Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
A cell line derived from cultured tumor cells.
A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.
CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.
The classes of BONE MARROW-derived blood cells in the monocytic series (MONOCYTES and their precursors) and granulocytic series (GRANULOCYTES and their precursors).
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
Tumors or cancer of the PROSTATE.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS.
The study of MAGNETIC PHENOMENA.
Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.
Short thick veins which return blood from the kidneys to the vena cava.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Tumors or cancers of the KIDNEY.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
The formation or presence of a blood clot (THROMBUS) within a vein.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Immunoglobulins produced in response to VIRAL ANTIGENS.
TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).

Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries. (1/4001)

Monocyte chemoattractant protein-1 (MCP-1)/monocyte chemotactic and activating factor (MCAF) has been suggested to promote atherogenesis. The effects of in vivo neutralization of MCP-1 in a rat model were examined in an effort to clarify the role of MCP-1 in the development of neointimal hyperplasia. Competitive polymerase chain reaction analysis revealed maximum MCP-1 mRNA expression at 4 hours after carotid arterial injury. Increased immunoreactivities of MCP-1 were also detected at 2 and 8 hours after injury. Either anti-MCP-1 antibody or nonimmunized goat IgG (10 mg/kg) was then administered every 12 hours to rats that had undergone carotid arterial injury. Treatment with 3 consecutive doses of anti-MCP-1 antibody within 24 hours (experiment 1) and every 12 hours for 5 days (experiment 2) significantly inhibited neointimal hyperplasia at day 14, resulting in a 27.8% reduction of the mean intima/media ratio (P<0.05) in experiment 1 and a 43.6% reduction (P<0.01) in experiment 2. This effect was still apparent at day 56 (55.6% inhibition; P<0.05). The number of vascular smooth muscle cells in the neointima at day 4 was significantly reduced by anti-MCP-1 treatment, demonstrating the important role of MCP-1 in early neointimal lesion formation. However, recombinant MCP-1 did not stimulate chemotaxis of vascular smooth muscle cells in an in vitro migration assay. These results suggest that MCP-1 promotes neointimal hyperplasia in early neointimal lesion formation and that neutralization of MCP-1 before, and immediately after, arterial injury may be effective in preventing restenosis after angioplasty. Further studies are needed to clarify the mechanism underlying the promotion of neointimal hyperplasia by MCP-1.  (+info)

Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes. (2/4001)

We have previously shown that different isolates of Chlamydia pneumoniae display heterogeneity in the in vitro stimulation of chemokines and adhesion molecules from infected human endothelial cells. In the present study, we examined the ability of different isolates of C. pneumoniae to promote transendothelial migration of neutrophils and monocytes. Human umbilical vein endothelial cells (HUVEC) were infected with low (<15)-passage C. pneumoniae isolates A-03, PS-32, and BR-393 and high (>40)-passage isolates BAL-16, TW-183, and T-2634, and levels of neutrophil and monocyte transendothelial migration were determined following 24 h of infection. Compared to mock-infected controls, significant increases in neutrophil migration were observed in response to most C. pneumoniae isolates examined (P < 0.001). Levels of monocyte migration were significantly increased in response to TW-183 and T-2634 (P < 0.001). Serial passage (>40 times) of the three low-passage isolates in HEp-2 cell cultures prior to infection of HUVEC generally resulted in the promotion of higher levels of neutrophil and monocyte transendothelial migration. These findings were compatible with differences observed in the extent of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) stimulation between low- and high-passage A-03, PS-32, and BR-393. As opposed to C. pneumoniae, infection with C. trachomatis L2 caused only a slight increase in neutrophil transendothelial migration, which correlated with the lack of measurable IL-8 levels by this species. However, significant levels of monocyte migration were induced in response to C. trachomatis L2 despite a lack of measurable MCP-1 stimulation. C. trachomatis serovars A and E also failed to induce IL-8 and MCP-1 production in HUVEC. Results from this study indicate that the passage history of C. pneumoniae may play a role in the divergence of stimulatory activities observed among isolates in human endothelial cells. In addition, the differences observed between this organism and C. trachomatis suggest that the upregulation of IL-8 and MCP-1 in endothelial cells may be unique to C. pneumoniae.  (+info)

Luteal regression in the normally cycling rat: apoptosis, monocyte chemoattractant protein-1, and inflammatory cell involvement. (3/4001)

In hypophysectomized rats, prolactin induces regression of the corpora lutea. Luteal regression is accompanied by infiltration of monocytes/macrophages, declines in luteal mass and plasma progestins, and increased staining for monocyte chemoattractant protein-1 (MCP-1). We investigated whether similar events are induced during the estrous cycle, after the proestrous prolactin surge. Rats were killed on proestrus or on estrus, and one ovary was frozen for immunohistochemical detection of MCP-1, monocytes/macrophages (ED1-positive), and differentiated macrophages (ED2-positive) and for in situ detection of apoptotic nuclei. Corpora lutea of the current (proestrus) or preceding (estrus) cycle were dissected from the ovaries of additional rats and frozen for the same analyses and for determination of total protein content. In sections of whole ovaries, intensity and distribution of MCP-1 staining were increased in corpora lutea of multiple ages on estrus as compared to proestrus, as were numbers of differentiated macrophages and apoptotic nuclei per high-power field. Sections of isolated corpora lutea showed these increases on estrus, and the number of monocytes/macrophages per high-power field was also significantly increased. Accompanying these inflammatory/immune events, the corpora lutea on estrus showed decreased weight and total protein per corpus luteum, as compared to corpora lutea on proestrus. These changes are consistent with a proposed role for prolactin in the initiation of luteal apoptosis and of a sequence of inflammatory/immune events that accompany regression of the rat corpus luteum during the normal estrous cycle.  (+info)

Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles. (4/4001)

Particulate wear debris is associated with periprosthetic inflammation and loosening in total joint arthroplasty. We tested the effects of titanium alloy (Ti-alloy) and PMMA particles on monocyte/macrophage expression of the C-C chemokines, monocyte chemoattractant protein-1 (MCP-1), monocyte inflammatory protein-1 alpha (MIP-1alpha), and regulated upon activation normal T expressed and secreted protein (RANTES). Periprosthetic granulomatous tissue was analysed for expression of macrophage chemokines by immunohistochemistry. Chemokine expression in human monocytes/macrophages exposed to Ti-alloy and PMMA particles in vitro was determined by RT-PCR, ELISA and monocyte migration. We observed MCP-1 and MIP-1alpha expression in all tissue samples from failed arthroplasties. Ti-alloy and PMMA particles increased expression of MCP-1 and MIP-1alpha in macrophages in vitro in a dose- and time-dependent manner whereas RANTES was not detected. mRNA signal levels for MCP-1 and MIP-1alpha were also observed in cells after exposure to particles. Monocyte migration was stimulated by culture medium collected from macrophages exposed to Ti-alloy and PMMA particles. Antibodies to MCP-1 and MIP-1alpha inhibited chemotactic activity of the culture medium samples. Release of C-C chemokines by macrophages in response to wear particles may contribute to chronic inflammation at the bone-implant interface in total joint arthroplasty.  (+info)

Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells. (5/4001)

We have recently described a significant correlation between human immunodeficiency virus-1 (HIV-1) RNA replication and monocyte chemotactic protein-1 (MCP-1) levels in the cerebrospinal fluid (CSF) of individuals with the acquired immunodeficiency syndrome (AIDS) with HIV encephalitis (E). Because local macrophages (microglia) are the cells predominantly infected in the brain, we investigated whether in vitro HIV infection affects MCP-1 production in mononuclear phagocytes (MP). MCP-1 secretion and expression were consinstently upregulated over constitutive levels in human monocyte-derived macrophages (MDM) infected with the M-tropic R5 BaL strain of HIV-1. HIV replication was required for this effect, as demonstrated by the absence of chemokine upregulation after infection in the presence of 3'-azido-3'-deoxythimidine (AZT) or cell-exposure to heat-inactivated (triangle up degrees ) virus. MCP-1 induction was not restricted to HIV-1 BaL, but was also observed during productive infection of MDM with two primary isolates differing for entry coreceptor usage and of U937 cells with the X4 HIV-1 MN strain. Based on the observation that exogenous HIV-1 Tat induced MCP-1 expression in astrocytes, we also investigated its role in MDM and U937 cells. Exogenous Tat induced MCP-1 production from MDM in a concentration-dependent manner, however, it was not effective on uninfected U937 cells or on the chronically infected U937-derived cell line U1. Transfection of Tat-expressing plasmids moderately activated HIV expression in U1 cells, but failed to induce MCP-1 expression in this cell line or in uninfected U937 cells. HIV replication-dependent expression of MCP-1 in MP may be of particular relevance for the pathogenesis of HIV infection in nonlymphoid organs such as the brain.  (+info)

Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression. (6/4001)

To delineate the mechanisms that facilitate leukocyte migration into the cystic fibrosis (CF) lung, expression of chemokines, including interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and RANTES, was compared between CF and non-CF airway epithelia. The findings presented herein demonstrate that, under either basal conditions or tumor necrosis factor-alpha (TNF-alpha)- and/or interferon-gamma (IFN-gamma)-stimulated conditions, a consistent pattern of differences in the secretion of IL-8 and MCP-1 between CF and non-CF epithelial cells was not observed. In contrast, CF epithelial cells expressed no detectable RANTES protein or mRNA under basal conditions or when stimulated with TNF-alpha and/or IFN-gamma (P +info)

Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice. (7/4001)

Several lines of evidence show the importance of angiotensin II (AII) in renal injuries, especially when hemodynamic abnormalities are involved. To elucidate the role of AII in immune-mediated renal injury, we studied anti-glomerular basement membrane (GBM) nephritis in AII type 1a receptor (AT1a)-deficient homozygous (AT1a-/-) and wild-type (AT1a+/+) mice. A transient activation of the renin-angiotensin system (RAS) was observed in both groups of mice at around day 1. A renal expression of monocyte chemoattractant protein-1 (MCP-1) was transiently induced at six hours in both groups, which was then downregulated at day 1. In the AT1a+/+ mice, after RAS activation, the glomerular expression of MCP-1 was exacerbated at days 7 and 14. Thereafter, severe proteinuria developed, and the renal expressions of transforming growth factor-beta1 (TGF-beta1) and collagen type I increased, resulting in severe glomerulosclerosis and interstitial fibrosis. In contrast, glomerular expression of MCP-1, proteinuria, and tissue damage were markedly ameliorated in the AT1a-/- mice. Because this amelioration is likely due to the lack of AT1a, we can conclude that AII action, mediated by AT1a, plays a pathogenic role in anti-GBM nephritis, in which AII may contribute to the exacerbation of glomerular MCP-1 expression. These results suggest the involvement of AII in immune-mediated renal injuries.  (+info)

MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. (8/4001)

The earliest recognizable atherosclerotic lesions are fatty streaks composed of lipid-laden macrophages (foam cells). Circulating monocytes are the precursors of these foam cells, but the molecular mechanisms that govern macrophage trafficking through the vessel wall are poorly understood. Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. Recent studies in hypercholesterolemic mice lacking apo E or the low-density lipoprotein receptor have suggested a role for MCP-1 in monocyte recruitment to early atherosclerotic lesions. To determine if MCP-1 is critically involved in atherogenesis in the setting of elevated physiological plasma cholesterol levels, we deleted the MCP-1 gene in transgenic mice expressing human apo B. Here we report that the absence of MCP-1 provides dramatic protection from macrophage recruitment and atherosclerotic lesion formation in apo B transgenic mice, without altering lipoprotein metabolism. Taken together with the results of earlier studies, these data provide compelling evidence that MCP-1 plays a critical role in the initiation of atherosclerosis.  (+info)

