A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Persistent and disabling ANXIETY.
Those disorders that have a disturbance in mood as their predominant feature.
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.
Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.
Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
Disorders related to substance abuse.
A repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate societal norms or rules are violated. These behaviors include aggressive conduct that causes or threatens physical harm to other people or animals, nonaggressive conduct that causes property loss or damage, deceitfulness or theft, and serious violations of rules. The onset is before age 18. (From DSM-IV, 1994)
Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)
Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Disorders related to or resulting from abuse or mis-use of alcohol.
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.
Neurotic reactions to unusual, severe, or overwhelming military stress.
Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.
Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)
A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)
Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.
Sudden temporary alterations in the normally integrative functions of consciousness.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributing to the complexity of temporomandibular diseases are its relation to dentition and mastication and the symptomatic effects in other areas which account for referred pain to the joint and the difficulties in applying traditional diagnostic procedures to temporomandibular joint pathology where tissue is rarely obtained and x-rays are often inadequate or nonspecific. Common diseases are developmental abnormalities, trauma, subluxation, luxation, arthritis, and neoplasia. (From Thoma's Oral Pathology, 6th ed, pp577-600)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A disorder whose predominant feature is a loss or alteration in physical functioning that suggests a physical disorder but that is actually a direct expression of a psychological conflict or need.
Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These disorders may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Disorders in which the symptoms are distressing to the individual and recognized by him or her as being unacceptable. Social relationships may be greatly affected but usually remain within acceptable limits. The disturbance is relatively enduring or recurrent without treatment.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Agents that are used to treat bipolar disorders or mania associated with other affective disorders.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
A characteristic symptom complex.
Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.
The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.
Maladaptive reactions to identifiable psychosocial stressors occurring within a short time after onset of the stressor. They are manifested by either impairment in social or occupational functioning or by symptoms (depression, anxiety, etc.) that are in excess of a normal and expected reaction to the stressor.
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Conditions characterized by deficiencies of comprehension or expression of written and spoken forms of language. These include acquired and developmental disorders.
An eating disorder that is characterized by a cycle of binge eating (BULIMIA or bingeing) followed by inappropriate acts (purging) to avert weight gain. Purging methods often include self-induced VOMITING, use of LAXATIVES or DIURETICS, excessive exercise, and FASTING.
Preoccupations with appearance or self-image causing significant distress or impairment in important areas of functioning.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
An umbrella term used to describe a pattern of disabilities and abnormalities that result from fetal exposure to ETHANOL during pregnancy. It encompasses a phenotypic range that can vary greatly between individuals, but reliably includes one or more of the following: characteristic facial dysmorphism, FETAL GROWTH RETARDATION, central nervous system abnormalities, cognitive and/or behavioral dysfunction, BIRTH DEFECTS. The level of maternal alcohol consumption does not necessarily correlate directly with disease severity.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.
A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Obsessive, persistent, intense fear of open places.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Disorders characterized by physical or psychological symptoms that are not real, genuine, or natural.
Assessment of psychological variables by the application of mathematical procedures.
Conditions characterized by language abilities (comprehension and expression of speech and writing) that are below the expected level for a given age, generally in the absence of an intellectual impairment. These conditions may be associated with DEAFNESS; BRAIN DISEASES; MENTAL DISORDERS; or environmental factors.
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
Disorders caused by abnormalities in platelet count or function.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.
Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Pathological processes that affect voice production, usually involving VOCAL CORDS and the LARYNGEAL MUCOSA. Voice disorders can be caused by organic (anatomical), or functional (emotional or psychological) factors leading to DYSPHONIA; APHONIA; and defects in VOICE QUALITY, loudness, and pitch.
A disorder beginning in childhood whose essential features are persistent impairment in reciprocal social communication and social interaction, and restricted, repetitive patterns of behavior, interests, or activities. These symptoms may limit or impair everyday functioning. (From DSM-5)
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
Marked impairments in the development of motor coordination such that the impairment interferes with activities of daily living. (From DSM-V)
Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.
Elements of limited time intervals, contributing to particular results or situations.
An affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.
Disorder characterized by an emotionally constricted manner that is unduly conventional, serious, formal, and stingy, by preoccupation with trivial details, rules, order, organization, schedules, and lists, by stubborn insistence on having things one's own way without regard for the effects on others, by poor interpersonal relationships, and by indecisiveness due to fear of making mistakes.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Disorders stemming from the misuse and abuse of alcohol.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.
Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, trauma, or other causes.
An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
A class of traumatic stress disorders that is characterized by the significant dissociative states seen immediately after overwhelming trauma. By definition it cannot last longer than 1 month, if it persists, a diagnosis of post-traumatic stress disorder (STRESS DISORDERS, POST-TRAUMATIC) is more appropriate.
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
Study of mental processes and behavior of schizophrenics.
Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.
A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)
Stress wherein emotional factors predominate.
Behaviors which are at variance with the expected social norm and which affect other individuals.
Inorganic compounds that contain lithium as an integral part of the molecule.
The unsuccessful attempt to kill oneself.
Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information contained in auditory stimuli despite intact auditory pathways. Affected individuals have difficulty with speech perception, sound localization, and comprehending the meaning of inflections of speech.
Child with one or more parents afflicted by a physical or mental disorder.
Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.
Conditions characterized by an alteration in gustatory function or perception. Taste disorders are frequently associated with OLFACTION DISORDERS. Additional potential etiologies include METABOLIC DISEASES; DRUG TOXICITY; and taste pathway disorders (e.g., TASTE BUD diseases; FACIAL NERVE DISEASES; GLOSSOPHARYNGEAL NERVE DISEASES; and BRAIN STEM diseases).
The study of significant causes and processes in the development of mental illness.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.
An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.
Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as "ox hunger".
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.
Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.
Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
Injury, weakening, or PROLAPSE of the pelvic muscles, surrounding connective tissues or ligaments (PELVIC FLOOR).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Those affective states which can be experienced and have arousing and motivational properties.
The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.
A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
Organized services to provide mental health care.
Pathological conditions resulting from abnormal anabolism or catabolism of lipids in the body.
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Disorders affecting TWINS, one or both, at any age.
Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Disruptions of the rhythmic cycle of bodily functions or activities.
An infant during the first month after birth.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body.
Acquired and inherited conditions that feature DYSTONIA as a primary manifestation of disease. These disorders are generally divided into generalized dystonias (e.g., dystonia musculorum deformans) and focal dystonias (e.g., writer's cramp). They are also classified by patterns of inheritance and by age of onset.
Disorders of the quality of speech characterized by the substitution, omission, distortion, and addition of phonemes.
Biochemical identification of mutational changes in a nucleotide sequence.
Any behavior caused by or affecting another individual, usually of the same species.
A false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one's associates.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The act of killing oneself.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
Inborn errors of metabolism characterized by defects in specific lysosomal hydrolases and resulting in intracellular accumulation of unmetabolized substrates.
Former members of the armed services.
Theoretical representations that simulate psychological processes and/or social processes. These include the use of mathematical equations, computers, and other electronic equipment.
Genes that influence the PHENOTYPE only in the homozygous state.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.
Individuals' concept of their own bodies.
Mood or emotional responses dissonant with or inappropriate to the behavior and/or stimulus.
Congenital conditions in individuals with a male karyotype, in which the development of the gonadal or anatomical sex is atypical.
Behavior-response patterns that characterize the individual.
Intellectual or mental process whereby an organism obtains knowledge.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.
Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Inherited disorders characterized by progressive atrophy and dysfunction of anatomically or physiologically related neurologic systems.
Anxiety disorders manifested by the development of characteristic symptoms following a psychologically traumatic event that is outside the normal range of usual human experience. Symptoms include re-experiencing the traumatic event, increased arousal, and numbing of responsiveness to or reduced involvement with the external world. Traumatic stress disorders can be further classified by the time of onset and the duration of these symptoms.

Identification of workers exposed concomitantly to heat stress and chemicals. (1/2)

In the context of climate change, concomitant exposure to heat stress and chemicals takes on great importance. However, little information is available in this regard. The purpose of this research, therefore, was to develop an approach aimed at identifying worker groups that would be potentially most at risk. The approach comprises 5 consecutive steps: - Establishment of a list of occupations for all industry sectors - Determination of heat stress parameters - Identification of occupations at risk of heat stress - Determination of exposure to chemicals - Identification of occupations potentially most at risk. Overall, 1,010 occupations were selected due to their representativeness of employment sectors in Quebec. Using a rating matrix, the risk stemming from exposure to heat stress was judged "critical" or "significant" for 257 occupations. Among these, 136 occupations were identified as showing a high potential of simultaneous exposure to heat stress and chemicals. Lastly, a consultation with thirteen experts made it possible to establish a list of 22 priority occupations, that is, 20 occupations in the metal manufacturing sector, as well as roofers and firefighters. These occupations would merit special attention for an investigation and evaluation of the potential effects on workers' health.  (+info)

Student preferences regarding teaching methods in a drug-induced diseases and clinical toxicology course. (2/2)


Drug-induced diseases are unintended effects of drugs that result in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical attention and/or require hospitalization. Drug-Induced Diseases provides a detailed overview of diseases that result from drug therapy, arming healthcare professionals with critical knowledge to protect the health and welfare of their patients. Now in its third edition, this important reference helps healthcare practitioners, residents, and students by expanding the understanding of disease state causes and effects, encouraging critical thinking, and raising awareness that many diseases can be caused or exacerbated by a medication the patient is taking. The third edition has been revised and expanded, and includes: 58 peer-reviewed chapters authored by 99 contributors Detailed, comprehensive tables New chapters including Bleeding Disorders, Teratogenicity, and Oral Manifestations of Systemically Administered Drugs Comprehensive coverage of ...
