Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.

An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)

The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.

A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.

Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.

A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Chemicals that are used to cause the disturbance, disease, or death of humans during WARFARE.

Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.

Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.

Databases devoted to knowledge about specific chemicals.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.

An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.

Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

The rate dynamics in chemical or physical systems.

The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.

A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.

Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.

The use of chemical agents in TERRORISM. This includes the malevolent use of nerve agents, blood agents, blister agents, and choking agents (NOXAE).

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.

Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.

The characteristic three-dimensional shape of a molecule.

Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.

Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.

Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.

The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

The relationship between the dose of an administered drug and the response of the organism to the drug.

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

Elements of limited time intervals, contributing to particular results or situations.

Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.

Separation of a mixture in successive stages, each stage removing from the mixture some proportion of one of the substances, for example by differential solubility in water-solvent mixtures. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.

The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The study of ENVIRONMENTAL POLLUTION and the toxic effects of ENVIRONMENTAL POLLUTANTS on the ECOSYSTEM. The term was coined by Truhaut in 1969.

A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.

The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.

The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.

Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.

The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

The process of cleaving a chemical compound by the addition of a molecule of water.

Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.

The process of finding chemicals for potential therapeutic use.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Characteristics or attributes of the outer boundaries of objects, including molecules.

Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

Presence of warmth or heat or a temperature notably higher than an accustomed norm.

Adverse effect upon bodies of water (LAKES; RIVERS; seas; groundwater etc.) caused by CHEMICAL WATER POLLUTANTS.

Established cell cultures that have the potential to propagate indefinitely.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

Chemical substances, excreted by an organism into the environment, that elicit behavioral or physiological responses from other organisms of the same species. Perception of these chemical signals may be olfactory or by contact.

The reactions and interactions of atoms and molecules, the changes in their structure and composition, and associated energy changes.

The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.

The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.

Mixtures of many components in inexact proportions, usually natural, such as PLANT EXTRACTS; VENOMS; and MANURE. These are distinguished from DRUG COMBINATIONS which have only a few components in definite proportions.

A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

The study of existing genetic knowledge, and the generation of new genetic data, to understand and thus avoid DRUG TOXICITY and adverse effects from toxic substances from the environment.

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.

Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.

A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.

The sum of the weight of all the atoms in a molecule.

The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.

Computer-based representation of physical systems and phenomena such as chemical processes.

Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.

The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Proteins found in any species of bacterium.

Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).

Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.

Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.

Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The study of the composition, chemical structures, and chemical reactions of living things.

The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.

A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)

A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

The above-ground plant without the roots.

Compounds containing the -SH radical.

Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.

Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.

The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The chemical and physical integrity of a pharmaceutical product.

The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.

Organic compounds containing a carbonyl group in the form -CHO.

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.

A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.

A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.

Waste products which threaten life, health, or the environment when improperly treated, stored, transported, disposed of, or otherwise managed.

Pheromones that elicit sexual attraction or mating behavior usually in members of the opposite sex in the same species.

The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.

Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)

An essential amino acid. It is often added to animal feed.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

An antiseptic and disinfectant aromatic alcohol.

A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.

Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.

Proteins prepared by recombinant DNA technology.

A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.

Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.

Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.

Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.

Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.

Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).

Worthless, damaged, defective, superfluous or effluent material from industrial operations.

The spectrometric analysis of fluorescent X-RAYS, i.e. X-rays emitted after bombarding matter with high energy particles such as PROTONS; ELECTRONS; or higher energy X-rays. Identification of ELEMENTS by this technique is based on the specific type of X-rays that are emitted which are characteristic of the specific elements in the material being analyzed. The characteristic X-rays are distinguished and/or quantified by either wavelength dispersive or energy dispersive methods.

Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.

The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.

Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)

A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.

Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.

Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)

Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.

Non-steroidal compounds with estrogenic activity.

An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.

Relating to the size of solids.

Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.

A class of compounds composed of repeating 5-carbon units of HEMITERPENES.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

... is a bimonthly peer-reviewed medical journal that publishes full-length research papers, review ... "Drug and Chemical Toxicology". 2020 Journal Citation Reports. Web of Science (Science ed.). Clarivate. 2021. Official website ( ...