TY - JOUR. T1 - Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction. AU - Hayashidani, Shunji. AU - Tsutsui, Hiroyuki. AU - Shiomi, Tetsuya. AU - Ikeuchi, Masaki. AU - Matsusaka, Hidenori. AU - Suematsu, Nobuhiro. AU - Wen, Jing. AU - Egashira, Kensuke. AU - Takeshita, Akira. PY - 2003/10/28. Y1 - 2003/10/28. N2 - Background - Increased expression of monocyte chemoattractant protein-1 (MCP-1) has recently been described in clinical and experimental failing heart. However, its pathophysiological significance in heart failure remains obscure. We thus determined whether MCP-1 is increased in post-myocardial infarction (MI) hearts and its blockade can attenuate the development of left ventricular (LV) remodeling and failure. Methods and Results - Anterior MI was produced in mice by ligating the left coronary artery. After 4 weeks, MI mice exerted LV dilatation and contractile dysfunction in association with ...
TY - JOUR. T1 - Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1. AU - Merhi, Zaher. AU - Thornton, Kimberley. AU - Bonney, Elizabeth. AU - Cipolla, Marilyn J.. AU - Charron, Maureen J.. AU - Buyuk, Erkan. PY - 2016/2/15. Y1 - 2016/2/15. N2 - Purpose: The objective of this study was to test the hypothesis that ovarian kisspeptin (kiss1) and its receptor (kiss1r) expression are affected by age, obesity, and the age- and obesity-related chemokine monocyte chemoattractant protein-1 (MCP-1). Methods: Ovaries from reproductive-aged and older C57BL/6J mice fed normal chow (NC) or high-fat (HF) diet, ovaries from age-matched young MCP-1 knockout and young control mice on NC, and finally, cumulus and mural granulosa cells (GCs) from women who underwent in vitro fertilization (IVF) were collected. Kiss1, kiss1r, anti-Mullerian hormone (AMH), and AMH receptor (AMHR-II) messenger RNA (mRNA) expression levels were quantified using real-time polymerase chain reaction ...
TY - JOUR. T1 - Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients. AU - Chung, Hye Kyung. AU - Kim, Oh Yoen. AU - Lee, Hyeran. AU - Do, Hyun Joo. AU - Kim, Young Soon. AU - Oh, Jaewon. AU - Kang, Seok Min. AU - Shin, Min-Jeong. PY - 2011/7/1. Y1 - 2011/7/1. N2 - This study aimed to axamine the association of dietary vitamin intakes with plasma pro-inflammatory cytokine levels in Korean heart failure patients. Stable outpatients with heart failure were recruited and finally 91 patients were included. Dietary intakes were estimated by a developed semi-quantitative food frequency questionnaire. The simultaneous measurement of 17 cytokines was performed along with analysis of plasma C-reactive protein. Plasma C-reactive protein levels significantly correlated with dietary intakes of vitamin C (r = -0.30, p,0.005), β-carotene (r = -0.23, p,0.05), and folate (r = -0.31, p,0.005). However, these associations were no ...
Results Compared with those in control group (AA:17.81%, GA:49.31%, GG:32.88%, G allele: 57.53%), respectively, no significant differences were revealed in frequencies of any genotypes and G allele of the MCP-1 gene -2518G/A in ACS group (AA: 16.27%, GA: 51.20%, GG: 32.53%, G allele:58.13%), AMI group (AA: 11.70%, GA: 51.06%, GG: 37.24%, G allele: 62.77%) and UAP group (AA: 22.22%, GA: 51.39%, GG: 26.39%, G allele: 52.08%) (all p values,0.05). Multivariate including age, gender, plasma lipids level, history of diabetes mellitus, hypertension and smoking logistic regression analysis showed that MCP-1 gene -2518 G/A polymorphism was not associated with an increased risk of ACS, AMI and UAP (all p values,0.05). The serum MCP-1 level (M/IQR) was significantly higher in ACS group (157.44/241.82 pg/ml), AMI group (157.44/245.67 pg/ml) and UAP group (157.14/231.95 pg/ml) than that of in the control group (80.96/89.17 pg/ml) (all p values ,0.01). No significant difference was found in the serum MCP-1 ...
Intestinal epithelial cells are the initial sites of host response to Clostridium difficile infection and can play a role in signaling the influx of inflammatory cells. To further explore this role, the regulated expression and polarized secretion of CXC and CC chemokines by human intestinal epithelial cells were investigated. An expression of the CXC chemokines, including IL-8 and growth-related oncogene (GRO)-alpha, and the CC chemokine monocyte chemoattractant protein (MCP)-1 from HT-29 cells increased in the 1-6 hr following C. difficile toxin A stimulation, assessed by quantitative RT-PCR. In contrast, the expression of neutrophil activating protein-78 (ENA-78) was delayed for 18 hr. The up-regulated mRNA expression of chemokines was paralleled by the increase of protein levels. However, the expression of macrophage inflammatory protein (MIP)-1alpha, RANTES (regulated on activation normal T cells expressed and secreted), and interferon-gamma-inducible protein-10 (IP-10) was not changed in ...
Invitrogen™ eBioscience™ Human MCP-1 Platinum ELISA Kit 96 tests Invitrogen™ eBioscience™ Human MCP-1 Platinum ELISA Kit MCP-1 ELISA...
AlphaLISA no-wash assay kit for detection and quantitation of Human Monocyte Chemoattractant Protein-1 (CCL2 / MCP1) in serum, buffered solution or cell culture medium.
Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol into account. The study was a cross-sectional assessment of patients at admission to a specialized psychiatric center in Norway. A total of 128 patients were included. Information was gathered using the self-administered questionnaires Beck Depression Inventory-II (BDI-II) and the Alcohol Use Disorders Identification Test (AUDIT), in addition to clinical interviews recording childhood or adult life trauma. Serum levels of the cytokines Interleukin-1β (IL-1β), Interleukin-1 Receptor Antagonist (IL-1RA), Tumor Necrosis Factor-α (TNF-α) and the chemokine Monocyte Chemoattractant Protein-1 (MCP-1) were assessed. A Luminex bead
A study published in this issue reveals an important new genetic link to pulmonary tuberculosis in adults (21). In this study, Flores-Villanueva et al. identify a polymorphism in the promoter region of the gene encoding the chemokine monocyte chemoattractant protein-1 (MCP-1) that confers susceptibility to pulmonary tuberculosis in Mexican adults. This polymorphism is characterized by an adenine (A) to guanine (G) change at position −2518 of the MCP1 promoter. The results of the study are reported in terms of odds ratio (OR), which is a valid estimate of the relative risk (the risk of developing tuberculosis according to genotype) when the disease prevalence is low (typically ,10%). The ORs of tuberculosis among individuals with AG and GG versus AA genotypes were estimated at 2.3 and 5.4, respectively. This means that individuals homozygous for the G allele were approximately five times more likely to develop tuberculosis than those homozygous for the A allele. The GG genotype is associated ...
Mouse anti Human MCP-3 antibody, clone h.mcp.3 recognizes human C-C motif chemokine 7, also known as Monocyte chemoattractant protein 3, M
Chemokine (C-C motif) ligand 8--also known as monocyte chemoattractant protein 2 (MCP-2), HC14, SCYA8, or SCYA10--is a protein encoded by the CCL8 gene. The precursor protein (109 amino acids) is cleaved to produce mature CCL8 (75 amino acids). CCL8 activates many different immune cells, including mast cells, eosinophils, and basophils (implicated in allergic responses), and monocytes, T cells, and NK cells (involved in the inflammatory response). CCL8 acts through binding to several different cell surface chemokine receptors, including CCR1, CCR2B, and CCR5 (one of the major co-receptors for HIV-1).. ...
Monocyte chemoattractant protein-1 (MCP-1), formerly termed JE, is a member of the beta-chemokine (C-C chemokine) family and has been shown to be produced by a variety of cell types. Recently, mRNA of JE/MCP-1 was detected in astrocytes during the acute phase of experimental allergic encephalomyelitis (EAE). In addition, supernatants collected from human cultured astrocytes have recently been found to be chemotactic for monocytes. However, chemokine production and function in glial cells has not been fully examined. Using a sandwich ELISA assay, we have now quantitated MCP-1 levels and assessed MCP-1 function on murine glial cells. Lipopolysaccharide (LPS), interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induced MCP-1 secretion by astrocytes, but not microglia. In addition, pretreatment with interferon (IFN)-gamma significantly augmented MCP-1 production by either LPS or the above cytokines. In contrast, LPS preferentially induced production of another beta-chemokine, macrophage ...
Monocyte chemoattractant protein-4 (MCP-4) is a CC chemokine implicated in the recruitment of eosinophils, monocytes, and T-lymphocytes in diseases of mucosal inflammation, including asthma. We tested the hypothesis that there is a genetic basis for differences in MCP-4 expression among individuals by evaluating the effects of core promoter variants on MCP-4 expression. We identified two single-nucleotide T-to-C polymorphisms in the MCP-4 core promoter that occur 896 and 887 base pairs preceding the transcription initiation site. The -887 variant alters a consensus binding motif for the transcription factor YY-1. Electrophoretic mobility shift assay demonstrated that YY-1 containing nuclear extracts from tumor necrosis factor alpha-stimulated peripheral blood mononuclear cells had greater avidity for the wild-type (YY-1 motif intact) sequence than for the variant sequence. Increasing doses of a YY-1 expression vector induced significantly greater reporter activity from MCP-4 core promoter ...
Conference Paper: Association of the monocyte chemoattractant protein 1 (MCP-1) promoter polymorphism with tuberculosis in the Hong Kong Chinese ...
Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F. Jr., Martinez-A C.. The chemokines are a growing family of low m.w., 70-to 80-residue proinflammatory cytokines that operate by interacting with G protein-coupled receptors. Chemokines are involved in cell migration and in the activation of specific leukocyte subsets. Using the Mono Mac 1 monocytic cell line, we show that monocyte chemotactic protein 1 (MCP-1) triggers activation of the Janus kinase 2 (JAK2)/STAT3 pathway and CCR2 receptor tyrosine phosphorylation. Both Ca2+ mobilization and cell migration are blocked in Mono Mac 1 cells by tyrphostin B42, a specific JAK2 kinase inhibitor. Within seconds of MCP-1 activation, JAK2 phosphorylates CCR2 at the Tyr139 position and promotes JAK2/STAT3 complex association to the receptor. This MCP-1-initiated phosphorylation and association to JAK2 is also observed in CCR2B-transfected HEK293 cells. In contrast, when a CCR2B Tyr139Phe mutant is ...
Ohta, M., Kitadai, Y., Tanaka, S., Yoshihara, M., Yasui, W., Mukaida, N., Haruma, K. and Chayama, K. (2002), Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. Int. J. Cancer, 102: 220-224. doi: 10.1002/ijc.10705 ...
This study aimed to investigate the associations of Interleukin-17 (IL-17) and monocyte chemoattractant protein-1 (MCP-1) with vascular lesions in pat..
Monocyte chemoattractant protein-1 -2518G/A gene polymorphism and the risk of nephropathy in type 2 diabetes mellitus among Asians: a meta-analysis | Mao, Song; Huang, Songming | download | BookSC. Download books for free. Find books
Fish oils (FOs) have antiinflammatory effects and lower serum triglycerides. This study examined adipose and muscle inflammatory markers after treatment of humans with FOs and measured the effects of ω-3 fatty acids on adipocytes and macrophages in vitro. Insulin-resistant, nondiabetic subjects were treated with Omega-3-Acid Ethyl Esters (4 g/day) or placebo for 12 weeks. Plasma macrophage chemoattractant protein 1 (MCP-1) levels were reduced by FO, but the levels of other cytokines were unchanged. The adipose (but not muscle) of FO-treated subjects demonstrated a decrease in macrophages, a decrease in MCP-1, and an increase in capillaries, and subjects with the most macrophages demonstrated the greatest response to treatment. Adipose and muscle ω-3 fatty acid content increased after treatment; however, there was no change in insulin sensitivity or adiponectin. In vitro, M1-polarized macrophages expressed high levels of MCP-1. The addition of ω-3 fatty acids reduced MCP-1 expression with no ...
MCP-1 (5); Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting. Bulk and Prepack available at Sigmaaldrich.com.
Monoclonal Anti-Monocyte Chemotactic Protein-2 antibody produced in mouse is suitable for indirect ELISA, western blot, neutralization
In the present study, we showed that gene transfer of rat MCP-1 to the vascular wall of the carotid artery induced early histological changes associated with atherosclerosis in rabbits treated with a high cholesterol diet. Gene transfer of MCP-1 alone in the absence of hypercholesterolemia failed to induce the vascular lesion. The histological changes associated with atherosclerosis were not detected in carotid arteries when rabbits were treated with a high cholesterol diet for 4 weeks in the absence of MCP-1 gene transfer. The vascular lesion developed by MCP-1 gene transfer under hypercholesterolemia is in accordance with fatty streaks or intimal xanthoma, which occurs in the early phase of atherosclerosis.14,15. An increasing amount of evidence has demonstrated the important role of MCP-1 in the initiation and development of atherosclerosis.16,17 In addition to the potent chemoattractant action for circulating monocytes, MCP-1 exerts various effects on monocytes/macrophages. MCP-1 induces the ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009 ...
The importance of MCP-1 for mononuclear cell recruitment has been shown in various animal models of disease (9-13). Our results confirm that peritoneal MΦ recruitment after thioglycollate is significantly reduced in MCP-1 KO mice, and we demonstrate for the first time the importance of this chemokine for NK cell and MΦ recruitment during acute humoral rejection. By performing the transplant study in a xenogeneic model, it was possible to differentiate between MCP-1 made by donor tissue from that made by recipient. Only the former was associated with infiltration into rejecting hearts.. Results from complimentary but distinct experimental approaches, using either WT or PAR-1 KO hearts transplanted into defibinogenated rats or CD31-Hir-Tg hearts transplanted into unmanipulated rats, showed that PAR-1 activation on donor cells was necessary to generate sufficient quantities of donor MCP-1 to promote leukocyte infiltration. Similarly, MCP-1 generation and MΦ recruitment into the inflamed ...
The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection ...
Bachem offers H-5826 Monocyte Chemotactic Protein-1 (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
Product Name: Mouse mAb anti- human MCP-1 / MCAF, Clone S382Collection: AntibodySub Category: Monoclonal AntibodyImmunogen: Purified recombinant human MCP-1Host
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1DOM: Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer.
By Northern analysis, freshly isolated monocytes contained no detectable mRNA for monocyte chemotactic protein-1 (MCP-1). However, after 4 hours of incubation at 37 degrees C, MCP-1 mRNA was clearly induced in the monocytes and was found to be highly dependent and directly proportional to the monocyte density. The level of MCP-1 mRNA continued to increase, reaching a peak after 22 hours of incubation. After 3 days in culture, MCP-1 mRNA levels had declined substantially and after 8 days were undetectable in the monocytes/macrophages. The amount of MCP-1 protein secreted correlated with the density-dependent increase in MCP-1 message. We hypothesize that the migration of monocytes into inflammatory lesions may be amplified by the density and time-dependent induction of MCP-1. ...
Monocyte Chemoattractant Protein 3 (MCP-3), also called CCL7, is produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1, CCR2, and CCR3. CCL7 chemoattracts monocytes and can regulate macrophage function. Alternate Names: CCL7, MARC
Mouse C-C Motif Chemokine 2 / Monocyte Chemoattractant Protein 1 (CCL2/MCP1) standard, for use in running standard curves in AlphaLISA no-wash detection assays.
|98% Pure active Recombinant Human MCP-1 (MCAF), which plays an important role in the inflammatory response of blood monocytes and tissue microphages.
BioMarker Inflammation. Elevated levels of MCP-1 is seen in diseases such as atherosclerosis, nephropathy, rheumatoid arthritis, multiple sclerosis and NASH.
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
Product Name: Mouse mAb anti- human MCP-1 / MCAF, Tracer (HRP Labeled), Clone S101Collection: AntibodySub Category: Matched Antibody PairsImmunogen: Purified
Monocyte chemotactic protein-1 (MCP-1) also known as monocyte chemotactic and activating factor (MCAF) was identified based on its ability to chemoattract monocytes. Subsequently, MCP-1 has also been found to regulate adhesion molecule expression and cytokine production in monocytes. MCP-1 is identi
Reaktivität: Meerschweinchen - Probe: Serum, Cell Culture Supernatant. | Chemokine (C-C Motif) Ligand 8 (CCL8) ELISA Kit (ABIN628807).
Recombinant Chemokine (C-C Motif) Ligand 17 (CCL17) 蛋白. 宿主: 人. 宿主: 大肠杆菌(E. Coli). 产品编号 ABIN2469118.
Monocyte Chemotactic Protein-3 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids.
CCL7/MCP-3/MARC Proteins available through Novus Biologicals. Browse our CCL7/MCP-3/MARC Protein catalog backed by our Guarantee+.
