchange. The NAP-2 monomer consists of a triple-stranded anti-parallel beta-sheet arranged in a Greek key and a C-terminal helix (residues 59-70) and is very similar to that found in the n.m.r. solution conformation of dimeric interleukin-8 and the crystal structure of tetrameric bovine platelet factor-4. Results are discussed in terms of heparin binding and neutrophil-activation properties of NAP-2. ...
Polymorphic markers at bovine gene loci facilitate the integration of cattle genetic maps with those of humans and mice. To this end, 31 single nucleotide polymorphism (SNP) markers were developed for seven bovine chemokine genes. Loci were amplified from bovine genomic DNA by the polymerase chain reaction, and candidate amplicons were sequenced to determine their identity. Amplified loci from 24 founding parents and select progeny from a beef cattle reference population were sequenced and analyzed for SNPs. SNP haplotype alleles were determined by examining segregation patterns and used to establish the locus position on the bovine linkage map. Loci for growth-related proteins (GRO3, GRO1, and GROX) were clustered with the related CXC chemokine genes, interleukin (IL) 8, and epithelial cell inflammatory protein 1, at 84 cM from the centromeric end of the bovine chromosome (BTA) 6 linkage group. Bovine loci for a cluster of IL8 receptors, a stromal cell-derived factor 1, interferong, and tumor necrosis
, LIX Recombinant Protein (Active), GTX48052-PRO, Applications: ELISA, WB, Functional Assay; ELISA, Western Blot (WB), Functional Assay; CrossReactivity:
Hola, me llamo Rosa y el PSP es uno de mis hobbys al que dedico parte de mi tiempo libre. Aqui encontrarás mis tags y más relacionado con el mundo del PSP. Si me sigues, gracias por hacerlo ...
Hola, me llamo Rosa y el PSP es uno de mis hobbys al que dedico parte de mi tiempo libre. Aqui encontrarás mis tags y más relacionado con el mundo del PSP. Si me sigues, gracias por hacerlo ...
小鼠CXCL5 ELISA试剂盒(GCP-2) ELISA试剂盒datasheet (ab100719).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
Matsumoto K, Kouzaki H, Kikuoka H, et al. Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33[J]. Allergology International, 2018.
Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes. Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. Biochemistry. 32 (38): 10170-7. doi:10.1021/bi00089a037. PMID 8399143. Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. ...
Chemokine ligand 5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78.
Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene.
TY - JOUR. T1 - Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages. AU - Verhoeckx, K.C.M.. AU - Doornbos, R.P.. AU - Witkamp, R.F.. AU - de Greef, J.. AU - Rodenburg, R.J.T.. PY - 2006. Y1 - 2006. N2 - Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (ß2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). LPS in combination with ß2-agonists and cAMP elevating agents had an additional effect on the release of VEGF, OSM, and CXCL6. These proteins are up-regulated after 16-24 h of exposure and this is mediated by the ß2-AR, as determined by time course experiments and the use of a specific ß2-AR antagonist (ICI ...
CXCL10 / IP10 antibody [15J7] (chemokine (C-X-C motif) ligand 10) for Neut, WB. Anti-CXCL10 / IP10 mAb (GTX53293) is tested in Mouse samples. 100% Ab-Assurance.
Book an appointment with Dr. José Félix López Martín. Find 96 verified patient reviews, where to go, insurers, prices, and treatments.
Background And Aims: The chemokine CCL20 is over-produced in epithelium of Crohns disease [CD] patients and contributes to recruiting immune cells to inflamed gut. Tumour necrosis factor-α [TNF-α] is a powerful inducer of CCL20 in intestinal epithelial cells. In CD, high levels of Smad7 block the activity of transforming growth factor-β1 [TGF-β1], a negative regulator of TNF signalling. We investigated whether intestinal epithelial cell-derived CCL20 is negatively regulated by TGF-β1 and whether Smad7 knock-down reduces CCL20 in CD ...
The U.S. Bureau of Mines studied the extraction of copper (II) from acidic sulfate solutions using commercial extractants lix 84, p5100, and pt5050. Mathematical models, consisting of sets of nonlinear mass action and mass balance equations, were solved using a commercial equation-solving program on a personal computer. The models suggest that lix 84 is a mixture of monomeric and dimeric extract
SEA080Hu, ELISA Kit for Interleukin 8 (IL8), Homo sapiens (Human), Sandwich ELISA, CXCL8, AMCF-I, GCP1, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP1, SCYB8, TSG1, B-ENAP, Neutrophil-Activating Protein 1, Granulocyte Chemotactic Protein 1, Designed by Cloud-Clone Corp.
Mhedbi-Hajri N, Hajri A, Boureau T, Darrasse A, Durand K, Brin C, Saux MF, Manceau C, Poussier S, Pruvost O, Lemaire C, Jacques MA ...
Introduction This concept identifies and briefly describes the measures of comorbidity investigated in the Cancer Data Linkage in Manitoba: Expanding the Infrastructure for Research deliverable by Lix et al. (2016). Some of these measures have been used extensively in MCHP research over time, and some are used for the first time in this research. The concept also provides links to more detailed information where available, as well as the relevant section in Lix et al. (2016) that describes the methodology for developing these measures of comorbidity ...
This abstract was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Seattle, Washington by Robert E. Marc, Felix R. Vazquez-Chona, John V. Hoang, Crystal Sigulinsky, Carl B. Watt, Bryan W. Jones, James R. Anderson and J. Scott Lauritzen. ...
Hola, me llamo Rosa y el PSP es uno de mis hobbys al que dedico parte de mi tiempo libre. Aqui encontrarás mis tags y más relacionado con el mundo del PSP. Si me sigues, gracias por hacerlo ...
[45 Pages Report] Check for Discount on C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin 8 Receptor A or IL8 Receptor Type 1 or CD181 or CXCR1) - Pipeline Review, H2 2017 report by Global Markets Direct. According to the recently published report C-X-C Chemokine...
Ischemic stroke is major cause of disability and mortality worldwide, and aging is strong risk factor for poor post-stroke outcome. Neutrophils traffic rapidly to the brain following ischemic stroke, and recent evidence has suggested that aging may alter neutrophil function after tissue injury. In this study, we hypothesize that aging enhances the pro-inflammatory function of neutrophils, directly contributing to the poorer outcomes seen in aging patients. We utilized demographic data and biological specimens from ischemic stroke patients and an experimental mouse model to determine the correlation between age, neutrophil function and stroke outcomes. In ischemic stroke patients, age was associated with increased mortality and morbidity and higher levels of neutrophil-activating cytokines. In mice, aged animals had higher stroke mortality and morbidity, higher levels of neutrophil-activating cytokines and enhanced generation of neutrophil reactive oxygen species compared to young mice. Finally,
LAA080Hu82, FITC-Linked Monoclonal Antibody to Interleukin 8 (IL8), CXCL8; AMCF-I; GCP1; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP1; SCYB8; TSG1; B-ENAP; Neutrophil-Activating Protein 1; Granulocyte Chemotactic Protein 1 | Products for research use only!
|p|Recombinant Rat CXCL1/GRO alpha/KC is a single, non-glycosylated polypeptide chain containing 72 amino acids.|/p| |p|Background: Rat CXCL1, also known as CINC-1, belongs to the CXC chemokine family. It is encoded by the GRO gene now designated CXCL1.
Read Chapter LIX of Of Human Bondage by William Somerset Maugham. The text begins: Philip passed the evening wretchedly. He had told his landlady that he would not be in, so there was nothing for him to eat, and he had to go to Gattis for dinner. Afterwards he went back to his rooms, but Griffiths on the floor above him was having a party, and the noisy merriment made his own misery more hard to bear. He went to a music-hall, but it was Saturday night and there was standing-room only: after half an hour of boredom his legs grew tired and he went home. He tried to read, but he could not fix his attention; and yet it was necessary that he should work hard. His examination in biology was ...
小鼠GRO alpha ELISA试剂盒(CXCL1) ELISA试剂盒datasheet (ab100717).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
BIENVENUE | WELCOME to our only LAtelier dArt ✪ Maïclo & Félix ~ a very special group dedicated to art in all its forms. Please visit also other great images in the group and post at least two or more comments to offer your appreciation and support. THANKS | MERCI
Éric Naggar, Actor: 3 Days to Kill. Éric Naggar was born on December 3, 1957 in Neuilly-sur-Seine, Hauts-de-Seine, France as Eric Félix Naggar. He is an actor and writer, known for 3 Days to Kill (2014), Tell No One (2006) and Mic Macs à Tire-Larigot (2009).
Moreno Izco, Fermín; Indakoetxea Juanbeltz, Begoña; Barandiaran Amillano, Miryam; Caballero, María Cristina; Gorostidi, Ana; Calafell, Francesc; Gabilondo, Alazne; Tainta, Mikel; Zulaica, Miren; Martí Massó, José Félix; López de Munain Arregui, Adolfo José; Sánchez Juan, Pascual; Lee, Suzee E. (Public Library Science, 2017-06-08) ...
Cell transplantation therapy is emerging as a promising mode of treatment following myocardial infarction. Of the various cell types that can potentially be used for transplantation, autologous skeletal myoblasts appear particularly attractive, because this would avoid issues of immunogenicity, tumorigenesis, ethics and donor availability. Additionally, skeletal myoblasts display much higher levels of ischemic tolerance and graft survival compared to other cell types. There is some evidence for improvement in heart function with skeletal myoblast transplantation. However, histological analysis revealed that transplanted myoblasts do not transdifferentiate into functional cardiomyocytes in situ. This is evident by the lack of expression of cardiac-specific antigens, and the absence of intercalated disc formation. Instead, there is differentiation into myotubes that are not electromechanically coupled to neighboring cardiomyocytes. This could in turn limit the clinical efficacy of treatment. This ...
C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) - Pipeline Review, ...
