Berberine Alkaloids
Papaveraceae
The poppy plant family of the order Papaverales, subclass Magnoliidae, class Magnoliopsida. These have bisexual, regular, cup-shaped flowers with one superior pistil and many stamens; 2 or 3 conspicuous, separate sepals and a number of separate petals. The fruit is a capsule. Leaves are usually deeply cut or divided into leaflets.
p-Dimethylaminoazobenzene
Homeopathy
Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice. (1/15)
BACKGROUND: Crude extracts of Chelidonium majus, and also purified compounds derived from crude extracts of this plant, have been reported to exhibit anti-viral, anti-inflammatory, anti-tumor and anti-microbial properties both in vitro and in vivo. Chelidonium is a homeopathic drug routinely used against various liver disorders including cancer in humans. Two potencies of Chelidonium (Ch-30, Ch-200) have been tested for their possible anti-tumor and enzyme modulating activities in liver and anti-clastogenic effects during p-DAB-induced hepatocarcinogenesis in mice compared to suitable controls. METHODS: Several cytogenetic and enzymatic protocols were used at three fixation intervals; at 60 days, 90 days and 120 days of treatment. Different sets of healthy mice were fed: i) hepatocarcinogen, p-DAB plus phenobarbital (PB), ii) only PB, iii) neither p-DAB nor PB (normal control). One set of mice fed with p-DAB plus PB was also fed Ch-30 (iv) and another set Ch-200 (v). All standard currently used methods were adopted for cytogenetical preparations and for the enzyme assays. RESULTS: All group (i) mice developed tumors in liver at all fixation intervals, while none of group (ii) and (iii) mice developed any tumors. About 40% mice in group (iv) and group (v) did not show tumor nodules in their liver. Feeding of Chelidonium to group (iv) and (v) mice reduced genotoxic effects to a significant extent (p < 0.05 to p < 0.001). CONCLUSION: The homeopathic drug Chelidonium exhibited anti-tumor and anti-genotoxic activities and also favorably modulated activities of some marker enzymes. Microdoses of Chelidonium may be effectively used in combating liver cancer. (+info)Optimization of the separation of some Chelidonium maius L. alkaloids by reversed phase high-performance liquid chromatography using cyanopropyl bonded stationary phase. (2/15)
The high-performance liquid chromatographic method using two stationary phases: RP-18 and cyanopropyl silica for the analysis of some alkaloids in Chelidonium maius L. extracts is performed. The extract was chromatographed using a mobile phase composed of an organic modifier (acetonitrile, methanol, tetrahydrofuran or 1,4-dioxan), phosphate buffer and sodium octadecylsulfate or di (2-ethyl hexyl) orthophosphoric acid (HDEHP) as ion-pairing reagents. The influence of the different kind of stationary phase and organic modifiers on retention has been compared. In order to improve the selectivity of separation and peak shape, gradient elution was applied. (+info)Ukrain - a new cancer cure? A systematic review of randomised clinical trials. (3/15)
BACKGROUND: Ukrain is an anticancer drug based on the extract of the plant Chelidonium majus L. Numerous pre-clinical and clinical investigations seem to suggest that Ukrain is pharmacologically active and clinically effective. We wanted therefore to critically evaluate the clinical trial data in the form of a systematic review. METHODS: Seven electronic databases were searched for all relevant randomised clinical trials. Data were extracted and validated by both authors, tabulated and summarised narratively. The methodological quality was assessed with the Jadad score. RESULTS: Seven trials met our inclusion criteria. Without exception, their findings suggest that Ukrain has curative effects on a range of cancers. However, the methodological quality of most studies was poor. In addition, the interpretation of several trials was impeded by other problems. CONCLUSION: The data from randomised clinical trials suggest Ukrain to have potential as an anticancer drug. However, numerous caveats prevent a positive conclusion, and independent rigorous studies are urgently needed. (+info)Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. (4/15)
