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Chemokine CXCL12Chemokine CXCL13Chemokine CXCL10Chemokine CXCL6Chemokine CXCL11Chemokine CXCL1Chemokine CXCL9Chemokines, CXCReceptors, ChemokineReceptors, CXCRChemokine CXCL5Receptors, CXCR4Receptors, CXCR3ChemokinesChemokine CCL5Receptors, CXCR5Receptors, Interleukin-8BChemokine CCL2Chemokine CXCL2Chemokine CCL21Chemotaxis, LeukocyteChemokine CCL4Cell MovementChemokine CCL22Chemokine CCL3Chemokine CCL17Receptors, ScavengerChemokine CCL19Chemokine CX3CL1Chemokines, CCInterleukin-8Heterocyclic CompoundsChemotaxisMice, Inbred C57BLPlatelet Factor 4Chemokine CCL7Chemokine CCL20Cells, CulturedChemokine CCL11Chemokine CCL1Neutrophil InfiltrationSignal TransductionChemokine CCL27Mice, KnockoutUp-RegulationFlow CytometryReceptors, CCR2Receptors, CCR1RNA, MessengerReceptors, CCR5Chemokine CCL8CytokinesInflammationGene Expression RegulationMacrophage Inflammatory ProteinsCell Line, TumorReverse Transcriptase Polymerase Chain ReactionEnzyme-Linked Immunosorbent AssayReceptors, CCR4Receptors, Interleukin-8AMice, Inbred BALB CT-LymphocytesReceptors, CCR3ImmunohistochemistryCell AdhesionMacrophagesEndothelial CellsReceptors, CCR7Cell LineDisease Models, AnimalReceptors, CCR10Mice, TransgenicReceptors, CCR8Cell ProliferationInterferon-gammaChemokine CCL24CD4-Positive T-LymphocytesReceptors, CytokineMonocyte Chemoattractant ProteinsBlotting, WesternGene ExpressionProtein BindingReceptors, CCRBone Marrow CellsGene Expression ProfilingChemokines, CX3CChemotactic FactorsReceptors, CCR6Cell DifferentiationTransfectionTime FactorsMonokinesMonocytesNeutrophilsLigandsReceptors, HIVDuffy Blood-Group SystemDendritic CellsCell Migration InhibitionIntercellular Signaling Peptides and Proteins
Chemokine CXCL12
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
Chemokine CXCL13
A CXC chemokine that is chemotactic for B-LYMPHOCYTES. It has specificity for CXCR5 RECEPTORS.
Chemokine CXCL10
A CXC chemokine that is induced by GAMMA-INTERFERON and is chemotactic for MONOCYTES and T-LYMPHOCYTES. It has specificity for the CXCR3 RECEPTOR.
Chemokine CXCL6
A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.
Chemokine CXCL11
A CXC chemokine that is induced by GAMMA-INTERFERON. It is a chemotactic factor for activated T-LYMPHOCYTES and has specificity for the CXCR3 RECEPTOR.
Chemokine CXCL1
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
Chemokine CXCL9
An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.
Chemokines, CXC
Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.
Receptors, Chemokine
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Receptors, CXCR
Chemokine receptors that are specific for CXC CHEMOKINES.
Chemokine CXCL5
A CXC chemokine that is predominantly expressed in EPITHELIAL CELLS. It has specificity for the CXCR2 RECEPTORS and is involved in the recruitment and activation of NEUTROPHILS.
Receptors, CXCR4
CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.
Receptors, CXCR3
CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.
Chemokines
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Chemokine CCL5
A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.
Receptors, CXCR5
CXCR receptors isolated initially from BURKITT LYMPHOMA cells. CXCR5 receptors are expressed on mature, recirculating B-LYMPHOCYTES and are specific for CHEMOKINE CXCL13.
Receptors, Interleukin-8B
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.
Chemokine CCL2
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
Chemokine CXCL2
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
Chemokine CCL21
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
Chemotaxis, Leukocyte
The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.
Chemokine CCL4
A CC chemokine with specificity for CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES and a variety of other immune cells. This chemokine is encoded by multiple genes.
Cell Movement
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Chemokine CCL22
A CC-type chemokine with specificity for CCR4 RECEPTORS. It has activity towards TH2 CELLS and TC2 CELLS.
Chemokine CCL3
A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES; and a variety of other immune cells. This chemokine is encoded by multiple genes.
Chemokine CCL17
A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.
Receptors, Scavenger
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
Chemokine CCL19
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.
Chemokine CX3CL1
A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. The membrane form of the protein may also play a role in cell adhesion.
Chemokines, CC
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
Interleukin-8
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Heterocyclic Compounds
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Chemotaxis
The movement of cells or organisms toward or away from a substance in response to its concentration gradient.
Mice, Inbred C57BL
Platelet Factor 4
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Chemokine CCL7
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS.
Chemokine CCL20
A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Chemokine CCL11
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
Chemokine CCL1
A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. It has specificity for CCR8 RECEPTORS.
Neutrophil Infiltration
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Chemokine CCL27
A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Up-Regulation
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Receptors, CCR2
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.
Receptors, CCR1
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Receptors, CCR5
CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.
Chemokine CCL8
A monocyte chemoattractant protein that attracts MONOCYTES; LYMPHOCYTES; BASOPHILS; and EOSINOPHILS. Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Macrophage Inflammatory Proteins
Heparin-binding proteins that exhibit a number of inflammatory and immunoregulatory activities. Originally identified as secretory products of MACROPHAGES, these chemokines are produced by a variety of cell types including NEUTROPHILS; FIBROBLASTS; and EPITHELIAL CELLS. They likely play a significant role in respiratory tract defenses.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Receptors, CCR4
CCR receptors with specificity for CHEMOKINE CCL17 and CHEMOKINE CCL22. They are expressed at high levels in T-LYMPHOCYTES; MAST CELLS; DENDRITIC CELLS; and NK CELLS.
Receptors, Interleukin-8A
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and BASOPHILS.
Mice, Inbred BALB C
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Receptors, CCR3
CCR receptors with specificity for CHEMOKINE CCL11 and a variety of other CC CHEMOKINES. They are expressed at high levels in T-LYMPHOCYTES; EOSINOPHILS; BASOPHILS; and MAST CELLS.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cell Adhesion
Adherence of cells to surfaces or to other cells.
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Receptors, CCR7
CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Receptors, CCR10
CCR receptors with specificity for CHEMOKINE CCL27. They may play a specialized role in the cutaneous homing of LYMPHOCYTES.
Mice, Transgenic
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Receptors, CCR8
CCR receptors with specificity for CHEMOKINE CCL1. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and MACROPHAGES.
Cell Proliferation
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Chemokine CCL24
A CC-type chemokine with specificity for CCR3 RECEPTORS. It is a chemoattractant for EOSINOPHILS.
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Receptors, Cytokine
Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.
Monocyte Chemoattractant Proteins
Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Receptors, CCR
Chemokine receptors that are specific for CC CHEMOKINES.
Bone Marrow Cells
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Gene Expression Profiling
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Chemokines, CX3C
Group of chemokines with the first two cysteines separated by three amino acids. CX3C chemokines are chemotactic for natural killer cells, monocytes, and activated T-cells.
Chemotactic Factors
Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.
Receptors, CCR6
CCR receptors with specificity for CHEMOKINE CCL20. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
Cell Differentiation
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Monokines
Soluble mediators of the immune response that are neither antibodies nor complement. They are produced largely, but not exclusively, by monocytes and macrophages.
Monocytes
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Neutrophils
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Receptors, HIV
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. Included are CD4 ANTIGENS, found on T4 lymphocytes, and monocytes/macrophages, which bind to the HIV ENVELOPE PROTEIN GP120.
Duffy Blood-Group System
A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Cell Migration Inhibition
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Inflammation Mediators
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
NF-kappa B
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Lung
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Chemotactic Factors, Eosinophil
Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.
Leukocytes
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
HIV-1
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Stromal Cells
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Down-Regulation
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Th2 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Lymph Nodes
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Leukocytes, Mononuclear
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Th1 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Angiostatic Proteins
Proteins that specifically inhibit the growth of new blood vessels (ANGIOGENESIS, PHYSIOLOGIC).
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Eosinophils
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Immunity, Innate
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
Lymphoid Tissue
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
T-Lymphocyte Subsets
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
CD8-Positive T-Lymphocytes
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Coculture Techniques
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
Transendothelial and Transepithelial Migration
The passage of cells across the layer of ENDOTHELIAL CELLS, i.e., the ENDOTHELIUM; or across the layer of EPITHELIAL CELLS, i.e. the EPITHELIUM.

The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. (1/169)

Recruitment of activated T cells to mucosal surfaces, such as the airway epithelium, is important in host defense and for the development of inflammatory diseases at these sites. We therefore asked whether the CXC chemokines IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC), which specifically chemoattract activated T cells by signaling through the chemokine receptor CXCR3, were inducible in respiratory epithelial cells. The effects of proinflammatory cytokines, including IFN-gamma (Th1-type cytokine), Th2-type cytokines (IL-4, IL-10, and IL-13), and dexamethasone were studied in normal human bronchial epithelial cells (NHBEC) and in two human respiratory epithelial cell lines, A549 and BEAS-2B. We found that IFN-gamma, but not TNF-alpha or IL-1 beta, strongly induced IP-10, Mig, and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types. High levels of IP-10 protein (> 800 ng/ml) were detected in supernatants of IFN-gamma/TNF-alpha-stimulated NHBEC. Neither dexamethasone nor Th2 cytokines modulated IP-10, Mig, or I-TAC expression. Since IFN-gamma is up-regulated in tuberculosis (TB), using in situ hybridization we studied the expression of IP-10 in the airways of TB patients and found that IP-10 mRNA was expressed in the bronchial epithelium. In addition, IP-10-positive cells obtained by bronchoalveolar lavage were significantly increased in TB patients compared with normal controls. These results show that activated bronchial epithelium is an important source of IP-10, Mig, and I-TAC, which may, in pulmonary diseases such as TB (in which IFN-gamma is highly expressed) play an important role in the recruitment of activated T cells.  (+info)

Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils. (2/169)

Monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein of 10 kDa (IP-10) are related members of the CXC chemokine subfamily that bind to a common receptor, CXCR3, and that are produced by different cell types in response to IFN-gamma. We have recently reported that human polymorphonuclear neutrophils (PMN) have the capacity to release IP-10. Herein, we show that PMN also have the ability to produce MIG and to express I-TAC mRNA in response to IFN-gamma in combination with either TNF-alpha or LPS. While IFN-gamma, alone or in association with agonists such as fMLP, IL-8, granulocyte (G)-CSF and granulocyte-macrophage (GM)-CSF, failed to influence MIG, IP-10, and I-TAC gene expression, IFN-alpha, in combination with TNF-alpha, LPS, or IL-1beta, resulted in a considerable induction of IP-10 release by neutrophils. Furthermore, IL-10 and IL-4 significantly suppressed the expression of MIG, IP-10, and I-TAC mRNA and the extracellular production of MIG and IP-10 in neutrophils stimulated with IFN-gamma plus either LPS or TNF-alpha. Finally, supernatants harvested from stimulated PMN induced migration and rapid integrin-dependent adhesion of CXCR3-expressing lymphocytes; these activities were significantly reduced by neutralizing anti-MIG and anti-IP-10 Abs, suggesting that they were mediated by MIG and IP-10 present in the supernatants. Since MIG, IP-10, and I-TAC are potent chemoattractants for NK cells and Th1 lymphocytes, the ability of neutrophils to produce these chemokines might contribute not only to the progression and evolution of the inflammatory response, but also to the regulation of the immune response.  (+info)

Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (3/169)

Chemokines and their receptors play a crucial part in the recruitment of leukocytes into inflammatory sites. The CXC chemokines IP-10 and Mig are selective attractants for activated (memory) T cells, the predominant cell type in skin infiltrates in many inflammatory dermatoses. The selectivity for activated T cells can be explained by the fact that both chemokines exert their effects through a common receptor, CXCR3, which is nearly exclusively expressed on activated T cells. The aim of this study was to identify biologically active CXCR3 ligands produced by keratinocytes. To that end, Chinese hamster ovary cells expressing a cDNA encoding CXCR3 were challenged with proteins obtained from interferon-gamma stimulated keratinocytes and subsequently monitored for effects on second messenger systems. By this approach we were able to isolate IP-10 and Mig, and in addition identified a novel highly potent ligand for the CXCR3 receptor, designated interferon-gamma-inducible protein-9, which proved to be chemotactic for activated T cells expressing CXCR3. Protein sequence and mass spectrometric analysis followed by molecular cloning of the cDNA encoding interferon-gamma-inducible protein-9, revealed that interferon-gamma-inducible protein-9 is a CXC chemokine with a molecular mass of 8303 Da. From a GenBank database query it became clear that interferon-gamma-inducible protein-9 is in fact the protein encoded by the cDNA sequence also known as beta-R1, H174 or I-TAC. In situ hybridization experiments showed that interferon-gamma-inducible protein-9 mRNA is expressed by basal layer keratinocytes in a variety of skin disorders, including allergic contact dermatitis, lichen planus, and mycosis fungoides suggesting a functional role for this chemokine in skin immune responses.  (+info)

Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. (4/169)

CXCL 11, encoded by the cDNA sequences designated beta-R1, H-174, or I-TAC, is a CXC chemokine ligand for CXCR3 and assumed to be involved in inflammatory diseases characterized by the presence of activated T-cells. We here describe the genomic organization (four exons interrupted by three introns of 585, 98 and 230 bp) and sequence including 960 bp from the immediate 5'-upstream region of the human CXCL 11 gene. Within the promoter region, consensus sequences for regulatory elements (ISRE, GAS, NF-kappaB) important for cytokine-induced gene transcription were identified. The effect of (pro)inflammatory cytokines on CXCL 11 mRNA expression in monocytic cell lines (THP-1, U937) and primary cultures of dermal fibroblasts and endothelial cells were examined using Northern blot analysis. For these cell types, IFN-gamma was a potent inducer of CXCL 11 transcription, which was synergistically enhanced by TNF-alpha.  (+info)

The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions. (5/169)

Differentiation between allergic and irritant contact dermatitis reactions is difficult, as both inflammatory diseases are clinically, histologically, and immunohistologically very similar. Previous studies in mice revealed that the chemokine IP-10 is exclusively expressed in allergic contact dermatitis reactions. In the present study, we investigated whether the mRNA expression of IP-10 and the related CXCR3 activating chemokines, Mig and IP-9 are also differentially expressed in human allergic contact dermatitis and irritant contact dermatitis reactions. Skin biopsies from allergic (13 cases) and sodium lauryl sulfate-induced irritant patch test reactions (13 cases), obtained 1-72 h after patch testing, were studied by means of an in situ hybridization technique. Results of chemokine mRNA expression were correlated with clinical scoring, histology, and immunohistochemical data including the proportion of inflammatory cells expressing CXCR3, the receptor for IP-10, Mig, and IP-9, and ICAM-1 and HLA-DR expression on keratinocytes. IP-10, Mig, and IP-9 mRNA were detected in seven of nine allergic contact dermatitis reactions after 24-72 h, but not in sodium lauryl sulfate-induced irritant contact dermatitis reactions. ICAM-1 expression by keratinocytes was only found in allergic contact dermatitis reactions and correlated with chemokine expression. Moreover, up to 50% of the infiltrating cells in allergic contact dermatitis expressed CXCR3, in contrast to only 20% in irritant contact dermatitis reactions. In conclusion, we have demonstrated differences in chemokine expression between allergic contact dermatitis and irritant contact dermatitis reactions, which might reflect different regulatory mechanisms operating in these diseases and may be an important clue for differentiation between allergic contact dermatitis and irritant contact dermatitis reactions.  (+info)

Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells. (6/169)

Activated T lymphocytes accumulate early in atheroma formation and persist at sites of lesion growth and rupture, suggesting that they may play an important role in the pathogenesis of atherosclerosis. Moreover, atherosclerotic lesions contain the Th1-type cytokine IFN-gamma, a potentiator of atherosclerosis. The present study demonstrates the differential expression of the 3 IFN-gamma-inducible CXC chemokines--IFN-inducible protein 10 (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha chemoattractant (I-TAC)--by atheroma-associated cells, as well as the expression of their receptor, CXCR3, by all T lymphocytes within human atherosclerotic lesions in situ. Atheroma-associated endothelial cells (ECs), smooth muscle cells (SMCs), and macrophages (MO) all expressed IP-10, whereas Mig and I-TAC were mainly expressed in ECs and MO, as detected by double immunofluorescence staining. ECs of microvessels within lesions also expressed abundant I-TAC. In vitro experiments supported these results and showed that IL-1beta, TNF-alpha, and CD40 ligand potentiated IP-10 expression from IFN-gamma-stimulated ECs. In addition, nitric oxide (NO) treatment decreased IFN-gamma induction of IP-10. Our findings suggest that the differential expression of IP-10, Mig, and I-TAC by atheroma-associated cells plays a role in the recruitment and retention of activated T lymphocytes observed within vascular wall lesions during atherogenesis.  (+info)

Expression of IFN-inducible T cell alpha chemoattractant by human endothelial cells is cyclosporin A-resistant and promotes T cell adhesion: implications for cyclosporin A-resistant immune inflammation. (7/169)

IFN-inducible T cell alpha chemoattractant (I-TAC) is a recently discovered member of the CXC chemokine family. It is a potent T cell chemoattractant expressed by IFN-gamma-treated astrocytes, monocytes, keratinocytes, bronchial epithelial cells, and neutrophils. In this study, we show that I-TAC is also expressed by IFN-gamma-treated endothelial cells (EC), both at the mRNA and protein levels. Induction of the I-TAC message is rapid and sustained over 24 h. TNF-alpha does not induce I-TAC mRNA alone, but does act synergistically with IFN-gamma. Blocking Abs to I-TAC, or to its receptor, CXCR3, reduce T cell adhesion to EC monolayers demonstrating that the expressed protein is functional. Finally, the expression of I-TAC by EC is resistant to the immunosuppressive drug cyclosporin A, suggesting that I-TAC may contribute to the chronic immune inflammation characteristic of graft arteriosclerosis.  (+info)

The murine chemokine CXCL11 (IFN-inducible T cell alpha chemoattractant) is an IFN-gamma- and lipopolysaccharide-inducible glucocorticoid-attenuated response gene expressed in lung and other tissues during endotoxemia. (8/169)

A new murine chemokine was identified in a search for glucocorticoid-attenuated response genes induced in the lung during endotoxemia. The first 73 residues of the predicted mature peptide are 71% identical and 93% similar to human CXCL11/IFN-inducible T cell alpha chemoattractant (I-TAC) (alias beta-R1, H174, IFN-inducible protein 9 (IP-9), and SCYB9B). The murine chemokine has six additional residues at the carboxyl terminus not present in human I-TAC. Identification of this cDNA as murine CXCL11/I-TAC is supported by phylogenetic analysis and by radiation hybrid mapping of murine I-TAC (gene symbol Scyb11) to mouse chromosome 5 close to the genes for monokine induced by IFN-gamma (MIG) and IP10. Murine I-TAC mRNA is induced in RAW 264.7 macrophages by IFN-gamma or LPS and is weakly induced by IFN-alphabeta. IFN-gamma induction of murine I-TAC is markedly enhanced by costimulation with LPS or IL-1beta in RAW cells and by TNF-alpha in both RAW cells and Swiss 3T3 fibroblasts. Murine I-TAC is induced in multiple tissues during endoxemia, with strongest expression in lung, heart, small intestine, and kidney, a pattern of tissue expression different from those of MIG and IP10. Peak expression of I-TAC message is delayed compared with IP10, both in lung after i.v. LPS and in RAW 264.7 cells treated with LPS or with IFN-gamma. Pretreatment with dexamethasone strongly attenuates both IFN-gamma-induced I-TAC expression in RAW cells and endotoxemia-induced I-TAC expression in lung and small intestine. The structural and regulatory similarities of murine and human I-TAC suggest that mouse models will be useful for investigating the role of this chemokine in human biology and disease.  (+info)

