Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Chemicals that are used to cause the disturbance, disease, or death of humans during WARFARE.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Databases devoted to knowledge about specific chemicals.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.
Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
The rate dynamics in chemical or physical systems.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
The use of chemical agents in TERRORISM. This includes the malevolent use of nerve agents, blood agents, blister agents, and choking agents (NOXAE).
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
The characteristic three-dimensional shape of a molecule.
Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
The relationship between the dose of an administered drug and the response of the organism to the drug.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Elements of limited time intervals, contributing to particular results or situations.
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
Separation of a mixture in successive stages, each stage removing from the mixture some proportion of one of the substances, for example by differential solubility in water-solvent mixtures. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The study of ENVIRONMENTAL POLLUTION and the toxic effects of ENVIRONMENTAL POLLUTANTS on the ECOSYSTEM. The term was coined by Truhaut in 1969.
A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.
The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.
The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The process of cleaving a chemical compound by the addition of a molecule of water.
Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.
The process of finding chemicals for potential therapeutic use.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Characteristics or attributes of the outer boundaries of objects, including molecules.
Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
Baselt, R. (2011). Disposition of Toxic Drugs and Chemicals in Man (9th ed.). Seal Beach, CA: Biomedical Publications. pp. 1644 ... A Primer on the UN Drug Control Conventions. Transnational Institute "Drug Schedules; Schedule 1". US Drug Enforcement Agency, ... Firn, Richard (2010). Nature's Chemicals. Oxford: Biology. Pate, David W. (1994). "Chemical ecology of Cannabis". Journal of ... such as in the United States where the National Institute on Drug Abuse and Drug Enforcement Agency regulated sources of ...
ISBN 0-87341-832-8. "Federal Food, Drug, and Cosmetic Act". US Food and Drug Administration. "Food Chemicals Codex". United ... "Food Chemicals Codex". "FD&C Act Chapter IV: Food". US Food and Drug Administration. Ayres, Chris (27 February 2010), Clean ... In Mexico, a man who worked for drug cartels admitted to having disposed of more than 300 bodies with it. A 3-10% solution of ... In the United States, food-grade lye must meet the requirements outlined in the Food Chemicals Codex (FCC),[page needed] as ...
Armaments L65 Chemicals • Rubber • Drugs • Biotechnology • Plastics L66 Food • Beverages • Cosmetics • Tobacco • Wine and ...
Specialty Chemicals 4. Organic Chemicals Synthesis 5. Drugs 6. Cosmetic Chemicals 7. Food Additives 8. Agricultural Chemicals 9 ... Military Purpose Chemicals 11. Electro Chemicals 12. Inorganic Chemicals 13. Industrial Chemicals And Additives 14. ... Photographic Chemicals 15. Industrial Cleaning And Protection Chemicals 16. R & D And Laboratory Chemicals 17. Corrosion ... Kimetsan is one of the largest chemical companies in Turkey today. In terms of product number, the company is the biggest ...
Chemicals; Rubber; Drugs; Biotechnology JEL: L66 - Food; Beverages; Cosmetics; Tobacco; Wine and Spirits JEL: L67 - Other ...
"The party is over" for illicit drug users, he announced, with the new policy aiming towards widespread arrest of drug users, in ... "Canada's Chemicals Management Plan". Health Canada. Archived from the original on January 11, 2013. Retrieved February 14, 2012 ... Clement stated that governments in Canada have been sending the wrong message about drug use, and he wanted to clear up the ... Clement also played a key role in launching the Chemical Management Plan, which the Conservative government claimed "made ...
Industrial Guide to Chemical and Drug Safety. Wiley-IEEE. pp. pp189-191. ISBN 0-471-23698-5. (Google Books) Topping, M. (2001 ... Industrial or Occupational Hygienists are often on the front line of anticipating and recognizing the hazards of chemical ... Occupational Exposure Limits (OELs) have been established for airborne workplace chemicals by multiple regulatory and ... "Occupational Exposure Limits for Chemicals". Occupational and Environmental Medicine. 58 (2): 138-144. doi:10.1136/oem.58.2.138 ...
"Dextromethorphan" (PDF). Drugs and Chemicals of Concern. Drug Enforcement Administration. August 2010. Archived from the ... A comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis. 6 (7-8): 614-32. doi:10.1002/ ... Giannini AJ (1997). Drugs of abuse (2nd ed.). Los Angeles: Practice Management Information Corp. ISBN 1570660530. [page needed ... 514" (PDF). An act to add Sections 11110 and 11111 to the Health and Safety Code, relating to nonprescription drugs. State of ...
It manufactured drugs under licence from "Beecham Pharmaceuticals" (today known as GlaxoSmithKline (GSK)). In 2004, it was ... In 2015, Dawa Limited acquired 100% shareholding in "KEL Chemicals", a manufacturer of superphosphate fertilizer and sulphuric ... Besides manufacturing and distributing human and veterinary drugs, Dawa Limited is part of a consortium, that is developing a ... Economy of Kenya Kariuki, James (24 September 2017). "Drugs firm to spend Sh3 billion on Nairobi plant expansion". Business ...
... or physico-chemical properties in QSPR models of chemicals (drugs/toxicants/environmental pollutants) with descriptors ... Drug discovery often involves the use of QSAR to identify chemical structures that could have good inhibitory effects on ... Patani GA, LaVoie EJ (Dec 1996). "Bioisosterism: A Rational Approach in Drug Design". Chemical Reviews. 96 (8): 3147-3176. doi: ... ISBN 0-8247-2397-X. Dossetter AG, Griffen EJ, Leach AG (2013). "Matched molecular pair analysis in drug discovery". Drug ...
Cayman Chemical. "4-Methoxybutyrfentanyl". New Synthetic Drugs Database. "ANALYTICAL REPORT - 4-MeO-BF" (PDF). European project ... is an opioid analgesic that is an analog of butyrfentanyl and has been sold online as a designer drug. Side effects of fentanyl ... International Journal of Drug Policy. 26 (7): 626-631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511. Anders Helander; ...
Chemical Reviews. 110 (6): 3315-36. doi:10.1021/cr8002888. PMID 20353181. Anti-rejection drugs Molecular and Cellular Biology ... FKBP (FKBP1A) does not normally form a dimer but will dimerize in the presence of FK1012, a derivative of the drug tacrolimus ( ... Tacrolimus has been found to reduce episodes of organ rejection over a related treatment, the drug ciclosporin, which binds ...
Drug Enforcement Administration. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September ... ISBN 978-92-9168-925-5. "MDMB-CHMICA". Cayman Chemical. Retrieved 29 June 2015. "MDMB-CHMICA". Southern Association of Forensic ... European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). 31 August 2016. "COUNCIL IMPLEMENTING DECISION (EU) 2017/369 ... European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). July 2016.
Chemical Peeling. American Society for Dermatological Surgery. Lasik Laser Eye Surgery. USA Food an Drugs Administration info. ... can be carried out by chemicals (chemoablation), by lasers (laser ablation), by freezing (cryoablation), or by electricity ( ...
Conti P, Tamborini L, Pinto A, Blondel A, Minoprio P, Mozzarelli A, De Micheli C (September 2011). "Drug Discovery Targeting ... In enzymology, a proline racemase (EC is an enzyme that catalyzes the chemical reaction L-proline ⇌ {\displaystyle \ ... Amino Acid Racemases". Chemical Reviews. 111 (11): 6919-46. doi:10.1021/cr2000702. PMID 21913633. Molecular and Cellular ...
Baselt RC (2014). Disposition of toxic drugs and chemicals in man. Seal Beach, Ca.: Biomedical Publications. p. 1751. ISBN 978- ... "Drugs of Abuse Emerging Trends". National Institute on Drug Abuse. 6 April 2015. Marinetti, L. J.; Antonides, H. M. (2013). " ... Bath salts' death: lethal drug was a top seller". The Sydney Morning Herald. "Flakka, synthetic drug behind increasingly ... European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). September 2015. Julie A. Marusich; Kateland R. Antonazzo; ...
Cayman Chemical. Retrieved 10 August 2015. "UNODC EWA: Fifteen novel synthetic cannabinoids reported to UNODC EWA since the ... is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family that has been sold online as a designer drug ... beginning of the year". United Nations Office on Drugs and Crime (UNODC). Retrieved 10 August 2015. "EWS_EU / AT: checkit; neue ...
"Passion Flower". Retrieved 14 January 2015. Archived 2007-09-27 at the Wayback Machine. Ma, ... "Chemical Information". Archived from the original on 2004-11-21. Retrieved 2008-04-11. "Silbrige Ayahuasca- ... "Profiles of Psychedelic Drugs". Retrieved 2008-04-19. "Lycaeum > Leda > Acacia acuminata". leda.lycaeum. ... or a dissociative drug. Cannabis plants tend to vary, with different strains producing dynamic balances of cannabinoids (THC, ...
... off-the-shelf chemical probes of receptor interactions, signaling, and fate". Chemical Biology. 12 (6): 703-715. doi:10.1016/j. ... stock surged with the clinical data ozanimod displayed as a S1P immunomodulating drug. In August 2015, Receptos was acquired by ... Ozanimod (RPC-1063) is an investigational immunomodulatory drug currently in phase III clinical trials for the therapy of ... Expert Opinion on Drug Metabolism & Toxicology. 5255 (8): 879. doi:10.1080/17425255.2016.1196188. Sandborn, W. (2016). " ...
An application is the development of chemical sensors. Finding a drug which either blocks a receptor, an antagonist which forms ... A chemical system is said to be in equilibrium when the quantities of the chemical entities involved do not and cannot change ... ISBN 0-471-98831-6. Cattrall, R.W. (1997). Chemical sensors. Oxford University Press. ISBN 0-19-850090-4. "Drug discovery today ... In this sense a system in chemical equilibrium is in a stable state. The system at chemical equilibrium will be at a constant ...