BACKGROUND: The anticancer drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L. alkaloid chelidonine and the alkylans thiotepa was reported to exert selective cytotoxic effects on human tumour cell lines in vitro. Few clinical trials suggest beneficial effects in the treatment of human cancer. Aim of the present study was to elucidate the importance of apoptosis induction for the antineoplastic activity of Ukrain, to define the molecular mechanism of its cytotoxic effects and to identify its active constituents by mass spectrometry. METHODS: Apoptosis induction was analysed in a Jurkat T-lymphoma cell model by fluorescence microscopy (chromatin condensation and nuclear fragmentation), flow cytometry (cellular shrinkage, depolarisation of the mitochondrial membrane potential, caspase-activation) and Western blot analysis (caspase-activation). Composition of Ukrain was analysed by mass spectrometry and LC-MS coupling. RESULTS: Ukrain turned out to be a potent inducer of apoptosis. Mechanistic analyses revealed that Ukrain induced depolarisation of the mitochondrial membrane potential and activation of caspases. Lack of caspase-8, expression of cFLIP-L and resistance to death receptor ligand-induced apoptosis failed to inhibit Ukrain-induced apoptosis while lack of FADD caused a delay but not abrogation of Ukrain-induced apoptosis pointing to a death receptor independent signalling pathway. In contrast, the broad spectrum caspase-inhibitor zVAD-fmk blocked Ukrain-induced cell death. Moreover, over-expression of Bcl-2 or Bcl-xL and expression of dominant negative caspase-9 partially reduced Ukrain-induced apoptosis pointing to Bcl-2 controlled mitochondrial signalling events. However, mass spectrometric analysis of Ukrain failed to detect the suggested trimeric chelidonine thiophosphortriamide or putative dimeric or monomeric chelidonine thiophosphortriamide intermediates from chemical synthesis. Instead, the Chelidonium majus L. alkaloids chelidonine, sanguinarine, chelerythrine, protopine and allocryptopine were identified as major components of Ukrain. Apart from sanguinarine and chelerythrine, chelidonine turned out to be a potent inducer of apoptosis triggering cell death at concentrations of 0.001 mM, while protopine and allocryptopine were less effective. Similar to Ukrain, apoptosis signalling of chelidonine involved Bcl-2 controlled mitochondrial alterations and caspase-activation. CONCLUSION: The potent proapoptotic effects of Ukrain are not due to the suggested "Ukrain-molecule" but to the cytotoxic efficacy of Chelidonium majus L. alkaloids including chelidonine. (+info)8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. (5/15)
Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (microM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE. (+info)Nucleases isolated from Chelidonium majus L. milky sap can induce apoptosis in human cervical carcinoma HeLa cells but not in Chinese Hamster Ovary CHO cells. (6/15)
(+info)Oidium neolycopersici: intraspecific variability inferred from amplified fragment length polymorphism analysis and relationship with closely related powdery mildew fungi infecting various plant species. (7/15)
(+info)Drug-induced liver injury due to "natural products" used for weight loss: a case report. (8/15)
Taking herbal-extracts to lose weight is an underestimated health hazard. Often, these products contain active agents that can cause acute liver damage. In this case report, a 22-year-old female patient, who presented with a feature of cholestatic syndrome, was so sure that the "natural products" were not dangerous that she did not inform her physicians that she had taken them, making their task that much more challenging. Clinical presentation mimicked acute cholecystitis and the patient underwent a cholecystectomy. Surgery was without any consequences and complications, although it did not completely cure the illness. She later admitted to having taken herbal remedies and this led to the correct diagnosis of phytotherapy-related hepatotoxicity and a successful therapeutic approach. The true incidence of phytotherapy-related hepatotoxicity and its pathogenic mechanisms are largely unknown. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies. (+info)Glistnik jaskółcze ziele (Chelidonium majus L.) we współczesnej terapii - wskazania i bezpieczeństwo stosowania • Postępy...
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Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their...
