A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
A CC-type chemokine with specificity for CCR4 RECEPTORS. It has activity towards TH2 CELLS and TC2 CELLS.
A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.
A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.
A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES.
A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. It has specificity for CCR8 RECEPTORS.
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES; and a variety of other immune cells. This chemokine is encoded by multiple genes.
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
CCR receptors with specificity for CHEMOKINE CCL27. They may play a specialized role in the cutaneous homing of LYMPHOCYTES.
A CC chemokine with specificity for CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES and a variety of other immune cells. This chemokine is encoded by multiple genes.
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
A CXC chemokine that is induced by GAMMA-INTERFERON and is chemotactic for MONOCYTES and T-LYMPHOCYTES. It has specificity for the CXCR3 RECEPTOR.
A monocyte chemoattractant protein that attracts MONOCYTES; LYMPHOCYTES; BASOPHILS; and EOSINOPHILS. Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS.
Chemokine receptors that are specific for CC CHEMOKINES.
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
A CC-type chemokine with specificity for CCR3 RECEPTORS. It is a chemoattractant for EOSINOPHILS.
CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
CCR receptors with specificity for CHEMOKINE CCL1. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and MACROPHAGES.
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.
CCR receptors with specificity for CHEMOKINE CCL17 and CHEMOKINE CCL22. They are expressed at high levels in T-LYMPHOCYTES; MAST CELLS; DENDRITIC CELLS; and NK CELLS.
Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.
A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell surface by proteolysis and act as a chemoattractant that may be involved in the extravasation of leukocytes into inflamed tissues. The membrane form of the protein may also play a role in cell adhesion.
Heparin-binding proteins that exhibit a number of inflammatory and immunoregulatory activities. Originally identified as secretory products of MACROPHAGES, these chemokines are produced by a variety of cell types including NEUTROPHILS; FIBROBLASTS; and EPITHELIAL CELLS. They likely play a significant role in respiratory tract defenses.
CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.
CCR receptors with specificity for CHEMOKINE CCL11 and a variety of other CC CHEMOKINES. They are expressed at high levels in T-LYMPHOCYTES; EOSINOPHILS; BASOPHILS; and MAST CELLS.
An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
A CXC chemokine that is chemotactic for B-LYMPHOCYTES. It has specificity for CXCR5 RECEPTORS.
CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.
A CXC chemokine that is induced by GAMMA-INTERFERON. It is a chemotactic factor for activated T-LYMPHOCYTES and has specificity for the CXCR3 RECEPTOR.
The movement of cells or organisms toward or away from a substance in response to its concentration gradient.
A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A CXC chemokine that is predominantly expressed in EPITHELIAL CELLS. It has specificity for the CXCR2 RECEPTORS and is involved in the recruitment and activation of NEUTROPHILS.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Established cell cultures that have the potential to propagate indefinitely.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
CCR receptors with specificity for CHEMOKINE CCL20. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and BASOPHILS.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Chemokine receptors that are specific for CXC CHEMOKINES.
A cell line derived from cultured tumor cells.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Group of chemokines with the first two cysteines separated by three amino acids. CX3C chemokines are chemotactic for natural killer cells, monocytes, and activated T-cells.
CXCR receptors isolated initially from BURKITT LYMPHOMA cells. CXCR5 receptors are expressed on mature, recirculating B-LYMPHOCYTES and are specific for CHEMOKINE CXCL13.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Soluble mediators of the immune response that are neither antibodies nor complement. They are produced largely, but not exclusively, by monocytes and macrophages.
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. Included are CD4 ANTIGENS, found on T4 lymphocytes, and monocytes/macrophages, which bind to the HIV ENVELOPE PROTEIN GP120.
A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.
Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Adherence of cells to surfaces or to other cells.
Proteins prepared by recombinant DNA technology.
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Elements of limited time intervals, contributing to particular results or situations.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Unbroken cellular lining (intima) of the lymph vessels (e.g., the high endothelial lymphatic venules). It is more permeable than vascular endothelium, lacking selective absorption and functioning mainly to remove plasma proteins that have filtered through the capillaries into the tissue spaces.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.

Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa. (1/151)

BACKGROUND: The beta chemokine monocyte chemotactic protein 3 (MCP-3) has chemoattractant and activating capabilities in monocytes, lymphocytes, eosinophils, and basophils. AIMS: To investigate MCP-3 expression in inflammatory conditions of the human intestinal mucosa. PATIENTS: Forty five colon biopsy specimens from 18 patients with inflammatory bowel disease (IBD; 16 specimens from inflamed and 10 from non-inflamed areas) and 19 control patients were examined. METHODS: Immunohistochemical staining and reverse transcription polymerase chain reaction (RT-PCR) were used for MCP-3 detection in tissue sections. Intestinal epithelial cell lines (HT-29, Caco-2, T-84) were stimulated with interleukin (IL) 1beta, IL-6, and tumour necrosis factor alpha (TNF-alpha) and examined for MCP-3 protein and mRNA expression using immunocytochemistry and RT-PCR, respectively. RESULTS: In tissue sections, MCP-3 protein was detected predominantly in epithelial cells, both in patients with IBD and in controls. MCP-3 staining was particularly pronounced at sites of active mucosal inflammation. The intensity of MCP-3 staining was positively correlated with the extent of epithelial destruction. In intestinal epithelial cell lines, MCP-3 mRNA was expressed, whereas MCP-3 protein was not consistently detected. CONCLUSIONS: Our data show that MCP-3 protein is present in normal and inflamed intestinal tissue. MCP-3 production is substantially enhanced in areas of active inflammation, suggesting an immunoregulatory role of MCP-3 in intestinal inflammation.  (+info)

Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis. (2/151)

Chemokines are thought to be important for the recruitment of granulocytes and mononuclear cells and thus for the maintenance of inflammation in ulcerative colitis (UC). We have studied the expression of interferon-gamma inducible protein-10 (IP-10), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP)-1, MCP-3, and macrophage inflammatory protein (MIP)-1alpha in UC patients and control individuals to assess the role of these chemokines in disease progression. Colonic biopsies were taken endoscopically from patients and controls, frozen immediately and subsequently stained for IP-10, IL-8, MCP-1, MCP-3, and MIP-1alpha in serial sections. Cells infiltrating the lamina propria but not epithelial cells express the analyzed chemokines. They were differentiated and counted, and chemokine-expressing cells were quantified by image analysis. The percentage of cells expressing IP-10, IL-8, MCP-1, and MCP-3 was significantly enhanced in all UC samples as compared to controls. Expression in the controls was borderline, except for IP-10. No expression of MIP-1alpha was found in controls and UC. IP-10 was also markedly expressed in the mucosa of control biopsies and therefore could have a role in activated T lymphocytes' recruitment into the healthy mucosa.  (+info)

CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. (3/151)

CCR5 was first characterized as a receptor for MIP-1alpha, MIP-1beta, and RANTES, and was rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 strains and simian immunodeficiency virus (SIV). Chemokines constitute a rapidly growing family of proteins and receptor-chemokine interactions are known to be promiscuous and redundant. We have therefore tested whether other CC-chemokines could bind to and activate CCR5. All CC-chemokines currently available were tested for their ability to compete with [(125)I]-MIP-1beta binding on a stable cell line expressing recombinant CCR5, and/or to induce a functional response in these cells. We found that in addition to MIP-1beta, MIP-1alpha, and RANTES, five other CC-chemokines could compete for [(125)I]-MIP-1beta binding: MCP-2, MCP-3, MCP-4, MCP-1, and eotaxin binding was characterized by IC(50) values of 0.22, 2.14, 5.89, 29.9, and 21.7 nmol/L, respectively. Among these ligands, MCP-3 had the remarkable property of binding CCR5 with high affinity without eliciting a functional response, MCP-3 could also inhibit the activation of CCR5 by MIP-1beta and may therefore be considered as a natural antagonist for CCR5. It was unable to induce significant endocytosis of the receptor. Chemokines that could compete with high affinity for MIP-1beta binding could also compete for monomeric gp120 binding, although with variable potencies; maximal gp120 binding inhibition was 80% for MCP-2, but only 30% for MIP-1beta. MCP-3 could compete efficiently for gp120 binding but was, however, found to be a weak inhibitor of HIV infection, probably as a consequence of its inability to downregulate the receptor.  (+info)

C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). (4/151)

The relationship of expression of the C-C chemokines eotaxin, eotaxin 2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4 to the kinetics of infiltrating eosinophils, basophils, and other inflammatory cells was examined in allergen-induced, late-phase allergic reactions in the skin of human atopic subjects. EG2+ eosinophils peaked at 6 h and correlated significantly with eotaxin mRNA and protein, whereas declining eosinophils at 24 h correlated significantly with eotaxin-2 and MCP-4 mRNA. In contrast, no significant correlations were observed between BB1+ basophil infiltrates, which peaked at 24 h, and expression of eotaxin, eotaxin-2, RANTES, MCP-3, and MCP-4 or elastase+ neutrophils (6-h peak), CD3+ and CD4+ T cells (24 h), and CD68+ macrophages (72 h). Furthermore, 83% of eosinophils, 40% of basophils, and 1% of CD3+ cells expressed the eotaxin receptor CCR3, while eotaxin protein was expressed by 43% of macrophages, 81% of endothelial cells, and 6% of T cells (6%). These data suggest that 1) eotaxin has a role in the early 6-h recruitment of eosinophils, while eotaxin-2 and MCP-4 appear to be involved in later 24-h infiltration of these CCR3+ cells; 2) different mechanisms may guide the early vs late eosinophilia; and 3) other chemokines and receptors may be involved in basophil accumulation of allergic tissue reactions in human skin.  (+info)

Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells. (5/151)

Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present antigen. The molecular basis for the peculiar trafficking properties of DC is largely unknown. In this study, mouse DC were generated from CD34+ bone marrow precursors and cultured with granulocyte-macrophage-CSF and Flt3 ligand for 9 days. Chemokines active on immature DC include MIP1alpha, RANTES, MIP1beta, MCP-1, MCP-3, and the constitutively expressed SDF1, MDC, and ELC. TNF-alpha-induced DC maturation caused reduction of migration to inducible chemokines (MIP1alpha, RANTES, MIP1beta, MCP-1, and MCP-3) and increased migration to SDF1, MDC, and ELC. Similar results were obtained by CD40 ligation or culture in the presence of bacterial lipopolysaccharide. TNF-alpha down-regulated CC chemokine receptor (CCR)1, CCR2, and CCR5 and up-regulated CCR7 mRNA levels, in agreement with functional data. This study shows that selective responsiveness of mature and immature DC to inducible vs. constitutively produced chemokines can contribute to the regulated trafficking of DC.  (+info)