As a result, the function of these drugs is to serve as enzyme poisons rather than inhibitors. This can be applied to treat ... DNA-protein crosslinking can be caused by a variety of chemical and physical agents, including transition metals, ionizing ... "Nitrogen Mustard - Chemotherapy Drugs - Chemocare". Retrieved 2017-10-09. Jamieson, E. R.; Lippard, S. J. (1999- ... Because the toxicity of these drugs depends on TOP1 trapping, cellular sensitivity to these compounds depends directly on TOP1 ...
The elimination half-life is how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when ... Chemical and computer assisted development of an inclusive pharmacophore for the benzodiazepine receptor. Chapter 7, Biological ... Click on drug name to see a more comprehensive list. ** Flumazenil is an imidazobenzodiazepine derivative, and in layman's ... Drug Res. 1985 (14): 165-322. CS1 maint: Multiple names: authors list (link) Winkler DA, Burden FR, Watkins AJR. Atomistic ...
Cayman Chemical. Retrieved 6 July 2015. "5F-AKB48" (PDF). Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG). ... Drug Enforcement Administration. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September ... 5F-APINACA (also known as 5F-AKB48) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. ... 5F-APINACA is an Anlage II controlled drug in Germany since July 2013. As of October 2015 5F-APINACA
"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. ... 4-Methylbuphedrone 4-Methylethcathinone Buphedrone Ethcathinone Etilamfetamine "N-Ethylbuphedrone". Cayman Chemical. " ... N-Ethylbuphedrone (also known as NEB) is a stimulant of the cathinone class that has been sold as a designer drug
"Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes". Science. 346 ... Drug Discovery. 13 (5): 337-56. doi:10.1038/nrd4286. PMID 24751816. Baud MG, Lin-Shiao E, Cardote T, Tallant C, Pschibul A, ... Drug Discovery. 10 (10): 732-3. doi:10.1038/nrd3569. PMID 21959283. Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, ... BET inhibitors are a class of drugs with anti-cancer, immunosuppressive, and other effects in clinical trials in the United ...
In 2016, the organization produced drugs at two government-owned factories. GPO makes and sells four categories of products: ... medicines; antiretrovirals; chemicals/test kits/natural products; and preventive medicines. Besides Thailand, it markets its ...
3 Drug interactions. *4 Chemical properties. *5 Biosynthesis. *6 Absorption and metabolism *6.1 Absorption ... Nanoparticles have been explored as a delivery system for various drugs, such as improving the oral bioavailability of drugs ... where Q refers to the quinone chemical group and 10 refers to the number of isoprenyl chemical subunits in its tail. ... Chemical properties[edit]. The oxidized structure of CoQ10 is shown on the top-right. The various kinds of Coenzyme Q may be ...
Chemicals and drugs[edit]. Some chemicals and drugs selectively destroy pancreatic cells. Pyrinuron (Vacor), a rodenticide ... Immunosuppressive drugs[edit]. Cyclosporine A, an immunosuppressive agent, has apparently halted destruction of beta cells (on ... One reason for this is that introducing a new kidney requires taking immunosuppressive drugs such as cyclosporine, which allows ... "Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review". Environmental Health ...
A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft. A ... Research chemicals[edit]. *Amiflamine (FLA-336). *Viqualine (PK-5078). *2-Methyl-3,4-methylenedioxyamphetamine (2-Methyl-MDA) ... The designer drug 4-methylaminorex, which is an SNDRA and 5-HT2B agonist, has been reported to cause this effect as well. ... Amphetamines like MDMA, MDEA, MDA, and MBDB, among other relatives (see MDxx), are recreational drugs termed entactogens. They ...
2.1 Physico-chemical properties. *2.2 In vitro test systems. *2.3 During drug development ... Physico-chemical properties[edit]. In vitro test systems[edit]. 3T3 Neutral Red Phototoxicity Test - An in vitro toxicological ... During drug development[edit]. Several health authorities have issued related guidance documents, which need to be considered ... The involved chemical may enter into the skin by topical administration or it may reach the skin via systemic circulation ...
... of title 21 bearing or containing a new animal drug. The term "pesticide" does not include liquid chemical sterilant products ( ... Adjuvants are chemicals added to enhance the performance or efficacy and/or alter the physical properties of the pesticidal ... Under Section 408 of the Federal Food, Drug, and Cosmetic Act (FFDCA), the EPA can also regulate the amount of pesticide ... any nitrogen stabilizer, except that the term "pesticide" shall not include any article that is a "new animal drug" within the ...
"CFR TITLE 21: DRUGS FOR HUMAN USE: PART 341 -- COLD, COUGH, ALLERGY, BRONCHODILATOR, AND ANTIASTHMATIC DRUG PRODUCTS FOR OVER- ... Chemical and physical data. Formula. C10H15N. Molar mass. 149.23 g·mol−1. ... "United States Food and Drug Administration. April 2015. Archived from the original on 18 September 2015. Retrieved 7 March 2016 ... Levomethamphetamine is the active metabolite of the antiparkinson's drug selegiline.[9] Selegiline, a selective monoamine ...
... : Dangers in Everyday Foods, Drugs, and Cosmetics is a book written by Arthur Kallet and F.J. Schlink ... herbicides and other chemicals in food production. Preservatives are particularly criticized, and the increase in canned or ... Jackson, J. "The Ergot Controversy: Prologue to the 1938 Food, Drug, and Cosmetic Act" J Hist Med Allied Sci 1968; XXIII: 248- ... Many people were shocked at the extent of food contamination and drug side-effects, and 100,000,000 Guinea Pigs, along with ...
Izzedine H, Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G (November 2005). "Drug-induced diabetes mellitus". Expert ... "Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease?". Journal of Internal ... Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus". Drugs. 65 (3): 385- ... Opinion on Drug Safety. 4 (6): 1097-109. doi:10.1517/14740338.4.6.1097. PMID 16255667.. ...
Chemical pages without DrugBank identifier. *Drugs with no legal status. *All stub articles ... This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.. *v ... Martndale: The Complete Drug Reference, 35th Ed. *^ a b Heinz Reichmann (October 2006). "Budipine in Parkinson's tremor". ... Kornhuber J., Herr B., Thome J., Riederer P. (1995). "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in ...
"Drug Discov Today 15 (23-24): 1052-7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. edit ... manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi: ... "PubChem as a public resource for drug discovery.". ...
After 38 weeks, 6% of the people in the three-drug group died while 11% of the people died in the two-drug group. There were ... Chemical and physical data. Formula. C36H47N5O4. ... Viral resistance to the drug leads to the drug becoming useless ... It is recommended that users drink at least 1.5 liters a day when intaking the drug. Drug users must significantly increase ... The Food and Drug Administration (FDA) approved indinavir on March, 1996, making it the eighth antiretroviral drug approved. It ...
De Smet, Peter A.G.M. (December 1997). "The Role of Plant-Derived Drugs and Herbal Medicines in Healthcare". Drugs. 54 (6): 801 ... "Biology-based" as coined by NCCIH may refer to chemicals from a nonbiological source, such as use of the poison lead in ... 2006). "Drug-related hepatotoxicity". New England Journal of Medicine. 354 (7): 731-39. doi:10.1056/NEJMra052270. PMID 16481640 ... The U.S. Food and Drug Administration (FDA), has issued online warnings for consumers about medication health fraud.[157] This ...
Gurib-Fakim, A.. Medicinal plants: traditions of yesterday and drugs of tomorrow.. doi:10.1016/j.mam.2005.07.008. ... Govinden-Soulange, J.; Magan, N.; Gurib-Fakim, A.; Gauvin, A.; Smadja, J.; Kodja, H.. «Chemical composition and in vitro ... Gurib-Fakim, A.; Bourrel, C.; H., Kodja; Govinden, J.. «Chemical Composition of the Essential Oils of Psiadia lithospermifolia ...
IPA also lets researchers search for information on genes, proteins, chemicals, drugs, and reagents. Resulting information can ... All QIAGEN Silicon Valley use the Ingenuity Knowledge Base, which contains biological and chemical interactions and functional ... Food and Drug Administration to use IPA in review of Pharmacogenomics Submissions" (Press release). Ingenuity Systems. June 21 ... US Food and Drug Administration adopts IPA to review pharmacogenomics submissions 2006 - Ingenuity enters into partnerships ...
R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. ...
Koiuszko, S; Bialucha, A; Gospodarek, E (2007). "[The drug susceptibility of penicillin-resistant Streptococcus pneumoniae]". ... "Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by ... or drug-resistant Strepotococcus pneumomoniae (DRSP). Until the year 2000 out of 60,000 yearly cases 40% and out of the 30,000 ...
Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John ... Accounts of Chemical Research. 48 (3): 653-662. doi:10.1021/ar500400w.. ... Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These ... They are a class of cell cycle-specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting ...
... drug occupancy at a purported site of action can be inferred indirectly by competition studies between unlabeled drug and ... Dilworth, Jonathan R.; Pascu, Sofia I. (2018). "The chemistry of PET imaging with zirconium-89". Chemical Society Reviews. 47 ( ... Pharmacokinetics: In pre-clinical trials, it is possible to radiolabel a new drug and inject it into animals. Such scans are ... The uptake of the drug, the tissues in which it concentrates, and its eventual elimination, can be monitored far more quickly ...
Drug sensitization occurs in drug addiction, and is defined as an increased effect of drug following repeated doses (the ... Electrical or chemical stimulation of the rat hippocampus causes strengthening of synaptic signals, a process known as long- ... addictive drug - a drug that is both rewarding and reinforcing. *dependence - an adaptive state associated with a withdrawal ... drug withdrawal - symptoms that occur upon cessation of repeated drug use. *physical dependence - dependence that involves ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... Viral replication triggers high levels of inflammatory chemical signals and leads to a septic state.[38] ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ... "U.S. Food and Drug Administration (FDA) (Press release). 20 December 2019. Retrieved 22 December 2019.. ...