16 The drug cyproterone acetate has been commonly used for chemical castration throughout Europe. It resembles the drug MPA ... The drug has thereafter become a mainstay of chemical castration in America. Despite its long history and established use, the ... Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or ... Leuprolide acetate is an LHRH agonist that is most commonly used in chemical castration today. This drug has been observed as ...

"Chemical Probes Versus Drugs". In the Pipeline. Retrieved 27 July 2015 - via Science Translational Medicine. (Chemical biology) ... In the field of chemical biology, a chemical probe is a small molecule that is used to study and manipulate a biological system ... 2015). "The promise and peril of chemical probes". Nature Chemical Biology. 11 (8): 536-41. doi:10.1038/nchembio.1867. PMC ... Chemical Probes Portal Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, et al. ( ...

including cytotoxic and cytostatic drugs. Bavla and Naroda (Ahmedabad), India: Dishman Pharmaceuticals and Chemicals Ltd. The ... specialty chemicals and phase transfer catalysts. Dishman operates in four business units: Dishman Specialty Chemicals, which ... active pharmaceutical ingredients and fine chemicals. Shanghai, China: Dishman Pharmaceuticals and Chemicals (Shanghai) Co., ... Dishman Vitamins and Chemicals, which manufactures vitamin D2, vitamin D3, vitamin D analogs, cholesterol and lanolin related ...

... s are used in areas such as virtual library generation in drug design, in molecular design with ... In a chemical graph, the maximum degree of an atom is its valence, and the maximum number of bonds a chemical element can make ... A chemical graph generator is a software package to generate computer representations of chemical structures adhering to ... Although chemical mixtures are one of the main interests of many chemists, due to the computational explosion, many structure ...

11, 48-56 [9]. Ma, H. and Horiuchi, K.Y. (2006) "Chemical Microarray: a new tool for drug screening and discovery", Drug ... Drug Discov". Today 9, 358-365. Gosalia, DN and Diamond, SL. (2003) "Printing Chemical libraries on microarrays for fluid phase ... A chemical compound microarray is a collection of organic chemical compounds spotted on a solid surface, such as glass and ... In chemical genetics research, they are routinely used for searching proteins that bind with specific chemical compounds, and ...

Quality Chemicals Limited (QCL) convinced Indian drug maker Cipla to go into a joint venture with QCL and the government of ... Cipla also owns 51 percent of Quality Chemicals Limited. Up until May 2015 Quality Chemicals Limited owned 22.05 percent of ... Cipla Quality Chemical Industries Limited (21 May 2019). "Cipla Quality Chemical Industries Limited: Audited Financial ... "Investment Partners in Cipla Quality Chemical Industries Limited". Kampala: Cipla Quality Chemical Industries Limited ( ...

... for veterinary drugs follow in importance. The production value for fine chemicals used for specialty chemicals other than ... Chemical industry Commercial classification of chemicals Commodity chemicals Petrochemical Speciality chemicals Pollak, Peter ( ... The fine chemical industry has a keen interest in the top-selling or "blockbuster drugs", i.e. those with worldwide annual ... The term "fine chemicals" was in use as early as 1908. The emergence of the fine chemical industry as a distinct entity dates ...

Drug precursors, also referred to as precursor chemicals or simply precursors, are substances which are known to be used in the ... "Asia biggest source and market for precursor chemicals used to make illicit drugs" (Web Story). UNODC Southeast Asia and ... Drug culture, Drug-related lists, Illegal drug trade). ... However, while the chemical and pharmaceutical industries of ... Act DEA list of chemicals European law on drug precursors United Nations Convention Against Illicit Traffic in Narcotic Drugs ...

A new chemical entity (NCE) is, according to the U.S. Food and Drug Administration, a novel, small, chemical molecule drug that ... Molecular/chemical entity Medicinal chemistry Drug development "Archived copy" (PDF). Food and Drug Administration. Archived ... Under the Food and Drug Administration Amendments Act of 2007, all new chemical entities must first be reviewed by an advisory ... United States Food and Drug Administration. 1 April 2018. Retrieved 15 February 2019. NME's worldwide and in Germany CDER Drug ...