Sensitivity of human immunodeficiency virus infection to various alpha, beta and gamma chemokines. (6/151)

Examination of a large panel of chemokines indicates that in addition to RANTES, MIP-1alpha and MIP-1beta, the beta-chemokine MCP-2 and, to a lesser extent, the gamma-chemokine lymphotactin also show anti-human immunodeficiency virus (HIV) activity in cell culture. The amount of chemokine needed to suppress HIV replication by > or = 50% was generally greater (> or = 250 ng/ml) than that required for inhibition of virus infection by RANTES, MIP-1alpha and MIP-1beta. The beta-chemokine MCP-3 was found to enhance the replication of both non-syncytium-inducing (NSI) and syncytium-inducing (SI) viruses at high concentrations (0.5-5 microg/ml). In contrast to a previous report, macrophage-derived chemokine was not found to inhibit HIV replication of either NSI or SI viruses, but at low concentrations enhanced NSI virus replication. When small amounts of RANTES or MCP-2 were added together with high concentrations of non-inhibitory chemokines, the anti-HIV effects were countered. Information on chemokines that affect HIV infection could be useful for future therapeutic strategies.  (+info)

Expression of monocyte chemotactic protein-3 mRNA in rat vascular smooth muscle cells and in carotid artery after balloon angioplasty. (7/151)

Monocyte chemotactic protein-3 (MCP-3) is a CC chemokine that functions in chemoattraction and activation of monocytes, T lymphocytes, eosinophils, basophils, natural killer cells and dendritic cells. The activation of the target cells by MCP-3 is via specific chemokine receptors CCR2 and CCR3, of which CCR2 is shared with MCP-1. MCP-1 and CCR2 have been implicated in vascular diseases including atherosclerosis and restenosis, that are known to be involved in inflammation (accumulation of T lymphocytes and monocytes) and smooth muscle cell (SMC) activation (proliferation, migration and matrix deposition). To investigate a potential role of MCP-3 in vascular injury, the present work examined its mRNA expression in rat aortic SMCs stimulated with various inflammatory stimuli including LPS, TNF-alpha, IL-1beta, IFN-gamma and TGF-beta. A time- and concentration-dependant induction of MCP-3 mRNA in SMCs was observed by means of Northern analysis. A strikingly similar expression profile was observed for MCP-3 and MCP-1 mRNA in SMCs. Furthermore, MCP-3 mRNA expression was induced in rat carotid artery after balloon angioplasty. A significant induction in MCP-3 mRNA was observed in the carotid artery at 6 h (41-fold increase over control, P<0.001), 1 day (13-fold increase, P<0.001) and 3 days (6-fold increase, P<0.01) after balloon angioplasty as quantitated by reverse transcription and polymerase chain reaction. These data provide evidence for the cytokine-induced expression of MCP-3 in SMCs and in carotid artery after balloon angioplasty, suggesting a potential role of MCP-3 in the pathogenesis of restenosis and atherosclerosis.  (+info)

Selective suppression of IL-12 production by chemoattractants. (8/151)

We investigated the ability of chemoattractants to affect IL-12 production by human monocytes and dendritic cells. We found that pretreatment of monocytes with macrophage chemoattractant proteins (MCP-1 to -4), or C5a, but not stromal-derived factor-1, macrophage inflammatory protein-1alpha, RANTES, or eotaxin, inhibited IL-12 p70 production in response to stimulation with Staphylococcus aureus, Cowan strain 1 (SAC), and IFN-gamma. The production of TNF-alpha and IL-10, however, was minimally affected by any of the chemoattractants. The degree of inhibition of IL-12 p70 production by MCP-1 to -4 was donor dependent and was affected by the autocrine inhibitory effects of IL-10. In contrast, C5a profoundly suppressed IL-12 production in an IL-10-independent fashion. Neither TGF-beta1 nor PGE2 was important for the suppression of IL-12 by any of the chemoattractants tested. The accumulation of mRNA for both IL-12 p35 and p40 genes was inhibited by chemokine pretreatment. Interestingly, MCP-1 to -4 and C5a did not suppress IL-12 production by monocyte-derived dendritic cells (DC) stimulated with CD40 ligand and IFN-gamma or by SAC and IFN-gamma, suggesting that these factors may act at the site of inflammation to suppress IL-12 and IFN-gamma production rather than in the lymph node to affect T cell priming. Despite the inability of C5a to inhibit IL-12 production by DCs, the receptor for C5a (CD88) was expressed by these cells, and recombinant C5a induced a Ca2+ flux. Taken together, these results define a range of chemoattractant molecules with the ability to suppress IL-12 production by human monocytes and have broad implications for the regulation of immune responses in vivo.  (+info)

