Chemical Warfare Agents
Chemical Warfare
Mustard Gas
Biological Warfare
Sarin
Phosphoric Triester Hydrolases
Soman
Organothiophosphorus Compounds
Decontamination
Organophosphates
Organophosphorus Compounds
Cholinesterase Inhibitors
Biological Warfare Agents
Military Medicine
Persian Gulf Syndrome
Psychological Warfare
Determination of alkylmethylphosphonic acids, the main metabolites of organophosphorus nerve agents, in biofluids by gas chromatography-mass spectrometry and liquid-liquid-solid-phase-transfer-catalyzed pentafluorobenzylation. (1/269)
A simple gas chromatography-mass spectrometry (GC-MS) procedure has been developed for the main metabolites of organophosphorus nerve agents, alkylmethylphosphonic acids (AMPAs; alkyl = Et, i-Pr, and pinacolyl) in biofluids via extractive pentafluorobenzylation. The derivatization was carried out under liquid-liquid-solid-phase-transfer conditions using a polymer-bound tri-n-butylmethylphosphonium bromide as a catalyst. AMPAs in aqueous samples were semiquantitatively extracted into a small-volume organic layer as their pentafluorobenzyl derivatives at pH 4.5 (85 degrees C). Sample pretreatments for urine, serum, and saliva were each examined to minimize matrix interference. The detection limits of APMAs by electron-impact ionization GC-MS were around 50 ng/mL and 2.5-10 ng/mL in the full-scan and selected-ion monitoring modes, respectively. In order to detect trace-level AMPAs, negative-ion chemical ionization (NICI) was also employed to enhance sensitivity. The detection limits of AMPAs in biofluids were typically 60 pg/mL by GC-NICI-MS. (+info)Chemical and biological weapons: new questions, new answers. (2/269)
The words "chemical and biological weapons" (CBW) send a shiver down most spines these days. With the end of the Cold War, the possibility of a massive nuclear confrontation appears remote, so today many popular doomsday scenarios center on the aggressive use of chemical or biological warfare by rogue nations or terrorist groups. As exaggerated as some of the accounts are, with CBW cast as the latest unseen, unstoppable enemy, the threat posed by these weapons is all too real, and growing. (+info)The sources, fate, and toxicity of chemical warfare agent degradation products. (3/269)
We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent degradation products relevant to environmental and occupational health. These parent CW agents include several vesicants: sulfur mustards [undistilled sulfur mustard (H), sulfur mustard (HD), and an HD/agent T mixture (HT)]; nitrogen mustards [ethylbis(2-chloroethyl)amine (HN1), methylbis(2-chloroethyl)amine (HN2), tris(2-chloroethyl)amine (HN3)], and Lewisite; four nerve agents (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX), tabun (GA), sarin (GB), and soman (GD)); and the blood agent cyanogen chloride. The degradation processes considered here include hydrolysis, microbial degradation, oxidation, and photolysis. We also briefly address decontamination but not combustion processes. Because CW agents are generally not considered very persistent, certain degradation products of significant persistence, even those that are not particularly toxic, may indicate previous CW agent presence or that degradation has occurred. Of those products for which there are data on both environmental fate and toxicity, only a few are both environmentally persistent and highly toxic. Major degradation products estimated to be of significant persistence (weeks to years) include thiodiglycol for HD; Lewisite oxide for Lewisite; and ethyl methyl phosphonic acid, methyl phosphonic acid, and possibly S-(2-diisopropylaminoethyl) methylphosphonothioic acid (EA 2192) for VX. Methyl phosphonic acid is also the ultimate hydrolysis product of both GB and GD. The GB product, isopropyl methylphosphonic acid, and a closely related contaminant of GB, diisopropyl methylphosphonate, are also persistent. Of all of these compounds, only Lewisite oxide and EA 2192 possess high mammalian toxicity. Unlike other CW agents, sulfur mustard agents (e.g., HD) are somewhat persistent; therefore, sites or conditions involving potential HD contamination should include an evaluation of both the agent and thiodiglycol. (+info)Hazards of chemical weapons release during war: new perspectives. (4/269)