Another synthetic drug specific to the adenosine A2A receptor subtype is CGS-21680 that has been shown to cause apneas in 14- ... Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at ... and chemical signals, such as adenosine, GABA, and glycine. The pre-Bötzinger complex produces two types of breathing rhythms ...
regulation of response to drug. • central nervous system development. • chloride transport. • ion transmembrane transport. • ... chemical synaptic transmission. • regulation of membrane potential. • nervous system process. • synaptic transmission, ...
"Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... or more are considered to be deep chemical peels.[32] Medium-strength and deep-strength chemical peels are more effective for ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs. 20 ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs ( ...
Drugs with non-standard legal status. *Chemicals that do not have a ChemSpider ID assigned ... Rituximab Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ... In 2014 Genentech reclassified rituxan as a specialty drug, a class of drugs that are only available through specialty ... "International Drug Price Indicator Guide. Retrieved 28 November 2015.. *^ British national formulary : BNF 69 (69 ed.). British ...
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.". Drug Discov Today. 15 (23-24): ... Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State ... of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug ...
JEL: L65 - Chemicals; Rubber; Drugs; Biotechnology. JEL: L66 - Food; Beverages; Cosmetics; Tobacco. JEL: L67 - Other Consumer ...
Drugs not assigned an ATC code. *ECHA InfoCard ID from Wikidata. *Chemical pages without DrugBank identifier ... Theanine is a chemical that you find in tea and in some mushrooms. Theanine is an amino acid. The chemical theanine can change ... This is a good chemical that fights aging. Theanine helps the immune system. This protects your body against diseases. ...
... by drugs known as neurokinin type 1 antagonists (also termed: SP antagonists, or tachykinin antagonists.) One such drug is ... "Blood chemicals link' to eczema". Health. BBC NEWS. 2007-08-26. Retrieved 2008-11-01.. ... Muñoz M, Rosso M, Coveñas R (Jun 2011). "The NK-1 receptor: a new target in cancer therapy". Current Drug Targets. 12 (6): 909- ... SP initiates expression of almost all known immunological chemical messengers (cytokines).[19][20][21] Also, most of the ...
"The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals (English)"; date o publication: 1996; page: 1613. ...
... Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ... Chemical and physical data. Formula. C6416H9874N1688O1987S44. ... Patents on the drug in expired in Europe in February 2013 and ... In 2014 Genentech reclassified rituxan as a specialty drug, a class of drugs that are only available through specialty ... "International Drug Price Indicator Guide. Retrieved 28 November 2015.. *^ British national formulary : BNF 69 (69 ed.). British ...
Aminorex a drug bearing an oxazoline ring. References[edit]. *^ a b Wenker, H. (1938). "Syntheses from Ethanolamine. V. ... Controlled reduction of oxazolium salts". Journal of the American Chemical Society. 110 (10): 3238-3246. doi:10.1021/ ... "Advanced Drug Delivery Reviews. 59 (15): 1504-1520. doi:10.1016/j.addr.2007.08.018. PMID 17904246.. ... Oxazoline is a five-membered heterocyclic chemical compound containing one atom each of oxygen and nitrogen. It was likely ...
"Drug Discov Today 15 (23-24): 1052-7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. edit ... manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi: ... 2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ... "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488-1493. PMID ...
An alcoholic drink (or alcoholic beverage) is a drink that contains the recreational drug ethanol, a type of alcohol produced ... According to a study published in the Proceedings of the National Academy of Sciences, chemical analysis of the residue ... Alcohol is one of the most widely used recreational drugs in the world, with about 33% of people being current drinkers.[4] As ... "Processing and chemical constituents of Pu-erh tea: A review." Food Research International 53.2 (2013): 608-618. ...
"Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings". RxList. Archived from ... Its chemical nature and physiologic activity". J. Am. Med. Assoc. 64 (25): 2042-2043. doi:10.1001/jama.1915.02570510018005.. ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon Pocket ... "Levothyroxine (Lexi-Drugs)". LexiComp. Archived from the original on 29 September 2014. Retrieved 20 April 2014.. ...
Adriano Andricopulo, Brazilian Chemical Society, Brazil. Emili Besalu, University of Girona, Spain. Ramon Carbo-Dorca, ... "Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment" (IGI Global, 2015). ... In presenting key research in the field of chemical research, IJQSPR aims to advance the current literature available across ... chemical engineering, pharmaceutical and medicinal chemistry, pharmacokinetics, toxicology (including ecotoxicology), and ...
Drugs and Medicine. Pharmaceutical products, biopharmaceuticals, dialysis. How many years I have to study? ... In a simpler way, Chemical engineers transform raw matter or chemicals into a more valuable and useful products. ... Currently, employment opportunities for Chemical Engineers in Puerto Rico are in: Pharmaceutical Industry, Chemical Products, ... and control of chemical, physical and biological processes, including a risks assessment of them. Chemical engineers discover, ...
Chemicals and Drugs Indexing Chemicals. MeSH contains thousands of chemicals, so it is likely that the specific chemical in a ... Simple Chemicals. In IMS, the indexer simply starts to type the name of the chemical, and then picks it from the automatic ... Complex Chemicals. For more complex chemical names, especially those containing combinations of letters, numbers, and ... The indexer can also go to the MeSH Browser, type the name of the chemical, and search for the exact term. For example, the ...
The chemicals can be specified (clarified) by adding an index prefix ,index_label=. , ,index2_label=. . See also Infobox drug ... This category lists articles that have a second identifier in {{Infobox drug}}, introducing a second chemical substance. For ... Pages in category "Multiple chemicals in Infobox drug". The following 200 pages are in this category, out of approximately 384 ... Retrieved from "" ...
DEA is extending for another six months its emergency ban on five chemicals used to make synthetic drugs such as Spice, it said ... The Drug Enforcement Administration is extending its ban for six months. *The one-year ban on the chemicals was set to expire ... The Drug Enforcement Administration is extending for another six months its emergency ban on five chemicals used to make ... The DEA extended another six months its ban on five chemicals used to make synthetic drugs such as Spice. ...
Ditch the itch: Researchers find new drug to fight hives. A new drug works by targeting an immune system antibody called ... 5-MeO-DMT is a psychoactive tryptamine which was first identified in the mid 20th Century as a chemical in a South American ... Phencyclidine (PCP) is a chemical in the dissociative anaesthetic class. Mescaline Mescaline is a psychoactive phenethylamine ... chemical, best known for being the primary psychoactive component in peyote and San Pedro cacti. ...
... Mohamed M. Abdel-Daim,1 Salah M. Aly,2 Khaled Abo-el- ...
Now, research hints that chemicals lurking in clothing and furniture may play a role i ... Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ... Drug Safety Communication: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) - Avoid Use of NSAIDs in Pregnancy at 20 Weeks or ...
Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of ... Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of ... Alcohol Interactions with Drugs and Chemicals will be a valuable reference tool for environmental scientists, toxicologists, ... Revival: Alcohol Interactions with Drugs and Chemicals (1991) By Edward J. Calabrese. ...
Researchers at the University of Warwick found that when the chemical, Sodium Formate, is used in combination with a metal- ... A cancer drug could be made 50 times more effective by a chemical found in stinging nettles and ants, new research finds. ... Stinging nettle chemical improves cancer drug A cancer drug could be made 50 times more effective by a chemical found in ... Stinging nettle chemical improves cancer drug. University of Warwick. Journal. Nature Communications. Funder. European Research ...
The Transfer of Drugs and Other Chemicals Into Human Milk. Committee on Drugs ... The Transfer of Drugs and Other Chemicals Into Human Milk Message Subject (Your Name) has sent you a message from American ... 2) Use the safest drug, for example, acetaminophen rather than aspirin for analgesia. (3) If there is a possibility that a drug ... The following question and options should be considered when prescribing drug therapy to lactating women. (1) Is the drug ...
Chemists Prepare Molecules that Accelerate Chemical Reactions for Manufacturing Drugs. by Sam Savage ... In their paper, the UCR chemists discuss a set of chemical reactions involving the use of catalysts other than those that are ... "For more than a century, most catalysts were prepared using chemical compounds called phosphines," said Guy Bertrand, the lead ... All of this can dramatically reduce the cost of manufacturing drugs, given that pharmaceutical companies are increasingly using ...
A chemical tailor-made suit for Alzheimers drugs. University of Göttingen. Journal. Biochemistry. Keywords. *ALZHEIMERS ... A chemical tailor-made suit for Alzheimers drugs Research team from Göttingen and Halle develops new inhibitors for enzymes ... Drug Design and Target Validation Department Weinbergweg 22, 06120 Halle/Saale, Germany Tel: +49 (0)345 131428-15 Email: hans- ... "We are confident that our results will lead to the development of a new, highly selective generation of Alzheimers drugs," ...
The banning of certain types of a common class of chemicals known as phthalates has reduced Americans exposure to the chemicals ... Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ... Clearly we need better safety testing for chemicals before they come to market, so we can be sure that replacement chemicals ...
Click chemistry for drug development and diverse chemical-biology applications.. Thirumurugan P1, Matosiuk D, Jozwiak K. ...
Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive ... and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that ... Drug-DNA Interactions: Structures and Spectra. Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan ... Gary D. Strahan uses physico-chemical techniques to understand biological systems relevant to pharmaceutical discovery and ...
106,079 to investigate naturally occurring chemicals found in sea sponges in an effort to find out more about anti-cancer drugs ... Young UK scientists find a way of tweaking chemical structures of molecules from deepsea sponges to make anti-cancer drugs. A ... 106,079 to investigate naturally occurring chemicals found in sea sponges in an effort to find out more about anti-cancer drugs ... The discovery also allows the researchers to make variations of the psammaplin A chemical and to use these variants to further ...