10. The European Union legislation on substances and mixtures - Regulation No 1907/2006 (REACH), Directive 67/548/EEC, Regulation No 1272/2008 (CLP). The Czech legislation on substances and mixtures, the public health protection, occupational safety and health protection, and the prevention of major accidents. Permissible exposure levels and short-term exposure limits of chemicals and dusts in the air in the working zone, permissible concentrations of chemicals and dusts in indoor environment, maximum permissible concentrations of substances in drinking water, maximum residue levels in food ...
Watch the video lecture Amphetamines - Drugs of Abuse & boost your knowledge! Study for your classes, USMLE, MCAT or MBBS. Learn online with high-yield video lectures by world-class professors & earn perfect scores. Save time & study efficiently. ➨ Try now for free! Online Learning with Lecturio - anytime, anywhere
Abstract. The etiology of cardiomyopathies are classified into 4 main groupings (dilated, hypertrophic, restrictive, and idiopathic) and can be mechanistically caused by myocarditis, conduction abnormalities, focal direct injury, or nutritional deficiency. Based on our review of this topic, evidence suggests that echinocandin-related cardiac dysfunction is a mitochondrial drug-induced disease caused by focal direct myocyte injury. With caspofungin or anidulafungin administration into the heart via central line, exposure is likely extreme enough to induce the acute toxicity. Chronic or low-dose exposure may lead to hypertrophic cardiomyopathy; however, only acute exposures have been explored to date.. KEYWORDS: cardiac output; cardiac toxicity; echinocandin; echocardiography. PMID: 26567285. Supplements. The Mycotic Research Center at the University of Mississippi Medical Center has long focused on augmenting the knowledge of antifungal drugs to maximize safety and minimize toxicity. In 2008, ...
We hear much these days about our young adults being indoctrinated into cults, not realizing that we all can become indoctrinated into a cult or special interest group or school of thought of some sort if we fail to recognize the difference between indoctrination and education and the techniques applied by both.. Our nation today faces a serious threat of being incapacitated, even annihilated by drugs. Most of us have been indoctrinated into drugs and drug medicine since youth. Our nations drug problem is an extension of our drug mentality. We accept drugs, we think theyre good, we believe in them, and most of us do not think there is an alternative. Were locked into a system that is now responsible for more sickness and disease than it is helping. This irony is iatrogenic, or drug-induced disease.. Because the news media is controlled by the medical establishment, for your own health, safety and future it is vital that you become aware of the fact that when we read a report or watch medical ...
One crucial warning is in order. Looking at the number of users of the various psychoactive drugs and their frequency of use is one crucial piece of the drug puzzle. Its possible, however, that there is a much more important piece of the puzzle: societys addicts. It can be argued that the occasional or less-than-weekly drug user rarely poses a comparably serious threat of harm to the society. It is entirely possible that the public health issue, as well as the issue of any and all potential dangers that drug use poses to the society, is more or less entirely confined to the heavy or chronic user. The less-than-weekly user of even heroin and cocaine is much less likely to rob to support a drug habit; die of an overdose; contract a serious, life-threatening, drug-induced disease; or kill someone in connection with drug use. It could be that the harms we associate with drug use and abuse are mostly confined to that segment of users we refer to as the behaviorally dependent in a word, to ...
Carotenoids have been implicated in numerous epidemiological studies as being protective against cancer at many sites, and their chemopreventive properties have been confirmed in laboratory studies. Astaxanthin (AST), primarily a carotenoid of marine origin, responsible for the pink coloration of sa …
Aims (i)protection against development of spontaneous and chemically-induced tumors in animal systems (ii)identification of targets for immune recognition of human cancer
11. Sensory Systems Chapter Editor: Heikki Savolainen Table of Contents Tables and Figures The EarMarcel-André Boillat Chemically-Induced Hearing Dis...
Free Course on Cell Damage and Tissue Repair, Reversible Cell Damage, Lethal Injury (Cell Death), Homeostasis, Toxicity & Neurotoxicity. Toxicology , Toxicology education, Toxicology Programs, study Toxicology , Toxicology exams, Toxicology major, major in Toxicology , Toxicology certification exams, career info on Toxicology , admissions in Toxicology schools, Toxicology Degrees
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening, immunologically mediated, and usually drug-induced disease with a high burden to individuals, their families, and society with an annual incidence of 1 to 5 per 1,000,000. To effect significant reduction in short- and long-term morbidity and mortality, and advance clinical care and research, coordination of multiple medical, surgical, behavioral, and basic scientific disciplines is required. On March 2, 2017, an investigator-driven meeting was held immediately before the American Academy of Dermatology Annual meeting for the central purpose of assembling, for the first time in the United States, clinicians and scientists from multiple disciplines involved in SJS/TEN clinical care and basic science research ...
Dr. Charles Miller uses biochemical, cellular, and animal model systems to investigate the mechanistic actions of synthetic and naturally occurring chemicals. He is investigating the major toxic compounds in crude oil as they age in the environment. He also is investigating mechanisms of chemical entry into cells. He teaches basic and advanced toxicology courses. His undergraduate training was in the life sciences at the University of Alabama in Birmingham (UAB). He was a research associate UAB and studied immunology of natural killer cells.
Report on Erowids participation in the 2006 North American Congress of Clinical Toxicology including description of medical toxicology
OSMOL GAP: CALCULATION AND APPLICATION IN CLINICAL TOXICOLOGY answers are found in the Guide to Diagnostic Tests powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
A doctor turned victim from side-effects of prescription meds after an accident. Subsequently developed leaky gut, multiple allergic responses to food and airborne substances, and home bound. Now recovered 10 years, she consults, teaches, lectures and helps others overcome chemically-induced immune system disorders.
A doctor turned victim from side-effects of prescription meds after an accident. Subsequently developed leaky gut, multiple allergic responses to food and airborne substances, and home bound. Now recovered 10 years, she consults, teaches, lectures and helps others overcome chemically-induced immune system disorders.
NMS Labs is the nations premier independent provider of laboratory testing services, specializing in clinical toxicology and other vitally important areas of esoteric diagnostics testing.
ASMCUE is shaped by attendeess. No matter your professional level, you can showcase teaching methods, share knowledge with colleagues, and contribute...
In this handy, pocket-size compilation of information about drug usage, the text is essentially in tabular form. Besides the usual tables on conversion factors, normal laboratory values, dialyzable drugs, and the potassium and sodium content of drugs and foods, this handbook provides lists of drug-induced diseases, pharmacogenetic abnormalities, and drug-drug interactions. The authors even attempt to categorize the clinical significance of the individual interactions.. A five-page course in the application of pharmaco-kinetics and biopharmaceutics to patient care is followed by information on dosage and contraindications of 190 widely used drugs. Although supplemented in a few instances with the plasma half-life, ...
This topic contains 451 study abstracts on Statin Drugs indicating they may contribute to Statin-Induced Pathologies, Myopathies, and Chemically-Induced Liver Damage
This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015 ...
Here we report further our investigation of the role of BRE in HCC. HCC was chemically-induced in the transgenic (TTR-V5-BRE) and non-transgenic littermates, bred with C57BL/6, by intraperitoneal injection of diethylnitosamine (DEN) at 15 days postnatally. At 8 months after injection, the mice were sacrificed, and livers collected for determination of tumor number and maximal size, and for immunohistochemistry. Parts of each liver sample were also dissected visually into tumor and adjacent normal portions for Western Blot analysis of BRE expression. By comparison between the DEN-treated male transgenic mice (n=12) and non-transgenic littermate controls (n=8), we observed significantly increased tumor size shown by the former (p=0.049, Exact Wilcoxon Rank Sum test), with the median tumor size 2-fold larger than the latter. There was, however, no statistically significant difference between tumor numbers of the two groups. Female C57BL/6 mice are known to be less sensitive to DEN-treated ...
Who DOES Meghan need to curtsey to? A proof in the etiquette minefield Meaning shell often have to bend the knee to Camilla and Sophie but under no circumstances to Zara NFL Corridor of Fame quarterback Warren Moon grabbed assistant at his firm through the crotch and taken off her bathing fit after slipping drug into her drink The way to rest similar to a little one in mentor class: Airplane designer reveals his hacks for finding shut-eye with a flight Disgraced Matt Lauer has no intention of wanting to come up with a Billy Bush comeback and just really wants to Perform golf and stay in the Hamptons I was suffering from chemically-induced psychosis and dementia: Fergie reveals the effects of her devastating addiction to crystal meth... as she displays on her break up from husband Josh Duhamel Disappearing act: Billionaire developer Harry Macklowe promises his real-estate holdings have SHRUNK in worth from $548.9m to just $23m as he prepares to finalize his bitter divorce from his spouse ...
Sabha, Nadeen Bassam Izzat (2015) Near and mid-infrared observations of the galactic center: on the nature of diffuse emission and faint compact sources. PhD thesis, Universität zu Köln.. Saedler, Katarzyna (2015) Role of peripheral tissue FTO in energy homeostasis and in chemically-induced hepatocarcinogenesis. [Thesis Abstract]. Saggiorato, Guglielmo (2015) How Sperm Beat and Swim: From Filament Deformation to Activity. PhD thesis, Universität zu Köln.. Sagirli, Gülay (2015) Die Einführung des Neuen Steuerungsmodells im deutschen Hochschulsystem. Erklärungsansätze für den Wandel im Management und der Verwaltung von Hochschulen. PhD thesis, Universität zu Köln.. Sahler, Sebastian (2015) Über die Wasserstoffspeichereigenschaften von Ethylendiaminbisboran und Hydrazinbisboran in Gegenwart von Ionischen Flüssigkeiten. [Thesis Abstract]. Sahler, Sebastian and Scott, Martin and Gedig, Christian and Prechtl, Martin H. G. (2015) Transfer Hydrogenation Employing Ethylene Diamine Bisborane ...