The two major threat classes of chemical weapons are mustard gas and the nerve agents, and this has not changed in over 50 years. Both types are commonly called gases, but they are actually liquids that are not remarkably volatile. These agents were designed specifically to harm people by any route of exposure and to be effective at low doses. Mustard gas was used in World War I, and the nerve agents were developed shortly before, during, and after World War II. Our perception of the potency of chemical weapons has changed, as well as our concern over potential effects of prolonged exposures to low doses and potential target populations that include women and children. Many of the toxicologic studies and human toxicity estimates for both mustard and nerve agents were designed for the purpose of quickly developing maximal casualties in the least sensitive male soldier. The "toxicity" of the chemical weapons has not changed, but our perception of "toxicity" has. (+info)Sequelae of sarin toxicity at one and three years after exposure in Matsumoto, Japan. (5/269)
In order to clarify the later sequelae of sarin poisoning that occurred in Matsumoto City, Japan, on June 27, 1994, a cohort study was conducted on all persons (2052 Japanese people) inhabiting an area 1050 meters from north to south and 850 meters from east to west with the sarin release site in the center. Respondents numbered 1237 and 836 people when surveys were conducted at one and three years after the sarin incident, respectively. Numbers of persons with symptoms of sarin toxicity were compared between sarin victims and non-victims. Of the respondents, 58 and 46 people had symptoms associated with sarin such as fatigue, asthenia, shoulder stiffness, asthenopia and blurred vision at both points of the survey, respectively. The prevalences were low; some complained of insomnia, had bad dreams, difficulty in smoking, husky voice, slight fever and palpitation. The victims who had symptoms one year after the incident had a lower erythrocyte cholinesterase activity than did those who did not have symptoms at the early stage; such persons lived in an area with a 500 meter long axis north east from the sarin release site. The three-year cohort study clearly showed that the odds ratios of almost all of the symptoms were high in the sarin-exposed group, suggesting a positive relationship between symptoms and grades of exposure to sarin. These results suggest that symptoms reported by many victims of the sarin incident are thought to be sequelae related to sarin exposure. (+info)Characterization of VX on concrete using ion trap secondary ionization mass spectrometry. (6/269)
The nerve agent VX (O-ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate) was analyzed on the surface of concrete samples using an ion trap secondary ion mass spectrometer (IT-SIMS). It was found that VX could be detected down to an absolute quantity of 5 ng on a concrete chip, or to a surface coverage of 0.0004 monolayers on crushed concrete. To achieve these levels of detection, the m/z 268-->128 ion fragmentation was measured using MS2, where m/z 268 corresponds to [VX + H]+, and 128 corresponds to a diisopropylvinylammonium isomer, that is formed by the elimination of the phosphonothiolate moiety. Detection at these levels was accomplished by analyzing samples that had been recently exposed to VX, i.e., within an hour. When the VX-exposed concrete samples were aged, the SIMS signature for intact VX had disappeared, which signaled the degradation of the compound on the concrete surface. The VX signature was replaced by ions which are interpreted in terms of VX degradation products, which appear to be somewhat long lived on the concrete surface. These compounds include ethylmethylphosphonic acid (EMPA), diisopropyl taurine (DIPT), diisopropylaminoethanethiol (DESH), bis(diisopropylaminoethane) disulfide [(DES)2], and a particularly tenacious compound that may correspond to diisopropylvinylamine (DIVA), or an isomer thereof. It was found that the thiolamine-derived degradation products DIPT, DESH, and (DES)2 were removed with isopropyl alcohol extraction. However, the DIVA-related degradation product was observed to strongly adhere to the concrete surface for longer than one week. Although quantitation was not possible in this set of experiments, the results clearly show the rapid degradation of VX on concrete, as well as the surface sensitivity of the IT-SIMS for intact VX and its adsorptive degradation products. (+info)The binding of substrate analogs to phosphotriesterase. (7/269)