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Ccl2 - Ccl2 (untagged) - Mouse chemokine (C-C motif) ligand 2 (Ccl2), (10ug) available for purchase from OriGene - Your Gene Company.
Looking for online definition of Monocyte Chemoattractant Protein 1 in the Medical Dictionary? Monocyte Chemoattractant Protein 1 explanation free. What is Monocyte Chemoattractant Protein 1? Meaning of Monocyte Chemoattractant Protein 1 medical term. What does Monocyte Chemoattractant Protein 1 mean?
Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown aetiology characterized by accumulations of lipoproteinaceous material within the alveoli. The alveolar macrophages become increasingly foamy, and are thought to have a role in the pathogenesis of PAP. However, the mechanisms of macrophage recruitment are unclear. In the bronchoalveolar lavage fluid (BALF) of four patients with PAP and 20 normal control subjects, the following were examined: the monocyte chemotactic activity due to the chemokine monocyte chemoattractant protein (MCP)-1 with the use of a chemotactic chamber assay, the levels of MCP-1 by enzyme-linked immunosorbent assay, and the MCP-1 expression on lavage cells by immunocytochemistry and in situ hybridization. The monocyte chemotactic activity in the BALF of the PAP patients was markedly elevated, and the activity was completely absorbed by treatment with anti-MCP-1. The MCP-1 levels in the BALF were surprisingly high in the PAP group (25,100+/-472 pg x mL(-1)), ...
PURPOSE: To characterize the reactions of retinal glial cells (astrocytes and Müller cells) to retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP-/-Vim-/-) and to determine the role of glial cells in retinal detachment (RD)-induced photoreceptor degeneration. METHODS: RD was induced by subretinal injection of sodium hyaluronate in adult wild-type (WT) and GFAP-/-Vim-/- mice. Astroglial reaction and subsequent monocyte recruitment were quantified by measuring extracellular signal-regulated kinase (Erk) and c-fos activation and the level of expression of chemokine monocyte chemoattractant protein (MCP)-1 and by counting monocytes/microglia in the detached retinas. Immunohistochemistry, immunoblotting, real-time quantitative polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA) were used. RD-induced photoreceptor degeneration was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) and measurement of outer ...
TY - JOUR. T1 - Dobutamine inhibits monocyte chemoattractant protein-1 production and chemotaxis in human monocytes. AU - Li, Chi Yuan. AU - Tsai, Chien Sung. AU - Chueh, Sheau Huei. AU - Hsu, Ping Ching. AU - Wang, Jia Yi. AU - Wong, Chih Shung. AU - Ho, Shung Tai. PY - 2003/7/1. Y1 - 2003/7/1. N2 - It has been reported that, in patients with acute myocardial infarction or congestive heart failure, monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of inflammatory responses and that the level of MCP-1 is correlated with the severity of the disease. We conducted this study to investigate the effects of dobutamine and dopamine on lipopolysaccharide (LPS)-induced MCP-1 production in human monocytic THP-1 cells. Monocytes were incubated in vitro with LPS for 16 h at 37°C in the presence or absence of dobutamine or dopamine. Enzyme-linked immunosorbent assay was used to examine the effect of dobutamine on MCP-1 synthesis, with the MCP-1 messenger RNA expression ...
Chemokine (C-C motif) ligand 8--also known as monocyte chemoattractant protein 2 (MCP-2), HC14, SCYA8, or SCYA10--is a protein encoded by the CCL8 gene. The precursor protein (109 amino acids) is cleaved to produce mature CCL8 (75 amino acids). CCL8 activates many different immune cells, including mast cells, eosinophils, and basophils (implicated in allergic responses), and monocytes, T cells, and NK cells (involved in the inflammatory response). CCL8 acts through binding to several different cell surface chemokine receptors, including CCR1, CCR2B, and CCR5 (one of the major co-receptors for HIV-1).. ...
Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines. CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. Activity of this chemokine has been implicated in allergic reactions such as asthma. CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α. Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613-5626 Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40. Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a ...
Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine that attracts monocytes and T lymphocytes in vitro; however, its in vivo functions are poorly understood. To address this question, we constructed transgenic mice expressing MCP-1 controlled by an insulin promoter. These mice developed a chronic insulitic infiltrate composed of F4/80+ monocytes with minor populations of CD4+, CD8+, and B220+ cells. Despite persistent transgene expression, the insulitis never progressed, and blood glucose levels remained normal. Thus, MCP-1 alone is sufficient to elicit a monocytic infiltrate, but not to activate elicited cells. These results differ from those obtained with another transgenic model using the mouse mammary tumor virus long terminal repeat, in which mice expressed substantial MCP-1 in several organs but had no infiltrates. However, mice expressing both transgenes had minimal insulitis, indicating that high systemic levels of MCP-1 prevented monocytes from responding to local MCP-1. Thus, ...
Microglial cells release monocyte chemoattractant protein-1 (MCP-1) which amplifies the inflammation process by promoting recruitment of macrophages and microglia to inflammatory sites in several neurological diseases. In the present study, dexamethasone (Dex), an anti-inflammatory and immunosuppressive drug has been shown to suppress the mRNA and protein expression of MCP-1 in activated microglia resulting in inhibition of microglial migration. This has been further confirmed by the chemotaxis assay which showed that Dex or MCP-1 neutralization with its antibody inhibits the microglial recruitment towards the conditioned medium of lipopolysaccharide (LPS)-treated microglial culture. This study also revealed that the down-regulation of the MCP-1 mRNA expression by Dex in activated microglial cells was mediated via mitogen-activated protein kinase (MAPK) pathways. It has been demonstrated that Dex inhibited the phosphorylation of Jun N-terminal kinase (JNK) and p38 MAP kinases as well as c-jun, ...
Abbkine Scientific has officially announced the release of its EliKine™ Human CCL2 ELISA Kit. The product also is known as the Human MCP1 ELISA Kit which is unique for its high sensitivity and excellent specificity.. The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. Other alternative names include MCP-1, HC11, MCAF, HSMCR30, SMC-CF, GDCF-2, SCYA2, monocyte chemoattractant protein-1, monocyte secretory protein JE. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Abbkine newly launched EliKine™ Human CCL2/MCP-1 ELISA Kit exerts high sensibility and specificity for the quantification of Human CCL2/MCP-1 in various samples to CCL2 level determination.. The Human MCP1 ELISA Kit comes with different features and benefits that stand it out from its ...
Abbkine Scientific has officially announced the release of its EliKine™ Human CCL2 ELISA Kit. The product also is known as the Human MCP1 ELISA Kit which is unique for its high sensitivity and excellent specificity.. The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. Other alternative names include MCP-1, HC11, MCAF, HSMCR30, SMC-CF, GDCF-2, SCYA2, monocyte chemoattractant protein-1, monocyte secretory protein JE. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Abbkine newly launched EliKine™ Human CCL2/MCP-1 ELISA Kit exerts high sensibility and specificity for the quantification of Human CCL2/MCP-1 in various samples to CCL2 level determination.. The Human MCP1 ELISA Kit comes with different features and benefits that stand it out from its ...
Many lines of evidence indicate that MCP-1 recruits monocytes into atherosclerotic lesions and the inflamed peritoneum of mice, where the cells differentiate into macrophages (14-16). The observation that macrophages accumulate in adipose tissue of obese mice and humans (9,10) coupled with the finding that obese humans have elevated MCP-1 expression in their adipose tissue and increased circulating levels of MCP-1 (24,38,39) led to the proposal that MCP-1 might promote macrophage accumulation in adipose tissue and enhance diet-induced obesity (40,41). Studies from two groups using male mice deficient in CCR2 or MCP-1 appeared to support this suggestion (26,27), although the macrophage content of adipose tissue changed only modestly. In contrast, we found no evidence that macrophage accumulation is impaired in adipose tissue of male Mcp1−/− mice fed a high-fat diet for either 10 or 16 weeks. Immunoblot analysis demonstrated higher levels of Mac2, a macrophage-specific protein, in epididymal, ...
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title: Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons, doi: 10.1111/j.1471-4159.2007.04969.x, category: Article
Introduction Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the widely observed phenomenon of increased production of inflammatory mediators that accompany this process, referred to as
For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene. The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1). The gene span is 1,927 bases and the CCL2 gene resides on the Watson (plus) strand. The CCL2 gene has three exons and two introns. The CCL2 protein precursor contains a signal peptide of 23 amino acids. In turn, the mature CCL2 is 76 amino acids long. The CCL2 predicted weight is 11.025 kiloDaltons (kDa). The gene homologous to CCL2 in the mouse is Sig-je. In humans, the levels of CCL2 can vary considerably. In the white people of European descent, the ...
Direct cell-to-cell contact regulates a variety of cellular functions, including cell activation and cytokine production.42 43 45 We attempted to determine whether the interaction between monocytes and endothelial cells induces MCP-1 production from these cell types, because this interaction constantly occurs in recruitment of monocytes and because production of MCP-1 would affect subsequent monocyte transendothelial migration. Our results indicate that migrated monocytes express MCP-1 protein during the process of transmigration. Cocultures of resting monocytes and unstimulated or IL-1-prestimulated endothelial cell monolayers induced an increase in the amounts of soluble MCP-1 secreted into the medium. MCP-1 secreted in supernatants exhibited chemotactic and transendothelial activities for monocytes, and its biological effect was confirmed by the disappearance of the activity in the presence of anti-MCP-1 Ab. Quantification of mRNA levels indicates that augmentation was mediated at the level ...
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Forty patients received add-on etanercept and 15 received DMARDs alone. At the end of one year, etanercept significantly reduced the disease activity score of 28 joints, C-reactive protein, and erythrocyte sedimentation rate. Moreover, etanercept significantly increased the body weight, body mass index (BMI), as well as MCP-1 and NT levels, compared to that in the csDMARD-only group ...
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LEAF™ |!Low Endotoxin, Azide-Free|Purified anti-human MCP-1 Antibody - Monocyte chemotactic protein-1 (MCP-1) also known as monocyte chemotactic and activating factor (MCAF) was identified based on its ability to chemoattract monocytes.
INCB 3284 is an orally active, small molecule antagonist of the chemokine receptor CCR2. CCR2 is a receptor for monocyte chemoattractant proteins such as MCP-1
Publication date: 19 November 2015 Source:Chemistry & Biology, Volume 22, Issue 11 Author(s): Carole Urbach, Nathaniel C. Gordon, Ian Strickland, David Lowne, Cathy Joberty-Candotti, Richard May, Athula Herath, DirkJan Hijnen, Judith L. Thijs, Carla A. Bruijnzeel-Koomen, Ralph R. Minter, Florian Hollfelder, Lutz Jermutus The practical realization of disease modulation by catalytic degradation of a therapeutic target protein suffers from the difficulty to identify candidate proteases, or to engineer their specificity. We identified 23 measurable, specific, and new protease activities using combinatorial screening of 27 human proteases against 24 therapeutic protein targets. We investigate the cleavage of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-13 by matrix metalloproteinases (MMPs) and serine proteases, and demonstrate that cleavage of IL-13 leads to potent inhibition of its biological activity in vitro. MMP-8 degraded human IL-13 most efficiently in vitro and ex vivo in ...
It has been shown that microRNAs (miRNAs) greatly affect the functions of vascular smooth muscle cells (VSMC), but the effects of mRNAs under diabetic conditions remain unclear.Using a model of diabetic db/db mice, we studied the functions of microRNA-135a (miR-135a) during VSMC dysfunction.Compared to control WT mice, miR-135a expression in VSMC was significantly increased while the level of forkhead box O1 (FOXO1) protein decreased significantly. After transfecting miR-135a mimics into VSMC, the expression of FOXO1 was decreased, while cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein-1 (MCP-1) expression levels were increased, thus promoting the interaction between monocytes and WT VSMC ...
Interleukin, T Cells, Il-4, Regulation, Transcription Factor, Chemokines, Mouse, Calcium, Cell, Chemoattractants, Arthritides, Arthritis, Disease, Virus, and Alphavirus
Monocyte Chemotactic Protein-1 Human Recombinant also known as MCAF, produced in E.Coli, is a non-glycosylated, Polypeptide chain containing 76 amino acids.
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The κ statistic provided a measure of interobserver agreement independent of chance on the eligibility of randomised controlled trials. We calculated, for each of the five categories of outcomes, the median event rate and the interquartile range for the control group as well as the effect of the intervention within the category by using the authors reporting of relative risk, odds ratio, or hazard ratio. To ensure independence of observations within categories of importance to patients, we selected only one end point in each category for each composite end point to make these calculations; where a composite included more than one end point in the same category, we selected the end point with the highest event rate in the control group. To estimate the effect of the intervention across trials and within each category, we used random effects meta-analyses with an inverse variance approach. This method is conservative, in that it considers both within study and between study differences in ...
Ways include chemokine CCL2 nitration, which traps T cells in the stroma. Tumor vasculature helps tumors preferentially recruit ...
Tomczak A, Pisabarro MT (April 2011). "Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model". ...
NOX-A12 targets CXCL12 (C-X-C Chemokine Ligand 12), a key chemokine protein. Favorable results were reported in October, 2018 ... NOX-E36 targets MCP-1, also called CCL2. A third Spiegelmer (NOX-H94, lexaptepid pegol) has been in a clinical trial for the ...
5-Oxo-ETE also acts in synergy with two chemokines, CCL2 and CCL8, in stimulating monocyte chemotaxis. The interactions of 5- ... and the two CCL chemokines) in neutrophils and monocytes further suggest that it plays a role in inflammatory responses and ...
L-RNA aptamers have been obtained for the chemokines CCL2 and CXCL12, the complement components C5a and ghrelin. They are ... Proof-of-concept for an anti-CCL2/MCP-1 L-RNA aptamers has recently been demonstrated in diabetic nephropathy patients. They ...
These factors include most particularly chemokines such as monocyte chemotactic protein-1 (CCL2) and monocyte chemotactic ...
"Atypical Chemokine Receptor ACKR2-V41A Has Decreased CCL2 Binding, Scavenging, and Activation, Supporting Sustained ...
November 2015). "Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus ... Power CA, Clemetson JM, Clemetson KJ, Wells TN (August 1995). "Chemokine and chemokine receptor mRNA expression in human ... Griffith JW, Sokol CL, Luster AD (2014). "Chemokines and chemokine receptors: positioning cells for host defense and immunity ... October 1998). "HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine ...
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically ... CCR2 is a CC chemokine receptor. This CCR2 gene is located in the chemokine receptor gene cluster region. Two alternatively ... "Entrez Gene: CCR2 chemokine (C-C motif) receptor 2". El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD ( ... C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the ...
... due to the chemokine CCL2 in rat skin. A similar effect was observed using Lipopolysaccharide (LPS) instead of CCL2 ( ... Peptide 3' is a 12-amino acid linear peptide corresponding to amino acids 51 to 62 of mature human chemokine CCL2. It is formed ... When the 12-amino acid sequence of 'peptide 3'/CCL2 is aligned with the sequences of the other chemokines CCL3, CXCL8 and ... Ala4 in CCL2 is also present in CCL3 but the corresponding residue is Leu in CXCL8 and Ile in CXCL12. Inclusion of Leu at ...
These chemokines include CCL11, CCL2 and CCL12, which are highly localized on mouse and human chromosomes, implicating a ... In healthy aging humans, the plasma and cerebrospinal fluid levels of certain chemokines are elevated. In a mouse model, plasma ... levels of these chemokines correlate with reduced neurogenesis, suggesting that neurogenesis may be modulated by certain global ...