Sneader, Walter (2005). Drug discovery: a history. Wiley. ISBN 0-471-89979-8. Strudwick, J. P.; Mark Pottle (2004). "Chambers, ... Imperial Chemical Industries (ICI) was a British chemical company. It was, for much of its history, the largest manufacturer in ... The subsidiary ICI New Zealand provided substantial quantities of chemical products - including swimming pool chemicals, ... In 1997, ICI acquired National Starch & Chemical, Quest International, Unichema, and Crosfield, the speciality chemicals ...

While chemical probes can be valuable tools to elucidate signal transduction pathways and to validate new drug targets, many of ... Chemical Probes". "Scientific Advisory Board - Chemical Probes". "Earning Portal Endorsement - Chemical Probes". "Chemical ... Workman P. "Ensuring biomedical research is gold standard - through better use of chemical probes". The Drug Discoverer blog. ... The Chemical Probes Portal is an open, online resource whose purpose is to identify and make available high quality chemical ...

"The value of chemical genetics in drug discovery". In Folkers G, Kubinyi H, Müller G, Mannhold R (eds.). Chemogenomics in drug ... Phenotypic screening of chemical libraries is used to identify drug targets (forward genetics or chemoproteomics) or to ... Chemoproteomics Chemical biology Chemogenomics Kubinyi H (2006). "Chemogenomics in drug discovery". In Weinmann H, Jaroch S ( ... O'Connor CJ, Laraia L, Spring DR (Aug 2011). "Chemical genetics". Chemical Society Reviews. 40 (8): 4332-45. doi:10.1039/ ...

"Small Molecule Drug Discovery // Drug Development". "BIOVIA Chemical Registration - BIOVIA - Dassault Systèmes®". "Register". " ... A chemical database is a database specifically designed to store chemical information. This information is about chemical and ... MCS is also used for screening drug like compounds by hitting molecules, which share common subgraph (substructure). Chemicals ... Chemical structures are traditionally represented using lines indicating chemical bonds between atoms and drawn on paper (2D ...

ISBN 978-0-312-37265-1. "Chemicals, Drugs & Potions > Tek (TekWar)". Tv Acres. Retrieved 2011-04-02. "Tek Headz". Net.saipan. ... The drug creates a simulated reality (and in the films and TV series taps into "the matrix" hyperspace). In the later novels, a ... The 22nd century universe is centered on "Tek"-an illegal, addictive, mind-altering digital drug in the form of a microchip. ... is a former police officer framed for dealing the drug four years prior to the start of the first novel. Having been sentenced ...

Armaments L65 Chemicals • Rubber • Drugs • Biotechnology • Plastics L66 Food • Beverages • Cosmetics • Tobacco • Wine and ...

Hans-Werner V (2005). "Neoantigen-Forming Chemicals". Encyclopedic Reference of Immunotoxicology. p. 475. doi:10.1007/3-540- ... Drug Discovery Today. 25 (6): 1034-1042. doi:10.1016/j.drudis.2020.03.006. PMID 32205198. S2CID 214629963. ...

ISBN 0-87341-832-8. "Federal Food, Drug, and Cosmetic Act". US Food and Drug Administration. "Food Chemicals Codex". United ... "Food Chemicals Codex". "FD&C Act Chapter IV: Food". US Food and Drug Administration. 3 November 2018. Ayres, Chris (27 February ... In Mexico, a man who worked for drug cartels admitted to having disposed of more than 300 bodies with it. A 3-10% solution of ... In the United States, food-grade lye must meet the requirements outlined in the Food Chemicals Codex (FCC), as prescribed by ...

"Mercaptobenzothiazole". drugs.com. T. Sorahan (April 2009). "Cancer risks in chemical production workers exposed to 2- ... Chris Graham (February 28, 2016). "Chemical found in babies' dummies and condoms 'probably causes cancer'". The Telegraph. ... Ash, Michael (2004). Handbook of Green Chemicals. ISBN 9781890595791. "2 Mercaptobenzothiazole (MBT) Uses". 25 June 2019. " ... Chemicals and Additives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a23_365. ...