Phosphotriesterase (PTE) from Pseudomonas diminuta catalyzes the detoxification of organophosphates such as the widely utilized insecticide paraoxon and the chemical warfare agent sarin. The three-dimensional structure of the enzyme is known from high resolution x-ray crystallographic analyses. Each subunit of the homodimer folds into a so-called TIM barrel, with eight strands of parallel beta-sheet. The two zinc ions required for activity are positioned at the C-terminal portion of the beta-barrel. Here, we describe the three-dimensional structure of PTE complexed with the inhibitor diisopropyl methyl phosphonate, which serves as a mimic for sarin. Additionally, the structure of the enzyme complexed with triethyl phosphate is also presented. In the case of the PTE-diisopropyl methyl phosphonate complex, the phosphoryl oxygen of the inhibitor coordinates to the more solvent-exposed zinc ion (2.5 A), thereby lending support to the presumed catalytic mechanism involving metal coordination of the substrate. In the PTE-triethyl phosphate complex, the phosphoryl oxygen of the inhibitor is positioned at 3.4 A from the more solvent-exposed zinc ion. The two structures described in this report provide additional molecular understanding for the ability of this remarkable enzyme to hydrolyze such a wide range of organophosphorus substrates. (+info)Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. (8/269)
Acute neurotoxic effects of sarin (O:-isopropylmethylphosphonoflouridate) in male Sprague-Dawley rats were studied. The animals were treated with intramuscular (im) injections of either 1 x LD(50) (100 microg/kg), and sacrificed at 0. 5, 1, 3, 6, 15, or 20 h after treatment, or with im injections of either 0.01, 0.1, 0.5, or 1 x LD(50) and sacrificed 15 h after treatment. Plasma butyrylcholinesterase (BChE) and brain regional acetylcholinesterase (AChE) were inhibited (45-55%) by 30 min after the LD(50) dose. BChE in the plasma and AChE in cortex, brainstem, midbrain, and cerebellum remained inhibited for up to 20 h following a single LD(50) treatment. No inhibition in plasma BChE activity was observed 20 h after treatment with doses lower than the LD(50) dose. Midbrain and brainstem seem to be most responsive to sarin treatment at lower doses, as these regions exhibited inhibition (approximately 49% and 10%, respectively) in AChE activity following 0.1 x LD(50) treatment, after 20 h. Choline acetyltransferase (ChAT) activity was increased in cortex, brainstem, and midbrain 6 h after LD(50) treatment, and the elevated enzyme activity persisted up to 20 h after treatment. Cortex ChAT activity was significantly increased following a 0.1 x LD(50) dose, whereas brainstem and midbrain did not show any effect at lower doses. Treatment with an LD(50) dose caused a biphasic response in cortical nicotinic acetylcholine receptor (nAChR) and muscarinic acetylcholine receptor (m2-mAChR) ligand binding, using [(3)H]cytisine and [(3)H]AFDX-384 as ligands for nAChR and mAChR, respectively. Decreases at 1 and 3 h and consistent increases at 6, 15, and 20 h in nAChR and m2-mAChR were observed following a single LD(50) dose. The increase in nAChR ligand binding densities was much more pronounced than in mAChR. These results suggest that a single exposure of sarin, ranging from 0.1 to 1 x LD(50), modulates the cholinergic pathways differently and thereby causes dysregulation in excitatory neurotransmission. (+info)There are several types of salivary gland diseases, including:
1. Parotid gland disease: This type of disease affects the parotid gland, which is located in the jaw and produces saliva to aid in digestion.
2. Sublingual gland disease: This type of disease affects the sublingual gland, which is located under the tongue and produces saliva to keep the mouth moist.
3. Submandibular gland disease: This type of disease affects the submandibular gland, which is located below the jaw and produces saliva to aid in digestion.