Turmeric is the most studied herb with coumarins. A study evaluated the chemopreventative effects of curcumin, the most active coumarin, on radiation- induced tumors in rat mammary glands. One control group was fed a basic diet while the other control group was fed a diet containing 1% curcumin. The control group fed curcumin had 28% reduction in tumors while 84% of the other group developed mammary tumors. Other studies also show that curcumin inhibits chemically-induced carcinogenesis of the skin, colon, and stomach. ...
OPEN SCIENTIFIC SEMINAR SERIES - Avdelningen för Klinisk Farmakologi, Institutionen för laboratoriemedicin Clinical toxicology service and research at the University of Saarland University Professor Dr Markus R Meyer,Abteilung fur Experimentelle und Klinische Pharmakologie and Toxikologie, Homburg, Deutschland
BACKGROUND: The abuse of new psychoactive substances or NPS has been dramatically increasing all around the world since the late 2000s and has become a serious public health problem. NPS are a challenge for the worldwide forensic community due to the difficulties to accurately document the cases. The N-benzylmethoxy (NBOMe) group is a new class of hallucinogenic designer drugs and has gained importance in the recent years. 25I-NBOMe (2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) is an analog of the 2C series of psychedelic phenethylamine drugs that contain an N-methoxybenzyl substituent, which significantly affects their pharmacological activities ...
ACMT members are encouraged to submit a proposal for the ACMT Pre-Meeting at the 2018 North American Congress of Clinical Toxicology (NACCT) in Chicago, IL. This symposium will be held on Thursday, October 25, 2018. The Premeeting offers a full day of content centered on a theme and requires separate enrollment from the main congress. As such, subject matter appealing to a wide audience is essential to the success of the symposium ...
Andor Labs is an independent clinical toxicology reference laboratory performing drug confirmation testing using LC-MS/MS technology. We specialize in the pain management field….
TY - JOUR. T1 - Genetically engineered mouse models for liver cancer. AU - Cho, Kyungjoo. AU - Ro, Simon Weonsang. AU - Seo, Sang Hyun. AU - Jeon, Youjin. AU - Moon, Hyuk. AU - Kim, Do Young. AU - Kim, Seung Up. PY - 2020/1. Y1 - 2020/1. N2 - Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, comprising approximately 80% of cases. Murine models of HCC, such as chemically-induced models, xenograft models, and genetically engineered mouse (GEM) models, are valuable tools to reproduce human HCC biopathology and biochemistry. These models can be used to identify potential biomarkers, evaluate potential novel therapeutic drugs in pre-clinical trials, and develop molecular target therapies. Considering molecular target therapies, a novel approach has been developed to create genetically engineered murine models for HCC, employing hydrodynamics-based ...
The chemokine CCL2, which is best known for its chemotactic functions, is expressed not only by immune cells, but also by several types of malignant and stromal cells. CCL2 has been shown to exert both pro- and anti-tumor effects. However, recent results demonstrate a main role for CCL2 in tumor progression and metastasis, suggesting that this chemokine may constitute a therapeutic target for anticancer drugs. Mammary carcinoma models, including models of implantable, transgenic, and chemically-induced tumors, were employed in the setting of Ccl2 or Ccr2 knockout mice or CCL2 neutralization with a monoclonal antibody to further investigate the role of the CCL2/CCR2 signaling axis in tumor progression and metastatic spread. In our implantable tumor models, an anti-CCL2 monoclonal antibody inhibited the growth of primary malignant lesions in a biphasic manner and reduced the number of metastases. However, in Ccl2-/- or Ccr2-/- mice developing implanted or transgenic tumors, the number of pulmonary ...
Dr. Locniskar continued studying linoleic acid, an omega-6 polyunsaturated fatty acid, and the role it seems to play in protein kinase C activation and distribution, that is essential for normal cell communication. She has shown that diets high in linoleic acid have decreased chemically-induced skin carcinogenesis when fed in the promotion stage. ...
Conscious sampling allows the teacher to assess the comparative effectiveness of his teaching methods by measuring the conscious attention of his students to what is going on in the classroom. (CK)
Stephanie H. Hernandez, Maryann Howland, Thomas D. Schiano & Robert S. Hoffman (2015): The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies, Clinical Toxicology, DOI: 10.3109/15563650.2015. ...
Writer Name NM Sharma Publication Sikhwal Publication Language Hindi Book Edition 2020-21 publication LanguagehindiTotal Pages-Book EditionLatest New Edition
Several of the pressing scientific challenges in the filed of environmental toxicology are to understand the basic mechanisms of chemically-induced toxic substances and of the design, interpretation, and extrapolation of data from non-human bioassay systems to the human situation. The objective is to offer a new paradigm, namely the idea that cytotoxic and epigenetic effects of chemicals can contribute to many toxic endpoints in human beings. We will speculate that the disruption of calcium homeostasis by a wide variety of chemicals and the conditions of their use might provide an unification of mechanisms leading to either cytotoxicity or epigenetic changes. Depending on the conditions, the effects of this disruption, a pleiotropy of diseases might result, namely, embryotoxicity, teratogenesis, tumor promotion, immune modulation, neurotoxicity, and preproductive dysfunction. In summary, there are at least three biological endpoints at the cell level which chemicals can influence - mutations, cell death
BACKGROUND: The two projects were part of a Specialized Center of Research (SCOR) in Occupational and Immunologic Lung Disease. Since its inception in 1972, researchers in the SCOR have conducted epidemiologic studies on asbestosis, silicosis in sandblasters, and respiratory reactions in workers exposed to detergent enzymes and polyvinyl chloride film fumes. Irritant gases and vapors are utilized in herbicides, pesticides, pharmaceuticals, household cleaners, explosives, fertilizers, refrigeration, plastics, paints, fumigants and a variety of other products. These chemicals are produced and used immediately or shipped to end-users. The potential for chemical accidents is great. A report for the Environmental Protection Agency estimated that 6,928 chemical accidents have occurred in the United States since 1980, an average of five accidents each day. As a result, 1,500 people were injured and 135 killed. More information was needed on the consequences of chemically-induced sublethal acute lung ...
This topic has 2 study abstracts on Centella asiatica indicating that it may have therapeutic value in the treatment of Lead Poisoning, Chemically-Induced Liver Damage, and Lipopolysaccharide-Induced Toxicity
Answer: The cited article notes Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B deficiency, hypomagnesemia, bone fractures, and rebound hyperacidity after discontinuation. (DeBruyne P and Ito S. Toxicity of long-term use of proton pump inhibitors in children. 2018 Arch Dis Child 103: 78-82). ...
Wright State University Boonshoft School of Medicine and Dayton Childrens Hospital - Cited by 3,061 - Pediatric Clinical Pharmacology - Pediatric Clinical Research - Pediatric Clinical Toxicology
Drug-induced photosensitivity may present in a variety of ways. Most reactions are either phototoxic or photoallergic. Photoallergy is a rare, immunological response, which is not dose-related and occurs after continuous exposure. Photoallergy occurs when light causes a drug to act as a hapten, triggering a hypersensitivity response which often manifests as pruritic and eczematous rash.Phototoxic reactions are chemically-induced reactions which occur when the drug absorbs UVA light and causes cellular damage. This reaction can be seen with initial exposure to a drug, may be dose-related, and doesnt demonstrate cross-sensitivity. It usually has rapid onset and manifests as an exaggerated sunburn. This reaction will be seen only on skin areas exposed to the sun ...
Background: Hepatocellular carcinoma (HCC) is a common complication of hepatitis C virus related cirrhosis (HCV-C). Alpha-fetoprotein (AFP) has been proposed as a biomarker of HCC risk. S-adenosylmethionine (SAMe) is a food supplement that has an excellent safety profile. The use of SAMe as a chemopreventive is based on abnormalities in methionine cycle (with decreased SAMe levels) in patients with cirrhosis, increased risk of HCC in experimental animals deprived of SAMe, and the prevention of liver cancer by SAMe administration in animal models of chemically-induced HCC.. Methods: This was a prospective, randomized, placebo-controlled, double-blind phase IIb trial to determine if SAMe (up to 2.4 grams/day) for 24 weeks reduced serum AFP levels in patients with HCV-C. Inclusion criteria: lab evidence of HCV-C (platelet count ,150,000/mm3), AFP 15-100 ng/mL (normal less than 9 ng/mL). Exclusion criteria: non-HCV liver diseases, decompensated HCV-C (MELD,15), or history of, or mass suspicious for ...
TY - JOUR. T1 - Editorial on exposure assessment of a mercury spill in a Nevada school - 2004. AU - Burgess, Jefferey L. PY - 2007/5. Y1 - 2007/5. UR - http://www.scopus.com/inward/record.url?scp=34248211151&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=34248211151&partnerID=8YFLogxK. U2 - 10.1080/15563650601033417. DO - 10.1080/15563650601033417. M3 - Article. C2 - 17486489. AN - SCOPUS:34248211151. VL - 45. SP - 431. JO - Clinical Toxicology. JF - Clinical Toxicology. SN - 1556-3650. IS - 4. ER - ...
Question: Listeriosis is caused by the Gram-positive organism, Listeria monocytogenes. This bacterium generally causes self limited and mild gastroenteritis. What is the disease profile often associated with Listeria monocytogenes infections in at risk populations (e.g. pregnant women, elderly people, immuno-compromised people, unborn babies, and neonates) with possible inadequate cell mediated immunity?. ...
This exemplary Handbook provides readers with a novel synthesis of international research, evidence-based practice and personal reflections to offer an overview of the current state of knowledge in the field of teaching geography in higher education. Chapters cover the three key transitions - into, through, and out of higher education - to present a thorough analysis of the topic ...
1.. Jacob J, Heard K.Second case of the use of intravenous fat emulsion therapy for propafenone toxicity. Clinical Toxicology 49: 946-947, No. 10, Dec 2011. Available from: URL: http://dx.doi.org/10.3109/15563650.2011.629202 - USA ...
Interview in todays Telegraph: His team have compiled a list of the top 100 comprehensive schools Most of them insist on streaming their pupils across the board, including the wearing of blazers and ties are in. They have long lunch...