Interferon-Inducible T Cell α-Chemoattractant (human) H-4606 | BachemInterferon-Inducible T Cell α-Chemoattractant (human) H-4606 | Bachem
Bachem offers H-4606 Interferon-Inducible T Cell α-Chemoattractant (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
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CXCL11 - WikipediaCXCL11 - Wikipedia
C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.[3] C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[4] Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[5] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[4][6] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[7][8] ...
https://en.wikipedia.org/wiki/CXCL11
iTac2 Extra Strength 20giTac2 Extra Strength 20g
iTac2 Pole Dance Grip works by adding the perfect level of moisture and stick to the skin providing a strong, reliable gripping surface for your hands and/or body - helping you to improve control while conserving energy and repelling sweat and moisture. iTac2 is suitable for use on many types of poles.We recommend Regu
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The proinflammatory CXC-chemokines GRO-α/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease...The proinflammatory CXC-chemokines GRO-α/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease...
Background Ulcerative colitis is characterized by relapsing mucosal inflammation where the lesions include tissue-damaging granulocytes. In addition, T cells and natural killer (NK) cells play important pathophysiologic roles. Chemokines are a large family of peptides that play key roles in the regulation of inflammation. The CXC-chemokines, growth-related oncogene (GRO)-α/CXCL1 and interleukin (IL)-8/CXCL8, both recruit neutrophils and possess mitogenic properties, whereas the interferon-dependent CXC-chemokines monokine induced by gamma-interferon (MIG)/CXCL9, interferon-γ inducible protein of 10 kD/CXCL10, and IFN-inducible T cell alpha chemoattractant/CXCL11 recruit and activate T cells and NK cells. Materials and methods The expression of CXC-chemokines was studied in eight controls and in 11 patients suffering from ulcerative colitis in the distal part of the colon, before and during topical treatment with corticosteroids. Perfusates (obtained before, after 7 days, and after 28 days of ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:45287
Most recent papers with the keyword Skin genomics | Read by QxMDMost recent papers with the keyword Skin genomics | Read by QxMD
Lemongrass ( Cymbopogon flexuosus ) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF ...
https://www.readbyqxmd.com/keyword/58952
Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C<...Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C<...
TY - JOUR. T1 - Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C. AU - Zeremski, Marija. AU - Petrovic, Lydia M.. AU - Chiriboga, Luis. AU - Brown, Queenie B.. AU - Yee, Herman T.. AU - Kinkhabwala, Milan. AU - Jacobson, Ira M.. AU - Dimova, Rositsa. AU - Markatou, Marianthi. AU - Talal, Andrew H.. PY - 2008/11/1. Y1 - 2008/11/1. N2 - Chemokines, chemotactic cytokines, may promote hepatic inflammation in chronic hepatitis C virus (HCV) infection through the recruitment of lymphocytes to the liver parenchyma. We evaluated the association between inflammation and fibrosis and CXCR3-associated chemokines, interferon-γ (IFN-γ)-inducible protein 10 (IP-10/CXCL10), monokine induced by IFN-γ(Mig/CXCL9), and interferon-inducible T cell α chemoattractant (I-TAC/CXCL11), in HCV infection. Intrahepatic mRNA expression of these chemokines was analyzed in 106 chronic HCV-infected patients by real-time PCR. The intrahepatic ...
https://einstein.pure.elsevier.com/en/publications/intrahepatic-levels-of-cxcr3-associated-chemokines-correlate-with-2
Recombinant Human CXCL11/I-TAC | Cell SciencesRecombinant Human CXCL11/I-TAC | Cell Sciences
|p|Recombinant Human I-TAC is a single non-glycosylated polypeptide chain containing 73 amino acids.|/p| |p|Background: I-TAC/CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence, which is cleav
http://www.cellsciences.com/recombinant-human-cxcl11-i-tac-1
Environmental Industry Software Solutions for iTAC.MES.Suite for Automotive Suppliers applications | Environmental XPRTEnvironmental Industry Software Solutions for iTAC.MES.Suite for Automotive Suppliers applications | Environmental XPRT
Results for environmental industry software with itac.mes.suite for automotive suppliers applications from iTAC.MES and other leading brands. Compare and contact a supplier near you
https://www.environmental-expert.com/software/application-itacmessuite-for-automotive-suppliers
PDB-5n5n: Cryo-EM structure of tsA201 cell alpha1B and betaI and betaIVb mi... - YorodumiPDB-5n5n: Cryo-EM structure of tsA201 cell alpha1B and betaI and betaIVb mi... - Yorodumi
Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images ...
https://pdbj.org/emnavi/quick.php?id=pdb-5n5n
Human CXCL10 IP-10 ELISA MAX DeluxeHuman CXCL10 IP-10 ELISA MAX Deluxe
Human CXCL10 (IP-10) ELISA MAX™ Deluxe - CXCL10, also known as IP-10, is a glutamic acid-leucine-arginine motif negative chemokine structurally and functionally related to MIG (CXCL9) and ITAC (CXCL11).
https://www.biolegend.com/en-us/search-results/human-cxcl10-ip-10-elisa-max-deluxe-8562
Telus takes home corporate IT Hero award | IT World Canada NewsTelus takes home corporate IT Hero award | IT World Canada News
Telus Corp.s use of Upopolis, a social networking tool designed specifically for hospitalized children, has earned the telecommunications giant a corporate IT hero award from the Information Technology Association of Canada (ITAC). Sponsored in part by IT World Canada, the annual ITAC IT Hero Awards celebrates one corporate and one community-based IT achievement that significantly […]
https://www.itworldcanada.com/article/telus-takes-home-corporate-it-hero-award/3456
重组小鼠MIG蛋白(ab50083)|Abcam中国重组小鼠MIG蛋白(ab50083)|Abcam中国
购买我们的重组小鼠MIG蛋白。Ab50083为有活性的全长蛋白，在大肠杆菌中生产并经过SDS-PAGE, Functional Studies实验验证。中国80%以上现货。
http://www.abcam.cn/recombinant-mouse-mig-protein-ab50083.html
Flux Core Vs MIG Welding - WeldingGurusFlux Core Vs MIG Welding - WeldingGurus
MIG welding is another popular Arc welding process. The comparison above has shown us its various pros and cons. This welding process is faster and simpler
https://www.weldinggurus.com/flux-core-vs-mig-welding/
Trust.com - IP-камера с WiFiTrust.com - IP-камера с WiFi
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A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development | JEMA novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development | JEM
This study provides extensive characterization of the novel high affinity SDF-1 (CXCL12)-binding receptor that we reported in an earlier publication (14). The novel receptor, initially designated CCX CKR2 (14) but renamed CXCR7 in this paper, is a 7-transmembrane receptor encoded by RDC1 (21, 22), a gene that, before our initial report (14), belonged to the family of orphan receptors with unknown ligands (20). In addition to binding SDF-1, CXCR7 is also a high affinity receptor for I-TAC (CXCL11) that, before our investigations, was regarded as a ligand for CXCR3 only. Our data show that CXCR7 regulates several important biological processes including cell survival, cell adhesion, and tumor development in animal models. CXCR7 is expressed on many tumor cells but not on most nontransformed cells. Although not expressed on unstimulated endothelial cells, CXCR7 can be induced, in vitro, on cells that form the neovasculature, a finding that is consistent with the independent studies of Madden et ...
http://jem.rupress.org/content/203/9/2201
Weighed against tumor cells, the LP EpCAM+ cells indicated very high degrees of the chemokines CXCL3 and CXCL5, as well as the...Weighed against tumor cells, the LP EpCAM+ cells indicated very high degrees of the chemokines CXCL3 and CXCL5, as well as the...
Weighed against tumor cells, the LP EpCAM+ cells indicated very high degrees of the chemokines CXCL3 and CXCL5, as well as the BAL fluid included raised CXCL1, CXCL2, CXCL5, and CXCL7. have already been utilized and described to build up approaches for targeted treatments, the genomic surroundings of lung SCC is emerging now. There arent yet any authorized targeted therapies for lung SCC. Sadly, therapeutic focuses on in lung ADC, such as for example and (also called serine-threonine kinase 11 [mutations have become rarely within human being squamous lung tumors. Lately, it had been reported that kinase-dead was within reduction is probable a significant determinant of lung squamous tumorigenesis. Despite signs that reduction may be central towards the era of squamous cell malignancies, deletion of only struggles to travel tumor development (Ji et al., 2007). (phosphatase and tensin homolog) can be another frequently mutated, erased, or epigenetically silenced tumor suppressor in human being ...
http://healthychoicess.net/%EF%BB%BFweighed-against-tumor-cells-the-lp-epcam-cells-indicated-very-high-degrees-of-the-chemokines-cxcl3-and-cxcl5-as-well-as-the-bal-fluid-included-raised-cxcl1-cxcl2-cxcl5-and-cxcl7/
Regulation of Paneth cell alpha defensin genes by microbial stimuli - Immunology
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.immunology.ox.ac.uk/publications/66778
Identification des résidus essentiels à linteraction du récepteur CXCR7 avec ses ligands SDF-1 et ITACIdentification des résidus essentiels à linteraction du récepteur CXCR7 avec ses ligands SDF-1 et ITAC
Les chimiokines sont des petites protéines secrétées dont la fonction principale est la stimulation de la migration de cellules immunitaires vers différents organes et tissus. Elles sont souvent impliquées lors des maladies inflammatoires, auto-immunes et des cancers. Ainsi, les chimiokines et leurs récepteurs couplés aux protéines G (RCPG) sont la cible pharmacologique de plusieurs molécules, actuellement testées en essais cliniques. Nous avons pris comme modèle, lors de notre étude, le récepteur atypique CXCR7. Ce récepteur est dit atypique, car il ne signalise pas via la voie classique des protéines G, mais plutôt via la voie de la β-arrestine. CXCR7 est impliqué dans de nombreux cancers, favorise la progression métastatique et est un co-récepteur pour le virus de limmunodéficience humaine (VIH). Cependant, aucune donnée sur son mode de liaison avec ses ligands CXCL11/ITAC et CXCL12/SDF-1 nexiste à date. Nous pensons que cette information est essentielle pour le ...
https://papyrus.bib.umontreal.ca/xmlui/handle/1866/13662
CXCL9/MIG (human), lyophilized (AlphaLISA) | PerkinElmerCXCL9/MIG (human), lyophilized (AlphaLISA) | PerkinElmer
Human C-X-C Motif Chemokine 9 / Monokine Induced by Gamma Interferon (CXCL9 / MIG) standard, for use in running standard curves in AlphaLISA no-wash detection assay
http://www.perkinelmer.com/product/alphalisa-human-cxcl9-mig-lyo-0-3ug-al280s
IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis | The...IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis | The...
IP-10 has been detected in the CSF and brain parenchyma of patients with a variety of neuroinflammatory diseases (15, 26, 43, 44) and is a potent chemoattractant for activated T lymphocytes and NK cells (11). In EAE, an animal model for MS, IP-10 levels in the CNS have been correlated with the development of clinical disease and the recruitment of CXCR3-expressing pathogenic T cells (19, 20, 45). Treatment of SJL mice with Abs to IP-10 before adoptive transfer of encephalitogenic T cells or immunizing mice with naked IP-10 DNA decreased the severity of EAE (29). Based on these observations, IP-10 is thought to be essential for the development of CNS mononuclear infiltrates, and its receptor CXCR3, is considered a putative therapeutic target for diseases involving the trafficking of inflammatory T cells. However, the absolute requirement for IP-10 in EAE has never been directly examined.. In this study, we sought to determine whether IP-10 is required for the development of EAE by analyzing ...
http://www.jimmunol.org/content/172/1/550.long
Recombinant Human CXCR2 HEK293T cell lysate CXCR2-22HCL - Creative BioMart
Purified Recombinant Human CXCR2 HEK293T cell lysate from Creative Biomart. Recombinant Human CXCR2 HEK293T cell lysate can be used for research.
https://www.creativebiomart.net/recombinant-human-cxcr2-hek293t-cell-lysate-467149.htm
LEGEND MAX Human CXCL10 IP-10 ELISA Kit with Pre-coated PlatesLEGEND MAX Human CXCL10 IP-10 ELISA Kit with Pre-coated Plates
LEGEND MAX™ Human CXCL10 (IP-10) ELISA Kit with Pre-coated Plates - CXCL10, also known as IP-10, is a glutamic acid-leucine-arginine motif negative chemokine structurally and functionally related to MIG (CXCL9) and ITAC (CXCL11).
https://www.biolegend.com/de-at/products/legend-max-human-cxcl10-ip-10-elisa-kit-with-pre-coated-plates-8479
Worlds First Hydrogen Bike Gets Fifty Percent Range Boost - Bike EuropeWorlds First Hydrogen Bike Gets Fifty Percent Range Boost - Bike Europe
SHEFFIELD, UK - European hydrogen fuel cell specialists, Pragma Industries, has successfully increased the maximum range of its pioneering hydrogen fuel cell Alpha bike by fifty percent. This could be accomplished by using an advanced, high-pressure gas cylinder from AMS Composite Cylinders.
https://www.bike-eu.com/sales-trends/nieuws/2019/08/worlds-first-hydrogen-bike-gets-fifty-percent-range-boost-10136421
CXCL9 Bovine Protein | MIG Recombinant Chemokine | ProSpecCXCL9 Bovine Protein | MIG Recombinant Chemokine | ProSpec
MIG (CXCL9) Bovine Recombinant is a non-glycosylated polypeptide chain containing 104 amino acids and having a molecular mass of about 18.0kDa.
https://www.prospecbio.com/cxcl9_bovine
Recombinant Human CXCL9 protein CXCL9-17H - Creative BioMart
Recombinant Human MIG/CXCL9 produced in E. coli is a single, non-glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.7 kDa.