Purchase Rat monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit. It is produced in . High purity. Good price.
PAA087Si01, CCL2; GDCF2; HC11; HSMCR30; MCAF; MCP1; SCYA2; SMC-CF; Chemokine C-C-Motif Ligand 2; Monocyte Chemotactic And Activating Factor; Monocyte Secretory Protein JE | Products for research use only!
LAA087Si71, CCL2; GDCF2; HC11; HSMCR30; MCAF; MCP1; SCYA2; SMC-CF; Chemokine C-C-Motif Ligand 2; Monocyte Chemotactic And Activating Factor; Monocyte Secretory Protein JE | Products for research use only!
By Northern analysis, freshly isolated monocytes contained no detectable mRNA for monocyte chemotactic protein-1 (MCP-1). However, after 4 hours of incubation at 37 degrees C, MCP-1 mRNA was clearly induced in the monocytes and was found to be highly dependent and directly proportional to the monocyte density. The level of MCP-1 mRNA continued to increase, reaching a peak after 22 hours of incubation. After 3 days in culture, MCP-1 mRNA levels had declined substantially and after 8 days were undetectable in the monocytes/macrophages. The amount of MCP-1 protein secreted correlated with the density-dependent increase in MCP-1 message. We hypothesize that the migration of monocytes into inflammatory lesions may be amplified by the density and time-dependent induction of MCP-1. ...
Bachem offers H-5826 Monocyte Chemotactic Protein-1 (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
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Looking for online definition of Stimulated T-cell chemotactic protein 1 in the Medical Dictionary? Stimulated T-cell chemotactic protein 1 explanation free. What is Stimulated T-cell chemotactic protein 1? Meaning of Stimulated T-cell chemotactic protein 1 medical term. What does Stimulated T-cell chemotactic protein 1 mean?
Angiogenesis is a hallmark of malignant neoplasias, as the formation of new blood vessels is required for tumors to acquire oxygen and nutrients essential for their continued growth and metastasis. However, the signaling pathways leading to tumor vascularization are not fully understood. Here, using a transplantable mouse tumor model, we have demonstrated that endogenous IFN-β inhibits tumor angiogenesis through repression of genes encoding proangiogenic and homing factors in tumor-infiltrating neutrophils. We determined that IFN-β-deficient mice injected with B16F10 melanoma or MCA205 fibrosarcoma cells developed faster-growing tumors with better-developed blood vessels than did syngeneic control mice. These tumors displayed enhanced infiltration by CD11b+Gr1+ neutrophils expressing elevated levels of the genes encoding the proangiogenic factors VEGF and MMP9 and the homing receptor CXCR4. They also expressed higher levels of the transcription factors c-myc and STAT3, known regulators of ...
Stem cell transplantation has recently emerged as a promising tool for the treatment of AMI and ADSCs appear to be a suitable candidate for stem cell therapy. However, despite the improved cardiac function and reduced infarct size observed following injection of ADSCs, the clinical benefits and long-term outcomes remain under debate (27-29). The major obstacle in ADSC therapy is the washout of transplanted cells from the heart (30). The magnitude of cell washout may depend on the presence of cell traffcking and/or homing factors in transplanted cells and the heart. The SDF-1α/CXCR4 cascade has previously been identified as a key factor in the recruitment of stem cells to areas of injured tissue in multiple organ systems (31-33), which is fundamental in stem cell therapy following AMI (34). Briefly, on binding to CXCR4, SDF-1α induces the mobilization of calcium, decreases levels of cyclic AMP within the cells and activates several signaling pathways (35). Ultimately, SDF-1α-bound CXCR4 causes ...
BioMarker Inflammation. Elevated levels of MCP-1 is seen in diseases such as atherosclerosis, nephropathy, rheumatoid arthritis, multiple sclerosis and NASH.
Monocyte chemotactic protein-1 (MCP-1) also known as monocyte chemotactic and activating factor (MCAF) was identified based on its ability to chemoattract monocytes. Subsequently, MCP-1 has also been found to regulate adhesion molecule expression and cytokine production in monocytes. MCP-1 is identi
Monocyte Chemotactic Protein-3 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids.
Monocyte Chemotactic Protein-1 Human Recombinant also known as MCAF, produced in E.Coli, is a non-glycosylated, Polypeptide chain containing 76 amino acids.
Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1α, and MIP-1β, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains. ...
Mouse C-C Motif Chemokine 2 / Monocyte Chemoattractant Protein 1 (CCL2/MCP1) standard, for use in running standard curves in AlphaLISA no-wash detection assays.
1 x 96-well, includes coupled magnetic beads and detection antibodies for detecting human MCP-1 / CCL2, requires reagent kit C III (171-304090 for vacuum separation or 171-304090M for magnetic separation) and a vial of standards (171-DK0001)
1 x 96-well, includes coupled magnetic beads and detection antibodies for detecting human MCP-1 / CCL2, requires reagent kit C III (171-304090 for vacuum separation or 171-304090M for magnetic separation) and a vial of standards (171-DK0001)
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Morbidity and mortality attributable to hypertension are higher in black essential hypertensive (EH) compared with white EH patients, possibly related to differential effects on vascular injury and repair. Although circulating endothelial progenitor cells (EPCs) preserve endothelial integrity, inflammatory endothelial cells (IECs) detach from sites of injury and represent markers of vascular damage. We hypothesized that blood levels of IECs and inflammatory markers would be higher in black EH compared with white EH patients. Inferior vena cava and renal vein levels of CD34+/KDR+ (EPC) and VAP-1+ (IEC) cells were measured by fluorescence-activated cell sorting in white EH and black EH patients under fixed sodium intake and blockade of the renin-angiotensin system, and compared with systemic levels in normotensive control subjects (n=19 each). Renal vein and inferior vena cava levels of inflammatory cytokines and EPC homing factors were measured by Luminex. Blood pressure, serum creatinine, ...
Recruitment of macrophages to sites of cell death is critical for induction of an immunologic response. Calcium concentrations in extracellular fluids vary markedly, and are particularly high at sites of injury or infection. We hypothesized that extracellular calcium participates in modulating the immune response, perhaps acting via the seven-transmembrane calcium-sensing receptor (CaR) on mature monocytes/macrophages. We observed a dose-dependent increase in monocyte chemotaxis in response to extracellular calcium or the selective allosteric CaR activator NPS R-467. In contrast, monocytes derived from mice deficient in CaR lacked the normal chemotactic response to a calcium gradient. Notably, CaR activation of monocytes bearing the receptor synergistically augmented the transmigration response of monocytes to the chemokine MCP-1 in association with increased cell-surface expression of its cognate receptor, CCR2. Conversely, stimulation of monocytes with MCP-1 or SDF-1α reciprocally increased ...
MCP-1 (5); Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting. Bulk and Prepack available at Sigmaaldrich.com.
Monoclonal Anti-Monocyte Chemotactic Protein-2 antibody produced in mouse is suitable for indirect ELISA, western blot, neutralization
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Chemokine (C-C motif) ligand 8--also known as monocyte chemoattractant protein 2 (MCP-2), HC14, SCYA8, or SCYA10--is a protein encoded by the CCL8 gene. The precursor protein (109 amino acids) is cleaved to produce mature CCL8 (75 amino acids). CCL8 activates many different immune cells, including mast cells, eosinophils, and basophils (implicated in allergic responses), and monocytes, T cells, and NK cells (involved in the inflammatory response). CCL8 acts through binding to several different cell surface chemokine receptors, including CCR1, CCR2B, and CCR5 (one of the major co-receptors for HIV-1).. ...
Results Absence and reduced intracellular levels of 5-HT inhibited the secretion of zymogen granules both ex vivo and in vitro and altered cytoskeleton dynamics. In addition, absence of 5-HT resulted in attenuated pro-inflammatory response after induction of pancreatitis. TPH1−/− mice showed limited zymogen release, reduced expression of the pro-inflammatory chemokine MCP-1 and minimal leucocyte infiltration compared with wild-type animals. Restoration of 5-HT levels in TPH1−/− mice recovered the blunted inflammatory processes observed during acute pancreatitis. However, cellular damage, inflammatory and fibrotic processes accelerated in TPH1−/− mice during disease progression.. ...
Several genes encoding proapoptotic proteins also elevated expression right after NMDA injection: Amounts of Stat1 mRNA were significantly improved at 24 h, and caspase one mRNA was threefold and fourfold elevated in contrast to controls at 24 h and 48 h, respectively. In contrast, monocyte chemotactic protein 1 , a cytokine involved with recruiting white blood cells to websites of infection or inflammation , was similarly expressed from the NMDA and PBS handled retinas, despite the fact that a tendency for greater expression was detected in NMDA retinas at 24 h right after injection. Activation of a number of these molecules immediately after NMDA injection was also detecinhibitors on the protein level with western blotting . At 24 h soon after injection, we found strongly elevated levels of phospho STAT3, STAT3, phospho STAT1, and STAT1 from the NMDA taken care of retinas compared on the PBS injected controls. On top of that, expression of glial fibrillary acidic protein along with the proform ...
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Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F. Jr., Martinez-A C.. The chemokines are a growing family of low m.w., 70-to 80-residue proinflammatory cytokines that operate by interacting with G protein-coupled receptors. Chemokines are involved in cell migration and in the activation of specific leukocyte subsets. Using the Mono Mac 1 monocytic cell line, we show that monocyte chemotactic protein 1 (MCP-1) triggers activation of the Janus kinase 2 (JAK2)/STAT3 pathway and CCR2 receptor tyrosine phosphorylation. Both Ca2+ mobilization and cell migration are blocked in Mono Mac 1 cells by tyrphostin B42, a specific JAK2 kinase inhibitor. Within seconds of MCP-1 activation, JAK2 phosphorylates CCR2 at the Tyr139 position and promotes JAK2/STAT3 complex association to the receptor. This MCP-1-initiated phosphorylation and association to JAK2 is also observed in CCR2B-transfected HEK293 cells. In contrast, when a CCR2B Tyr139Phe mutant is ...
Chemokine (C-C motif) ligand 8--also known as monocyte chemoattractant protein 2 (MCP-2), HC14, SCYA8, or SCYA10--is a protein encoded by the CCL8 gene. The precursor protein (109 amino acids) is cleaved to produce mature CCL8 (75 amino acids). CCL8 activates many different immune cells, including mast cells, eosinophils, and basophils (implicated in allergic responses), and monocytes, T cells, and NK cells (involved in the inflammatory response). CCL8 acts through binding to several different cell surface chemokine receptors, including CCR1, CCR2B, and CCR5 (one of the major co-receptors for HIV-1).. ...
NEX313 Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor κB (NFκB). ...
LEAF™ |!Low Endotoxin, Azide-Free|Purified anti-human MCP-1 Antibody - Monocyte chemotactic protein-1 (MCP-1) also known as monocyte chemotactic and activating factor (MCAF) was identified based on its ability to chemoattract monocytes.
CCL7/MCP-3/MARC Proteins available through Novus Biologicals. Browse our CCL7/MCP-3/MARC Protein catalog backed by our Guarantee+.
