Chemokine CX3CL1
A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. The membrane form of the protein may also play a role in cell adhesion.
Chemokines, CX3C
Receptors, Chemokine
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Chemokine CCL5
A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.
Chemokine CCL2
Chemokine CXCL12
Chemokine CXCL10
Chemokines
Chemokine CXCL1
Chemokine CCL4
Chemokine CCL21
Chemokine CCL22
Chemokine CCL3
Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation. (1/353)
Fractalkine is a novel multidomain protein expressed on the surface of activated endothelial cells. Cells expressing the chemokine receptor CX3CR1 adhere to fractalkine with high affinity, but it is not known if adherence requires G-protein activation and signal transduction. To investigate the cell adhesion properties of fractalkine, we created mutated forms of CX3CR1 that have little or no ability to transduce intracellular signals. Cells expressing signaling-incompetent forms of CX3CR1 bound rapidly and with high affinity to immobilized fractalkine in both static and flow assays. Video microscopy revealed that CX3CR1-expressing cells bound more rapidly to fractalkine than to VCAM-1 (60 versus 190 ms). Unlike VCAM-1, fractalkine did not mediate cell rolling, and after capture on fractalkine, cells did not dislodge. Finally, soluble fractalkine induced intracellular calcium fluxes and chemotaxis, but it did not activate integrins. Taken together these data provide strong evidence that CX3CR1, a seven-transmembrane domain receptor, mediates robust cell adhesion to fractalkine in the absence of G-protein activation and suggest a novel role for this receptor as an adhesion molecule. (+info)Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. (2/353)
Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization: fractalkine is expressed constitutively in neurons and is up-regulated by TNF-alpha and IL-1beta in astrocytes. Expression of its specific receptor, CX3C-R1, is restricted to astrocytes and microglia. We have analyzed the functional correlates of this expression and demonstrate that fractalkine induces microglial cell migration and activation. However, the activity of this chemokine on astrocytes may also be highly relevant in inducing astrocyte-microglia cell interactions through cytokine/mediator release leading to microglial activation. (+info)Inflammatory agents regulate in vivo expression of fractalkine in endothelial cells of the rat heart. (3/353)
Fractalkine is distinguished structurally from other chemokines in that it contains a mucin-like stalk that tethers a CX3C chemokine module to a transmembrane-spanning region; its expression in cultured endothelial cells has been shown to be up-regulated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1). The purpose of this study was to determine whether fractalkine is expressed, in a proinflammatory agent-regulated manner, by cardiac endothelial cells in vivo. Steady state levels of fractalkine mRNA were increased in rat cardiac tissues after in vivo treatment with lipopolysaccharide (LPS), IL-1, or TNF-alpha. In situ hybridization and immunohistochemical analysis revealed that endothelial cells of the coronary vasculature and endocardium were the principal source of proinflammatory agent-inducible fractalkine, although some fractalkine immunoreactivity was also found on the myocytes. These data are the first demonstration of in vivo cardiac endothelial cell fractalkine expression and regulation by proinflammatory agents such as LPS, IL-1, or TNF-alpha. Cardiac endothelial cell-expressed fractalkine may contribute to the influx of leukocytes into the heart during inflammation. (+info)Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. (4/353)
HIV-1 infection of the brain results in chronic inflammation, contributing to the neuropathogenesis of HIV-1 associated neurologic disease. HIV-1-infected mononuclear phagocytes (MP) present in inflammatory infiltrates produce neurotoxins that mediate inflammation, dysfunction, and neuronal apoptosis. Neurologic disease is correlated with the relative number of MP in and around inflammatory infiltrates and not viral burden. It is unclear whether these cells also play a neuroprotective role. We show that the chemokine, fractalkine (FKN), is markedly up-regulated in neurons and neuropil in brain tissue from pediatric patients with HIV-1 encephalitis (HIVE) compared with those without HIVE, or that were HIV-1 seronegative. FKN receptors are expressed on both neurons and microglia in patients with HIVE. These receptors are localized to cytoplasmic structures which are characterized by a vesicular appearance in neurons which may be in cell-to-cell contact with MPs. FKN colocalizes with glutamate in these neurons. Similar findings are observed in brain tissue from an adult patient with HIVE. FKN is able to potently induce the migration of primary human monocytes across an endothelial cell/primary human fetal astrocyte trans-well bilayer, and is neuroprotective to cultured neurons when coadministered with either the HIV-1 neurotoxin platelet activating factor (PAF) or the regulatory HIV-1 gene product Tat. Thus focal inflammation in brain tissue with HIVE may up-regulate neuronal FKN levels, which in turn may be a neuroimmune modulator recruiting peripheral macrophages into the brain, and in a paracrine fashion protecting glutamatergic neurons. (+info)Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. (5/353)
Fractalkine (FKN), a CX(3)C chemokine/mucin hybrid molecule on endothelium, functions as an adhesion molecule to capture and induce firm adhesion of a subset of leukocytes in a selectin- and integrin-independent manner. We hypothesized that the FKN mucin domain may be important for its function in adhesion, and tested the ability of secreted alkaline phosphatase (SEAP) fusion proteins containing the entire extracellular region (FKN-SEAP), the chemokine domain (CX3C-SEAP), or the mucin domain (mucin-SEAP) to support firm adhesion under flow. CX3C-SEAP induced suboptimal firm adhesion of resting peripheral blood mononuclear cells, compared with FKN-SEAP, and mucin-SEAP induced no firm adhesion. CX3C-SEAP and FKN-SEAP bound to CX(3)CR1 with similar affinities. By electron microscopy, fractalkine was 29 nm in length with a long stalk (mucin domain), and a globular head (CX(3)C). To test the function of the mucin domain, a chimeric protein replacing the mucin domain with a rod-like segment of E-selectin was constructed. This chimeric protein gave the same adhesion of peripheral blood mononuclear cells as intact FKN, both when immobilized on glass and when expressed on the cell surface. This implies that the function of the mucin domain is to provide a stalk, extending the chemokine domain away from the endothelial cell surface to present it to flowing leukocytes. (+info)Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. (6/353)