Sébastien Igonet, Marie-Christine Vaney, Clemens Vonrhein, Gérard Bricogne, Enrico A. Stura, Hans Hengartner, Bruno Eschli, and Félix A. Rey ...
Previous investigations have demonstrated a link between elevated levels of eosinophils, eosinophil activation, and adult IBD. However, there have been conflicting data regarding the individual contribution of the eosinophil-selective chemokines eotaxin-1 and eotaxin-2 in eosinophil recruitment in IBD. In the present study we demonstrate the following: 1) that eosinophil numbers are elevated in pediatric UC and that their level correlates with disease severity; 2) eotaxin-1 and not eotaxin-2 or eotaxin-3 is up-regulated in lesional colonic biopsy samples of pediatric UC patients; and 3) eotaxin-1 mRNA expression correlates with colonic eosinophil levels in pediatric UC. Using a chemical-induced colonic injury model, we define that eotaxin-1, and not eotaxin-2, is critical for eosinophil recruitment and that eotaxin-1 is predominantly derived from intestinal macrophages. Consistent with our experimental analysis, we show that eotaxin-1 is predominantly expressed by intestinal macrophages; ...
Clinical studies have demonstrated a link between the eosinophil-selective chemokines, eotaxins (eotaxin-1/CCL11 and eotaxin-2/CCL24), eosinophils, and the inflammatory bowel diseases, Crohns disease and ulcerative colitis (UC). However, the cellular source and individual contribution of the eotaxins to colonic eosinophilic accumulation in inflammatory bowel diseases remain unclear. In this study we demonstrate, by gene array and quantitative PCR, elevated levels of eotaxin-1 mRNA in the rectosigmoid colon of pediatric UC patients. We show that elevated levels of eotaxin-1 mRNA positively correlated with rectosigmoid eosinophil numbers. Further, colonic eosinophils appeared to be degranulating, and the levels positively correlated with disease severity. Using the dextran sodium sulfate (DSS)-induced intestinal epithelial injury model, we show that DSS treatment of mice strongly induced colonic eotaxin-1 and eotaxin-2 expression and eosinophil levels. Analysis of eosinophil-deficient mice ...
C-X-C Motif Chemokine 2/CXCL2/MIP-2 product information; C-X-C Motif Chemokine 2/CXCL2/MIP-2 is available 1 time from supplier EnoGene at Gentaur.com shop
Cxcl12 - Cxcl12 (untagged ORF) - Rat chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) (Cxcl12), transcript variant 3, (10 ug) available for purchase from OriGene - Your Gene Company.
Cxcl11 - Cxcl11 (Myc-DDK-tagged) - Mouse chemokine (C-X-C motif) ligand 11 (Cxcl11), transcript variant 1 available for purchase from OriGene - Your Gene Company.
Summary of CXCL8 (3-10C, AMCF-I, b-ENAP, GCP-1, GCP1, IL-8, IL8, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8, TSG-1) expression in human tissue. Cytoplasmic expression in several lymphoid tissues.
When ELRs are sent to PHA at times, they may not contain sufficient demographic, and other data as is necessary required by public health by law. While some of that data could be part of a subsequent eCR, if the data is already available at time of order and ELR transmission before an eCR is available (or the next eCR is available) helps accelerate the process.. Although ELR has been required of all laboratories performing testing for reportable conditions, only Eligible Hospital labs have been required [Andrea: this is inaccurate. EHs are NOT required to use that format. Inclusion as a Certification Criterion did not make it required. CMS MU/PI could have made it required, but did not either. It is one of the CHOICES they have. So, a number of EHRs did certify against it, even a number of LIS systems effectively did (as they are always responsible to send an ELR), but many providers did not make the choice to do so. ] (Hans, which part do you think is inaccurate and can you provide the required ...
Capitel , Sintra / Portugal....... © 2012 All rights reserved by Félix Abánades , Downloading and using without permission is illegal. Todos los derechos reservados. La descarga y uso de las fotos sin permiso es ilegal.
... role for the kinin B1 receptor and the chemokine CXCL5". Journal of Immunology. 179 (7): 4849-56. doi:10.4049/jimmunol.179.7. ... it has been shown that the kinin B1 receptor recruits neutrophil via the chemokine CXCL5 production. Moreover, endothelial ... cells have been described as a potential source for this B1 receptor-CXCL5 pathway.[11] ...
... role for the kinin B1 receptor and the chemokine CXCL5". J. Immunol. 179 (7): 4849-56. doi:10.4049/jimmunol.179.7.4849. PMC ...
Role for the Kinin B1 Receptor and the Chemokine CXCL5". The Journal of Immunology.. ... Nedavno je bilo pokazano da kinin B1 receptor regrutuje neutrofile putem produkcije hemokina CXCL5. Endotelne ćelije su bile ... opisane kao potentni izvori tog B1 receptor-CXCL5 puta.[8]. *B2 receptor je konstitutivno izražen i učestvuje u bradikininovoj ...
DARC has also been linked to rheumatoid arthritis (RA), possibly displaying chemokines such as CXCL5 on the surface of ... It mediates chemokine transcytosis, which leads to apical retention of intact chemokines and more leukocyte migration. Binding ... "Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of ... "Expression of chemokines and chemokine receptors during human renal transplant rejection". Am. J. Kidney Dis. 37 (3): 518-31. ...
"Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX ...
... is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on ... In addition, it binds ligands CXCL2, CXCL3, and CXCL5. The angiogenic effects of IL8 in intestinal microvascular endothelial ... Brandt E, Ludwig A, Petersen F, Flad HD (Oct 2000). "Platelet-derived CXC chemokines: old players in new games". Immunological ... Ahuja SK, Lee JC, Murphy PM (Jan 1996). "CXC chemokines bind to unique sets of selectivity determinants that can function ...
... scyb4 CXCL5: chemokine (C-X-C motif) ligand 5, scyb5 CXCL6: chemokine (C-X-C motif) ligand 6, scyb6 CXCL7: chemokine (C-X-C ... chemokine (C-X-C motif) ligand 1, scyb1 CXCL2: chemokine (C-X-C motif) ligand 2, scyb2 CXCL3: chemokine (C-X-C motif) ligand 3 ... chemokine (C-X-C motif) ligand 9, scyb9 CXCL10: chemokine (C-X-C motif) ligand 10, scyb10 CXCL11: chemokine (C-X-C motif) ... ligand 11, scyb11 CXCL13: chemokine (C-X-C motif) ligand 13, scyb13 CYTL1: Cytokine-like 1 DCUN1D4: Defective in cullin ...
Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 CXCL10 CXCL11 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CXCL2 CXCL3 CXCL5 CXCL6 ... Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... 7 Calreticulin Cancer immunology Cancer immunoprevention Cancer immunotherapy Cantuzumab ravtansine Cathelicidin CC chemokine ...
C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene. The protein encoded by this ... 2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a ... The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. ... "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5". Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and ...
CXCL5. Scyb5. ENA-78. CXCR2. P42830 CXCL6. Scyb6. GCP-2. CXCR1, CXCR2. P80162 ... C chemokinesEdit. The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... CC chemokinesEdit. The CC chemokine (or β-chemokine) proteins have two adjacent cysteines (amino acids), near their amino ...
chemokine receptor activity. • receptor activity. • protein binding. • C-C chemokine receptor activity. • C-C chemokine binding ... Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[5] CCR6 ... "Entrez Gene: CCR6 chemokine (C-C motif) receptor 6".. *^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, ... "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
CXCL5 (англ. C-X-C motif chemokine ligand 5) - білок, який кодується однойменним геном, розташованим у людей на короткому плечі ... Sepuru K.M., Poluri K.M., Rajarathnam K. (2014). Solution structure of CXCL5--a novel chemokine and adipokine implicated in ... chemokine-mediated signaling pathway. • cell chemotaxis. • neutrophil mediated immunity. • Хемотаксис. • defense response. • ... Struyf S., Proost P., Van Damme J. (2003). Regulation of the immune response by the interaction of chemokines and proteases.. ...
Other molecular signals for megakaryocyte differentiation include GM-CSF, IL-3, IL-6, IL-11, chemokines (SDF-1, FGF-4). and ... Other signals such as PF4, CXCL5, CXCL7, and CCL5 inhibit platelet formation. Megakaryocytes are directly responsible for ... "Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis ...
CXCL1 · CXCL2 · CXCL3 · CXCL4 · CXCL5 · CXCL6 · CXCL7 · CXCL8/IL8 · CXCL9 · CXCL10 · CXCL11 · CXCL12 · CXCL13 · CXCL14 · CXCL15 ... Chemokine. CCL. CCL1 · CCL2 · CCL3 · CCL4 · CCL5 · CCL6 · CCL7 · CCL8 · CCL9 · CCL11 · CCL12 · CCL13 · CCL14 · CCL15 · CCL16 · ...
positive regulation of chemokine (C-X-C motif) ligand 2 production. • positive regulation of JUN kinase activity. • positive ... positive regulation of chemokine production. • cellular extravasation. • negative regulation of lipid storage. • negative ... positive regulation of chemokine biosynthetic process. • epithelial cell proliferation involved in salivary gland morphogenesis ...
... s are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte.[1] They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells. Lymphokines have many roles, including the attraction of other immune cells, including macrophages and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response. Circulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is required. Lymphokines aid B cells to produce antibodies. Important lymphokines secreted by the T helper cell include:[2] ...
... binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is caspase-8-dependent. Caspase-8 activates downstream effector caspases including procaspase-3, -6, and -7, leading to activation of specific kinases.[11] TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation. Application of engineered ligands that have variable affinity for different death (DR4 and DR5) and decoy receptors (DCR1 and DCR2) may allow selective targeting of cancer cells by controlling activation of Type 1/Type 2 pathways of cell death and single cell fluctuations. Luminescent iridium complex-peptide ...