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Clone REA328 recognizes the human C-C motif chemokine 7 (CCL7) antigen, an inflammatory cytokine also known as monocyte chemotactic protein 3 (MCP-3). Human CCL7 is secreted by several tumor cell lines and macrophages as a precursor protein containing 99 amino acids, including an aminoterminal hydrophobic signal sequence. It is one of the most broadly active chemokines, potently inducing chemotaxis of monocytes, basophils, eosinophils, and lymphocytes, as well as degranulation of basophils, eosinophils, and monocytes. Additional information: Clone REA328 displays negligible binding to Fc receptors. - Belgique
Three classes of drugs developed to treat HIV/AIDS work by preventing entry of the human immunodeficiency virus into the immune cells, preventing the virus from replicating and destroying the immune system. These classes (typically combined with two or more other HIV drugs) include fusion inhibitors, chemokine receptor antagonist (CCR5 antagonist) and post-attachment inhibitors.
Reaktivität: Meerschweinchen - Probe: Serum, Cell Culture Supernatant. | Chemokine (C-C Motif) Ligand 8 (CCL8) ELISA Kit (ABIN628807).
Monocyte Chemoattractant Protein 3 (MCP-3), also called CCL7, is produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1, CCR2, and CCR3. CCL7 chemoattracts monocytes and can regulate macrophage function. Alternate Names: CCL7, MARC
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We have all heard of proteins at one point or another in our life but do we really know what they are or do? Let´s find out. Proteins are made up of amino acids. There are 20 amino acids. These amino acids can be arranged in a million different ways to create millions of different…
Ccl2 - Ccl2 (untagged) - Mouse chemokine (C-C motif) ligand 2 (Ccl2), (10ug) available for purchase from OriGene - Your Gene Company.
This is the first chapter of something piedmargaret and I have been working on for a while now - a Spike/Ethan futurefic that diverges post-Chosen. Angel S5? What Angel S5? And by future, I mean post-apocalypse. And by fic, I mean. Um, actually I mean fic. Or possibly I mean WIP. Because it is. The…
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In an obese state, Toll-like receptor-4 (TLR-4) upregulates proinflammatory adipokines secretion including monocyte chemotactic protein-1 (MCP-1) in adipose tissue. In contrast, G-protein coupled receptor 120 (GPR120) mediates antiobesity effects. The aim of this study was to determine the signaling …
Mouse anti Human MCP-3 antibody, clone h.mcp.3 recognizes human C-C motif chemokine 7, also known as Monocyte chemoattractant protein 3, M
Onto the SGA fix index. The next one up will be my misc fic index which will have Firefly, Battlestar, Buffy and the single LOTR story I wrote plus any crossover fic... hee. Onto the SGA fic listing... Category; SGA Gen Mondays Child - Challenge fic - the Atlantis characters playing at Atlantis in…
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STING may play an important role in the production of MCP-1 and CCL7 chemokines. STING deficient monocytes are intrinsically ...
These factors include most particularly chemokines such as monocyte chemotactic protein-1 (CCL2) and monocyte chemotactic ... protein-3 (CCL7); certain arachidonic acid metabolites such as Leukotriene B4 and members of the 5-Hydroxyicosatetraenoic acid ...
C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. CCR1 has also recently been designated ... The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). ... "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1". Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, ... This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on ...
This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 ... It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine ... a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil ... an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". J ...
... and increases in certain pro-allergic chemokines such as eotaxin-2 and CCL7. NSAIDs-exacerbated cutaneous disease (NECD) is an ... 5-lipoxygenase and 15-lipoxygenase pro-inflammatory metabolites and the overproduction of certain pro-allergic chemokines, e.g ...
CCL2 and CCL7. PAR1 is inhibited by Vorapaxar when the molecule binds to a binding pocket between extracellular loop 2 and 3 of ... inflammatory response to Streptococcus pneumoniae by reducing levels of pro-inflammatory cytokines such as IL-1β and chemokines ...
... form the CCL7 chemokine which serves as a chemoattractant that guides sperm cells to oocytes and b) disassemble the ...
Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL5 CCL6 CCL7 ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... CR6261 CroFab Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 ...
... encoding protein Zinc finger protein 207 Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, ... C-C motif chemokine ligand 4 like 1 (17q12) DDX52: DExD-box helicase 52 (17q12) ERBB2 loca leukemia viral oncogene homolog 2, ...
CCL7, CCL8, CCL13, CCL17 and CCL22. T-lymphocytes: the four key chemokines that are involved in the recruitment of T ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ...
... has been shown to interact with MMP2 by binding CCR2 receptor. CCL7 is a multipotent chemokine involved in anti-bacterial ... CCL7 is encoded by the CCL7 gene which is one of the several chemokine genes clustered on chromosome 17q11.2-q12. This region ... Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). ... For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria ...
CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including CCL11, CCL26, CCL7, CCL13, CCL15, CCL24 and ... The CC chemokine receptors all work by activating the G protein Gi. CCR1 was the first CC chemokine receptor identified and ... CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to ... May 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1 ...
CCL7, CCL13, and CCL3. Chemokines CCL11 (eotaxin) and CCL5 (RANTES) acts through a specific receptor CCR3 on the surface of ... C chemokinesEdit. The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... CC chemokinesEdit. The CC chemokine (or β-chemokine) proteins have two adjacent cysteines (amino acids), near their amino ...
chemokine receptor activity. • receptor activity. • protein binding. • C-C chemokine receptor activity. • C-C chemokine binding ... Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[5] CCR6 ... "Entrez Gene: CCR6 chemokine (C-C motif) receptor 6".. *^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, ... "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL18, and CCL23 ...
positive regulation of chemokine (C-X-C motif) ligand 2 production. • positive regulation of JUN kinase activity. • positive ... positive regulation of chemokine production. • cellular extravasation. • negative regulation of lipid storage. • negative ... positive regulation of chemokine biosynthetic process. • epithelial cell proliferation involved in salivary gland morphogenesis ...
... s are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte.[1] They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells. Lymphokines have many roles, including the attraction of other immune cells, including macrophages and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response. Circulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is required. Lymphokines aid B cells to produce antibodies. Important lymphokines secreted by the T helper cell include:[2] ...
... binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is caspase-8-dependent. Caspase-8 activates downstream effector caspases including procaspase-3, -6, and -7, leading to activation of specific kinases.[11] TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation. Application of engineered ligands that have variable affinity for different death (DR4 and DR5) and decoy receptors (DCR1 and DCR2) may allow selective targeting of cancer cells by controlling activation of Type 1/Type 2 pathways of cell death and single cell fluctuations. Luminescent iridium complex-peptide ...
... (IL-24) is a protein that in humans is encoded by the IL24 gene. IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells[5] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer.[6][7][8] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[9][10] The gene for IL-24 is located on chromosome 1 in humans.[11] ...
... as well as chemokine and cytokine production, and expression of adhesion molecules such as E-selectin, ICAM-1, and VCAM-1. This ...
positive regulation of chemokine biosynthetic process. • regulation of insulin secretion. • extrinsic apoptotic signaling ... Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12 ...
... is sometimes used interchangeably among scientists with the term cytokine.[3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes). For the circulatory system and bone marrow in which cells can occur in a liquid suspension and not bound up in solid tissue, it makes sense for them to communicate by soluble, circulating protein molecules. However, as different lines of research converged, it became clear that some of the same signaling proteins which the hematopoietic and immune systems use were also being used by all sorts of other cells and tissues, during development and in the mature organism. While growth factor implies a positive effect on cell division, cytokine is a neutral term with respect to whether a molecule affects proliferation. While some cytokines can be growth factors, such as G-CSF and GM-CSF, others have an inhibitory effect on ...
chemokine activity. • cytokine activity. • heparin binding. • protein binding. • CXCR3 chemokine receptor binding. ... C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T- ... "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11".. *^ a b Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue ... This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a ...
Interferon alfa 2b is an antiviral or antineoplastic drug, that was originally discovered in the laboratory of Charles Weissmann at the University of Zurich. It was developed at Biogen, and ultimately marketed by Schering-Plough under the tradename Intron-A. It has been used for a wide range of indications, including viral infections and cancers. This drug is approved around the world for the treatment of chronic hepatitis C, chronic hepatitis B, hairy cell leukemia, Behçet's disease, chronic myelogenous leukemia, multiple myeloma, follicular lymphoma, carcinoid tumor, mastocytosis and malignant melanoma. ...
4-1BB is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, expressed on activated T Lymphocytes.[1] 4-1BBL (4-1BB ligand) is found on APCs (antigen presenting cells) and binds to 4-1BB. ...
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[8]. ...
Chemokine. CCL. CCL1 · CCL2 · CCL3 · CCL4 · CCL5 · CCL6 · CCL7 · CCL8 · CCL9 · CCL11 · CCL12 · CCL13 · CCL14 · CCL15 · CCL16 · ...
... has been shown to interact with: CCL7, THBS2, TIMP2, TIMP4, and Thrombospondin 1. GRCh38: Ensembl release 89: ... IL-1β and various chemokines. For instance, MMP-2 has been implicated, along with MMP-9 in cleaving latent TGF-β, which has ... chemokines and their receptors]". Postepy Biochem. 53 (1): 37-45. PMID 17718386. The MEROPS online database for peptidases and ...
C-X-C chemokine receptor activity. • interleukin-8 binding. • G-protein coupled receptor activity. • chemokine receptor ... This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 ... "Chemokine Receptors: CXCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... chemokine-mediated signaling pathway. • interleukin-8-mediated signaling pathway. • neutrophil degranulation. • chemotaxis. ...
CCL7 has been shown to interact with MMP2 by binding CCR2 receptor. CCL7 is a multipotent chemokine involved in anti-bacterial ... CCL7 is encoded by the CCL7 gene which is one of the several chemokine genes clustered on chromosome 17q11.2-q12. This region ... Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). ... For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria ...
CCL7) in Cell culture supernatant, Serum, Hep Plasma, EDTA Plasma, Cit plasma… ... CCL7) is a single-wash 90-min SimpleStep ELISA® for the quantitative measurement of Human MCP3 ( ... MCP3 (CCL7) is a monomeric secreted chemotactic factor of intercrine (chemokine cc) family. MCP3 attracts monocytes and ... Quantitate Human MCP3 (CCL7) with 10.3 pg/ml sensitivity.. SimpleStep ELISA® technology employs capture antibodies conjugated ...
