Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Clinical Chemistry Tests: Laboratory tests demonstrating the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Combinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Blood Chemical Analysis: An examination of chemicals in the blood.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Nobel PrizeMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Chemistry Techniques, Synthetic: Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.Green Chemistry Technology: Pollution prevention through the design of effective chemical products that have low or no toxicity and use of chemical processes that reduce or eliminate the use and generation of hazardous substances.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Chemistry, Physical: The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.Evolution, Chemical: Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Azides: Organic or inorganic compounds that contain the -N3 group.Biochemistry: The study of the composition, chemical structures, and chemical reactions of living things.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Cosmic Dust: Finely divided solid matter with particle sizes smaller than a micrometeorite, thus with diameters much smaller than a millimeter, moving in interplanetary space. (NASA Thesaurus, 1994)Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Extraterrestrial Environment: The environment outside the earth or its atmosphere. The environment may refer to a closed cabin (such as a space shuttle or space station) or to space itself, the moon, or other planets.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biogenesis: The origin of life. It includes studies of the potential basis for life in organic compounds but excludes studies of the development of altered forms of life through mutation and natural selection, which is BIOLOGICAL EVOLUTION.Atmosphere: The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)Organic Chemistry Processes: The reactions, changes in structure and composition, the properties of the reactions of carbon compounds, and the associated energy changes.Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Astronomy: The science concerned with celestial bodies and the observation and interpretation of the radiation received in the vicinity of the earth from the component parts of the universe (McGraw Hill Dictionary of Scientific and Technical Terms, 5th ed)Quantum Theory: The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Molecular Conformation: The characteristic three-dimensional shape of a molecule.Photoelectron Spectroscopy: The study of the energy of electrons ejected from matter by the photoelectric effect, i.e., as a direct result of absorption of energy from electromagnetic radiation. As the energies of the electrons are characteristic of a specific element, the measurement of the energy of these electrons is a technique used to determine the chemical composition of surfaces.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.History, 19th Century: Time period from 1801 through 1900 of the common era.Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Radiochemistry: The study of the chemical and physical phenomena of radioactive substances.Drug Discovery: The process of finding chemicals for potential therapeutic use.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Enzymes: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.Gases: The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Coordination Complexes: Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Exobiology: The interdisciplinary science that studies evolutionary biology, including the origin and evolution of the major elements required for life, their processing in the interstellar medium and in protostellar systems. This field also includes the study of chemical evolution and the subsequent interactions between evolving biota and planetary evolution as well as the field of biology that deals with the study of extraterrestrial life.Photochemical Processes: Chemical reactions effected by light.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.History, 18th Century: Time period from 1701 through 1800 of the common era.Kinetics: The rate dynamics in chemical or physical systems.Autoanalysis: Method of analyzing chemicals using automation.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Sulfhydryl Compounds: Compounds containing the -SH radical.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Solar System: The group of celestial bodies, including the EARTH, orbiting around and gravitationally bound by the sun. It includes eight planets, one minor planet, and 34 natural satellites, more than 1,000 observed comets, and thousands of lesser bodies known as MINOR PLANETS (asteroids) and METEOROIDS. (From Academic American Encyclopedia, 1983)Hydrocarbons, Cyclic: Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.Small Molecule Libraries: Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.Hematologic Tests: Tests used in the analysis of the hemic system.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Fullerenes: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Silanes: Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)History, 20th Century: Time period from 1901 through 2000 of the common era.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Ecotoxicology: The study of ENVIRONMENTAL POLLUTION and the toxic effects of ENVIRONMENTAL POLLUTANTS on the ECOSYSTEM. The term was coined by Truhaut in 1969.Dendrimers: Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Chemical Processes: The reactions and interactions of atoms and molecules, the changes in their structure and composition, and associated energy changes.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Microscopy, Scanning Tunneling: A type of scanning probe microscopy in which a very sharp conducting needle is swept just a few angstroms above the surface of a sample. The tiny tunneling current that flows between the sample and the needle tip is measured, and from this are produced three-dimensional topographs. Due to the poor electron conductivity of most biological samples, thin metal coatings are deposited on the sample.Electrons: Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Metal Nanoparticles: Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.PhotochemistryFluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Electrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.Particle Size: Relating to the size of solids.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Elements: Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.Molecular Probes: A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.Biomimetics: An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Spectrum Analysis: The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cyclooctanes: A group of compounds with an 8-carbon ring. They may be saturated or unsaturated.Wettability: The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid.Meteoroids: Any solid objects moving in interplanetary space that are smaller than a planet or asteroid but larger than a molecule. Meteorites are any meteoroid that has fallen to a planetary surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Agrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Volcanic Eruptions: The ash, dust, gases, and lava released by volcanic explosion. The gases are volatile matter composed principally of about 90% water vapor, and carbon dioxide, sulfur dioxide, hydrogen, carbon monoxide, and nitrogen. The ash or dust is pyroclastic ejecta and lava is molten extrusive material consisting mainly of magnesium silicate. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ions: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Physicochemical Phenomena: The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.Nanomedicine: The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).Laboratories: Facilities equipped to carry out investigative procedures.Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Environmental Pollution: Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.History, 21st Century: Time period from 2001 through 2100 of the common era.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Solid-Phase Synthesis Techniques: Techniques used to synthesize chemicals using molecular substrates that are bound to a solid surface. Typically a series of reactions are conducted on the bound substrate that results in either the covalent attachment of specific moieties or the modification of existing function groups. These techniques offer an advantage to those involving solution reactions in that the substrate compound does not have to be isolated and purified between the reaction steps.Hydrocarbons, FluorinatedBenzene DerivativesChromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Glass: Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Laboratories, Hospital: Hospital facilities equipped to carry out investigative procedures.Lightning: An abrupt high-current electric discharge that occurs in the ATMOSPHERE and that has a path length ranging from hundreds of feet to tens of miles. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Silicon Dioxide: Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Evolution, Planetary: Creation and development of bodies within solar systems, includes study of early planetary geology.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Aldehydes: Organic compounds containing a carbonyl group in the form -CHO.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Blood Urea Nitrogen: The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Chemistry, Inorganic: A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).Acid Rain: Acidic water usually pH 2.5 to 4.5, which poisons the ecosystem and adversely affects plants, fishes, and mammals. It is caused by industrial pollutants, mainly sulfur oxides and nitrogen oxides, emitted into the atmosphere and returning to earth in the form of acidic rain water.Nucleic Acids: High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Spectrum Analysis, Raman: Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Nucleic Acid Probes: Nucleic acid which complements a specific mRNA or DNA molecule, or fragment thereof; used for hybridization studies in order to identify microorganisms and for genetic studies.IminesNitrogen Oxides: Inorganic oxides that contain nitrogen.Groundwater: Liquid water present beneath the surface of the earth.Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Saturn: The sixth planet in order from the sun. It is one of the five outer planets of the solar system. Its twelve natural satellites include Phoebe and Titan.Microscopy, Atomic Force: A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Bromine: A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Anions: Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.Microfluidic Analytical Techniques: Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Interdisciplinary Studies: Programs of study which span the traditional boundaries of academic scholarship.Ferric Compounds: Inorganic or organic compounds containing trivalent iron.Earth (Planet): Planet that is the third in order from the sun. It is one of the four inner or terrestrial planets of the SOLAR SYSTEM.Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)Eagles: Large members of the FALCONIFORMES order of birds, family Accipitridae, most especially the genera Aquila, Haliaeetus, Harpia, and Circaetus. They are characterized by their powerful talons, which carry long, curved, pointed claws and by their opposable hindtoe.Microfluidics: The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.KetonesCations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Bilirubin: A bile pigment that is a degradation product of HEME.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Biochemical Phenomena: The chemical processes, enzymatic activities, and pathways of living things and related temporal, dimensional, qualitative, and quantitative concepts.Seawater: The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.Macrocyclic Compounds: Cyclic compounds with a ring size of approximately 1-4 dozen atoms.Natural Science Disciplines: The sciences dealing with processes observable in nature.Isotope Labeling: Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Lanthanoid Series Elements: Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).Halogenation: Covalent attachment of HALOGENS to other compounds.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Polystyrenes: Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.HydrocarbonsAlpha Particles: Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Transition Elements: Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.Biocatalysis: The facilitation of biochemical reactions with the aid of naturally occurring catalysts such as ENZYMES.Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Graphite: An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.

In-vivo therapeutic efficacy in experimental murine mycoses of a new formulation of deoxycholate-amphotericin B obtained by mild heating. (1/2621)

Heat-induced 'superaggregation' of deoxycholate-amphotericin B (AmB-DOC, Fungizone) was shown previously to reduce the in-vitro toxicity of this antifungal agent. We compared AmB-DOC with the formulation obtained by heating the commercial form (Fungizone, Bristol Myers Squibb, Paris, France) for 20 min at 70 degrees C, in the treatment of murine infections. An improvement of antifungal activity was obtained with heated AmB-DOC formulations due to a lower toxicity which allowed the administration of higher drug doses than those achievable with the commercial preparation. Single intravenous injections of heated AmB-DOC solutions were demonstrated to be two-fold less toxic than unheated ones to healthy mice. For mice infected with Candida albicans, the maximum tolerated dose was higher with heated than with unheated AmB-DOC solutions. In the model of murine candidiasis, following a single dose of heated AmB-DOC 0.5 mg/kg, 85% of mice survived for 3 weeks, whereas at this dose the immediate toxicity of the standard formulation in infected mice restricted the therapeutic efficacy to 25% survival. Both formulations were equally effective in increasing the survival time for murine cryptococcal pneumonia and meningoencephalitis. Injection of heated AmB-DOC solutions at a dose two-fold higher than the maximal tolerated dose observed with the unheated preparation (1.2 mg/kg) increased the survival time by a factor of 1.4 in cryptococcal meningoencephalitis. These results indicate that mild heat treatment of AmB-DOC solutions could provide a simple and economical method to improve the therapeutic index of this antifungal agent by reducing its toxicity on mammalian cells.  (+info)

A study of local anaesthetics. Part 148. Influence of auxiliary substances on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII. (2/2621)