https://www.creativebiomart.net/description_3495_12.htm
Aortic and plasma expression levels of IL-18 and CXCL16 | Open-iAortic and plasma expression levels of IL-18 and CXCL16 | Open-i
Aortic and plasma expression levels of IL-18 and CXCL16.(A) Reduced aortic mRNA expression of IL-18 and CXCL16, but no change in the expression of IFN-γ is obs
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2962638_pone.0013539.g007&req=4
IJMS | Free Full-Text | Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan...IJMS | Free Full-Text | Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan...
Chemokines mediate diverse fundamental biological processes, including combating infection. Multiple chemokines are expressed at the site of infection; thus chemokine synergy by heterodimer formation may play a role in determining function. Chemokine function involves interactions with G-protein-coupled receptors and sulfated glycosaminoglycans (GAG). However, very little is known regarding heterodimer structural features and receptor and GAG interactions. Solution nuclear magnetic resonance (NMR) and molecular dynamics characterization of platelet-derived chemokine CXCL7 heterodimerization with chemokines CXCL1, CXCL4, and CXCL8 indicated that packing interactions promote CXCL7-CXCL1 and CXCL7-CXCL4 heterodimers, and electrostatic repulsive interactions disfavor the CXCL7-CXCL8 heterodimer. As characterizing the native heterodimer is challenging due to interference from monomers and homodimers, we engineered a
http://www.mdpi.com/1422-0067/18/4/748
Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC...Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC...
Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000 Jun 15; 164(12):6503-8 ...
https://connects.catalyst.harvard.edu/Profiles/display/749761
A study to evaluate whether the serum interferon-gamma-inducible protein-10 concentrations and IL28B genotype associated with...A study to evaluate whether the serum interferon-gamma-inducible protein-10 concentrations and IL28B genotype associated with...
This study examined the association of interferon-gamma-inducible protein-10 concentrations in serum and IL28B genotype associated with responses to pegylated
http://adisinsight.springer.com/trials/700265990?error=cookies_not_supported&code=1a93b255-ff85-4229-b99d-ff595699ea88
CXCL12 - Википедија, слободна енциклопедијаCXCL12 - Википедија, слободна енциклопедија
CXCL12 izaziva potentnu hemotaksu limfocita.[4][5][6][7] Tokom embriogeneze on usmerava migraciju hematopoetskih ćelija i formiranje velikih krvnih sudova. Miševi bez CXCL12 gena su letalni pre rođenja, ili u toku prvog sata života. Kod odraslih CXCL12 igra važnu ulogu u angiogenezi putem regrutovanja endotelnih progenitorskih ćelija (EPC) iz koštane srži kroz CXCR4 zavistan mehanizam.[8] Ova funkcija čini CXCL12 veoma važnim faktorom u karcinogenezi i neovaskularizaciji vezanoj za progresiju tumora.[9] CXCL12 takođe ima ulogu u metastazi tumora gde su ćelije raka koje izražavaju CXCR4 receptor privučene ka metastaznim ciljnim tkivima koja oslobađaju ligand, CXCL12.[10] Kod raka dojke, međutim, povećano CXCL12 izražavanje određuje umanjeni rizik od metastaze.[11][12] ...
https://sr.wikipedia.org/wiki/CXCL12
For all those datasets cell doublets were excluded (i | kinase inhibitor tool compounds for pharmacological validationFor all those datasets cell doublets were excluded (i | kinase inhibitor tool compounds for pharmacological validation
For all those datasets cell doublets were excluded (i.e., cells which were designated to confirmed cell alpha or typebeta cell, yet express an assortment of cell type-specific markerssuch as both Glucagon and Insulin) (Fig S1, S2, S11). cells, two sub-populations of cells had been determined which diverged in mtDNA gene manifestation, however these mobile populations didnt diverge in nDNA OXPHOS genes manifestation regularly, nor do they correlate using the manifestation of glucagon, the sign of alpha cells. Therefore, pancreatic beta cells in a specific are split into specific groups with original metabolic-mitochondrial personal. with parameter (BWA-backtrack algorithm)57; this allowed following analysis for many mtDNA encoded-genes. Manifestation degrees of all genes had been counted using HTSeq-count v0.11.258, using default guidelines and employing the [-f bam] guidelines. For quality control filtering, gene count number values as described by HTSeq-count had been concatenated right into a ...
https://cdkkinase.com/%EF%BB%BFfor-all-those-datasets-cell-doublets-were-excluded-i/
Human CXCR2/Gi/Go Stable Cell Line-CHO - Creative BiogeneHuman CXCR2/Gi/Go Stable Cell Line-CHO - Creative Biogene
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affin
https://www.creative-biogene.com/Human-CXCR2-Gi-Go-Stable-Cell-Line-CHO-CSC-RG0498-195396-11.html
Human CXCR2 Validated Stable Cell Line-CHO - Creative BiogeneHuman CXCR2 Validated Stable Cell Line-CHO - Creative Biogene
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affin
https://www.creative-biogene.com/Human-CXCR2-Validated-Stable-Cell-Line-CHO-CSC-RG1145-195888-11.html
Recombinant human CXCL5 protein (ab50039) ReferencesRecombinant human CXCL5 protein (ab50039) References
References for Abcams Recombinant human CXCL5 protein (ab50039). Please let us know if you have used this product in your publication
http://www.abcam.com/recombinant-human-cxcl5-protein-ab50039-references.html
ESAB Aristo MIG 5000i Page 1 of 0 | For High Alloyed Materials - CigweldESAB Aristo MIG 5000i Page 1 of 0 | For High Alloyed Materials - Cigweld
The ESAB Aristo Mig 5000i is the ideal partner for when it comes to prefabrication of high alloyed materials with a high demand for the welding performance.
https://www.cigweld.com.au/product/aristo-mig-u5000i/
Plus itPlus it
p53 protein levels increase in HDFs, such as IMR90 and MRC5, during replicative senescence (8-11). Moreover, p53 sequence-specific DNA-binding activity and transcriptional activity also increase during replicative senescence (9, 12). These studies (8-12) have suggested a role for p53 in the onset and maintenance of cellular senescence. Consistent with this idea, the p53-mediated induction of p21 and Gadd45 genes in normal human cells is known (13, 16, 17) to play a role in cell growth arrest. However, the number of p53 target genes whose expression is induced during cellular senescence in HDFs remains rather limited. Therefore, our observations that p53 activates the transcription of IFI16, a candidate cellular senescence gene, in response to certain DNA damage signals in normal human fibroblasts are important.. The IFI16 protein is an IFN-inducible protein and treatment of a variety of cells with IFNs (α, β, or γ) has been shown to result in up-regulation of the IFI16 mRNA and protein (21). ...
http://mcr.aacrjournals.org/content/6/11/1732
GPR-9-6 is a chemokine receptor for TECK. (A) GPR-9-6 t | Open-iGPR-9-6 is a chemokine receptor for TECK. (A) GPR-9-6 t | Open-i
GPR-9-6 is a chemokine receptor for TECK. (A) GPR-9-6 transfectants were examined for chemotactic responses to various concentrations of TECK and I-TAC ranging
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195678_JEM990293.f8&req=4
Recombinant Murine CXCL16Recombinant Murine CXCL16
CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets
https://www.peprotech.com/en/recombinant-murine-cxcl16
人生长调节致癌基因γ(GRO-γ/CXCL3) (Human) 购买/价格/报价/多少钱 | 赛业生物科技有限公司人生长调节致癌基因γ(GRO-γ/CXCL3) (Human) 购买/价格/报价/多少钱 | 赛业生物科技有限公司
人生长调节致癌基因γ(GRO-γ/CXCL3) (Human)首选赛业生物，380余种细胞因子囊括生长调节致癌基因、生长因子、干扰素、白细胞介素、肿瘤坏死因子等所有细胞因子家族，种属齐包括人、鼠、恒河猴及其他种属。赛业提供的生长调节致癌基因品质优良：高活性、高纯度、高稳定性、无热源、无外源因子污染。
https://www.cyagen.com/cn/zh-cn/product/GRO-v-Human.html
Assay Solution. Human CXCL9/MIG ELISA KitAssay Solution. Human CXCL9/MIG ELISA Kit
Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3. Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions. Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region ...
https://assaysolution.com/human-cxcl9mig-elisa-kit
Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction...Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction...
Recent work identified the murine gene homologous to the human T cell attracting chemokine CXC receptor ligand 11 (CXCL11, also termed I-TAC, SCYB11, ss-R1, H174, IP-9). Here, the biological activity and expression patterns of murine CXCL11 relative to CXCL9 (MIG) and CXCL10 (IP-10/crg-2), the other …
https://pubmed.ncbi.nlm.nih.gov/11500837/?dopt=Abstract
CXCL16 - WikipediaCXCL16 - Wikipedia
CXCL16, hemokin (C-X-C motiv) ligand 16, je mali citokin iz CXC hemokin familije. On je veći od drugih hemokina (sadrži 254 aminokiselina). CXCL16 se sastoji od CXC hemokin domaina, mucinu-slične stabljike, transmembranskog domaina i citoplazmatičnog repa koji sadrži potentno mesto tirozin fosforilacije koje može da veže SH2.[1] Ovo su neuobičajene osobine za hemokin, i omobućavaju CXCL16 da bude izražen kao molekul na ćelijskoj površini, kao i rastvorni hemokin.[2] CXCL16 proizvode dendritiske ćelije koje se mogu naći u T ćelijskim zonama limfoidnih organa, i ćelije iz crvene pulpe slezine.[1] Među ćelijama koje se vezuju i migriraju u responsu na CXCL16 su nekoliko podgrupa T ćelija, i NKT ćelije.[1] CXCL16 interaguje sa hemokin receptorom CXCR6, takođe poznatim kao Bonzo.[3][1] Ekspresiju CXCL16 indukuju inflamatorni citokini IFN-gama i TNF-alfa.[2] Gen za ljudski CXCL16 je lociran na hromozomu 17.[1][4] ...
https://sh.wikipedia.org/wiki/CXCL16
CXCL12 - WikipediaCXCL12 - Wikipedia
CXCL12 izaziva potentnu hemotaksu limfocita.[4][5][6][7] Tokom embriogeneze on usmerava migraciju hematopoetskih ćelija i formiranje velikih krvnih sudova. Miševi bez CXCL12 gena su letalni pre rođenja, ili u toku prvog sata života. Kod odraslih CXCL12 igra važnu ulogu u angiogenezi putem regrutovanja endotelnih progenitorskih ćelija (EPC) iz koštane srži kroz CXCR4 zavistan mehanizam.[8] Ova funkcija čini CXCL12 veoma važnim faktorom u karcinogenezi i neovaskularizaciji vezanoj za progresiju tumora.[9] CXCL12 takođe ima ulogu u metastazi tumora gde su ćelije raka koje izražavaju CXCR4 receptor privučene ka metastaznim ciljnim tkivima koja oslobađaju ligand, CXCL12.[10] Kod raka dojke, međutim, povećano CXCL12 izražavanje određuje umanjeni rizik od metastaze.[11][12] ...
https://sh.wikipedia.org/wiki/CXCL12
The Courier News from Blytheville, Arkansas on July 20, 1950 · Page 7The Courier News from Blytheville, Arkansas on July 20, 1950 · Page 7
Thursday, July 20, 1950 ER War Could Hurt Arkansas Balance of Agri-Industry Note: Thi. k itac I»s( X * Kritc of ftorta discussing Arkansu economic, induclrul and business raini) BT RAKI.KV PCKSHING KOCK, July 20. (AP) - Where would Arkansa. Edition of The Courier News
https://www.newspapers.com/newspage/30072/
SufA of the opportunistic pathogen finegoldia magna modulates actions of the antibacterial chemokine MIG/CXCL9, promoting...SufA of the opportunistic pathogen finegoldia magna modulates actions of the antibacterial chemokine MIG/CXCL9, promoting...
The anaerobic bacterium Finegoldia magna is part of the human commensal microbiota, but is also an important opportunistic pathogen. This bacterium expresses a subtilisin-like serine proteinase, SufA, which partially degrade the antibacterial chemokine MIG/CXCL9. Here, we show that MIG/CXCL9 is produced by human keratinocytes in response to inflammatory stimuli. In contrast to the virulent human pathogen Streptococcus pyogenes, the presence of F. magna had no enhancing effect on the MIG/CXCL9 expression by keratinocytes, suggesting poor detection of the latter by pathogen-recognition receptors. When MIG/CXCL9 was exposed to SufA-expressing F. magna, the molecule was processed into several smaller fragments. Analysis by mass spectrometry showed that SufA cleaves MIG/CXCL9 at several sites in the COOH-terminal region of the molecule. At equimolar concentrations, SufA-generated MIG/CXCL9 fragments were not bactericidal against F. magna, but retained their ability to kill S. pyogenes. Moreover, the ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:288971
CXCL10 - Википедија, слободна енциклопедијаCXCL10 - Википедија, слободна енциклопедија
CXCL10, hemokin (C-X-C motiv) ligand 10, ili IP-10[1] je mali citokin iz CXC hemokin familije koji je takođe poznat kao 10 kDa interferon-gama-inducirani protein (γ-IP10 ili IP-10). CXCL10 luči nekoliko ćelijski tipova u responsu na IFN-γ. U te ćelijske tipove spadaju monociti, endotelijalne ćelije i fibroblasti.[2] CXCL10 hemokinu je bilo pripisano nekoliko uloga, kao što su hemoatrakcija monocita/makrofaga, T ćelija, NK ćelija, i dendritskih ćelija, promocija adhezije T ćelija na endotelijalne ćelije, antitumorska aktivnost, i inhibicija formiranja kolonija kičmene moždine i angiogeneze.[3][4] CXCL10 gen je lociran na ljudskom hromozomu 4 u klasteru sa nekoliko drugih CXC hemokina.[5] Ovaj hemokin dejstvuje putem vezivanja na CXCR3 hemokin receptore na ćelijskoj površini.[6]. Tri-dimenzionalna kristalna struktura ovog hemokina je bila utvrđena u 3 različite grupe uslova u rezoluciji do 1.92 A.[7] PDB pristupni kodovi za CXCL10 strukture su: 1lv9, 1o7y, 1o7z i 1o80.[8] ...
https://sr.wikipedia.org/wiki/CXCL10
Permeability - ITAC AdhesivesPermeability - ITAC Adhesives
Waterproofing is the process by which an object is made to resist the ingress of water and is a common requirement in construction coatings and fabric coatings. In construction, waterproofing is required to maintain the building envelope. In addition to this, waterproofing is an integral part of controlling corrosion which requires both water and oxygen to progress. In fabric coating, waterproofing is measured by the head of water (in mm) which can be suspended above the fabric before water seeps through with typical fabric coatings achieving 2,000mm to 3,000mm before allowing water to pass through. This test is more commonly known as the Hydrostatic head test. Fabric coatings can also be used to reduce the rate of absorption of water into the fabric. Waterproofing is particularly important in products such as rainwear, tarpaulins, pond liners, landfill liners, marquees, and tents ...