4. Mucocele: This is a benign tumor that occurs in the salivary glands and can cause swelling and pain.
5. Mucoceles: These are benign tumors that occur in the salivary glands and can cause swelling and pain.
6. Salivary gland stones: This is a condition where small stones form in the salivary glands and can cause pain and swelling.
7. Salivary gland cancer: This is a type of cancer that affects the salivary glands and can be treated with surgery, radiation therapy, or chemotherapy.
8. Sialadenitis: This is an inflammation of the salivary glands that can cause pain, swelling, and difficulty swallowing.
9. Sialosis: This is a condition where the salivary glands become blocked and cannot produce saliva.
10. Salivary gland cysts: These are fluid-filled sacs that occur in the salivary glands and can cause pain, swelling, and difficulty swallowing.
Salivary gland diseases can be diagnosed through a variety of tests, including imaging studies, biopsies, and blood tests. Treatment for these conditions depends on the specific type of disease and may include medications, surgery, or radiation therapy.
The cause of PGS is not well understood and has been the subject of much debate and research. Some theories suggest that it may be related to exposure to chemical weapons, pesticides, or other toxic substances used during the war. Others have suggested that it may be due to stress-related factors, such as deployment in a combat zone and the psychological effects of war.
There is no single definition of PGS, but rather a range of symptoms and conditions that have been observed among Gulf War veterans. The U.S. Department of Veterans Affairs has recognized PGS as a condition that can be service-connected, meaning that it may be eligible for disability compensation for veterans who are affected by the syndrome.
PGS is also known as 'Gulf War Illness' or 'Gulf War Syndrome.' It is important to note that not all military personnel who served in the Gulf War have developed PGS, and the syndrome is not unique to the Gulf War. Similar symptoms have been reported by veterans of other conflicts, as well as by civilians who were exposed to environmental toxins or stressors.
A burn that is caused by direct contact with a chemical substance or agent, such as a strong acid or base, and results in damage to the skin and underlying tissues. Chemical burns can be particularly severe and may require extensive treatment, including surgery and skin grafting.
Examples of how Burns, Chemical is used in medical literature:
1. "The patient sustained a chemical burn on her hand when she spilled a beaker of sulfuric acid."
2. "The burn team was called in to treat the victim of a chemical explosion, who had suffered extensive burns, including chemical burns to his face and arms."
3. "The patient was admitted with severe chemical burns on her legs and feet, caused by exposure to a corrosive substance at work."
4. "Chemical burns can be difficult to treat, as they may require specialized equipment and techniques to remove the damaged tissue and promote healing."
5. "The patient required multiple debridements and skin grafting procedures to treat her chemical burns, which had resulted in extensive scarring and disfigurement."
There are several types of eye burns, including:
1. Chemical burns: These occur when the eye comes into contact with a corrosive substance, such as bleach or drain cleaner.
2. Thermal burns: These occur when the eye is exposed to heat or flames, such as from a fire or a hot surface.
3. Ultraviolet (UV) burns: These occur when the eye is exposed to UV radiation, such as from the sun or a tanning bed.
4. Radiation burns: These occur when the eye is exposed to ionizing radiation, such as from a nuclear accident or cancer treatment.
Symptoms of eye burns can include:
* Pain and redness in the eye
* Discharge or crusting around the eye
* Blurred vision or sensitivity to light
* Swelling of the eyelids or the surface of the eye
* Increased tearing or dryness
Treatment for eye burns depends on the cause and severity of the injury. Mild cases may require only topical medications, such as antibiotic ointments or anti-inflammatory drops. More severe cases may require more aggressive treatment, such as oral medications, patching, or even surgery. In some cases, eye burns can lead to long-term vision problems or scarring, so it is important to seek medical attention if symptoms persist or worsen over time.