Fractalkine is a unique chemokine that combines properties of both chemoattractants and adhesion molecules. Fractalkine mRNA expression has been observed in the intestine. However, the role of fractalkine in the healthy intestine and during inflammatory mucosal responses is not known. Studies were undertaken to determine the expression and function of fractalkine and the fractalkine receptor CX3CR1 in the human small intestinal mucosa. We identified intestinal epithelial cells as a novel source of fractalkine. The basal expression of fractalkine mRNA and protein in the intestinal epithelial cell line T-84 was under the control of the inflammatory mediator IL-1beta. Fractalkine was shed from intestinal epithelial cell surface upon stimulation with IL-1beta. Fractalkine localized with caveolin-1 in detergent-insoluble glycolipid-enriched membrane microdomains in T-84 cells. Cellular distribution of fractalkine was regulated during polarization of T-84 cells. A subpopulation of isolated human intestinal intraepithelial lymphocytes expressed the fractalkine receptor CX3CR1 and migrated specifically along fractalkine gradients after activation with IL-2. Immunohistochemistry demonstrated fractalkine expression in intestinal epithelial cells and endothelial cells in normal small intestine and in active Crohn's disease mucosa. Furthermore, fractalkine mRNA expression was significantly up-regulated in the intestine during active Crohn's disease. This study demonstrates that fractalkine-CX3CR1-mediated mechanism may direct lymphocyte chemoattraction and adhesion within the healthy and diseased human small intestinal mucosa. (+info)Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. (7/353)
Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS. (+info)Fractalkine-mediated endothelial cell injury by NK cells. (8/353)
Endothelial cells (ECs) are primary targets of immunological attack, and their injury can lead to vasculopathy and organ dysfunction in vascular leak syndrome and in rejection of allografts or xenografts. A newly identified CX3C-chemokine, fractalkine, expressed on activated ECs plays an important role in leukocyte adhesion and migration. In this study we examined the functional roles of fractalkine on NK cell activity and NK cell-mediated endothelial cell injury. Freshly separated NK cells expressed the fractalkine receptor (CX3CR1) determined by FACS analysis and efficiently adhered to immobilized full-length fractalkine, but not to the truncated forms of the chemokine domain or mucin domain, suggesting that fractalkine functions as an adhesion molecule on the interaction between NK cells and ECs. Soluble fractalkine enhanced NK cell cytolytic activity against K562 target cells in a dose- and time-dependent manner. This enhancement correlated well with increased granular exocytosis from NK cells, which was completely inhibited by the G protein inhibitor, pertussis toxin. Transfection of fractalkine cDNA into ECV304 cells or HUVECs resulted in increased adhesion of NK cells and susceptibility to NK cell-mediated cytolysis compared with control transfection. Moreover, both enhanced adhesion and susceptibility of fractalkine-transfected cells were markedly suppressed by soluble fractalkine or anti-CX3CR1 Ab. Our results suggest that fractalkine plays an important role not only in the binding of NK cells to endothelial cells, but also in NK cell-mediated endothelium damage, which may result in vascular injury. (+info)
Chemokine
CXCR that bind CXC chemokines, CCR that bind CC chemokines, CX3CR1 that binds the sole CX3C chemokine (CX3CL1), and XCR1 that ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... or d-chemokines). The only CX3C chemokine discovered to date is called fractalkine (or CX3CL1). It is both secreted and ...
CX3CR1
As the name suggests, this receptor binds the inflammatory chemokine CX3CL1 (also called neurotactin in mice or fractalkine in ... CX3C motif chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a ... "Entrez Gene: chemokine (C-X3-C motif) receptor 1". Archived from the original on 2022-09-08. Retrieved 2017-10-29. Pawelec P, ... CX3CL1/CX3CR1 axis role in neurvous system is to mediate communication between microglia, neuroglia and neurons for regulation ...
CD84
"The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo". The ...
Neuropathic pain
... source of these cues may include neurons secreting chemokines such as CCL21 and surface immobilized chemokines such as CX3CL1. ...
Role of microglia in disease
Fractalkine (CX3CL1) is the exclusive ligand for CX3CR1 and is made as a transmembrane glycoprotein from which a chemokine can ... Chemokines are divided into four main subfamilies: C, CC, CXC, and CX3C. Microglial cells are sources of some chemokines and ... The chemokines CCL5/RANTES, CCL3/MIP-1α, CCL4/MIP-1β, all of which bind to CCR5, are inhibitory to HIV-1 replication in ... Chemokines are cytokines that stimulate directional migration of inflammatory cells in vitro and in vivo. ...
CCL22
The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17. GRCh38: ... 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764-8. ... 2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and ... Campbell JD, Stinson MJ, Simons FE, HayGlass KT (2003). "Systemic chemokine and chemokine receptor responses are divergent in ...
CX3CL1
... with none in CC chemokines and only one intervening amino acid in CXC chemokines. CX3CL1 is produced as a long protein (with ... CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Its gene is located on ... Fractalkine, also known as chemokine (C-X3-C motif) ligand 1, is a protein that in humans is encoded by the CX3CL1 gene. ... Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of ...
Lisa Robinson (scientist)
"Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine, CX3CL1, yet enhances CX3CL1- ... "Constitutive endocytosis of the chemokine, CX3CL1, prevents its degradation by cell surface metalloproteases." Journal of ... "Expression and targeting of CX3CL1 (Fractalkine) in Renal Tubular Epithelial Cells." Journal of the American Society of ...
K. Christopher Garcia
... bound to its chemokine ligand, fractalkine (CX3CL1). The US28-Fractalkine structure was one of the first reports to visualize a ... In more recent studies, the lab has engineered biased chemokine ligands and shown that GPCR activation is governed by ligands ... "Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy". eLife. 7. doi:10.7554/ ... Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity Structural basis for chemokine recognition ...