https://itacadhesives.co.uk/permeability/
OriGene - Cxcl12 (NM 001033883) cDNA CloneOriGene - Cxcl12 (NM 001033883) cDNA Clone
Cxcl12 - Cxcl12 (untagged ORF) - Rat chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) (Cxcl12), transcript variant 3, (10 ug) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Rat_cDNA/RN200482.aspx
Recombinant Human IP-10 / CXCL10 | Cell SciencesRecombinant Human IP-10 / CXCL10 | Cell Sciences
Interferon gamma-induced protein 10 (IP-10), or CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon gamma (IFN-ɣ).
https://www.cellsciences.com/recombinant-human-ip-10-cxcl10-15175
Human IP-10 (CXCL10) | STEMCELL TechnologiesHuman IP-10 (CXCL10) | STEMCELL Technologies
IP-10 (CXCL10) regulates innate and adaptive immunity by regulating T cells, natural killer cells, dendritic cells, macrophages, and B cells.
https://www.stemcell.com/products/product-types/cytokines/human-recombinant-ip-10-cxcl10.html
Chemokine-mediated inflamma... - Researchers - ANUChemokine-mediated inflamma... - Researchers - ANU
Rutar, M, Natoli, R, Chia, R et al 2015, Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium, Journal of Neuroinflammation, vol. 12, no. 8, pp. 1-15. ...
https://researchers.anu.edu.au/publications/103607
CXCL8 | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYCXCL8 | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. CXCL8 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
http://guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=821
CXCL2 | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYCXCL2 | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. CXCL2 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
http://guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=827
CXCL11CXCL11
C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene. C-X-C motif chemokine 11 is a ... Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its ... "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11". Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin ... Human CXCL11 genome location and CXCL11 gene details page in the UCSC Genome Browser. Rani MR, Foster GR, Leung S, Leaman D, ...
https://en.wikipedia.org/wiki/CXCL11
CXCL9CXCL9
It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on ... Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as ... Campbell JD, Stinson MJ, Simons FE, Rector ES, HayGlass KT (July 2001). "In vivo stability of human chemokine and chemokine ... Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH (December 1999). "Chemokine and chemokine receptor interactions ...
https://en.wikipedia.org/wiki/CXCL9
ACKR3ACKR3
It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a ... Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159 ... "Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7". * Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, ... June 2020). "The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides". Nature ...
https://en.wikipedia.org/wiki/ACKR3
CXC chemokine receptorsCXC chemokine receptors
There are two isoforms, CXCR3-A and CXCR3-B. It has three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11. CXCR4 ( ... CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine ... However, CXCR6 is more closely related in structure to CC chemokine receptors than to other CXC chemokine receptors. ACKR3 was ... within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene ...
https://en.wikipedia.org/wiki/CXC_chemokine_receptors
Cell-mediated immunityCell-mediated immunity
The main chemokine receptors on these cells are CXCR3A and CCR5. Epithelial cells and keratinocytes are able to recruit TH1 ... cells to sights of infection by releasing the chemokines CXCL9, CXCL10 and CXCL11 in response to interferon gamma. Additionally ... CCR5 and CXCR3 are the main chemokine receptors for this cell. Group 1 ILCs Groups 1 ILCs are defined to include ILCs ... TH1 cells are also characterized by the expression of chemokine receptors which allow their movement to sites of inflammation. ...
https://en.wikipedia.org/wiki/Cell-mediated_immunity
ImmunoeditingImmunoediting
... as well as promoting the production of chemokines CXCL10, CXCL9 and CXCL11. These chemokines play an important role in ... The recruitment of more immune cells also occurs and is mediated by the chemokines produced during the inflammatory process. In ...
https://en.wikipedia.org/wiki/Immunoediting
ChemokineChemokine
CXCL10 and CXCL11 are secreted. Mast cells: on their surface express several receptors for chemokines: CCR1, CCR2, CCR3, CCR4, ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ...
https://en.wikipedia.org/wiki/Chemokine
CXCR3CXCR3
... -A binds to the CXC chemokines CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) whereas CXCR3-B can also bind to CXCL4 in ... Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G ... Chemokine receptors Chemokine Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000186810 - Ensembl, May 2017 GRCm38 ... "Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients". The ...
https://en.wikipedia.org/wiki/CXCR3
SNX8SNX8
... and secretion proteins of the chemokine family such as CXCL9, CXCL10, and CXCL11 which present direct antimicrobial activity. ...
https://en.wikipedia.org/wiki/SNX8
Index of immunology articlesIndex of immunology articles
Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 CXCL10 CXCL11 ... Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... 7 Calreticulin Cancer immunology Cancer immunoprevention Cancer immunotherapy Cantuzumab ravtansine Cathelicidin CC chemokine ...
https://en.wikipedia.org/wiki/Index_of_immunology_articles
CXCL10CXCL10
C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human ... CXCL9, CXCL10 and CXCL11 have proven to be valid biomarkers for the development of heart failure and left ventricular ... This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal ... Overview of all the structural information available in the PDB for UniProt: P02778 (C-X-C motif chemokine 10) at the PDBe-KB. ...
https://en.wikipedia.org/wiki/CXCL10
Chromosome 4Chromosome 4
... chemokine (C-X-C motif) ligand 9, scyb9 CXCL10: chemokine (C-X-C motif) ligand 10, scyb10 CXCL11: chemokine (C-X-C motif) ... chemokine (C-X-C motif) ligand 1, scyb1 CXCL2: chemokine (C-X-C motif) ligand 2, scyb2 CXCL3: chemokine (C-X-C motif) ligand 3 ... chemokine (C-X-C motif) ligand 5, scyb5 CXCL6: chemokine (C-X-C motif) ligand 6, scyb6 CXCL7: chemokine (C-X-C motif) ligand 7 ... scyb3 CXCL4: chemokine (C-X-C motif) ligand 4, Platelet factor-4, PF-4, scyb4 CXCL5: ...
https://en.wikipedia.org/wiki/Chromosome_4
Epigenetics of autoimmune disordersEpigenetics of autoimmune disorders
Psoriatic arthritis patients secrete high levels of immune-regulated cytokines and chemokines. It has been shown that ... CXCL11, and TNFSF15 which all are related to an immune response helping to identify the pathway in which DLE is manifested ...
https://en.wikipedia.org/wiki/Epigenetics_of_autoimmune_disorders
Murine respirovirusMurine respirovirus
... chemokine (C-C motif) ligand 5, and chemokine (C-X-C motif) ligand 10. These molecules activate both CD8+ T cells as well as ... Among the ten most virus-induced mRNAs are IFNα8, IFNα13, IFNβ, IFNλ: (L28α, IL28β, IL29), OASL, CXCL10, CXCL11 and HERC5. ... chemokine (C-C motif) ligand 5, and chemokine (C-X-C motif) ligand 10. These molecules activate both CD8+ T cells as well as ... Among the ten most virus-induced mRNAs are IFNα8, IFNα13, IFNβ, IFNλ: (L28α, IL28β, IL29), OASL, CXCL10, CXCL11 and HERC5. ...
https://en.wikipedia.org/wiki/Murine_respirovirus
2014 Ju-Jitsu World Championships2014 Ju-Jitsu World Championships
The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...
https://en.wikipedia.org/wiki/2014_Ju-Jitsu_World_Championships
Bolley JohnsonBolley Johnson
Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...
https://en.wikipedia.org/wiki/Bolley_Johnson
Dont Say NoDon't Say No
... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...
https://en.wikipedia.org/wiki/Don't_Say_No
Dewoitine D.371Dewoitine D.371
The Dewoitine 37 was the first of a family of 1930s French-built monoplane fighter aircraft. The D.37 was a single-seat aircraft of conventional configuration. Its fixed landing gear used a tailskid. The open cockpit was located slightly aft of the parasol wing. The radial engine allowed for a comparatively wide fuselage and cockpit. Design of this machine was by SAF-Avions Dewoitine but owing to over work at that companies plant at the time, manufacture of the D.37/01 was transferred to Lioré et Olivier. They were high-wing monoplanes of all-metal construction with valve head blisters on their engine cowlings. The first prototype flew in October 1931. Flight testing resulted in the need for multiple revisions in both engine and airframe, so it was February 1934 before the second prototype flew. Its performance prompted the French government to order for 28 for the Armée de l'Air and Aéronavale. The Lithuanian government ordered 14 that remained in service with their Air Force until 1936, ...
https://en.wikipedia.org/wiki/Dewoitine_D.371
Noor-ul-AinNoor-ul-Ain
The Noor-ul-Ain (Persian: نور العين, lit. 'the light of the eye') is one of the largest pink diamonds in the world, and the centre piece of the tiara of the same name. The diamond is believed to have been recovered from the mines of Golconda, Hyderabad in India. It was first in possession with the nizam Abul Hasan Qutb Shah, later it was given as a peace offering to the Mughal emperor Aurangazeb when he defeated him in a siege. It was brought into the Iranian Imperial collection after the Persian king Nader Shah Afshar looted Delhi in the 18th century.[citation needed] The Noor-ul-Ain is believed to have once formed part of an even larger gem called the Great Table diamond. That larger diamond is thought to have been cut in two, with one section becoming the Noor-ul-Ain and the other the Daria-i-Noor diamond. Both of these pieces are currently part of the Iranian Crown Jewels. The Noor-ul-Ain is the principal diamond mounted in a tiara of the same name made for Iranian Empress Farah ...
https://en.wikipedia.org/wiki/Noor-ul-Ain
Benoist Land Tractor Type XIIBenoist Land Tractor Type XII
The Benoist Land Tractor Type XII was one of the first enclosed cockpit, tractor configuration aircraft built. Benoist used "Model XII" to several aircraft that shared the same basic engine and wing design, but differed in fuselage and control surfaces. The Type XII was a tractor-engined conversion of the model XII headless pusher aircraft that resembled the Curtiss pusher aircraft. Demonstration pilots used Benoist aircraft to demonstrate the first parachute jumps, and the tractor configuration was considered much more suitable for the task. The first example named the "Military Plane" had a small box frame covered fuselage that left the occupants mostly exposed to the wind. The later model XII "Cross Country Plane" had a full fuselage that occupants sat inside of. The first tractor biplane used a wooden fuselage with a small seat on top. The wings were covered with a Goodyear rubberized cloth. The first model XII was built in the spring of 1912. On 1 March 1912, Albert Berry used a headless ...
https://en.wikipedia.org/wiki/Benoist_Land_Tractor_Type_XII
Santa Cruz BarillasSanta Cruz Barillas
... (also known as Yalmotx in Qʼanjobʼal) is a town, with a population of 17,166 (2018 census), and a municipality in the Guatemalan department of Huehuetenango. It is situated at 1450 metres above sea level. It covers a terrain of 1,174 km². The annual festival is April 29-May 4. Barillas has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round and extremely heavy rainfall from June to August. Citypopulation.de Population of departments and municipalities in Guatemala Citypopulation.de Population of cities & towns in Guatemala "Climate: Barillas". Climate-Data.org. Retrieved July 26, 2020. Muni in Spanish Website of Santa Cruz Barillas Coordinates: 15°48′05″N 91°18′45″W / 15.8014°N 91.3125°W / 15.8014; -91.3125 v t e (Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no coordinates, Articles containing Q'anjob'al-language text, Coordinates on Wikidata, ...
https://en.wikipedia.org/wiki/Santa_Cruz_Barillas
Maria Margaret PollenMaria Margaret Pollen
Maria Margaret La Primaudaye Pollen (10 April 1838 - c. 1919), known as Minnie, was a decorative arts collector. As Mrs John Hungerford Pollen, she became known during the early-twentieth century as an authority on the history of textiles, publishing Seven Centuries of Lace in 1908. Maria Margaret La Primaudaye was born into a Huguenot family on 10 April 1838, the third child of the Revd Charles John La Primaudaye, a descendant of Pierre de La Primaudaye. She was educated in Italy. Her family converted to Catholicism in 1851, and it was in Rome that her father met another recent English convert, John Hungerford Pollen, previously an Anglican priest and a decorative artist. She became engaged to Pollen, who was then seventeen years her senior, in the summer of 1854, and was married in the church of Woodchester monastery, near Stroud, Gloucester, on 18 September 1855. The Pollens initially settled in Dublin, where John Hungerford Pollen had been offered the professorship of fine arts at the ...
https://en.wikipedia.org/wiki/Maria_Margaret_Pollen
Ronald FoglemanRonald Fogleman