List of chemical warfare agents
Microbial toxin
History of biological warfare
VS (nerve agent)
O-Mustard
Arsenical
Ethylsarin
Monofluorophosphate
Ricin
Lewisite 3
Lewisite 2
OPA mixture
Methyldichlorophosphine
Chlorosoman
Ethyl iodoacetate
Lewisite
Arsenic compounds
Flaccid paralysis
Carbamate
Tokyo subway sarin attack
Methyldichloroarsine
Cholinesterase inhibitor
Phenyldichloroarsine
T-1123
Arsenic
Native Americans in the United States
Strychnine
Blood agent
Henry Bouquet
Point State Park
Incendiary device
Operation Bernhard
Mobile Mail-Screening Station
Terminal ballistics
Chloromethyl chloroformate
1944 New Year Honours
2019 Turkish offensive into north-eastern Syria
Arma 3
Rhodesia and weapons of mass destruction
Deseret Test Center
Operation Masher
Alabama Regional Communications System
Firestarter: Rekindled
Skinny Puppy
Internet of things
Rihab Taha
Sodium hypochlorite
GRU
Wounded in action
CNS (chemical weapon)
Cyanogen chloride
EA-3834
Jin Kim Montclare
Sverdlovsk anthrax leak
Iraqi biological weapons program
Enzyme inhibitor
Russian war crimes
Biofouling
Shirqat offensive (2016)
Yan Xishan
CDC - Chemical Weapons Elimination - Chemical Warfare Agent Exposure Limits Fact Sheet
CBRNE - Chemical Warfare Agents: Overview, General Considerations, Nerve Agents - Properties and Clinical Effects
Browsing WHA24 by Subject "Chemical Warfare Agents"
Warfare and Terrorism Agents (used in acts of war or terror) | Chemical Classifications | Toxic Substance Portal | ATSDR
Systemic Asphyxiant Chemical-Warfare Agents - Injuries; Poisoning - Merck Manuals Professional Edition
Subjects: Chemical Warfare Agents - Digital Collections - National Library of Medicine Search Results
Results of search for 'su:{Chemical warfare agents.}'
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WHO HQ Library catalog
Letter C (1997-Present)
Tokyo subway sarin attack - Wikipedia
Cancer morbidity in British military veterans included in chemical warfare agent experiments at Porton Down: cohort study. -...
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The Automatic Earth: March 14 2009: Less cities more moving people
Toxicity4
- Somani SM, Husain K. Low-level nerve agent toxicity under normal and stressful conditions. (cdc.gov)
- Nerve agent or organophosphate toxicity might result from multiple routes of exposure. (cdc.gov)
- To learn more, see Considerations in developing medical countermeasures against chemical ocular toxicity , published in Toxicology Letters. (nih.gov)
- Very little information is available on the long-term toxicity of agent T, which has much lower volatility than H, with which it is mixed. (cdc.gov)
Toxicology2
Nerve agent7
- Nerve agent (GA, GB, and VX) exposure limits were revised in 2003. (cdc.gov)
- A review of nerve agent exposure for the critical care physician. (cdc.gov)
- A clinically compatible case in which a high index of suspicion (credible threat or patient history regarding location and time) exists for nerve agent or organophosphate pesticide exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. (cdc.gov)
- Chemical warfare: nerve agent poisoning. (cdc.gov)
- Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates. (nih.gov)
- Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. (nih.gov)
- The intelligence community assesses with "high confidence" that officers of Russia's Federal Security Service used a nerve agent to poison Russian opposition leader Aleksey Navalny on August 20, 2020. (whitehouse.gov)
Countermeasures Against Chemical Threats1
- This Funding Opportunity Announcement (FOA) encourages grant applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01s). (nih.gov)
Sarin2
- They include traditional chemical warfare nerve agents such as sarin and VX, and toxic industrial chemicals and pesticides such as cyanide, chlorine, parathion, and sodium fluoroacetate. (nih.gov)
- This paper aims at explaining the lessons learned from the chemical attacks that took place in 2013 in the Syrian military conflict, especially the sarin attacks on the Ghouta area of Damascus on August 21. (mdpi.com)
Cyanide1
- Chemicals such as phosgene, cyanide, anhydrous ammonia, and chlorine are important precursors for manufacturing many products including plastics and agricultural products, and are widely and frequently transported. (medscape.com)