Index of immunology articles
CR6261 CroFab Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 ... Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... 7 Calreticulin Cancer immunology Cancer immunoprevention Cancer immunotherapy Cantuzumab ravtansine Cathelicidin CC chemokine ...
CCL17
In humans the gene for CCL17 is located on chromosome 16 along with other chemokines including CCL22 and CX3CL1. GRCh38: ... "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". ... CCL17 is one of the few chemokines that are not stored in the body, except in the thymus; these chemokines are made when needed ... CCL17 as well as its partner chemokine CCL22 induce chemotaxis in T-helper cells. They do this by binding to CCR4, a chemokine ...
Outline of immunology
Cytokine Chemokines CC chemokines CXC chemokines C chemokines XCL1 XCL2 CX3C chemokines CX3CL1 (Fractalkine, Neurotactin) ... CXC chemokine receptors (CXCRs) C chemokine receptors (XCRs) XCR1 CX3C chemokine receptors (CX3CRs) CX3CR1 (Fractalkine ... Trimeric cytokine receptors Chemokine receptors - 7-transmembrane G protein-coupled receptors CC chemokine receptors (CCRs) ...
Microglia
The deletion of CX3CL1, a highly expressed sensome gene, in rodent models of Rett syndrome resulted in improved health and ... As part of their response they secrete cytokines, chemokines, prostaglandins, and reactive oxygen species, which help to direct ...
2014 Ju-Jitsu World Championships
The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...
Bolley Johnson
Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...
Don't Say No
... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...
Dewoitine D.371
The Dewoitine 37 was the first of a family of 1930s French-built monoplane fighter aircraft. The D.37 was a single-seat aircraft of conventional configuration. Its fixed landing gear used a tailskid. The open cockpit was located slightly aft of the parasol wing. The radial engine allowed for a comparatively wide fuselage and cockpit. Design of this machine was by SAF-Avions Dewoitine but owing to over work at that companies plant at the time, manufacture of the D.37/01 was transferred to Lioré et Olivier. They were high-wing monoplanes of all-metal construction with valve head blisters on their engine cowlings. The first prototype flew in October 1931. Flight testing resulted in the need for multiple revisions in both engine and airframe, so it was February 1934 before the second prototype flew. Its performance prompted the French government to order for 28 for the Armée de l'Air and Aéronavale. The Lithuanian government ordered 14 that remained in service with their Air Force until 1936, ...
Noor-ul-Ain
The Noor-ul-Ain (Persian: نور العين, lit. 'the light of the eye') is one of the largest pink diamonds in the world, and the centre piece of the tiara of the same name. The diamond is believed to have been recovered from the mines of Golconda, Hyderabad in India. It was first in possession with the nizam Abul Hasan Qutb Shah, later it was given as a peace offering to the Mughal emperor Aurangazeb when he defeated him in a siege. It was brought into the Iranian Imperial collection after the Persian king Nader Shah Afshar looted Delhi in the 18th century.[citation needed] The Noor-ul-Ain is believed to have once formed part of an even larger gem called the Great Table diamond. That larger diamond is thought to have been cut in two, with one section becoming the Noor-ul-Ain and the other the Daria-i-Noor diamond. Both of these pieces are currently part of the Iranian Crown Jewels. The Noor-ul-Ain is the principal diamond mounted in a tiara of the same name made for Iranian Empress Farah ...
Benoist Land Tractor Type XII
The Benoist Land Tractor Type XII was one of the first enclosed cockpit, tractor configuration aircraft built. Benoist used "Model XII" to several aircraft that shared the same basic engine and wing design, but differed in fuselage and control surfaces. The Type XII was a tractor-engined conversion of the model XII headless pusher aircraft that resembled the Curtiss pusher aircraft. Demonstration pilots used Benoist aircraft to demonstrate the first parachute jumps, and the tractor configuration was considered much more suitable for the task. The first example named the "Military Plane" had a small box frame covered fuselage that left the occupants mostly exposed to the wind. The later model XII "Cross Country Plane" had a full fuselage that occupants sat inside of. The first tractor biplane used a wooden fuselage with a small seat on top. The wings were covered with a Goodyear rubberized cloth. The first model XII was built in the spring of 1912. On 1 March 1912, Albert Berry used a headless ...
Santa Cruz Barillas
... (also known as Yalmotx in Qʼanjobʼal) is a town, with a population of 17,166 (2018 census), and a municipality in the Guatemalan department of Huehuetenango. It is situated at 1450 metres above sea level. It covers a terrain of 1,174 km². The annual festival is April 29-May 4. Barillas has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round and extremely heavy rainfall from June to August. Citypopulation.de Population of departments and municipalities in Guatemala Citypopulation.de Population of cities & towns in Guatemala "Climate: Barillas". Climate-Data.org. Retrieved July 26, 2020. Muni in Spanish Website of Santa Cruz Barillas Coordinates: 15°48′05″N 91°18′45″W / 15.8014°N 91.3125°W / 15.8014; -91.3125 v t e (Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no coordinates, Articles containing Q'anjob'al-language text, Coordinates on Wikidata, ...
Maria Margaret Pollen
Maria Margaret La Primaudaye Pollen (10 April 1838 - c. 1919), known as Minnie, was a decorative arts collector. As Mrs John Hungerford Pollen, she became known during the early-twentieth century as an authority on the history of textiles, publishing Seven Centuries of Lace in 1908. Maria Margaret La Primaudaye was born into a Huguenot family on 10 April 1838, the third child of the Revd Charles John La Primaudaye, a descendant of Pierre de La Primaudaye. She was educated in Italy. Her family converted to Catholicism in 1851, and it was in Rome that her father met another recent English convert, John Hungerford Pollen, previously an Anglican priest and a decorative artist. She became engaged to Pollen, who was then seventeen years her senior, in the summer of 1854, and was married in the church of Woodchester monastery, near Stroud, Gloucester, on 18 September 1855. The Pollens initially settled in Dublin, where John Hungerford Pollen had been offered the professorship of fine arts at the ...