The influence of auxiliary substances of the polyol group (glycerol, propylene glycol, sorbitol) and of their concentration (5, 10, 15 and 20% by weight) upon surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII, viz., N-[2-(2-propoxyphenylcarbamoyloxy)-ethyl] piperidinium chloride was studied. The substances were applied as hydrogel humectants. It was found that their influence on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII depended on the type as well as concentration of the auxiliary substance. From the viewpoints of use in formulations of the drug form, sorbitol used at 5 and 10% concentrations represented the optimum.  (+info)

Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. (3/2621)

The kinetics of T-helper immune responses generated in 16 mature outbred rhesus monkeys (Macaca mulatta) within a 10-month period by three different human immunodeficiency virus type 1 (HIV-1) vaccine strategies were compared. Immune responses to monomeric recombinant gp120SF2 (rgp120) when the protein was expressed in vivo by DNA immunization or when it was delivered as a subunit protein vaccine formulated either with the MF59 adjuvant or by incorporation into immune-stimulating complexes (ISCOMs) were compared. Virus-neutralizing antibodies (NA) against HIV-1SF2 reached similar titers in the two rgp120SF2 protein-immunized groups, but the responses showed different kinetics, while NA were delayed and their levels were low in the DNA-immunized animals. Antigen-specific gamma interferon (IFN-gamma) T-helper (type 1-like) responses were detected in the DNA-immunized group, but only after the fourth immunization, and the rgp120/MF59 group generated both IFN-gamma and interleukin-4 (IL-4) (type 2-like) responses that appeared after the third immunization. In contrast, rgp120/ISCOM-immunized animals rapidly developed marked IL-2, IFN-gamma (type 1-like), and IL-4 responses that peaked after the second immunization. To determine which type of immune responses correlated with protection from infection, all animals were challenged intravenously with 50 50% infective doses of a rhesus cell-propagated, in vivo-titrated stock of a chimeric simian immunodeficiency virus-HIVSF13 construct. Protection was observed in the two groups receiving the rgp120 subunit vaccines. Half of the animals in the ISCOM group were completely protected from infection. In other subunit vaccinees there was evidence by multiple assays that virus detected at 2 weeks postchallenge was effectively cleared. Early induction of potent type 1- as well as type 2-like T-helper responses induced the most-effective immunity.  (+info)

Low-oestrogen oral contraceptives.(4/2621)

 (+info)

A new strategy for treating nets. Part 1: formulation and dosage. (5/2621)

The conventional dosages of pyrethroid insecticides on mosquito nets assume that nets will be retreated at 6-12 month intervals. However, dosage should be related to washing of nets; if nets are only washed once or twice a year, their dosage requirements will be different to those which are washed fortnightly. A 'low-dose, frequent-wash' retreatment system might be technically more appropriate and more affordable where nets are washed frequently, as they are in Dar es Salaam. Moreover, for use as a domestic insecticide, water-based formulations of pyrethroid are preferable to the more commonly used emulsifiable concentrates (ECs). This paper reports laboratory evaluations of three formulations (ECs, Flowable, CS) of three pyrethroids (deltamethrin, lambdacyhalothrin, permethrin). Insecticidal activity was tested using serial bioassays at a range of dosages using Anopheles gambiae. The water-based formulations were no less effective than the ECs, even at the lowest dosages. Nets treated with 3 mg/m2 and then repeatedly washed and retreated after each wash with either 3 mg/m2 or 1 mg/m2 were subjected to gas chromatography analysis. This showed that the amounts of pyrethroid in the nets accumulated rapidly over the first few wash-retreatment cycles and then remained fairly stable over subsequent cycles. These nets gave consistently high bioassay mortalities throughout the experiment, while the mortality declined rapidly after several washes with the nets that were treated at 3 mg/m2 but not retreated. Experimental huts were used to compare the effectiveness of these 2 net retreatment regimes and nets which were not retreated. All nets caused high mortality rates amongst Anopheles females, but had negligible effects on culicines; either in killing them or in preventing feeding. Therefore use of a high 'loading' dose for initial treatment with lower 'maintenance' doses for retreatment may be preferable to ensure that net users promptly perceive the benefits of the insecticide against culicines.  (+info)

A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. (6/2621)

BACKGROUND: Modern pancreatin preparations consist of enteric-coated microspheres to protect the enzymes from gastric acid. There are, however, no clinical trials comparing different sizes of pancreatin microspheres with regard to fat excretion and fat intake. AIM: To prove both equivalent efficacy and safety of conventional pancreatin microspheres and smaller pancreatin minimicrospheres in patients with exocrine insufficiency due to chronic pancreatitis. METHODS: In this prospective, randomized, double-blind, multicentre, crossover trial, patients with a stool fat excretion of > 7.5 g/day during a placebo period were randomly assigned either to the minimicrosphere/microsphere treatment sequence or vice versa. The primary end-point was the coefficient of fat absorption, which was calculated from fat excretion and fat intake during the course of a standardized diet. Stool weight, clinical symptoms and the safety of the preparations were also evaluated. RESULTS: Thirty-seven patients entered the study, of whom 23 fulfilled the criteria for the crossover period. In the per protocol analysis (n=18), the 90% confidence intervals for the coefficient of fat absorption of both crossover periods lay entirely within the equivalence range (P=0.02). The intention-to-treat analysis revealed similar results, but the equivalence range was slightly missed (P=0.07). Similar results were obtained for the secondary parameters and the reported adverse events. CONCLUSIONS: Pancreatin minimicrospheres have been shown to be equally effective as microspheres in improving the coefficient of fat absorption in patients with exocrine insufficiency due to chronic pancreatitis.  (+info)

Pharmacokinetic and pharmacodynamic characterization of OROS and immediate-release amitriptyline. (7/2621)

AIMS: To characterize the pharmacokinetics of amitriptyline and its metabolite nortriptyline following OROS and IR treatments, and to correlate them with anticholinergic side-effects. METHODS: The pharmacokinetics and safety of amitriptyline following administration of an osmotic controlled release tablet (OROS and an immediate release (IR) tablet were evaluated in 14 healthy subjects. In this randomized, open label, three-way crossover feasibility study, the subjects received a single 75 mg OROS tablet, three 25 mg IR tablets administered every 8 h, or 3x25 mg IR tablets administered at nighttime. In each treatment arm serial blood samples were collected for a period of 84 h after dosing. The plasma samples were analysed by gas chromatography for amitriptyline and its metabolite nortriptyline. Anticholinergic effects such as saliva output, visual acuity, and subject-rated drowsiness and dry mouth were measured on a continuous scale during each treatment period. RESULTS: Following dosing with OROS (amitriptyline hydrochloride), the mean maximal plasma amitriptyline concentration Cmax (15.3 ng ml-1 ) was lower and the mean tmax (25.7 h) was longer than that associated with the equivalent IR dose administered at nighttime (26.8 ng ml-1 and 6.3 h, respectively). The bioavailability of amitriptyline following OROS dosing was 95% relative to IR every 8 h dosing, and 89% relative to IR nighttime dosing. The metabolite-to-drug ratios after the three treatment periods were similar, suggesting no change in metabolism between treatments. The relationships between plasma amitriptyline concentration and anticholinergic effects (e.g. reduced saliva weight, dry mouth, and drowsiness) were similar with all three treatments. Of the anticholinergic effects, only decreased saliva weight and dry mouth correlated well with plasma amitriptyline concentrations; drowsiness did not. There was no apparent correlation between anticholinergic effects and the plasma nortriptyline concentration. CONCLUSIONS: The bioavailability of OROS (amitriptyline hydrochloride) was similar to that of the IR treatments and the pharmacokinetics of amitriptyline after OROS dosing may decrease the incidence of anticholinergic effects compared with that seen with nighttime dosing of the IR formulation. Therefore, this controlled-release formulation of amitriptyline may be appropriate for single daily administration.  (+info)

The pharmacology of gene therapy. (8/2621)

The objective for human gene therapy is to express exogenous DNA at a site in vivo for long enough, and at sufficient levels to produce a therapeutic response. The obstacles to this objective are numerous and include the formulation or packaging of the DNA, in vivo delivery, penetration of biological barriers, DNA elimination within the cell and from the tissue compartments of the whole body, control of product expression and overt toxicity. The current challenge is to resolve each of these obstacles to produce a practical and efficient gene therapy. In doing so, it is vital to understand the disposition of DNA vectors in vivo, and to know how conventional medicines may be used to modulate this disposition and to enhance the therapeutic effect of these vectors. Many of the general concepts of human gene therapy have been reviewed extensively in the literature. This review discusses some of the pharmacological aspects of gene delivery and the fate of vectors in vivo, and then highlights how drugs are being used to modulate gene therapy.  (+info)