Specialty Chemicals 4. Organic Chemicals Synthesis 5. Drugs 6. Cosmetic Chemicals 7. Food Additives 8. Agricultural Chemicals 9 ... Military Purpose Chemicals 11. Electro Chemicals 12. Inorganic Chemicals 13. Industrial Chemicals And Additives 14. ... Photographic Chemicals 15. Industrial Cleaning And Protection Chemicals 16. R & D And Laboratory Chemicals 17. Corrosion ... Chemical companies established in 1986, Chemical companies of Turkey, Manufacturing companies based in Ankara, Turkish ...

Goldberg DR (Summer 2009). "Aspirin: Turn of the Century Miracle Drug". Chemical Heritage Magazine. 27 (2): 26-30. Archived ... Lewis Sr RJ (2008). Hazardous Chemicals Desk Reference. John Wiley & Sons. p. 1217. ISBN 9780470334454. "Salicylic acid". Drugs ... Kaiser Permanente Drug Encyclopedia. Accessed 28 Sept 2011. Madan RK, Levitt J (April 2014). "A review of toxicity from topical ... "Low salicylate diet". Drugs.com. 19 February 2019. Archived from the original on 16 December 2019. Retrieved 16 December 2019. ...

... and Chemicals and drugs. According to a report by the Office of the Chief Economist at Global Affairs Canada, ratification of ... "prevent drug regulatory agencies such as the Food and Drug Administration from registering a generic version of a drug for a ... The article argues that the provisions in the TPP concerning generic drugs directly target India's pharmaceutical industry. ... Additionally, they worried that the TPP would not be flexible enough to accommodate existing non-discriminatory drug ...

Chemicals; Rubber; Drugs; Biotechnology JEL: L66 - Food; Beverages; Cosmetics; Tobacco; Wine and Spirits JEL: L67 - Other ...

J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp ... "Drugs@FDA: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 16 November 2016. Muller (19 June ... ISBN 978-94-009-4145-8. "Drugs@FDA: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 26 July ... "Estradiol". Drugs.com. Richard J. Lewis (13 June 2008). Hazardous Chemicals Desk Reference. John Wiley & Sons. pp. 594-. ISBN ...

"1-methylpiperazine". European Chemicals Agency. Vardanyan, Ṛuben & Hruby, Victor J. Synthesis of Essential Drugs. p. 226.{{cite ... For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, meclizine, and ... Indian Journal of Chemical Technology. 1 (November): 359-360. 1994. (CS1 maint: multiple names: authors list, Articles without ... Articles containing unverified chemical infoboxes, Chembox image size set, Articles with short description, Short description ...

... estimate chemical diversity and predict drug target. Recently, 3D chemical similarity networks based on 3D ligand conformation ... Chemical similarity (or molecular similarity) refers to the similarity of chemical elements, molecules or chemical compounds ... "Daylight Chemical Information Systems Inc". Archived from the original on 2012-03-22. Retrieved 2022-07-19. "Barnard Chemical ... In general terms, function can be related to the chemical activity of compounds (among others). The notion of chemical ...

A chemical patent, pharmaceutical patent or drug patent is a patent for an invention in the chemical or pharmaceuticals ... "Milestones in U.S. Food and Drug Law History". U.S. Food and Drug Administration. Retrieved August 11, 2019. European ... In the pharmaceutical industry, the patent protection of drugs and medicines is accorded a particular importance, because drugs ... A chemical patent or a pharmaceutical patent is therefore not a sui generis right, i.e. a special legal type of patent. ...

Food and Drug Administration (FDA) for use as chemical restraints. Drugs that are often used as chemical restraints include ... A chemical restraint is a form of medical restraint in which a drug is used to restrict the freedom or movement of a patient or ... Chemical restraint is also referred to as a "Psychopharmacologic Agent", "Psychotropic Drug" or "Therapeutic Restraints" in ... Patients can view chemical restraint as a violation of integrity and find the experience traumatic. "Chemical restraint, also ...