Ronald Fogleman
Ronald Robert Fogleman (born January 27, 1942) is a retired United States Air Force general who served as the 15th Chief of Staff of the Air Force from 1994 to 1997 and as Commanding General of the United States Transportation Command from 1992 to 1994. A 1963 graduate from the United States Air Force Academy, he holds a master's degree in military history and political science from Duke University. A command pilot and a parachutist, he amassed more than 6,800 flying hours in fighter, transport, tanker and rotary wing aircraft. He flew 315 combat missions and logged 806 hours of combat flying in fighter aircraft. Eighty of his missions during the Vietnam War were as a "Misty FAC" in the F-100F Super Sabre at Phù Cát Air Base, South Vietnam between 25 December 1968 and 23 April 1969. Fogleman was shot down in Vietnam in 1968, while piloting an F-100. He was rescued by clinging to an AH-1 Cobra attack helicopter that landed at the crash site. In early assignments he instructed student pilots, ...
Peachtree Street (song)
Peachtree Street" is a 1950 song co-written and recorded by Frank Sinatra in a duet with Rosemary Clooney. The song was released as a Columbia Records single. Frank Sinatra co-wrote the song with Leni Mason and Jimmy Saunders. Mason composed the music while Sinatra and Saunders wrote the lyrics. The song was arranged by George Siravo The song was released as an A side Columbia 10" 78 single, Catalog Number 38853, Matrix Number CO-43100-1 and as a 7" 33, 1-669. The B side was the re-issued "This Is the Night." Neither of the songs charted. The subject of the song is a stroll down the street in Atlanta, Georgia of the same name. Sinatra originally intended Dinah Shore to sing the duet with him. When Shore declined, Clooney was asked. The song was recorded on April 8, 1950. The song features spoken asides by Sinatra and Clooney. Rosemary Clooney asks: "Say, Frank, you wanna take a walk?" Frank Sinatra replies: "Sure, sweetie, just pick a street." He noted how there were no peach trees on the ...
We, Too, Have a Job to Do
... is a painting by American illustrator Norman Rockwell that depicts a Boy Scout in full uniform standing in front of a waving American flag. It was originally created by Rockwell in 1942 for the 1944 Brown & Bigelow Boy Scout Calendar. The model, Bob Hamilton, won a contest to be in the painting and personally delivered a print to the Vice President of the United States at the time, Henry A. Wallace. The painting was created to encourage Scouts to participate in the war effort during World War II. The name of the painting, We, Too, Have a Job to Do, comes from a slogan that the Boy Scouts of America used in 1942 to rally scouts to support the troops by collecting metal and planting victory gardens. The model, Bob Hamilton, won a contest with his local council in Albany, New York, to be depicted in the painting. He traveled to Rockwell's studio in Arlington, Vermont, to model for Rockwell. Since Hamilton was a scout, the uniform shown in the painting was his, unlike some ...
2021 Akkar explosion
At least 33[failed verification] people were killed by a fuel tanker explosion in Tleil, Akkar District, Lebanon on 15 August 2021. The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and fuel has been in short supply. The survivors were evacuated by the Lebanese Red Cross. An investigation is underway. The fuel tanker had been confiscated by the Lebanese Armed Forces from black marketeers, the fuel was then distributed/taken by the locals. The son of the man whose land the fuel tanker was located on, was later arrested, accused of deliberately causing the explosion. Agencies (2021-08-15). "At least 20 killed and 79 injured in fuel tank explosion in Lebanon". the Guardian. Retrieved 2021-08-15. "Lebanon fuel explosion kills 22 and injures dozens more". The Independent. 2021-08-15. Archived from the original on 2021-08-15. Retrieved 2021-08-15. "Lebanon: At least 20 dead and dozens injured after fuel tank explodes as ...
Straubing Tigers
The Straubing Tigers are a professional men's ice hockey team, based in Straubing, Germany, that competes in the Deutsche Eishockey Liga. Straubing plays its home games at the Eisstadion am Pulverturm, which has a capacity of 5,800 spectators. Promoted to the DEL in 2006, and operating with one of the league's smallest budgets, the team could finish no better than twelfth before the 2011-12 DEL season, when it reached the semi-finals of the playoffs. Their greatest success so far is the qualification for the season 2020-21 of the Champions Hockey League. In 1941, the then 14-year-old Max Pielmaier and his friends Max Pellkofer and Harry Poiger founded the first hockey team in Straubing. The first official game took place on the first of February 1942 in Hof and was lost by a score of 0:1. In the following year there were several games against other Bavarian teams. The game against Landshut on 31 January. 1943 was the last game during the second World War, because the young players also had to ...
Leina, Saare County
Leina is a village in Saaremaa Parish, Saare County in western Estonia. Before the administrative reform in 2017, the village was in Pihtla Parish. "Lisa. Asustusüksuste nimistu" (PDF). haldusreform.fin.ee (in Estonian). Rahandusministeerium. Retrieved 5 December 2017. "Saaremaa külad endiste valdade piires". www.saaremaa.ee (in Estonian). Archived from the original on 3 December 2017. Retrieved 5 December 2017. Coordinates: 58°17′10″N 22°46′26″E / 58.28611°N 22.77389°E / 58.28611; 22.77389 v t e (CS1 Estonian-language sources (et), Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Saaremaa Parish, Coordinates on Wikidata, Villages in Saare County, All stub articles, Saare County geography stubs ...
Sestiere
A sestiere (plural: sestieri) is a subdivision of certain Italian towns and cities. The word is from sesto ('sixth'), so it is thus used only for towns divided into six districts. The best-known example is the sestieri of Venice, but Ascoli Piceno, Genoa, Milan and Rapallo, for example, were also divided into sestieri. The medieval Lordship of Negroponte, on the island of Euboea, was also at times divided into six districts, each with a separate ruler, through the arbitration of Venice, which were known as sestieri. The island of Crete, a Venetian colony (the "Kingdom of Candia") from the Fourth Crusade, was also divided into six parts, named after the sestieri of Venice herself, while the capital Candia retained the status of a comune of Venice. The island of Burano north of Venice is also subdivided into sestieri. A variation of the word is occasionally found: the comune of Leonessa, for example, is divided into sesti or sixths. Other Italian towns with fewer than six official districts are ...