The announcement follows the massive recall of blood pressure and heartburn drugs that took place earlier this year due to ... The FDA announced its currently testing the widely used diabetes drug metformin for NDMA, a cancer-causing contaminant. ... Certain metformin drugs in other countries were reported to contain low levels of the chemical, but the amount is within the ... The Food and Drug Administration (FDA) announced its currently testing the widely used diabetes drug metformin for a cancer- ...
... issued the Work Plan for Reforming Chemical Drugs Registration Classification System (the… ... MARCH 11, 2016 SIDLEY UPDATE China Reforms Its Chemical Drug Classification System On March 4, 2016, China Food and Drug ... Under the New Classification, chemical drugs are classified into five categories: 1. Category I: Innovative new drugs not ... China Reforms Its Chemical Drug Classification System Sidley Austin LLP To view this article you need a PDF viewer such as ...
Many research chemicals are structurally similar to scheduled chemicals, and could be considered to be analogues. Some of ... is a psychoactive drug that is implicitly sold for use in scientific and medical research. ... Introduction to Research Chemicals. Research chemical (RC) is a term applied to a broad variety of psychoactive drugs that ... Forms of Research Chemicals. As suggested above this class of drugs is extremely broad, covering a diverse chemical space. The ...
The US state of Georgia executed another inmate late Thursday night amid reports it is seeking to use up supplies of the drug ... Chemical state: Georgia rushes to use lethal-injection drug before expiration 22 Feb, 2013 01:05 ... "Executions are absolutely not the time to charge forward in haste just to ensure that drugs dont expire," Kathryn Hamoudah, a ... First with the illegal importation and distribution by the doctor who performs executions and then the seizure of the drugs ...
Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug-Target Interactions.. Horn M1, Metge F1, Denzel MS ... Here we describe a general protocol for a chemical mutagenesis-based forward genetic screen applicable for drug-target ... Amino acid resolution; Chemogenomics; Drug-target interaction site mapping; Genetic screen; Unbiased chemical mutagenesis ... have already been very successful in identifying drug targets and pathways related to the drugs mode of action. By inducing ...
Drs Francesca Paradisi and Martina Contente of the University of Nottingham produce chemicals more efficiently through a looped ... of Nottingham have created a self-sustaining circuit of reactions which is a greener and more efficient method of chemical ... University of NottinghamNewsPress releases2018JuneSelf-sustaining loop of chemical reactions could revolutionise drug ... Traditional chemical strategies may require up to two weeks to produce a yield of 5-13 per cent for the most challenging ...
It also includes chemicals that are essential in illicit drug manufacturing, such as the solvent acetone and acetic anhydride, ... Drug Enforcement Administration on ways to control domestic and international trade in chemicals used to manufacture illicit ... The ad hoc group of chemical manufacturers and distributors expects to reach an agreement soon with the drug-enforcement agency ... or chemical intermediates.. While the chemical industry is in support of the goal of the DEA . . . we want to find a method ...
The basic premise is that two proteins sharing a common bound chemical will likely share others. We use protein and chemical ... We show for a benchmark that known protein-chemical structures are reconstructed with good accuracy and sometimes via very ... different proteins and chemicals. We make thousands of confident predictions, including structures for known protein-drug ... We take a novel approach using protein-chemical interactions derived from 3D structures. ...
Drug, Chemical Residues Get More FSIS Attention By Dan Flynn , March 30, 2011. The Food Safety and Inspection Service (FSIS) ... FSIS inspectors use the Fast Antimicrobial Drug and Kidney Inhibition Swab to detect chemical residues in animal and swine. ... has decided to tweak procedures it follows in monitoring for the chemical residues left by animal drugs. It is going to take ... through the in-plant screening tests used to detect chemical residue from animal drugs. ...
Remove prescription drugs from original containers.. *Put the drugs into a disposable container with a lid, such as an empty ... Swedish researchers tested an anti-anxiety drug called oxazepam (found in water sources) on perch in the lab. The drug caused ... and an unknown number of industrial chemicals containing traces of EE2. Chemicals in pharmaceuticals such as anti-seizure ... The Effects of Drugs on Fish. Nobody asks fish or animals if they are depressed, but studies have found that they are ingesting ...
Drug-Rehab.ORG is free directory and referal service. Our mission is to provide meaningful information to our visitors, and to ... Disclaimer: is a directory listing service and does not engage in providing medical advice. Call 911 if you ... will place you in contact with a trained advisor from one of our sponsoring treatment providers. ...
... have developed a novel approach for identifying how chemicals in the environment - called... ... With structure-based drug design, chemists can use this new approach to visualize how to modify drug-candidate chemicals to ... "Scripps Florida scientists develop drug discovery approach to predict health impact of endocrine-disrupting chemicals." Medical ... Scripps Florida scientists develop drug discovery approach to predict health impact of endocrine-disrupting chemicals. ...
... the Global Diarrhea Drug Market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022 ... 1 Diarrhea Drug Market Overview. 1.1 Product Overview and Scope of Diarrhea Drug. 1.2 Diarrhea Drug Segment by Type (Product ... 2.5 Diarrhea Drug Market Competitive Situation and Trends. 2.5.1 Diarrhea Drug Market Concentration Rate. 2.5.2 Diarrhea Drug ... 5.2 Global Diarrhea Drug Revenue and Market Share by Type (2012-2017). 5.3 Global Diarrhea Drug Price by Type (2012-2017). 5.4 ...
... Lei Chen,1 Tao Huang,2 ... classification of drugs by integrating chemical-chemical interactions and similarities," PLoS ONE, vol. 7, no. 4, Article ID ... J. Scheiber, J. L. Jenkins, S. C. K. Sukuru et al., "Mapping adverse drug reactions in chemical space," Journal of Medicinal ... L. Xie, J. Li, L. Xie, and P. E. Bourne, "Drug discovery using chemical systems biology: identification of the protein-ligand ...
  • Look around you… each product that we use is a product of chemical compounds or an intermediate. (
  • He then moved to the Chemical and Biomolecular Engineering department at the University of Illinois at Urbana-Champaign, where he obtained his Ph.D. under the tutelage of Prof. Huimin Zhao developing cooperative one-pot chemoenzymatic reactions. (
  • The meeting captivated a vicinity of utilitarian discussions on novel subjects like Advances in Catalysis, Chemical Reaction Engineering, Environmental Catalysis and Nano Catalysis, Biocatalysis, Biotransformation and Organocatalysis, Photochemistry, Photobiology and Electrochemistry, to mention a few. (
  • Chemical Engineering combines three basic physical sciences: chemistry, physics and biology, alongside mathematics, and applies them to the design, analysis, and control of chemical, physical and biological processes, including a risks assessment of them. (
  • Which products surround you as a result of Chemical Engineering work? (
  • Pursuing a Chemical Engineering Bachelor at UPRM takes five years. (
  • Yet, Chemical Engineering students differ, since their curriculum is also oriented towards a strong preparation in chemistry fundamentals during the first years. (
  • If you have these qualities, you should consider Chemical Engineering as your profession of choice. (
  • The Department of Chemical Engineering proudly welcomes three new faculty members. (
  • He emigrated to the U.S. where he received his B.S. degree in Chemical Engineering from North Carolina State University. (
  • Mérida is a recent graduate of the University of Puerto Rico, Mayagüez Chemical Engineering Ph.D. program. (
  • His current teaching interests include Unit Operations, Bioprocess Engineering, and nanoparticle-based Drug Delivery. (
  • The BS in Chemical Engineering is accredited by the Engineering Accreditation Commission of ABET, (
  • Chemical engineering deals with the design and development of procedures to create products - products like food and fuel. (
  • With a degree in chemical engineering from South Dakota Mines, you can work in jobs that increase crop yields to combat world hunger, create new materials, reduce pollution, and meet energy demands. (
  • Chemical engineers are in high demand, especially chemical engineering graduates from South Dakota Mines. (
  • The average starting salary for a Mines chemical engineering graduate is $69,848. (
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  • As a chemical engineering major at South Dakota Mines, you don't have to wait to participate in research. (
  • There is not a fitted mold of qualities to become a Chemical Engineer, however, the above mentioned characteristics could indicate a potential successful candidate in this career. (
  • They do this by applying the principles of chemistry, biology, physics, and math to solve the problems that occur during the production of chemicals, fuel, drugs, food, and a myriad of other products. (
  • There are physical phenomenon fundamentals that are important to Chemical Engineers as they develop and implement them in chemical processes. (
  • Chemical engineers discover, develop and implement creative solutions to current world problems in order to benefit humankind. (
  • In a simpler way, Chemical engineers transform raw matter or chemicals into a more valuable and useful products. (
  • Chemical engineers lead to larger scales what the chemists elaborate on a laboratory in much smaller scales. (
  • Once a potential product is identified, chemical engineers verify if it can be produced on larger scales, which is the efficiency and at what pressure and temperature conditions can be done, etc. (
  • Who are good Chemical Engineers? (
  • Design engineers formulate the equipment and plant specifications in order to implement the desired chemical process, it also evaluates its construction and startup. (
  • Chemical engineers take raw materials and create every day, usable products. (
  • Chemical engineers (and biological engineers) are instrumental in creating pharmaceuticals and lifesaving devices such as the artificial kidney. (
  • Whereas historically drugs such as heroin and cocaine have been considered the "dangerous" drugs, in recent years, prescription drug abuse has far surpassed "illegal" drugs as agents of lethal drug toxicity. (
  • Alcohol Interactions with Drugs and Chemicals is a concise volume that identifies, documents, and assesses the capacity of alcohol to alter the toxicity of chemical pollutants and drugs in animal models and humans. (
  • Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. (
  • We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. (
  • We describe three case studies of complementary multi-scale computational modeling approaches to understand perturbation of toxicity pathways in the human liver as a result of exposure to environmental contaminants and specific drugs. (
  • Central to this vision is the idea of "toxicity pathways" - innate cellular signaling pathways that are perturbed by chemicals and pharmaceuticals, and the determination of chemical concentration ranges where those perturbations are likely to be excessive, thereby leading to adverse health effects if present for a prolonged duration in an organism. (