sp,P80098,CCL7_HUMAN C-C motif chemokine 7 OS=Homo sapiens OX=9606 GN=CCL7 PE=1 SV=3 ... IPR039809, Chemokine_b/g/d. IPR000827, Chemokine_CC_CS. IPR001811, Chemokine_IL8-like_dom. IPR036048, Interleukin_8-like_sf ... IPR039809, Chemokine_b/g/d. IPR000827, Chemokine_CC_CS. IPR001811, Chemokine_IL8-like_dom. IPR036048, Interleukin_8-like_sf ... CCR2 chemokine receptor binding Source: Ensembl. *CCR chemokine receptor binding Source: GO_Central ,p>Inferred from Biological ...
... chemokines often bind more than one chemokine receptor, and chemokine receptors typically bind more than one class of chemokine ... Alternatively, CCL7 may facilitate neutrophil chemoattraction by a second chemokine, similar to the facilitatory role of CCL7 ... 8⇓, anti CXCL10 recognized CXCL10 but not KC, CCL7, and CCL5. Likewise, the Abs to CCL7 and KC specifically recognized CCL7 and ... To detect these chemokines or chemokine receptors, Western blotting was performed using rabbit anti-murine chemokine Abs ( ...
These findings indicate that CCL7 and CXCL10, two chemokines not previously reported to orchestrate neutrophilic inflammation, ... O3 increased lung protein levels of CXCL10, CCL7, and CCR3 (CCL7R). The airway epithelium was identified as a source of CCL7. ... The role of up-regulated chemokines was determined by administering control IgG or IgG Abs against six murine chemokines before ... CCL7 (monocyte chemoattractant protein-3), and CCL11 (eotaxin) at 0 h postexposure, and expression of CXCL10, CCL3, and CCL7 ...
Mouse Monoclonal Anti-CCL7/MCP-3/MARC Antibody (36320) [Alexa Fluor® 700]. Validated: Flow. Tested Reactivity: Human. 100% ... Alternate Names for CCL7/MCP-3/MARC Antibody (36320) [Alexa Fluor® 700]. *C-C motif chemokine 7 ... Home » CCL7/MCP-3/MARC » CCL7/MCP-3/MARC Antibodies » CCL7/MCP-3/MARC Antibody (36320) [Alexa Fluor® 700] ... CCL7/MCP-3/MARC Antibody (36320) [Alexa Fluor® 700] Summary. Immunogen. E. coli-derived recombinant human CCL7/MCP-3/MARC. ...
CCL7) Protein (His tag). Spezies: Human. Quelle: Escherichia coli (E. coli). Jetzt Produkt ABIN2004891 bestellen. ... Chemokine (C-C Motif) Ligand 7 (CCL7) Synonyme für dieses Antigen anzeigen * CCL7 ... Chemokine (C-C Motif) Ligand 7 (CCL7) (AA 24-99), (Mature) protein (His tag). Details zu Produkt Nr. ABIN2004891, Anbieter: ... Chemokine (C-C Motif) Ligand 7 (CCL7) (AA 24-99), (Mature) protein (His tag) Produktdetails lesen ...
Chemokines, Cytokines and chemokines and related molecules. Summary. Monocyte chemotactic protein 3 (MCP3)(CCL7) is secreted by ... CCL7. By Technical Data. CCL7 - Proteins. CCL7 - Recombinant+protein - Proteins. Human - CCL7 - Proteins. CCL7 - for Western+ ... CCL7 - for Cell+culture+and%2for+animal+studies - Proteins. CCL7 - for Biologically+active+protein - Proteins. CCL7 - from E.+ ... Chemokines. Cytokines and chemokines and related molecules. By Molecule. ...
CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 ... it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates ... This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most ... Small inducible cytokine A7, CCL7, Monocyte chemotactic protein 3, MCP-3, Monocyte chemoattractant protein 3, NC28, chemokine ( ...
CCL7 , C-C motif chemokine 7 , Chemokine (C-C motif) ligand 7 , FIC , MARC , MCP3 , Monocyte chemotactic protein 3 , SCYA7 , ... This CCL7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from ... MCP3 antibody LS-C253753 is an AP-conjugated rabbit polyclonal antibody to human MCP3 (CCL7) (aa25-54). Validated for ELISA and ... Polyclonal Rabbit anti‑Human CCL7 / MCP3 Antibody (AP, aa25‑54, WB) LS‑C253753 ...
It is one of the most broadly active chemokines, potently inducing chemotaxis of monocytes, basophils, eosinophils, and ... CCL7) antigen, an inflammatory cytokine also known as monocyte chemotactic protein 3 (MCP-3). Human CCL7 is secreted by several ... Clone REA328 recognizes the human C-C motif chemokine 7 ( ... Clone REA328 recognizes the human C-C motif chemokine 7 (CCL7) ... It is one of the most broadly active chemokines, potently inducing chemotaxis of monocytes, basophils, eosinophils, and ...
It is one of the most broadly active chemokines, potently inducing chemotaxis of monocytes, basophils, eosinophils, and ... CCL7) antigen, an inflammatory cytokine also known as monocyte chemotactic protein 3 (MCP-3). Human CCL7 is secreted by several ... Clone REA328 recognizes the human C-C motif chemokine 7 ( ... Clone REA328 recognizes the human C-C motif chemokine 7 (CCL7) ... Clone REA328 recognizes the human C-C motif chemokine 7 (CCL7) antigen, an inflammatory cytokine also known as monocyte ...
Browse our CCL7/MCP-3/MARC Protein catalog backed by our Guarantee+. ... CCL7/MCP-3/MARC Proteins available through Novus Biologicals. ... CCL7/MCP-3/MARC protein, CCL7 protein, C-C motif chemokine 7 ... CCL7/MCP-3/MARC Proteins. We offer CCL7/MCP-3/MARC Peptides and CCL7/MCP-3/MARC Proteins for use in common research ... Our CCL7/MCP-3/MARC Peptides and CCL7/MCP-3/MARC Proteins can be used in a variety of model species: Human, Mouse, Rat. Use the ...
Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-chemotactic ... it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates ... Human CCL7 genome location and CCL7 gene details page in the UCSC Genome Browser. ... Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". ...
It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein ... Home , Life Science Research , Products , PCR Amplification , PrimePCR™ PCR Primers, Assays, and Arrays , Gene: CCL7, Human , ... PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CCL7, Human. print ddPCR™ Evagreen assay for gene expression analysis. EvaGreen ... This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq Jul 2008] ...
Mouse chemokine (C-C motif) ligand 7 ELISA Kit-NP_038682.1 (MBS701687) product datasheet at MyBioSource, ELISA Kits ... Chemokine Signaling Pathway antibodies. Chemokine Signaling Pathway Diagram. Chemokine Signaling Pathway antibodies. Chemokine ... Chemokine Receptors Bind Chemokines Pathway antibodies. Chemokine Receptors Bind Chemokines Pathway Diagram. ... chemokine (C-C motif) ligand 7 (CCL7), ELISA Kit. ★Popular Item★ Also Known As Mouse monocyte chemotactic protein 3, MCP-3 ...
CCL7 (MCP-3) (Biotinylated) Rec. Prot. \ RD172387002-BIOTIN for more molecular products just contact us ... Related products : CCL7 (MCP-3) (Biotinylated) Rec. Prot.. Gentaurpub. Pathways :. WP2292: Chemokine signaling pathway. Related ... RD172387002-BIOTIN CCL7 (MCP-3) (Biotinylated) Rec. Prot. Ask technical file .. Price. : Ask Price ! Product name : CCL7 (MCP-3 ... We have also other products like : CCL7 (MCP-3) (Biotinylated) Rec. Prot.. Related products : CCL7 (MCP-3) (Biotinylated) Rec. ...
Chemokine_CX3C - cd00274 Chemokine_C - cd00271 SCY - smart00199 Chemokine_CC_DCCL - cd01119 Chemokine_CC - cd00272 Chemokine - ... Chemokine_C - cd00271 IL8 - pfam00048 SCY - smart00199 Chemokine_CC - cd00272 Chemokine - cd00169 Chemokine_CC_DCCL - cd01119 ...
backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations ... 11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13 ... backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations ...
backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations ... 17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11 ... backgroundmonocyte ccl3 ccl4 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations ...
Cusabio offers CCL7 related Antibodies, Proteins, cDNA and ELISA Kits. We also illustrate the related signaling pathways ... CCL7. CCL7. C-C motif chemokine 7 is a protein in humans that is encoded by CCL7 gene. Chemotactic factor that attracts ... Recombinant Human C-C motif chemokine 7(CCL7). Yeast. E.coli. Baculovirus. Mammalian cell. In Vivo Biotinylation in E.coli. ... Recombinant Rat C-C motif chemokine 7(Ccl7). Yeast. E.coli. Baculovirus. Mammalian cell. In Vivo Biotinylation in E.coli. ...
MCP-3/CCL7 is a member of the C-C subfamily of chemokines, which have two adjacent cysteine residues, and is a ligand for CCR1 ... CCL7. A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 3 (MCP-3), a secreted chemokine that attracts ...
CCL7) Protein (Recombinant) datasheet and description hight quality product and Backed by our Guarantee ... CCL7 and IDBG-40580 and ENSG00000108688 and 6354, CCR2 chemokine receptor binding, Ccl7 and IDBG-204496 and ENSMUSG00000035373 ... CCR1 chemokine receptor binding, this GO :0031727 : CCR2 chemokine receptor binding, chemokine (C-C motif) ligand 7. ... chemokine activity, this GO :0008009 : chemokine activity and also this GO :0008201 : heparin binding and also this GO :0031726 ...
CCL7 (also known as MCP-3) specifically attracts monocytes, and regulates macrophage function. The Feline CCL7 recombinant ... as an CCL7 ELISA Standard, and as a Western Blot Control. ... The Feline CCL7 recombinant protein can be used in cell culture ... Alternate names - CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 7 ... Panthera pardus (leopard) CCL7 - 100%. Panthera tigris altaica (Amur tiger) CCL7 - 100%. Puma concolor (puma) CCL7 - 100%. More ...
rHuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA6; SCYA7 ; 重组人单核细胞趋化蛋白-3/CCL7. Species Human ... CCL7 is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils. CCL7 is ... Abnormal CCL7 expression is associated with certain immune diseases. CCL7 alsoplays a pivotal role in tumorigenesis[1].. ... Reconstitute the lyophilized recombinant Human Monocyte Chemotactic Protein-3/CCL7 (rHuMCP-3/CCL7) to 0.1-1.0 mg/mL using ...
Ccl7) (Active) von Cusabio bei SZABO-SCANDIC erhältlich. Weiteres zu Proteine & Peptide finden Sie hier. ... Recombinant Mouse C-C motif chemokine 7 protein(Ccl7) (Active), Host: E.Coli ... Recombinant Mouse C-C motif chemokine 7 protein( ... Recombinant Mouse C-C motif chemokine 7 protein(Ccl7) (Active) ...
This review will focus on recent murine and human studies that use chemokines as therapeutic anti-cancer vaccine adjuvants. ... Recent discoveries in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing ... This knowledge, combined with advances in gene therapy and virology, allows researchers to employ chemokines as potential ... was genetically fused to chemokines CCL7, CXCL10 [54] and CCL20 [53]. Immunization with chemokine-sFv protein elicited a T-cell ...
CCL7. chemokine (C-C motif). ligand 7. 1.4. 12.2. NM_002984. CCL4. chemokine (C-C motif). ... The method according to claim 12 wherein the one or more genes comprises MT3, TNFSF7, BTG1, IL-6, IL-8, IL1b, CCL4, CCL7, IFNG ... 15 Induction of transcription of IL-6, IL-8, IL-1b, MIP1b cytokine/chemokines by MGCD0103 in peripheral white cells ex vivo ... 14). Then, induction of transcription of IL-6, IL-8, IL-1b, MIP1b cytokine/chemokines by MGCD0103 was shown in peripheral white ...
CCL2 and CCL7 are elevated in ARDS BAL fluid. We have previously reported that the chemokines CCL2 and CCL7 are elevated in the ... Chemokine (C-X-C motif) ligand 8 (CXCL8), chemokine (C-C motif) ligand (CCL)2 and CCL7 contribute to the neutrophil chemotactic ... CCL2 and CCL7 have been shown to differentially induce the chemotaxis of macrophages, with CCL7 being the only chemokine to ... is mediated by the chemokine (C-C motif) ligand (CCL)2 and CCL7,12 while CCL7 regulates neutrophil recruitment in response to ...
Both MCP2 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively ... Human MCP-3 (CCL7) Bio Basic Inc.. MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma ... Fractalkine, also named neurotactin, is a novel chemokine recently identified through bioinformatics. Fractalkine has a unique ... C-X3-C cysteine motif near the amino-terminus and is the first member of a fourth branch of the chemokine superfamily. Unlike ...
  • Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3). (wikipedia.org)
  • MBS701687 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the chemokine (C-C motif) ligand 7 (CCL7) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • MCP-3/CCL7 is a member of the C-C subfamily of chemokines, which have two adjacent cysteine residues, and is a ligand for CCR1, CCR2 and CCR3. (thefreedictionary.com)