... (IL-24) is a protein that in humans is encoded by the IL24 gene. IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells[5] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer.[6][7][8] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[9][10] The gene for IL-24 is located on chromosome 1 in humans.[11] ...
... as well as chemokine and cytokine production, and expression of adhesion molecules such as E-selectin, ICAM-1, and VCAM-1. This ...
positive regulation of chemokine biosynthetic process. • regulation of insulin secretion. • extrinsic apoptotic signaling ... Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12 ...
... is sometimes used interchangeably among scientists with the term cytokine.[3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes). For the circulatory system and bone marrow in which cells can occur in a liquid suspension and not bound up in solid tissue, it makes sense for them to communicate by soluble, circulating protein molecules. However, as different lines of research converged, it became clear that some of the same signaling proteins which the hematopoietic and immune systems use were also being used by all sorts of other cells and tissues, during development and in the mature organism. While growth factor implies a positive effect on cell division, cytokine is a neutral term with respect to whether a molecule affects proliferation. While some cytokines can be growth factors, such as G-CSF and GM-CSF, others have an inhibitory effect on ...
chemokine activity. • cytokine activity. • heparin binding. • protein binding. • CXCR3 chemokine receptor binding. ... C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T- ... "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11".. *^ a b Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue ... This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a ...
Interferon alfa 2b is an antiviral or antineoplastic drug, that was originally discovered in the laboratory of Charles Weissmann at the University of Zurich. It was developed at Biogen, and ultimately marketed by Schering-Plough under the tradename Intron-A. It has been used for a wide range of indications, including viral infections and cancers. This drug is approved around the world for the treatment of chronic hepatitis C, chronic hepatitis B, hairy cell leukemia, Behçet's disease, chronic myelogenous leukemia, multiple myeloma, follicular lymphoma, carcinoid tumor, mastocytosis and malignant melanoma. ...
4-1BB is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, expressed on activated T Lymphocytes.[1] 4-1BBL (4-1BB ligand) is found on APCs (antigen presenting cells) and binds to 4-1BB. ...
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[8]. ...
C-X-C chemokine receptor activity. • interleukin-8 binding. • G-protein coupled receptor activity. • chemokine receptor ... This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 ... "Chemokine Receptors: CXCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... chemokine-mediated signaling pathway. • interleukin-8-mediated signaling pathway. • neutrophil degranulation. • chemotaxis. ...
Inggris)Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks ... CXCL2 dan CXCL5 pada otak[11] - yang meningkat pada granulosit seiring dengan migrasi, pada model tikus, terbukti menurunkan ... "A protective role for ELR+ chemokines during acute viral encephalomyelitis.". Department of Molecular Biology and Biochemistry ...
Cxcl5 chemokine (C-X-C motif) ligand 5 [Mus musculus] Cxcl5 chemokine (C-X-C motif) ligand 5 [Mus musculus]. Gene ID:20311 ... Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME) Chemokine receptors bind chemokines, organism- ... Cxcl5provided by MGI. Official Full Name. chemokine (C-X-C motif) ligand 5provided by MGI. Primary source. MGI:MGI:1096868 See ... Cxcl5 chemokine (C-X-C motif) ligand 5 [ Mus musculus (house mouse) ] Gene ID: 20311, updated on 12-Aug-2018 ...
Cxcl5 chemokine (C-X-C motif) ligand 5 [ Mus musculus ]. Synonyms:. Cxcl5; chemokine (C-X-C motif) ligand 5; LIX; GCP-2; Scyb5 ... Recombinant Murine Chemokine (C-X-C Motif) Ligand 5, 70aa. Download Datasheet See All Cxcl5 Products. Bring this labeled ... CXC Chemokines and Receptors Proteins CXCL1 CXCR4 CXCL5 CXCR3 CXCR5 CXCR6 CXCL17 LIX1L ... Cxcl5-97M)Recombinant Murine Chemokine (C-X-C Motif) Ligand 5, 70aa ...
C-X-C motif chemokine 5 protein (CXCL5) Active Protein-NP_002985.1 (MBS969186) product datasheet at MyBioSource, Active ... Chemokine Signaling Pathway antibodies. Chemokine Signaling Pathway Diagram. Chemokine Signaling Pathway antibodies. Chemokine ... Chemokine Receptors Bind Chemokines Pathway antibodies. Chemokine Receptors Bind Chemokines Pathway Diagram. ... NCBI Summary for CXCL5. This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which ...
Compare C-X-C motif chemokine ligand 5 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations ... CXCL5/LIX, BioAssay™ ELISA Kit (Rat) (C-X-C Motif Chemokine 5) ... chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic *. ... C-X-C motif chemokine ligand 5 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based ... Your search returned 288 C-X-C motif chemokine ligand 5 ELISA ELISA Kit across 26 suppliers. ...
Compare C-X-C motif chemokine ligand 6 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations ... Rat C-X-C Motif Chemokine 5 / ENA-78 (CXCL5) ELISA Kit ... C-X-C motif chemokine ligand 6 ELISA Kits. The ELISA (enzyme- ... Your search returned 98 C-X-C motif chemokine ligand 6 ELISA ELISA Kit across 20 suppliers. ...
CXCL5, in prostate cancer. The main goal of this study is to determine the role of the angiogenic chemokine, CXCL5, in prostat ... CXCL5, in prostate cancer. The main goal of this study is to determine the role of the angiogenic chemokine, CXCL5, in prostate ... CXCL5 is a member of CXC family of chemokines with the three amino acid motif, glutamic acid-leucine-arginine (ELR+) and is a ... Role of the Angiogenic Chemokine, CXCL5, in Prostate Cancer Simon, Liz Tuskegee University, Tuskegee, AL, United States ...
Chemokines and proteinases. Human CCL2/MCP-1, CCL8/MCP-3, CCL7/MCP-2, CCL13/MCP-4, CXCL1/Groα, CXCL2/Groβ, CXCL3/Groγ, CXCL5/ ... MMP-12 processing of human ELR+ CXC chemokines. All 7 of the human ELR+ CXC chemokines tested were processed by human MMP-12 ... MMP-1 and -9 processing of human ELR+ CXC chemokines. The ELR motif in ELR+ CXC chemokines is crucial in cognate receptor ... MMP-12 processing of the murine CXCL5 chemokine. Infiltrating monocytes, macrophages, and tissue-resident activated macrophages ...
This review will focus on recent murine and human studies that use chemokines as therapeutic anti-cancer vaccine adjuvants. ... Recent discoveries in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing ... This knowledge, combined with advances in gene therapy and virology, allows researchers to employ chemokines as potential ... CXCL5. ENA-78. CXCR2. inflammatory and angiogenic. CXCL6. GCP-2. CXCR1, CXCR2. inflammatory and angiogenic. ...
The sets consist of the following chemokines: 6Ckine/CCL21, Axl, BTC, CCL28, CTACK/CCL27, CXCL16, ENA-78/CXCL5, Eotaxin-3/CCL26 ... i,Results.,/i, We showed possible implication of 4 chemokines, that is, HCC-4, I-TAC, MIP-3,i,α,/i,, and TARC in women with ... i,Conclusion.,/i, On the basis of our findings, it seems that the chemokines may play role in the pathogenesis of preterm labor ... The aim of the study was to determine the concentration of selected chemokines in sera of patients with premature birth without ...
CXCL5. Scyb5. ENA-78. CXCR2. P42830 CXCL6. Scyb6. GCP-2. CXCR1, CXCR2. P80162 ... C chemokinesEdit. The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... CC chemokinesEdit. The CC chemokine (or β-chemokine) proteins have two adjacent cysteines (amino acids), near their amino ...
c) Type II pneumocytes positive for CXCL5. (d) Alveolar macrophages positive for CXCL5. ... To determine if the influence of pseudomonas isolation and ELR(+) CXC chemokines on the subsequent development of BOS and the ... The likelihood of transition from transplant to BOS was increased by acute rejection, CXCL5, and the interaction between ... Immunohistochemistry sections from patients with recent pseudomonas infections stained for CXCL1 and CXCL5. (a) CXCL1 ...
PeproTechs chemokines include proteins that act through G protein-coupled receptors and conform to the prototypical chemokine ... Recombinant Human ENA-78 (CXCL5) (5-78 a.a.). 0 Review(s) ... Chemokines possess high levels of specificity; a trait that ... Chemokine Subfamilies and Nomenclature. C Chemokines - Contain only two conserved cysteine residues linked by a single ... Chemokines and their receptors otherwise tend to interact indiscriminately to stimulate upregulation of adherent chemokines, co ...
PeproTechs chemokines include proteins that act through G protein-coupled receptors and conform to the prototypical chemokine ... Recombinant Human ENA-78 (CXCL5) (8-78 a.a.). Numéro Catalogue: 300-22B ...
... Posted on June 24, 2019. by techuniq ... C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful ... CXCL5 may have an important role in the occurrence and progression of tumors by cooperating with its receptor C-X-C chemokine ... 9) reported that high expression of C-X-C motif chemokine ligand (CXCL) 8 in ovarian cancer epithelial cells resulted in an ...
Sex differences in neutrophil kinetics were correlated with sustained induction of chemokine Cxcl5 in the tissue, circulation, ... Our study reveals that sex-specific induction of chemokine Cxcl5/CXCL6 contributes to sexual dimorphism in neutrophil ... implicating a greater sensitivity of male leukocytes to Cxcl5-mediated activation. Differential induction of Cxcl5 (human CXCL6 ... Conversely, administration of Cxcl5 to males in the absence of I/R was sufficient to increase levels of systemic neutrophils. ...