Large-scale initiatives, such as ToxCast, promote a shift in the paradigm for regulatory evaluations of new and existing substances; specifically, away from time-consuming in vivo assays towards predictive, short-term in vitro assays. Unfortunately, the assays included in such initiatives are ill-equipped to assess chemically-induced genetic damage and mutation. Moreover, many currently used mammalian cell genotoxicity assays generate an unacceptably high frequency of false or irrelevant positive results with respect to in vivo mutagenicity and/or carcinogenicity. A novel in vitro gene mutation assay utilizing primary hepatocytes from the transgenic Muta™Mouse was been developed to address the shortfalls of existing in vitro mutagenicity assays. In order to assess the utility of the Muta™Mouse primary hepatocyte assay, the cells were extensively characterized. Freshly isolated cells were found to have a hepatocyte-like morphology, with a large proportion of binucleated cells. After 24 hours ...
Video articles in JoVE about ovarian follicle include A Method for Ovarian Follicle Encapsulation and Culture in a Proteolytically Degradable 3 Dimensional System, Methods for Imaging Intracellular pH of the Follicle Stem Cell Lineage in Live Drosophila Ovarian Tissue, Culture and Co-Culture of Mouse Ovaries and Ovarian Follicles, In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity, Studying Mitochondrial Structure and Function in Drosophila Ovaries, Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes, Three-dimensional Reconstruction of the Vascular Architecture of the Passive CLARITY-cleared Mouse Ovary, A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice, Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time, Alginate Hydrogels for Three-Dimensional Organ Culture of Ovaries and Oviducts, Orthotopic Ovarian
Hysteretic behavior of bladder afferent neurons in response to changes viagra without a doctor prescription in bladder pressure. Polyclonal increase in certain IgG subclasses in mice persistently infected with the 87V strain of scrapie.. Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats. Morphological characteristics of the mandibular first premolars in viagra without doctor prescription people from Pearl River Delta region in Guangdong province Moreover, the levels of markers of the protein-modification process were similar to those of the control group.. Their spontaneous rhythmic activity was perturbed by delivering excitatory single pulses or periodic pulses via their synaptic inputs. Deglutition disorders-simple to diagnose viagra vs cialis and difficult to treat? Of the top 33 strains most sensitive to radiation in this assay, 14 contained genes known to be involved in DNA repair.. The ratios did not correlate in a statistically ...
The purpose of this study was to establish whether curcumin protects renal proximal tubule cells against ischemic injury, determine whether this postulated cytoprotective effect is mediated through the upregulation of HSP70, and investigate whether the mechanism by which curcumin induces HSP70 expression and confers its protective effect is through activation of the Unfolded Protein Response. LLC-PK1 cells were cultured on collagen-coated filters to mimic conditions of in vivo renal proximal tubule cells and induce cell polarization. Injury with and without curcumin treatment was studied by using chemically-induced ATP-depletion which mimics renal ischemic injury. Cell injury was assessed using a TUNEL assay in order to evaluate DNA cleavage associated with ischemia-induced apoptosis and actin staining used to assess cytoskeletal disruption. Renal ischemic damage was further investigated by determining detachment of the Na-K ATPase from the basolateral membrane, which represents loss of cell polarity.
An overview of language teaching methods from the 1780s to 1980s and beyond. For teachers of English, especially as foreign language.
This pages outlines the methods of teaching, the types of assessment and examinations, lecture delivery and how this differs for research students.
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Although, teaching is the most complicated process yet learning is also an incredibly thorny procedure. The teaching method in different schools is extremely quite different ...
A report from the Thomas B. Fordham Foundation takes a swipe at the whole-language movement for promoting reading materials and teaching methods the author says are of questionable value.
... may induce panic attacks in persons with existing panic disorder; up to 72% of individuals with panic disorder ... Sodium lactate may therefore also be used to confirm a diagnosis of panic disorder.: 19 Sodium lactate is not chemically ... Despite the similarity in name, sodium lactate itself is not chemically similar to lactose (milk sugar), so need not be ... Eric Hollander; Daphne Simeon (2003). Concise Guide to Anxiety Disorders. American Psychiatric Pub. p. 1. ISBN 978-1-58562-080- ...
... chemically induced models, and electrically induced models. New models are using light-gated ion channels to turn on cell ... Sarkisian, Matthew R. (31 May 2001). "Overview of the Current Animal Models for Human Seizure and Epileptic Disorders". ...
... naturally or chemically induced) Retinal detachment Scarring of the cornea or sclera Uveitis Neurological causes for ... Related Disorders 2009 Jan;15(1):59-61. 15 (1): 59-61. doi:10.1016/j.parkreldis.2008.01.011. PMID 18328771.{{cite journal}}: ... ISBN 978-0-12-709801-2. Wakakura M, Tsubouchi T, Inouye J (March 2004). "Etizolam and benzodiazepine induced blepharospasm". J ... "Abnormal transient pupillary light reflex in individuals with autism spectrum disorders". J Autism Dev Disord. 39 (11): 1499- ...
Charcot-Marie-Tooth (CMT) is the most frequent heritable disorder of the peripheral nervous system (a neuronal disease) and is ... Diabetes, a metabolic disease, induces oxidative stress, which triggers a build up of mitochondrial tRNA mutations. It has also ... Another use is introducing amino acids bearing reactive functional groups for chemically modifying the target protein. Certain ... Mutations in the mitochondrial enzyme have been associated with a number of genetic disorders including Leigh syndrome, West ...
It has further been shown that in chemically-induced myotonia in isolated rat muscle, myotonia could be dampened by increasing ... Potassium channel disorders (KCNJ2) Andersen-Tawil syndrome Other disorders Thyroid disorders Neuromyotonia (Isaacs Syndrome) ... The disorder is caused by mutations in part of a gene (CLCN1) encoding the ClC-1 chloride channel, resulting in muscle fiber ... This may be partly because there are over 130 currently known different mutations that can cause the disorder, each with their ...
Neurotoxin models include chemically induced toxicity in the brain; whereas, genetic models include genes that are mutated and ... Parkinson's disease is a neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra ... Consequently, this will induce parkinsonian phenotypes. The α-synuclein pre-formed fibrils (PFFs) are made in vitro utilizing ... Pten-Induced Kinase 1 (PINK1) mutations are associated with autosomal recessive parkinsonism. It is a neuroprotective kinase ...
ISBN 978-0-07-142280-2. Schardein, James L. (2000). "Hormones and Hormone Antagonists". Chemically Induced Birth Defects (3rd ... ISBN 978-0-7236-7045-2. Jaffe, Robert B. (2004). "Disorders of Sexual Development". In Strauss, Jerome F.; Barbieri, Robert L ... ISBN 978-0-7216-9546-4. Forest, Maguelone G. (2006). "Diagnosis and Treatment of Disorders of Sexual Development". In DeGroot, ... Congenital disorders of female genital organs, Intersex variations). ...
In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but ... This connection also came about through the actions of the chemically active ROS, which work as one of the main components that ... Nong Y, Kandil O, Tobin EH, Rose RM, Remold HG (January 1991). "The HIV core protein p24 inhibits interferon-gamma-induced ... 2013). "Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury". PLOS ONE. ...
Like other drug-induced SCARs disorders, AGEP is a type IV hypersensitivity reaction in which a drug or its metabolite ... non-essential drugs should be discontinued and essential drugs should be replaced by chemically unrelated drugs that are used ... Severe cutaneous adverse reaction (SCAR) disorders are regarded as the drug-induced activation of T cells which then initiate ... Since a SCARs-inducing drug or metabolite interacts with only one or a few HLA serotypes, their ability to induce SCARs is ...
Any stimulus that drives the ordered ⇔ disordered phase transition can induce such actuation (or 'activation'). A patterned ... When strained, different regions of these chemically homogeneous films stretch to different extents as a result of the relative ... As a result, some small, finite stress is necessary in experimental systems to induce chain reorientation. Once the chain has ... Experimentally, a small but non-zero stress is required to induce soft elasticity and achieve this chain rotation. This ...
Some sleep disorders such as narcolepsy do require pharmacological treatment. Sleep disorder Sleep medicine Snoring Bradley DT ... Benzodiazepine causes the GABA receptor to better bind to GABA, allowing the medication to induce sleep. Generally, these ... Pharmacological treatments are used to chemically treat sleep disturbances such as insomnia or excessive daytime sleepiness. ... Sleep disorders are separated into four distinct categories: parasomnias; dyssomnias; sleep disorders associated with mental, ...
This drug was also shown to induce pain in patients with atypical facial pain. After taking the drug on empty stomach, it is ... It is also indicated for diabetic retinopathy (both treatment and prevention in people with type-2 diabetes). Chemically, it is ... Journal of Craniomandibular Disorders. 3 (4): 211-2. PMID 2639158. Wiedemann, Meike; de Lima, Vera M. Fernandes; Hanke, ...
... is chemically similar to risperidone, of which it is a structural analogue. It was first synthesized in 1987 at the ... The civil settlement also resolves allegations that Pfizer paid kickbacks to health care providers to induce them to prescribe ... 2003). "Ziprasidone-associated mania: a case series and review of the mechanism". Bipolar Disorders. 5 (1): 72-75. doi:10.1034/ ... Nicolson, SE; Nemeroff, CB (December 2007). "Ziprasidone in the treatment of mania in bipolar disorder". Neuropsychiatr Dis ...
... drugs that induce a sense of energy and alertness); and hallucinogens (drugs that induce perceptual distortions such as ... Until 1963, when it was chemically analysed by Albert Hofmann, it was completely unknown to modern science that Psilocybe ... Williams, AR (June 2020). "Cannabis as a Gateway Drug for Opioid Use Disorder". Journal of Law, Medicine & Ethics. Cambridge ... Hallucinogen-induced psychosis occurs when psychosis persists despite no longer being intoxicated with the drug. It is ...