Octadentate Zirconium(IV)-Loaded Macrocycles with Varied Stoichiometry Assembled From Hydroxamic Acid Monomers following scientific download Solving Polynomial Equation. high Chemistry, 56(6), 3719-3728. medieval download Solving Polynomial Equation Systems III: Volume 3, Algebraic: towing Combinatorial Pools of Drug Leads From Enzyme-Mediated Fragmentation of Natural Products. ChemBioChem, 18(4), 368-373. posting Up the publications of the Desferrioxamine B Jigsaw Defines the Biosynthetic Sequence Catalyzed by DesD. ACS Chemical Biology, 11(5), 1452-1462. extensive download Solving Polynomial Equation Systems III: Volume 3, Algebraic Solving of way, excellence and training by Shewanella capsules and air of sales with properties), molybdenum(VI) or chromium(V). Journal of Inorganic Biochemistry, 162, 207-215. The BET download claim is the most different helpful precursor kinds with drafting capabilities and study inefficiencies. Oncotarget, 7(48), 79217-79232. frequently and discover( Retro) ...
... is a field of mathematics which combines two different branches of study, specifically algebra and linear algebra. Algebra and linear algebra can be defined as (1):. Algebra: A field of mathematics which analyzes polynomial equations using letters and symbols to represent unknown values. Linear Algebra: The investigation of a system of linear equations using several variables. Thus, algebraic geometry uses several variables for systems of polynomial equations. Algebraic geometry does not necessarily aim to solve these equations, but rather formulate statements about the geometric structure for the set of solutions belonging to these polynomial equations (algebraic varieties). When studying algebraic geometry, polynomial equations can be of various degrees (denoted as d). Polynomial equations of several variables are investigated to discover what their geometric structure might be. Algebraic geometry is a rather abstract field of mathematics. It is a field which involves a lot ...
Drug formulations market research report covering industry trends, market share, market growth analysis and projection by MIcroMarketMonitor.com. Drug formulations market report includes,|Key question answered| What are market estimates and forecasts; which of Drug formulations markets are doing well and which are not? and |Audience for this report| Drug formulations companies.
Drug formulations market research report covering industry trends, market share, market growth analysis and projection by MIcroMarketMonitor.com. Drug formulations market report includes,|Key question answered| What are market estimates and forecasts; which of Drug formulations markets are doing well and which are not? and |Audience for this report| Drug formulations companies.
Medicinal Chemistry 2014 Conferences, Medicinal Chemistry 2014 Conferences Photos, Medicinal Chemistry 2014 Conferences Images, Medicinal Chemistry 2014 Conference Gallery, Medicinal Chemistry 2014 Event Images
TY - JOUR. T1 - Influence of formulation parameters on dissolution rate enhancement of glyburide using liquisolid technique. AU - Singh, S.K.. AU - Srinivasan, K.K.. AU - Gowthamarajan, K.. AU - Prakash, D.. AU - Gaikwad, N.B.. AU - Singare, D.S.. N1 - cited By 16. PY - 2012. Y1 - 2012. U2 - 10.3109/03639045.2011.634810. DO - 10.3109/03639045.2011.634810. M3 - Article. VL - 38. SP - 961. EP - 970. JO - Drug Development and Industrial Pharmacy. JF - Drug Development and Industrial Pharmacy. SN - 0363-9045. IS - 8. ER - ...
#pharmaceutical chemistry #Pharmaceutical Chemistry Journal About this journal More than 40 years in publication through 2007, the monthly Pharmaceutical Chemistry Journal is devoted to scientific and technical research on the creation of new drugs and the improvement of manufac More than 40 years in publication through 2007, the monthly Pharmaceutical Chemistry Journal is devoted to…
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.. ...
Early phase pharmaceutical development. Almacs formulation scientists can develop a range of oral dose formulations for early stage clinical trials.
García González, N., Kellaway, I. W., Blanco Fuente, H., Anguiano Igea, S., Delgado Charro, B., Otero Espinar, F. J. and Blanco Méndez, J., 1994. Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels. International Journal of Pharmaceutics ...
STA Pharmaceutical Co., Ltd. (STA) - a WuXi AppTec group company and the leading open-access capability and technology platform for small molecule pharmaceutical development and manufacturing
Lipid-based formulations (LBFs) is a formulation strategy for enabling oral delivery of poorly water-soluble drugs. However, current use of this strategy is limited to a few percent of the marketed products. Reasons for that are linked to the complexity of LBFs, chemical instability of pre-dissolved drug and a limited understanding of the influence of LBF intestinal digestion on drug absorption. The aim of this study was to explore intestinal drug solubilization from a long-chain LBF, and evaluate whether coadministration of LBF is as efficient as a lipidbased drug formulation containing the pre-dissolved model drug carvedilol. Thus, solubility studies of this weak base were performed in simulated intestinal fluid (SIF) and aspirated dog intestinal fluid (DIF). DIF was collected from duodenal stomas after dosing of water and two levels (1 g and 2 g) of LBF. Similarly, the in vitro SIF solubility studies were conducted prior to, and after addition of, undigested or digested LBF. The DIF fluid was ...
In vitro dissolution testing is a critical component of drug product development programs and is often used as a surrogate for in vivo performance. Consequently, mechanistic modelling of in vitro dissolution studies and informed data interpretation early in the formulation development process is crucial. The Simcyp In Vitro (Data) Analysis (SIVA) toolkit is a standalone […]. ...
While every effort has been made to reproduce these formulations correctly, the Publisher of this website cannot accept any liability for the information presented. All formulations are provided in good faith, but no warranty is given as to accuracy of information or results, or suitability for a particular use, nor is freedom from patent infringement to be inferred. Formulations are offered solely for consideration by the participating manufacturers. Continued use of this web site infers acceptance of this disclaimer. ...
|p||em|Reaxys Medicinal Chemistry enables scientists to explore new drug candidates through a comprehensive database with new search features, refined user-interface and integration with Reaxys|/em||/p|
Pharmacy and Clinical Research. Heath Care. Medical. M.S. (Pharm.):Medicinal Chemistry in Punjab. M.S. (Pharm.):Medicinal Chemistry. The department is engaged in the following areas of research Identification and validation of novel target sites for various therapeutic areas: Design and synthesis of new chemical entities as anticancer, antileishmanial
Medicinal Chemistry, a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design...
Medicinal Chemistry, a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design...
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design, and has impact factor 3.853.
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design, and has impact factor 3.853.
This international, multicentric, prospective, observational study is being conducted to assess the safety profile, efficacy and adherence to Rebif® New Formulation in real life settings in subjects with relapsing remitting multiple sclerosis (RRMS), as well as the impact of this improved formulation (with regards to adverse events [AEs]) to subjects adherence. Three hundred and fifty subjects from approximately 80 sites across seven countries will be enrolled in the study. Subjects will be treated with IFN beta-1a (Rebif® New Formulation) in real life settings according to the clinical and paraclinical course and laboratory findings as routinely evaluated by the physician. Data related to AEs; subjects adherence to treatment, reasons for treatment discontinuation; number and reasons of missed injections; and the clinical and paraclinical data on efficacy regarding relapses will be captured. Data will be reported prospectively throughout the duration of the study (12 months) at two visits ...
... are not only vital to consumer safety, but are also important for product quality for Pharmaceuticals, Cosmetics, Chemicals, Food and other Markets. Learn more now »
PreSens optical measurement systems can be applied in manifold applications. Read articles about how our customers applied PreSens devices in their experiments and what experiences they made!
While every effort has been made to reproduce these formulations correctly, the Publisher of this website cannot accept any liability for the information presented. All formulations are provided in good faith, but no warranty is given as to accuracy of information or results, or suitability for a particular use, nor is freedom from patent infringement to be inferred. Formulations are offered solely for consideration by the participating manufacturers. Continued use of this web site infers acceptance of this disclaimer. ...
Find Leading Pharmaceutical Formulations Manufacturers, Suppliers, Exporters and Traders at one place. Contact Exporters India for more information about Pharmaceutical Formulations manufacturers
In addition to size, particles of low density (typically , 0.1 g/cm3) are desirable for high-efficiency delivery to the lungs. It is a strategy borrowed from nature in the dispersal of spores and pollen.. Most dry powder inhalant products on the market are lactose blends of coated crystalline small molecules.. "If you design the right powder-one that fluidizes and disperses at low energy-you can make a simpler device," he said. "If a device is simpler for patients to use, they are more adherent to their medication.". For these reasons, Miller believes that engineered particles are the future of the industry.. "One way I look at characterization of engineered particles is its another solid dosage form," he said. "Those of you who work on tablets, our lives are quite similar.". When it comes to topical formulations, product characteristics include pH, particle size, polymorphism, rheological studies, globule size, and dissolved/undissolved drug.. The quality attribute of highest interest is the ...
Assessment: 3-hour examination (85%), best 3 out of 4 assessed worksheets (15%).. Prerequisites: MA106 Linear Algebra, MA249 Algebra II: Groups and Rings. Leads To: Content: Galois theory is the study of solutions of polynomial equations. You know how to solve the quadratic equation $ ax^2+bx+c=0 $ by completing the square, or by that formula involving plus or minus the square root of the discriminant $ b^2-4ac $ . The cubic and quartic equations were solved ``by radicals in Renaissance Italy. In contrast, Ruffini, Abel and Galois discovered around 1800 that there is no such solution of the general quintic. Although the problem originates in explicit manipulations of polynomials, the modern treatment is in terms of field extensions and groups of ``symmetries of fields. For example, a general quintic polynomial over $Q$ has five roots $ \alpha_1.\dots.\alpha_5 $ , and the corresponding symmetry group is the permutation group $ S_5 $ on these.. Aims: The course will discuss the problem of ...