Insecticides1
- Like a number of widely used insecticides, the nerve agents GA, GB, and VX are organic compounds containing phosphorus (organophosphorus compounds). (cdc.gov)
Phosgene1
- Discovery of MCMs and/or therapeutic target(s) to prevent and treat lung damage (including pulmonary edema, pulmonary capillary leak, and pulmonary fibrosis) resulting from exposure to agents such as sulfur mustard, chlorine, acrolein, and phosgene. (nih.gov)
Poisoning2
- A case in which a potentially exposed person is being evaluated by health-care workers or public health officials for poisoning by a particular chemical agent, but no specific credible threat exists. (cdc.gov)
- Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. (nih.gov)
Chlorine1
- In the modern warfare era, CWAs were first used in World War I in 1915 when the German military released 168 tons of chlorine gas at Ypres, Belgium, killing an estimated 5000 Allied troops. (medscape.com)
Mass-casualty2
- Overview of Chemical-Warfare Agents Chemical-warfare (CW) agents are chemical mass-casualty weapons (MCWs) developed by governments for wartime use and include Toxic agents (intended to cause serious injury or death) Incapacitating. (merckmanuals.com)
- The Chemical Countermeasures Research Program ( CCRP ) was established in 2006 by the NIAID to promote the discovery and advancements of MCMs to treat and/or prevent serious morbidities and mortality during or after mass casualty, high consequence, public health events involving the release of highly toxic chemicals. (nih.gov)
Exposure to chemical1
- The objective of this study was to examine both self-reported mTBI and exposure to chemical/biological weapons (CBW) as a multiple or two hit model for increased risk of GWI and other chronic health conditions. (cdc.gov)
Blister Agents2
- This investigation was prompted by reports from Gulf War veterans who, after the cease-fire, saw what they believed was evidence of Iraq s use of blister agents one category of chemical warfare agent against Iraqi civilians. (osd.mil)
- We were unable to obtain definitive evidence of Iraq's post-war use of blister agents or any other kind of chemical warfare agent. (osd.mil)
Inhalation2
- Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a significant threat to both military and civilian populations. (nih.gov)
- An effective defense requires the development of unique respirator systems that prevent inhalation of chemical warfare (CW) agents. (sbir.gov)
Injuries2
- For patient education information, also see the First Aid and Injuries Center , as well as Chemical Warfare and Personal Protective Equipment . (medscape.com)
- To learn more, see Developing Medical Countermeasures to Treat the Acute and Chronic Effects of Pulmonary Chemical Injuries (A Trans-Agency Scientific Meeting) . (nih.gov)
Iraqi1
- The Iraqi military also used chemical weapons against the Iraqi Kurds during the second Persian Gulf War. (medscape.com)
Toxic chemicals1
- Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. (nih.gov)
Sulfur mustard2
- Sulfur mustard was the major cause of chemical casualties in World War I. CWAs have been used in at least 12 conflicts since, including the first Persian Gulf War (Iraq-Iran War). (medscape.com)
- Discovery of MCMs and/or therapeutic target(s) to mitigate dermal and/or ocular toxicities after exposure to vesicating agents such as sulfur mustard, nitrogen mustard, and Lewisite. (nih.gov)
Defense3
- In 1970, Congress gave the Department of Health and Human Services (DHHS) responsibility for reviewing Department of Defense (DOD) plans for transporting and/or disposing of certain chemical agents and making recommendations for the protection of human health and safety (Public Law (Pub. (cdc.gov)
- The Syrian upraising, which started in 2011, brought great concern among the Chemical Defense Community, due to the fact that, until October 14, 2013, Syria was one of the seven non-State Parties of the Chemical Weapons Convention (CWC). (mdpi.com)
- Defense against chemical weapons is a critical DoD requirement. (sbir.gov)
Civilians1
- Civilians have also been exposed inadvertently to chemical weapons many years after weapons deployment during war. (medscape.com)
Acute exposure2