Although electrogustometry is widely used, there seems to be a poor correlation between electrically and chemically induced ... National Institute on Deafness and Other Communication Disorders, "Taste Disorders," 25 June 2008, 23 Oct. 2009 The University ... In general, gustatory disorders are challenging to diagnose and evaluate. Because gustatory functions are tied to the sense of ... Because taste disorders can have detrimental effects on a patient's quality of life, more research needs to be conducted ...
This has made it a useful tool for chemically induced dimerization applications where it can be used to manipulate protein ... which is used in treating patients after organ transplant and patients with autoimmune disorders. Tacrolimus has been found to ... Fegan, A; White, B; Carlson, JC; Wagner, CR (Jun 9, 2010). "Chemically controlled protein assembly: techniques and applications ...
Neural chemically induced progenitor cells (ciNPCs) can be generated from mouse tail-tip fibroblasts and human urinary somatic ... Mutations can cause diabetes, deafness, eye disorders, gastrointestinal disorders, heart disease, dementia, and other ... The chemically induced cardiomyocyte-like cells (ciCMs) uniformly contracted and resembled human cardiomyocytes in their ... March 2017). "Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts". Scientific ...
She also has consulted in cases of chemically related illnesses. For her contributions in the health professions, Miller was ... She organized and chaired two National Institutes of Health meetings on chemical intolerance, and documented toxicant-induced ... Miller's research interests include "neurodevelopment and the environment (autism, attention deficit hyperactivity disorder), ... Miller, C. S. (1997). "Toxicant-induced loss of tolerance--an emerging theory of disease?". Environmental Health Perspectives. ...
Neurotoxicity is another cause of brain damage that typically refers to selective, chemically induced neuron/brain damage. Head ... from a genetic disorder, or from a congenital disorder. Unlike a broken bone where trauma to the body is obvious, head trauma ... Prognosis, or the likely progress of a disorder, depends on the nature, location, and cause of the brain damage (see Traumatic ... Narcolepsy and sleep disorders are common misdiagnoses.[citation needed] Cognitive symptoms include confusion, aggressive, ...
Freudenreich O (2007). "Treatment of psychotic disorders". Psychotic disorders. Practical Guides in Psychiatry. Lippincott ... Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been ... Schillevoort I, de Boer A, Herings RM, Roos RA, Jansen PA, Leufkens HG (July 2001). "Antipsychotic-induced extrapyramidal ... Perphenazine is used to treat psychosis (e.g. in people with schizophrenia and the manic phases of bipolar disorder). ...
Some blood and hepatic disorders have also been seen in a small number of patients. Pyrimethamine is used in the treatment of ... Mefloquine was developed during the Vietnam War and is chemically related to quinine. It was developed to protect American ... with the drug inducing vomiting and esophagitis. It was not recommended for use during the first trimester, although considered ... It is a phenanthrene methanol, chemically related to Quinine and acts acting as a blood schizonticide effective against all ...
... including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychosis. In a 2013 comparison ... chemically, is one of the phenothiazines. Its mechanism of action is not entirely clear but believed to be related to its ... It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, ... This assumption arose from the dopamine hypothesis that maintains that both schizophrenia and bipolar disorder are a result of ...
... drug-induced nasal congestion), reduced seizure threshold, tics (a type of movement disorder), and weight loss. Dangerous ... As a member of the phenethylamine class, amphetamine is also chemically related to the naturally occurring trace amine ... Substance-use disorder: A diagnostic term in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders ( ... Amphetamine is used to treat attention deficit hyperactivity disorder (ADHD), narcolepsy (a sleep disorder), and obesity, and ...
... alone and in combination with carbidopa has been studied in the treatment of attention deficit hyperactivity disorder ... or hemodialysis-induced hypotension. Freezing of gait in Parkinson's disease (off-label) With over 20 years on the market, ... is chemically analogous to levodopa (L-3,4-dihydroxyphenylalanine; L-DOPA). Whereas levodopa functions as a precursor and ... and NOH associated with various disorders such as MSA, FAP, and PD, as well as IDH. The drug has been used in Japan and some ...
... as well as chemically induced mutants developed by Fleming researchers. The Animal House has a capacity to house more than ... Fields of excellence: Molecular mechanisms of disease (inflammation, cancer, metabolic syndrome, CNS disorders) Biomedical ...
What had been shown was that they were potent inhibitors of ADP-induced platelet aggregation, but the P2Y12 receptor had not ... It became more urgent to find a new analog after reports of patients having severe hematological disorders due to ticlopidine. ... that they affect platelets irreversibly because of their long duration of action and the active metabolite was chemically and ... Cangrelor has a 78% mean recovery of ADP induced platelet aggregation in rat after 20 minutes comparison to compound 1C which ...
The relationships between these different chemical systems are complex as some of them suppress and some of them induce each ... Clark, L.A., Watson, D., & Mineka, S. (1994). Temperament, personality, and mood and anxiety disorders. Journal of Abnormal ... as neuro-chemically-based individual differences) and mental illness represents varying degrees along the same continuum of ... Medications can adjust the release of brain neurotransmitters in cases of depression, anxiety disorder, schizophrenia and other ...
... and chemically isolated by the blood-brain barrier, they are very susceptible if compromised. Nerves tend to lie deep under the ... has been reported to induce neurological problems, at least in the case of lead. The neurological problem may start in another ... A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain ... The broadest division is between central nervous system disorders and peripheral nervous system disorders. The Merck Manual ...
... (chemically it is 19-nor-1,25-(OH)2-vitamin D2. Marketed by Abbott Laboratories under the trade name Zemplar) is a ... Thiazide diuretics or calcium supplements as hypercalcaemia may be induced by this combination Magnesium-containing products ... of breath Nose bleed Cough Rectal haemhorrhage Colitis Gastritis Indigestion Difficulty swallowing Gastrointestinal disorder ... Coma Stroke Transient ischemic attack Fainting Myoclonus Hypoaesthesia Paraesthesia Glaucoma Conjunctivitis Ear disorder ...
... and most recently the systems neuroscience of autism spectrum disorder (ASD) and related neurodevelopmental disorders.[ ... Specifically, Silva and his colleagues showed that neural progenitor stem cells could be induced to differentiate into neurons ... and the optimization of chemically functionalized quantum dots to achieve high resolution imaging of cellular structure and ... A related goal is understanding what changes in these processes in autism spectrum disorder and related neurodevelopmental ...
Vibration moves the plates, causing the capacitance to vary, in turn inducing AC current. Some dielectrics also generate ... P. (2006). Fractals, diffusion and relaxation in disordered complex systems. Part A. Wiley. p. 17. ISBN 0-470-04607-4. 2005 ... Examples of dielectric media are glass, air, paper, plastic, ceramic, and even a semiconductor depletion region chemically ... thus an opposite polarity charge will be induced on the surface of the other conductor. The conductors thus hold equal and ...
Cannabis use disorder is defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as ... This tar is chemically similar to that found in tobacco smoke or cigars. Over fifty known carcinogens have been identified in ... A 2019 meta-analysis found that 34% of people with cannabis-induced psychosis transitioned to schizophrenia. This was found to ... Cannabis use disorder is defined as a medical diagnosis in the fifth revision of the Diagnostic and Statistical Manual of ...
Vecchio, Cesare; Frisinghelli, Anna (2008). "Topically Applied Heparins for the Treatment of Vascular Disorders: A ... Heparinoids are glycosaminoglycans which are chemically and pharmacologically related to heparin. They include oligosaccharides ... is a recombinant preparation of the polypeptide anticoagulant secreted by leeches and is used in patients with heparin induced ...
Citalopram-induced macropsia is similar to zolpidem-induced macropsia since both types have been observed in relatively few ... Symptoms caused chemically by drugs such as cannabis, magic mushrooms, or cocaine tend to dissipate after the chemical compound ... Children who experience nocturnal hallucinations accompanied by macropsia may seek medical care for panic attack disorders and ... With regard to drug-induced or virus-induced macropsia, once the underlying problem, either drug abuse or viral infection, is ...
During the detection of diatomic gases, the binding of the gas ligand to the heme iron induces conformational changes in the ... Defects in various enzymes in synthesis of heme can lead to group of disorder called porphyrias, these include acute ... as all the intermediates are tetrapyrroles that are chemically classified as porphyrins. The process is highly conserved across ... Ohshima, H. (2003). "Chemical basis of inflammation-induced carcinogenesis". Arch. Biochem. Biophys. 417 (1): 3-11. doi:10.1016 ...
... and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 ... HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It ... "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder". Human ... proline to leucine missense mutation within the first RLD domain has been implicated in a neurodevelopmental disorder with ...
The chirality induces a finite azimuthal twist from one layer to the next, producing a spiral twisting of the molecular axis ... The next step to commercialization of liquid-crystal displays was the synthesis of further chemically stable substances ( ... with the material being essentially disordered in the other two directions. Thermotropic phases are those that occur in a ... Both electric and magnetic fields can be used to induce these changes. The magnitude of the fields, as well as the speed at ...
... which indicates that PGLYRP3 protects mice from DSS-induced colitis. The anti-inflammatory effect of PGLYRP3 on DSS-induced ... May 2005). "Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition ... August 2014). "Peptidoglycan recognition protein genes and risk of Parkinson's disease". Movement Disorders. 29 (9): 1171-80. ... PGLYRP3-induced killing involves simultaneous induction of three stress responses in both Gram-positive and Gram-negative ...
Both physical and chemical properties of plasma are known to induce uptake of nanomaterials in cells. For example, the uptake ... The plasma sources used for plasma medicine are generally low temperature plasmas, and they generate ions, chemically reactive ... The Skin Center Dermatology Group (2020-03-25). "Using a Cold Atmospheric Plasma Device to Treat Skin Disorders". {{cite ... "Singlet-Oxygen-Induced Phospholipase A2 Inhibition: A Major Role for Interfacial Tryptophan Dioxidation". Wiley. Retrieved 2021 ...