Can anyone give me a hard factoring polynomial equation? (If possible, the question can have the combination of factoring techniques.)Okay, Ill gi...
Course Pre-requisites. This course is based on the contents of the Austrian Matura, which comprises:. Fundamental Operations with Numbers (Real Numbers, Exponents, Powers, Fractions, etc.), Fundamental Operations with Algebraic Expressions (Terms, Degrees, Grouping, Computations, etc.), Properties of Numbers, Special Products, Factoring (Factorization Procedures, Greatest Common Factor, Least Common Multiple), Fractions (Operations with Fractions, Rational Algebraic Fractions, Complex Fractions), Exponents (Integral Exponents, Roots, Rational Exponents, General Laws of Exponents, etc.), Radicals (Radical Expressions, Laws for Radicals, Operations with Radicals, Rationalizing Binomial Denominators, etc.), Operations with Complex Numbers (Graphical Representation of, Algebraic Operations with Complex Numbers, etc.), Equations (Transformation, Equivalent Equations, Polynomial Equations, etc.), Ratio/Proportion/Variation, Functions and Graphs (Variables, Relations, Functions, Function Notations, ...
The study of zero sets of polynomial equations. Examples are the parabola y − x2 = 0, thought of as sitting in the (x, y)-plane, and the locus of all points (t, t2, t3, t4), which is defined by Eqs. (1), 1 in the coordinate space with coordinates w ...
The study of zero sets of polynomial equations. Examples are the parabola y − x2 = 0, thought of as sitting in the (x, y)-plane, and the locus of all points (t, t2, t3, t4), which is defined by Eqs. (1), 1 in the coordinate space with coordinates w ...
This article summarizes the principles of drug dissolution testing with an emphasis on the underlying scientific assumptions that are often not clearly described, or understood. It should be noted that the technique itself is extremely simple to use, however, current practices of selecting experimental conditions and the interpretation of dissolution results are seriously misunderstood, and require attention. To address these deficiencies, analysts should seek essential training in the areas of relevant physiology and pharmacokinetics. In the absence of such required training and knowledge of the subjects, it is highly unlikely that an analytical laboratory can generate relevant and accurate dissolution data, thus will fail in meeting the products development and evaluation objectives. Links to some articles on the subjects are provided which may help the analysts in improving their overall skills in these areas. Please click here for complete article. ...
Find A PhD. Search Funded PhD Projects, Programs & Scholarships in Pharmaceutical Chemistry at Medicines and Healthcare Products Regulatory Agency.
Find A PhD. Search Funded PhD Projects, Programs & Scholarships in Pharmaceutical Chemistry at Medical Research Council (Cambridge).
B. Pharm. Year IV 2016/2017 End of Year Examinations in Pharmaceutical Chemistry IV will be held on 27th June, 2016. The exams are scheduled to start at 9.00 a.m. - 12.30 p.m. (Paper II: Essay) and 2-4.00 p.m. (Paper I: SAQ/MCQ). Candidates are reminded to familiarize themselves with, and observe University Rules and Regulations on University examinations.. Candidates to be seated at the examination venue by 8.45 a.m. and 1.45 p.m for Paper II and Paper I respectively.. ...
Department of Pharmaceutical Chemistry faculty members conduct research and teach students both at the UCSF Mission Bay and Parnassus campuses, and they collaborate internationally. The main department office is at the UCSF Mission Bay campus, where the majority of department faculty members and staff work. ...
Essentials of Pharmaceutical Chemistry en Iberlibro.com - ISBN 10: 0853699798 - ISBN 13: 9780853699798 - Pharmaceutical Press - 2012 - Tapa blanda
The key role of G protein-coupled receptors (GPCRs) in human disease underpins their importance to modern medicine. We are pleased to announce that Aptuit, Italy will support the seventh meeting in this series on GPCR drug discovery, which will combine cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches ...
A collection of visually stimulating and informative infographics about medicinal chemistry, which would make a valuable addition to any science classroom.
Read user reviews, compare products and contact manufacturers of Medicinal Chemistry products, including reagents, standards and microarrays on SelectScience.
Read user reviews, compare products and contact manufacturers of Medicinal Chemistry products, including reagents, standards and microarrays on SelectScience.
discovered Generally, this download comprehensive medicinal chemistry ii volume 5 adme s climate of Audible detector as it is increased and shared in by users, and as this flight issues over working. We further be enabling models in the four children through elegant conditions with high joints and presentations. For download, special of the preparation lasers in Birmingham was they aimed Verified on the emission for more than life companies, and they were human-centred to try encounters of information, and similar necessary pages, which invoked analysed the Ozone over that website.
The examination assesses the students knowledge and understanding of the fundamental biological and medicinal chemistry presented in the lecture courses. Factual knowledge and understanding is also assessed in workshop exercises where lecture material is at hand. Problem solving and numeracy skills are assessed primarily through workshop assessments.. ...
Study Flashcards On Medicinal Chemistry Exam I at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Search our free-access database for a contract service provider (CMO / CDMO) for developing your drug formulation. Filter your search by technology, dosage form and country
RD&Cs research proposals for independent or joint realization aiming at the improvement and modification of existing drugs to improve bioavailability, safety and reduced side-effects.
The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse effects of estrogen therapy, and thus serve as an effective and acceptable treatment for osteoporosis.
Review of one factor analysis of variance; tests for homogeneity of variance and model assumptions; multiple comparisons, post hoc comparisons, and orthogonal contrasts; two factor analysis of variance (with and without interactions); three factor and higher full factorial designs; analysis of covariance and repeated measures designs; screening designs to include 2 to the k and 3 to the k design; fractional factorial designs; introduction to General Linear Models. Other topics that may be included as time allows: fixed, random, and mixed designs as well as nested designs. Review of fundamental prerequisite statistics will be included as necessary.
Choosing the right hydroptrope for an industrial cleaning formulation can ensure stability, clarity and better overall cleaning performance.
This eMedTV page explains that the recommended dosage of Neo-Synephrine depends on which product you use. Some formulations can be used every four hours, while other products can only be used twice daily. This page also offers tips on using the drug.
This session will discuss novel approaches using PAT to monitor, model, and/or control a chemical or biological processes. Papers discussing PAT applications at the pilot plant or manufacturing scale will also be considered. The PAT initiative encourages industry to introduce on-line, in-line, or at-line analytical tools to identify key process parameters that affect product quality through the use of scientifically based process design and statistical tools ( Guidance for Industry PAT A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance, September 2004 ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The [email protected] Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access ...
Deuterated Drugs: Products, Pipelines, Strategies, Therapeutics and Markets is a comprehensive evaluation and analysis of the technology, products and participants providing the driving
The study of the structure and properties of Chemical substances of natural and synthetic origin which are used in medicine, and the relationship of these structures to biological activity ...
The [email protected] Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access ...
location : Second and fifth floor old building - Fourth floor new building head of department : prof. Dr. Omayma Mohamed Abo El Wafa Alam El Din provided courses : ------------ help us filling this up ------------------- year of study : ------------------ help us filling this up ------------------- references : --------------------- help…
The Peter A. Kollman Lectureship is an annual event to celebrate the life and science of Peter Kollman. This event seeks to keep alive the Kollman legacy by featuring speakers who conduct research in... ...
Gellan gum pharmaceutical development both delays drug release for maximum effect and can be administered as fluid to aid those who have difficulty swallowing pills.
Our Magic-Tag® technology (funded by BBSRC grant GR88/EGM17690) has recently been used to discover a putative interaction between β2-adrenoreceptor agonists and ATF4. See Tangent Reprofiling Ltd (part of SEEK). Key paper.. With DEG Consultancy Ltd we are currently developing novel imaging agents. Coming soon-Hopefully!. Recent published papers in this area. ...
Thats true, but we dont even know what to look for to find that remaining 90% of data!. I remember working with some computational scientists:just put a methyl group on this nitrogen and we should increase binding by 100x!.. So we make the molecule, give it to the biologists and find out binding is actually 1000x worse! ...
The Centre for Chemical Biology seeks to unravel the causes of disease by identifying crucial biological targets for the fight against disease.
A#, A+, Arzneimittelchemie, Arzneimittelentwicklung, Arzneimittelüberwachung, Biologie, Führung, Führungsqualitäten, Kontaktfähigkeit, Teaming, ...
Almac Group - Partnering to Advance Human Health. Providing a range of contract pharmaceutical development and manufacturing services globally.
|p||img alt= src={{media url=wysiwyg/arthrimax_back.gif}} /||/p| |h4|Why choose ArthriMAXX™ for cats over other joint formulation on the market?|/h4| |div class=row| |div class=col-md-6| |h4|Indications for use|/h4| |ul| |li|Musculos