CXCL5. ENA-7. CXCR2. N. ND. CXCL6. GCP-2. CXCR1, CXCR2. N, M. ND. ... the CXC chemokines CXCL8, CXCL9, CXCL10, CXCL12; and CX3CL1. This set represented all chemokines present in the chemokine ... Generally, CC chemokines potently attract monocytes, T lymphocytes, eosinophils, and basophils, whereas CXC chemokines are ... Differences between our study and previous studies, chemokine function, and chemokine levels are summarized in Table 4. Before ...
... whereas most CXC chemokines without the ELR motif bind to CXCR3 and lead to vascular inhibition (80). For example, the CXCL5/ ... Among the four types of chemokines, there are two highly homologous XC chemokines: XC motif chemokine ligand 1 (XCL1) and XCL2 ... Chemokine receptors. Chemokines. Functions. Signaling pathways. Role in HCC. (Refs.). CXCR1. CXCL6,. Chemotactic neutrophils. - ... chemokines can bind to the atypical chemokine receptor (ACKR) subfamily, which is a key regulator of the chemokine network, and ...
Although the expression of CXC chemokines was modestly up-regulated in ECs, the expression of CXCL1, CXCL5, and CXCL8 was ... Expression of the chemokine transporter Duffy antigen receptor for chemokines (DARC) is also up-regulated in early RA. The aim ... Anti-CXCL5 antibody abolished neutrophil recruitment by neutralizing CXCL5 expressed on ECs or when used to immunodeplete ... The roles of CXCL5 and DARC were determined by incorporating cocultures into a flow-based adhesion assay, in which their ...
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX ...
Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of ... Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of ...
Chemokines and their receptors play essential roles in immunology during inflammation and in homeostasis. ... Chemokines are a class of secreted molecules that induce chemotaxis (migration) of target cells. ... CXCL5. b. a. b. b. b. b. b. b. b. b. b. b. b. b. b. b. b. b. b. ... Chemokine Receptor Biology poster. Order your copy of our ... Chemokines are also involved in the orchestration of wound healing.. For more information on inflammatory chemokines, see the ...
CXCL5. Scyb5. ENA-78. P42830 CXCL6. Scyb6. GCP-2. P80162 CXCL7. Scyb7. NAP-2, CTAPIII, β-Ta, PEP. P02775 ... C chemokines. The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... CC chemokines. The CC chemokines (or β-chemokines) have two adjacent cysteines near their amino terminus. There have been at ...
CXCL5. CCR1. GNG3. TIAM1. CCL19. PF4. PRKCZ. RAP1A. NFKB1. MAPK1. AC006486.9. ARRB1. PRKACG. Gm4356. VAV2. CXCR3. PXN. PTK2. ... Chemokines are small cytokines, or signaling proteins, secreted by cells. A major rol of chemokines is to act as ... c-C motif chemokine 12-like. CXCL12. CCR1. CX3CR1. GNG2. DOCK2. RAC1. GNB4. Jak-STAT signaling pathway. CCR2. PIK3R2. HRAS. ... Ontology Term : chemokine mediated signaling pathway added !. 90740. view. 23:30, 13 December 2016. Khanspers. New pathway. ...
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010;33(1):106-117.. View ... Prostate cancer growth in bone vossicles is hindered in CXCL5-/- mice. (A) WT (CXCL5+/+) and CXCL5-/- recipient mice (7wk males ... vossicles from CXCL5-/- mice were inoculated with the RM1-iC9 cells and implanted in CXCL5-/- mice. Similarly, WT (CXCL5+/+) ... CXCL5 deficiency hinders tumor growth and bone osteolysis in the intratibial model. Both WT (n = 8) and CXCL5-/- (n = 7) mice ...
C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene. The protein encoded by this ... 2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a ... The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. ... "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5". Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and ...
Buy our Recombinant human CXCL5 protein. Ab73316 is an active full length protein produced in Escherichia coli and has been ... C-X-C motif chemokine ligand 5. *chemokine (C-X-C motif) ligand 5 ... Recombinant human CXCL5 protein. See all CXCL5 proteins and ...
It binds the chemokines CXCL1, CXCL2 and CXCL5. "We have seen that the concentration of the chemokines in the bone marrow, ... IFN-beta interferes with this communication: it makes the cells in the tumour produce fewer chemokines and no chemokine ... Neutrophils migrate along the chemokine gradient into the tumour and once there, they themselves release the same chemokines in ... Neutrophils normally circulate in the blood until--attracted by so-called chemokines--they enter the tissue where they ingest ...
Ausgesuchte Qualitäts-Hersteller für CXCL5 Antikörper. Hier bestellen. ... Monoklonale und polyklonale CXCL5 Antikörper für viele Methoden. ... Target Chemokine (C-X-C Motif) Ligand 5 (CXCL5) * Chemokine (C-X-C Motif) Ligand 5 (CXCL5) ... anti-CXCL5 Antikörper (Chemokine (C-X-C Motif) Ligand 5) (AA 45-118) Primary Antibody CXCL5 Reaktivität: Maus ICC, IHC, WB Wirt ...
CXCL5/ENA-70 (aa 45-114). Human. 649-EN. 0.15-0.75 ng/ml. ... CXCL5/ENA-74 (aa 41-114). Human. 651-NA. 0.3-1.5 ng/ml. ... Available Chemokines and the Effect of Modification. Recombinant Chemokines (amino acids). Species. Catalog Number. Effect of ... Browse our complete line of chemokine-related products. View Larger. Fig. 1 Recombinant Human CXCL1/GRO alpha chemoattracts ... New Chemokines Expressed in Mammalian Cell Lines. Recombinant Protein. Species. Source. Catalog Number. ...
  • This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. (nih.gov)
  • LIX is a CXC chemokine that signals through the CXCR2 receptor. (creativebiomart.net)
  • CXCL5 binds to its putative receptor, CXCR2, initiates signaling and has been implicated in cancers of lung (non-small), colorectum and prostate. (grantome.com)
  • We are particularly interested in the expression pattern of CXCL5 and its receptor, CXCR2, in the preinvasive stages of the disease. (grantome.com)
  • The aims of the present study are to a) determine the expression of CXCL5 and its receptor, CXCR2, in prostatic tissues with and without neoplastic lesions b) determine if CXCL5 secreted by prostate cancer cells regulates the expression of vascular endothelial growth factor, a growth factor essential for angiogenesis c) determine if genistein, can inhibit angiogenesis and invasiveness of prostate cancer cells and if it is mediated through CXCL5. (grantome.com)
  • MMP-12 specifically cleaves human ELR + CXC chemokines (CXCL1, -2, -3, -5, and -8) at E-LR, the critical receptor-binding motif or, for CXCL6, carboxyl-terminal to it. (bloodjournal.org)
  • In the context of cancer, the chemokine-chemokine receptor system plays paradoxical roles. (mdpi.com)
  • Most chemokines bind to more than one receptor, while most receptors also display overlapping ligand specificity [ 5 ]. (mdpi.com)
  • The biological functions of chemokines rely mainly on their receptors, a type of G protein-coupled receptor that mediates the functions of chemokines and is usually expressed in immune cells and endothelial cell membrane. (techuniq.com)
  • Murakami (12) indicated that C-X-C chemokine receptor type 4 is an essential molecular determinant for the metastatic accumulation of tumor cells in the lungs of mice. (techuniq.com)
  • The tumor homing hypothesis also showed that the specific combination of the chemokine ligand and its receptor is sufficient to initiate tumor metastasis (13). (techuniq.com)
  • Additionally, CXCL5 may have an important role in the occurrence and progression of tumors by cooperating with its receptor C-X-C chemokine receptor type 2 (CXCR2) (14C16). (techuniq.com)
  • Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium. (ox.ac.uk)
  • Expression of the chemokine transporter Duffy antigen receptor for chemokines (DARC) is also up-regulated in early RA. (ox.ac.uk)
  • In order to exert biological effect, chemokines will bind with receptors of the G-protein coupled receptor (GPCR) superfamily, which possess seven conserved transmembrane domains with which chemokines can interact. (peprotech.com)
  • Chemokines bind to a variety of different receptors, which belong to the G-protein-binding receptor family, and there are ~23 types of chemokine receptors that have been discovered ( 10 ). (spandidos-publications.com)
  • CXCL5 is an inflammatory cytokine which binds to the cell surface receptor CXCR2 and induces chemotaxis of neutrophils to a target site. (biolegend.com)
  • It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. (wikipedia.org)
  • Use this table to quickly identify the chemokines that bind to each receptor. (biolegend.com)
  • Naturally occurring modifications, such as N-terminal truncation, can affect the biological potency and the receptor specificity of chemokines. (rndsystems.com)
  • The present investigation demonstrated that CXCL5 was expressed in both hepatoblastoma HepG2 cells and liver stellate LX‑2 cells, and CXCL5's receptor C‑X‑C chemokine receptor type 2 (CXCR2) was expressed in HepG2 cells by reverse transcription‑polymerase chain reaction (RT‑PCR), western blotting and ELISA assays. (spandidos-publications.com)
  • [10] Most recently, it has been shown that the kinin B 1 receptor recruits neutrophil via the chemokine CXCL5 production. (wikipedia.org)
  • Moreover, endothelial cells have been described as a potential source for this B 1 receptor-CXCL5 pathway. (wikipedia.org)
  • As a CXC-type chemokine, ENA78/CXCL5 is an important attractant for granulocytes by binding to its receptor CXCR2. (dovepress.com)
  • Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins. (semanticscholar.org)
  • GO annotations related to this gene include heparin binding and CXCR chemokine receptor binding . (genecards.org)
  • Unlike most chemokines whose function and expression are specific and centered around their role in leukocyte trafficking, both stromal cell-derived factor 1/CXCL12 and its first identified receptor CXCR4 were found to be expressed in a wide variety of cell types and tissues ( 3 ). (jimmunol.org)
  • PDF] Chemokine receptor CXCR4 expression and lung cancer prognosis: a meta-analysis. (semanticscholar.org)
  • The chemokine receptor CXCR4 is a G protein-coupled receptor that plays an important role in several biological processes, such as trafficking and homeostasis of immune cells (like T lymphocytes), alteration of cell skeleton rearrangement and cell migration. (semanticscholar.org)
  • Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. (semanticscholar.org)