Island Image
The Island Image is a Chesapeake Bay log canoe, built in 1885 at Elliot's Island, Maryland, by Herman Jones and Isaac Moore. She is 29'-8½" long with a beam of 5-10¼", and has a straight, raking stem and a sharp stern. It is privately owned, and races under No. 17. She one of the last 22 surviving traditional Chesapeake Bay racing log canoes that carry on a tradition of racing on the Eastern Shore of Maryland that has existed since the 1840s. She is located at Chestertown, Kent County, Maryland. She was listed on the National Register of Historic Places in 1985. "National Register Information System". National Register of Historic Places. National Park Service. April 15, 2008. "Maryland Historical Trust". ISLAND IMAGE (log canoe). Maryland Historical Trust. 2008-06-14. "Island Image #17 , CBLCSA". Island Image. Chesapeake Bay Log Sailing Canoe Association. 2010-07-24. Archived from the original on 2011-07-08. Retrieved 2010-07-29. ISLAND IMAGE (log canoe), Kent County, including photo in 1984, ...
Bord Khun Rural District
... (Persian: دهستان بردخون) is a rural district (dehestan) in the Bord Khun District of Deyr County, Bushehr Province, Iran. At the 2006 census, its population was 1,115, in 234 families. The rural district has 14 villages. "Census of the Islamic Republic of Iran, 1385 (2006)" (Excel). Statistical Center of Iran. Archived from the original on 2011-11-11. Coordinates: 27°58′N 51°32′E / 27.967°N 51.533°E / 27.967; 51.533 v t e (Articles with short description, Short description matches Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Articles containing Persian-language text, Coordinates on Wikidata, Rural Districts of Bushehr Province, Deyr County, All stub articles, Deyr County geography stubs ...
Human CX3CL1/Fractalkine Chemokine Domain Antibody MAB3652-100: R&D Systems
View Human CX3CL1/Fractalkine Chemokine Domain Antibody (MAB3652-100) datasheet. ... Background: CX3CL1/Fractalkine. CX3CL1, also known as Fractalkine, is a type I membrane protein in which a chemokine domain ... ABCD-3; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; CXC3; CXC3C; FKN; Fractalkine; ... Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Human CX3CL1/Fractalkine Antibody. Recombinant Human CX3CL1/ ...
Chemokine CX3CL1 | Scholars@Duke
Chemokine CX3CL1 * Subject Areas on Research. * A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection ... The chemokine CX3CL1 regulates NK cell activity in vivo. * The homozygous CX3CR1-M280 mutation impairs human monocyte survival. ... Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. * Enrichment of endogenous fractalkine and ... The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with ...
The CX3CL1-CX3CR1 chemokine axis can contribute to... (ID 889446) - BioProject - NCBI
The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and bloc... The CX3CL1-CX3CR1 chemokine axis can ... The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody ... The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody ... The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody ...
CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases
CX3CL1, a chemokine finely tuned to adhesion: critical roles of the stalk glycosylation and the membrane domain | Biology Open ...
CX3CL1-EYFP w/o the cytosolic domain (w/o cyto CX3CL1), or CX3CL1-EYFP w/o the chemokine domain (w/o CD CX3CL1) mutants. The ... A) Diffusion rate assessed by FRAP in COS7 cells of native CX3CL1-EYFP or CX3CL1-EYFP lacking its chemokine domain (named "w/o ... A) Diffusion rate assessed by FRAP in COS7 cells of native CX3CL1-EYFP or CX3CL1-EYFP lacking its chemokine domain (named "w/o ... To generate the CX3CL1 without the cytosolic domain from CX3CL1 (w/o cyto CX3CL1), we used 5′- ...
Mediterranean Spotted Fever (Boutonneuse Fever): Background, Pathophysiology, Etiology
Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells. Its peak of expression on day 3 of infection ... Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. J Infect. 2009 ... Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group. Virchows ...
High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo - PubMed
Lipid-free apoA-I and rHDL reduce the expression of chemokines and chemokine receptors in vivo and in vitro via modulation of ... Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II. Rius C, ... High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo Christina A Bursill 1 , Maria L ... High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo Christina A Bursill et al. ...
Publication Detail
Biomarkers Search
negative regulation of tumor necrosis factor production - Ontology Report - Rat Genome Database
MeSH Browser
Chemokines [D12.644.276.374.200] * Chemokines, CX3C [D12.644.276.374.200.130] * Chemokine CX3CL1 [D12.644.276.374.200.130.500] ... Chemokines [D12.776.467.374.200] * Chemokines, CX3C [D12.776.467.374.200.130] * Chemokine CX3CL1 [D12.776.467.374.200.130.500] ... Chemokines [D23.529.374.200] * Chemokines, CX3C [D23.529.374.200.130] * Chemokine CX3CL1 [D23.529.374.200.130.500] ... Chemokines [D23.125.300] * Chemokines, CX3C [D23.125.300.130] * Chemokine CX3CL1 [D23.125.300.130.500] ...
APC/Fire™ 750 anti-human CX3CR1 Antibody, CX3CR1, 2A9-1
CX3CL1 (known also as fractalkine and neurotactin) is the ligand of CX3CR1. CX3CL1 ... CX3CR1 is a G-protein-coupled seven-transmembrane chemokine receptor, also called GPR13 or V28. It is expressed on NK cells, T ... CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. CX3CL1 is expressed by ... V28, GPR13, Chemokine C-X3-C receptor 1 Isotype Rat IgG2b, κ Ave. Rating Submit a Review Product Citations publications Human ...