  • In 2009, the U.S. Environmental Protection Agency published its Strategic Plan for Evaluating the Toxicity of Chemicals ( U.S.EPA, 2009 ), which also envisions dynamic mathematical modeling as a key component of risk assessment linking toxicity pathways to dose-response. (
  • Derivatives of lumiracoxib were synthesised to understand the contribution of different chemical groups to toxicity. (
  • Changes to compound stability (via formation of oxidised products, -OH), chemical reactivity, and metabolite formation were observed and they allude to the mechanism for causing toxicity. (
  • A research team led by Prof HO Han Kiat from the Department of Pharmacy, NUS has discovered the mechanisms involved when minor chemical modifications such as a single substitution of a small halogen or alkyl group (functional groups in chemical structures) of pharmaceutical drugs alters the toxicity profile of the drugs. (
  • By understanding the specific mechanisms contributing to the toxicity, pharmaceutical scientists can modify the chemical structure so as to develop drugs which are more effective and safe. (
  • As part of the research, the team used a pair of anti-inflammatory drugs, diclofenac and lumiracoxib, that differ minimally in terms of structure, but exhibit profound differences in terms of toxicity. (
  • Many other compounds with small chemical changes were also synthesised and evaluated for their potential to cause toxicity and how they may be metabolised differently in liver cells. (
  • Structure-toxicity relationship and structure-activity relationship study of 2-phenylaminophenylacetic acid derived compounds, Food and Chemical Toxicology (2014). (
  • The new tests use cell cultures rather than animals to establish the toxicity of cancer drugs and identify contaminated drugs. (
  • David Paul Lambert was sentenced to eight years and two months in prison at the start of 2019 on numerous offences including possession of a range of dangerous drugs. (
  • Global Antibacterial Drugs Market 2015-2019 is a new research report added by under the Pharmaceutical category. (
  • The analysts forecast global antibacterial drugs market to grow at a CAGR of 1.06% over the period 2014-2019. (
  • This report covers present scenario and growth prospects of the global antibacterial drugs market for 2015-2019. (
  • The report, Global Antibacterial Drugs Market 2015-2019 , has been prepared based on an in-depth market analysis with inputs from industry experts. (
  • Several medical examiners' offices that routinely test for alcohol and drugs of abuse report finding some substance on toxicologic analysis in at least 50% of their cases. (
  • Alcohol Interactions with Drugs and Chemicals will be a valuable reference tool for environmental scientists, toxicologists, epidemiologists, and alcohol researchers studying the interactions of alcohol with drugs and chemical pollutants. (
  • Alcohol and other drug abuse is estimated to cost the nation over $160 billion per year in lost productivity, health care costs, and crime. (
  • There are constant reminders in the news media of the ever-present effects of alcohol and other drug abuse. (
  • Health care professionals witness the effects of alcohol and other drug use on the health of the population every day. (
  • Outpatient alcohol and drug treatment serving Crow Wing County and surrounding areas. (
  • Alcohol is a Drug? (
  • As the most widely used and accepted drug, alcohol has wrecked havoc on millions of families. (
  • Millions of people affected by drugs and alcohol continue to endure the damages of addiction because they don't think they can afford to get help. (
  • SB-1247 Vessels: operation under the influence of alcohol or drugs: chemical testing. (
  • They have a four times higher rate of drug, drug and alcohol abuse. (
  • Researchers at the University of Warwick found that when the chemical, Sodium Formate, is used in combination with a metal-based cancer treatment it can greatly increase its ability to shut down cancer cells. (
  • The Warwick researchers developed a novel method for binding Sodium Formate with JS07 to form a more potent form of the drug. (
  • The discovery also allows the researchers to make variations of the psammaplin A chemical and to use these variants to further understand the anti-cancer activity of this natural product. (
  • Researchers have been looking at the effects of drugs on fish over the course of several years, and the results show evidence that the drugs humans use are harming fish. (
  • Swedish researchers tested an anti-anxiety drug called oxazepam (found in water sources) on perch in the lab. (
  • Breast cancer researchers from the Florida campus of The Scripps Research Institute (TSRI) have developed a novel approach for identifying how chemicals in the environment - called environmental estrogens - can produce infertility , abnormal reproductive development, including "precocious puberty ," and promote breast cancer. (
  • They found that by combining data about structural disturbances from many structures with activity profiles of their ligands (the estrogenic chemicals), researchers can identify the sub-ångström details that determine endocrine disruption. (
  • Researchers at the University of North Carolina began testing soaps after local nurses noticed an unusual uptick in positive drug tests on infants. (
  • Researchers added that less than 0.1 mililiters of these chemicals in a drug test sample could contaminate the results. (
  • To overcome this hurdle, researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. (
  • First, researchers generate RNAi drugs with a sequence that corresponds to the gene blueprint for the disease protein and then delivers them into cells. (
  • That problem in the brain may be corrected by low doses of drugs used to treat anxiety and epileptic seizures, researchers from the University of Washington say. (
  • As the researchers call for immediate clinical trials, Astra-Zeneca has begun testing benzodiazepines and newer such drugs on people with autism. (
  • A study just published in the journal Substance Use & Misuse by researchers affiliated with New York University's Center for Drug Use and HIV Research (CDUHR), examined a national sample of high school seniors to determine who is currently at high risk for ecstasy use. (
  • Results suggest that while there are many important sociodemographic factors associated with ecstasy use, the researchers note that prevention of other drug use may be the most important factor in preventing ecstasy use, in part, because use of other drugs appears to override protective effects of certain characteristics. (
  • Given the positive expectations of experiences many adolescents associate with ecstasy, the researchers say that prevention efforts should focus on educating adolescents and young adults at highest risk with regard to the potential harmful effects of ecstasy, and just as importantly, education needs to continue to focus on preventing use of drugs that normally precede ecstasy use. (
  • A battle with chemical dependency may feel hopeless, but there is help available! (
  • The Brainerd Lakes Area is home to several programs for rehabilitation and chemical dependency care including medical care, counseling, and in patient treatment program. (
  • The chemical dependency team and addiction recovery services at Essentia Health-St. Joseph's Medical. (
  • Several relapse warning signs appear before you fall completely back into chemical dependency. (
  • Chemical dependency is a mental, emotional, physical and spiritual problem and must be treated as such for successful recovery. (
  • The chemical industry is already accustomed to tight controls over the smaller-volume domestic trade in pharmaceutical precursors, or chemical intermediates. (
  • It has been used to synthesize Musk 105 , 10-hydroxy-2-decylenic acid (queen acid) , as the intermediates of new drug for resistance to senile dementia -idebenone, and other medicine ,etc. (
  • While others have envisioned a causal role for psychotropic drugs in idiopathic autism, we were astonished to find evidence that this might occur at very low dosages, such as those found in aquatic systems," said lead scientist Dr Michael Thomas. (
  • The Waynesville Police Department receives about a dozen calls a week related to synthetic drugs, which in essence are plants that have been sprayed with a number of unknown chemicals and psychotropic drugs, Hollingsed said. (
  • The congressional subcommittee's list includes chemical precursors, such as ephedrine and pseudoephedrine, which are used widely to make non- prescription pharmaceuticals. (
  • Chemicals in pharmaceuticals such as anti-seizure medications and anti-depressants may also contribute, since they mimic estrogen. (
  • Drugs and Pharmaceuticals: Safety Considerations. (
  • Given their ubiquitous existence in the environment and our consumer products, it is challenging to entirely avoid exposures to these chemicals, although choosing products that are free of PFAS can help reduce the exposure," Sun said. (
  • 4) Drug exposure to the nursing infant may be minimized by having the mother take the medication just after she has breast-fed the infant and/or just before the infant is due to have a lengthy sleep period. (
  • The new research shows how high-resolution imaging techniques could give scientists a window into how exposure to these chemicals may impact public health. (
  • Exposure to a wide variety of chemicals and drugs has become common in industrial, laboratory, and even household environments. (
  • Drug and Chemical Toxicology is a quarterly peer-reviewed medical journal that publishes full-length research papers, review articles, and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. (
  • Edward was diagnosed as suffering from severe Aplastic Anaemia in April 1986 following exposure to a number of toxic chemicals at his workplace and, although it was not recognised by us at the time, he also suffered several of the documented symptoms of chemical poisoning (memory loss, jaundice, extreme fatigue etc.) in the weeks and months before diagnosis. (
  • During our investigations it became increasingly obvious that serious and often fatal blood disorders resulting from exposure to drugs, chemicals and radiation - with implications that these conditions are pre-cancerous - could often be avoided with public awareness. (
  • Such drugs when combined with the clinically approved drugs, would give a wider set of drugs to tackle MEN2, a second line of defence if/when patient relapse occurs and it would allow more diverse approaches for MEN2 treatment involving drug holidays, where short exposure to varying types of RET inhibitors, reduce the opportunity for drug resistance arising. (
  • Nettles and his colleagues reasoned that they could use a similar approach with x-ray crystallography to compare molecular snapshots, or structures, and better understand how estrogenic chemicals control receptor activity. (
  • Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel," Molecular Cancer Therapeutics , vol. 5, no. 4, pp. 853-867, 2006. (
  • Many current approaches use nanoparticles to deliver RNAi drugs into cells," said Steven F. Dowdy, PhD, professor in the Department of Cellular and Molecular Medicine and the study's principal investigator. (
  • While nanotechnology protects the RNAi drug, from a molecular perspective nanoparticles are huge, some 5,000 times larger than the RNAi drug itself. (
  • As for the solving of this task, it may be reached only in the case of successful fundamental studies of mechanisms of toxic action of different classes of chemicals performed at different biological levels (systemic, organ/tissue, cellular and molecular levels of research). (
  • By analyzing the correlation patterns between GPCRs and ligands, we can gain more detailed knowledge about their conserved molecular recognition patterns and improve drug design efforts by focusing on inferred candidates for GPCR-specific drugs. (