  • Chemokine activity is controlled at different levels, including regulation of chemokine and chemokine receptor expression, the presence of "silent" or "decoy" chemokine receptors, binding to GAG, and posttranslational modification ( 9 - 13 ). (rupress.org)
  • [7] . Nedavno je bilo pokazano da kinin B 1 receptor regrutuje neutrofile putem produkcije hemokina CXCL5 . (wikipedia.org)
  • Endotelne ćelije su bile opisane kao potentni izvori tog B 1 receptor-CXCL5 puta. (wikipedia.org)
  • LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. (creativebiomart.net)
  • However, it has been demonstrated that tumor cells express chemokine receptors and/or their ligands that facilitate tumor cell survival, growth and migration. (grantome.com)
  • Chemokines and their receptors play a number of non-redundant roles in cancer angiogenesis, invasiveness, and metastasis. (grantome.com)
  • To date, there are more than 50 chemokines and 18 chemokine receptors identified [ 6 ]. (mdpi.com)
  • All of these proteins exert their biological effects by interacting with G protein -linked transmembrane receptors called chemokine receptors , that are selectively found on the surfaces of their target cells. (wikipedia.org)
  • a trait that enables the recruitment of diverse populations of well-defined chemokine subsets and receptors. (peprotech.com)
  • Classified into subfamilies based on the motifs of their ligands, these receptors tend to interact with the chemokines of their eponymous subfamilies. (peprotech.com)
  • Chemokines and their receptors otherwise tend to interact indiscriminately to stimulate upregulation of adherent chemokines, co-stimulatory cytokines and signaling cascades that polarizes cells to direct chemotaxis. (peprotech.com)
  • It has been found that chemokines and their receptors serve a pivotal role in HCC progression. (spandidos-publications.com)
  • Thus, chemokines and their receptors directly or indirectly shape the tumor cell microenvironment, and regulate the biological behavior of the tumor. (spandidos-publications.com)
  • Exosomes containing chemokines or expressing receptors for chemokines may improve chemotaxis to HCC and may thus be exploited for targeted drug delivery. (spandidos-publications.com)
  • Chemokines and their receptors were initially thought to allow for an interaction between immune cells and the inflammatory sites ( 11 ). (spandidos-publications.com)
  • After binding to the receptors, chemokines primarily serve a role in migration of leukocytes, such as monocytes, eosinophils and dendritic cells (DCs) ( 11 ). (spandidos-publications.com)
  • The chemokine receptors CXCR1/2 are involved in a variety of inflammatory diseases, including chronic obstructive pulmonary disease. (aspetjournals.org)
  • The results also point to several potential therapeutic approaches, including the inhibition of chemokines or their receptors, Moses said. (scienceblog.com)
  • Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)
  • Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)
  • Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (wikipathways.org)
  • CXCL5 is produced by various human epithelial cells and it binds to the same receptors as IL8 and NAP2. (thermofisher.com)
  • With respect to neutrophil chemoattractants and receptors, counts of CXCL5, CXCL8, CXCR1 and CXCR2 mRNA-positive cells in the subepithelium of the E-asthma group were, respectively, 5, 4, 4 and 18 times greater (p⩽0.01) than those of the NSC group. (bmj.com)
  • Neutrophil accumulation in tissue is partly a result of chemoattraction by neutrophil chemokines including interleukin-8 (also known as CXCL8) and epithelial-derived neutrophil attractant-78 (also known as CXCL5) via actions on cell surface receptors, specifically CXCR1 and CXCR2. (bmj.com)
  • 11- 14 In severe exacerbations of chronic obstructive pulmonary disease (COPD), neutrophil recruitment to the bronchial mucosa occurs which is associated with upregulation of CXCL5, CXCL8 and receptors CXCR1 and CXCR2. (bmj.com)
  • Chemokines exhibit affinity for seven transmembrane-spanning G protein-coupled signaling receptors and extracellular matrix or cell-bound glycosaminoglycans (GAGs). (rupress.org)
  • CXCL8 promotes in vivo activation and recruitment of neutrophil granulocytes through the chemokine receptors 1 and 2 (CXCR1 and CXCR2) ( 7 , 8 ). (rupress.org)
  • Cervical tissue was collected at 3, 12, and 24 h after inoculation and the expression array of chemokines, cytokines, and receptors was assessed to characterize the response during the initial developmental cycle. (asm.org)
  • MMPs accomplish these varied tasks by acting on a variety of protein substrates, such as antimicrobial peptides, adhesion proteins, receptors, cytokines, chemokines and extracellular-matrix proteins. (nature.com)
  • Your search returned 288 C-X-C motif chemokine ligand 5 ELISA ELISA Kit across 26 suppliers. (biocompare.com)
  • C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. (techuniq.com)
  • 9) reported that high expression of C-X-C motif chemokine ligand (CXCL) 8 in ovarian cancer epithelial cells resulted in an increased proliferation rate SCH 900776 irreversible inhibition compared with low expression of CXCL8 in the cells. (techuniq.com)
  • Cxcl5 treatment of bone marrow neutrophils in vitro caused substantial induction of neutrophil-mobilizing cytokine granulocyte colony-stimulating factor (GCSF) and expression of β2 integrin that accounts for sexual dimorphism in circulating neutrophil populations in I/R. Moreover, male Cxcl5-stimulated bone marrow neutrophils had an increased capacity to adhere to β2 integrin ligand ICAM-1, implicating a greater sensitivity of male leukocytes to Cxcl5-mediated activation. (biomedcentral.com)
  • 101 Chemokine (C-X-C Motif) Ligand 5 (CXCL5) Antikörper von 15 Herstellern verfügbar auf www.antikoerper-online.de. (antikoerper-online.de)
  • CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. (genecards.org)
  • This review focuses on the recent development of biomarkers for assessing the efficacy of anti-PD1 antibodies using routine blood tests such as the neutrophil-to-lymphocyte ratio, eosinophil ratio, serum markers such as lactate dehydrogenase, programmed cell death ligand 1 (PD-L1) expression on melanoma cells, microsatellite instability and mismatch repair deficiency assays, as well as soluble CD163, and tumor-associated macrophage-related chemokines (e.g. (frontiersin.org)
  • Infection occurring at the start of the rest period leads to higher mortality than infection at the start of the active period and is associated with increased numbers of inflammatory cells and higher levels of chemokine (C-C motif) ligand 2 (CCL2). (pnas.org)
  • The lower survival rate in these mice was associated with higher levels of circulating chemokine (C-C motif) ligand 2 (CCL2), a greater number of peripherally derived immune cells accumulating in the olfactory bulb (OB), and increased production of proinflammatory cytokines, indicating an immune-mediated pathology. (pnas.org)
  • In conclusion, the present findings indicate that CXCL5/CXCR2 axis contributes to the oncogenic potential of hepatoblastoma via autocrine or paracrine pathways by regulating expression of genes associated with the progression of carcinoma. (techuniq.com)
  • The data presented here describe the cellular pharmacology of the acid and ester forms of the nicotinamide glycolate pharmacophore, a potent antagonist of CXCR2 signaling by the chemokines CXCL1 and CXCL8. (aspetjournals.org)
  • Recent studies proved that CXCL5/CXCR2 axis plays an oncogenic role in many human cancers. (dovepress.com)
  • CXCL5 and CXCR2 have an association with eosinophila only, and these represent potentially new targets for treatment in exacerbations of asthma. (bmj.com)
  • In addition, they also revealed that a cell signaling pathway called Hippo-Yap1 regulated the protein Cxcl5, which was identified as a cancer-secreted chemokine that attracted or "recruited" MDSCs, which expressed another protein, Cxcr2. (mdanderson.org)
  • For example, in addition to chemotaxis, chemokines modulate lymphocyte development, priming and effector function [ 2 ] and play a critical role in immune surveillance. (mdpi.com)
  • In addition to being known for mediating chemotaxis, chemokines are all approximately 8-10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikipedia.org)
  • Representing the largest class of cytokines, chemokines play an essential role in both physiological and pathological activities by stimulating the migration of certain leukocytes through concentration gradients in a process known as chemotaxis. (peprotech.com)
  • In addition, the potential application of chemokines in chemotaxis of exosomes as drug vehicles is discussed. (spandidos-publications.com)
  • This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. (wikipedia.org)
  • Chemokines are a class of cytokines that induce chemotaxis (migration) of target cells. (biolegend.com)
  • While some chemotaxis is induced by inflammation or damaged cells, other chemokines function in homeostasis. (biolegend.com)
  • In addition to their function in chemotaxis, chemokines can induce various activation progressions in physiology through their effects on regulating angiogenesis, cellular proliferation, differentiation and apoptosis ( 6 - 8 ). (spandidos-publications.com)
  • Chemokines are essential to stimulate chemotaxis of leukocytes and initiate inflammatory responses ( 1 , 2 ). (frontiersin.org)
  • Once at the site of injury, immune cells can react by releasing additional cytokines and chemokines, bringing more cells into the fold. (biolegend.com)
  • Here, we tested the hypothesis that hitherto unrecognized cytokines and chemokines might act as mediators in inflammatory pain. (sciencemag.org)
  • In addition, neutrophils are capable of producing many cytokines and chemokines, which can influence the inflammatory response, as well as the immune response [ 4 , 5 ]. (hindawi.com)
  • The various antimicrobial and cytotoxic compounds contained in granules can destroy malignant cells, and cytokines and chemokines secreted by neutrophils can also recruit other cells with antitumor activity [ 5 , 9 ]. (hindawi.com)
  • Cytokines and chemokines were quantified in homogenized lung. (nih.gov)
  • Lastly, lung and blood and plasma cytokines and chemokines were correlated with each other. (nih.gov)