Ronald Robert Fogleman (born January 27, 1942) is a retired United States Air Force general who served as the 15th Chief of Staff of the Air Force from 1994 to 1997 and as Commanding General of the United States Transportation Command from 1992 to 1994. A 1963 graduate from the United States Air Force Academy, he holds a master's degree in military history and political science from Duke University. A command pilot and a parachutist, he amassed more than 6,800 flying hours in fighter, transport, tanker and rotary wing aircraft. He flew 315 combat missions and logged 806 hours of combat flying in fighter aircraft. Eighty of his missions during the Vietnam War were as a "Misty FAC" in the F-100F Super Sabre at Phù Cát Air Base, South Vietnam between 25 December 1968 and 23 April 1969. Fogleman was shot down in Vietnam in 1968, while piloting an F-100. He was rescued by clinging to an AH-1 Cobra attack helicopter that landed at the crash site. In early assignments he instructed student pilots, ...
https://en.wikipedia.org/wiki/Ronald_Fogleman
Peachtree Street (song)Peachtree Street (song)
Peachtree Street" is a 1950 song co-written and recorded by Frank Sinatra in a duet with Rosemary Clooney. The song was released as a Columbia Records single. Frank Sinatra co-wrote the song with Leni Mason and Jimmy Saunders. Mason composed the music while Sinatra and Saunders wrote the lyrics. The song was arranged by George Siravo The song was released as an A side Columbia 10" 78 single, Catalog Number 38853, Matrix Number CO-43100-1 and as a 7" 33, 1-669. The B side was the re-issued "This Is the Night." Neither of the songs charted. The subject of the song is a stroll down the street in Atlanta, Georgia of the same name. Sinatra originally intended Dinah Shore to sing the duet with him. When Shore declined, Clooney was asked. The song was recorded on April 8, 1950. The song features spoken asides by Sinatra and Clooney. Rosemary Clooney asks: "Say, Frank, you wanna take a walk?" Frank Sinatra replies: "Sure, sweetie, just pick a street." He noted how there were no peach trees on the ...
https://en.wikipedia.org/wiki/Peachtree_Street_(song)
We, Too, Have a Job to DoWe, Too, Have a Job to Do
... is a painting by American illustrator Norman Rockwell that depicts a Boy Scout in full uniform standing in front of a waving American flag. It was originally created by Rockwell in 1942 for the 1944 Brown & Bigelow Boy Scout Calendar. The model, Bob Hamilton, won a contest to be in the painting and personally delivered a print to the Vice President of the United States at the time, Henry A. Wallace. The painting was created to encourage Scouts to participate in the war effort during World War II. The name of the painting, We, Too, Have a Job to Do, comes from a slogan that the Boy Scouts of America used in 1942 to rally scouts to support the troops by collecting metal and planting victory gardens. The model, Bob Hamilton, won a contest with his local council in Albany, New York, to be depicted in the painting. He traveled to Rockwell's studio in Arlington, Vermont, to model for Rockwell. Since Hamilton was a scout, the uniform shown in the painting was his, unlike some ...
https://en.wikipedia.org/wiki/We,_Too,_Have_a_Job_to_Do
2021 Akkar explosion2021 Akkar explosion
At least 33[failed verification] people were killed by a fuel tanker explosion in Tleil, Akkar District, Lebanon on 15 August 2021. The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and fuel has been in short supply. The survivors were evacuated by the Lebanese Red Cross. An investigation is underway. The fuel tanker had been confiscated by the Lebanese Armed Forces from black marketeers, the fuel was then distributed/taken by the locals. The son of the man whose land the fuel tanker was located on, was later arrested, accused of deliberately causing the explosion. Agencies (2021-08-15). "At least 20 killed and 79 injured in fuel tank explosion in Lebanon". the Guardian. Retrieved 2021-08-15. "Lebanon fuel explosion kills 22 and injures dozens more". The Independent. 2021-08-15. Archived from the original on 2021-08-15. Retrieved 2021-08-15. "Lebanon: At least 20 dead and dozens injured after fuel tank explodes as ...
https://en.wikipedia.org/wiki/2021_Akkar_explosion
Straubing TigersStraubing Tigers
The Straubing Tigers are a professional men's ice hockey team, based in Straubing, Germany, that competes in the Deutsche Eishockey Liga. Straubing plays its home games at the Eisstadion am Pulverturm, which has a capacity of 5,800 spectators. Promoted to the DEL in 2006, and operating with one of the league's smallest budgets, the team could finish no better than twelfth before the 2011-12 DEL season, when it reached the semi-finals of the playoffs. Their greatest success so far is the qualification for the season 2020-21 of the Champions Hockey League. In 1941, the then 14-year-old Max Pielmaier and his friends Max Pellkofer and Harry Poiger founded the first hockey team in Straubing. The first official game took place on the first of February 1942 in Hof and was lost by a score of 0:1. In the following year there were several games against other Bavarian teams. The game against Landshut on 31 January. 1943 was the last game during the second World War, because the young players also had to ...
https://en.wikipedia.org/wiki/Straubing_Tigers
Leina, Saare CountyLeina, Saare County
Leina is a village in Saaremaa Parish, Saare County in western Estonia. Before the administrative reform in 2017, the village was in Pihtla Parish. "Lisa. Asustusüksuste nimistu" (PDF). haldusreform.fin.ee (in Estonian). Rahandusministeerium. Retrieved 5 December 2017. "Saaremaa külad endiste valdade piires". www.saaremaa.ee (in Estonian). Archived from the original on 3 December 2017. Retrieved 5 December 2017. Coordinates: 58°17′10″N 22°46′26″E / 58.28611°N 22.77389°E / 58.28611; 22.77389 v t e (CS1 Estonian-language sources (et), Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Saaremaa Parish, Coordinates on Wikidata, Villages in Saare County, All stub articles, Saare County geography stubs ...
https://en.wikipedia.org/wiki/Leina,_Saare_County
SestiereSestiere
A sestiere (plural: sestieri) is a subdivision of certain Italian towns and cities. The word is from sesto ('sixth'), so it is thus used only for towns divided into six districts. The best-known example is the sestieri of Venice, but Ascoli Piceno, Genoa, Milan and Rapallo, for example, were also divided into sestieri. The medieval Lordship of Negroponte, on the island of Euboea, was also at times divided into six districts, each with a separate ruler, through the arbitration of Venice, which were known as sestieri. The island of Crete, a Venetian colony (the "Kingdom of Candia") from the Fourth Crusade, was also divided into six parts, named after the sestieri of Venice herself, while the capital Candia retained the status of a comune of Venice. The island of Burano north of Venice is also subdivided into sestieri. A variation of the word is occasionally found: the comune of Leonessa, for example, is divided into sesti or sixths. Other Italian towns with fewer than six official districts are ...
https://en.wikipedia.org/wiki/Sestiere
Island ImageIsland Image
The Island Image is a Chesapeake Bay log canoe, built in 1885 at Elliot's Island, Maryland, by Herman Jones and Isaac Moore. She is 29'-8½" long with a beam of 5-10¼", and has a straight, raking stem and a sharp stern. It is privately owned, and races under No. 17. She one of the last 22 surviving traditional Chesapeake Bay racing log canoes that carry on a tradition of racing on the Eastern Shore of Maryland that has existed since the 1840s. She is located at Chestertown, Kent County, Maryland. She was listed on the National Register of Historic Places in 1985. "National Register Information System". National Register of Historic Places. National Park Service. April 15, 2008. "Maryland Historical Trust". ISLAND IMAGE (log canoe). Maryland Historical Trust. 2008-06-14. "Island Image #17 , CBLCSA". Island Image. Chesapeake Bay Log Sailing Canoe Association. 2010-07-24. Archived from the original on 2011-07-08. Retrieved 2010-07-29. ISLAND IMAGE (log canoe), Kent County, including photo in 1984, ...
https://en.wikipedia.org/wiki/Island_Image
RCSB PDB - 1RJT: NMR Structure of CXC Chemokine CXCL11/ITACRCSB PDB - 1RJT: NMR Structure of CXC Chemokine CXCL11/ITAC
NMR structure of CXCR3 binding chemokine CXCL11 (ITAC).. Booth, V., Clark-Lewis, I., Sykes, B.D.. (2004) Protein Sci 13: 2022- ... CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10 ... CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10 ... CXCL11 takes on the canonical chemokine fold but exhibits greater conformational flexibility than has been observed for related ...
https://www.rcsb.org/structure/1RJT
CXCL11 Chemokine | Sustainable Development Goals - Resource Centre
Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway. ...
https://sdgresources.relx.com/cxcl11-chemokine
Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey - Volume 29, Number 2-February 2023 - Emerging...
IFN-γ induces production of CXCL10 and CXCL11, structurally associated chemokines that attract C-X-C chemokine receptor type 3+ ... Five cytokines/chemokines, IFN-α (p = 0.016), CXCL10 (p = 0.016), CXCL11 (p = 0.016), CCL11 (p = 0.016), and CCL2 (p = 0.003), ... Serum Cytokine/Chemokine Levels Cytokine/chemokine values varied both over time and between patient and control groups (Table 3 ... In that period, triglyceride levels negatively correlated with CXCL10 and CXCL11, both chemokines known to cause ...
https://wwwnc.cdc.gov/eid/article/29/2/22-0976_article
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in...Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in...
The systemic administration of erythrocytes with chemokine-encapsulating nanoparticles non-covalently anchored to their surface ... we show that treatment with chemokine-encapsulating nanoparticles that are non-covalently anchored onto the surface of injected ... CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation-a target for novel cancer therapy. Cancer Treat. Rev. 63, 40-47 (2018). ... Homey, B., Muller, A. & Zlotnik, A. Chemokines: agents for the immunotherapy of cancer? Nat. Rev. Immunol. 2, 175-184 (2002). ...
https://www.nature.com/articles/s41551-020-00644-2?error=cookies_not_supported&code=72ee4849-2782-4e94-a6d1-27f2c6f71942
Study on the Mechanisms and Experimental Verification of Cuscuta-Salvia (Tusizi-Danshen) in the Treatment of Polycystic Ovary...Study on the Mechanisms and Experimental Verification of Cuscuta-Salvia (Tusizi-Danshen) in the Treatment of Polycystic Ovary...
CXCL11. C-X-C motif chemokine 11. 135. CXCL2. C-X-C motif chemokine 2 ...
https://www.researchsquare.com/article/rs-642886/v1
CXCL11 Protein - Creative BioMart
CXCL11); is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha ... CXCL11-2159H. Recombinant Human CXCL11 Protein, GST-tagged Wheat Germ. GST. Human. CXCL11-270H. Recombinant Human Chemokine (C- ... Cxcl11-150M. Recombinant Mouse Cxcl11 Protein E.coli. Mouse. Cxcl11-204M. Recombinant Mouse Cxcl11 Protein, His-tagged E.coli. ... CXCL11-280H. Recombinant Human CXCL11 protein E.coli. N/A. Human. CXCL11-297H. Recombinant Human CXCL11, StrepII-tagged Human ...
https://www.creativebiomart.net/symbolsearch_cxcl11.htm
Genes | October 2019 - Browse ArticlesGenes | October 2019 - Browse Articles
Of these DEGs, a number of genes, such as chemokine and T cell surface marker genes, were found to be significantly up- ... Furthermore, we detected the interaction of CXCR4, CXCL11 and miR-9 using dual luciferase reporter assay. Taken together, this ...
https://www.mdpi.com/2073-4425/10/10
Alexa Fluor 647 anti-human CD183 CXCR3 Antibody anti-CD183 - G025H7Alexa Fluor 647 anti-human CD183 CXCR3 Antibody anti-CD183 - G025H7
... is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. ... CXCL9, CXCL10, and CXCL11 Cell Type Dendritic cells, ... Human CXCR3, also known as GPR9, is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. It is a 38 kD seven-pass ... CD Molecules, Cytokine/Chemokine Receptors, GPCR Antigen References 1. Loetscher M, et al. 1996. J. Exp. Med. 184:963.. 2. Cole ... CXC-chemokine receptor, G protein-coupled receptor, seven-pass transmembrane receptor Distribution T cell subset, NK cells, ...
https://www.biolegend.com/en-us/products/alexa-fluor-647-anti-human-cd183-cxcr3-antibody-7582
Human Native ChemokinesHuman Native Chemokines
CXCL11. ITAC. 20ug. CN-13. CXCL11. ITAC. 100ug. CN-13. CXCL11. ITAC. 1mg. CN-13. ... Human Native Chemokines. Almac presents a series of native human chemokines, produced by chemical synthesis to ensure high ... Chemokine & Histone online shop. Comprehensive range of Chemokine and Histone products with worldwide shipping and online ... Chemokine & Histone online shop. Comprehensive range of Chemokine and Histone products with worldwide shipping and online ...
https://www.almacgroup.com/api-chemical-development/human-native-chemokines/
Tillmann Uhlig - Institute of Clinical MedicineTillmann Uhlig - Institute of Clinical Medicine
Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritis. Clinical ... After 24 weeks of treatment, plasma levels of CXCL10, CXCL8, CXCL9, CXCL11 and CXCL13 decreased in all treatment groups except ... However, it is unclear whether pre-treatment chemokine levels can predict disease remission at week 24, and it is not known how ... The plasma concentrations of 14 chemokines were measured at baseline and after 24 weeks of treatment by bead-based immunoassay ...
https://www.med.uio.no/klinmed/english/people/aca/tillmanu/index.html
Frontiers | Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound...Frontiers | Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound...
... suggesting a skin barrier protection role for these chemokines at the tick bite site. In contrast, exogenous treatment of ... showed a novel role of these in vivo exosomes in the inhibition of wound healing via downregulation of C-X-C motif chemokine ... The latter molecule has been shown to metabolically cleave chemokines such as CXCL11 and CXCL12 to regulate the local immune ... Cytokine and chemokine transcript levels were normalized to human beta-actin. Am represents Amblyomma maculatum, Is indicates ...