  • Jeremy Smith, Governor's Chair for Molecular Biophysics at the University of Tennessee, Knoxville, and director of the Center for Molecular Biophysics at Oak Ridge National Laboratory, has worked with a research team from the UT Health Science Center to discover a chemical compound that could lower sugar levels as effectively as the diabetes drug metformin but with a lower dose. (
  • This category lists articles that have a second identifier in {{Infobox drug}} , introducing a second chemical substance. (
  • Mix drugs with an undesirable substance, such as cat litter or used coffee grounds. (
  • And [two], standard drug tests provide society with very little useful information regarding whether someone actually used a particular substance, when they last used a particular substance, or whether they were impaired at the time they were tested. (
  • The way the drugs are made and sold one can never be sure what type of chemicals the substance contains, he added. (
  • The police receive calls either when parents find the substance among their children's possessions or a child has grown suddenly violent or passed out as a result of ingesting synthetic drugs. (
  • CRISPR/Cas9-based screens, which are largely limited to a gene's loss of function, have already been very successful in identifying drug targets and pathways related to the drug's mode of action. (
  • After exposing fish to two different anti-depressant drugs, Prozac and venlafaxine, and a seizure-controlling drug called carbamazepine, experts from the University of Idaho were 'astonished' after observing changes in the genetic pathways of the fish. (
  • Some adverse events are predictable consequences of the known mechanism of a drug, but others are not predicted and seem to result from 'off-target' pathways. (
  • It is not surprising that evolutionary relationships might lead to shared drug-binding capabilities in protein paralogs found across a wide range of cell types and biological pathways. (
  • Developed by Warwick's Department of Chemistry, the drug, a compound of the metal ruthenium called JS07, is capable of exploiting a cancer cell's natural weaknesses and disrupts its energy generation mechanism. (
  • Innovative drug is defined as a chemical compound with new and clearly defined structure, pharmacological property(ies) and apparent clinical value. (
  • In a study published online Dec. 3 in the Journal of Pharmacology and Experimental Therapeutics, scientists from the University of Michigan report that a compound called benzodiazepine-423 (Bz-423)---a chemical cousin of the anti-anxiety drugs Valiumâ and Xanaxâ---suppresses cell growth in a model of psoriasis. (
  • However, there is no way to know the exact chemical make-up of a compound unless it is tested. (
  • To compound the problem, protein-ligand studies have found that a single drug can bind targets with vastly different pharmacology and that about 35% of known drugs have two or more targets [ 5 ]. (
  • Chemical compound shows promise as alternative to opioid pain. (
  • This chemical compound lowers sugar levels in mice as effectively as metformin, but with a 30-times lower dose," Smith said. (
  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. (
  • Gary D. Strahan uses physico-chemical techniques to understand biological systems relevant to pharmaceutical discovery and agricultural and natural product analyses. (
  • Dr Fuchter points out that the new chemical routes toward the natural product psammaplin A were developed with the particular view to preparing diverse variants for biological assessment. (
  • Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. (
  • It provides interaction data between GPCRs and their ligands, along with chemical information on the ligands, as well as biological information regarding GPCRs. (
  • These data are connected with each other in a relational database, allowing users in the field of Chemical Genomics research to easily retrieve such information from either biological or chemical starting points. (
  • The study, appearing in the Journal of Biological Chemistry , investigated how the drug nifurtimox works to kill off the trypanosome. (
  • Co-author of the study, Dr Shane Wilkinson from Queen Mary's School of Biological and Chemical Sciences, said: "Hopefully our research will lead to the development of anti-parasitic medicines which have fewer side effects than Nifurtimox and are more effective. (
  • Dr Wilkinson and his colleagues Dr Belinda Hall and Mr Christopher Bot from Queen Mary's School of Biological and Chemical Sciences focused their research on the characterisation of the breakdown product from nifurtimox. (
  • With the increasing prevalence of drug-resistant parasites, considerable interest now exists in the identification of new biological targets for the development of new malaria chemotherapeutics. (
  • Se SVT Västnytts inslag om Vinnova-projektet "Challenge-driven innovation - Next generation´s test system for faster and more secure biological evaluation of drugs, materials and chemicals" som Acreo deltar i. (
  • Some criminologists argue that the appearance of a lower recidivism rate in male sex offenders who take chemical castration treatment than in those who do not can be explained by factors other than biological effects of the medication. (
  • Like other animal model research, scientists theorize that unwanted drugs getting into our water supplies may also have negative health effects on humans, but without extensive studies, this is conjecture. (
  • Finally, because the stereochemistry of the principal metabolite of cimetidine and (S)-nicotine in small experimental animals is distinct from that observed in humans, it is likely that species variation in predominant FMO isoforms exist and this may have important consequences for the choice of experimental animals in human preclinical drug design and development programs. (
  • Thus, the results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis. (
  • This chemogenomic approach combined with latest sequencing technologies allows deconvolution of drug targets and characterization of drug-target binding interfaces at amino acid resolution, therefore nicely complementing existing biochemical approaches. (
  • drugs chemicals and approaches? (
  • We're a professional manufacturer of fine chemicals, a premium aerospace supplier, with 47 years history and 5 R&D bases. (
  • This book overturns the idea that psychiatric drugs work by correcting chemical imbalance and analyzes the professional, commercial and political vested interests that have shaped this view. (
  • New research gives hope to soon treating the "chemical imbalance" underlying autism spectrum disorder. (
  • The biology of autism spectrum disorder may be as simple as the "chemical imbalance" illustrated by cartoon blobs in Pfizer's classic 2002 commercial spot for Zoloft. (
  • After repeated use of addictive drugs it is progressively more difficult for the neurotransmitters to recover after the drugs wear off, which eventually creates a chemical imbalance in the brain. (
  • Pharmaceutical drugs are broken down by enzymes in the liver into their metabolites, which are subsequently excreted in the faeces and urine. (
  • In conjunction with asymmetric chemical syntheses and spectral, chiroptical, chromatographic and stereochemical correlation methods, we have developed procedures for the quantification of sulfoxide enantiomers and tertiary amine N-oxide diastereomer metabolites arising from the action of the adult human liver and other flavin-containing monooxygenases (FMOs). (
  • through a chemical process the liver breaks the drug down into by-products called metabolites. (
  • The fat tissue acts as a sponge to absorb the dangerous drug metabolites then slowly releases them back into the blood stream where they begin the process to be re-metabolized. (
  • urine is the primary body fluid used for drug screening. (
  • Our bodies absorb some of the drugs we take, but residual amounts pass through us (in our urine or stool) and are flushed down the toilet, although these amounts are very small in comparison. (
  • In other words, it would not be surprising to find trace amounts of these products in urine, saliva or hair follicles - putting a huge question mark on the validity of less expensive drug tests conducted by employers and law enforcement agencies around the nation. (
  • Only in an environment of criminal drug prohibition can people judged solely on the contents of their urine, rather than on their behavior and performance. (
  • This research method could also be used to speed up the discovery of new drugs for breast cancer and many other diseases, added study senior author Kendall Nettles, associate professor at TSRI. (
  • Drugs: Discovery and Development. (
  • But the real excitement of the discovery is the potential impact on a large class of peptide drugs, Gellman says. (
  • GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update. (
  • We hope that it will prove very useful for Chemical Genomics research and GPCR-related drug discovery. (
  • This new approach to diabetes drug discovery has been published in PLOS One , a peer-reviewed open access scientific journal. (
  • My own attitude is one of cautious optimism, which in drug discovery is usually the best you can have. (
  • They specifically highlighted the ingredients polyquaternium 11 and cocamidopropyl betaine as "showing strong reactivity" with chemicals in less expensive drug tests, producing the positive result for marijuana. (
  • The chemical reactivity of as-anodized porous silicon is shown to have an adverse effect on a model drug (Lansoprazole) loaded into the pores. (
  • Sailor MJ (2014) Chemical reactivity and surface chemistry of porous silicon. (
  • the study of the rates of chemical reactions. (
  • In their paper, the UCR chemists discuss a set of chemical reactions involving the use of catalysts other than those that are CAAC-based. (
  • All of this can dramatically reduce the cost of manufacturing drugs, given that pharmaceutical companies are increasingly using carbene-supported catalysts for their chemical reactions. (
  • Now it mostly appears when it's unintentionally produced from chemical reactions at industrial sites. (
  • Experts from the University of Nottingham have created a self-sustaining circuit of reactions which is a greener and more efficient method of chemical production. (
  • In their paper Self-sustaining closed-loop multienzyme mediated conversion of amines into alcohols in continuous reactions , published in Nature Catalysis , Drs Francesca Paradisi and Martina Contente of the University of Nottingham produce chemicals more efficiently through a looped set of reactions using enzymes in flow. (
  • Dr Paradisi, Associate Professor in Biocatalysis and Enzyme Engineering in the School of Chemistry, explained that water is often used as the medium in which enzyme mediated chemical reactions can take place but there is an issue in disposing of the waste at the end of the process. (
  • We also discovered that working in this way meant the yields of some "tricky to make" high-value products are also much higher than for traditional chemical reactions - by over 20-fold. (
  • For example, highly publicized cases of severe adverse reactions recently resulted in a US Food and Drug Administration advisory panel suggesting that the popular pain relievers Percocet and Vicodin be banned [ 2 ]. (
  • Royalty free and rights managed images of allergic reactions of drugs and other chemicals. (
  • The drug, a small molecule called TAK-935, inhibits the enzyme cholesterol 24-hydroxylase, which may have a role in central nervous system diseases such as epilepsy. (
  • Drugs and Human Diseases. (
  • Also, these chemicals may be industrial hazards promoting the origin and development of various occupational diseases. (