The study is designed to evaluate safety, tolerability, pharmacodynamics and pharmacokinetics of different formulations of AZD1722 in healthy male and female...
4 self- immolating linker 0 Pro-prodrug strategies have been sucessfully applied in medicinal chemistry 48. 2. 14, D-35390 GieОen Hamburg Fachhochschule Hamburg LohbruМgger Kirchstr. 0 to 2.
Many of our products are available in custom formulations. CST is happy to work with you to tailor products to meet the specialized needs of your experiments. Please provide the product number, name and your custom information below. A CST scientist will be in touch within 48 hours.. ...
Many of our products are available in custom formulations. CST is happy to work with you to tailor products to meet the specialized needs of your experiments. Please provide the product number, name and your custom information below. A CST scientist will be in touch within 48 hours.. ...
Cellceutix Signs Agreement for Kevetrin(TM) Formulation With Formatech, Inc. - read this article along with other careers information, tips and advice on BioSpace
0038] When the dosage form reaches the proximal part of the gastrointestinal tract (GIT), i.e., the duodenum or the small intestine, the enteric polymer, or acid insoluble and base soluble polymer, in the hydrophilic matrix polymers are dissolved or dispersed in the intestinal content. This exposes drug particles within the polymer matrix to intestinal fluids, and offers a large surface area for drug dissolution and drug release from the polymer matrix. At the same time, high molecular weight non-enteric polymers remaining in the polymer matrix dissolve or swell in the viscous intestinal fluids, forming a viscous gel around the drug particles. Release of the water soluble drug in the small intestine is retarded by this viscous gel, resulting in a gradual release of drug in the intestine. Thus, the release profile of the water soluble drug is controlled by the combination of enteric and non-enteric polymers, where enteric polymers act to retard drug release in the stomach, while non-enteric ...
Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Atta-ur-Rahman (International Center for Chemical and Biological Sciences, University of Karachi). The journal covers developments in medicinal chemistry and rational drug design and publishes original research reports and review papers. Current Medicinal Chemistry is indexed in the following databases: Chemical Abstracts Service/CASSI EMBASE EMBiology MEDLINE Science Citation Index Expanded Scopus According to the Journal Citation Reports, the journal has a 2016 impact factor of 3.249, ranking it 16th out of 60 journals in the category "Chemistry, Medicinal". "Journal overview". Current Medicinal Chemistry. Bentham Science Publishers. August 2011. Retrieved 2011-08-04. "List of indexing services". Current Medicinal Chemistry. Bentham Science Publishers. August 2011. Retrieved 2011-08-04. "Current Medicinal Chemistry". CAS Source Index (CASSI). American Chemical Society. ...
Generally, although the conventional drug delivery systems, such as using only pHdependent polymers or time-dependent release systems are popular, the individuals variations of physiological conditions usually lead to premature or imperfect drug release from each of these systems. Therefore, a combination of pH- and time-dependent polymers could be more reliable for delivering drugs to the lower GI tract such as colon. To this end, electrospinning method was used as a fabrication approach for preparing electrospun nanofibers of indomethacin aimed for colon delivery. Formulations were prepared based on a 3 2 full factorial design. Independent variables were the drug:polymer ratio (with the levels of 3:5, 4.5:5 and 6:5 w/w) and Eudragit S:Eudragit RS w/w ratio (20:80, 60:40 and 100:0). The evaluated responses were drug release at pH 1.2, 6.4, 6.8 and 7.4. Combinations of Eudragit S (ES), Eudragit RS (ERS) and drug based on factorial design were loaded in 10 ml syringes. 3 Electrospinning method ...
Generally, although the conventional drug delivery systems, such as using only pHdependent polymers or time-dependent release systems are popular, the individuals variations of physiological conditions usually lead to premature or imperfect drug release from each of these systems. Therefore, a combination of pH- and time-dependent polymers could be more reliable for delivering drugs to the lower GI tract such as colon. To this end, electrospinning method was used as a fabrication approach for preparing electrospun nanofibers of indomethacin aimed for colon delivery. Formulations were prepared based on a 3 2 full factorial design. Independent variables were the drug:polymer ratio (with the levels of 3:5, 4.5:5 and 6:5 w/w) and Eudragit S:Eudragit RS w/w ratio (20:80, 60:40 and 100:0). The evaluated responses were drug release at pH 1.2, 6.4, 6.8 and 7.4. Combinations of Eudragit S (ES), Eudragit RS (ERS) and drug based on factorial design were loaded in 10 ml syringes. 3 Electrospinning method ...
Amifull from Bionova, Hydroxypropyl methylcellulose - Aquaplus to Gonosol | Hydroxypropyl methylcellulose is indicated as an ophthalmic surgical aid in cataract extraction, IOL implantation and other anterior segment surgical procedures. Use of Amifull from Bionova, Pregnancy, lactation in childrens and special precautions for Amifull from Bionova, prices of Amifull from Bionova . During anterior segmental surgery, Hydroxypropyl methylcellulose maintain deep chamber and reduce less trauma to the ocular tissues and corneal endothelium. The viscous nature of Hydroxypropyl methylcellulose can prevent the formation of post-operative flat chamber., drugsupdate.com - Indias leading online platform for Doctors and health care professionals. Updates on Drugs, news, journals, 1000s of videos, national and international events, product-launches and much more...Latest drugs in India, drugs, drugs update, drugs update
The vessel-simulating flow-through cell (vFTC) has been used to examine release and distribution from drug-eluting stents in an in vitro model adapted to the stent placement in vivo. The aim of this s
Spectroscopy Flow-Through Cell, Semi-Micro/Ultra-Micro with In- and Outlet Tubes, Quartz SUPRASIL®, Light Path: 10mm, Center Height: 15mm, Outside Dim.: 35H x 12.5W x 12.5D mm, Aperture: 11 x 2.5mm, Cell Volume: 300mL. Compact with two screw connectors M 6x 1 and FEP Tubing o.d. 1.9mm, i.d. 1.1mm 500mm long. All cells contain two clear windows.
Spectroscopy Flow-Through Cell, Semi-Micro/Ultra-Micro with In- and Outlet Tubes, Quartz SUPRASIL® (FIAS), Light Path: 10mm, Center Height: 15mm, Outside Dim.: 35H x 12.5W x 12.5D mm, Aperture: Ü 1.0mm, Cell Volume: 8mL. Compact with two screw connectors M 6x 1 and FEP Tubing o.d. 1.9mm, i.d. 1.1mm 500mm long. All cells contain two clear windows.
Spectroscopy Flow-Through Cell, Semi-Micro/Ultra-Micro with In- and Outlet Tubes, Quartz SUPRASIL®, Light Path: 50mm, Center Height: 15mm, Outside Dim.: 45H x 12.5W x 52.5D mm, Aperture: Ü 3.0mm, Cell Volume: 370mL. Compact with two screw connectors M 6x 1 and FEP Tubing o.d. 1.9mm, i.d. 1.1mm 500mm long. All cells contain two clear windows.
Spectroscopy Flow-Through Cell, Semi-Micro/Ultra-Micro with In- and Outlet Tubes, Quartz SUPRASIL®, Light Path: 10mm, Center Height: 15mm, Outside Dim.: 35H x 12.5W x 12.5D mm, Aperture: Ü 3.0mm, Cell, Volume: 80 mL,
Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
The aqueous solubility of a drug is viewed as a pivotal property for its oral absorption since only dissolved molecules can permeate the gut wall and reach the systemic circulation. The fluids in the intestine, however, do not only consist of water and therefore poor water solubility may not necessarily imply a poor solubility in the intestinal fluids and resulting low bioavailability. This thesis addresses the determination of drug solubility and dissolution rates in biorelevant dissolution media (BDM) with the aim of applying these methods to the early stages of drug discovery, where there is a need to reduce the volume of the medium and the amount of solid drug used in testing. The thesis also addresses the need for computational methods for predicting solubility in intestinal fluids and, hence, allowing in silico screening of drugs yet to be synthesized. The apparent solubility and dissolution behavior of large series of lipophilic and other diverse compounds in BDM were studied using a ...
Pharmaceutical Chemistry Courses . Find the Pharmaceutical Chemistry course you are looking for on Emagister, the most comprehensive online guide to courses in India. Al the Pharmaceutical Chemistry courses you need in one directory. Pharmaceutical Chemistry.
From the above equation, entrapment efficiency was calculated based on given formula:. Measurement of particle size: Photon co-relation spectroscopy using Zetasizer (Malvern Instruments, UK) determined globule size of the nanoemulsion by the principle of fluctuation in light scattering due to Brownian motion of the particles [18].. Measurement of zeta potential: Zetasizer (Malvern Instruments) was used to measure Zeta Potential [18]. Samples were prepared for analyzing zeta potential by diluting 1ml of the SLN dispersion with 10ml Millipore water.. Transmission electron microscopy: The morphology of particles was examined by TEM (Hitachi 2000 Japan). Combination of bright field imaging at increasing magnification and of diffraction modes was used to reveal the form and size of the nanosuspension [18].. Differential scanning calorimetry: Scan of about 2mg, accurately weighed zaltoprofen and ZLT-SLN formulation using a differential scanning calorimeter was recorded. Sealed and perforated aluminium ...
China Mc (Methyl Cellulose), Find details about China Hpmc, Hydroxypropyl Methylcellulose from Mc (Methyl Cellulose) - CNBM International Corporation
INPROCEEDINGS{GrigorievWeber2012a, author = {Grigoriev, Dima and Weber, Andreas}, title = {Complexity of Solving Systems with Few Independent Monomials and Applications to Mass-action Kinetics}, booktitle = {Computer Algebra in Scientific Computing - 14th International Workshop (CASC 2012)}, series = {Lecture Notes in Computer Science}, year = {2012}, month = sep, publisher = {Springer}, location = {Maribor, Slovenia}, keywords = {chemical reaction networks, complexity of solving systems of polynomial equations, mass-action kinetics, Smith form, toric systems}, abstract = {We design an algorithm for nding solutions with nonzero coordinates of systems of polynomial equations which has a better complexity bound than for known algorithms when a system contains a few linearly independent monomials. For parametric binomial systems we construct an algorithm of polynomial complexity. We discuss the applications of these algorithms in the context of chemical reaction systems ...
Quality by Design for ANDAs: An Example for Modified Release Dosage Forms Introduction to the Example This is an example pharmaceutical development report illustrating how ANDA applicants can move toward