It is generally believed the high voltage activation step induces various cation defects that on cycling equilibrate through ... "Complex Nanomaterials in Catalysis for Chemically Significant Applications: From Synthesis and Hydrocarbon Processing to ... Institute of Technology found that creating high lithium content lithium-ion batteries materials with cation disorder among the ...
By inducing upregulation of methyltransferase inhibitors, the effects of the loss-of-function mutation can be mitigated. ... Antagomirs are single strand RNAs that are complementary, which have been chemically engineered oligonucleotides that silence ... HDACi's have been used in various Autoimmune Disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and ... Cells that carry loss-of-function mutations can be targeted by drugs that induce synthetic lethality, a genetic/protein ...
Acoustics: Stephan Reber, Takeshi Nishimura, Judith Janisch, Mark Robertson, and Tecumseh Fitch, for inducing a female Chinese ... for chemically analyzing the air inside movie theaters, to test whether the odours produced by an audience reliably indicate ... Journal of Affective Disorders. 217: 289-294. doi:10.1016/j.jad.2017.04.017. ISSN 0165-0327. PMID 28441620. Eren, Metin I.; ... Shafik, Ahmed (May 1992). "Contraceptive efficacy of polyester-induced azoospermia in normal men". Contraception. 45 (5): 439- ...
McGuire JF, Lewin AB, Storch EA (August 2014). "Enhancing exposure therapy for anxiety disorders, obsessive-compulsive disorder ... In 1914, two scientific papers claimed quebrachine was chemically identical to yohimbine. This was disputed, and the matter ... Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries ... Yohimbine has been studied as a way to improve the effects of exposure therapy in people with post traumatic stress disorder ( ...
... by inducing the phosphorylation of GLUT4 enhancer factor), decreases insulin-induced suppression of fatty acid oxidation, and ... Cochrane Metabolic and Endocrine Disorders Group) (December 2019). "Metformin for prevention or delay of type 2 diabetes ... and metformin are chemically synthesized compounds composed of two guanidine molecules, and are more lipophilic than the plant- ... Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice, and this may contribute to ...
... ing can be induced by electric scalp stimulation, study finds Archived 2021-03-20 at the Wayback Machine "A look at ... Hobson, J. Allan (2001). The Dream Drugstore: Chemically Altered States of Consciousness. Cambridge, Massachusetts: MIT Press. ... A Therapeutic Intervention in Patients with Nightmares and Post-Traumatic Stress Disorder. 21st Congress of the European Sleep ... Studies have shown that, by inducing a lucid dream, recurrent nightmares can be alleviated. It is unclear whether this ...
Chemically inhibiting the PI3K pathway in PDGF-stimulated cells negates the differential effect between the two growth factors ... Over-expression of PDGF has been linked to several diseases such as atherosclerosis, fibrotic disorders and malignancies. ... "12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of ...
In addition to being chemically complex, natural birnessite crystals are structurally disordered with respect to the layer ... 2008). "Defect-Induced Photoconductivity in Layered Manganese Oxides: A Density Functional Theory Study". Physical Review ... The stacking disorder is referred to as "turbostratic" when the layers are oriented completely at random. Natural birnessite ...
Ionizing irradiation can induces a highly complex form of DNA damage as clustered damage. It consists of different types of DNA ... Cells are known to eliminate three types of damage to their DNA by chemically reversing it. These mechanisms do not require a ... Other DNA repair disorders include: Werner's syndrome: premature aging and retarded growth Bloom's syndrome: sunlight ... Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after ...
Dosages above approximately 300 mg/day risk inducing tardive dyskinesia. However, given the drug's fairly wide window of ... It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, ... A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride ... could underlie its particular efficacy in treating these affective disorders. Moreover, its selectivity for the dopaminergic ...
Opioids will bind to the receptor for the endorphin they are most chemically similar to. Tolerance to some effects occurs with ... Jain R. and S.G. Holtzmann (2005). "Caffeine Induces Differential Cross Tolerance to the Amphetamine-like Discriminative ... such as carbamazepine and lamotrigine are also used for mood disorders. This would demonstrate little to zero cross-tolerance ...
Disorders of the prostate include enlargement, inflammation, infection, and cancer. The word prostate comes from Ancient Greek ... Levin, R. J. (2018). "Prostate-induced orgasms: A concise review illustrated with a highly relevant case study". Clinical ... It differs between species anatomically, chemically, and physiologically. Anatomically, the prostate is found below the bladder ...
... hallucinogen persisting perception disorder, schizoaffective disorder, and borderline personality disorder. It has not been ... Lamotrigine can induce a type of seizure known as a myoclonic jerk, which tends to happen soon after the use of the medication ... Lamotrigine is a phenyltriazine, making it chemically different from other anticonvulsants. Its mechanism of action is not ... In bipolar disorder, lamotrigine has not been shown to reliably treat acute depression; but for patients with bipolar disorder ...
... induced Hair dye-induced Hair lotion-induced Hair spray-induced Hair straightener-induced Hair tonic-induced Houseplant-induced ... Skin Disorders at Curlie All the Internet - Directory - Main/Health/Conditions_and_Diseases/Skin_Disorders Archived 18 June ... In the embryo, the epidermis, hair, and glands form from the ectoderm, which is chemically influenced by the underlying ... Drug-induced lupus erythematosus Drug-induced nail changes Drug-induced pigmentation Drug-induced pseudolymphoma Drug-induced ...
It is also possible to fuse a protein constructed in this way with the catalytic domain of an endonuclease in order to induce a ... Chemically combined, synthetic single-stranded DNA (ssDNA) and a pool of oligionucleotides are introduced at targeted areas of ... Im W, Moon J, Kim M (September 2016). "Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders". Journal ... In Zea mays, disruption of the target locus was achieved by ZFN-induced DSBs and the resulting NHEJ. ZFN was also used to drive ...
Chemically, they behave mostly as nonmetals. They can form alloys with metals. Most of their other physical properties and ... 139-44 Taniguchi M, Suga S, Seki M, Sakamoto H, Kanzaki H, Akahama Y, Endo S, Terada S & Narita S 1984, 'Core-Exciton Induced ... Disorder in Condensed Matter Physics: A Volume in Honour of Roger Elliott, Clarendon Press, Oxford, ISBN 0-19-853938-X, pp. ... Chemically, they mostly behave as (weak) nonmetals, have intermediate ionization energies and electronegativity values, and ...
Once the prion is transmitted, the defective proteins invade the brain and induce other prion protein molecules to misfold in a ... "Creutzfeldt-Jakob Disease Fact Sheet , National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved ... Thermal depolymerization also destroys prions in infected organic and inorganic matter, since the process chemically attacks ... The Real-Time Quaking-Induced Conversion (RT-QuIC) assay has a diagnostic sensitivity of more than 80% and a specificity ...
"Chemically-Induced Disorders". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0-9 ...
Cerebrovascular Disorders / chemically induced * Cerebrovascular Disorders / complications* * Cerebrovascular Disorders / ...
Chemically-Induced Disorders [‎1]‎. Child Health [‎4]‎. Child Mortality [‎2]‎. Child Nutrition Sciences [‎1]‎. ...
Acidosis / chemically induced* * Alcohol-Induced Disorders / drug therapy * Diazepam / therapeutic use * Humans ...
Substance-Related Disorders. Chemically-Induced Disorders. Mental Disorders. To Top. *For Patients and Families ... Successful outcomes with low-threshold intervention for cannabis use disorders in Norway - an observational study. PLoS One. ...
Tobacco Use Disorder. Substance-Related Disorders. Chemically-Induced Disorders. Mental Disorders. To Top ... Clinically relevant medical or psychiatric disorder, in the opinion of the Investigator. ...
Chemically unrelated to other drugs used to treat seizure disorders. Although the mechanism of action is not clearly ... Hemiballism-hemichorea induced by subcortical ischemia. Can J Neurol Sci. 1993 Nov. 20(4):324-8. [QxMD MEDLINE Link]. ... Generalized chorea induced by nonketotic hyperglycemia. Mov Disord. 1993. 8(1):119-20. [QxMD MEDLINE Link]. ... Study of movement disorders and brain iron by MR. Am J Neuroradiol. 1987. 8:397-411. ...
Chemically-induced neuroinflammation and "sickness behavior" disorders. Authors. OCallaghan JP Source. Toxicologist 2017 Mar; ... Effect of diet-induced obesity on silica-induced pulmonary toxicity in rats. ...
A high incidence of gynecological disorders and excess frequency of spontaneous abortions have been reported in chemically ... Do not induce emesis.. Gastric lavage is useful in certain circumstances to remove caustic material and prepare for endoscopic ... Aniline induces the production of methemoglobin in both adults and children. The fetal liver can also N-oxygenate aniline to ... In cases of ingestion, do not induce emesis. If the victim is alert and asymptomatic, administer a slurry of activated charcoal ...
4] Epidemic outbreaks of chemically induced systemic fibrosing disorders such as EMS offer insights into the pathogenesis of ... Chemical exposure-induced systemic fibrosing disorders: Novel insights into systemic sclerosis etiology and pathogenesis. Semin ... Drug-induced eosinophilia may be devastating, with manifestations including the EMS; prediction models of drug-induced ... Prediction of drug-induced eosinophilia adverse effect by using SVM and naïve Bayesian approaches. Med Biol Eng Comput. 2015 ...
Duty To Warn Mercury, Aluminum and Vaccine-induced Encephalopathy (Including Autism Spectrum Disorder, ADHD, Learning Disorders ... Including Autism Spectrum Disorder, ADHD, Learning Disorders, Epilepsy, Autoimmune Disorders, Chronic Fatigue Disorder, and ... Drug-Induced Iatrogenic Disorders - The Third Leading Cause Of Death In The US And Britain. Duty to Warn Drug-Induced ... Duty To Warn: Mercury, Aluminum And Vaccine-Induced Encephalopathy. Duty To Warn Mercury, Aluminum and Vaccine-induced ...