  • Infection with H. pylori is associated with an infiltration of neutrophils, macrophages, eosinophils, and lymphocytes to the site of inflammation, mediated through the induction of cytokines and chemokines ( 21 , 36 ). (asm.org)
  • Conversely, administration of Cxcl5 to males in the absence of I/R was sufficient to increase levels of systemic neutrophils. (biomedcentral.com)
  • Our study reveals that sex-specific induction of chemokine Cxcl5/CXCL6 contributes to sexual dimorphism in neutrophil recruitment in diverse acute inflammatory responses partly due to increased stimulation and trafficking of bone marrow neutrophils in males. (biomedcentral.com)
  • Inflammatory chemokines function mainly as chemoattractants for leukocytes , recruiting monocytes , neutrophils and other effector cells from the blood to sites of infection or tissue damage. (wikipedia.org)
  • Neutrophils normally circulate in the blood until--attracted by so-called chemokines--they enter the tissue where they ingest and destroy intruding pathogens. (eurekalert.org)
  • We have seen that the concentration of the chemokines in the bone marrow, where the neutrophils originate, is low," says Dr Siegfried Weiss, head of the department in which Jablonska-Koch works. (eurekalert.org)
  • Neutrophils migrate along the chemokine gradient into the tumour and once there, they themselves release the same chemokines in order to attract other neutrophils to obtain more support. (eurekalert.org)
  • CXCL5 is expressed by fibroblasts, is induced by bacterial lipopolysaccharides, and is chemotactic for neutrophils. (abcam.com)
  • CXCL5 chemoattracts and activates neutrophils during inflammation, and it is induced by LPS and inflammatory cytokines. (biolegend.com)
  • This hypersensitivity was associated with the infiltration of neutrophils and macrophages into the dermis, and neutralizing the effects of CXCL5 attenuated the abnormal pain-like behavior. (sciencemag.org)
  • Furthermore, at the wound site, MMP7 sheds chemokine-bound syndecan-1, a transmembrane proteoglycan, which in turn guides the transepithelial influx of neutrophils. (nature.com)
  • Chemokines (Greek -kinos , movement) are a family of small cytokines , or signaling proteins secreted by cells . (wikipedia.org)
  • Cytokine proteins are classified as chemokines according to behavior and structural characteristics. (wikipedia.org)
  • The invasion of such matter generates an onslaught of inflammatory responses, recruiting several immune cells and proteins, including a special class of small cytokines called chemokines. (peprotech.com)
  • Chemokines are a class of small molecular proteins with similar structures, functions and chemotactic properties, and their molecular weights are ~10 kDa, and chemokines represent the largest member of the cytokine family ( 9 ). (spandidos-publications.com)
  • Chemokines are a family of small cytokines , or proteins secreted by cells . (wikidoc.org)
  • Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikidoc.org)
  • Proteins are classified into the chemokine family based on their structural characteristics, not just their ability to attract cells. (wikidoc.org)
  • Typical chemokine proteins are produced as pro-peptides , beginning with a signal peptide of approximately 20 amino acids that gets cleaved from the active (mature) portion of the molecule during the process of its secretion from the cell. (wikidoc.org)
  • Chemokines are small cytokines, or signaling proteins, secreted by cells. (wikipathways.org)
  • Chemokines are small secreted proteins that function in leukocyte trafficking, recruitment, and activation and have a role in many pathophysiological processes such as infectious and autoimmune diseases, inflammation, cancer, and vascular disease. (rndsystems.com)
  • Chemokines are a family of small secreted proteins that activate and attract leukocytes during inflammation, but also play an important role in normal leukocyte trafficking, including lymphocyte homing. (rupress.org)
  • Indeed, as we discuss here, recent findings indicate that matrix metalloproteinases act on pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity. (nature.com)
  • The molecule, called CXCL5, is part of a family of proteins called chemokines, which recruit inflammatory immune cells to the injured tissue, triggering pain and tenderness. (fiercebiotech.com)
  • Although the expression of CXC chemokines was modestly up-regulated in ECs, the expression of CXCL1, CXCL5, and CXCL8 was greatly increased in RASFs. (ox.ac.uk)
  • This study shows that PAD citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation. (rupress.org)
  • CXCL8 (IL-8), which contains the tripeptide Glu-Leu-Arg (ELR) in front of the first Cys residue, is an inflammatory CXC chemokine with potent neutrophil chemotactic and angiogenic properties ( 3 - 6 ). (rupress.org)
  • In an attempt to better understand such discrepancies, we studied alternatively modified chemokines and discovered a novel natural posttranslational modification of CXCL8, i.e., the conversion of one specific Arg into Cit. (rupress.org)
  • Unfractionated heparin and LMWHs attenuated the TNF-α-mediated induction of CXCL8 and enhanced CXCL5, CCL2, and CCL5. (sigmaaldrich.com)
  • Some inflammatory chemokines have proven essential in memory T cell generation [ 3 ]. (mdpi.com)
  • Certain inflammatory chemokines activate cells to initiate an immune response or promote wound healing . (wikipedia.org)
  • These chemokines also have a more diverse range of functions compared to inflammatory chemokines. (biolegend.com)
  • In the event of infection, injury, or tissue damage, inflammatory chemokines are often released to address the problem. (biolegend.com)
  • Many inflammatory chemokines attract a wide variety of cells in both the innate and adaptive arms of immunity. (biolegend.com)
  • Thus, this study aimed to evaluate levels of inflammatory chemokines in RhD − pregnant women with erythrocyte alloimmunization. (frontiersin.org)
  • Thus, analysis of inflammatory chemokines could provide a better understanding of the pathogenesis of maternal erythrocyte alloimmunization. (frontiersin.org)
  • Immunohistochemistry sections from patients with recent pseudomonas infections stained for CXCL1 and CXCL5. (nih.gov)
  • particularly, the expression of chemokines CXCL1 and CXCL5. (scienceblog.com)
  • Regulation of CXCL1 and CXCL5 secretion by IL-17 and TGF- β . (aacrjournals.org)
  • B , tumor explant was prepared as described in the Methods and analyzed for CXCL1 and CXCL5 by ELISA (R&D Systems). (aacrjournals.org)
  • C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene. (wikipedia.org)
  • This gene encodes a protein that is a member of the CXC subfamily of chemokines. (nih.gov)
  • Small volumes of CXCL5 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
  • After the initial PMN influx, the next stage of inflammation is directed in part by CC chemokines consisting of CCL2/monocyte chemoattractant protein (MCP)-1, CCL7/MCP-3, CCL8/MCP-2, and CCL13/MCP-4, which target multiple leukocyte subsets (monocytes, T lymphocytes, basophils, and eosinophils). (bloodjournal.org)
  • The results revealed that overexpression of CXCL5 regulated the expression of several genes, including N-myc downregulated gene 3,w B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein, P53, vascular endothelial growth factor, interleukin (IL)-18, IL-1 and cystathionine-lyase. (techuniq.com)
  • The induction of potent chemoattractive mediators (chemokines) and neutrophil adhesion molecules were measured by real-time PCR, flow cytometry, and protein assays. (biomedcentral.com)
  • The precursor of CXCL5 contains 114 amino acids, with a signal peptide of 36 amino acids which is cleaved to generate the 78 amino acid mature protein (8 kD). (biolegend.com)
  • To measure human CXCL5, this recombinant protein can be used as a standard in a sandwich ELISA format, when used in conjunction with the purified J1119G12 antibody (Cat. (biolegend.com)
  • The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). (wikipedia.org)
  • Intramolecular disulphide bonds typically join the first to third, and the second to fourth cysteine residues, numbered as they appear in the protein sequence of the chemokine. (wikidoc.org)
  • The first two cysteines, in a chemokine, are situated close together near the N-terminal end of the mature protein, with the third cysteine residing in the centre of the molecule and the fourth close to the C-terminal end . (wikidoc.org)
  • Here, we found that the serum protein expression of CXCL5 was significantly increased in non-small cell lung cancer (NSCLC) compared with that in healthy volunteers. (dovepress.com)
  • Immunohistochemistry staining revealed that CXCL5 protein was higher in various lung cancer tissues compared with normal tissues. (dovepress.com)
  • Elevated CXCL5 protein abundance predicted poor overall survival in adenocarcinoma patients. (dovepress.com)
  • The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. (bio-rad.com)
  • Using a mouse ( Mus musculus ) model of asthma applied to the Collaborative Cross population, we previously identified a lung gene expression quantitative trait locus (eQTL) for Zinc finger protein 30 ( Zfp30 ) that was also a QTL for neutrophil recruitment and the hallmark neutrophil chemokine CXCL1. (g3journal.org)
  • While a function of chemokines is to regulate lymphocyte trafficking, the view that chemokines act simply as "chemotactic cytokines" has evolved to include the many critical roles they play in regulating innate and adaptive immune responses. (mdpi.com)
  • Chemokines are a family of small molecular weight cytokines, which are involved in leukocytes stimulation and chemotactic gradient determining. (hindawi.com)
  • NH2-terminal truncation enhances, whereas citrullination decreases the chemotactic properties of CXCL5. (biolegend.com)
  • CXCL5 is well known to have chemotactic and activating functions on neutrophil, mainly during acute inflammatory responses. (wikipedia.org)
  • In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). (genecards.org)
  • These chemotactic cytokines contain conserved cysteine residues in their amino (NH 2 )-terminal structure, a characteristic used for classification into CXC, CC, CX 3 C, and C chemokines ( 1 , 2 ). (rupress.org)
  • By contrast, others chemokines are regulated by MMP cleavage of substrates that bind, retain and concentrate the chemotactic molecules in particular locations: that is, they establish chemokine gradients. (nature.com)