Chronic Lung Allograft Dysfunction: A Systematic Review of M... : Transplantation
... activated endothelial cells express on their surface the chemokine CX3CL1 or fractalkine,78 which interact with the chemokine ... Lung biopsy profiling,187 BAL composition, neutrophilia,66,188,189 level of Treg cell,123,124 cytokines, chemokines,189 or MMP ... IL-15 alters expression and function of the chemokine receptor CX3CR1 in human NK cells. Cell Immunol. 2004;230:99-108.. * ... Upregulation of chemokines in bronchoalveolar lavage fluid as a predictive marker of post-transplant airway obliteration. J ...
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta,...
CCL2 C-C motif chemokine ligand 2 [Homo sapiens (human)] - Gene - NCBI
C-C motif chemokine ligand 2 (human). Find diseases associated with this biological target and compounds tested against it in ... Upregulation of the human proteins CCL2, CX3CL1, IL-1beta, and CXCL10 by HIV-1 gp120 involves CB2 receptor in mesencephalic ... C-C motif chemokine 2. Names. chemokine (C-C motif) ligand 2. monocyte chemoattractant protein-1. monocyte chemotactic and ... The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis. Title: The chemokine monocyte ...
IJMS | Free Full-Text | Brain RNA-Seq Profiling of the Mucopolysaccharidosis Type II Mouse Model
In fact, this infiltration may be dependent on Ccl3 (chemokine (C-C motif) ligand 3), as deletion of this chemokine results in ... Cx3cl1 and Ccl21b are up-regulated in both tissues, while Ccl3, Ccl5, Ccl6 and Ccl8 are up-regulated in Cx and down-regulated ... such as pro-inflammatory cytokines and chemokines, are differentially expressed in Ids-ko brain (Figure 10a,b and in Table S6h ...
mediaTUM - Media and Publication Server
BACKGROUND: The membrane-bound chemokine fractalkine (CX3CL1) is expressed on various cell types such as activated endothelial ... BACKGROUND: The membrane-bound chemokine fractalkine (CX3CL1) is expressed on various cell types such as activated endothelial ... Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role ... which suggests that the CX3CL1-CX3CR1 axis is critically involved in leukocyte adhesion to inflamed endothelial cells under ...
MeSH Browser
Chemokines [D12.644.276.374.200] * Chemokines, CX3C [D12.644.276.374.200.130] * Chemokine CX3CL1 [D12.644.276.374.200.130.500] ... Chemokines [D12.776.467.374.200] * Chemokines, CX3C [D12.776.467.374.200.130] * Chemokine CX3CL1 [D12.776.467.374.200.130.500] ... Chemokines [D23.529.374.200] * Chemokines, CX3C [D23.529.374.200.130] * Chemokine CX3CL1 [D23.529.374.200.130.500] ... Chemokines [D23.125.300] * Chemokines, CX3C [D23.125.300.130] * Chemokine CX3CL1 [D23.125.300.130.500] ...
VEGF Neutralization Plus CTLA-4 Blockade Alters Soluble and Cellular Factors Associated with Enhancing Lymphocyte Infiltration...
The levels of 39 cytokines and chemokines (EGF, CCL11/Eotaxin, FGF2, FLT3LG/Flt-3L, CX3CL1/Fractalkine, GM-CSF, CXCL1/GRO, CSF3 ... Altered circulating cytokine and chemokine concentrations. Cytokines and chemokines can induce adhesion molecule expression and ... of the patients had increases in all six cytokines/chemokines in response to Ipi-Bev. For cytokines/chemokines with ... Serum cytokine/chemokine expression and irAEs. In the Ipi-Bev-treated patients, severe (grade 3 or higher) irAEs include rash, ...
Búsqueda | BVS CLAP/SMR-OPS/OMS
Chemokines
Cx3cl1. fractalkine O35188. T-lymphocytes and monocytes. Cxcl5. C-X-C motif chemokine 5 P50228. neutrophils. ... C-C motif chemokine 17 F6R5P4. memory T-helper cells. Ccl19. C-C motif chemokine 19 O70460. CD4 T-cells, CD8 T-cells, resting B ... C-C motif chemokine 27 Q9Z1X0. skin-associated memory T-lymphocytes. Ccl28. C-C motif chemokine 28 Q9JIL2. resting CD4, CD8 T- ... C-C motif chemokine 21a P84444. thymocytes and activated T-cells. Ccl21b. C-C motif chemokine 21b P86792. thymocytes and ...
DeCS
Chemokine CX3CL1 Entry term(s). CX3CL1 Chemokine CX3CL1, Chemokine Chemokine (C-X3-C Motif) Ligand 1 Chemokine, CX3CL1 ... Chimiokine CX3CL1 Entry term(s):. CX3CL1 Chemokine. CX3CL1, Chemokine. Chemokine (C-X3-C Motif) Ligand 1. Chemokine, CX3CL1. ... Chemokine CX3CL1 - Preferred Concept UI. M0272052. Scope note. A CX3C chemokine that is a transmembrane protein found on the ... 2008; CHEMOKINE (C-X3-C MOTIF) LIGNAND 1 (now CHEMOKINE CX2CL1) was indexed under CHEMOKINES, CX3C 2002-2007, under CHEMOKINES ...
Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in...
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A. 2000;97(14): ... CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. Pharmacol Ther. 2022;231:107989. ... 5 J, K). CX3CR1 (C-X3-C motif chemokine receptor 1), expressed by both microglia and neurons, mediates microglial adhesion, ...
Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to ...
... while primary blast instigated prominent systemic cytokine/chemokine, Orexin A, and Neuropilin-2 release, particularly when ... while primary blast instigated prominent systemic cytokine/chemokine, Orexin A, and Neuropilin-2 release, particularly when ... while primary blast instigated prominent systemic cytokine/chemokine, Orexin A, and Neuropilin-2 release, particularly when ... while primary blast instigated prominent systemic cytokine/chemokine, Orexin A, and Neuropilin-2 release, particularly when ...