https://www.frontiersin.org/articles/10.3389/fcell.2020.00554/full
The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ SmokersThe Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers
including the presence of chemokine (C-C motif) ligand 1 (CCL-1) and chemokine (C-X-C motif) ligand 11 (CXCL-11), both ... Based on these data and the fact that T cell-related chemokine levels were elevated in the ELF of HIV1+ smokers with low ( ... R. Montes-Vizuet, A. Vega-Miranda, E. Valencia-Maqueda, M. C. Negrete-García, J. R. Velásquez, and L. M. Teran, "CC chemokine ... P. Van Lint and C. Libert, "Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte ...
https://www.hindawi.com/journals/jir/2016/3463104/
The role of chemokines and cytokines in lung fibrosis | European Respiratory SocietyThe role of chemokines and cytokines in lung fibrosis | European Respiratory Society
... and levels of ELR-negative chemokines CXCL10 and CXCL11 are decreased, leading to an imbalance that tends to favour an ... The role of chemokines and cytokines in lung fibrosis Message Subject (Your Name) has sent you a message from European ... Belperio JA, Dy M, Murray L, et al. The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis. J Immunol 2004; 173: ... The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 1997; 159: 1437- ...
https://err.ersjournals.com/content/17/109/151?ijkey=227e7d3cb6d5eba7573c56b2e541a2d164ed5f59&keytype2=tf_ipsecsha
Medical Science Monitor | Clinical Significance of Serum Chemokines in Esophageal Cancer - Article abstract #916846Medical Science Monitor | Clinical Significance of Serum Chemokines in Esophageal Cancer - Article abstract #916846
The liquid chip (Luminex) technology was applied to detect the expression levels of the above-mentioned serum chemokines in the ... There were no statistically significant differences in chemokine expressions between metastatic esophageal cancer group and non ... The aim of this study was to detect the expression levels of chemokines (CX3CL1, CXCL-11, CXCL-12, CCL3, CCL4, and CCL20) in ... BACKGROUND: The aim of this study was to detect the expression levels of chemokines (CX3CL1, CXCL-11, CXCL-12, CCL3, CCL4, and ...
https://medscimonit.com/abstract/index/idArt/916846
Pellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment | bioRxivPellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment | bioRxiv
... that Peli1-mediated hyperproliferative keratinocytes upregulated the expression and secretion of CCL20 and CXCL11 chemokines ... and chemokines [e.g., CXC ligand [CXCL]8, CXCL10, and chemokine CC ligand [CCL]20] that contribute to the development of ... Bromley SK, Mempel TR, Luster AD (2008) Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 9 ... These T cells in turn secrete mediators (e.g., IL-17a and IL-22) and produce proinflammatory cytokines, chemokines, and others ...
https://www.biorxiv.org/content/10.1101/334433v1.full
Human Chemokine Array Q1 [QAH-CHE-1]Human Chemokine Array Q1 [QAH-CHE-1]
Human Chemokine Array 1 Kit. Detects 40 Human Chemokines. Suitable for all liquid sample types. ... CXCL11 , CXCL12 , CXCL16 , CXCL2 , CXCL3 , CXCL5 , CXCL6 , IFNL1 , IFNL2 , IL17F , IL18BP , IL31 , IL9 , LIF , MIF , MST1 , PF4 ... Quantibody® Human Chemokine Array 1 Kit. Detects 40 Human Chemokines. Suitable for all liquid sample types. ...
https://www.raybiotech.com/quantibody-human-chemokine-array-1-1-slide/?variation_id=107882
December 2017 - Stem cell application on skin cancer research
... demonstrated that STIM1-lacking Compact disc4+ Capital t cells absence Ca2+ inflow upon pleasure with chemokines such as CXCL11 ... One such chemokine is certainly 1374601-40-7 IC50 stromal-derived aspect-1 (SDF-1, also known as chemokine (C-X-C theme) ligand ... or genetics [6]. Chemokine receptor signaling can activate [Ca2+]i height through recruitment and service of phospholipase C-; ... chemokine (C-X-C theme) receptor 4, CXCR4), which is present on the CLL cell surface area, play a crucial function in CLL cell ...
http://www.exposed-skin-care.net/2017/12/
Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy | Journal...Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy | Journal...
RNAdjuvant® was the only one to induce most of the cytokines/chemokines tested with a pronounced Th1 cytokine pattern. ... cytokine and chemokine production was evaluated by Bio-Plex ProTM. Treatment with RNAdjuvant® induced the strongest response in ... α-chemokines (CX3CL1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL16, CXCL2, CXCL5, CXCL6) and β-chemokines (CCL1 CCL11, CCL13, ... Chemokines with highest expression were CXCL10, CXCL11 and CXCL13 as well as CCL20, CCL3 and CCL8. Consistently, CXCL16 and ...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02218-x
Arielle Lyon Langer, M.D. | Harvard Catalyst Profiles | Harvard CatalystArielle Lyon Langer, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Chemokine CXCL11. *Chemokine CXCL9. *Hematinics. Concepts & Ideas. *Knowledge. *Income. *Program Evaluation. *Curriculum ...
https://connects.catalyst.harvard.edu/Profiles/display/person/181836/network/researchareas/categories
DeCSDeCS
Chemokine CXCL11 Entry term(s). CXC Chemokine I TAC CXC Chemokine I-TAC CXC Chemokine, H174 CXCL11 Chemokine CXCL11, Chemokine ... Chimiokine CXCL11 Entry term(s):. CXC Chemokine I TAC. CXC Chemokine I-TAC. CXC Chemokine, H174. CXCL11 Chemokine. CXCL11, ... Chemokine I-TAC, CXC Chemokine, CXCL11 Chemokine, H174 CXC H174 CXC Chemokine Small Inducible Cytokine Subfamily B, Member 11 ... Chemokine I-TAC, CXC. Chemokine, CXCL11. Chemokine, H174 CXC. H174 CXC Chemokine. Small Inducible Cytokine Subfamily B, Member ...
https://decs.bvsalud.org/en/ths/resource/?id=52779
Lipoprotein lipase hydrolysis products induce pro-inflammatory cytokine expression in triple-negative breast cancer cells | BMC...Lipoprotein lipase hydrolysis products induce pro-inflammatory cytokine expression in triple-negative breast cancer cells | BMC...
CXC motif chemokine ligand (CXCL) 1, CXCL11, ICAM-1, interleukin (IL)-4, IL-6, IL-8, and TNF-α (Fig. 1A). No detection or no ... Finally, increased secretion of CXCL11 in MDA-MB-231 cells was unexpected. CXCL11 attracts mononuclear immune cells to the ... CXCL11 is primarily induced by interferon (IFN)-γ [17], yet IFN-γ secretion was not detected in this study possibly because it ... Ben-Baruch A. Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer ...
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-021-05728-z
GSE28737 WT VS BCL6 HET MARGINAL ZONE BCELL DNGSE28737 WT VS BCL6 HET MARGINAL ZONE BCELL DN
CXCL11. 6373. CXCL11. C-X-C motif chemokine ligand 11 [Sou.... CYP27B1. 1594. CYP27B1. cytochrome P450 family 27 subfamily ... ... C-X-C motif chemokine ligand 10 [Sou.... ...
https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE28737_WT_VS_BCL6_HET_MARGINAL_ZONE_BCELL_DN.html
Pivotal Role of Dendritic Cell-derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes |...Pivotal Role of Dendritic Cell-derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes |...
Inflammatory chemokines including CCL3, CXCL9, and CXCL11 were generally produced by granuloma-forming Kupffer cells in our ... CC chemokine receptor (CCR)7+ T cells may remain within T cell areas (6), CCR4+ T cells seem to migrate toward a new wave of ... c) Expression of chemokine mRNAs in CD11c+ DCs isolated from the blood, liver, hepatic, and axillary LNs at day 7 after P. ... c) Expression of chemokine mRNAs in CD11c+ DCs isolated from the blood, liver, hepatic, and axillary LNs at day 7 after P. ...
https://rupress.org/jem/article/195/10/1257/8276/Pivotal-Role-of-Dendritic-Cell-derived-CXCL10-in
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
CXCR3 binds three chemokine ligands, CXCL9, CXCL10 and CXCL11. These ligands display distinct expression patterns and ligand ... CXCL9 and CXCL10 are considered pro-inflammatory chemokines during viral infection, while CXCL11 may induce a tolerizing state ... Quimiocina CXCL10 , Quimiocina CXCL11/metabolismo , Viroses , Animais , Quimiocina CXCL10/genética , Quimiocina CXCL11/genética ... While CXCL11 expression did not modify acute antiviral responses, this study provides a new tool to understand the role of ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:Groom,+Joanna+R
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11. HN - 2008(1998) BX - Antigens, CD183 BX ... CCL3 Chemokine BX - CCL3L1 Chemokine BX - CCL3L2 Chemokine BX - CCL3L3 Chemokine BX - Chemokine CCL3L1 BX - Chemokine CCL3L2 BX ... CCL4L1 Chemokine BX - CCL4L2 Chemokine BX - Chemokine CCL4L1 BX - Chemokine CCL4L2 MH - Chemokine CCL11 UI - D054413 MN - ... HN - 2008(1987) BX - CXCL10 Chemokine MH - Chemokine CXCL11 UI - D054371 MN - D12.644.276.374.200.120.550 MN - D12.776.467.374. ...
https://decs.bvs.br/I/dcsnew2008.txt
LEGENDplex™ Mouse CXCL11 (ITAC) Capture Bead A6, 13X, CXCL11LEGENDplex™ Mouse CXCL11 (ITAC) Capture Bead A6, 13X, CXCL11
Mouse Proinflammatory Chemokine Panel 2 Standard contains 8 mouse proteins including Eotaxin-2, MCP-2, ITAC, Fractalkine, MCP-3 ... Chemokine Panel 2 Standard. 741145 LEGENDplex™ Buffer Set O. 741069 LEGENDplex™ MU Proinflam. Chemokine Panel 2 Detection ...
https://production-dynamicweb.biolegend.com/fr-fr/products/legendplex-mouse-cxcl11-itac-capture-bead-a6-13x-20343
Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey - Volume 29, Number 2-February 2023 - Emerging...
IFN-γ induces production of CXCL10 and CXCL11, structurally associated chemokines that attract C-X-C chemokine receptor type 3+ ... Five cytokines/chemokines, IFN-α (p = 0.016), CXCL10 (p = 0.016), CXCL11 (p = 0.016), CCL11 (p = 0.016), and CCL2 (p = 0.003), ... Serum Cytokine/Chemokine Levels Cytokine/chemokine values varied both over time and between patient and control groups (Table 3 ... In that period, triglyceride levels negatively correlated with CXCL10 and CXCL11, both chemokines known to cause ...
https://wwwnc-origin.cdc.gov/eid/article/29/2/22-0976
CXCL11 and PPBP - Wiki-MPMCXCL11 and PPBP - Wiki-MPM
CXCL11. PPBP. Description. C-X-C motif chemokine ligand 11. pro-platelet basic protein. ... 32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 ...
https://hagrid.dbmi.pitt.edu/wiki-MPM/index.php/pair/view/6373/5473
IMP: Integrative Multi-species Prediction
CXCL11. chemokine (C-X-C motif) ligand 11. 0.025. LY6E. lymphocyte antigen 6 complex, locus E. 0.025. ...
http://imp.princeton.edu/predictions/process/human-context-global/4566/?gene=2802
History Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that - DNA Topoisomerase - Synthesis and Structure...
CXCL4 CXCL9 CXCL10 and CXCL11) CXC chemokines [7]. ELR+ CXC chemokines play a significant function in tumor development and ... History Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that. * Post author By conferencedequebec ... The CXC chemokine family is the unique group of cytokines known for their ability LY2886721 to act within a disparate way in ... History Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and ...
http://www.conferencedequebec.org/2017/05/20/history-interleukin-8-il-8cxcl-8-is-a-prototype-of-the-elrcxc-chemokines-that/
CXCR3CXCL10 and CXCL11ReceptorReceptorsMotif chemokine liCXCL9 and CXCL11Cytokines and chemokinesTumorInflammatory cytokinesITACProteinsCX3CL1UpregulationCXCL12CXCL16NanoparticlesBiologicalGENECCR2InterleukinAngiostaticInterferonSerumInduceLymphocyteAngiogenicRecruitmentInflammationExpressionDifferencesFamilyHumanCancerImmuneLungRolesStructuresCellsStructureRoleProduction
CXCR313
  • CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10). (rcsb.org)
  • The chemokine receptor CXCR3 is expressed on immune cells to co-ordinate lymphocyte activation and migration. (bvsalud.org)
  • CXCR3 binds three chemokine ligands, CXCL9, CXCL10 and CXCL11. (bvsalud.org)
  • 3][4] CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3. (elisa-kits.de)
  • Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia. (cdc.gov)
  • The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. (spandidos-publications.com)
  • Loetscher M, Loetscher P, Brass N, Meese E and Moser B: Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization. (spandidos-publications.com)
  • Qin S, Rottman JB, Myers P, et al: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. (spandidos-publications.com)
  • Cole KE, Strick CA, Paradis TJ, et al: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (spandidos-publications.com)
  • Clark-Lewis I, Mattioli I, Gong JH and Loetscher P: Structure-function relationship between the human chemokine receptor CXCR3 and its ligands. (spandidos-publications.com)
  • CXCR3 is a G protein-coupled, seven-transmembrane receptor that binds and is activated by the three IFN-gamma-inducible chemokines of the CXC family named CXCL9, CXCL10, and CXCL11. (cnrs.fr)
  • The receptor of this chimiokine is CXCR3 that is shared with CXCL9 and CXCL11. (bertin-bioreagent.com)
  • The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (bertin-bioreagent.com)
CXCL10 and CXCL114
  • 1. Urinary mRNA levels of CXCL10 and CXCL11 are decreased, and those of collagen I A1 chain and fibronectin are increased in diabetic nephropathy. (igib.res.in)
  • It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. (elisa-kits.de)
  • Kanda N, Shimizu T, Tada Y and Watanabe S: IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes. (spandidos-publications.com)
  • Kanda N and Watanabe S: Prolactin enhances interferon-gamma induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. (spandidos-publications.com)
Receptor8
  • Interferon pathway-related cytokines/chemokines, including interleukin (IL) 18, macrophage inflammatory protein 3α, and IL-33, were elevated, but tumor necrosis factor-α, IL-6, CXCL8 (formerly IL-8), and cytokines acting through C-C chemokine receptor 2 and CCR5 were lower among case-patients than controls. (cdc.gov)