  • Classified into subfamilies by the structural conservation of both cysteine residues and disulfide bonds, chemokine nomenclature reflects several cysteine-grouping motifs and arrangements. (peprotech.com)
  • C Chemokines - Contain only two conserved cysteine residues linked by a single disulfide bond. (peprotech.com)
  • CC Chemokines - Contain four conserved cysteine residues of which the first two, closest to the N-terminal, are adjacent to one another. (peprotech.com)
  • CXC Chemokines - Contain four conserved cysteine residues of which the first two, closest to the N-terminal, are separated by a single amino acid. (peprotech.com)
  • To date, >50 chemokines have been found, which can be divided into four families: CXC, CX3C, CC and XC, according to the different positions of the conserved N‑terminal cysteine residues. (spandidos-publications.com)
  • 50 chemokines have been identified, which can be divided into four families: CXC, CX3C, CC and XC, based on the different positions of the conserved N-terminal cysteine residues ( 9 ). (spandidos-publications.com)
  • All chemokines share a typical Greek key structure that is stabilised by disulphide bonds between conserved cysteine residues. (wikidoc.org)
  • According to the order of conserved cysteine residues, chemokines are classified as C, CC, CXC and C (X) 3 C. Additionally, CXC chemokines are further grouped into ELR + CXC and ELR − CXC on the basis of the presence or absence of the amino-terminal ELR motif ( 5 ). (spandidos-publications.com)
  • Chemokines are small cytokines, structurally characterized by conserved cysteine residues and first described for their ability to control leukocyte migration under basal and inflammatory conditions ( 1 , 2 , 3 , 4 ). (jimmunol.org)
  • Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone. (nih.gov)
  • Recent discoveries in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing recruitment of antigen presenting cells (APCs) and effector cells to appropriate anatomical sites. (mdpi.com)
  • As an efficient mediator of angiogenesis, the expression of CXCL5 in non-small cell lung cancer was associated with angiogenesis, which is vitally important in the proliferation, invasion and metastasis of tumor cells (10). (techuniq.com)
  • Chemokines are involved in the inflammatory response, tumor immune response, proliferation, invasion and metastasis via modulation of various signaling pathways. (spandidos-publications.com)
  • This chemokine is produced concomitantly with Interleukin 8 (IL8) in response to stimulation with either Interleukin 1 (IL1) or Tumor Necrosis Factor alpha (TNFA). (abcam.com)
  • The signature also points to chemokines as important mediators of TGF-β's effects on tumor growth. (scienceblog.com)
  • CXCL5 is the main chemokine attracting MDSC to the primary tumor. (mendeley.com)
  • It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine. (google.com)
  • Moreover, CXCL5 expression correlated with histological grade, tumor size, and TNM stage in NSCLC. (dovepress.com)
  • Further meta-analysis demonstrated that CXCL5 mRNA expression was also positively associated with tumor stage, lymph node metastasis, and worse survival. (dovepress.com)
  • Heparin modulates chemokines in human endometrial stromal cells by interaction with tumor necrosis factor α and thrombin. (sigmaaldrich.com)
  • Treatment of tumor-bearing mice with chemotherapy induced intratumoral expression of these chemokines and favored T-cell infiltration into cutaneous tumors. (aacrjournals.org)
  • In patients with melanoma, these chemokines were also upregulated in chemotherapy-sensitive lesions following chemotherapy, and correlated with T-cell infiltration, tumor control, and patient survival. (aacrjournals.org)
  • T-cell recruitment to the tumor is one of the potential rate-limiting steps in immunotherapy, and thus, intratumoral chemokines are likely to have a major impact ( 11, 12 ). (aacrjournals.org)
  • Identify Cxcl5 as a novel target of AHR-mediated gene expression in primary mouse keratinocytes. (nih.gov)
  • NCBI/Uniprot data below describe general gene information for CXCL5 . (mybiosource.com)
  • This knowledge, combined with advances in gene therapy and virology, allows researchers to employ chemokines as potential vaccine adjuvants. (mdpi.com)
  • The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. (wikipedia.org)
  • Human CXCL5 genome location and CXCL5 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • To explore the autocrine and paracrine roles of CXCL5 in the oncogenic potential of HepG2 cells, HepG2 cells overexpressing CXCL5 and LX‑2 cells overexpressing CXCL5 were successfully constructed by gene transfection. (spandidos-publications.com)
  • An important paralog of this gene is CXCL5 . (genecards.org)
  • RPE cells co-cultured with EC exhibited increased gene expression of CXCL5, COX1, MMP2, IGF1, and IL8, all of which are involved in both angiogenesis and inflammation. (molvis.org)
  • Gene expression profiling studies have shown that intratumoral expression of chemokines, indeed, correlate with T-cell infiltration ( 13 ). (aacrjournals.org)
  • These data identify suppression of CXCL2 and CXCL5 chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury. (nih.gov)
  • Chemokines are an important class of chemoattractant cytokines produced locally in tissues that provide the directional cues for the movement of blood-derived leukocytes in development, homeostasis, and inflammation. (bloodjournal.org)
  • The initial phase of inflammation involves a subset of CXC chemokines, which rapidly attract PMNs. (bloodjournal.org)
  • Chronic inflammation is characterized by aberrant long-term expression of circulating inflammatory factors such as chemokines, cytokines, and growth factors. (aacrjournals.org)
  • Posttranslational proteolytic processing of chemokines is a natural mechanism to regulate inflammation. (jimmunol.org)
  • In particular, several MMPs regulate the activity of chemokines, either directly or indirectly, thereby controlling many aspects of inflammation and immunity. (nature.com)
  • Anti-CXCL5 antibody abolished neutrophil recruitment by neutralizing CXCL5 expressed on ECs or when used to immunodeplete coculture-conditioned medium. (ox.ac.uk)
  • This assay employs an antibody specific for Rat CXCL5 coated on a 96- well plate. (abcam.com)
  • Standards and samples are pipetted into the wells and CXCL5 present in a sample is bound to the wells by the immobilized antibody. (abcam.com)
  • The wells are washed and biotinylated anti-Rat CXCL5 antibody is added. (abcam.com)
  • The following antibody was used in this experiment: CXCL5 Recombinant Polyclonal Antibody (9HCLC) from Thermo Fisher Scientific, catalog # 710010, RRID AB_2532523. (thermofisher.com)
  • Cytokine antibody array analysis revealed that koPFCM had more than two-fold elevation in granulocyte colony-stimulating factor and CXCL1, CXCL16, and CXCL5 expression relative to wtPFCM. (aacrjournals.org)
  • Further tests carried out on the rats showed that a neutralising antibody targeting CXCL5 significantly reduced the sensitivity to pain caused by the UVB irradiation. (fiercebiotech.com)
  • In pregnancy, chemokines are potent mediators of embryogenesis and neoangiogenesis and important for the recruitment of macrophages and NK, dendritic, and T cells to maternal decidua ( 1 , 2 ). (frontiersin.org)
  • CXCL5 is a member of CXC family of chemokines with the three amino acid motif, glutamic acid-leucine-arginine (ELR+) and is a potent angiogenic promoter. (grantome.com)
  • This chemokine is a potent chemotaxin involved in neutrophil activation. (abcam.com)
  • This may be important in that dietary antiangiogenic products such as genistein may act by regulation of this chemokine signaling pathway. (grantome.com)
  • We propose that the macrophage, specifically through MMP-12, assists in orchestrating the regulation of acute inflammatory responses by precise proteolysis of ELR + CXC and CC chemokines. (bloodjournal.org)
  • On the other hand, the chemokine system also plays a crucial role in the induction of antitumor immune responses and optimal effector function regulation of immune cells [ 1 , 4 , 5 ]. (mdpi.com)
  • Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. (semanticscholar.org)
  • Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. (semanticscholar.org)
  • Heparins have modulating effects on TNF-α- and thrombin-induced endometrial chemokines, which might have implications in the regulation of endometrial receptivity and early implantation. (sigmaaldrich.com)
  • The major role of chemokines is to act as a chemoattractant to guide the migration of cells. (wikipedia.org)
  • OBJECTIVE: The role of chemokines and their transporters in rheumatoid arthritis (RA) is poorly described. (ox.ac.uk)
  • The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. (google.com)
  • This invention relates to antibodies or the use of antibodies directed against certain chemokines. (google.com)
  • Some chemokines are considered pro- inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection , while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development . (wikipedia.org)
  • A major rol of chemokines is to act as chemoattractants in guiding migration of cells. (wikipathways.org)
  • Cell counting kit‑8, colony formation and Transwell assays revealed that exogenous CXCL5 expression efficiently promoted proliferation, colony formation and migration of HepG2 cells. (spandidos-publications.com)
  • Similarly, overexpression of CXCL5 in HepG2 also enhanced proliferation, colony formation and migration of HepG2 cells. (spandidos-publications.com)
  • Furthermore, the condition medium of LX‑2 cells overexpressing CXCL5 affected the proliferation and migration of HepG2 cells. (spandidos-publications.com)
  • Differential induction of Cxcl5 (human CXCL6) between the sexes was also evident in murine renal I/R, rat pleurisy, and human skin blisters and correlated with the magnitude of neutrophil accumulation in tissues. (biomedcentral.com)
  • Sex differences in neutrophil kinetics were correlated with sustained induction of chemokine Cxcl5 in the tissue, circulation, and bone marrow of males but not females. (biomedcentral.com)
  • Evidence suggests that CXCL5 plays an important role, because it is abundant in RA tissue, and its neutralization moderates joint damage in animal models of arthritis. (ox.ac.uk)