  • At present, resistance to the drugs used in the treatment of many infectious diseases is increasing, while microbial infections are being found to be responsible for more life threatening diseases than previously thought. (
  • Many myths, theories, and speculations exist as to the exact etiology of the diseases, drugs, and chemicals that affected the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. (
  • Diseases, drugs, and chemicals may have influenced their creativity and productivity. (
  • To calculate the market size, the report considers revenue generated from the sales of various prescription drugs along with the generic drugs used for the treatment of various infectious diseases caused by the different strains of bacteria. (
  • Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. (
  • We are confident that our results will lead to the development of a new, highly selective generation of Alzheimer's drugs," explained Demuth. (
  • Click chemistry for drug development and diverse chemical-biology applications. (
  • This change may incentivize multinational companies wishing to bring innovative drugs to China to start their product development in China earlier in the process than before in order to realize marketing advantages. (
  • Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. (
  • The combination of drugs with external devices to control light may contribute to the development of personalized medicine in which treatments can be adapted to each patient, limiting the time given regions are treated, thus markedly reducing unwanted effects. (
  • It therefore is a good starting point for the development of a new and effective drug to fight diabetes. (
  • our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and chemical manufacturing. (
  • My work presented here focuses on the development and use of chemical tools to study malarial proteases, a class of enzymes that have been shown to play essential roles throughout the parasite lifecycle, but the majority of which though are still uncharacterized. (
  • This drug resistance arises because the cancer cells mutate to shrug off the effectiveness of the anti-cancer drug, in an analogous process to the development of antibiotic resistance in bacteria. (
  • The prevalence of drug use is reiterated here to emphasize the vital role that toxicologic analysis plays in autopsy pathology. (
  • Although the incidence of false-positive results is low, such tests are less reliable when the prevalence of drug abuse is also low. (
  • To rid the workplace of drugs, the prevalence of drug abuse needs to be known as well as whether, in fact, such abuse is directly related to workplace outcomes, such as productivity, safety, and product integrity. (
  • While such reports tend to emphasize the seriousness of the drug abuse problem, they do not actually estimate the prevalence of drug use in the workplace. (
  • The study was published online ahead of print in the journal Cell Chemical Biology . (
  • Pathway mapping and modeling based on network biology concepts are a key component of the vision laid out in this report for a more biologically based analysis of dose-response behavior and the safety of chemicals and drugs. (
  • Chemical systems biology, or the application of systemwide tools to the analysis of pharmacological responses, can help address the lack of efficacy and undesired off-target effects [ 3 ]. (
  • 7 ]) have used a chemical systems biology approach to explain the serious side-effects of a drug that was being trialed for prevention of cardiovascular disease. (
  • Dr. Devi and her team are currently working with co-author Marta Filizola, PhD, Associate Professor of Structural and Chemical Biology at Mount Sinai, to learn how CYM51010 binds to the protein complex. (
  • Masamichi Tsuboi studies DNA and RNA structures, drug-DNA interaction, protein conformation, protein-nucleic acid recognition, and virus structure using a variety of physicochemical and biomedical techniques including X-ray diffraction, UV-Visible, IR/Raman , and NMR spectroscopy. (
  • By inducing single nucleotide changes using an alkylating reagent, it is possible to generate amino acid changes that perturb the interaction between a drug and its direct target, resulting in drug resistance. (
  • The number of confident predictions grows faster than the number of known structures, suggesting that this approach will play a key role in completing the protein-chemical interaction repertoire. (
  • Cancers that respond to the administration of this drug as part of a controlled chemotherapy regimen are Hodgkins Lymphoma, non-small cell lung cancer, head and neck cancer, breast cancer, and testicular cancer. (
  • Vinblastine has several interesting chemical properties in it's application as a chemotherapy drug regimen. (
  • The benefit to society, of course, would be that vinblastine is an effective chemotherapy drug, one that helps eradicate cancer cells by destroying the formation of those cancer cells within the confines of their reproductive cell cycle. (
  • One of the tests is designed to assist the dosage of some highly toxic drugs used in chemotherapy for cancer, a disease which causes almost a million deaths in the EU every year. (
  • Chemical modifications can cause the drug to have both beneficial and adverse effects on patients. (
  • Drug-related adverse events affect approximately 2 million patients in the United States each year, resulting in about 100,000 deaths [ 1 ]. (
  • The laboratory assays currently used to evaluate potential adverse drug effects can be costly and time-consuming. (
  • The research recorded a continuation of this more positive behaviour after the administration of the drug had ended with no evidence of adverse side effects and recommended medroxyprogesterone acetate along with counselling as a successful method of treatment for serial sex offenders. (
  • Interestingly, psammaplin A and our man-made variants show high selectivity in lab-based experiments, which is an important feature for the design and manufacture of future drugs. (
  • The basic premise is that two proteins sharing a common bound chemical will likely share others. (
  • We show for a benchmark that known protein-chemical structures are reconstructed with good accuracy and sometimes via very different proteins and chemicals. (
  • We exploited the basic premise that if two proteins in the network share one bound chemical they are likely to share others. (
  • A single prediction candidate ( Figure 1 ) involves combining three protein-chemical complex structures, two of which involve two distinct proteins (P 1 and P 2 ) binding a common ligand (L a ) and a third where one protein (P 1 ) binds another ligand (L b ). (
  • Traditionally, the oral route cannot be employed for the delivery of macromolecular drugs such as proteins and peptides due, in large part, to limited transport across the epithelial membrane. (
  • NUS pharmaceutical scientists have discovered the mechanisms involved when small chemical modifications to certain pharmaceutical drugs may cause harm instead of improving treatment. (
  • The indexer can also go to the MeSH Browser, type the name of the chemical, and search for the exact term. (
  • Our approach could prove crucial to stimulate the search for a second and third generation of improved drugs to treat MEN2 disease and to help benefit patients. (
  • In cities and towns that use wastewater treatment plants, prescription and over-the-counter drugs are poured down the sink or flushed down the toilet, pass through the treatment system, and then may enter rivers and lakes. (
  • will place you in contact with a trained advisor from one of our sponsoring treatment providers. (
  • It is a concise, powerful, well-referenced and well-constructed critique of psychiatric drug treatment. (
  • This means that these drugs, modified to enhance treatment, may instead be undesirable for the patient. (
  • Vinblastine is an antimicrotubule drug used in the treatment of various kinds of cancer. (
  • These are very exciting results because they suggest that existing drugs - called benzodiazepines - might be useful in treatment of the core deficits in autism," senior study leader William Catterall said in a statement . (
  • drugs chemicals for' seller' in Psycholinguistic treatment. (
  • Metformin, a drug that lowers the liver's production of sugar and decreases risk of mortality, is currently recommended as a first-line treatment. (
  • Eventually the drug user is completely addicted and it becomes nearly impossible to stop taking the drugs without a comprehensive treatment program. (
  • These types of treatment programs begin treatment with a holistic detox that help cleans the body of drug deposits accumulated in the fat cells. (
  • Chemical castration is generally considered reversible when treatment is discontinued, although permanent effects in body chemistry can sometimes be seen, as in the case of bone density loss increasing with length of use of DMPA. (
  • One hypothesis is that men who accept the negative effects of hormonal treatment in exchange for shorter prison sentence are distinct in that they value freedom from incarceration higher than men who rather stay in prison for a longer time than face the side effects of chemical castration. (
  • A recent review by Giordano and Petrelli, for example, describes their approach to developing multi-target drugs for cancer therapy while avoiding drug resistance by targeting multiple tyrosine kinase receptors [ 6 ]. (
  • MeSH contains thousands of chemicals, so it is likely that the specific chemical in a given article can be found by searching the MeSH Browser. (
  • For example, the drug Propranolol can be readily found using either method. (
  • The Introduction and Epidemiology sections have both mentioned that drugs are found in 50% of forensic autopsies (when tested) and that drugs or medications are responsible for causing or contributing to death in over 20% of deaths unrelated to natural causes in the United States. (
  • The study can't prove cause-and-effect, but "found that individuals with higher blood levels of these chemicals had more difficulties of maintaining weight loss after dieting," said study lead author Dr. Qi Sun. "This pattern is primarily observed in women. (
  • A report in a recent edition of Organic & Biomolecular Chemistry , the journal of the Royal Society of Chemistry, described how a young scientist from Imperial College London had been awarded a grant of £106,079 to investigate naturally occurring chemicals found in sea sponges in an effort to find out more about anti-cancer drugs. (
  • More detailed information on specific chemicals and families of chemicals can be found in their respective articles. (
  • They found that just traces of common medications and other chemicals in the water were enough to bring about autism. (
  • There, Dowdy's team found that siRNNs were significantly more effective at blocking target protein production than typical RNAi drugs - demonstrating that once siRNNs get inside a cell they can do a better job. (
  • Studies found that the effect of another brain chemical called glutamate, which when perturbed is thought to cause dyskinesias, was also inhibited through by this drug. (
  • Police, local radio RPP said, found drug making chemicals and supplies, including 620 kilograms of sulfuric acid, 720 kilograms of kerosene, 600 kilograms of formic acid, 100 kilograms of calcium oxide, and 10 kilograms of baking soda. (
  • Smith's computations found several chemicals that might activate the protein, and the Quarles laboratory at UTHSC tested each. (
  • No clear sex-related differences in individual P-450 contents and drug- and carcinogen-metabolizing activities were detected in 60 human samples, except that P-450 1A2-dependent activities were found to be higher in mean than in women in the Caucasian population only. (