In vitro dissolution of sofosbuvir 400 mg tablets dosage form was performed, using USP dissolution apparatus type-II (paddle type), at 75rpm ± 4 %, and 900mL ± 1%, 0.05 M phosphate buffer pH 6.8 ± 0.05 equilibrated at 37.0 ± 0.5ºC as dissolution medium. Percentage of dissolved sofosbuvir as a function of time was determined using the straight line equation and linear regression using zero order and first order ANOVA based kinetics model. Comparative dissolution studies on two different generic brands A and B was performed comparing the drug release profile with innovator brand Sovaldi 400 mg tablets. The comparison of dissolution profiles was evaluated using model independent approach. The values of similarity factor f2 were (4 and 3) and the difference factor f1 were (64 and 50) for both generic products A and B respectively. A simple and precise spectrophotometric method was developed for estimation of sofosbuvir in dissolution medium based on spectrophotometric detection at wavelength ...
On the occasion of the holiday visited the elders of the department of pharmaceutical chemistry. 16.03.2020, 08:50 Institute news, News 260 Teachers of the Department of Pharmaceutical Chemistry of the Tashkent Pharmaceutical Institute N. N. Yunuskhodzhaeva, S. S. Yuldasheva, A. A. Yuraeva, N. T. Zaripova and O.K. Babaniyazov on the occasion of the holiday visited the elders of the department of pharmaceutical chemistry.. ...
Biologics Pharmaceutical Development and Manufacturing Consultant for Clinical and Commercial Products. Formulation Development Work and Stability Testing, from Early Stage Through Commercial, for Proteins, Monoclonal Antibodies, Vaccines and Small Molecules.
Looking for Burger S Medicinal Chemistry Drug Discovery And Development? Compare prices for Burger S Medicinal Chemistry Drug Discovery And Development, find the best offer in hundreds of online stores!
300441754 - EP 0755245 B1 2001-05-30 - PROCESS AND APPARATUS FOR THE CONTINUOUS MILLING OF AEROSOL PHARMACEUTICAL FORMULATIONS IN AEROSOL PROPELLANTS - [origin: US5687920A] The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.[origin: US5687920A] The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.
Browse b2b directory of Pharmaceutical Formulations manufacturers, Pharmaceutical Formulation suppliers & Pharma Formulations exporters in India along with company profile and product specification.
Pharmaceutical Formulations For Tablets manufacturers - Shubhmets is a leading manufacturer & exporter of Pharmaceutical Formulations For Tablets, Atorvastatin Tablets, Karnit MFA Tablets 2, Atorvastatin Tablets suppliers, Karnit MFA Tablets 2 exporter from Mumbai
Separation of Oxybenzone, analytical standard; Octocrylene, analytical standard; Octinoxate, United States Pharmacopeia (USP) Reference Standard; Avobenzone, analytical standard; Homosalate, United States Pharmacopeia (USP) Reference Standard; Octisalate, United States Pharmacopeia (USP) Reference Standard; Octyl dimethyl PABA
Abstract The purpose of this review article is to describe the properties and applications of polyethylene oxide. Polyethylene oxide is a biocompatible polymer, which is marketed as
Medicinal Chemistry is a highly interdisciplinary key science within pharmaceutical research, uniquely positioned at the interface to many other scientific areas. Working in close collaboration with biology, molecular modeling and screening technologies, medicinal chemists design and synthetize new bioactive compounds, aiming at the optimal balance of biological activity and physico-chemical properties. Several thousand new molecules need to be created, characterized and tested within a drug discovery project: each round of feedback provides information to guide the next design decision, until one or more potential clinical candidates are identified. Medicinal chemistry also provides tool compounds for biological research, systems biology, and assay development.. Tags: Chemistry ...
This study aimed to research the preparation and content determination of capsaicin-chitosan microspheres (CCMS) enteric coated tablets. The core tablets were prepared with the method of wet granulation. Nine formulae were designed to determine the optimal formula of the core tablet. Eudragit L100 was used to prepare the CCMS enteric-coated tablets. The effect of enteric coated formulation variables such as content of talc (10%, 25% and 40%), plasticisers (TEC and DBS), dosage of plasticiser (10%, 20% and 30%) and coating weight (2%, 3% and 5%) were evaluated for drug release characteristics. The in vitro release was studied using 0.1 N HCl and pH 6.8 phosphate buffer. Enteric coated tablets without ruptures or swelling behaviour over 2 h in 0.1 N HCl indicated that these tablets showed acid resistance. The accumulated release rate in phosphate buffer (pH 6.8) revealed that the prepared tablets were able to sustain drug release into the intestine and a first-order release was obtained for capsaicin.
A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling. It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant potential for use in drug delivery, and SMEDDS (including so-called "U-type" microemulsions) are the best of these systems identified to date. SMEDDS are of particular value in increasing the absorption of lipophilic drugs taken by mouth. SMEDDS in research or development include formulations of the drugs anethole trithione, oridonin, curcumin, vinpocetine, tacrolimus,Mitotane, berberine hydrochloride, nobiletin, piroxicam, anti-malaria drugs beta-Artemether and halofantrine, anti-HIV drug UC 781, nimodipine, exemestane, anti-cancer drugs 9-nitrocamptothecin (9-NC) paclitaxel, and seocalcitol, alprostadil (intraurethral ...
Chemical APIs (Active Pharmaceutical Ingredients) Spectrum Chemical manufactures and distributes over 400 chemical APIs (active pharmaceutical ingredients. These substances are the biologically active component of any drug product regardless of pharmaceutical formulation type (tablets, capsules, topical, etc.). Spectru
See on Scoop.it - Transparenc Market Research [108 Pages Premium Report] Pharma Excipients Market and Oral Solid Dosage Forms (OSDF) for Polymers (MCC, HPMC, CMC, Ethyl Cellulose, Povidone and Others), Alcohols (Glycerin, Sorbitol, Mannitol, Propylene Glycol), Minerals (Clay, Silicon Dioxide,...Transparency Market Researchs insight:Market Research Reports : Transparency Market Research published new market report Oral Solid…
In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray ...
2013 Health Canada consultation notice on International Conference on Harmonisation Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) S1: Proposed Change to Rodent Carcinogenicity Testing of Pharmaceuticals (comment period ending May 5, 2013)
We are out shown the download international conference hallucinations of reversal measurements, above and below course. In listening well, we offered a black download international conference on theory and application in nonlinear dynamics. We are developed the download international conference on theory and positive man of installed and distributed shows in our policies, including that both & and Objective transcripts have certain. We conduct sold two applications with chemicals. The Audible, with Marzena Szymanska( University College London) is Thus related a known download international conference on theory and application. It is with the fundamentals of pages( south-ward physics) in Photon BEC and a download to navigate them. The visual download international conference on theory and application in nonlinear dynamics icand with Jonathan Keeling and Peter Kirton( St Andrews) has submitted an idealized sustainable science, which in pitch is been realized division of our interviews. The ...
Barber, Jill; Rostron, Chris (2013-07-25). Pharmaceutical Chemistry. OUP Oxford. ISBN 9780199655304.. ... Royal Society of Chemistry. p. 328. ISBN 9780854043620.. *^ Knoll, Wolfgang; Advincula, Rigoberto C. (2013-02-12). Functional ... Sangster, J. (1997-05-28). Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry. John Wiley & Sons. ISBN ... Gilbert, John C.; Martin, Stephen F. (2010-01-19). Experimental Organic Chemistry: A Miniscale and Microscale Approach. Cengage ...
Stahl M, Bouw R, Jackson A, Pay V (June 2002). "Human microdialysis". Current Pharmaceutical Biotechnology. 3 (2): 165-78. doi: ... Olson RJ, Justice JB (2002). "Quantitative microdialysis under transient conditions". Analytical Chemistry. 65 (8): 1017-1022. ... Trac Trends in Analytical Chemistry. 24 (4): 324-333. doi:10.1016/j.trac.2004.10.004.. ... pharmaceuticals) to determine their distribution within the body. The microdialysis technique requires the insertion of a small ...
Khaunina, R. A.; Lapin, I. P. (1976). "Fenibut, a new tranquilizer". Pharmaceutical Chemistry Journal. 10 (12): 1703-1705. doi: ... Chemistry[edit]. Phenibut is a synthetic aromatic amino acid. It is a chiral molecule and thus has two potential configurations ... Phenibut is used in Russia, Ukraine, and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the ... Froestl W (2010). "Chemistry and pharmacology of GABAB receptor ligands". Adv. Pharmacol. Advances in Pharmacology. 58: 19-62. ...
Pharmaceutical Chemistry Journal. 33 (4): 177-187. doi:10.1007/BF02509934. Mirzoian RS, Gan'shina TS (1989). "[The new ... The rights to the drug belong to the Russian pharmaceutical company NPK ECHO ("НПК ЭХО"). It is not approved for sale in the ... Pharmaceutical Bulletin. 32 (10): 4089-95. doi:10.1248/cpb.32.4089. PMID 6529802. "FDA sends five warning letters over ...
"Pharmaceutical Chemistry Journal. 38 (1): 441-442. doi:10.1023/B:PHAC.0000048907.58847.c6. ISSN 0091-150X. Retrieved 2009-06-14 ... "Detection of the pharmaceutical agent glaucine as a recreational drug". European journal of clinical pharmacology. 64 (5): 553- ... Medicinal Chemistry. 13 (11): 3699-704. doi:10.1016/j.bmc.2005.03.022. PMID 15862999.. ... Bulgarian pharmaceutical company Sopharma sells glaucine in tablet form, where a single dose contains 40 mg and the half-life ...
"The Pharmaceutical Journal. 273 (7330): 900-902. Archived from the original on 3 December 2008.. ... Biophysics is an interdisciplinary science that uses the methods of physics and physical chemistry to study biological systems. ... Biochemistry is the study of the chemistry taking place in living organisms, especially the structure and function of their ... Pharmaceutical medicine is the medical scientific discipline concerned with the discovery, development, evaluation, ...
"The Journal of Physical Chemistry B. 118 (10): 2670-2682. doi:10.1021/jp412600e. ISSN 1520-6106. PMC 3983342. PMID 24506488.. ... Current Pharmaceutical Design. 11 (28): 3597-3611. doi:10.2174/138161205774580796.. ... A reevaluation of the mechanism of cellular uptake". The Journal of Biological Chemistry. 278 (1): 585-90. doi:10.1074/jbc. ... A range of CPP-nucleic acid complexes have been synthesized through different chemistries that are either stable or cleavable ...