  • We selected most pathways CXCL11 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. (creativebiomart.net)
  • Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal. (biolegend.com)
  • Cytokine receptors expressed by Th2 cells include CC chemokine receptor (CCR)4, CCR8 and CXCR4. (ersjournals.com)
  • Conclusion Our results indicated that this polymorphisms in IL-8 and CXCR2 genes are associated with increased breast cancer risk as well as disease progress supporting our hypothesis for IL-8 and ELR+CXC chemokine receptor (CXCR2) involvement in breast cancer pathogenesis. (conferencedequebec.org)
  • Loetscher M, Gerber B, Loetscher P, et al: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (spandidos-publications.com)
  • Sallusto F, Lenig D, Mackay CR and Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. (spandidos-publications.com)
  • A CXCR6 receptor-binding chemokine that functions as a scavenger receptor for oxidized low density lipoprotein (OxLDL) when expressed by MACROPHAGES. (jefferson.edu)
Receptors4
  • Does staining at room temperature or even at 37°C help for checking chemokine receptors expression? (biolegend.com)
  • Certain chemokine receptors predominate on either Th1 or Th2 cells. (ersjournals.com)
  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. (igib.res.in)
  • Bonecchi R, Bianchi G, Bordignon PP, et al: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. (spandidos-publications.com)
Motif chemokine li2
  • Another reported that IL-10, C-X-C motif chemokine ligand 10 (CXCL-10, formerly IFN-γ inducible protein 10) and CC chemokine ligand 2 (CCL2, formerly monocyte chemoattractant protein 1) levels were higher in patients with high viral loads ( 12 ), but patients with severe disease had higher levels of CXCL10 and CCL2 than did patients with less-severe cases. (cdc.gov)
  • 6-MSITC inhibited interleukin (IL)-6 and C-X-C motif chemokine ligand 10 (CXCL10) production in TNF-α-stimulated TR146 cells, which are a human oral epithelial cell line. (tokushima-u.ac.jp)
CXCL9 and CXCL111
  • The researchers discovered that levels of two chemokines (known as CXCL9 and CXCL11), which are responsible for the recruitment of those CD8+ T cells that kill off cancer were increased in mice that exercised. (easyhealthoptions.com)
Cytokines and chemokines2
  • The fetal outcomes, the apoptosis in placenta and JEG-3 cells, the expression of inflammatory cytokines and chemokines including tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein-2 (MIP-2) and chemokine (C-X-C motif) ligand 1 (KC), and expression of endoplasmic reticulum (ER) stress markers were evaluated. (academic-accelerator.com)
  • Human Qbeads Inflammation Panel Kit allows the measurement of seven human cytokines and chemokines from either serum or in vitro samples. (sartorius.com)
Tumor3
  • ELR+ CXC chemokines play a significant function in tumor development and progression in several tumor model systems [8]. (conferencedequebec.org)
  • Analysis of publicly available tumor transcriptome profiles showed that the chemokine CCL5 was strongly associated with immune cell infiltration in various human cancers. (biomedcentral.com)
  • Among these chemokines, the tumor cell-derived chemokines CXCL9 and CXCL10 are critical in attracting CD8 + T lymphocytes to tumor tissues [ 6 , 7 ]. (biomedcentral.com)
Inflammatory cytokines1
  • PAMPs) and induce the innate immune response by activation of a signaling cascade resulting in the upregulation of inflammatory cytokines, chemokines, and type I IFNs. (biomedcentral.com)
ITAC1
  • Unlike related chemokines such as IP-10 and IL-8, ITAC does not appear to form dimers at millimolar concentrations. (rcsb.org)
Proteins4
  • Also, other proteins which involved in the same pathway with CXCL11 were listed below. (creativebiomart.net)
  • Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL11 itself. (creativebiomart.net)
  • We selected most functions CXCL11 had, and list some proteins which have the same functions with CXCL11. (creativebiomart.net)
  • Chemokines are a family of small heparin-binding proteins that mediate immune cell trafficking [ 5 ]. (biomedcentral.com)
CX3CL11
  • The aim of this study was to detect the expression levels of chemokines (CX3CL1, CXCL-11, CXCL-12, CCL3, CCL4, and CCL20) in the serum of esophageal cancer patients and a normal control group, and to explore the correlations of those expression levels with the pathological type, progression, and metastasis of esophageal cancer. (medscimonit.com)
Upregulation2
  • Our data showed a novel role of these in vivo exosomes in the inhibition of wound healing via downregulation of C-X-C motif chemokine ligand 12 (CXCL12) and upregulation of interleukin-8 (IL-8). (frontiersin.org)
  • Combination treatment led to upregulation of immune response genes, including multiple chemokine genes such as CCL5, in macrophages, and downregulation of extracellular matrix genes in fibroblasts. (biomedcentral.com)
CXCL121
  • Inhibition of IL-8 or CXCL12 further delayed exosome-mediated cell migration, wound healing, and repair process, suggesting a skin barrier protection role for these chemokines at the tick bite site. (frontiersin.org)
CXCL163
  • Chemokine CXCL16" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • This graph shows the total number of publications written about "Chemokine CXCL16" by people in this website by year, and whether "Chemokine CXCL16" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Chemokine CXCL16" by people in Profiles. (jefferson.edu)
Nanoparticles1
  • Here, by taking advantage of the preferential colocalization of intravenously administered erythrocytes with metastases in the lungs, we show that treatment with chemokine-encapsulating nanoparticles that are non-covalently anchored onto the surface of injected erythrocytes results in local and systemic tumour suppression in mouse models of lung metastasis. (nature.com)
Biological2
  • Almac presents a series of native human chemokines, produced by chemical synthesis to ensure high purity and reliable biological function. (almacgroup.com)
  • However, the biological mechanisms of chemokine expression in NB cells are not yet known. (biomedcentral.com)
GENE1
  • MIG, a member of the CXC subfamily of chemokines that lack the ELR domain, was initially identified as a lymphokine-activated gene in mouse macrophages. (elisa-kits.de)
CCR21
  • Interferon pathway activation and cytokines/chemokines acting through CCR2 and CCR5 improved health results among children with severe CCHF. (cdc.gov)
Interleukin1
  • History Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. (conferencedequebec.org)
Angiostatic1
  • Furthermore, evidence has emerged regarding an imbalance between angiogenic and angiostatic chemokine levels, leading to an overall angiogenic pattern of expression in both animal models and tissue specimens from IPF patients. (ersjournals.com)
Interferon1
  • A CXC chemokine that is induced by GAMMA-INTERFERON. (bvsalud.org)
Serum1
  • The liquid chip (Luminex) technology was applied to detect the expression levels of the above-mentioned serum chemokines in the two groups. (medscimonit.com)
Induce1
  • RNAdjuvant ® was the only one to induce most of the cytokines/chemokines tested with a pronounced Th1 cytokine pattern. (biomedcentral.com)
Lymphocyte1
Angiogenic2
  • Several members from the CXC chemokine are powerful promoters of angiogenesis whereas others inhibit the angiogenic procedure. (conferencedequebec.org)
  • The disparity in angiogenic activity among CXC chemokine family is related to three amino acidity structural domains on the N terminus Glu-Leu-Arg (ELR) which exists in angiogenic (i.e. (conferencedequebec.org)
Recruitment2
  • Anti-PD-L1 induced the expression of several chemokines that are associated with the recruitment of cytotoxic T cells, with a further increase in expression after combination therapy. (biomedcentral.com)
  • Meanwhile, the overexpression of B3GALT4 increased the recruitment of CD8 + T lymphocytes via the chemokines CXCL9 and CXCL10. (biomedcentral.com)
Inflammation1
  • The cytokines/chemokines included are implicated in inflammatory responses to disease states including autoimmune diseases, chronic inflammation, and infections, including viral infections such as COVID-19. (sartorius.com)
Expression2
  • expression of a second Th1-attracting chemokine, CXCL11, was not elevated. (aai.org)
  • This is the first comparative study of TSLP expression in the asthmatic bronchus and delineates the cells expressing TSLP and Th1- and Th2-attracting chemokines. (aai.org)
Differences2
  • The structure of CXCL11 was determined using solution NMR to allow comparison with that of CXCL10 and help elucidate the source of the differences. (rcsb.org)
  • There were no statistically significant differences in chemokine expressions between metastatic esophageal cancer group and non-metastatic esophageal cancer group ( P >0.05). (medscimonit.com)
Family1
  • The CXC chemokine family is the unique group of cytokines known for their ability LY2886721 to act within a disparate way in angiogenesis legislation. (conferencedequebec.org)
Human2
Cancer1
  • It is well documented that epigenetic and genetic alterations including transcription factors, growth factors, cytokines, chemokines and proteases are critically involved in cancer progression under specific microenvironment [ 2 ]. (biomedcentral.com)
Immune1
  • Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. (igib.res.in)
Lung1
  • Photomicrograph showing immunolocalisation of CC chemokine ligand (CCL)17 from idiopathic pulmonary fibrosis (IPF) lung tissue specimens. (ersjournals.com)
Roles1
Structures1
  • Swaminathan GJ, Holloway DE, Colvin RA, et al: Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. (spandidos-publications.com)
Cells1
  • A CXC chemokine that is predominantly expressed in EPITHELIAL CELLS . (nih.gov)
Structure1
  • The origin for this behavior can be found in the solution structure, which indicates a beta-bulge in beta-strand 1 that distorts the dimerization interface used by other CXC chemokines. (rcsb.org)
Role2
  • Therefore, numerous questions exist regarding the role and importance of chemokines and cytokines in pulmonary fibrosis. (ersjournals.com)
  • Zlotnik A and Yoshie O: Chemokines: a new classification system and their role in immunity. (spandidos-publications.com)
Production2
  • cytokine and chemokine production was evaluated by Bio-Plex ProTM. (biomedcentral.com)
  • Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that induces production of Th2-attracting chemokines. (aai.org)
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in...
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in... (nature.com)
Study on the Mechanisms and Experimental Verification of Cuscuta-Salvia (Tusizi-Danshen) in the Treatment of Polycystic Ovary...
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Transcriptome Analysis Reveals Distinct Gene Expression Profiles in Eosinophilic and Noneosinophilic Chronic Rhinosinusitis...
Transcriptome Analysis Reveals Distinct Gene Expression Profiles in Eosinophilic and Noneosinophilic Chronic Rhinosinusitis... (nature.com)
CXCL11 Protein - Creative BioMart
CXCL11 Protein - Creative BioMart (creativebiomart.net)
Alexa Fluor 647 anti-human CD183 CXCR3 Antibody anti-CD183 - G025H7
Alexa Fluor 647 anti-human CD183 CXCR3 Antibody anti-CD183 - G025H7 (biolegend.com)
Tillmann Uhlig - Institute of Clinical Medicine
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Frontiers | Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound...
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The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers
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Human Native Chemokines
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Frontiers | Indoleamine 2,3-Dioxygenase Activity in Chlamydia muridarum and Chlamydia pneumoniae Infected Mouse Lung Tissues
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CXCL11 Chemokine | Sustainable Development Goals - Resource Centre
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Pellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment | bioRxiv
Pellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment | bioRxiv (biorxiv.org)
Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy | Journal...
Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy | Journal... (translational-medicine.biomedcentral.com)
Itaconate Inhibits TET DNA Dioxygenases to Dampen Inflammatory Responses | Research Square
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Arielle Lyon Langer, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
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Pivotal Role of Dendritic Cell-derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes |...
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CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and...
CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and... (jhoonline.biomedcentral.com)
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer...
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Display 50 results per page
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2013 NIH Summer Poster Day Participants | National Eye Institute
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Plasmacytoid Dendritic Cells and Immunotherapy in Multiple Sclerosis
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MeSH Browser
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These highlights do not include all the information needed to use KIMMTRAK® safely and effectively. See full prescribing...
These highlights do not include all the information needed to use KIMMTRAK® safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)
DailyMed - KIMMTRAK- tebentafusp injection, solution, concentrate
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