... causes CCL2 secretion to be lowered, and thus the mobility of monocytes to be reduced. This explains part of the ... It was shown that while deoxynivalenol induces the secretion of chemokines, which are also immunorelevant messenger molecules, ... Another important factor influenced by nivalenol is MCP-1/CCL2, this cytokine plays a role in the mobility regulation of ...
... host-derived pro-inflammatory chemokines (e.g. CXCL8, CCL2, CCL3, CCL4, CCL5, CCL11, CXCL10), platelet-activating factor, and ... stimulates their expression the chemokine receptor, CCR5, to inhibit chemokine signaling, enhances their phagocyte activity, ... CMKLR1 (chemokine receptor-like 1), also termed the ChemR23 or E series resolvin receptor (ERV), is expressed on inflammation- ...
June 2013). "Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in ... October 2013). "Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and ... an Anti-Chemokine Ligand 2 [CCL2]) in Participants With Metastatic Castrate-Resistant Prostate Cancer" at ClinicalTrials.gov ... that targets human CC chemokine ligand 2 (CCL2)/monocyte chemoattractant protein (MCP1). Carlumab was under development for use ...
The SASP cytokine CCL2 (MCP1) recruits macrophages to remove cancer cells. Autophagy is upregulated to promote survival. SASP ... Cancer invasiveness is promoted primarily though the actions of the SASP factors metalloproteinase, chemokine, interleukin 6 ( ... Ley, Klaus (2008-10-08). "Faculty Opinions recommendation of Chemokine signaling via the CXCR2 receptor reinforces senescence ...
It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2 from ... November 2018). "Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells". eLife. 7. doi: ...
CCL2 and CCL7. PAR1 is inhibited by Vorapaxar when the molecule binds to a binding pocket between extracellular loop 2 and 3 of ... inflammatory response to Streptococcus pneumoniae by reducing levels of pro-inflammatory cytokines such as IL-1β and chemokines ...
... which induces chemokines such as CCL2 and CCL20 independently of IRF3. STING is also thought to activate the NF-κB ...
Recent work has also determined that genetic and pharmacologic targeting of chemokine (C-C motif) ligand 2 (CCL2) also known as ...
One study showed that monocyte chemotactic protein-1 (chemokine CCL-2) and neutrophil gelatinase associated lipocalin (NGAL) ...
CCL2 (MCP-1) CCL4 (MIP-1) CCL5 (RANTES) CCL17 (TARC) CCL22 (Macrophage-derived chemokine) Chemokines are a group of small ... "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764-8. doi: ... "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 ( ... C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated ...
... and chemokine (C-C motif) ligand 2 (CCL2), all of which are occupied in chemotactic pathways involved in leukocyte recruitment ...
Cantuzumab ravtansine Cathelicidin CC chemokine receptors CCBP2 CCL1 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 ... Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... CR6261 CroFab Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 ...
N-CCL2), which traps T cells in the stroma of colon and prostate cancers. N-CCL2 does attract monocytes. CCL2 nitration ... For instance, inhibiting chemokine receptor type 2 (CCR2), colony-stimulating factor-1 receptor (CSF-1R) and granulocyte ... In a preclinical PDA mouse model, FAP+ CAFs produced the chemokine CXCL12, which is bound by PDA cancer cells. Because FAP+ ... One such mechanism is the release of cell-type specific chemokines. Another is the TME's capacity to posttranslationally alter ...
2008). "Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, ... "Entrez Gene: chemokine (C-C motif) ligand 8". Van Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, ... Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is ... The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans ...
In addition to other chemokines, such as CCL2, CCL3, and CCL4, the presence of CCL1 has been reported in the development of ... Chemokine (C-C motif) ligand 1 (CCL1) is also known as small inducible cytokine A1 and I-309 in humans. CCL1 is a small ... CCL1 is encoded by CCL1 gene which is one of the several chemokine genes clustered on the chromosome 17q11.2-q12 in humans. It ... July 1998). "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells". Journal of Immunology. 161 (2 ...
... encoding protein Zinc finger protein 207 Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, ... C-C motif chemokine ligand 4 like 1 (17q12) DDX52: DExD-box helicase 52 (17q12) ERBB2 loca leukemia viral oncogene homolog 2, ...
It mediates chemokine transcytosis, which leads to apical retention of intact chemokines and more leukocyte migration. Binding ... CCL2 regulated upon activation normal T expressed and secreted (RANTES) - CCL5 melanoma growth stimulatory activity (MSGA-α), ... "Expression of chemokines and chemokine receptors during human renal transplant rejection". Am. J. Kidney Dis. 37 (3): 518-31. ... Duffy Antigen Receptor for Chemokines). The chemokine binding site on the receptor appears to be localised to the amino ...
... particularly chemokines such as CXCL10 and CCL2 (MCP-1) which attract monocytes, natural killer cells, T-lymphocytes, and ... Keratinocytes also modulate the immune system: apart from the above-mentioned antimicrobial peptides and chemokines they are ...
His team demonstrated in 2005 that the chemokine receptor D6 acts as a decoy and scavenger receptor for inflammatory chemokines ... In 1983, his research team has discovered a protein, known as monocyte chemotactic protein - 1 / CCL2, which is part of the ... He was the first to identify monocyte chemotactic protein - 1 / CCL2 in 1983, and PTX3 in 1997. His works revealed the ... Chemokines. 1999. Pharmacology of cytokines. 2000. Gianfranco Bazzoni; Elisabetta Dejana; Alberto Mantovani (2006). Piccin (ed ...
Chemokine. CCL. CCL1 · CCL2 · CCL3 · CCL4 · CCL5 · CCL6 · CCL7 · CCL8 · CCL9 · CCL11 · CCL12 · CCL13 · CCL14 · CCL15 · CCL16 · ...
positive regulation of chemokine (C-X-C motif) ligand 2 production. • positive regulation of JUN kinase activity. • positive ... cancer and ovarian cancer showing prolonged disease stabilization in certain patients via downregulation of IL-6 and CCL2. On ... positive regulation of chemokine production. • cellular extravasation. • negative regulation of lipid storage. • negative ... positive regulation of chemokine biosynthetic process. • epithelial cell proliferation involved in salivary gland morphogenesis ...
Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
Typical inflammatory chemokines include: CCL2, CCL3 and CCL5, CXCL1, CXCL2 and CXCL8. A typical example is CXCL-8, which acts ... C chemokinesEdit. The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... CC chemokinesEdit. The CC chemokine (or β-chemokine) proteins have two adjacent cysteines (amino acids), near their amino ...
C-X-C chemokine receptor activity. • interleukin-8 binding. • G-protein coupled receptor activity. • chemokine receptor ... This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 ... "Chemokine Receptors: CXCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... chemokine-mediated signaling pathway. • interleukin-8-mediated signaling pathway. • neutrophil degranulation. • chemotaxis. ...
chemokine receptor activity. • receptor activity. • protein binding. • C-C chemokine receptor activity. • C-C chemokine binding ... Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[5] CCR6 ... "Entrez Gene: CCR6 chemokine (C-C motif) receptor 6".. *^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, ... "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
CXCL8 (IL-8) forms a chemotactic gradient that directs leukocytes towards site of tissue injury/infection (CCL2 has a similar ... At the same time, chemokines released by macrophages activate the rolling leukocytes and cause surface integrin molecules to ... This is assisted through juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In ... Circulating leukocytes are localised towards the site of injury or infection due to the presence of chemokines. ...
... as well as chemokine and cytokine production, and expression of adhesion molecules such as E-selectin, ICAM-1, and VCAM-1. This ... Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
positive regulation of chemokine biosynthetic process. • regulation of insulin secretion. • extrinsic apoptotic signaling ... Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12 ... Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL18, and CCL23 ...
Inggris)Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks ... "A protective role for ELR+ chemokines during acute viral encephalomyelitis.". Department of Molecular Biology and Biochemistry ...
Some tumors can also produce factors, including M-CSF/CSF1, MCP-1/CCL2 and Angiotensin II, that trigger the amplification and ... Lucas AD, Greaves DR (November 2001). "Atherosclerosis: role of chemokines and macrophages". Expert Reviews in Molecular ... HIV can enter the macrophage through binding of gp120 to CD4 and second membrane receptor, CCR5 (a chemokine receptor). Both ... "CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis". Nature. 475 (7355): 222-5. doi:10.1038/ ...
chemokine activity. • cytokine activity. • heparin binding. • protein binding. • CXCR3 chemokine receptor binding. ... C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T- ... "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11".. *^ a b Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue ... This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a ...
MCP-1/CCL-2, MIP-1α/CCL-3, RANTES/CCL-5 ja interleukiin-8 suurenenud ekspressiooni. ... replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in ...
Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
Chemokine. CCL. *CCL1. *CCL2/MCP1. *CCL3/MIP1α. *CCL4/MIP1β. *CCL5/RANTES ...
Similar to psoriasin, mS100a7a15 recruits leukocytes and induces proinflammatory chemokines as well as cytokines in ... angiogenesis and metastasis through induction of prometastatic and angiogenic factors like CCL2, Cox-2, MMP2, MMP9 and VEGF. ...
The observation that the chemokine CCL2 is potentially responsible for the recruitment of macrophages to atherosclerotic ... A broad-spectrum chemokine inhibitor or BSCI (also termed chemotide or somatotaxin ) is a type of experimental anti- ... Grainger DJ, Reckless J, Fox DJ (2005). "Broad Spectrum Chemokine Inhibitors Related to NR58-3.14.3". Mini-Rev. Med. Chem. 5 (9 ... Kayisli UA, Berkkanoglu M, Zhang L, Kizilay G, Arici A (2007). "The Broad-Spectrum Chemokine Inhibitor NR58-3.14.3 Suppresses ...
CCL2 Gene Structure. Chromosome: chr17 Genbank ID: NM_002982 Orientation: + Length coding sequence : 297 nucleotides. Region. ... Previous Names: "small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)", "chemokine (C-C ...
It is also important to hypothesise about why nucleotides may induce CCL2. In addition to the role of CCL2 as a chemokine for ... to induce CCL2 chemokine production and secretion. We determined the amount of CCL2 secreted at three separate timepoints: 2 ... The CCL2/CCR2 mediated recruitment of monocytes is necessary for fighting infections to microorganisms [1]. This chemokine ... The finding that UTP stimulation of P2Y2 receptors can elicit a similar CCL2 chemokine response to LPS stimulation of TLR4 is a ...
Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a ... sp,P52203,CCL2_CANLF C-C motif chemokine 2 OS=Canis lupus familiaris OX=9615 GN=CCL2 PE=2 SV=1 ... IPR039809, Chemokine_b/g/d. IPR000827, Chemokine_CC_CS. IPR001811, Chemokine_IL8-like_dom. IPR036048, Interleukin_8-like_sf ... IPR039809, Chemokine_b/g/d. IPR000827, Chemokine_CC_CS. IPR001811, Chemokine_IL8-like_dom. IPR036048, Interleukin_8-like_sf ...
... stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 ... Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin- ... Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin- ... Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin- ...
However, anti-CCL2 antibody is ineffective at suppressing free CCL2 in humans (Sandu et al., 2013). Moreover, loss of CCL2 ... CCL2). We demonstrate here that, through activation of the CCL2 receptor CCR2, the recruited MAMs secrete another chemokine ... CC-chemokine ligand. CCR. CC-chemokine receptor. GEM. genetically engineered mouse. IM. inflammatory monocyte. MAM. metastasis- ... CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. ...
... by measuring chemokine MCP-1 (monocyte chemoattractant protein 1, CCL2) and prostaglandin E-2 (PGE2) in stimulated chondrocytes ... Chondrocyte Production of Pro-Inflammatory Chemokine MCP-1 (CCL-2) and Prostaglandin E-2 Is Inhibited by Avocado/Soybean ... by measuring chemokine MCP-1 (monocyte chemoattractant protein 1, CCL2) and prostaglandin E-2 (PGE2) in stimulated chondrocytes ... chemokines including MCP-1 (CCL2) and their receptors have been recognized as important players in OA pathogenesis [17] - [26 ...
3F). These data clearly demonstrate that murine γδ T cells use the CCR2/CCL2 chemokine pathway to migrate toward CCL2-rich B16 ... The CCR2/CCL2 pathway is required for γδ T cell recruitment to B16 tumors in vivo. WT, Ccl2−/−, or Ccr2−/− mice were injected s ... CCL2 and CCL12 accumulate in B16 tumor lesions lacking γδ T cells. Chemokine concentrations in protein extracts from day 14 ... Among the 25 chemokines profiled (Fig. 2, Supplemental Fig. 2), the CCR2 ligands CCL2 and CCL12 were significantly ...
Chemokines and their receptors have been detected in most tumors (1, 2). CCL2 remains one of the best studied chemokines. It ... Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases. Biomed Pap Med Fac Univ ... Fourth, CCL2 can suppress cytotoxic T lymphocytes. The multiple roles of CCL2 in the promotion of tumorigenesis make the CCL2/ ... C-C chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), is a member of the C-C beta chemokine ...
Chemokines and proteinases. Human CCL2/MCP-1, CCL8/MCP-3, CCL7/MCP-2, CCL13/MCP-4, CXCL1/Groα, CXCL2/Groβ, CXCL3/Groγ, CXCL5/ ... After the initial PMN influx, the next stage of inflammation is directed in part by CC chemokines consisting of CCL2/monocyte ... Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 ... Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 ...
CCL2; chemokine (C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; C-C motif chemokine 2; small- ... This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays ... Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is ... It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013] ...
... ... The chemokine CCL2 is overexpressed in breast cancer, correlating with poor patient prognosis. The purpose of this study was to ... To determine the role of CCL2 in breast cancer cells, CCL2 gene expression was silenced in mammary tumor tissues and cells ... Ca-TAT delivery of CCL2 siRNAs significantly reduced CCL2 expression in PyVmT mammary tumors, and decreased cell proliferation ...
Ccl2 Chemokine (C-C motif) ligand 2. Rn01456716_g1. NM_031530.1. Gfap Glial fibrillary acidic protein. Rn00566603_m1. NM_ ... Ccl2 Chemokine (C-C motif) ligand 2. Rn01456716_g1. NM_031530.1. Gfap Glial fibrillary acidic protein. Rn00566603_m1. NM_ ... the most well-characterized of these being chemokine (C-C motif) ligand 2 (Ccl2). 33 Ccl2 (also known as monocyte ... Ccl2 is a potent chemokine for monocytes in vitro 35 and is induced in a range of CNS diseases. 30 Its rapid site-specific ...
CCL2, requires reagent kit C III (171-304090 for vacuum separation or 171-304090M for magnetic separation) and a vial of ... Use the Bio-Plex Pro human chemokine MCP-1 / CCL2 singleplex set for the detection and quantification of MCP-1 / CCL2 from ... Bio-Plex Pro Human Chemokine Assays,Bio-Plex Pro Human Chemokine MCP-1 / CCL2 Set ... Benefits of the Human Chemokine MCP-1 / CCL2 Set. *Simplified assay processing with magnetic bead-based workflow to enable ...
We previously identified that the chemokine CCL2 was highly expressed in breast cancer associated fibroblasts. CCL2 is known to ... Examination of CCL2 level in blood and tumor sites revealed that CCL2 blocking significantly induced higher free CCL2 level, ... The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like ... We confirmed high CCL2 expression from CAFs isolated from primary human and mouse breast cancer samples. CAFs with high CCL2 ...
Contribution of the Chemokine (C-C Motif) Ligand 2 (CCL2) to Mechanical Hypersensitivity after Surgical Incision in Rats. ... Contribution of the Chemokine (C-C Motif) Ligand 2 (CCL2) to Mechanical Hypersensitivity after Surgical Incision in Rats ... Contribution of the Chemokine (C-C Motif) Ligand 2 (CCL2) to Mechanical Hypersensitivity after Surgical Incision in Rats ... CCL2, similar to other chemokines, was initially identified as an immunomodulatory factor that regulates activation and ...
The present study was undertaken to test the hypothesis that chemokine C-C motif ligand 2 (CCL2)-chemokine C-C motif receptor 2 ... Meanwhile, CCL2 expression was increased in the medullary dorsal horn (MDH) from 3 days to 21 days after IAMNT. The induced ... Targeting CCL2-CCR2 signaling may be a potentially important new treatment strategy for trigeminal neuralgia. ... The cellular localization of CCL2 and CCR2 were examined by immunofluorescence double staining. The effect of a selective CCR2 ...
CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells ... The CCL2 chemokine is also expressed by neurons, astrocytes and microglia. The expression of CCL2 in neurons is mainly found in ... CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1). The gene span is 1,927 bases and the CCL2 gene ... The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible ...
838P - Expression and clinical importance of e-cadherin, dysadherin and chemokine ligand 2 (CCL2) in renal cell carcinoma (RCC) ... Expression and clinical importance of e-cadherin, dysadherin and chemokine ligand 2 (CCL2) in renal cell carcinoma (RCC) ... Although moderate positive correlation between dysadherin and CCL2 (r= +0,25, p = 0.49), e-cadherin and CCL2 (r= +0.25, p = ... Dysadherin acts role either with E-cadherine dependent or CCL-2 mediated that E-cadherin independent. We studied expression and ...
Typical inflammatory chemokines include: CCL2, CCL3 and CCL5, CXCL1, CXCL2 and CXCL8. A typical example is CXCL-8, which acts ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ...
You need info about Sheep C-C motif chemokine 2 (CCL2) ELISA Kit or any other Gentaur produtct? Contact us on Live Chat Our ... Sheep (Ovis aries) CCL2 elisa. Shipping, handling and storage. The kit is shipped on ice packs. Upon receiving it store the kit ... Detects Sheep (Ovis aries) CCL2; Additional information. ...
Chemokines are key inflammatory mediators, several of which (MCP-1, RANTES, MIP-1α, fractalkine, SDF-1 among others) have been ... The important roles chemokines play in inflammation and pain make them an attractive therapeutic target. Peroxisome ... The important roles chemokines play in inflammation and pain make them an attractive therapeutic target. Peroxisome ... PPAR agonists have wide-ranging effects including inhibition of chemokine expression and pain behavior reduction in animal ...
Liu XS, Zhang ZG, Zhang RL, Gregg SR, Wang L, Yier T, Chopp M: Chemokine ligand 2 (CCL2) induces migration and differentiation ... Since elevated CCL2 initiates inflammatory reaction by increasing production of nitric oxide and other inflammatory chemokines ... We have earlier shown that protein levels of vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) were ... Gupta PK, Prabhakar S, Sharma S, Anand A: Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in ...
Our results further supported previous evidence of the important role of CCL2 in lung cancer development. ... Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung ... Chemokine (C-C motif) Ligand 2 (CCL2) was one of such chemokines important for both primary tumor development and metastasis of ... The CC chemokine ligand 2 (CCL2) polymorphism -2518A/G is associated with gout in the Chinese Han male population. Sun R, Zhang ...
Compare C-C motif chemokine ligand 2 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, ... CCL2, chemokine (C-C motif) ligand 2. *. Detection Range: 0.125 ng/ml-8 ng/ml ... Chemokine CC-1, Chemokine CC-3, Small Inducible Cytokine Subfamily A (Cys-Cys) Member 14) ... Chemokine CC-1, Chemokine CC-3, Small Inducible Cytokine Subfamily A (Cys-Cys) Member 14) ...
chemokine receptor activity. • receptor activity. • protein binding. • C-C chemokine receptor activity. • C-C chemokine binding ... Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[5] CCR6 ... "Entrez Gene: CCR6 chemokine (C-C motif) receptor 6".. *^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, ... "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
C-C Motif Chemokine Ligand 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... No data available for DME Specific Peptides for CCL2 Gene Domains & Families for CCL2 Gene Gene Families for CCL2 Gene. HGNC:. ... GeneCards Summary for CCL2 Gene CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA ... Evolution for CCL2 Gene. ENSEMBL:. Gene Tree for CCL2 (if available). TreeFam:. Gene Tree for CCL2 (if available). ...
CCL2 gene. C-C motif chemokine ligand 2. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays ... Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is ... It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013] ...
... to determine whether chemokines are responsible for the recruitme ... ObjectiveTo investigate in vivo expression of chemokines in ... The MCP-1 (CCL-2) showed the highest m RNA expression level of the CC chemokines, whereas Gro-α (CXCL-1) and IL-8 (CXCL-8) ... High Expression of Chemokines Gro-α (CXCL-1), IL-8 (CXCL-8), and MCP-1 (CCL-2) in Inflamed Human Corneas In Vivo. Arch ... Of all examined chemokines, only Gro-α (CXCL-1) and MCP-1 (CCL-2) showed high expression levels in limbal epithelium (Figure 3 ...
... ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain Antibody scFv Fragment is available from creative biolabs. ... chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain; ccl2; ccl3; ccl5; cxcl11; cxcl12; chemokine (C-C motif) ligand 2; ... Chemokine (ccl2, Ccl3, Ccl5, Cxcl11, Cxcl12) Single-domain. *Recombinant Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) ... ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain Antibody Fab Fragment ( MOB-198-F(E) ) Recombinant Human Anti-chemokine (ccl2, ...
Chemokine CCL2/genetics*. *Chemokine CCL2/metabolism. *Colon/metabolism. *Colon/pathology. *Crohn Disease/genetics* ... The chemokine MCP-1 is thought to be important for the recruitment of mononuclear cells and the maintenance of inflammation in ...
  • Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). (uniprot.org)
  • Here we examined in female and male adolescent rats a specific population of neurons concentrated in lateral hypothalamus, which coexpress the inflammatory chemokine C-C motif ligand 2 (CCL2) or its receptor CCR2 with the orexigenic neuropeptide, melanin-concentrating hormone (MCH), that promotes ethanol drinking behavior. (jneurosci.org)
  • Pulmonary metastasis of breast cancer cells is promoted by a distinct population of macrophages, metastasis-associated macrophages (MAMs), which originate from inflammatory monocytes (IMs) recruited by the CC-chemokine ligand 2 (CCL2). (rupress.org)
  • We demonstrate here that, through activation of the CCL2 receptor CCR2, the recruited MAMs secrete another chemokine ligand CCL3. (rupress.org)
  • Though C-C chemokine ligand 2 (CCL2) has been shown to play a pivotal role in prostate cancer tumorigenesis and invasion, the role of inherited variation in the CCL2 gene in prostate cancer progression and metastases remains unanswered. (aacrjournals.org)
  • C-C chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), is a member of the C-C beta chemokine family that is produced by macrophages, fibroblasts, and endothelial cells to stimulate chemotaxis of monocyte/macrophages and other inflammatory cells through its receptor, CCR2 ( 2, 3 ). (aacrjournals.org)
  • Several factors that activate glial cells in the spinal cord have been identified in neuropathic pain states, including adenosine triphosphate, tumor necrosis factor-α, chemokine (C-C motif) ligand 2 (CCL2), fractalkine (CX3CL1), and toll-like receptor agonists. (asahq.org)
  • The present study was undertaken to test the hypothesis that chemokine C-C motif ligand 2 (CCL2)-chemokine C-C motif receptor 2 (CCR2) signaling in the trigeminal nucleus is involved in the maintenance of trigeminal neuropathic pain. (biomedcentral.com)
  • Chemokine C-C motif ligand 2 (CCL2), also known as monocyte chemoattractant protein 1 (MCP-1), is a member of the chemokines family and can specifically recruit monocytes to sites of inflammation, infection, trauma, toxin exposure, and ischemia. (biomedcentral.com)
  • The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. (wikipedia.org)
  • We have earlier shown that protein levels of vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) were elevated in Indian amyotrophic lateral sclerosis (ALS) patients. (biomedcentral.com)
  • Chemokine (C-C motif) Ligand 2 (CCL2) was one of such chemokines important for both primary tumor development and metastasis of various cancers. (cdc.gov)
  • Your search returned 1131 C-C motif chemokine ligand 2 ELISA ELISA Kit across 31 suppliers. (biocompare.com)
  • CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. (genecards.org)
  • Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). (nih.gov)
  • Then, in this study, we analyze the role of NLRP3, PICs, chemokine ligand 2 (CCL2), C-X-C chemokine receptor type 3 (CXCR3), vascular cell adhesion molecule 1 (VCAM-1), and neurohormone level in the development of prehypertension. (springer.com)
  • Most chemokines bind to more than one receptor, while most receptors also display overlapping ligand specificity [ 5 ]. (mdpi.com)
  • This study aimed at determining the role of the chemokine (C-C motif) ligand (CCL)2 and CCL7 in ARDS. (bmj.com)
  • Neutrophil chemotaxis to ARDS BAL fluid was evaluated and the contribution of each was assessed and compared with chemokine (C-X-C motif) ligand 8 (CXCL8). (bmj.com)
  • To what extent do the chemokine (C-C motif) ligand (CCL)2 and CCL7 contribute to the migratory activity of neutrophils during acute respiratory distress syndrome (ARDS)? (bmj.com)
  • Both CCL2 and CCL7 contribute to neutrophil chemotaxis during ARDS by synergising with chemokine (C-X-C motif) ligand 8. (bmj.com)
  • Furthermore, our findings indicated that CC chemokine ligand 2 (CCL2) was involved in visfatin-mediated NCI-H446 cells transendothelial migtation. (mdpi.com)
  • We also aimed to assess the chemokine secretion by peripheral blood mononuclear cells (PBMC) upon polyclonal stimulus and to evaluate chemokine CC ligand 2/C-X-C chemokine 8 (CCL2/CXCL8) and Toll-like receptor-4 (TLR-4) expression in monocytes. (usp.br)
  • Following IFNγ, TNFα, IL-1β pro-inflammatory stress on Human Dermal Endothelial Cells (HDMEC) we observed the increased release of Chemokine ligand 2 (CCL2), IL-6 and IL-8 but not VEGF-A in the conditioned medium (CM). The subsequent addition of this endothelial pro-inflammatory CM in dermal fibroblasts revealed an upregulation of IL6 , IL8 and CCL2 but no NF-κB gene expression. (frontiersin.org)
  • These MCP-1 flox mice possess loxP sites flanking exons 1-2 of the chemokine (C-C motif) ligand 2 ( Ccl2 ) gene. (jax.org)
  • A targeting vector was designed to insert a single loxP site upstream of exon 1, and a loxP -flanked neomycin resistance (neo) cassette downstream of exon 2, of the chemokine (C-C motif) ligand 2 ( Ccl2 ) gene. (jax.org)
  • PMID 17763208 ] Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population. (snpedia.com)
  • Gene symbol Gene name change 303649 MCP1 chemokine (C-C motif) ligand 2 2. (thefreedictionary.com)
  • For example, T-bet induces modest activation of interleukin (IL)-2 receptor (2R)β (CD122) and CC chemokine ligand (CCL)3 depending on the cell type [ 5 ]. (ersjournals.com)
  • Results from oligonucleotide-based microarray, real-time PCR, and enzyme-linked immunosorbent assays indicated an upregulation of the fibrosis-associated chemokine (C-C motif) ligand 2 (CCL2) by the viral spike protein and the virus-like particles. (asm.org)
  • Chemokines and chemokine receptors are major mediators of leukocyte trafficking into the sites of the immune response. (aacrjournals.org)
  • It binds to chemokine receptors CCR2 and CCR4. (creative-biogene.com)
  • CCR2 and CCR4 are two cell surface receptors that bind CCL2. (wikipedia.org)
  • All of these proteins exert their biological effects by interacting with G protein-linked transmembrane receptors called chemokine receptors, that are selectively found on the surfaces of their target cells. (wikipedia.org)
  • Among other homeostatic chemokine receptors include: CCR9, CCR10, and CXCR5, which are important as part of the cell addresses for tissue-specific homing of leukocytes. (wikipedia.org)
  • Here, for the first time, we present a review of the literature linking chemokines in neuropathic pain to activation of peroxisome proliferator-activated receptors (PPARs). (frontiersin.org)
  • Among the genes repressed by activated PPARs are those of chemokines and their receptors. (frontiersin.org)
  • Nelson PJKrensky AM Chemokines, chemokine receptors, and allograft rejection. (jamanetwork.com)
  • Rossi DZlotnik A The biology of chemokines and their receptors. (jamanetwork.com)
  • To date, there are more than 50 chemokines and 18 chemokine receptors identified [ 6 ]. (mdpi.com)
  • Chemokines and chemokine receptors play a role in migration of circulating leukocytes to the region of inflammation . (bvsalud.org)
  • We investigated the role of human LZIP in expression of CC chemokine receptors (CCRs) and its involvement in monocyte migration. (bvsalud.org)
  • These results suggest that LZIP regulates expression of chemokine receptors that are involved in monocyte migration. (bvsalud.org)
  • MCP-1 binds to and exerts its biological activity through G-protein coupled chemokine receptors including CCR2/CD192 and CCR4/CD194. (fishersci.com)
  • Modulation of the expression of chemokines and chemokine receptors in whole blood was compared following infection of pigs with high and low virulence isolates of African swine fever virus. (beds.ac.uk)
  • Here we review the role of chemokines and their receptors in hepatitis C virus infection. (nih.gov)
  • 50 human chemokines and 18 chemokine receptors have been identified which can be divided into subfamilies based on the position of conserved cysteine residues within a conserved tetra-cysteine motif. (nih.gov)
  • In the subsequent 'triggering' stage chemokines (immobiised on endothelial proteoglycans activate chemokine receptors on leukocytes resulting in activation of integrin binding to endothelial ligands such as ICAM-1 and VCAM-1. (nih.gov)
  • Objectives While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. (bmj.com)
  • It has been found that chemokines and their receptors serve a pivotal role in HCC progression. (spandidos-publications.com)
  • Thus, chemokines and their receptors directly or indirectly shape the tumor cell microenvironment, and regulate the biological behavior of the tumor. (spandidos-publications.com)
  • Exosomes containing chemokines or expressing receptors for chemokines may improve chemotaxis to HCC and may thus be exploited for targeted drug delivery. (spandidos-publications.com)
  • Chemokines bind to a variety of different receptors, which belong to the G-protein-binding receptor family, and there are ~23 types of chemokine receptors that have been discovered ( 10 ). (spandidos-publications.com)
  • Chemokines and their receptors were initially thought to allow for an interaction between immune cells and the inflammatory sites ( 11 ). (spandidos-publications.com)
  • After binding to the receptors, chemokines primarily serve a role in migration of leukocytes, such as monocytes, eosinophils and dendritic cells (DCs) ( 11 ). (spandidos-publications.com)
  • Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (wikipathways.org)
  • Cells in the lamina propria, in turn, produce mediators (vii) that act on cytokine and chemokine receptors on intestinal epithelial cells. (jci.org)
  • Epithelial cells also express TLRs that respond to microbial products (e.g., bacterial flagellin signals through TLR5) and chemokine receptors (CCR6, CXCR4, CCR5, and CX3CR1) and can be induced to produce antimicrobial peptides (AMPs), such as -defensins and cathelicidin (viii). (jci.org)
  • In pulmonary sarcoidosis, T-bet upregulation is associated with changes in expression of IFN-γ, CXCR3 and chemokines/receptors involved in the pathogenesis of sarcoidosis, which suggests a role for T-bet in this Th1 disease, including modulation of some sarcoidosis-associated genes. (ersjournals.com)
  • Chemokines exhibit affinity for seven transmembrane-spanning G protein-coupled signaling receptors and extracellular matrix or cell-bound glycosaminoglycans (GAGs). (rupress.org)
  • CXCL8 promotes in vivo activation and recruitment of neutrophil granulocytes through the chemokine receptors 1 and 2 (CXCR1 and CXCR2) ( 7 , 8 ). (rupress.org)
  • Chemokine activity is controlled at different levels, including regulation of chemokine and chemokine receptor expression, the presence of "silent" or "decoy" chemokine receptors, binding to GAG, and posttranslational modification ( 9 - 13 ). (rupress.org)
  • Chemokines (chemotactic cytokines) and their receptors are widely expressed throughout the body. (ispub.com)
  • prostaglandin E(2), by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. (nih.gov)
  • The promoting or suppressive role of MSCs in cancer is controlled by various growth factors, cytokines and chemokines which affect the cell proliferation, angiogenesis and metastasis. (springer.com)
  • Mϕ play a crucial role in human host defense by secreting cytokines and chemokines, presenting antigen to T lymphocytes and clearing infectious agents. (pnas.org)
  • It is possible that the high fatality rate of SARS results from a severe immune response caused by cytokines and chemokines. (asm.org)
  • The CCL2/CCR2 mediated recruitment of monocytes is necessary for fighting infections to microorganisms [ 1 ]. (hindawi.com)
  • Extracellular nucleotide induction of CCL2 in cells expressing P2Y2 could be an important trigger for the initial recruitment of monocytes to an inflammatory site. (hindawi.com)
  • After the initial PMN influx, the next stage of inflammation is directed in part by CC chemokines consisting of CCL2/monocyte chemoattractant protein (MCP)-1, CCL7/MCP-3, CCL8/MCP-2, and CCL13/MCP-4, which target multiple leukocyte subsets (monocytes, T lymphocytes, basophils, and eosinophils). (bloodjournal.org)