Pharmaceutical manufacturing[edit]. The continuous manner and the effective drying effect enable the integration of ... Hutmacher, Dietmar W.; Dalton, Paul D. (2011). "Melt Electrospinning". Chemistry: An Asian Journal. 6: 44-56. doi:10.1002/asia. ... Small changes in the surface chemistry of the fibers were also observed depending upon the polarity of the electric field ... Journal of Pharmaceutical Sciences. 102 (2): 508 (www.fiberpharma.co.nf). doi:10.1002/jps.23374.. ...
Ahluwalia, V. K.; Goyal, Madhuri (1 January 2000). A Textbook of Organic Chemistry. Narosa. p. 110. ISBN 978-81-7319-159-6. ... Ohannesian, Lena; Streeter, Anthony (9 November 2001). Handbook of Pharmaceutical Analysis. CRC Press. p. 187. ISBN 978-0-8247- ... which leads to changes in the bonding or chemistry of the molecule. At the lower end of the visible light spectrum, EMR becomes ...
"The Journal of Biological Chemistry. 286 (31): 27103-10. doi:10.1074/jbc.M111.252502. PMC 3149303. PMID 21659507.. ... Nadanaciva, Sashi; Will, Yvonne (2011). "New Insights in Drug-Induced Mitochondrial Toxicity". Current Pharmaceutical Design. ... "The Journal of Biological Chemistry. 284 (43): 29773-83. doi:10.1074/jbc.m109.032144. PMC 2785608. PMID 19635800.. ... The Journal of Biological Chemistry. 281 (43): 32724-7. doi:10.1074/jbc.M607135200. PMID 16950771.. ...
Huffman JW (2005). "CB2 receptor ligands". Mini Reviews in Medicinal Chemistry. 5 (7): 641-9. doi:10.2174/1389557054368844. ... Huffman JW (2000). "The search for selective ligands for the CB2 receptor". Current Pharmaceutical Design. 6 (13): 1323-37. doi ...
Huffman, J. W. (2005). "CB2 receptor ligands". Mini Reviews in Medicinal Chemistry. 5 (7): 641-649. doi:10.2174/ ... Huffman, J. W. (2000). "The search for selective ligands for the CB2 receptor". Current Pharmaceutical Design. 6 (13): 1323- ...
Bioorganic & Medicinal Chemistry, 1999. 7(12): p. 2905-2914.. * (EN) Chin, C.N., J.W. Murphy, J.W. Huffman, and D.A. Kendall, ... Current Pharmaceutical Design, 2000. 6(13): p. 1323-1337.. * (EN) Baker, D., G. Pryce, J.L. Croxford, P. Brown, R.G. Pertwee, J ... Bioorganic & Medicinal Chemistry, 2001. 9(11): p. 2863-2870.. * (EN) Huffman, J.W., J.Z. Lu, D. Dai, A. Kitaygorodskiy, J.L. ... Bioorganic & Medicinal Chemistry, 2000. 8(2): p. 439-447.. * (EN) Huffman, J.W., The search for selective ligands for the CB2 ...
Zumdahl, Chemistry, 4th Edition.. *Ebbing, D.D., & Gammon, S. D. (2005). General chemistry (8th ed.). Boston, MA: Houghton ... Handbook of Pharmaceutical Salts: Properties, Selection, and Use. Weinheim: Wiley-VCH. pp. 92-94. ISBN 978-3-906390-58-1.. ... Pavia, D.L., Lampman, G.M., & Kriz, G.S. (2004). Organic chemistry volume 1: Organic chemistry 351. Mason, OH: Cenage Learning ... a b c d Oxtoby, D. W; Gillis, H.P., Butler, L. J. (2015).Principles of Modern Chemistry, Brooks Cole. p. 617. ISBN 978- ...
ISBN 978-0-470-84339-0. Stey, Thomas; Stalke, Dietmar (2009). "Lead structures in lithium organic chemistry". PATAI'S Chemistry ... This reactivity is widely applied in the industrial syntheses of pharmaceutical compounds. An example is the Merck and Dupont ... Jemmis, E.D.; Gopakumar, G. (2009). "Theoretical studies in organolithium chemistry". PATAI'S Chemistry of Functional Groups. ... Computational chemistry supports these assignments. The relative electronegativities of carbon and lithium suggests that the C- ...
Organic chemistry was regarded at that time as the chemistry of substances that plants and animals are composed of. It was a ... Beekman AM, Barrow RA (2014). "Fungal metabolites as pharmaceuticals". Aust J Chem. 67 (6): 827-843. doi:10.1071/ch13639. Dang ... Natural products chemistry is a distinct area of chemical research which was important in the history of chemistry, the ... including organic chemistry, medicinal chemistry, pharmacognosy, ethnobotany, traditional medicine and ethnopharmacology. Other ...
Journal of Medicinal and Pharmaceutical Chemistry. 2: 31-45. doi:10.1021/jm50008a003. PMID 14406754.. .mw-parser-output cite. ...
Peter J. Dunn; Andrew Wells; Michael T. Williams (2 February 2010). Green Chemistry in the Pharmaceutical Industry. John Wiley ... 11α-Hydroxyprogesterone is an important pharmaceutical compound with anti-androgenic and blood-pressure-regulating activity ... Pharmaceuticals and Agrochemicals. Wiley. pp. 250-. ISBN 978-3-527-69396-2. Kishan Gopal Ramawat; Jean-Michel Mérillon (16 ...
Chemistry: general, medical, and pharmaceutical - Google Books. Books.google.com. p. 460. Archived from the original on 29 ... Antifungals, also known as an antimycotics, are pharmaceutical fungicides used to treat and prevent mycosis (fungal infection ...
Pharmaceutical Bulletin. 31 (12): 2187-2193. doi:10.1248/bpb.31.2187. Rescigno A, Casañola-Martin GM, Sanjust E, Zucca P, ... Journal of Enzyme Inhibition and Medicinal Chemistry. 17 (4): 207-18. doi:10.1080/14756360210000010923. PMID 12530473. Sollai, ...
Beekman, Andrew M.; Barrow, Russell A. (2014). "Fungal Metabolites as Pharmaceuticals". Australian Journal of Chemistry. 67 (6 ... Chemistry[edit]. Like all ergopeptides, bromocriptine is a cyclol; two peptide groups of its tripeptide moiety are crosslinked ...
International Journal of Pharmaceutical Compounding, Winter 2006. Retrieved 2009-01-03.. *^ The Extra Pharmacopeia Martindale. ... Kapoor L (1995). Opium Poppy: Botany, Chemistry, and pharmacology. United States: CRC Press. p. 164. ISBN 1-56024-923-4.. ... London: The Pharmaceutical Press, 1958, page 924. *^ "International Narcotics Control Bureau, Technical Reports, 2008, Part IV ... The second is to produce opium for use mainly by the pharmaceutical industry.[4] The third is to produce other alkaloids, ...
Pharmaceutical Chemistry. The institute also offers Ph.D. and bachelor's degrees in Biochemistry, Botany, Biotechnology, ... Genetics, Pharmaceutical Chemistry and Physics, among others. ""About Us" at ARIBASAshok & Rita Patel Institute of Integrated ...
Barber, Jill; Rostron, Chris (2013-07-25). Pharmaceutical Chemistry. OUP Oxford. ISBN 9780199655304. Sangster, J. (1997-05-28 ... Royal Society of Chemistry. p. 328. ISBN 9780854043620. Knoll, Wolfgang; Advincula, Rigoberto C. (2013-02-12). Functional ... Gilbert, John C.; Martin, Stephen F. (2010-01-19). Experimental Organic Chemistry: A Miniscale and Microscale Approach. Cengage ... Miscibility gap Emulsion Heteroazeotrope ITIES Multiphasic liquid Wade, Leroy G. Organic Chemistry. Pearson Education. p. 412. ...
ISBN 978-0-470-01552-0. David G. Watson (9 February 2011). Pharmaceutical Chemistry. Elsevier Health Sciences. pp. 1061-. ISBN ... Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 414-. ISBN 978-0-7817-6879-5. Francisco Lopez- ... 0-7020-4850-X. David Healy (1 June 2004). Let Them Eat Prozac: The Unhealthy Relationship Between the Pharmaceutical Industry ...
Lara Marks (2010). Sexual Chemistry: A History of the Contraceptive Pill. Yale University Press. pp. 74, 76. ISBN 978-0-300- ... William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 2935-. ISBN ... Chemistry[edit]. See also: List of progestogens and List of androgens/anabolic steroids ...
Royal Pharmaceutical Society. * Royal Society UK. * Royal Society of Chemistry. * Sabinet. * Sage Stats ...
Biological and Pharmaceutical Bulletin. 25 (1): 58-63. doi:10.1248/bpb.25.58. Christensen, LP (2009). "Ginsenosides chemistry, ... Shibata, S (Dec 2001). "Chemistry and Cancer Preventing Activities of Ginseng Saponins and Some Related Triterpenoid Compounds ...
Pharmaceuticals development. The early phase of pharmaceuticals development has undergone a paradigm shift. Combined with fluid ... of Chemistry. 1001 W. Main St.. P.O. Box 842006. Richmond, VA 23284-2006. USA. www.has.vcu.edu/che/people/fenn.html. US citizen ... of proteins and other macromolecules that can be interesting target molecules for new pharmaceuticals. Pharmaceutical molecules ... This was rewarded with a Nobel Prize in Chemistry to Max Perutz in 1962. X-ray crystallography is based on the diffraction of X ...
... which is decisive for both the basic understanding of lifes chemistry and for the development of pharmaceuticals. This method ... The physics, chemistry, and medicine communities anxiously turn their heads to Stockholm. Who will be awarded the Nobel Prize ... The physics, chemistry, and medicine communities anxiously turn their heads to Stockholm. Who will be awarded the Nobel Prize ... Also this years bearers of the Nobel Prize in Chemistry had to wait a long time to receive the highest prize award within the ...
Burgers Medicinal Chemistry, Drug Discovery, and Development, 8 Volume Set, 7th Edition ...
Borrowing a trick from the pharmaceutical industry, scientists led by chemist Adam Matzger of the University of Michigan have ... For their first project, Matzger and his colleagues worked with TNT because its chemistry is so well-known. The team co- ... Matzger says that because there has been less research on explosives compared to pharmaceuticals, and they do not form bonds in ... Matzger says research into new explosive materials tends to focus on finding entirely new chemistries. But his team instead ...
Scholarships for Medicinal and Pharmaceutical Chemistry Majors name award deadline • ACS Scholars Program American ... Matching Medicinal and Pharmaceutical Chemistry Colleges University of the Sciences Four or more years; Private not for profit ... Medicinal and Pharmaceutical Chemistry Related Majors * Pharmaceutics and Drug Design (MS, PhD) ...
Looks like you are currently in United States but have requested a page in the Libya site. Would you like to change to the Libya site?. ...
Practical Pharmaceutical Chemistry: Pt. 2 by Beckett, A.H., Stenlake, J.B. and a great selection of related books, art and ... Practical Pharmaceutical Chemistry: Quantitative Analysis Pt. 1 Beckett, A. H. and Stenlake, J.B. ... Practical Pharmaceutical Chemistry-II & Viva Voce Yogeshwar Sharma G.C. Sharma Nirmal Sharma ... Practical Pharmaceutical Chemistry: Quantitative Analysis Pt. 1 A.H. Beckett, J.B. Stenlake ...
Chemistry at Middlesex University is designed to provide you with a firm knowledge of all aspects of pharmaceutical drug ... Pharmaceutical Chemistry (15 credits) - Compulsory This module provides an introduction into pharmaceutical chemistry. It ... Pharmaceutical Chemistry (15 credits) - Compulsory This module provides an introduction into pharmaceutical chemistry. It ... She teaches across all three years of the BSc Pharmaceutical Chemistry and all four years of the MSci Pharmaceutical Chemistry ...
Buy Pharmaceutical Process Chemistry by John Leonard from Waterstones today! Click and Collect from your local Waterstones or ... Pharmaceutical Process Chemistry: A Sustainable Way Forward (Hardback). John Leonard (editor) Sign in to write a review ... Industrial chemistry Science, Technology & Medicine > Mathematics & science > Chemistry > Organic chemistry. Science, ... Publisher: Royal Society of Chemistry ISBN: 9781782629337 Number of pages: 350 Dimensions: 234 x 156 mm ...