- therefore, CDC, through open meetings, convened a working group of experts to consider adverse effects of acute exposure to these agents. (cdc.gov)
- During public meetings held at each of the eight sites, citizens voiced their concerns about chronic low-level exposure to the agents and the delayed effects that acute exposure might cause. (cdc.gov)
Decontamination1
- Lavoie FW, Coomes T, Cisek JE, Fulkerson L. Emergency department external decontamination for hazardous chemical exposure. (cdc.gov)
Threats4
- Public information on biological and chemical threats. (who.int)
- Biological and chemical threats. (who.int)
- The NIAID is inviting administrative supplement applications from current NIAID awardees that are not currently focused on the research and early development of medical countermeasures (MCMs) against chemical threats to allow them to expand their MCM research focus into this critical field. (nih.gov)
- The mission of the CounterACT U01 program is to develop new and improved therapeutics for chemical threats. (nih.gov)
19971
- The CWC is an international treaty that entered into force in 1997 and prohibits the development, production, acquisition, stockpiling, retention, transfer or use of chemical weapons (CW) [ 1 , 2 ]. (mdpi.com)
Lewisite2
Compounds1
- Organophosphates englobe the class of highly toxic compounds present in many agrochemicals and threatening chemical weapons [ 1 ]. (degruyter.com)
Injury1
- The multiple hit hypothesis for Gulf War Illness: self-reported chemical/biological weapons exposure and mild traumatic brain injury. (cdc.gov)
Weapons12
- Although the Chemical Weapons Convention and a number of international treaties have banned the development, production, and stockpiling of those CWAs with only a warfare use, these agents reportedly still are being produced or stockpiled in several countries. (medscape.com)
- Within the last several decades, terrorists have deployed chemical weapons against civilian populations. (medscape.com)
- Health aspects of chemical and biological weapons : report of a WHO group of consultants. (who.int)
- Public health response to biological and chemical weapons : WHO guidance. (who.int)
- Despite the limitations the UN Mission found while investigating the use of chemical weapons (CW) in Syria, some interesting conclusions for the scientific and medical community can be obtained from its reports. (mdpi.com)
- These include the advantages of the Chemical Weapons Convention procedure for the investigation of alleged CW use, when compared with the United Nations mechanism for similar investigations, the difficulties of differential diagnosis based only on clinical signs and symptoms and the impact of secondary contamination when responding to a CW attack. (mdpi.com)
- Between 1991 and 1999, some 175 ADF personnel deployed to Iraq with UNSCOM - the UN mission that sought to oversee Iraq's compliance with the destruction of its chemical, biological and missile weapons facilities. (awm.gov.au)
- We are also working with Congress to ensure we're faithfully implementing the Chemical and Biological Weapons Act. (whitehouse.gov)
- Today, the United States is announcing sanctions on seven senior members of the Russian government, an expansion of sanctions under the Chemical and Biological Weapons Control and Warfare Elimination Act, new export restrictions on items that could be used for biological agent and chemical production, and visa restrictions. (whitehouse.gov)
- And, it is to develop plans for using nuclear weapons to retaliate against chemical or biological attacks, as well as "surprising military developments" of an unspecified nature. (latimes.com)
- They seek a host of new weapons and support systems, including conventional military and cyber warfare capabilities integrated with nuclear warfare. (latimes.com)
- The NPR says they "could be employed against targets able to withstand nonnuclear attack," or in retaliation for the use of nuclear, biological, or chemical weapons, or "in the event of surprising military developments. (latimes.com)
Possibility2
Defence1
- Medical manual of defence against chemical agents / by command of the Defence Council. (who.int)
Infectious1
- Infectious agents can be spread through contact with blood, bodily fluids, respiratory secretions, or contaminated materials or surfaces. (cdc.gov)
Aspects of chemical1