  • After the Müller cell-driven expression of Ccl2, there was a substantial recruitment of monocytes to the local retina and choroidal vasculature. (arvojournals.org)
  • Furthermore, Ccl2 immunoreactivity was observed in many infiltrating monocytes after a 24-hour exposure. (arvojournals.org)
  • The data indicate that photoreceptor death promotes region-specific expression of Ccl2 by Müller cells, which facilitates targeting of monocytes to sites of injury. (arvojournals.org)
  • CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. (wikipedia.org)
  • CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. (wikipedia.org)
  • CCL2 exhibits a chemotactic activity for monocytes and basophils. (wikipedia.org)
  • Inflammatory chemokines function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or tissue damage. (wikipedia.org)
  • Also, up-regulation of CCL2 and CXCL8 mRNA expression was found in monocytes of patients upon SEA stimulation. (usp.br)
  • The findings showed a high responsiveness of monocytes through CCL2/CXCL8 expression, contributing to the creation of a proinflammatory environment in CIU. (usp.br)
  • We determined the impact of depleting T cells and Ly6C + monocytes as well as inhibiting the chemokine CCL2 on radiotherapy efficacy. (aacrjournals.org)
  • Ablative radiotherapy alone had minimal impact on PDAC growth but led to a significant increase in CCL2 production by tumor cells and recruitment of Ly6C + CCR2 + monocytes. (aacrjournals.org)
  • PDAC responds to radiotherapy by producing CCL2, which recruits Ly6C + CCR2 + monocytes to support tumor proliferation and neovascularization after radiotherapy. (aacrjournals.org)
  • By recruiting inflammatory monocytes/macrophages to the tumor microenvironment to promote tumor proliferation and vascularization, tumor-derived CCL2 inhibited the efficacy of ablative radiotherapy in a mouse model of PDAC. (aacrjournals.org)
  • Increased levels of CCL2, a chemoattractant for macrophages, may result in increased recruitment of monocytes from bone marrow thus increasing the pool of cells susceptible to infection. (beds.ac.uk)
  • The protective activity of the peptide was associated with in vivo augmentation of chemokine production and recruitment of neutrophils and monocytes to the site of infection. (jimmunol.org)
  • Conclusions Our findings demonstrate that monocytes recruited via CCL2/CCR2, rather than by CCL5/CCR5, propagate inflammation and tissue damage in OA. (bmj.com)
  • MCP-1 (monocyte chemoattracctant protein-1, also called C-C motif chemokine 2 or CCL2) is a secreted protein belonging to the intercrine beta (chemokine CC) family and specifically acts as a chemotactic factor to attract monocytes, CD4+ T cells, NK cells, and CCR2 expressing cells, but not neutrophils. (novusbio.com)
  • Taken together, we suggest that NTHI-induced SLF-derived MCP-1/CCL2 is a key molecule contributing to inner ear inflammation through CCR2-mediated recruitment of monocytes. (biomedcentral.com)
  • Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. (rndsystems.com)
  • The CCL2/CCR2 axis is required for recruitment of monocytes/macrophages and is implicated in various aspects of liver pathology, including HCC. (bmj.com)
  • Further, therapeutic blocking of the CCL2/CCR2 axis inhibits the recruitment of inflammatory monocytes, infiltration and M2-polarisation of TAMs, resulting in reversal of the immunosuppression status of the tumour microenvironment and activation of an antitumorous CD8 + T cell response. (bmj.com)
  • monocyte chemoattractant protein-1, (MCP-1)] is a CC chemokine that attracts monocytes, memory T lymphocytes, and basophils. (asm.org)
  • To address the need for alternatives, we evaluated the anti-inflammatory effects of a combination of avocado/soybean unsaponifiables (ASU), glucosamine (GLU) and chondroitin sulfate (CS) by measuring chemokine MCP-1 (monocyte chemoattractant protein 1, CCL2) and prostaglandin E-2 (PGE 2 ) in stimulated chondrocytes. (scirp.org)
  • The expression of ATF3, CCL2, glial fibrillary acidic protein (GFAP), and CCR2 were detected by immunofluorescence histochemical staining and western blot. (biomedcentral.com)
  • Targets of CCR2 signaling include mitogen-activated protein kinase (MAPK) [ 22 ], an important intracellular signaling in regulating neural plasticity and inflammatory responses [ 23 ], indicating CCL2-CCR2 may be involved in neuroinflammation and chronic pain. (biomedcentral.com)
  • The CCL2 protein precursor contains a signal peptide of 23 amino acids. (wikipedia.org)
  • CCL2 protein become a CCR2 antagonist when it is cleaved by metalloproteinase MMP-12. (wikipedia.org)
  • Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene . (wikipedia.org)
  • 1997). "CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells" . (wikipedia.org)
  • The CCL2 gene, encoding chemokine monocyte chemo-attractant protein 1 (MCP-1/CCL2), is one of several cytokine genes clustered on chromosome 17. (cdc.gov)
  • Methods CCL2 and CCL7 protein levels were measured in bronchoalveolar lavage (BAL) fluid obtained from lipopolysaccharide(LPS)-challenged human volunteers and two separate cohorts of patients with ARDS. (bmj.com)
  • LZIP also enhanced the chemotactic activities of monocyte chemoattractant protein-1 /CCL2 and Lkn-1. (bvsalud.org)
  • The 5D3-F7 monoclonal antibody specifically binds to human monocyte chemoattractant protein-1 (MCP-1), also known as CCL2 (C-C motif chemokine 2), Monocyte chemotactic and activating factor (MCAF), and Small-inducible cytokine A2 (SCYA2). (fishersci.com)
  • Levels of CCL2 mRNA were increased in pigs infected with high virulence Benin 97/1 isolate compared to low virulence OURT88/3 isolate and this correlated with an increase of greater than 30 fold in levels of CCL2 protein detected in serum from pigs infected with this isolate. (beds.ac.uk)
  • Expression profiling and real time PCR, as well as protein analysis, showed an increase in the expression of genes encoding for chemokines/cytokines regulating the adhesion process and mediators of vascular remodeling (ADAM17, MCP1, and Hsp60). (biomedsearch.com)
  • Mice homozygous for the huGFAP-MCP-1 transgene are viable and fertile, with expression of mouse monocyte chemoattractant protein-1 (MCP-1 or Ccl2 ) directed primarily to astrocytes of the CNS by the human glial fibrillary acidic protein ( GFAP ) promoter. (jax.org)
  • Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear. (uni-muenchen.de)
  • Conclusions: Ccl2/JE/MCP-1 and Ccl3/MIP-1α mediate firm adherence and (subsequent) transmigration of neutrophils via protein synthesis and secondary generation of leukotrienes and PAF, which in turn directly activate neutrophils. (uni-muenchen.de)
  • G SNP due to its position in the promoter of the monocyte chemoattractant protein-1 MCP-1 CCL2 gene, influences the production of its corresponding protein, a chemokine involved in inflammatory responses. (snpedia.com)
  • Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation. (snpedia.com)
  • Intramolecular disulphide bonds typically join the first to third, and the second to fourth cysteine residues, numbered as they appear in the protein sequence of the chemokine. (wikidoc.org)
  • The first two cysteines, in a chemokine, are situated close together near the N-terminal end of the mature protein, with the third cysteine residing in the centre of the molecule and the fourth close to the C-terminal end . (wikidoc.org)
  • The upregulation of CCL2 by SARS-CoV spike protein was mainly mediated by extracellular signal-regulated kinase 1 and 2 (ERK1/2) and AP-1 but not the IκBα-NF-κB signaling pathway. (asm.org)
  • These results indicate that SARS-CoV spike protein triggers ACE2 signaling and activates fibrosis-associated CCL2 expression through the Ras-ERK-AP-1 pathway. (asm.org)
  • Both pretreatment of A549 cells with SARS-CoV virus-like particles (VLPs) and preincubation of the cells with the viral spike protein upregulate the expression of fibrosis-associated CCL2. (asm.org)
  • We performed an association study between six single nucleotide polymorphisms (SNP) in the CCL2 gene and prostate cancer clinicopathologic variables in a large hospital-based Caucasian patient cohort ( N = 4,073). (aacrjournals.org)
  • Our study analyzes the role of 6 common polymorphisms in the CCL2 gene, as well as the haplotypes they composed, on the risk of developing aggressive prostate cancer. (aacrjournals.org)
  • To determine the role of CCL2 in breast cancer cells, CCL2 gene expression was silenced in mammary tumor tissues and cells using TAT cell-penetrating peptides non-covalently cross linked to siRNAs (Ca-TAT/siRNA). (ku.edu)
  • CCL2 gene silencing in PyVmT carcinoma cells or BT474 luminal B breast cancer cells decreased cell growth and viability associated with increased necrosis and autophagy. (ku.edu)
  • The gene span is 1,927 bases and the CCL2 gene resides on the Watson (plus) strand. (wikipedia.org)
  • The CCL2 gene has three exons and two introns. (wikipedia.org)
  • Platelet derived growth factor is a major inducer of CCL2 gene. (wikipedia.org)
  • Experimental evidence suggests a connection between the pain ameliorating effects of PPAR agonists and suppression of inflammatory gene expression, including chemokines. (frontiersin.org)
  • This knowledge, combined with advances in gene therapy and virology, allows researchers to employ chemokines as potential vaccine adjuvants. (mdpi.com)
  • Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Schönlein purpura susceptibility in Iranian Azeri-Turkish patients. (cdc.gov)
  • MCP1/CCL2 C-2518T gene polymorphism is associated with susceptibility to HSP. (cdc.gov)
  • Pretreatment of altenusin or GW4869 prior to lipopolysaccharide (LPS) stimulation for 4 or 24 hours, significantly downregulated gene expression of the pro-inflammatory mediators TNF- α , IL-1 β , IL-6, iNOS, and CCL2 in microglia and reduced the release of nitric oxide and TNF- α . (aspetjournals.org)
  • In addition, altenusin pretreatment also reduced the gene expression of multiple inflammatory markers associated with microglial activation after experimental TBI, including TNF- α , IL-1 β , IL-6, iNOS, CCL2, CD68, NOX2, and p22 phox . (aspetjournals.org)
  • These include (1) modulating the cholesterol content and thus reducing the stability of lipid raft formation and subsequent effects on the activation and regulation of immune cells, and (2) preventing the prenylation of signalling molecules and subsequent downregulation of gene expression, both resulting in reduced expression of cytokines, chemokines, and adhesion molecules with effects on cell apoptosis or proliferation. (bmj.com)
  • Intraganglionic CCL2 gene delivery recapitulates conditioning effects after spinal cord injury, suggesting that a chemokine signal mediating neuron-macrophage interaction may be a novel target for axon regeneration therapeutics. (jneurosci.org)
  • The huGFAP-MCP-1 transgene was designed with the 2.2 kb promoter region from the human GFAP gene upstream of a mouse 1.7 kb mouse Ccl2 genomic DNA sequence. (jax.org)
  • Many studies have demonstrated activation of P2Y2 induces a transient calcium response [ 11 , 12 ] but much less is known about the regulation of chemokine or cytokine production. (hindawi.com)
  • CCL2 is a small cytokine that belongs to the CC chemokine family. (wikipedia.org)
  • Cytokine proteins are classified as chemokines according to behavior and structural characteristics. (wikipedia.org)
  • Endothelial cells participate to synthesize and secrete chemokine and cytokine and are implicated in recruiting immune cells in response to dysfunctions due to different factors (e.g. (frontiersin.org)
  • Interleukin (IL)-6, a multifunctional cytokine with regulatory functions in wound healing, and several chemokines have been implicated in the pathogenesis of proliferative vitreoretinopathy (PVR) after rhegmatogenous retinal detachment (RRD). (arvojournals.org)
  • Chemokines are a class of small molecular proteins with similar structures, functions and chemotactic properties, and their molecular weights are ~10 kDa, and chemokines represent the largest member of the cytokine family ( 9 ). (spandidos-publications.com)
  • Both these effects result in reduced cytokine, chemokine, and adhesion molecule expression, with effects on cell apoptosis or proliferation. (bmj.com)
  • Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (snpedia.com)
  • Proteolytic processing regulates cytokine and chemokine activities. (rupress.org)
  • The basal secretion of CCL2 by PBMC or induced by Staphylococcus aureus enterotoxin A (SEA) was higher in CIU patients than in the control group, as well as for CXCL8 and CCL5 secretions upon phytohaemagglutinin stimulation. (usp.br)
  • Levels of mRNAs for CCL2, CCL3L1, CCL4, CXCL10, CCR1 and CCR5 were significantly increased in at least one time point following infection in two experiments and CCL5, CCR9 and CXCR4 mRNA were significantly increased in one of the experiments. (beds.ac.uk)
  • Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis. (bmj.com)
  • Methods Ccl2 -, Ccr2 -, Ccl5 - and Ccr5 -deficient and control mice were subjected to destabilisation of medial meniscus surgery to induce OA. (bmj.com)
  • Results Mice lacking CCL2 or CCR2, but not CCL5 or CCR5, were protected against OA with a concomitant reduction in local monocyte/macrophage numbers in their joints. (bmj.com)
  • In synovial fluids from patients with OA, levels of CCR2 ligands (CCL2, CCL7 and CCL8) but not CCR5 ligands (CCL3, CCL4 and CCL5) were elevated. (bmj.com)
  • This is the first study to report a significant association between MCP1/CCL2 C-2518T and a susceptibility to HSP in this population. (cdc.gov)
  • Western Blot: CCL2/MCP1 Antibody [NBP1-07035] - CCL2 expression level was evaluated in control group and aLAG-3 group. (novusbio.com)
  • Immunocytochemistry/ Immunofluorescence: CCL2/MCP1 Antibody [NBP1-07035] - MCP1 antibody was tested in HeLa cells with Dylight 488 (green). (novusbio.com)
  • Western Blot: CCL2/MCP1 Antibody [NBP1-07035] - TNF alpha treated PC12 lysates. (novusbio.com)
  • Nasdaq:CGEN) announced today the successful demonstration of functional activity for splice variants of c-Met receptor, MCP1 chemokine, and ANP hormone. (thefreedictionary.com)
  • Expression of IL6, CCL2/ MCP1 , CXCL1/GRO1, and CXCL2/GRO2 is decreased in human fibroblast cells after treatment with 5 [micro]M arsenite for 0-24 hr (Yih et al. (thefreedictionary.com)
  • The extracellular nucleotide signalling molecules UTP and ATP acting via the P2Y2 receptor are known to induce CCL2 secretion in macrophages. (hindawi.com)
  • Our previous work was the first to demonstrate a role for the P2Y2 receptor in regulation of CCL2 secretion from alveolar and peritoneal macrophages [ 10 ]. (hindawi.com)
  • These findings collectively indicate that the CCL2-triggered chemokine cascade in macrophages promotes metastatic seeding of breast cancer cells thereby amplifying the pathology already extant in the system. (rupress.org)
  • Administration of anti-CCL2 antibodies in a model of glomerulonephritis reduces infiltration of macrophages and T cells, reduces crescent formation, as well as scarring and renal impairment. (wikipedia.org)
  • The neuron-macrophage interactions that produced outgrowth-promoting conditioned medium required CCL2 in neurons and CCR2/CCR4 in macrophages. (jneurosci.org)
  • Intraganglionic injection of CCL2 mimicked conditioning injury by mobilizing M2-like macrophages. (jneurosci.org)
  • We report here that neuronal CCL2 induced by conditioning injury mediates neuron-macrophage interactions, resulting in accumulation of perineuronal macrophages with a proregenerative phenotype. (jneurosci.org)
  • Genetic or immunological inhibition of CCL2 abolished conditioning effects in vitro and in vivo , indicating that CCL2-mediated activation of proregenerative macrophages is essential in the conditioning injury-induced enhanced regenerative capacity. (jneurosci.org)
  • In vivo macrophage or T cell depletion and in vitro cell coculture were further conducted to investigate CCL2/CCR2-mediated crosstalk between tumour-associated macrophages (TAMs) and tumour cells. (bmj.com)
  • Furthermore, MMP-12 processed and inactivated monocyte chemotactic proteins CCL2, -7, -8, and -13 at position 4-5 generating CCR antagonists. (bloodjournal.org)
  • Luster AD Chemokines--chemotactic cytokines that mediate inflammation. (jamanetwork.com)
  • While a function of chemokines is to regulate lymphocyte trafficking, the view that chemokines act simply as "chemotactic cytokines" has evolved to include the many critical roles they play in regulating innate and adaptive immune responses. (mdpi.com)
  • BAL fluid from patients with ARDS was highly chemotactic for human neutrophils and neutralising either CCL2 or CCL7 attenuated the neutrophil chemotactic response. (bmj.com)
  • These chemotactic cytokines contain conserved cysteine residues in their amino (NH 2 )-terminal structure, a characteristic used for classification into CXC, CC, CX 3 C, and C chemokines ( 1 , 2 ). (rupress.org)
  • CXCL8 (IL-8), which contains the tripeptide Glu-Leu-Arg (ELR) in front of the first Cys residue, is an inflammatory CXC chemokine with potent neutrophil chemotactic and angiogenic properties ( 3 - 6 ). (rupress.org)
  • Chemokines are a family of small chemotactic cytokines, acting via G proteins in the cell surface. (ispub.com)