  • Most chemokines bind to more than one receptor, while most receptors also display overlapping ligand specificity [ 5 ]. (mdpi.com)
  • This study aimed at determining the role of the chemokine (C-C motif) ligand (CCL)2 and CCL7 in ARDS. (bmj.com)
  • Neutrophil chemotaxis to ARDS BAL fluid was evaluated and the contribution of each was assessed and compared with chemokine (C-X-C motif) ligand 8 (CXCL8). (bmj.com)
  • To what extent do the chemokine (C-C motif) ligand (CCL)2 and CCL7 contribute to the migratory activity of neutrophils during acute respiratory distress syndrome (ARDS)? (bmj.com)
  • Both CCL2 and CCL7 contribute to neutrophil chemotaxis during ARDS by synergising with chemokine (C-X-C motif) ligand 8. (bmj.com)
  • Receptor-ligand promiscuity is a hallmark of the inflammatory CC-chemokine/receptor system, where most ligands bind more than one receptor and most receptors bind more than one ligand. (aspetjournals.org)
  • CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. (genecards.org)
  • SCYA2 , also known as CC chemokine ligand 2 [CCL2]), a C-C motif chemokine, is important for recruiting macrophage precursors, monocytes, into atherosclerotic tissue and other chronic inflammatory lesions ( 14 - 16 ). (diabetesjournals.org)
  • Chemokine (C-C motif) ligand 8--also known as monocyte chemoattractant protein 2 (MCP-2), HC14, SCYA8, or SCYA10--is a protein encoded by the CCL8 gene. (clontech.com)
  • Meta-analysis of the cell proportion-adjusted gene expression data suggested that an increase in inflammatory macrophages in anti-TNFα non-responding individuals is associated with the upregulation of the triggering receptor expressed on myeloid cells 1 (TREM-1) and chemokine receptor type 2 (CCR2)-chemokine ligand 7 (CCL7) -axes. (bmj.com)
  • In contrast to other "silent" or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. (rupress.org)
  • These receptors are also referred to as professional chemokine "interceptors," a name which reflects their ability to efficiently internalize bound ligand ( 12 ). (rupress.org)
  • Two nomenclature systems are used in the current literature, the traditional abbreviations dating back to the time of chemokine discovery, such as interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1, and a systematic nomenclature that combines structural motifs (CXC, CC, XC, CX3C) with L for ligand and the number of the respective gene ( http://cytokine.medic.kumamoto-u.ac.jp gives access to recent updates 3 ). (bmj.com)
  • The receptor has a consensus site for tyrosine sulfation, which affects the affinity and binding of some chemokine receptors to their ligand(s) and has been. (springer.com)
  • In the present study we investigated the effect of mutations in the GAG binding sites of three chemokines, monocyte chemoattractant protein-1/CC chemokine ligand (CCL)2, macrophage-inflammatory protein-1β/CCL4, and RANTES/CCL5, on their ability to recruit cells in vivo . (pnas.org)
  • For example, N-methylation of Leu-25 in the CXC chemokine IL-8/CXC chemokine ligand 8 produces a monomer that is fully functional in vitro ( 7 ). (pnas.org)
  • For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria monocytogenes infections by the recruitment of monocytes and TNF/iNOS-producing dendritic cells (TipDCs). (wikipedia.org)
  • CCL7 is widely expressed in multiple cell types and can participate in anti-inflammatory responses through binding to its receptors to mediate the recruitment of immune cells. (klamar-reagent.com)
  • To date, there are more than 50 chemokines and 18 chemokine receptors identified [ 6 ]. (mdpi.com)
  • All of these proteins exert their biological effects by interacting with G protein -linked transmembrane receptors called chemokine receptors , that are selectively found on the surfaces of their target cells. (wikipedia.org)
  • Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)
  • Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)
  • Pharmacologic mechanisms that may in part account for these differences are difficult to assess on primary cells and in in vivo systems because of the presence of alternative receptors and the confounding variety of regulatory mechanisms of the chemokine response. (aspetjournals.org)
  • For example, binding preferences and activity of a given chemokine are modulated by proteoglycan binding, protease processing, and oligomerization of chemokines as well as chemokine receptors, adding several layers of complexity. (aspetjournals.org)
  • Knowledge about intrinsically different effects of different chemokines on the same receptor should help to better direct drug developing efforts targeting chemokine receptors. (aspetjournals.org)
  • Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (wikipathways.org)
  • It binds to chemokine receptors CCR2 and CCR4. (genecards.org)
  • By analyzing chemokines secreted by PPAT adipocytes they identified the factors involved, in particular chemokine CCL7, which interacts with one of its receptors, CCR3, present on the surface of prostate tumor cells. (eurasiareview.com)
  • They assist with the study of chemokines, cytokines, growth factors and their associated receptors, adaptive and innate immunity, and the complement and coagulation cascades. (cellsciences.com)
  • Interleukin-8/CXCL8 and stromal cell-derived factor-1/CXCL12 significantly and dose-dependently increased the migration of monocytes, expressing the corresponding CXC chemokine receptors CXCR2 and CXCR4, toward suboptimal concentrations of the monocyte chemotactic proteins CCL2 or CCL7. (aspetjournals.org)
  • These data show that chemokines competing for related receptors and using similar signaling pathways do not synergize. (aspetjournals.org)
  • These data indicate that for synergistic interaction between chemokines binding and signaling of the two chemokines via their proper receptors is necessary. (aspetjournals.org)
  • CCL8 acts through binding to several different cell surface chemokine receptors, including CCR1, CCR2B, and CCR5 (one of the major co-receptors for HIV-1). (clontech.com)
  • However, CCRL2 possesses an uncharacteristic intracellular loop 2 sequence in place of the DRYLAIV motif generally found in signaling chemokine receptors (QRYLVFL in huCCRL2 and QRYRVSF in mCCRL2), leading us to postulate that it might be an "atypical" silent or nonsignaling receptor. (rupress.org)
  • These receptors also lack the consensus DRYLAIV-related sequence present in the second intracellular loop domain of most chemokine receptors, possibly accounting for their inability to transduce classical intracellular signals (the sequence is DKYLEIV in D6, LGHRLGA in DARC, and DRYWAIT in CCX-CKR). (rupress.org)
  • Three of these proteins (MCP-3/CCL7, MIG/CXCL9, IP-10/CXCL10) were chemokines, while the other three (DNER, CD40, TNFRSF9) were soluble forms of transmembrane receptors. (eurekalert.org)
  • 4- 6 Chemokine receptors are designated according to the type of chemokine(s) they bind (CXC, CC, XC, CX3C), followed by R for receptor and a number indicating the order of discovery. (bmj.com)
  • Chemokine receptors belong to the large family of seven transmembrane domain receptors which couple to heterotrimeric GTP-binding proteins (G-proteins) (fig 1). (bmj.com)
  • Chemokines in transplantation: what can atypical receptors teach us about anti-inflammatory therapy? (healthtap.com)
  • The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. (peprotech.com)
  • They mediate their activity by binding to cell surface chemokine receptors that belong to the G-protein coupled receptor (GPCR) superfamily. (springer.com)
  • During organogenesis, immunosurveillance, and inflammation, chemokines selectively recruit leukocytes by activating seven-transmembrane-spanning receptors. (pnas.org)
  • Many chemokines bind several receptors and multiple chemokines often bind the same receptor, resulting in a highly complex network of interactions ( 3 ). (pnas.org)
  • MCP-2 and CCL7 are two monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. (novusbio.com)
  • Similarly to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. (novusbio.com)
  • We offer CCL7/MCP-3/MARC Peptides and CCL7/MCP-3/MARC Proteins for use in common research applications: ELISA, Functional, Protein Array, SDS-Page, Western Blot. (novusbio.com)
  • Our CCL7/MCP-3/MARC Peptides and CCL7/MCP-3/MARC Proteins can be used in a variety of model species: Human, Mouse, Rat. (novusbio.com)
  • Choose from our CCL7/MCP-3/MARC Peptides and Proteins. (novusbio.com)
  • MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. (thomassci.com)
  • Chemokines (Greek -kinos , movement) are a family of small cytokines , or signaling proteins secreted by cells . (wikipedia.org)
  • Cytokine proteins are classified as chemokines according to behavior and structural characteristics. (wikipedia.org)
  • Chemokines are a family of small cytokines , or proteins secreted by cells . (wikidoc.org)
  • Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikidoc.org)
  • Proteins are classified into the chemokine family based on their structural characteristics, not just their ability to attract cells. (wikidoc.org)
  • Typical chemokine proteins are produced as pro-peptides , beginning with a signal peptide of approximately 20 amino acids that gets cleaved from the active (mature) portion of the molecule during the process of its secretion from the cell. (wikidoc.org)
  • Chemokines are small cytokines, or signaling proteins, secreted by cells. (wikipathways.org)
  • Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. (genecards.org)
  • Chemokines are a family of small cytokines, or proteins secreted by cells, with a molecular mass between 8 and 10 kDa. (genscript.com)
  • GenScript offers a comprehensive catalog of chemokine proteins with excellent lot-to-lot consistency, superior activity and significantly low endotoxin levels. (genscript.com)
  • Among these signals, small molecular weight chemoattractant proteins known as chemokines are potentially important contributors as they participate in both directing leukocyte migration and function. (frontiersin.org)
  • Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. (creativebiomart.net)
  • Both aspects, cell adhesion and chemotaxis, are regulated by members of the family of chemotactic cytokines (chemokines) comprising structurally related and secreted proteins of 67-127 amino acids in length. (bmj.com)
  • Chemokines represent a large group of chemotactic proteins, with more than 50 members that regulate the trafficking and activation of immune cells. (springer.com)
  • CCL7 has been shown to interact with MMP2 by binding CCR2 receptor. (wikipedia.org)
  • Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2(-/-) mice. (nih.gov)
  • The chemokine receptor CCR2, which has been implicated in a variety of inflammatory, autoimmune, and cardiovascular conditions, binds several natural chemokine ligands. (aspetjournals.org)
  • Moreover, qualitative differences between the arrestin responses to the different ligands were identified in the stability of the response: although CCL7-induced arrestin recruitment had a half-life of less than 15 min, CCL8 and CCL13 induced stable CCR2-arrestin interactions. (aspetjournals.org)
  • The chemokine receptor CCR2 is of significant clinical interest because it has been implicated in inflammatory and cardiovascular disease. (aspetjournals.org)
  • MCP-1 interacts with its receptor, CC chemokine receptor 2 (CCR2), on the surface of monocytes to initiate signaling, which ultimately leads to cell adhesion and tissue infiltration ( 21 , 22 ). (diabetesjournals.org)
  • Receptor heterodimerization is probably not essential for chemokine synergy as shown in CXCR4/CCR2 cotransfectants. (aspetjournals.org)
  • Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration. (peprotech.com)
  • CCL7 is a small protein that belongs to the CC chemokine family and is most closely related to CCL2 (previously called MCP1). (wikipedia.org)
  • Human MCP3 ELISA Kit (CCL7) (ab193769) is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of MCP3 (CCL7) protein in cell culture supernatant, cit plasma, edta plasma, hep plasma, and serum. (abcam.com)