The first milk induced a severe gastro-intestinal disorder which disappeared when a second milk was used. A third milk caused a ... The only common allergen was coconut, which was physico-chemically modified in the second milk. Demonstration of the ...
Victims with chemically-induced acute disorders may suffer from anxiety, especially children who may be separated from a parent ... In cases of ingestion, do not induce emesis. Aggressive decontamination with gastric lavage is recommended within 1 hour of ... In cases of ingestion, do not induce emesis. Aggressive decontamination with gastric lavage is recommended within 1 hour of ... In cases of ingestion, do not induce emesis. Aggressive decontamination with gastric lavage is recommended within 1 hour of ...
In addition to losing all of my behavioral disorders and literally waking up from the chemically induced walking comatic state ... The behavioral disorders that are caused by these beverages and the EDTA in them is the type of behavior that we all witnessed ... My CNN iReport articles are centered around the fact that I stopped a 44 year old bipolar manic disorder without the help of ...
... a metabolic disorder which affects a persons ability to detoxify certain groups of chemicals. ... This suggests that they may be the result of an acquired abnormality, due either to the direct effects of a chemically-induced ... Grace Ziem and Albert Donnay to assist doctors in evaluating disorders of porphyrin metabolism in chemically-injured patients. ... they offer no information on chemically-acquired disorders of porphyrin metabolism or porphyrinuria. ...
Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot- ... Persistent sleep problems among people in recovery from substance use disorders: a mixed methods study  Erga, Aleksander Hagen ... Improving the Methodology for Assessing Cognitive Impairment in People with Schizophrenia Spectrum Disorders  Raudeberg, Rune ... Norms matter: U.S. normative data under-estimate cognitive deficits in Norwegians with schizophrenia spectrum disorders  ...
Alcohol-Induced Disorders, Nervous System [C10.720.112]. *Alcoholic Neuropathy [C10.720.112.400]. *Chemically-Induced Disorders ... The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. ... Alcohol-Related Disorders [C25.775.100]. *Alcohol-Induced Disorders [C25.775.100.087]. *Alcohol-Induced Disorders, Nervous ...
Bipolar affective disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness. This ... of all patients with substance use-induced psychosis converted to either schizophrenia or bipolar disorder. Cannabis-induced ... For example, investigators have demonstrated that 2 chemically unrelated drugs (lithium and valproate) used to treat bipolar ... What is bipolar disorder? Bipolar disorder, sometimes known as manic depression, is a type of mental disorder where people ...
... two ways occurs because of behaviors that have immediate reinforcing effects despite eventually inducing serious disorders. ... Patients are told they have a malfunction in their brain that needs to be corrected chemically by ingesting a pill, which the ... Much the same can be said for bipolar disorder, formerly known as manic-depressive disorder, in that mania, the primary ... A wide array of mental disorders, such as schizophrenia, depression, anxiety, obsessive-compulsive disorder, as well as ...
Chemically Induced Disorders [C25] Chemically Induced Disorders * Poisoning [C25.723] Poisoning * Foodborne Diseases [C25.723. ... CI chemically induced. CL classification. CN congenital. CO complications. DG diagnostic imaging. DH diet therapy. DI diagnosis ...
Vision disorders. General subdivision. chemically induced.. 942 ## - ADDED ENTRY ELEMENTS (KOHA). Source of classification or ...
Chemically-Induced Disorders [C25] Chemically-Induced Disorders * Poisoning [C25.723] Poisoning * Arsenic Poisoning [C25.723. ...
... chemically-based house store medications given for bipolar disorder. This occurs when a portion of only chromosome is ... These studies revealed that patterns of gene dysregulation induced by means of tobacco smoke are hugely dose sensitive, with ... Disorders With Decreased Pulmonary Blood Rush Defects involving decreased pulmonary blood gurgle occur when there is some ... This each started virtually 20 period past medications bipolar disorder. Because generally 186,000 children and adolescents ...
C25 - Chemically-Induced Disorders. Drug Toxicity. Drug-Related Side Effects and Adverse Reactions. ... Fetal Alcohol Spectrum Disorders. C17 - Skin and Connective Tissue Diseases. Epidermal Necrolysis, Toxic. Stevens-Johnson ...
Chemically-Induced Disorders. Anticholinergic Syndrome. Síndrome Anticolinérgica. Síndrome Anticolinérgico. Chemically-Induced ... F03 - Mental Disorders. Delusional Parasitosis. Delírio de Parasitose. Delirio de Parasitosis. F04 - Behavioral Disciplines and ... Intrinsically Disordered Proteins. Proteínas Intrinsicamente Desordenadas. Proteínas Intrínsecamente Desordenadas. MEF2 ... Fetal Alcohol Spectrum Disorders. Transtornos do Espectro Alcoólico Fetal. Trastornos del Espectro Alcohólico Fetal. ...
  • Evidence for mechanistic specificity driving pulmonary particulate exposure-induced cardiovascular dysfunction. (cdc.gov)
  • Off-label therapy sometimes helpful in reducing choreiform movements and ameliorating disruptive behavior (eg, behavior induced by anger) in patients with HD. (medscape.com)
  • Chemically-induced neuroinflammation and "sickness behavior" disorders. (cdc.gov)
  • Mice with IBD induced by dextran sulfate sodium (DSS) in drinking water exhibit depressive-like behavior. (biomedcentral.com)
  • Therefore, we examined whether Enterococcus faecalis 2001 (EF-2001), a biogenic lactic acid bacterium, prevents DSS-induced depressive-like behavior and changes in peripheral symptoms. (biomedcentral.com)
  • Treatment with 1.5% DSS for 7 days induced IBD-like pathology and depressive-like behavior, increased TNF-α and IL-6 expression in the rectum and hippocampus, activated caspase-3 in the hippocampus, and decreased hippocampal neurogenesis. (biomedcentral.com)
  • In addition, by chemically blocking stress hormone receptors on neurons, we prevented stress from causing increased drinking behavior. (medindia.net)
  • Although bipolar disorder is diagnosed based on the patient's history and clinical course, laboratory studies may be necessary to rule out other potential causes of the patient's signs and symptoms as well as to have baseline results before administering certain medications. (medscape.com)
  • Pharmacovigilance of drug-induced rare diseases such as EMS are being monitored by the French Network of Regional Pharmacovigilance Centers. (medscape.com)
  • The term porphyrinuria (pour-'frin-ur-E-a) is used to categorize disorders of porphyrin metabolism and excretion that are acquired from diseases, drugs or chemicals with or without inherited enzyme abnormalities. (ei-resource.org)
  • In the Time 6 blog , I briefly mentioned methylene blue as part of a bio hack for people with neuro-degeneration and various types of traumatic brain injury like concussion, photosensitive seizures, autoimmune brain diseases, migraine headaches and exercise induces changes in neuro-cognition. (jackkruse.com)
  • Both sarcopenia and osteoporosis are geriatric diseases that decrease activity in daily living, and are interconnected physically and chemically. (researchsquare.com)
  • It has been used as single drug formulations for diseases involving vitiated blood and other bleeding disorders. (planetayurveda.com)
  • Diseases and disorders can be associated with misspellings or genetic mutations. (bvsalud.org)
  • Noncommunicable diseases (NCDs) are chronic disorders caused by non-infectious agents. (who.int)
  • What kinds of symptoms are seen in Disorders of Porphyrin Metabolism? (ei-resource.org)
  • Introduction: Remission from major depressive disorder (MDD) is associated with residual symptoms related to reduced functioning, quality of life, and relapse risk. (uib.no)
  • Post-traumatic stress disorder (PTSD) is defined as protracted symptoms associated with a traumatic situation or experience. (pbinstitute.com)
  • Rabeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward passage of acid from the stomach induces heartburn and possible damage to the esophagus. (visionpharmapk.com)
  • Drug-induced erectile dysfunction (ed) cytotec reçetesiz alınır mı is a common and underreported problem within the general population. (egocyte.net)
  • Decoration of the graphene structure with hydroxyl and epoxy groups, to form chemically derived graphene oxide (GO) and reduced graphene oxide (r-GO) in a controllable oxidation and reduction step 12 , favors large-volume synthesis and chemical solubility in a variety of solvents. (nature.com)
  • Effect of diet-induced obesity on silica-induced pulmonary toxicity in rats. (cdc.gov)
  • Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks? (uib.no)
  • A double exposure to social defeat induces sub-chronic effects on sleep and open field dehaviour in rats. (uib.no)
  • This correction prevented the blunted alcohol-induced dopamine signal, causing the stressed rats to consume less alcohol. (medindia.net)
  • Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. (researchgate.net)
  • Aniline induces methemoglobinemia, which impairs the delivery of oxygen to tissues. (cdc.gov)
  • a higher percentage than this can be genetic or caused by exposure to various chemicals and depending on the level can cause health problems known as methemoglobinemia Methemoglobinemia or Met h-b is a rare blood disorder that may be caused by an inherited or congenital condition, exposure to toxins, especially nitrates, or dehydration, particularly in infants . (ordini-veluk.com)
  • A common category with the greatest number of injuries is traumatic brain injury (TBI) following physical trauma or head injury from an outside source, and the term acquired brain injury (ABI) is used in appropriate circles to differentiate brain injuries occurring after birth from injury due to a disorder or congenital malady. (top10best.io)
  • Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. (researchgate.net)
  • For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. (visionpharmapk.com)
  • Better understanding the brain chemistry involved in stress and increased alcohol consumption could have implications for getting to the root of such disorders as post-traumatic stress disorder (PTSD). (medindia.net)
  • The troops who experienced a traumatic brain injury in bomb blasts were twice as likely to develop post-traumatic stress disorder. (medindia.net)
  • Patients suffering from post traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) experience a lower quality of life, revealed a new research. (medindia.net)