  • We delineated many important sociodemographic risk factors, but the most consistent and important risk factor we found is use of other drugs. (
  • We are leading suppliers of laboratory chemicals, plastic wares, glass wares, instruments and equipments, in jaipur and rajasthan. (
  • Unfortunately, due to their size and negatively charged chemical groups (phosphates) on their backbone, RNAi drugs are repelled by the cellular membrane and cannot be delivered into cells without a special delivery agent. (
  • Potentially, the "alter-the-backbone" strategy could allow oral dosing of the rather fragile peptide drugs, which today must be injected to avoid destruction in the stomach and small intestine. (
  • The backbone of nifurtimox contains a chemical group called a nitro linked to a ring structure called a furan," Dr Wilkinson explained. (
  • Late king of Pop Michael Jackson had a "chemical castration" drug to suppress his sexual urges towards under-age boys, if reports are to be believed. (
  • Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. (
  • Unlike surgical castration, where the gonads are removed through an incision in the body, chemical castration does not remove organs, nor is it a form of sterilization. (
  • The first use of chemical castration occurred in 1944, when diethylstilbestrol was used with the purpose of lowering men's testosterone. (
  • Chemical castration is often seen as an easier alternative to life imprisonment or the death penalty because it allows the release of sex offenders while reducing or eliminating the chance that they reoffend. (
  • These scientists explain apparently lower recidivism as an artifact of men who accept chemical castration being more engaged in hiding the evidence for reoffending, and that paroling such offenders constitute a risk of releasing criminals who commit as many new crimes as others but are better at hiding it. (
  • Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. (
  • Entire textbooks have been written on forensic toxicology and individual drugs and chemicals that can cause death. (
  • He is also the editor of Toxicology of Pesticides in Animals, and author of Safety Evaluation of Environmental Chemicals. (
  • Smith, together with Jerome Baudry, of the University of Alabama at Huntsville, and graduate student Karan Kapoor, of the University of Illinois at Urbana-Champaign, used high-performance computing to create sophisticated simulations to suggest chemicals that could activate GPRC6A, a protein that regulates sugar levels by simultaneously correcting abnormalities in pancreatic insulin secretion, glucose uptake into skeletal muscle, and liver regulation of glucose and fat metabolism. (
  • There are three, 5 inch bottles labeled as follows: LIVER SPECIAL, CATARRH CHRONIC, and MERCURY PROTO IODIDE (the Mercury example mentions the Food and Drugs Act of 1906 on the label. (
  • A new drug candidate previously shown to reduce harmful side effects of the autoimmune disease lupus also may be useful in treating psoriasis. (
  • The book explains the beneficial and harmful aspects of a broad range of materials to which students, trainees, skilled workers, managers, and personnel associated with regulatory agencies are exposed, with the purpose of helping them avoid the illnesses associated with the misuse of chemicals and drugs. (
  • The drug detoxification is achieved through a strict regimen of vitamins, minerals and other natural supplements in combination with exercise, and a low temperature sauna which rids the body of the harmful drug residue. (
  • The team's preliminary results indicate that these psammaplin A variants are more potent than the natural product and that they could well form the basis of new selective drugs in the future. (
  • The sheer volume of trade in some of these chemicals, such as acetone, of which 4 billion pounds a year are produced by 10 major global companies, will complicate a reporting requirement that is not selective. (
  • Currently, the best treatments for skin lesions associated with psoriasis are topical steroids, but the problem with those drugs is that they're not selective for the disease-causing cells. (
  • Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. (
  • Some of them produce effects similar to illegal drugs. (
  • Until we have conclusive studies analyzing the effects of unwanted drugs in our water, it is best to be safe and install a water filter. (
  • There are also protein drugs approved for use in treating psoriasis, but those drugs are injected instead of applied topically, which makes them more costly, less convenient and more likely to cause side effects since they are delivered throughout the body. (
  • The Waynesville Police Department, in cooperation with residents, schools and other law enforcement agencies, has started hosting meetings around Haywood County to generate greater awareness of synthetic drugs and their side effects. (
  • A study was commissioned to investigate the consequences of the use of BZP as a recreational drug but it was abandoned because of the unpleasant side effects reported by volunteers. (
  • it] is far from one-sided, and argues that rather than discarding drugs we should use them properly and concentrate on their effects rather than upon traditional but ultimately unscientific assumptions. (
  • Finally, the numerous side effects of multiple new drugs may serve as causes of a number of different health disorders. (
  • Informative guides on ecstasy, ecstasy effects, ecstasy pills, ecstasy dangers, ecstasy drug tests, mixing ecstasy with other drugs and the legality of ecstacy. (
  • Learn the risks and effects of abusing inhaled chemicals. (
  • Know the basics about ketamine, as well as understand ketamine effects, ketamine addiction, ketamine dangers, ketamine drug tests, and the results of ketamine mixing with other drugs. (
  • Traditional drug design has relied heavily on the one drug-one target paradigm [ 3 ], but this may overlook system-wide effects that cause the drug to be unsuccessful. (
  • A systems view of the body's responses to a drug threatens the simplicity of the one drug-one target paradigm, but could provide a framework for considering all effects, and not just those that are targeted. (
  • The AUL model ensures that women considering a drug-induced abortion receives comprehensive information on abortion-inducing drugs, including the potential to reverse the effects of the drugs should she change her mind. (
  • This study will examine the effects of certain investigational anti-cancer drugs on the genetic and protein makeup of cells. (
  • and 2) predict which patients will have a greater chance of developing side effects or a greater chance of benefiting from the drug. (
  • A drug may be sterilised, but not necessarily free from all traces of bacteria and this can lead to side-effects such as fever, pain and shock. (
  • Addictive drugs produce similar effects in the brain as the natural chemicals. (
  • All these side effects are extremely painful, and will usually drive a person to go back taking the very drugs that have caused the pain. (
  • Scientists have uncovered the mechanisms behind a drug used to treat African sleeping sickness and Chagas disease, infections caused by trypanosome parasites which result in 60,000 deaths each year. (
  • His work has emphasized spectroscopic methods, NMR, and computational modeling to determine the structures and properties of multistranded DNA, drug-DNA complexes, carbohydrates, and other biomolecules, as well as metabonomic and chemometric studies. (
  • The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential. (
  • Blood is also the way we get rid of waste products of cellular metabolism (endogenous toxins), and chemicals, drugs and toxins from exogenous sources. (
  • The Food and Drug Administration (FDA) announced it's currently testing the widely used diabetes drug metformin for a cancer-causing contaminant known as N-nitrosodimethylamine (NDMA). (
  • In fact, changes to even a single atom in a chemical or endocrine therapy drug can often drive widely divergent outcomes, but the resolution of the typical crystal structure does not allow visualization of these small changes. (
  • Affymax and its Japanese partner Takeda Pharmaceutical have voluntarily recalled the anemia drug Omontys after about a year on the U.S. market. (
  • In a reverse of the usual big pharma-biotech relationship, the New York City-based biotech firm Ovid Therapeutics will help develop a Takeda Pharmaceutical drug for rare pediatric epilepsy. (
  • The DEA says the products are made of plant material coated with chemicals that claim to mimic THC, the key ingredient in marijuana. (
  • provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (
  • It may contaminate the products during the manufacturing process or through how the drugs are stored or packed. (
  • The chemicals are not in any way related to marijuana and both are used in hundreds of products like toothpaste, shampoo, makeup, hair dye and household cleaning agents. (
  • They chose to add an additional category (Class D) to their misuse of drugs legislation, based on that in the UK, and introduced an age-related prohibition on the sale of BZP and related products. (
  • Guidance for industry : incorporation of physical-chemical identifiers into solid oral dosage form drug products for anticounterfeiting. (
  • I thought you might be interested in this item at Title: Guidance for industry : incorporation of physical-chemical identifiers into solid oral dosage form drug products for anticounterfeiting. (
  • Pharmaceutical and chemicals companies have to demonstrate that the drug products they are developing are reproducibly effective and efficient, meeting their desired Quality Target Product Profile (QTPP). (
  • We are leading manufacturer and exporter of industrial chemical, chemical and chemical products, acids, etc. (
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  • This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy. (
  • The UTHSC team verified its potency and used this starting point to design an even more effective chemical . (
  • The image is from an article about computer-aided design and it looks both like a major communications failure (chemical-free drugs, anyone? (
  • as well as a massive dollop of hype about computer-aided drug design. (
  • It's intriguing to consider both how we are still considering pretty much the same questions about computational drug design that we were in 1981 as well as how much progress we have made on various fronts since then. (
  • The part about drug design was almost a throwaway with almost no explanation in the text. (
  • One application requiring massive parallel sequencing is forward genetic screening based on chemical mutagenesis. (
  • Here we describe a general protocol for a chemical mutagenesis-based forward genetic screen applicable for drug-target deconvolution. (
  • Vasconcelos, V. Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge. (
  • However, it is a less known fact that the same alterations may worsen drug toxicities as an unintended effect. (
  • A separate and special population of modern health-hazardous chemicals is a group of agents which selectively suppress protein synthesis in mammalian cells and tissues due to the direct effect on the translation machinery elements or on the messenger RNA processing steps. (
  • People will go to great lengths to get more of the drugs to reach that high, and suppress the painful symptoms of withdrawal. (
  • The results presented here emphasize the importance of understanding enhancer mechanism and uncover a zwitterionic surfactant capable of safely and effectively achieving intraepithelial drug delivery in vitro . (
  • Neurospecific translation control and the problem of potent danger of drugs and chemicals: a caution. (