  • The 0.8 ppm O 3 up-regulated lung mRNA of CXCL1,2,3 (mouse growth-related oncogene-α and macrophage-inflammatory protein-2), CXCL10 (IFN-γ-inducible protein-10), CCL3 (macrophage-inflammatory protein-1α), CCL7 (monocyte chemoattractant protein-3), and CCL11 (eotaxin) at 0 h postexposure, and expression of CXCL10, CCL3, and CCL7 mRNA was sustained 18 h postexposure. (jimmunol.org)
  • O 3 increased lung protein levels of CXCL10, CCL7, and CCR3 (CCL7R). (jimmunol.org)
  • CCL7 cDNA encodes a 99 amino acid residue precursor protein from which the N-terminal 23 amino acid residues are cleaved to generate the 76 amino acid residue mature CCL7. (novusbio.com)
  • Dieses CCL7 Protein ist gelabelt mit His tag. (antikoerper-online.de)
  • Protein Structure: A DNA sequence encoding the mature form of human CCL7 (NP_006264.2) (Gln 24-Leu 99) was expressed, with a polyhistide tag at the N-terminus. (antikoerper-online.de)
  • Monocyte chemotactic protein 3 (MCP3)(CCL7) is secreted by monocytes and certain tumer cell lines. (biovendor.com)
  • Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. (prospecbio.com)
  • Lyophilized MCP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). (prospecbio.com)
  • Clone REA328 recognizes the human C-C motif chemokine 7 (CCL7) antigen, an inflammatory cytokine also known as monocyte chemotactic protein 3 (MCP-3). (miltenyibiotec.com)
  • Human CCL7 is secreted by several tumor cell lines and macrophages as a precursor protein containing 99 amino acids, including an aminoterminal hydrophobic signal sequence. (miltenyibiotec.com)
  • 1993) Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (miltenyibiotec.com)
  • Each CCL7/MCP-3/MARC Peptide and CCL7/MCP-3/MARC Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • This gene encodes monocyte chemotactic protein 3 a secreted chemokine which attracts macrophages during inflammation and metastasis. (bio-rad.com)
  • C-C motif chemokine 7 is a protein in humans that is encoded by CCL7 gene. (cusabio.com)
  • A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 3 (MCP-3), a secreted chemokine that attracts macrophages during inflammation and metastasis. (thefreedictionary.com)
  • The Feline CCL7 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. (kingfisherbiotech.com)
  • The Feline CCL7 recombinant protein has a predicted molecular weight of 9.0 kDa. (kingfisherbiotech.com)
  • The Feline CCL7 endotoxin-free recombinant protein can be used in cell culture, as an CCL7 ELISA Standard, and as a Western Blot Control. (kingfisherbiotech.com)
  • Reconstitute the lyophilized recombinant Human Monocyte Chemotactic Protein-3/CCL7 (rHuMCP-3/CCL7) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. (klamar-reagent.com)
  • Lyophilized recombinant Human Monocyte Chemotactic Protein-3/CCL7 (rHuMCP-3/CCL7) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. (klamar-reagent.com)
  • Protein Families: Intercrine beta (chemokine CC) family. (szabo-scandic.com)
  • Methods CCL2 and CCL7 protein levels were measured in bronchoalveolar lavage (BAL) fluid obtained from lipopolysaccharide(LPS)-challenged human volunteers and two separate cohorts of patients with ARDS. (bmj.com)
  • Intramolecular disulphide bonds typically join the first to third, and the second to fourth cysteine residues, numbered as they appear in the protein sequence of the chemokine. (wikidoc.org)
  • The first two cysteines, in a chemokine, are situated close together near the N-terminal end of the mature protein, with the third cysteine residing in the centre of the molecule and the fourth close to the C-terminal end . (wikidoc.org)
  • This is why we offer customized antibody production that can be tailored to detect a specific cytokine protein or chemokines protein that is necessary for the success of your research. (prosci-inc.com)
  • OBJECTIVE- Monocyte chemoattractant protein-1 (MCP-1), a CC-motif chemokine, has been proposed to play critical roles in insulin resistance and recruitment of monocytes into adipose tissue. (diabetesjournals.org)
  • This leukocyte recruitment is tightly regulated by the interplay between endothelial cells and leukocytes, a process in which G protein-coupled receptor (GPCR) agonists, including complement factor C5a, bacterial peptides (e.g., fMLP), and chemokines, play a central role. (aspetjournals.org)
  • Subsequently, the inflammatory CC chemokine monocyte chemotactic protein-3 (CCL7/MCP-3), which is a weak neutrophil chemoattractant, was found to dose-dependently enhance the neutrophil influx toward a suboptimal concentration of CXCL8. (aspetjournals.org)
  • The most recent chemokine binding protein is a structural variant of CXCR3, termed CXCR3-B, which binds the classical CXCR3 ligands: monokine induced by interferon γ (Mig)/CXCL9, interferon α inducible protein 10 (IP10)/CXCL10, and interferon inducible T cell alpha chemoattractant (I-TAC)/CXCL11 as well as platelet factor 4/CXCL4. (bmj.com)
  • Recombinant Murine JE is a 13.8 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. (peprotech.com)
  • Recombinant Murine Eotaxin is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. (peprotech.com)
  • Structure and function of A41, a vaccinia virus chemokine binding protein. (peprotech.com)
  • The chemokine macrophage-inflammatory protein-1 alpha and its receptor CCR1 control pulmonary inflammation and antiviral host defense in paramyxovirus infection. (springer.com)
  • An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. (springer.com)
  • Furthermore, several studies have shown that variants of chemokines with altered dimer interfaces remain monomeric even at high protein concentrations and yet are indistinguishable from wild-type chemokines in receptor binding and activation assays in vitro . (pnas.org)
  • Quantitate Human MCP3 (CCL7) with 10.3 pg/ml sensitivity. (abcam.com)
  • MCP3 (CCL7) is a monomeric secreted chemotactic factor of intercrine (chemokine cc) family. (abcam.com)
  • MCP3 antibody LS-C253753 is an AP-conjugated rabbit polyclonal antibody to human MCP3 (CCL7) (aa25-54). (lsbio.com)
  • However, very little is known about chemokines that orchestrate oxidative stress-induced neutrophilic airway inflammation in vivo. (jimmunol.org)
  • These findings indicate that CCL7 and CXCL10, two chemokines not previously reported to orchestrate neutrophilic inflammation, play a critical role in mediating oxidative stress-induced neutrophilic airway inflammation. (jimmunol.org)
  • Monocyte recruitment to sites of inflammation is regulated by members of the chemokine family of chemotactic cytokines. (nih.gov)
  • While some chemotaxis is induced by inflammation or damaged cells, other chemokines function in homeostasis. (biolegend.com)
  • Within this area, specific interests include the role of cc chemokines in inflammation, their interaction with cell surface glycosaminoglycans and signal transduction mechanisms mediated by them. (ncl.ac.uk)
  • My work so far has helped in clearly defining the role of chemokines in inflammation with particular relevance to transplantation. (ncl.ac.uk)
  • However recent substrate identification studies reveal that MMPs are regulating the release or activation of chemokines, cytokines, growth factors, antibiotic peptides, and other bioactive molecules thus participating in physiological processes such as innate and adaptive immunity, inflammation, angiogenesis, bone remodelling, and neurite growth. (ersjournals.com)
  • Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. (healthtap.com)
  • Therapy with nonglycosaminoglycan-binding mutant CCL7: a novel strategy to limit allograft inflammation. (healthtap.com)
  • Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. (peprotech.com)
  • Since inflammatory responses are another characteristic of the peritoneum in EOC, we also discuss the linkage between the coagulation cascade and the cytokines/chemokines involved in inflammation. (biomedcentral.com)
  • Interleukin-8, which is considered an important chemokine associated with tumor progression, appears to be a linkage point for coagulation and inflammation in malignancy. (biomedcentral.com)
  • In the human genome, CCL7 is encoded by the CCL7 gene which is one of the several chemokine genes clustered on chromosome 17q11.2-q12. (wikipedia.org)
  • This region contains the gene for the MCP subset of CC chemokines. (wikipedia.org)
  • The CCL7 gene has been given the locus symbol SCYA7. (wikipedia.org)
  • Human CCL7 genome location and CCL7 gene details page in the UCSC Genome Browser . (wikidoc.org)
  • This gene is part of a cluster of C-C chemokine family members on chromosome 17q. (bio-rad.com)
  • NCBI/Uniprot data below describe general gene information for CCL7 . (mybiosource.com)
  • This knowledge, combined with advances in gene therapy and virology, allows researchers to employ chemokines as potential vaccine adjuvants. (mdpi.com)
  • An important paralog of this gene is CCL7 . (genecards.org)
  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. (creativebiomart.net)
  • Gene expression profiling revealed in M27 colIV cells significant increases in the expression of chemokines CCL5 (5.7-fold) and CCL7 (2.6-fold) relative to wild-type cells, and this was validated by qPCR and western blotting. (diva-portal.org)
  • Gene expression profiling studies have shown that intratumoral expression of chemokines, indeed, correlate with T-cell infiltration ( 13 ). (aacrjournals.org)
  • CCR1 is a chemokine receptor that responds to a large number of CC chemokines including CCL3 (MIP-1alpha), CCL5 (RANTES), CCL7 (MCP-3), CCL9 (MIP-1gamma), CCL15 (MIP1 delta), CCL23 (MIP-3), and with low affinity to CCL4 (MIP-1 beta) and CCL8 (MCP-2). (springer.com)
  • Similarly, in human colon carcinoma KM12C and KM12SM cells with divergent liver-colonizing potentials, CCL7 and CCL5 production correlated with type IV collagen expression and the metastatic phenotype. (diva-portal.org)
  • CCL7 silencing by short hairpin RNA (shRNA) reduced experimental liver metastasis in both cell types, whereas CCL5 silencing reduced metastasis of M27 colIV cells, implicating these cytokines in metastatic expansion in the liver. (diva-portal.org)
  • Subsequent functional analyses implicated both MEK/ERK and PI3K signaling upstream of CCL7 upregulation and identified CCL7 (but not CCL5) as a critical migration/invasion factor, acting via the chemokine receptor CCR3. (diva-portal.org)
  • Chemokine CCL5 was identified as a regulator of the T-cell immune response in the liver. (diva-portal.org)
  • Moreover, in clinical specimens of colon cancer liver metastases analyzed by immunohistochemistry, CCL5 and CCL7 levels paralleled those of collagen IV. (diva-portal.org)
  • The results identify the chemokines CCL5 and CCL7 as type IV collagen-regulated genes that promote liver metastasis by distinct and complementary mechanisms. (diva-portal.org)
  • The RayBio human chemokine antibody array revealed that CAFs secret higher levels of CCL2, CCL5, CCL7 and CXCL16 than peri-tumor fibroblasts. (selleckchem.com)
  • CCL2 and CCL5 increase the migration but not the invasion of HCC cells, while CCL7 and CXCL16 promote both migration and invasion of HCC cells. (selleckchem.com)
  • Moreover, CCL2 and CCL5 stimulate the activation of the hedgehog (Hh) pathway, while CCL7 and CXCL16 enhance the activity of the transforming growth factor-β (TGF-β) pathway in HCC cells. (selleckchem.com)
  • In summary, CAF-secreted CCL2, CCL5, CCL7 and CXCL16 promote HCC metastasis through the coordinate activation of Hh and TGF-β pathways in HCC cells. (selleckchem.com)
  • The recombinant human CCL7 consisting of 87 amino acids and has a calculated molecular mass of 10.5 kDa. (antikoerper-online.de)
  • The ELISA Kit is designed to detect native, not recombinant, CCL7. (mybiosource.com)
  • For example, in addition to chemotaxis, chemokines modulate lymphocyte development, priming and effector function [ 2 ] and play a critical role in immune surveillance. (mdpi.com)
  • In addition to being known for mediating chemotaxis, chemokines are all approximately 8-10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikipedia.org)