Pesquisa | Prevenção e Controle de Câncer
C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several ... The present study confirmed that CX3CL1 increased cell movement, migration and invasion. The CX3CL1-induced cell motility is ... The CX3CL1-CX3CR1 axis activates promoted PLCß/PKCα/c-Src phosphorylation. Furthermore, CX3CL1 enhanced activator protein-1 (AP ... CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells. ...
Pharos : Target Details - CX3CR1
CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as ... Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded ... Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions ( ... Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded ...
increased respiratory quotient - Ontology Report - Rat Genome Database
Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice | Genes &...
The CX3CL1 gene encodes for a cell-bound CXC chemokine involved in the activation and adhesion of leukocytes [52, 53]. Once ... chemokines (CX3CL1; FC = 0.78), cytokines (TNFRSF14; FC = 0.82) and complement components (C3; FC = 0.80) as well as cell ... Bone-Larson CL, Simpson KJ, Colletti LM, Lukacs NW, Chen SC, Lira S, Kunkel SL, Hogaboam CM (2000) The role of chemokines in ... Simpson KJ, Henderson NC, Bone-Larson CL, Lukacs NW, Hogaboam CM, Kunkel SL (2003) Chemokines in the pathogenesis of liver ...
Delivery of exogenous proteins by mesenchymal stem cells attenuates early memory deficits in a murine model of Alzheimer's...
Chemokine C-X3-C Motif Ligand 1 (CX3CL1). Growth Associated Protein 43 (GAP43) ... Transplantation of MSCs carrying CX3CL1 and Wnt3a (CX3CL1-Wnt3a-MSC) significantly attenuated the learning and memory ... Transplantation of CX3CL1-Wnt3a-MSC also regulated phosphoinositide 3-kinase/activated protein kinase B (PI3K/AKT) signaling to ... The improvement of neurobehavioral functions in APP/PS1 mice treated with CX3CL1-Wnt3a-MSC was related to the inhibition of ...
Fractalkine13
- Detects human CX3CL1/Fractalkine in ELISAs. (rndsystems.com)
- Measured by its ability to neutralize CX3CL1/Fractalkine-induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with mouse CX3CR1. (rndsystems.com)
- The Neutralization Dose (ND 50 ) is typically 1-5 µg/mL in the presence of 100 ng/mL Recombinant Human CX3CL1/Fractalkine. (rndsystems.com)
- Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Human CX3CL1/Fractalkine Antibody. (rndsystems.com)
- Recombinant Human CX3CL1/Fractalkine (Catalog # 365-FR ) chemoattracts the BaF3 mouse pro-B cell line transfected with mouse CX3CR1 in a dose-dependent manner (orange line). (rndsystems.com)
- Chemotaxis elicited by Recombinant Human CX3CL1/Fractalkine (100 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human CX3CL1/Fractalkine Chemokine Domain Monoclonal Antibody (Catalog # MAB3652). (rndsystems.com)
- CX3CL1, also known as Fractalkine, is a type I membrane protein in which a chemokine domain possessing a unique C-X3-C cysteine motif is tethered on a long mucin-like stalk. (rndsystems.com)
- CX3CL1 (known also as fractalkine and neurotactin) is the ligand of CX3CR1. (biolegend.com)
- Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets. (tum.de)
- BACKGROUND: The membrane-bound chemokine fractalkine (CX3CL1) is expressed on various cell types such as activated endothelial cells and has been implicated in the inflammatory process of atherosclerosis. (tum.de)
- With the use of intravital video-fluorescence microscopy we demonstrate that inhibition of fractalkine signaling attenuates leukocyte adhesion to the atherosclerotic carotid artery of apolipoprotein E-deficient mice, which suggests that the CX3CL1-CX3CR1 axis is critically involved in leukocyte adhesion to inflamed endothelial cells under high shear forces both in vitro and in vivo. (tum.de)
- Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. (nih.gov)
- The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). (nih.gov)
CCL25
- Both CCL2 and CX3CL1 concentrations were increased in plasma and lungs of ILD patients. (nih.gov)
- To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX(3)CL1) and chemokine receptor (CCR2 and CX(3)CR1) expression, a mechanism for the atheroprotective properties of HDLs. (nih.gov)
- DNA damage) in the neuronal retina, which is accompanied by a low-grade chronic inflammation, para-inflammation, characterized by upregulated expression of chemokines (CCL2, CXCL12, and CX3CL1) and complement components (C4 and CFH), and microglial activation. (qub.ac.uk)
- The upregulation of chemokines CCL2 and CXCL12 and complement C4 lasted for more than 160 days, whereas the expression of CX3CL1 and CFH was upregulated for 2 weeks. (qub.ac.uk)
- The recruitment of BM-derived myeloid cells is a part of the para-inflammatory response and is CCL2 but not CX3CL1 dependent. (qub.ac.uk)
Cytokine2
- The most significant and persistent changes in neuro-glial markers were found after composite blast, while primary blast instigated prominent systemic cytokine/chemokine, Orexin A, and Neuropilin-2 release, particularly when primary blast impacted rats with unprotected body. (johnshopkins.edu)
- We observed that engrafted MSCs carrying exogenous (C-X3-C motif) ligand 1 (CX3CL1) alone reduced the production of the inflammatory cytokine TNF-ɑ and improved synapse-related protein expression but not cognitive function. (nih.gov)
Receptor3
- 2. S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. (nih.gov)
- CX3CR1 is a G-protein-coupled seven-transmembrane chemokine receptor, also called GPR13 or V28. (biolegend.com)
- Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal. (biolegend.com)
CX3CR13
- The CX3CL1-CX3CR1 chemokine axis can contribute to. (nih.gov)
- The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances responses to anti-PD-1 immunotherapy. (nih.gov)
- The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and bloc. (nih.gov)
Receptors2
- Does staining at room temperature or even at 37°C help for checking chemokine receptors expression? (biolegend.com)