  • In addition, the function of immune cells and related chemicals in the mechanism of pain has been recognized, whereas few studies have addressed the potential role of chemokines in the trigeminal system in chronic pain. (biomedcentral.com)
  • The major role of chemokines is to act as a chemoattractant to guide the migration of cells. (wikipedia.org)
  • To decipher the role of chemokines in TB infection and disease, we measured the levels of chemokines in PTB, LTB and HC individuals. (nature.com)
  • My work so far has helped in clearly defining the role of chemokines in inflammation with particular relevance to transplantation. (ncl.ac.uk)
  • CCL2 may play a role in prostate cancer tumorigenesis and invasion and is highly expressed in the tumor microenvironment by human bone marrow endothelial cells. (aacrjournals.org)
  • CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. (wikipedia.org)
  • Their homeostatic function in homing is best exemplified by the chemokines CCL19 and CCL21 (expressed within lymph nodes and on lymphatic endothelial cells) and their receptor CCR7 (expressed on cells destined for homing in cells to these organs). (wikipedia.org)
  • MCP-1 (CCL2) is secreted by fibroblast, endothelial cells, smooth muscle cells, tumor cells, phytohemaglutinin stimulated mononuclear cells. (biolegend.com)
  • Chemokines are an important class of chemoattractant cytokines produced locally in tissues that provide the directional cues for the movement of blood-derived leukocytes in development, homeostasis, and inflammation. (bloodjournal.org)
  • The initial phase of inflammation involves a subset of CXC chemokines, which rapidly attract PMNs. (bloodjournal.org)
  • CCL2 may represent a molecular link in the negative cross-talk between adipose tissue and skeletal muscle assigning a completely novel important role to CCL2 besides inflammation. (wikipedia.org)
  • The important roles chemokines play in inflammation and pain make them an attractive therapeutic target. (frontiersin.org)
  • The chemokine MCP-1 is thought to be important for the recruitment of mononuclear cells and the maintenance of inflammation in inflammatory bowel disease. (nih.gov)
  • Chemokines are crucial for viral elimination, but inappropriate persistence of expression in chronic hepatitis C infection can drive tissue damage and inflammation. (nih.gov)
  • Martinez-Burgo B, Cobb S, Pohl E, Kashanin D, Paul T, Kirby JA, Sheerin N, Ali S. A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation . (ncl.ac.uk)
  • Within this area, specific interests include the role of cc chemokines in inflammation, their interaction with cell surface glycosaminoglycans and signal transduction mechanisms mediated by them. (ncl.ac.uk)
  • These huGFAP-CCL2 hi tg + transgenic mice may be useful for studying neurodegeneration, innate and adaptive immune system, inflammation, and demyelinating autoimmune disease (such as multiple sclerosis and EAE protocols). (jax.org)
  • Contrary to the in vitro data, deficiency of MCP-1/CCL2 or CCR2 did not inhibit OM-induced inner ear inflammation in vivo . (biomedcentral.com)
  • However, deficiency of MCP-1/CCL2 or CCR2 alone was limited to inhibit OM-induced inner ear inflammation due to compensation of alternative genes. (biomedcentral.com)
  • Upregulation of genes for interferon (IFN)-γ and CXC chemokine receptor (CXCR)3 expression, two crucial molecules in sarcoid inflammation and granuloma formation, is directly controlled by the T-helper (Th)1 transcription factor T-bet (T-box, expressed in T-cells). (ersjournals.com)
  • This study shows that PAD citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation. (rupress.org)
  • Chemokines are a family of small secreted proteins that activate and attract leukocytes during inflammation, but also play an important role in normal leukocyte trafficking, including lymphocyte homing. (rupress.org)
  • Incubation of HL-1 cardiomyocytes and human myocytes with oxidized-LDL induced the expression of BNP and CCL2 genes, while native LDL (N-LDL) had no effect. (wikipedia.org)
  • Polymorphism at rs3760396 of CCL2 genes is associated with the prognosis of non-small cell lung cancer (NSCLC). (cdc.gov)
  • qRT-PCR analysis was performed to demonstrate a compensatory up-regulation of alternative genes induced by the targeting of MCP-1/CCL2 or CCR2. (biomedcentral.com)
  • We aimed to test the therapeutic efficacy by blocking CCL2 in breast cancer mouse model through continuous delivery of CCL2 neutralizing antibody. (ku.edu)
  • Despite the steady delivery of the antibody, CCL2 blocking did not significantly affect tumor progression. (ku.edu)
  • CCL2 blocking by neutralizing antibody can lead to undesired increased CCL2 level, and alternative targeting approaches are needed to achieve therapeutic efficacy. (ku.edu)
  • Anti-CCL2 neutralizing antibody and CCR2 antagonist can completely abolish the increase in viability, proliferation, and invasiveness of ESCs induced by CCL2. (fertstertforum.com)
  • In addition to being known for mediating chemotaxis, chemokines are all approximately 8-10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikipedia.org)
  • For example, in addition to chemotaxis, chemokines modulate lymphocyte development, priming and effector function [ 2 ] and play a critical role in immune surveillance. (mdpi.com)
  • CCL2 also attenuated lymphocyte chemotaxis toward lymph node chemokines. (ashpublications.org)
  • The immunomodulatory activities of such peptides are extremely diverse and include stimulation of chemotaxis and chemokine production ( 7 , 8 ), promotion of leukocyte antimicrobial functions ( 9 ), regulation of neutrophil and epithelial cell apoptosis ( 10 , 11 ), regulation of dendritic cell differentiation and activation, stimulation of epithelial cell migration and wound healing, promotion of angiogenesis, and many others (reviewed in Refs. (jimmunol.org)
  • In addition, the potential application of chemokines in chemotaxis of exosomes as drug vehicles is discussed. (spandidos-publications.com)
  • P2Y2 and the UDP-responsive P2Y6 receptor can also signal other chemokine productions including CXCL8 (IL-8) and CCL20 (MIP-3 α ) [ 9 , 13 , 14 ]. (hindawi.com)
  • Moreover, CCL2 and CCL7 synergised with CXCL8 to promote neutrophil migration. (bmj.com)
  • We observed significantly higher serum levels of the CXCL8, CXCL9, CXCL10 and CCL2 in CIU patients compared to the healthy group, regardless of the BHR or ASST response. (usp.br)
  • In an attempt to better understand such discrepancies, we studied alternatively modified chemokines and discovered a novel natural posttranslational modification of CXCL8, i.e., the conversion of one specific Arg into Cit. (rupress.org)
  • We propose that the macrophage, specifically through MMP-12, assists in orchestrating the regulation of acute inflammatory responses by precise proteolysis of ELR + CXC and CC chemokines. (bloodjournal.org)
  • Second, CCL2 has a modulatory effect on the tumor microenvironment by promoting macrophage mobilization and infiltration into the tumor bed. (aacrjournals.org)
  • CCL2 is known to recruit monocyte/macrophage and promotes cancer progression. (ku.edu)
  • In contrast, selective blockade of CCL2 using neutralizing antibodies blocked monocyte/macrophage recruitment to tumors and, in combination with radiotherapy, produced antitumor activity with enhanced survival. (aacrjournals.org)
  • Further, blockade of CCL2/CCR2 signalling markedly attenuated macrophage accumulation, synovitis and cartilage damage in mouse OA. (bmj.com)
  • The present study identifies a novel chemokine signal mediated by CCL2 that links regenerating neurons with proregenerative macrophage activation. (jneurosci.org)
  • Neutralization of CCL2 abolished the neurite outgrowth activity of conditioned medium obtained from neuron-macrophage cocultures treated with cAMP. (jneurosci.org)
  • Our data suggest that CCL2-mediated neuron-macrophage interaction plays a critical role for amplification and maintenance of enhanced regenerative capacity by preconditioning peripheral nerve injury. (jneurosci.org)
  • Manipulation of chemokine signaling mediating neuron-macrophage interactions may represent a novel therapeutic approach to promote axon regeneration after CNS injury. (jneurosci.org)
  • CCL2 and its receptor CCR2 are involved in inflammatory reactions, including monocyte/macrophage migration, Th2 cell polarization, and the production of TGF-β and procollagen in fibroblast cells ( 9 , 10 ). (asm.org)
  • We have used the preclinical transplantable B16 melanoma model to profile chemokines in tumor lesions and assess their impact on γδ TIL recruitment in vivo. (jimmunol.org)
  • Moreover, CCL2 directed γδ T cell migration in vitro toward tumor extracts, which was abrogated by anti-CCL2 neutralizing Abs. (jimmunol.org)
  • Strikingly, the lack of γδ TILs in TCRδ-deficient but also in CCR2-deficient mice enhanced tumor growth in vivo, thus revealing an unanticipated protective role for CCR2/CCL2 through the recruitment of γδ T cells. (jimmunol.org)
  • This work identifies a novel protective role for CCL2/CCR2 in the tumor microenvironment, while opening new perspectives for modulation of human Vδ1 T cells in cancer immunotherapy. (jimmunol.org)
  • First, CCL2 has a direct promotional effect on tumor cell growth and survival. (aacrjournals.org)
  • Third, CCL2 can promote osteoclast maturation in the bone tumor microenvironment. (aacrjournals.org)
  • Reduction of CCL2 expression by CRISPR mutation or shRNA knockdown in human or mouse CAFs significantly reduced tumor growth in the co-graft model. (ku.edu)
  • Examination of CCL2 level in blood and tumor sites revealed that CCL2 blocking significantly induced higher free CCL2 level, which may contribute to lack of efficacy. (ku.edu)
  • CCL2 augments monocyte anti-tumor activity and it is essential for formation of granulomas. (wikipedia.org)
  • Chemokines are well known inflammatory factors critical for tumor development in diverse tissues, including lung cancer. (cdc.gov)
  • Recent discoveries in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing recruitment of antigen presenting cells (APCs) and effector cells to appropriate anatomical sites. (mdpi.com)
  • Chemokines are involved in the inflammatory response, tumor immune response, proliferation, invasion and metastasis via modulation of various signaling pathways. (spandidos-publications.com)
  • CCL2 has been shown to have direct effects on tumor cells in an autocrine and paracrine fashion in multiple cancers, including breast, lung, cervix, ovary, sarcoma, and prostate. (biolegend.com)
  • Tumor PD-L1 altered tumor chemokines (e.g. (aacrjournals.org)
  • Tumor PD-L1 alteration of immune infiltrates by altering chemokines is a novel mechanism for PD-L1 TIL control. (aacrjournals.org)
  • Finally, αPD-L1 directly altered tumor cell chemokine production in vitro, suggesting additional, novel αPD-L1 treatment mechanisms requiring more study. (aacrjournals.org)
  • Conversely, PAF and LTB4, but not Ccl2/JE/MCP-1 and Ccl3/MIP-1α, directly activated neutrophils as indicated by shedding of CD62L and marked upregulation of CD11b. (uni-muenchen.de)
  • Moreover, Ccl2/JE/ MCP-1- and Ccl3/MIP-1α-elicited leakage of fluorescein isothiocyanate dextran as well as collagen IV remodeling within the venular basement membrane were completely absent in neutrophil-depleted mice. (uni-muenchen.de)
  • After deletion of the N-terminal residue, CCL2 loses its attractivity for basophils and becomes a chemoattractant of eosinophils. (wikipedia.org)
  • Chemokines are a group of related chemoattractant peptides that are essential regulators of the immune system, both during homeostatic and inflammatory conditions. (mdpi.com)
  • CCL2 is an important inflammatory chemokine involved in monocyte recruitment to inflamed tissues. (hindawi.com)
  • To investigate the time course and localization of Ccl2 expression and recruitment of inflammatory cells associated with light-induced photoreceptor degeneration. (arvojournals.org)
  • Chemokines are felt to play a major role latent TB infection (LTB) as they appear to be critical in the formation and maintenance of quiescent granulomas 4 and in the recruitment of cells from the periphery for positioning within the granuloma 5 . (nature.com)
  • Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. (creative-biogene.com)
  • Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. (wikipedia.org)
  • Chemokines are a superfamily of small proteins that promote leukocyte migration and orchestrate the immune response to viruses, including hepatitis C virus. (nih.gov)
  • Chemokines are a family of small cytokines , or proteins secreted by cells . (wikidoc.org)
  • Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikidoc.org)
  • Proteins are classified into the chemokine family based on their structural characteristics, not just their ability to attract cells. (wikidoc.org)
  • Typical chemokine proteins are produced as pro-peptides , beginning with a signal peptide of approximately 20 amino acids that gets cleaved from the active (mature) portion of the molecule during the process of its secretion from the cell. (wikidoc.org)
  • Chemokines are small cytokines, or signaling proteins, secreted by cells. (wikipathways.org)
  • VEGF-A and CCL2 mRNA upregulation in PBMCs may have a clinico-pathological/etiological/epidemiological association with ALS pathogenesis. (biomedcentral.com)
  • chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. (bioportfolio.com)
  • Chemokines also have an important role in pathogenesis. (scielo.br)
  • In the human osteoclasts, CCL2 and RANTES (regulated on activation normal T cell expressed and secreted). (wikipedia.org)
  • It is proposed that CCL2 and RANTES act as autocrine loop in human osteoclast differentiation. (wikipedia.org)
  • Chemokines are key inflammatory mediators, several of which (MCP-1, RANTES, MIP-1α, fractalkine, SDF-1 among others) have been linked to chronic, neuropathic pain in both human conditions and animal models. (frontiersin.org)
  • Genetic variation at CCL2 is associated with markers of disease aggressiveness. (aacrjournals.org)
  • Genetic deletion of CCL2 in PDAC cells also improved radiotherapy efficacy. (aacrjournals.org)
  • CCL2 impairs insulin signaling in skeletal muscle cells via ERK1/2 activation at doses similar to its physiological plasma concentrations (200 pg/mL), but does not involve activation of the NF-κB pathway. (wikipedia.org)
  • The ESC-derived CCL2 enhances the expression of proliferating cell nuclear antigen, survivin, and matrix metalloproteinase-2, decreases tissue inhibitor of metalloproteinase 1/2 expression, and promotes the growth and invasiveness of ESCs in an autocrine manner through the Akt and MAPK/Erk1/2 signal pathway. (fertstertforum.com)
  • The CCL2 can increase the expression of proliferating cell nuclear antigen, survivin, and matrix metalloproteinase 2, and decrease the expression of tissue inhibitor of metalloproteinase 1 and 2, and promote the viability, proliferation and invasiveness of ESCs by activating Akt and MAPK/Erk1/2 signal pathway, but not p38 and JNK signal pathway. (fertstertforum.com)
  • CCL2 might play an important role in regulating the functions of ESCs through Akt and MAPK/Erk1/2 signal pathway, and overexpression of CCL2 in ESCs and peritoneal fluid (PF) would lead to onset and development of endometriosis. (fertstertforum.com)
  • This pathway was inferred from Mus musculus pathway "Chemokine signaling pathway", WP2292 revision 89521, with a 91.0% conversion rate. (wikipathways.org)
  • In addition, Ras and Raf upstream of the ERK1/2 signaling pathway were involved in the upregulation of CCL2. (asm.org)
  • Mutation of the CCL2 receptor CCR2 receptor in CA1D cancer cell significantly reduced cancer cells growth in vitro and in vivo in response to CCL2 stimulation. (ku.edu)
  • Here, we report that CCL2 (at picomolar [pM] levels) renders both murine and human T cells defective in their ability to develop CCR7-triggered activation of LFA-1- and LFA-1-mediated adhesion strengthening to endothelial ICAM-1 both in vitro and in vivo. (ashpublications.org)
  • These results highlight the importance of the chemokine induction activity of host defense peptides and demonstrate that the optimization of the ex vivo chemokine-induction properties of peptides is a promising method for the rational development of immunomodulatory IDR peptides with enhanced anti-infective activity. (jimmunol.org)
  • My subsequent work has convincingly shown that this chemokine-GAG interaction is essential for in vivo activity of these cytokines ( American Journal of Transplantation, 2010, 10:47-58, PNAS, 2012 ). (ncl.ac.uk)
  • In this study, an immunomodulatory peptide IDR-1002 was selected from a library of bactenecin derivatives based on its substantially more potent ability to induce chemokines in human PBMCs. (jimmunol.org)
  • B ) Summary of P991_AMBCA IC 50 data (moles/litre, mean, s.e.m. of 3 biological replicates analyzed as above) for chemokines that induce THP-1 cell migration. (nature.com)
  • Consequently, low-dose CCL2 inhibited lymphocyte homing to peripheral lymph nodes but did not affect lymphocyte trafficking through the spleen. (ashpublications.org)
  • Important major human chemokines that act on cells of the lymphocyte and monocyte lineages are shown. (nih.gov)
  • We previously identified that the chemokine CCL2 was highly expressed in breast cancer associated fibroblasts. (ku.edu)