  • Abcam's CXCL5 Rat ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Rat CXCL5 cell lysate and tissue lysate. (abcam.com)
  • CXCL5 has been implicated in connective tissue remodelling. (wikipedia.org)
  • Further studies of serum chemokines and placenta tissue could provide a better understanding of the cells involved in the pathogenesis of maternal erythrocyte alloimmunization. (frontiersin.org)
  • There have been numerous in vitro studies showing that chlamydiae can elicit various chemokines and cytokines from tissue culture cells (reviewed in reference 19 ). (asm.org)
  • We intend to investigate the role of CXCL5 in angiogenesis of prostate cancer cells and approaches to inhibit this signaling pathway. (grantome.com)
  • This pathway was inferred from Mus musculus pathway "Chemokine signaling pathway", WP2292 revision 89521, with a 91.0% conversion rate. (wikipathways.org)
  • For measuring human CXCL5 in serum, plasma or cell culture supernatant, LEGEND MAX™ Human CXCL5 ELISA Kit with Pre-coated Plates (Cat. (biolegend.com)
  • It has been found that chemokine networks may serve pivotal roles in inducing organ-specific metastasis ( 8 ). (spandidos-publications.com)
  • Due to their function of targeting cells to specific organs, homeostatic chemokines can also be involved in cancer and metastasis. (biolegend.com)
  • The roles of CXCL5 and DARC were determined by incorporating cocultures into a flow-based adhesion assay, in which their function was demonstrated by blocking neutrophil recruitment with neutralizing reagents. (ox.ac.uk)
  • These data identify the induction of intratumoral expression of chemokines as a novel cell-extrinsic mechanism of action of chemotherapy that results in the recruitment of immune cells with antitumor activity. (aacrjournals.org)
  • Chemokines are chemoattractive small molecules that were initially discovered to be involved in recruitment and trafficking of leucocytes to inflammatory sites. (grantome.com)
  • Messenger molecules such as chemokines are a means of communication frequently used for this purpose. (eurekalert.org)
  • The researchers hypothesize that molecules called chemokines mediate the signaling between glial cells and immune cells, after identifying increased levels of a chemokine called CXCL5 in the brains of flu-infected mice. (medicalnewstoday.com)
  • Examination of biopsy samples taken from human patients before and after anti-angiogenic therapy revealed that expression of these chemokines - molecules that attract immune cells - increased in response to anti-VEGF treatment. (eurekalert.org)
  • They all also possess conserved amino acids that are important for creating their 3-dimensional or tertiary structure , such as (in most cases) four cysteines that interact with each other in pairs to create a Greek key shape that is a characteristic of chemokines. (wikidoc.org)
  • The LEGENDplex™ Human Proinflammatory Chemokine Standard product is intended for use with the Mix and Match Human Proinflammatory Chemokine Panel of products. (biolegend.com)
  • RT-PCR and western blotting assays were also conducted to explore whether overexpression of CXCL5 in HepG2 modulated the expression of genes. (techuniq.com)
  • Several chemokine and cytokine genes were expressed as early as 3 h after infection, but by 12 h, 41 genes were expressed. (asm.org)
  • The recruitment of F4/80 + cells correlated with increased expression of known inflammatory genes including Cxcl1, Cxcl5 , and Ptgs2 (cyclooxygenase-2). (aacrjournals.org)
  • The genes for IL-8 , as well as PTGS2 , TPR , JUN , CXCL1 , CXCL3 , CXCL5 and PARD3 were highly expressed in schizophrenia patients. (dovepress.com)
  • Chemokines are a group of related chemoattractant peptides that are essential regulators of the immune system, both during homeostatic and inflammatory conditions. (mdpi.com)
  • On one hand, the chemokine network is used by tumors to evade immune surveillance, resist apoptosis, and metastasize. (mdpi.com)
  • Some chemokines control cells of the immune system during processes of immune surveillance, such as directing lymphocytes to the lymph nodes so they can screen for invasion of pathogens by interacting with antigen-presenting cells residing in these tissues. (wikipedia.org)
  • Critical to maintaining hemostasis through hematopoietic differentiation and immune surveillance, chemokines also help orchestrate both innate and adaptive immune responses. (peprotech.com)
  • Chemokine-triggered immune responses often require co-stimulation by primary proinflammatory cytokines, such as IL-1α, IFN-γ and TNF-α. (peprotech.com)
  • Chemokines are members of the cytokine super family and are secreted by various cell types, including immune, mesothelial, endometrial glandular and stromal cells, and trophoblasts ( 4 ). (spandidos-publications.com)
  • Neutrophil chemokines (CXCL1, CXCL5) were quantified in plasma, but CXCL2 was not detectable. (nih.gov)
  • From right to left, molecular features are grouped as follows: T-cell cytokines (IL-2, IFN-γ), macrophage cytokines (IL-12, TNF, IL-10) and neutrophil chemokines (CXCL1, CXCL5, CXCL2). (nih.gov)
  • CXCL5 is a member of the CXC family of chemokines, also known as epithelial activated peptide 78 (ENA-78). (biolegend.com)
  • CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. (semanticscholar.org)
  • Proteolytic processing regulates cytokine and chemokine activities. (rupress.org)
  • Second, unlike human ELR + CXC chemokines, mCXCL5 (LPS-induced CXC chemokine [LIX]) was not inactivated. (bloodjournal.org)
  • This review will focus on recent murine and human studies that use chemokines as therapeutic anti-cancer vaccine adjuvants. (mdpi.com)
  • Previous studies have shown that overexpression of CXCL5 is present in numerous human tumors including prostate, squamous cell and stomach tumors. (techuniq.com)
  • CONCLUSION: This study is the first to demonstrate, in a model of human disease, that the function of DARC is essential for editing the chemokine signals presented by ECs and for promoting unwanted leukocyte recruitment. (ox.ac.uk)
  • Recombinant Human ENA-78 (CXCL5) (5-78 a.a. (peprotech.com)
  • Recombinant Human CXCL5 ENA-78 ELISA Std. (biolegend.com)
  • This is the rat homolog of human CXCL5 . (guidetopharmacology.org)
  • To study the impact of heparins on chemokines in decidualized human endometrial stromal cells (ESCs) in vitro. (sigmaaldrich.com)
  • We found that dacarbazine, temozolomide, and cisplatin induced expression of T-cell-attracting chemokines in several human melanoma cell lines in vitro . (aacrjournals.org)
  • The mediator CXCL5 was significantly over-expressed in the human biopsies and the biology of this chemokine in rats, which suggests it is responsible for a significant amount of sensitivity in the sunburn. (fiercebiotech.com)
  • Fig. 3 depicts the cytokine and chemokine data for each class of DO mice (supersusceptible, susceptible, resistant and non-infected) and for the C57BL/6J founder strain for comparison. (nih.gov)
  • Lung cytokine and chemokine correlations with survival were nearly identical to those for the other indicators (not shown). (nih.gov)
  • Interleukin (IL)-6, a multifunctional cytokine with regulatory functions in wound healing, and several chemokines have been implicated in the pathogenesis of proliferative vitreoretinopathy (PVR) after rhegmatogenous retinal detachment (RRD). (arvojournals.org)
  • later observed that chlamydial infection of epithelial cells in vitro resulted in the production of interleukin 8 (IL-8), an important chemokine for PMNs, 20 to 24 h postinfection and required that the organisms be viable ( 26 ). (asm.org)
  • CXCL5 drives neutrophil recruitment in TH17-mediated GN. (nih.gov)
  • Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. (nih.gov)
  • The aim of this study was to investigate the role of CXCL5 and DARC in regulating neutrophil recruitment, using an in vitro model of RA synovium. (ox.ac.uk)
  • In this study, we describe modification of the CXC chemokine stromal cell-derived factor 1α/CXCL12 by peptidylarginine deiminase (PAD) that converts arginine residues into citrulline (Cit), thereby reducing the number of positive charges. (jimmunol.org)
  • In conclusion, modification of CXCL12 by one Cit severely impaired the CXCR4-mediated biologic effects of this chemokine and maximally citrullinated CXCL12 was inactive. (jimmunol.org)
  • CXCL5 is required for angiogenesis, but not structural adaptation after small bowel resection. (nih.gov)
  • Although CXCL5 is expressed by prostate cancer cells, its role in angiogenesis and prostate cancer progression has not been established. (grantome.com)
  • The central hypothesis is that CXCL5 plays a significant role in the progression of prostate cancer possibly via increased angiogenesis. (grantome.com)
  • Various chemokines and IL-6 are upregulated in patients in whom fibrotic membranes develop after primary RRD repair and may therefore be involved in the future development of postoperative PVR. (arvojournals.org)
  • There has been a great deal of work published on the induction of various chemokines and cytokines using in vitro culture systems. (asm.org)
  • In addition to IL-17, Th17 cells produce IL-17F, IL-22, IL-26, TNFα and various chemokines [ 25 - 27 ], which act in concert to mediate the pro-inflammatory effects of this population. (pubmedcentralcanada.ca)
  • These are known as homeostatic chemokines and are produced and secreted without any need to stimulate their source cell(s). (wikipedia.org)
  • Homeostatic chemokines are constitutively expressed in particular organs or tissues. (biolegend.com)
  • Understanding the mechanisms of angiogenic chemokine signaling pathways and approaches to inhibit these pathways will help to develop therapeutic strategies to inhibit or prevent prostate cancer progression. (grantome.com)
  • Cancer and chemokine signaling pathways were enriched in the schizophrenic group, related to the high expression of IL-8 . (dovepress.com)
  • CXCL5, a member of the subfamily of proangiogenic chemokines, is implicated in the progression of several cancer types. (grantome.com)
  • CXCL5 is a member of the CXC subfamily of chemokines. (thermofisher.com)
  • The likelihood of transition from transplant to BOS was increased by acute rejection, CXCL5, and the interaction between pseudomonas and CXCL1. (nih.gov)
  • These cysteines provide tertiary structure for the chemokine through disulfide bonds. (biolegend.com)