For foodborne illness caused by chemicals, see Food contaminants. "Chemicals, Metals & Pesticides in Food". Food and Drug ... Furthermore, foodborne illness can be caused by a number of chemicals, such as pesticides, medicines, and natural toxic ... In August 2006, the United States Food and Drug Administration approved phage therapy which involves spraying meat with viruses ... The term mycotoxin is usually reserved for the toxic chemical products produced by fungi that readily colonize crops. ...

... drugs and chemicals. Some details of the secretive Q Branch and some of its members are included. In the February 1984 edition ...

90% of the world's star anise crop is used in the manufacture of Tamiflu, a drug used to treat avian flu. Starch sodium ... The Japan Food Chemical Research Foundation. Food Additive Status List , FDA Australian Food Additive Codes Portal: Food ( ... flavor enhancer Food Chemicals Codex List of additives in cigarettes List of food additives, Codex Alimentarius List of ...

On the West Coast, author Ken Kesey, a prior volunteer for a CIA-sponsored LSD experiment, also advocated the use of the drug. ... After taking psilocybin, a psychoactive chemical produced by certain mushrooms that causes effects similar to those of LSD, ... He often invited friends as well as an occasional graduate student to consume such drugs along with him and colleague Richard ... However, as a result, crime increased among users because new laws were subsequently enacted to control the use of both drugs. ...

Drugs missing an ATC code, Articles containing unverified chemical infoboxes, Bromoarenes, Designer drugs, Psychedelic ... v t e (Articles with short description, Short description matches Wikidata, Drugs with non-standard legal status, Infobox drug ... 2C-B-DRAGONFLY (2C-B-DFLY) is a recreational designer drug with psychedelic effects. It can be regarded as the fully aromatic ... articles with non-default infobox title, Articles without EBI source, Chemical pages without ChemSpiderID, Chemical pages ...

"Germany lifts Leipold drug ban". CBC Sports. CBC. 26 January 2001. Retrieved 20 August 2010. Schulze, Katrin (28 December 2009 ... American Chemical Society. Retrieved 20 August 2010. "Wrestling Database". BIKILA. Archived from the original on 19 August 2010 ... "GC/MS Drug Testers Face Olympian Challenge - Analytical chemists check athletes for more than 150 illegal substances". Today's ...

Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, Alkaloids found in ... CS1 Chinese-language sources (zh), Articles with short description, Short description matches Wikidata, Chemical pages without ... Chemical constituents from air-dried Piper longum]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of ... Potential Leads for Drug Discovery and Development". Evidence-Based Complementary and Alternative Medicine. 2015: 238482. doi: ...

Journal of the American Chemical Society. 132 (47): 17023-31. doi:10.1021/ja107806j. PMC 3012390. PMID 21067187. Wang GP, ... monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design". Structure. 16 (1): 82-92. ...

List of androgen esters § Nandrolone esters Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, ... Chemical pages without DrugBank identifier, Articles without KEGG source, Drugs missing an ATC code, Drugs with no legal status ... Genito-urinary system drug stubs, Gastrointestinal system drug stubs, Steroid stubs). ... 660-. ISBN 978-1-4757-2085-3. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 716-717. ...

Chemical pages without DrugBank identifier, Articles without KEGG source, Articles without InChI source, Drugs with no legal ... Rociverine is an antimuscarinic drug. Toson G, Schiantarelli P, Murmann W (1978). "Rociverine, a new antispasmodic agent with ...

Selection Versus Design in Chemical Engineering The ETH-2 human antibody phage library Sidhu SS, Lowman HB, Cunningham BC, ... Lawrence S (April 2007). "Billion dollar babies--biotech drugs as blockbusters". Nat. Biotechnol. 25 (4): 380-2. doi:10.1038/ ... Barbas CF, Bain JD, Hoekstra DM, Lerner RA (May 1992). "Semisynthetic combinatorial antibody libraries: a chemical solution to ... phage display is a useful tool in drug discovery. It is used for finding new ligands (enzyme inhibitors, receptor agonists and ...