- Textbook of military medicine: medical aspects of chemical and biological warfare. (cdc.gov)
Analytical1
- Selected analytical methods: chemical methods query [online]. (cdc.gov)
Clinical2
- To illustrate these principles with specific agents, the properties, clinical effects, and medical management of nerve agents and vesicant agents are reviewed briefly. (medscape.com)
- The case can be confirmed if laboratory testing was not performed because either a predominant amount of clinical and nonspecific laboratory evidence of a particular chemical was present or the etiology of the agent is known with 100% certainty. (cdc.gov)
Explosives1
- Warfare or terrorism agents are a class that includes chemicals, biological substances, radioactive materials, nuclear materials, or explosives. (cdc.gov)
Search1
- Results of search for 'su:{Chemical warfare agents. (who.int)
Subject3
- However, for the avoidance of any doubt, if you are advised by or bidding through an agent on a lot identified as being subject to a third party guarantee you should always ask your agent to confirm whether or not he or she has a financial interest in relation to the lot. (christies.com)
- Amongst works of the same subject, Agent Orange (In the Milky Lake) is the one of the biggest three in terms of size. (christies.com)
- Along with the eloquent use of the water imagery in Agent Orange (In the Milky Lake) is the artist's anti-war sentiment - it is a subject matter that greatly concerns him. (christies.com)
Medical3
- The Chemical Hazards Emergency Medical Management (CHEMM) portal sponsored by the US Department of Health & Human Services provides comprehensive information on chemical incident management, including specific information for first responders, hospital providers, and incident preparedness, as well as the general public . (medscape.com)
- To learn more, see The National Institutes of Health Chemical Countermeasures Research Program (NIH CCRP): A Collaborative Opportunity to Develop Effective and Accessible Chemical Medical Countermeasures for the American People , published in Drug Development Research. (nih.gov)
- We also interviewed numerous medical specialists, including doctors, nurses, and physician assistants, as well as chemical warfare experts. (osd.mil)
Effects1
- The group studied published and unpublished reports of all potential adverse effects, including carcinogenicity, mutagenicity, and teratogenicity, for the aforementioned agents. (cdc.gov)
History1
- The reports, combined with Iraq s long history of chemical warfare agent use, suggested that Iraq might have used these agents to suppress the post-war rebellion, possibly exposing US forces. (osd.mil)
Concerns2
- To resolve questions about these concerns, CDC gathered data on these agents and held an open meeting with the working group on September 29-30, 1987, in Atlanta, Georgia. (cdc.gov)
- The Roundup method has the chemical cost and attendant concerns while the cultivation method is much more fuel intensive. (blogspot.com)
Health2
Industrial1
- Accidents involving toxic industrial chemicals continue to be a significant potential source of exposure to those agents that were also used as chemical warfare agents. (medscape.com)
Destruction1
- L. 99-145 (50 USC 1521), which mandates destruction of the present stockpile of selected chemical agents by September 30, 1994. (cdc.gov)
Carcinogenic1
- None of the nerve agents have been shown to be mutagenic or carcinogenic. (cdc.gov)
Terrorist1
- [ 2 ] inadvertent contact with chemical-laden shells from an unknown military dump site, military stockpiling, war, or terrorist attack. (medscape.com)
Treatment1
- Indeed, not only was chlorpromazine successful-by 1964 some 50 million people had taken the drug-but its development also laid the groundwork for the later generation of agents used in the treatment of anxiety and depression. (britannica.com)
Result1
- The purpose of this investigation was to determine if Iraq used chemical warfare agents to suppress the Shiia rebellion in southern Iraq after the Gulf War and if US forces were exposed to these agents as a result of any such use. (osd.mil)
Army1
- In addition, the U.S. Army Surgeon General's Office summarized a number of studies now under way or recently completed for agents GB, VX, HD, and L. (cdc.gov)