  • In summary, our studies have showed that CCL2 derived from cancer associated fibroblasts plays an important role in basal-like breast cancer progression. (ku.edu)
  • Following tissue/cellular damage or regulated nucleotide release from cells or nerve terminals, the activation of P2Y2 by extracellular nucleotides could switch on a rapid production of CCL2. (hindawi.com)
  • Importantly, we demonstrate that human Vδ1 T cells, but not their Vδ2 counterparts, express CCR2 and migrate to CCL2, whose expression is strongly deregulated in multiple human tumors of diverse origin, such as lung, prostate, liver, or breast cancer. (jimmunol.org)
  • The purpose of this study was to determine the role of CCL2 expression in luminal B breast cancer cells. (ku.edu)
  • CCL2 expression is overexpressed in luminal B breast cancer cells and is important for regulating cell growth and survival by inhibiting necrosis and autophagy. (ku.edu)
  • Immunohistochemistry and in situ hybridization showed that Ccl2 is expressed by Müller cells from 12 hours of exposure, most intensely in the superior retina, in the region of the incipient light-induced lesion. (arvojournals.org)
  • We previously found that recombinant CCL2 can directly signal to breast cancer cells and promote cell survival and invasion in vitro. (ku.edu)
  • The CCL2/CCR2 signaling activated PKC and SRC pathways in cancer cells, and contributed to growth promotion. (ku.edu)
  • Direct signaling to cancer cells via CCR2 is an important mechanism in CCL2 function. (ku.edu)
  • Basophils and mast cells that are treated with CCL2 release their granules to the intercellular space. (wikipedia.org)
  • The expression of CCL2 in neurons is mainly found in the cerebral cortex, globus pallidus, hippocampus, paraventricular and supraoptic hypothalamic nuclei, lateral hypothalamus, substantia nigra, facial nuclei, motor and spinal trigeminal nuclei, gigantocellular reticular nucleus and in Purkinje cells in the cerebellum. (wikipedia.org)
  • CCL2 expression in glial cells is increased in epilepsy, brain ischemia Alzheimer's disease experimental autoimmune encephalomyelitis (EAE), and traumatic brain injury. (wikipedia.org)
  • Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. (wikipedia.org)
  • Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. (wikipedia.org)
  • Some chemokines control cells of the immune system during processes of immune surveillance, such as directing lymphocytes to the lymph nodes so they can screen for invasion of pathogens by interacting with antigen-presenting cells residing in these tissues. (wikipedia.org)
  • These are known as homeostatic chemokines and are produced and secreted without any need to stimulate their source cells. (wikipedia.org)
  • Other chemokines are inflammatory and are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. (wikipedia.org)
  • Certain inflammatory chemokines activate cells to initiate an immune response or promote wound healing. (wikipedia.org)
  • VEGF-A and CCL2 mRNA levels were measured in peripheral blood mononuclear cells (PBMCs) of 50 sporadic Indian ALS patients using Real Time Polymerase Chain Reaction (PCR) and compared with normal controls (n = 50). (biomedcentral.com)
  • We now measured the mRNA expression of VEGF-A and CCL2 in peripheral blood mononuclear cells (PBMCs) of these patients. (biomedcentral.com)
  • 1997). "Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells" . (wikipedia.org)
  • On the other hand, the chemokine system also plays a crucial role in the induction of antitumor immune responses and optimal effector function regulation of immune cells [ 1 , 4 , 5 ]. (mdpi.com)
  • In particular, visfatin-induced CCL2 was attenuated by specific inhibitor of PI3K/Akt signaling in NCI-H446 cells. (mdpi.com)
  • To clarify the role and mechanism of CCL2 in regulating the biological functions of endometrial stromal cells (ESCs). (fertstertforum.com)
  • Chemokines released by infected or damaged cells form a concentration gradient. (wikipedia.org)
  • Attracted cells move through the gradient towards the higher concentration of chemokine. (wikipedia.org)
  • Y-axis shows cell count of THP-1 cells migrating through to the bottom chamber in response to EC 80 dose of CCL2. (nature.com)
  • A major rol of chemokines is to act as chemoattractants in guiding migration of cells. (wikipathways.org)
  • This migratory activity was markedly inhibited by the viral CC chemokine inhibitor and the deficiency of MCP-1/CCL2, indicating that MCP-1/CCL2 is a main attractant of THP-1 cells among the SLF-derived molecules. (biomedcentral.com)
  • CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. (rndsystems.com)
  • Growth of three murine HCC cells was evaluated in an orthotopic model, a postsurgical recurrence model and a subcutaneous model in mice after blocking CCL2/CCR2 axis by a novel CCR2 antagonist or knocking out of host CCR2. (bmj.com)
  • In the early 1990s, my laboratory discovered that intestinal epithelial cells could alter their phenotype and produce proinflammatory chemokines and cytokines when stimulated by pathogenic enteric luminal microbes or proinflammatory agonists produced by cells in the underlying mucosa. (jci.org)
  • It is now well accepted that intestinal epithelial cells can be induced to express and secrete specific arrays of cytokines, chemokines, and antimicrobial defense molecules. (jci.org)
  • A ) Intestinal epithelial cells can be induced to express chemokines and cytokines in response to encounter with enteric microbial pathogens. (jci.org)
  • In response, the intestinal epithelium can change its phenotype to produce chemokines and cytokines (v) that act on underlying cells of the innate and adaptive immune system in the lamina propria (vi). (jci.org)
  • A key role in granuloma formation is played by interferon (IFN)-γ [ 3 ] and T-helper (Th) type-1 cells accumulating in the sarcoid lungs, which express chemokine receptor CXC chemokine receptor (CXCR)3 [ 4 ]. (ersjournals.com)
  • CCL2 expression was examined by ELISA and flow cytometry. (ku.edu)
  • Chemokine receptor expression on neutrophils from blood or BAL fluid of patients with ARDS was analysed by flow cytometry. (bmj.com)
  • Chemokines are functionally divided into two groups: Homeostatic: are constitutively produced in certain tissues and are responsible for basal leukocyte migration. (wikipedia.org)
  • The main function of chemokines is to manage the migration of leukocytes (homing) in the respective anatomical locations in inflammatory and homeostatic processes. (wikipedia.org)
  • Inflammatory: inflammatory chemokines are produced in high concentrations during infection or injury and determine the migration of inflammatory leukocytes into the damaged area. (wikipedia.org)
  • Conclusion This study highlights important inflammatory chemokines involved in regulating neutrophil migration, which may have potential value as therapeutic targets for the treatment of ARDS. (bmj.com)
  • Once in tissue, the cell follows chemokine gradients to sites of infection using chemokine-mediated changes in the actin cytoskeleton to propel migration. (nih.gov)
  • A ) Neutralization of CCL2 induced THP-1 cell migration by P991_AMBCA. (nature.com)
  • NIL indicates baseline migration without any chemokine. (nature.com)
  • Migration assays were conducted using the conditioned medium of NTHI-exposed SLFs with and without inhibition of MCP-1/CCL2 and CCR2. (biomedcentral.com)
  • Key inflammatory mediators that are known to participate in chronic pain, including chemokines, have emerged as new therapeutic targets. (frontiersin.org)
  • While much remains to be understood about how PPAR agonists achieve this effect, it seems probable that inhibiting the expression of pain-causing inflammatory mediators like chemokines represents at least one mechanism for pain reduction. (frontiersin.org)
  • Here, we report the mRNA levels of VEGF-A and CCL2 in Indian ALS patients since they display extended survival after disease onset. (biomedcentral.com)
  • VEGF-A and CCL2 mRNA levels were found to be significantly elevated in PBMCs in ALS patients as compared to controls. (biomedcentral.com)
  • CCL2 mRNA levels were found to be unaltered when definite, probable and possible ALS were compared. (biomedcentral.com)
  • The CCL2 chemokine is also expressed by neurons, astrocytes and microglia. (wikipedia.org)
  • Fibroblasts condition medium or recombinant CCL2 directly promoted CA1D cancer cell growth in vitro. (ku.edu)
  • We have found that the secretion of CCL2 by the eutopic ESCs from endometriosis is higher than that of healthy ESCs without endometriosis. (fertstertforum.com)
  • Our main objectives were to evaluate the relation between proinflammatory chemokine serum levels from CIU patients and their response to autologous skin test (ASST) and basophil histamine release (BHR). (usp.br)
  • CCL2 and its receptor CCR2 have recently been shown to play key roles in promoting tumorigenesis and metastasis via distinct mechanisms ( 4-7 ). (aacrjournals.org)
  • Single-nucleotide polymorphism (SNP) analysis of CCL2 has suggested that this chemokine may play a role in host susceptibility to the development of cancer and/or cancer metastasis ( 8-10 ). (aacrjournals.org)
  • It has been found that chemokine networks may serve pivotal roles in inducing organ-specific metastasis ( 8 ). (spandidos-publications.com)
  • Blockade of CCL2/CCR2 signalling with knockout of CCR2 or with a CCR2 antagonist inhibits malignant growth and metastasis, reduces postsurgical recurrence, and enhances survival. (bmj.com)
  • You need info about Sheep C-C motif chemokine 2 (CCL2) ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • Your search returned 672 CCL2 ELISA ELISA Kit across 42 suppliers. (biocompare.com)
  • We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. (jneurosci.org)
  • We show that these neuronal and behavioral changes are similarly produced by maternal administration of CCL2 (4 or 8 μg/kg/d, E10-E15) and blocked by maternal administration of a CCR2 antagonist INCB3344 (1 mg/kg/d, E10-E15), and these effects of ethanol and CCL2 are sexually dimorphic, consistently stronger in females. (jneurosci.org)
  • These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women. (jneurosci.org)
  • This suggests that neuronal chemokine signaling linked to neuropeptides mediates effects of maternal ethanol exposure on adolescent offspring and contributes to higher levels of adolescent risk factors for alcohol use disorders in women. (jneurosci.org)
  • The induced CCL2 was colocalized with astroglial marker GFAP, but not with neuronal marker NeuN or microglial marker OX-42. (biomedcentral.com)
  • The data suggest that CCL2-CCR2 signaling may be involved in the maintenance of orofacial neuropathic pain via astroglial-neuronal interaction. (biomedcentral.com)
  • CCL2 is involved in the neuroinflammatory processes that takes place in the various diseases of the central nervous system (CNS), which are characterized by neuronal degeneration. (wikipedia.org)
  • Conclusions In patients with liver cancer, CCL2 is highly expressed and is a prognostic factor. (bmj.com)
  • Results also showed that the upregulation of CCL2 in the co-culture system was reversed by blockade of visfatin. (mdpi.com)
  • Blockade of CCL2/CCR2 signalling suppresses murine liver tumour growth via activating T cell antitumour immune response. (bmj.com)
  • The results demonstrate the translational potential of CCL2/CCR2 blockade for treatment of HCCs. (bmj.com)
  • Rather, mMMP-12 cleavage at Ser4-Val5 activated the chemokine, promoting enhanced PMN early infiltration in wild-type mice compared with Mmp12 −/− mice 8 hours after LPS challenge in air pouches. (bloodjournal.org)
  • Mice containing the floxed Ccl2 tm1Tyos allele were crossed with EIIa-Cre mice to remove the floxed neo cassette. (jax.org)
  • The conditioning effects were abolished in CCL2-deficient mice at 3 and 7 d after sciatic nerve injury, but CCL2 was dispensable for the initial growth response and upregulation of GAP-43 at the 1 d time point. (jneurosci.org)
  • These huGFAP-MCP-1 hi tg + transgenic mice display chronic overexpression of mouse Ccl2 directed primarily to astrocytes of the CNS by the human GFAP promoter. (jax.org)
  • Mice derived from the high-expressing founder line 95 (also called huGFAP-MCP-1 hi tg + , huGFAP-CCL2 hi tg + , or JE-95 mice) overexpress CCL2 in an astroglial activation-dependent manner. (jax.org)
  • Levels of CCL2 expression in the CNS of huGFAP-CCL2 hi tg + mice were comparable with those observed in CNS tissues from mice with experimental autoimmune encephalomyelitis (EAE). (jax.org)
  • With chronic overexpression of CCL2, aged huGFAP-CCL2 hi tg + mice develop DESMO (delayed encephalopathy/neurodegeneration spontaneously occurring with MCP-1 (CCL2) overexpression). (jax.org)
  • In addition, huGFAP-CCL2 hi tg + mice are a model for pertussis toxin-induced reversible encephalopathy dependent on MCP-1 (CCL2) overexpression (PREMO). (jax.org)
  • Mice from this founder line were found to have the highest expression of the transgene, and were termed huGFAP-MCP-1 hi tg+ mice (also called huGFAP-CCL2 hi tg+ mice or JE-95 mice). (jax.org)
  • This chemokine signalling axis has also been implicated in a number of inflammatory disorders where monocyte infiltration is a key factor such as atherosclerosis, multiple sclerosis, and rheumatoid arthritis [ 2 ]. (hindawi.com)
  • Peak monocyte infiltration followed maximum Ccl2 expression by up to 3 days. (arvojournals.org)
  • Results CCL2 and CCL7 were significantly elevated in BAL fluid recovered from LPS-challenged volunteers and patients with ARDS. (bmj.com)
  • Furthermore, neutrophils isolated from the blood or BAL fluid differentially regulated the cell surface expression of chemokine (C-X-C motif) receptor 1 and C-C chemokine receptor type 2 during ARDS. (bmj.com)
  • To investigate how neurochemical and neuroimmune systems interact to mediate these disturbances, we examined a specific population of hypothalamic neurons coexpressing the inflammatory chemokine CCL2 and its receptor CCR2 with the neuropeptide, melanin-concentrating hormone. (jneurosci.org)
  • We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. (jneurosci.org)
  • In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1). (wikipedia.org)
  • This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. (creative-biogene.com)
  • To date, >50 chemokines have been found, which can be divided into four families: CXC, CX3C, CC and XC, according to the different positions of the conserved N‑terminal cysteine residues. (spandidos-publications.com)
  • 50 chemokines have been identified, which can be divided into four families: CXC, CX3C, CC and XC, based on the different positions of the conserved N-terminal cysteine residues ( 9 ). (spandidos-publications.com)
  • All chemokines share a typical Greek key structure that is stabilised by disulphide bonds between conserved cysteine residues. (wikidoc.org)
  • rs3760396 G/C polymorphism of CCL2 was genotyped using PCR in 394 patients with lung cancer and 545 cancer-free controls from the same Northeast region of China. (cdc.gov)
  • CCL2, C-2518T polymorphism genotypes were determined by polymerase chain reaction and by PVUII restriction enzyme analysis and subsequent agarose gel electrophoresis. (cdc.gov)
  • A comparison of clinical symptoms and laboratory data with CCL2 C-2518T polymorphism showed that patients with the TT genotype presented a higher clinical score and more severe clinical features. (cdc.gov)
  • We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease. (bioportfolio.com)
  • The multiple roles of CCL2 in the promotion of tumorigenesis make the CCL2/CCR2 axis an attractive therapeutic target for cancer treatment. (aacrjournals.org)
  • Thus, the CCL2/CCR2 signaling may serve as potential therapeutic targets in basal-like breast cancer. (ku.edu)
  • This review will focus on recent murine and human studies that use chemokines as therapeutic anti-cancer vaccine adjuvants. (mdpi.com)
  • Selective targeting of the CCL2/CCR2 system represents a promising therapeutic approach for OA. (bmj.com)
  • MCP-1/CCl2 has been described as a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. (biolegend.com)
  • We investigated the feasibility of CCL2/CCR2 as a therapeutic target against HCC. (bmj.com)
  • The results showed that greatest fold increases in mRNAs for CXCL10 and CCL2 were observed following infection of pigs. (beds.ac.uk)
  • This coincided spatially with the expression of Ccl2 in the superior retina. (arvojournals.org)
  • We evaluated the expression of CCL2 and fibroblast marker Fsp1 in breast cancer tissue microarray containing 427 samples by immunohistochemistry. (ku.edu)
  • Expression of CCL2 and Fsp1 were co-upregulated in invasive ductal carcinoma compared to normal breast. (ku.edu)
  • Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates-e.g., psoriasis, rheumatoid arthritis, atherosclerosis. (thefreedictionary.com)
  • The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. (bioportfolio.com)
  • Upregulation of Ccl2 expression was evident in the retina by 12 hours of exposure and correlated with increased photoreceptor death. (arvojournals.org)
  • In addition, upregulation of CCL2 was detected in the sera of SARS patients and the supernatant of a SARS-CoV-infected culture system ( 5 , 16 ). (asm.org)
  • However, mechanisms by which SARS-CoV is involved in the upregulation of CCL2 are not known. (asm.org)