PTGS1 (COX-1) and PTGS2 (COX-2) are bifunctional enzymes that carry out two consecutive chemical reactions in spatially ... Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by PTGS1 (COX-1) and PTGS2 (COX-2). NSAIDs ... Porter NA (1986). "Mechanisms for the autoxidation of polyunsaturated lipids". Accounts of Chemical Research. 19 (9): 262-8. ... drug-candidates that selectively inhibit PTGS2 (COX-2) were suspected to show fewer side-effects but proved to substantially ...

... and green laser pointers Cronex X-ray image intensifier phosphors and screens Building 400 Hyzaar combination drug to treat ... Chilton's unit operations for chemical engineering Solamet PV17x, PV18x, PV19x, and PV20x photovoltaic metallization pastes ...

HR sees chemical dependency and related behaviors as a response to a lack of a sense of self-efficacy, rather than the result ... After three years, there were major documented reductions in crime, drug dealing, teenage pregnancy, child abuse, child neglect ... County of Santa Clara Department of Alcohol & Drug Services Health Realization Services Division, 2007. Retrieved Oct. 19, 2007 ... drugs, or other compulsive behaviors in the attempt to quell their stressful feelings and regain some momentary sense of ...

Some chemical denture cleaners can come in cream and liquid format. Others come in powder, paste, or tablet format. Some ... "History of Block Drug Company, Inc. - FundingUniverse". www.fundinguniverse.com. Retrieved 2020-06-11. "Mid-Continental Dental ... In the 1930s, Alexander Block developed the Polident brand of denture cleaner at the Block Drug Company. Others have followed ... Other ingredients include such chemicals as: sodium bicarbonate - or baking soda, which alkalizes the water, cleaning the ...

Drugs and illegal aliens are routinely smuggled into this country, not only in small boats but also hidden among otherwise ... and chemical weapons" working U.S. ports of entry. Airport security mechanisms must be quick, efficient, and effective due to ... "National Southwest Border Counternarcotics Strategy" (PDF). Office of National Drug Control Policy. 2013. Archived (PDF) from ... "drugs and illegal aliens are routinely smuggled into this country, not only in small boats but also hidden among otherwise ...

Chemical pages without DrugBank identifier, Articles without KEGG source, Drugs missing an ATC code, Drugboxes which contain ... "Spectrum Data of the 3rd Governor-designated Drugs and the Analyses of Uncontrolled Drugs Purchased" (PDF). Tokyo Metropolitan ... "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on ... It has been reported to be sold as a designer drug, but little is known about its pharmacology or

Chemical pages without DrugBank identifier, Drugs with no legal status, Articles containing unverified chemical infoboxes, AMPA ... 1031-. ISBN 978-1-4557-3767-3. v t e (Articles with short description, Short description matches Wikidata, Drugs not assigned ... 514-. ISBN 978-3-540-68698-9. Olesen J, Ramadan N (21 August 2008). Innovative Drug Development for Headache Disorders. Oxford ... but ultimately neither drug was ever marketed. Irampanel Selurampanel Stolerman IP (31 July 2010). Encyclopedia of ...

Chemical pages without DrugBank identifier, Drugs with no legal status, Drugboxes which contain changes to verified fields, ... "Discontinued drugs in 2005: anti-infectives". Expert Opinion on Investigational Drugs. 16 (1): 1-10. doi:10.1517/13543784.16. ... Antiviral drugs, Pyrimidinediones, Organofluorides, Abandoned drugs, All stub articles, Antiinfective agent stubs). ... v t e (Articles with short description, Short description matches Wikidata, Drugs not assigned an ATC code, Articles with ...

Drug and Chemical Toxicology. 6 (1): 21-40. doi:10.3109/01480548309072460. PMID 6861661. Joss, R (1983). "A phase I trial of ... The bottom fragment of rudolphomycin is a cyclic (sugar) compound with a chemical formula C6H8NO3 and a proposed trivial name ... Bohemic acid is a mixture of chemical compounds which is obtained through fermentation by actinobacteria species in the genus ... Marcellomycin and mimimycin, and collinemycin and musettamycin are stereoisomers, that is they have the same chemical ...

395-. ISBN 978-1-4832-7299-3. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and ... Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, ... Chemical articles without CAS registry number, Articles without EBI source, Chemical pages without ChemSpiderID, Chemical pages ... The drug has also been assessed at steroid hormone-associated carrier proteins, and shows very low binding to sex hormone- ...