- It binds to chemokine receptors CCR2 and CCR4. (nih.gov)
Endothelial Cells2
- CX3CL1 is expressed by activated-endothelial cells, neurons, and astrocytes. (biolegend.com)
- METHODS AND RESULTS: With the use of immunofluorescence and laminar flow assays, the present study shows that human umbilical vein endothelial cells stimulated with tumor necrosis factor-alpha and interferon-gamma abundantly express CX3CL1 and promote substantial leukocyte accumulation under arterial flow conditions. (tum.de)
CX3C3
- A CX3C chemokine that is a transmembrane protein found on the surface of cells. (nih.gov)
- CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. (biolegend.com)
- Quimioquina CX3C que es una proteína transmembrana que se ubica en la superficie de las células. (bvsalud.org)
Cytokines and chemokines1
- Human Qbeads Inflammation Panel Kit allows the measurement of seven human cytokines and chemokines from either serum or in vitro samples. (sartorius.com)
Neuroinflammation1
- Chemokine Dysregulation and Neuroinflammation in Schizophrenia: A Systematic Review. (cdc.gov)
Binds1
- binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). (nih.gov)
Protein1
- Transplantation of CX3CL1-Wnt3a-MSC also regulated phosphoinositide 3-kinase/activated protein kinase B (PI3K/AKT) signaling to inhibit the activity of glycogen synthase kinase 3 beta (GSK3b). (nih.gov)
Vitro1
- The Chemokine CX3CL1 Improves Trastuzumab Efficacy in HER2 Low-Expressing Cancer In Vitro and In Vivo . (bvsalud.org)
Soluble2
- The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. (nih.gov)
- La forma soluble de la quimioquina CX3CL1 puede liberarse de la superficie celular mediante proteólisis y actúa como quimioatrayente involucrado en la extravasación de leucocitos en los tejidos inflamados. (bvsalud.org)
Microglial1
- The improvement of neurobehavioral functions in APP/PS1 mice treated with CX3CL1-Wnt3a-MSC was related to the inhibition of microglial neurotoxicity and promotion of hippocampal neurogenesis. (nih.gov)
Inflammatory2
- Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. (nih.gov)
- The cytokines/chemokines included are implicated in inflammatory responses to disease states including autoimmune diseases, chronic inflammation, and infections, including viral infections such as COVID-19. (sartorius.com)
Cysteine1
- This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. (nih.gov)
Recruitment1
- IL-13 also induces secretion of chemokines that are required for recruitment of allergic effector cells to the lung. (wikidoc.org)
Human1
- In sandwich immunoassays, less than 10% cross-reactivity with recombinant mouse CXCL6 and less than 0.2% cross-reactivity with recombinant human (rh) CXCL6, rhCXCL9, and recombinant rat CX3CL1 is observed. (rndsystems.com)
English1
- Online at: https://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-articulo-black-spot-or-tache-noire-S2387020618302328. (medscape.com)
Memory1
- Transplantation of MSCs carrying CX3CL1 and Wnt3a (CX3CL1-Wnt3a-MSC) significantly attenuated the learning and memory impairment when compared with a control group. (nih.gov)
Surface1
- The model he proposed was that 1) DC enters lymphatics thanks to a chemokine gradient (including CCL21 and CX3CL1) and 2) they synthesize a surface hyaluronan glycocalyx that acts as adhesin. (cfcd.fr)
Fractalkine4
- 7. Characterisation of fractalkine/CX3CL1 and fractalkine receptor (CX3CR1) expression in abdominal aortic aneurysm disease. (nih.gov)
- 12. The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. (nih.gov)
- 16. Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1). (nih.gov)
- Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. (nih.gov)
Receptor5
- CX3CL1 and its receptor CX3CR1 have been emphasized in atherosclerosis recently. (nih.gov)
- In this study we investigated the role of the chemokines CX3CL1 and their receptor CX3CR1 in atherogenesis and identified whether the genetic variations in CX3CL1 and CX3CR1 impacted the atherosclerosis process in coronary artery disease (CAD) or not. (nih.gov)
- 11. IL-15 alters expression and function of the chemokine receptor CX3CR1 in human NK cells. (nih.gov)
- Receptor de la QUIMIOCINA CX3CL1 expresado en los linfocitos, neuronas y NEUROGLÍA. (bvsalud.org)
- Receptor for CHEMOKINE CX3CL1 expressed by lymphocytes, neurons, and GLIAL CELLS. (bvsalud.org)
MOTIF1
- We observed that engrafted MSCs carrying exogenous (C-X3-C motif) ligand 1 (CX3CL1) alone reduced the production of the inflammatory cytokine TNF-ɑ and improved synapse-related protein expression but not cognitive function. (nih.gov)
Mediates1
- binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). (nih.gov)
Role1
- In next part of the review, various chemokines with their specific role in altering immune response to combat various diseases especially cancers will be discussed. (medscape.com)
Cells1
- 9. The R132H mutation in IDH1 promotes the recruitment of NK cells through CX3CL1/CX3CR1 chemotaxis and is correlated with a better prognosis in gliomas. (nih.gov)
Expression3
- CX3CL1/CX3CR1 expression in coronary and carotid artery specimens were analysed by immunohistochemistry. (nih.gov)
- Immunohistochemical staining of tissue from CAD patients showed increased CX3CL1/CX3CR1 expression in atherosclerotic coronary and carotid artery plaques compared with normal arteries. (nih.gov)
- CX3CL1/CX3CR1 expression was correlated with the severity of the atherosclerosis lesion. (nih.gov)
Cell2
- 5. Novel cooperation between CX3CL1 and CCL26 inducing NK cell chemotaxis via CX3CR1: a possible mechanism for NK cell infiltration of the allergic nasal tissue. (nih.gov)
- The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. (nih.gov)
Functions1
- The improvement of neurobehavioral functions in APP/PS1 mice treated with CX3CL1-Wnt3a-MSC was related to the inhibition of microglial neurotoxicity and promotion of hippocampal neurogenesis. (nih.gov)