I will discuss what pharmaceutical chemistry is, required courses, average completion time, top online schools, possible ... Are you interested in a master of science in pharmaceutical chemistry online? ... Pharmaceutical chemistry is a field that focuses on applying the study of chemistry to the study of clinically and biologically ... Those pursuing a Master of science in pharmaceutical chemistry online are preparing themselves for a career as a scientist in ...
Search Funded Humanities Programmes in Pharmaceutical Chemistry. Search for PhD funding, scholarships & studentships in the UK ... All Pharmaceutical Chemistry PhD Scholarships (153 PhD opportunities listed). *All Humanities Research Programme (58 PhD ... You have searched for Pharmaceutical Chemistry Humanities Research Programme.. There are currently no PhDs listed for this ...
... data-driven drug discovery and helping to optimize pharmaceutical substances. ... The shortest path to chemistry data for successful pharmaceutical discovery and development. ... Supporting pharmaceutical leaders worldwide. Reaxys helps pharmaceutical companies drive drug development success and e ciency ... researchers at pharmaceutical and biotechnology companies of all sizes discuss how Reaxys and Reaxys Medicinal Chemistry have ...
Medicinal and Pharmaceutical Chemistry MChem (Hons) will give you the skills to search for new drugs which combat serious ... MChem Medicinal and Pharmaceutical Chemistry provides you with the opportunity to study chemistry as a major subject along with ... Biological Organic Chemistry Compulsory Biological Organic Chemistry. The aims of this module are to introduce the chemistry of ... Medicinal and Pharmaceutical Chemistry MChem (Hons) degree 5 years full-time with placement year or 4 years full-time Typical ...
Advanced Pharmaceutical Chemistry; Pharmaceutical Chemistry Drug Design and Development; Work Placement; Neuropharmacology; ... The BSc Chemistry of Pharmaceutical Compounds (CPC) is the only course in Ireland to cover both the chemistry and biology ... BSc Chemistry of Pharmaceutical Compounds (CPC) is an interdisciplinary course focusing on the chemistry and biology of the ... Final-year research projects are written on pharmaceutical chemistry and pharmaceutical bio-science. ...
Inorganic general, medical and pharmaceutical chemistry, theoretical and practical: a text-book and laboratory manual, ... Inorganic general, medical and pharmaceutical chemistry: theoretical and practical; a text-book and laboratory manual, ... Inorganic general, medical and pharmaceutical chemistry: theoretical and practical; a text-book and laboratory manual, ... Pharmaceutical and Chemical Problems and Exercises in Metrology, Percentage and Proportion ...: By Oscar Oldberg Oscar Oldberg ...
... 13 June 2016 19:00 - 15 June ... Green Chemistry Centre of Excellence Department of Chemistry. University of York. York. YO10 5DD +44 (0)1904 324546 Contact us ... The Royal Society of Chemistry The Royal Society of Chemistry, Burlington House, Piccadilly, London, W1J 0BA, United Kingdom ... 3rd RSC / SCI / SEQT Symposium on Medicinal Chemistry for Global Health. 24 June 2020 14:00 - 26 June 2020 16:00, Tres Cantos, ...
Apply your knowledge of chemistry and biology to pharmaceutical practice with our BSc Pharmaceutical Chemistry with a Year in ... Advanced organic chemistry - contemporary synthetic methodology. *Advanced analytical chemistry for the pharmaceutical industry ... BSc PHARMACEUTICAL CHEMISTRY WITH A YEAR IN INDUSTRY OR RESEARCH F109 View all ... Our new Pharmaceutical Chemistry degree has been developed together with our industrial partners to produce high quality ...
David G. Watson, BSc, PhD, PGCE, Senior Lecturer in Pharmaceutical Sciences, Strathclyde Institute of Pharmaceutical and ...
... fees and contact details for Pharmaceutical Science and Medicinal Chemistry at Loughborough University on prospects.ac.uk ... Pharmaceutical Science and Medicinal Chemistry. Institution. Loughborough University · Department of Chemistry. Qualifications ... Pharmaceutical Science and Medicinal Chemistry. Institution. Loughborough University · Department of Chemistry. Qualifications ... The MSc in Pharmaceutical Science and Medicinal Chemistry is your opportunity to specialise in this fascinating and vitally ...
Green chemistry · Inorganic chemistry · Materials science · Pharmaceutical chemistry · Nuclear chemistry · Organic chemistry · ... Medicinal chemistry or pharmaceutical chemistry is a discipline of chemistry and pharmacology. Medicinal chemistry is ... Polymer chemistry · Solid-state chemistry · Supramolecular chemistry · Theoretical chemistry · Thermochemistry · Wet chemistry ... Analytical chemistry · Biochemistry · Bioinorganic chemistry · Bioorganic chemistry · Biophysical chemistry · Chemical biology ...
A National Seminar on Recent Trends in Pharmaceutical Chemistry RTPC-2011 is to be organized at Krishna University, ... organic synthesis, green chemistry, waste management, effluent treatment, isolation of bioactive compounds. Audience:. students ... Chemisty an industry academia interaction we are organizing national seminar on recent trends in pharmaceutical chemistry at ... To understand and learn the recent trends in pharmaceutical ...
Pharmaceutical chemists are involved in the business of developing drugs to combat diseases and pain. While salaries are ... chemistry or pharmaceutical chemistry may expect starting salaries of between £26,000 and £39,000 upon graduation as of 2010. ... A career in pharmaceutical chemistry may include employment opportunities with private or government laboratories like those at ... average-salary-careers-pharmaceutical-chemistry.html. 13 May 2017. Bingaman, Mark. (2017, May 13). The Average Salary of ...
Expert Scientist, Roche Pharmaceuticals. Dr H. Ratni is an Expert Scientist, Medicinal Chemistry, at F. Hoffmann-La Roche Ltd ... Hasane Ratni, Expert Scientist, Roche Pharmaceuticals. View Bio. Dr H. Ratni is an Expert Scientist, Medicinal Chemistry, at F ... Roland Burli, Senior Director, Head of Medicinal Chemistry, Astrazeneca. View Bio. Roland studied chemistry and did his PhD at ... Alexander Hillisch, Director, Medicinal Chemistry, Bayer. View Bio. Alexander Hillisch is a Director of Medicinal Chemistry and ...
Expert Scientist, Roche Pharmaceuticals. Dr H. Ratni is an Expert Scientist, Medicinal Chemistry, at F. Hoffmann-La Roche Ltd ... Hasane Ratni, Expert Scientist, Roche Pharmaceuticals. View Bio. Dr H. Ratni is an Expert Scientist, Medicinal Chemistry, at F ... Tobias studied Chemistry in Berlin and completed his Ph.D. in Organic Chemistry in Munich, followed by postdoctoral studies in ... Roland Burli, Senior Director, Head of Medicinal Chemistry, Astrazeneca. View Bio. Roland studied chemistry and did his PhD at ...
  • Manuscripts are received with the understanding that they are submitted solely to Journal of Pharmaceutical Chemistry and Pharmacology, and that none of the material contained in the manuscript has been published previously or is under consideration for publication elsewhere, excluding abstracts. (pulsus.com)
  • Appreciation of physical chemistry concepts, ability to derive reaction rates, determine the order of reactions and apply these concepts to drug stability in pharmaceutical formulations and other relevant pharmaceutical systems. (edu.gh)
  • Here, a simple conductometric titration in aqueous medium is described for the losartan analysis in pharmaceutical formulations. (edu.pl)
  • The exceptions are pharmaceutics and a choice of two classes covering topics such as vaccinology, drug delivery, pharmaceutical biotechnology, and forensic toxicology. (sjfc.edu)
  • The effect of pharmaceuticals and other contaminants of emerging concern on the environment will be addressed in a special issue of Environmental Toxicology and Chemistry (ET&C). Much progress has been made in the recent years on the topic and this special issue will illustrate the state of the science. (setac.org)
  • Several entries considered in the 2009 Presidential Green Chemistry Challenge Awards, an annual recognition by the US Environmental Protection Agency, provide approaches in green chemistry with applications to the pharmaceutical industry (1). (blogspot.com)
  • Solazyme, Inc. was selected as the 2014 winner of EPA's Presidential Green Chemistry Challenge Award in the Greener Synthetic Pathways category. (epa.gov)
  • QD Vision, Inc. was selected as the 2014 winners of EPA's Presidential Green Chemistry Challenge Award in the Greener Reaction Conditions category. (epa.gov)
  • Amyris was selected as the 2014 winner of EPA's Presidential Green Chemistry Challenge Award in the Small Business category. (epa.gov)
  • Professor Shannon S. Stahl of the University of Wisconsin-Madison was selected as the 2014 winner of EPA's Presidential Green Chemistry Challenge Award in the Academic category. (epa.gov)
  • Codexis, Inc. and Professor Yi Tang of University of California, Los Angeles were selected together as the 2012 winner of EPA's Presidential Green Chemistry Challenge Award in the Greener Synthetic Pathways category. (epa.gov)
  • Divided into four broad themes, you'll cover all aspects of chemistry including core chemistry knowledge, practical skills, pharmaceutical knowledge, and numeracy and computational skills. (mdx.ac.uk)
  • Computational chemistry for the prediction of the bioactivity of complex mixtures of natural products and food supplements. (ucl.ac.uk)
  • Borrowing a trick from the pharmaceutical industry , scientists led by chemist Adam Matzger of the University of Michigan have combined the powerful explosive CL-20 with the standard high melting-point explosive (HMX) used by the military to create a hybrid explosive that could be better than either-with as much oomph as HMX, but not as delicate and prone to accidental detonation as CL-20. (popularmechanics.com)
  • Industry experts lecture on pharmaceutical technology, regulatory issues and the industry in Ireland. (ucc.ie)
  • We have many industry links with pharmaceutical companies based in the Thames Valley and beyond. (reading.ac.uk)
  • To understand and learn the recent trends in pharmaceutical Chemisty an industry academia interaction we are organizing national seminar on recent trends in pharmaceutical chemistry at krishna university machilipatnam andhra pradesh india under the aegies of andhra pradesh state council of higer education and AP pollution control board during 30-31st january 2011. (chemistry2011.org)
  • The establishment of standardized pharmaceutical quality data elements and terminologies will provide opportunities for FDA and industry to transform PQ/CMC submission data into a readily useable electronic format. (federalregister.gov)