Council A, Kuenssberg V (1974-02-01). "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. BMJ ... Timiperone has a similar chemical structure with a thiourea group instead of a urea group. Pimozide & Bezitramide (& ... "NCATS Inxight Drugs - BENPERIDOL". Retrieved 13 March 2022. Li P, Snyder GL, Vanover KE (December 2016). "Dopamine Targeting ... Roth BL, Driscol J. "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill ...

Chemical pages without DrugBank identifier, Drugs with no legal status, Drugboxes which contain changes to verified fields, ... This drug was also shown to induce pain in patients with atypical facial pain. After taking the drug on empty stomach, it is ... This drug decreases the permeability and fragility of blood vessels, which reduces the number of migraine days and attenuates ... Wiedemann, Meike; de Lima, Vera M. Fernandes; Hanke, Wolfgang (1996-04-01). "Effects of antimigraine drugs on retinal spreading ...

Drug and Chemical Control. DIANE Publishing. pp. 250-. ISBN 978-1-4379-8272-5. https://dominica.gov.dm/images/documents/bills_ ... Cannabis in Dominica is a Class B drug to cultivate, sell or possess. This means that possession is punishable by 12 months and ... Drugs (Prevention of Misuse) Act, Chapter 40:07 (PDF), retrieved 2011-02-17 DIANE Publishing Company (1 August 1995). ... Drugs in Dominica, All stub articles, Cannabis stubs, Dominica stubs). ...

Articles containing unverified chemical infoboxes, Cannabinoids, Experimental drugs, Trifluoromethyl compounds). ... Articles with short description, Short description matches Wikidata, Drugs not assigned an ATC code, Articles without EBI ... source, Chemical pages without DrugBank identifier, Articles without KEGG source, ...

v t e (Drugs not assigned an ATC code, Chem-molar-mass both hardcoded and calculated, Articles without EBI source, Chemical ... pages without DrugBank identifier, Articles without KEGG source, Drugs with no legal status, Catechols, D1-receptor agonists, ...

The book goes on to state that the Pure Food and Drug Act of 1906 is not effective in arresting these trends, and real reform ... herbicides and other chemicals in food production. Preservatives are particularly criticized, and the increase in canned or ... "The Story Of The Laws Behind The Labels Part II: 1938--The Federal Food, Drug, and Cosmetic Act". Centre for Food Safety and ... 100,000,000 Guinea Pigs: Dangers in Everyday Foods, Drugs, and Cosmetics is a book written by Arthur Kallet and F.J. Schlink ...

FDA Issues Advisory on "Teas": Teas Made from Star Anise Were Associated With Illnesses Including Seizures, US Food and Drug ... JI-YOUNG KIM et al., Chemical composition, antioxidant, anti-elastase, and anti-inflammatory activities of Illicium anisatum ...

... an anticonvulsant drug used in the treatment of epilepsy This set index page lists chemical structure articles associated with ...

An accomplished apothecary with a large stock of chemicals, drugs, poisons, and a very small venomous snake. Poledra, wife to ... The use of drugs and poisons is common in politics. Sendars are a people of primarily Alorn and Arendish descent, located north ...

One such analog, known as Ixabepilone is a U.S. Food and Drug Administration approved chemotherapy agent for the treatment of ... Myxobacteria produce a number of biomedically and industrially useful chemicals, such as antibiotics, and export those ... physico-chemical and biological properties, and mechanism of action". J. Antibiot. 48 (1): 21-5. doi:10.7164/antibiotics.48.21 ... chemicals outside the cell. Myxobacteria are used to study the polysaccharide production in gram-negative bacteria like the ...

Chemical pages without DrugBank identifier, Drugs with no legal status, Antiparkinsonian agents, Drugs with unknown mechanisms ... Kornhuber J, Herr B, Thome J, Riederer P (1995). "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in ... Owen JC, Whitton PS (October 2006). "Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular ... Schaefer H, Hackmack G, Eistetter K, Krüger U, Menge HG, Klosa J (1984). "[Synthesis, physical-chemical properties and ...