  • Military members who visited a primary care clinic while suffering from post-traumatic stress disorder and depression reported better mental health functioning. (medindia.net)
  • Psychedelic drugs have been receiving a lot of attention lately as they might be useful in treating addiction, depression, anxiety, and post traumatic stress disorder. (zmescience.com)
  • PTSD and addiction are both complex and chronic problems, but what exactly is it about post-traumatic stress disorder that makes those living with it more susceptible to using and eventually abusing drugs or alcohol? (pbinstitute.com)
  • A team led by John Dani, PhD, chair of the department of Neuroscience in the Perelman School of Medicine at the University of Pennsylvania, found that rodents that had been exposed to stress had a weakened alcohol-induced dopamine response and voluntarily drank more alcohol compared to controls. (medindia.net)
  • New research might help, as we've identified a substance that can revert stress-induced behavioral deficits and restore neural circuits affected by stress in the brain - in mice, so far. (zmescience.com)
  • Repeated DSS cycling in combination with treatment with azoxymethane, a genotoxic agent, induced colitis-dependent neoplasia, generating a commonly used model for colorectal neoplasia and cancer in humans [ 10 ]. (biomedcentral.com)
  • Butterbur leaves attenuate memory impairment and neuronal cell damage in amyloid beta-induced Alzheimer's disease models. (greenmedinfo.com)
  • Objectives Auditory verbal hallucinations (AVHs) occur as a symptom in various mental disorders, and show different phenomenological aspects, depending on their underlying psychopathology. (uib.no)
  • and a behavioral learning theory, offering treatments designed to eliminate the behaviors that characterize the mental disorders. (dissidentvoice.org)
  • Psychoanalytic theory views mental disorder as the outcome of unconsciously determined symbolic efforts that only partially resolve these intrapsychic conflicts, resulting in pathological adjustments to the vicissitudes of psychosexual development. (dissidentvoice.org)
  • Bipolar disorder, which in the ICD-10 is classified as bipolar disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness. (medscape.com)
  • Prairie Ridge also offers treatment services for people coping with gambling addiction, a sometimes co-occurring mental health disorder with drug and alcohol addiction. (nationaltasc.org)
  • The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. (umassmed.edu)
  • Instead, people turn to the temporary relief that drugs and alcohol can provide, numbing feelings of anxiety or hypervigilance, inducing sleep, and disconnecting from negative memories. (pbinstitute.com)
  • This is in part because your body and brain become chemically dependent on drugs or alcohol. (pbinstitute.com)
  • Some chemically-injured patients with Multiple Chemical Sensitivity (MCS) show disturbances in their body's system for making heme, which is the primary component of hemoglobin in red blood cells. (ei-resource.org)
  • A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. (uib.no)
  • The compound has not yet been tested on humans, so we can't be sure, but it doesn't induce head-twitching behaviors in mice after administration, as known hallucinogens do. (zmescience.com)
  • When the emotional transitions manifest more drastically as anxiety, depression, and suicidal ideation, you likely have PMDD, a severe mood disorder that arises in the one to two weeks prior to menstruation. (amaliah.com)
  • In fact, more than 50 percent of those who seek treatment for a substance abuse disorder meet the criteria for PTSD. (pbinstitute.com)
  • Opioid-Induced Hyperalgesia: Is It Really Chronic Pain? (hvrc.com)
  • This compound, which is chemically known as n-pentyl-4-hydroxybenzyl-3,4-dihydro-2h-1,4-benzoxazin-3-one hydrochloride, or nolvadex (brand name: wellbutrin xr) is used to treat narcolepsy, chronic sleep disorder, obesity, and other conditions. (egocyte.net)
  • When both are affected, cell signaling is unyoked and can lead to autoimmune, metabolic, and cell growth disorders that all have elevated ubiquitin marking associated with them. (jackkruse.com)
  • Frequent causes include nerve-damaging injury, tissue inflammation, autoimmune disorder-and use of opioid medications. (hvrc.com)
  • for the management of autoimmune and temporomandibular joint disorders. (bvsalud.org)
  • Since most heme is made in the bone marrow, these 'disorders of porphyrin metabolism' are usually found there or in the liver. (ei-resource.org)
  • Osteoporosis is defined as a skeletal disorder characterized by compromised bone strength leading to an increased risk of fracture [3]. (researchsquare.com)
  • These PTH fragments, which increase in serum as CKD progresses, could potentially modulate the effects of PTH 1-84 and contribute to CKD-associated bone disorders. (cdc.gov)
  • Optimal substitution by levothyroxine (LT4) restores biochemical euthyroidism.In postmenopausal women and elderly patients with hypothyroidism and associated vascularcomorbidity, excessive LT4 substitution could lead to atrial rhythm disorders and osteoporosis. (ac.rs)
  • Coupled with personal motivation, recovery from substance use disorders (SUD) requires engagement in accessible and supportive activity. (twintowntreatmentcenters.com)
  • TBG is chemically and biochemically similar to Ibogaine, but seems to lack its toxic and hallucinogenic effects in mice. (zmescience.com)
  • That study (cited 66 times) demonstrated that by regularly injecting mice with the neurotransmitter a large proportion of α cells would convert to β cells in wildtype animals or those chemically induced to have diabetes. (the-scientist.com)
  • Cannabis also contains other compounds that are chemically related to THC. (medicalnewstoday.com)
  • Biotransformation of organic compounds by using microbial whole cells provides an efficient approach to obtain novel analogues which are often difficult to synthesize chemically. (biomedcentral.com)
  • Premenstrual dysphoric disorder (PMDD) is a very severe form of premenstrual syndrome (PMS). (amaliah.com)
  • Opioid-induced hyperalgesia is different from addiction to or tolerance of a drug. (hvrc.com)
  • The well-ordered chemical environments induced by nitrogen dopant are revealed by XANES and RIXS measurements. (nature.com)
  • Bipolar disorder is characterized by periods of deep, prolonged, and profound depression that alternate with periods of an excessively elevated or irritable mood known as mania. (medscape.com)
  • The treatment of bipolar disorder is directly related to the phase of the episode (ie, depression or mania) and the severity of that phase, and it may involve a combination of psychotherapy and medication. (medscape.com)
  • Therefore, cytokine-induced disruption of neurogenesis might be a key link between inflammation and depression. (biomedcentral.com)
  • Disorders related to substance use or abuse. (bvsalud.org)
  • The presence of Lactobacillus in the gut microbiota is associated with major depressive disorder. (biomedcentral.com)
  • This suggests that they may be the result of an acquired abnormality, due either to the direct effects of a chemically-induced porphyrinopathy or the secondary effects of some other disease. (ei-resource.org)
  • Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease. (nel.edu)
  • Masopust J, Urban A, Valis M, Malý R, Tůma I, Hosák L. Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease. (nel.edu)
  • however, immunocompromised immunocompromised A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation. (lecturio.com)
  • If IG needs to be administered because of imminent exposure to disease, live virus vaccines may be administered simultaneously with IG recognizing that vaccine-induced immunity may be compromised. (cdc.gov)
  • Burns fat, and muscle their sexual performance, Maxtreme Pharma Sustanon experts radicular Lumbosacral psychological side effects (prednisolone (prednisolone tablets) tablets) tablets) Geneza Pharmaceuticals Hgh is primarily used for its potent anti-inflammatory effects in disorders of many organ systems. (lotusseedsdesign.com)
  • To reverse the negative effects of the erroneous excitatory signal, the team chemically prevented the excitatory switch within the reward circuitry. (medindia.net)
  • Chemically unrelated to other drugs used to treat seizure disorders. (medscape.com)
  • Q.86 Which of the following drugs does NOT induce mydriasis? (pharmatutor.org)
  • Background Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) typically experience poorer attentional control. (uib.no)
  • In general, brain damage refers to significant, undiscriminating trauma-induced damage, while neurotoxicity typically refers to selective, chemically induced neuron damage. (top10best.io)
  • Association of arterial hypertension and cognitive impairment in euthymic bipolar disorder. (nel.edu)
  • Cognitive impairment in euthymic phase of bipolar disorder has been documented in many studies. (nel.edu)
  • He was diagnosed with Early Onset Bipolar Disorder and ADHD. (followingvaccinations.com)
  • The removal/substitution of carbon atoms, topological defects/vacancies, structural disorder, molecular absorption and symmetry breaking have been demonstrated to result in the formation of localized states and electron/hole states in the electronic structures of GO and r-GO 13 , 14 . (nature.com)
  • Molecular dynamics simulations of stretch-induced crystallization in layered polyethylene ( Nikolaos Romanos, Grigorios Megariotis, Doros N. Theodorou ), In Polym. (grnet.gr)
  • Subclinical(SCH) and clinical (CH) hypothyroidism influences target organs by changing their morphology andfunction and impaired blood and oxygen supply induced by accelerated atherosclerosis. (ac.rs)
  • It is also beneficial in disorders characterized by excessive stomach acid production, such as Zollinger-Ellison syndrome. (visionpharmapk.com)
  • Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. (rxdrugnews.com)
  • Intensive Outpatient treatment for adult & adolescent substance use disorders/addictions. (twintowntreatmentcenters.com)
  • Certified by the State of California Department of Health Care Services for SUD and MediCal services, and accredited by The Joint Commission for over twenty-five years, Twin Town has earned the reputation of providing high-quality substance use disorder outpatient treatment for the broadest population. (twintowntreatmentcenters.com)
  • Using repeated intramuscular injection of nerve growth factor to induce the development of sustained muscle pain (lasting weeks), 30 healthy individuals were randomized to receive 5 consecutive daily treatments of active or sham left DLPFC rTMS, starting before the first nerve growth factor injection on day 0. (northumbria.ac.uk)
  • however, the mechanism of psychiatric disorder development remains unclear. (biomedcentral.com)