  • Chemokines are a class of cytokines that induce chemotaxis (migration) of target cells. (biolegend.com)
  • In contrast, the combination of two CC chemokines (CCL2 plus CCL7) or two CXC chemokines (CXCL8 plus CXCL12) did not provide synergy in monocyte chemotaxis. (aspetjournals.org)
  • There are currently no images for CCL7/MCP-3/MARC Antibody (IC282N). (novusbio.com)
  • This CCL7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the Central region of human CCL7. (lsbio.com)
  • The ELISA analytical biochemical technique of the MBS701687 kit is based on CCL7 antibody-CCL7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CCL7 antigen targets in samples. (mybiosource.com)
  • Human peripheral blood mononuclear cells (PBMCs), either left unstimulated (left images) or stimulated with LPS for 2 hours followed by an incubation with brefeldin A for 22 hours, were fixed, permeabilized, and stained with Anti-CCL7 (MCP-3) antibodies. (miltenyibiotec.com)
  • Using antibodies to study cytokines and chemokines has given us a far greater understanding into signaling pathways. (prosci-inc.com)
  • Our cytokine and chemokine antibodies are quality controlled and tested in the application such as western blotting, ELISA, IF, IHC, and ICC. (prosci-inc.com)
  • The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. (google.com)
  • It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine. (google.com)
  • This invention relates to antibodies or the use of antibodies directed against certain chemokines. (google.com)
  • The neutralizing antibodies of chemokines notably attenuate the effect of CAFs on HCC metastasis and compromised the activation of Hh and TGF-β pathways in HCC cells. (selleckchem.com)
  • Recent discoveries in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing recruitment of antigen presenting cells (APCs) and effector cells to appropriate anatomical sites. (mdpi.com)
  • Some chemokines control cells of the immune system during processes of immune surveillance, such as directing lymphocytes to the lymph nodes so they can screen for invasion of pathogens by interacting with antigen-presenting cells residing in these tissues. (wikipedia.org)
  • This functionally defined receptor subfamily is currently thought to be comprised of three members: D6, DARC (Duffy antigen receptor for chemokines), and CCX-CKR (ChemoCentryx chemokine receptor) (for review see references 10 , 11 ). (rupress.org)
  • Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks. (peprotech.com)
  • The major role of chemokines is to act as a chemoattractant to guide the migration of cells. (wikipedia.org)
  • Here, we discuss recent views on the role of chemokines in controlling tissue localisation of human memory T cells under steady state (non-inflamed) conditions. (bmj.com)
  • Surprisingly, Abs to CCL7 and CXCL10 also decreased neutrophil recruitment by 63 and 72%, respectively. (jimmunol.org)
  • Once at the site of injury, immune cells can react by releasing additional cytokines and chemokines, bringing more cells into the fold. (biolegend.com)
  • Cytokines and chemokines are the primary form of signaling between a wide variety of cells. (prosci-inc.com)
  • Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells. (nih.gov)
  • The scientists demonstrated that chemokine CCL7 is diffused through the PPAT to the area around the prostate and that it attracts tumor cells that express the CCR3 receptor towards the periprostatic adipose tissue, the gateway to the rest of the body. (eurasiareview.com)
  • 2] A patent (FR1455491 - PCTIB2015054550) called "Inhibition de la chimiokine CCL7 ou de son récepteur CCR3 pour le traitement et le diagnostic du cancer de la prostate [Inhibition of chemokine CCL7 or its CCR3 receptor for the treatment and diagnosis of prostate cancer]" has been filed on this work. (eurasiareview.com)
  • Eotaxin is a CC chemokine that signals through the CCR3 receptor. (peprotech.com)
  • Small volumes of CCL7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
  • The skin phenotype is characterized by acanthosis, hyperkeratosis, the presence of a mixed inflammatory cell infiltrate, and increased cytokine and chemokine expression. (rupress.org)
  • In this study, we established an arterialized mouse non-heart-beating (NHB) liver transplantation model, and compared survival rates, cytokine and chemokine expression, histology, and the results of in vitro co-culture experiments in animals with or without MSC infusion. (springer.com)
  • Due to their function of targeting cells to specific organs, homeostatic chemokines can also be involved in cancer and metastasis. (biolegend.com)
  • It was also reported, that CCL7 can also induce neutrophil migration to the inflammatory site by increasing intracellular Ca2+ flux, which is more typical for the CXC chemokine family members. (wikipedia.org)
  • Moreover, CCL2 and CCL7 synergised with CXCL8 to promote neutrophil migration. (bmj.com)
  • Conclusion This study highlights important inflammatory chemokines involved in regulating neutrophil migration, which may have potential value as therapeutic targets for the treatment of ARDS. (bmj.com)
  • Some chemokines are considered pro- inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection , while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development . (wikipedia.org)
  • A major rol of chemokines is to act as chemoattractants in guiding migration of cells. (wikipathways.org)
  • Thus, quaternary structure of chemokines and their interaction with GAGs may significantly contribute to the localization of leukocytes beyond migration patterns defined by chemokine receptor interactions. (pnas.org)
  • However, chemokines control the direction of cell migration and provide a trigger for cell activation. (pnas.org)
  • CCL7 is expressed in many types of cells, including stromal cells, keratinocytes, airway smooth muscle cells, parenchymal cells, fibroblasts and leukocytes and also in tumor cells. (wikipedia.org)
  • Treatment of tumor-bearing mice with chemotherapy induced intratumoral expression of these chemokines and favored T-cell infiltration into cutaneous tumors. (aacrjournals.org)
  • In patients with melanoma, these chemokines were also upregulated in chemotherapy-sensitive lesions following chemotherapy, and correlated with T-cell infiltration, tumor control, and patient survival. (aacrjournals.org)
  • T-cell recruitment to the tumor is one of the potential rate-limiting steps in immunotherapy, and thus, intratumoral chemokines are likely to have a major impact ( 11, 12 ). (aacrjournals.org)
  • Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. (springer.com)
  • Gerard C, Frossard JL, Bhatia M, Saluja A, Gerard NP, Lu B, Steer M. Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. (springer.com)
  • Khan IA, Murphy PM, Casciotti L, Schwartzman JD, Collins J, Gao JL, Yeaman GR. Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection. (springer.com)
  • CCL7 can exist in four different glycotypes with a molecular weight 11, 13, 17 and 18 kDa in COS cells. (wikipedia.org)
  • Gentaur Molecular :Biovend \ CCL7 (MCP-3) (Biotinylated) Rec. (antibody-antibodies.com)
  • Chemokines are a family of small molecular weight cytokines, which are involved in leukocytes stimulation and chemotactic gradient determining. (hindawi.com)
  • All chemokines are small, with a molecular mass of between 8 and 10 kDa . (wikidoc.org)
  • The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. (peprotech.com)
  • CCL7 can also interact with cell surface glycosaminoglycans (GAGs) present on all animal cell surfaces. (wikipedia.org)
  • It has been suggested that an important component of this process is the formation of a haptotactic gradient by immobilization of chemokines on cell surface glycosaminoglycans (GAGs). (pnas.org)
  • Use this table to quickly identify the chemokines that bind to each receptor. (biolegend.com)
  • Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice. (peprotech.com)
  • which may be indicative of the limited conservation of some CC chemokine/receptor systems across species. (aspetjournals.org)
  • In contrast to most chemokines, CCL7 exists in a general monomeric form, differing from the dimer formed in a highly concentrated solution. (wikipedia.org)
  • Detects human CCL7/MCP-3/MARC in ELISAs and Western blots. (novusbio.com)
  • This review will focus on recent murine and human studies that use chemokines as therapeutic anti-cancer vaccine adjuvants. (mdpi.com)
  • BAL fluid from patients with ARDS was highly chemotactic for human neutrophils and neutralising either CCL2 or CCL7 attenuated the neutrophil chemotactic response. (bmj.com)
  • The large majority of approximately 50 human chemokines fall into the group of either CXC or CC chemokines. (bmj.com)
  • We found that dacarbazine, temozolomide, and cisplatin induced expression of T-cell-attracting chemokines in several human melanoma cell lines in vitro . (aacrjournals.org)
  • We investigated chemokines attracting T cells into human CRCs, their cellular sources and microenvironmental triggers. (bmj.com)
  • This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2(previously called MCP1). (prospecbio.com)
  • In this article we have combined the "common" name with the systematic nomenclature at the first instance a particular chemokine is mentioned and then used the systematic name in the remainder of the text. (bmj.com)
  • Chemokines are a group of related chemoattractant peptides that are essential regulators of the immune system, both during homeostatic and inflammatory conditions. (mdpi.com)
  • SCH-530,348 SCH530348 has been recently shown to attenuate the neutrophilic inflammatory response to Streptococcus pneumoniae by reducing levels of pro-inflamamtory cytokines such as IL-1β and chemokines CXCL1, CCL2 and CCL7. (wikipedia.org)
  • Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9). (peprotech.com)
  • It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. (bio-rad.com)
  • These data identify the induction of intratumoral expression of chemokines as a novel cell-extrinsic mechanism of action of chemotherapy that results in the recruitment of immune cells with antitumor activity. (aacrjournals.org)
  • The genetically deficient mice in CCL7 have inreased mortality because of decrease in monocytes and neutrophils. (wikipedia.org)
  • To identify these chemokines, three groups of BALB/c mice were exposed to sham air, 0.2 ppm O 3 , or 0.8 ppm O 3 for 6 h. (jimmunol.org)
  • Chemokine production by CRC cells was evaluated in vitro and in vivo, on generation of intraperitoneal or intracecal tumour xenografts in immune-deficient mice. (bmj.com)
  • However, the description of the nonredundant pharmacology of ligands to a given receptor in defined in vitro systems and in the absence of most of the confounding in vivo mechanisms is of prime interest for drug development, which has indeed been hampered by the complexity of the chemokine system. (aspetjournals.org)
  • It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. (creativebiomart.net)
  • The spacing between the first two cysteines determines the type of chemokine. (biolegend.com)
  • Chemokine receptor expression on neutrophils from blood or BAL fluid of patients with ARDS was analysed by flow cytometry. (bmj.com)
  • Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity. (peprotech.com)
  • Chemokine receptor expression on TILs was evaluated by flow cytometry on cell suspensions from digested tissues. (bmj.com)
  • CCL7 is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils. (klamar-reagent.com)
  • thus, it is not surprising that chemokines are also able to bind linear sulfated GAGs such as heparin and heparan sulfate. (pnas.org)
  • All chemokines share a typical Greek key structure that is stabilised by disulphide bonds between conserved cysteine residues. (wikidoc.org)
  • This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. (genecards.org)
  • Members of the chemokine family are divided into four groups depending on the location of their first two cysteine residues. (genscript.com)
  • Chemokines have been traditionally divided into four families (CXC, CC, C, and CX3C) based on the patterns of amino-terminal cysteine residues. (pnas.org)