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Comparison of the efficacy of different doses of Ukrain in the combined treatment of breast cancer. • Arctic Health
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Chelidonium
... The Plant List Media related to Chelidonium (Papaveraceae) at Wikimedia Commons Data related to Chelidonium at ... Chelidonium is a small genus, consisting of two to three species, depending on the taxonomic treatment. These are: "Chelidonium ... Chelidonium, commonly known as celandines, is a small genus of flowering plants in the poppy family, This genus is native to ... "Chelidonium". Flora of China. Vol. 7 - via eFloras.org, Missouri Botanical Garden, St. Louis, MO & Harvard University Herbaria ...
Lactarius chelidonium
... is a member of the large milk-cap genus Lactarius in the order Russulales. It was first described by ... Lactarius chelidonium in Index Fungorum (Articles with short description, Short description matches Wikidata, Articles with ' ... List of Lactarius species "Lactarius chelidonium Peck 1872". MycoBank. International Mycological Association. Retrieved 2011-06 ...
Chelidonium majus
Chelidonium was a favourite herb of the French herbalist Maurice Mességué. Chelidonium majus has traditionally been used for ... Chelidonium is used to make Ukrain, a drug that has been promoted for, but is not known to be effective for, the treatment of ... Chelidonium majus is native in most regions of Europe. It is also found in North Africa in Macaronesia, Algeria and Morocco. In ... Chelidonium majus, the greater celandine, is a perennial herbaceous flowering plant in the poppy family Papaveraceae. One of ...
Hygrophyte
Adoxa; Agrostis; Bidens; Caltha; Cardamine; Carex; Catabrosa; Chelidonium; Circea; Cyperus; Drosera; Equisetum; Galium; ...
Sanguinarine
Chelidonium majus; and Macleaya cordata. Sanguinarine is a toxin that kills animal cells through its action on the Na+/K+- ...
Flora of Malta
"Chelidonium majus". MaltaWildPlants.com. Retrieved 2022-01-04. Mifsud, Stephen. "Chenopodiastrum hybridum". MaltaWildPlants.com ...
List of Pelargonium species
Pelargonium chelidonium DC. Pelargonium citronellum J.J.A.van der Walt Pelargonium columbinum Jacq. Pelargonium confertum E.M. ...
Swallowwort
Cynanchum is from Greek words meaning "to choke a dog." Greater celandine (Chelidonium majus). Greater celandine and ...
List of Geraniales of South Africa
endemic Pelargonium chelidonium (Houtt.) DC. endemic Pelargonium citronellum J.J.A.van der Walt, endemic Pelargonium columbinum ... accepted as Pelargonium chelidonium (Houtt.) DC. present Pelargonium ribifolium Jacq. endemic Pelargonium riversdalense Knuth, ...
List of wort plants
Swallowwort - The Greater Celandine, Chelidonium majus. Also, any plant of the genus Asclepias or Cynanchum. Black Swallow-wort ... Tetterwort - According to 1913 Webster's Dictionary, Chelidonium majus in England or Sanguinaria canadensis in the Americas. ...
Iris scariosa
and Chelidonium majus L. var grandiflorum Willd. It grows on the alkaline and dry, sunny, open stony hillsides, beside ditches ...
List of poisonous plants
Rogelj B, Popovic T, Ritonja A, Strukelj B, Brzin J (November 1998). "Chelidocystatin, a novel phytocystatin from Chelidonium ...
Chelidonine
... is the major alkaloid component of Chelidonium majus. Chelidonium majus L. is the only species of the tribe ... D-Chelidonine, the main alkaloid of Chelidonium majus, was first isolated in 1839. The supposed healing properties of greater ... The first two have been isolated from the roots of Chelidonium majus L. as minor alkaloids. Enantiomeric (+)-norchelidonine has ... Bosisio, E. (1996). Pharmacological activities of Chelidonium majus L. (Papaveraceae). Elsevier, 33(2), 127-134. Kemeny-Beke, A ...
List of flora of Indiana
circumvagum (N) Chasmanthium latifolium (N) Chelidonium majus var. majus (I) Chelone glabra (N) Chenopodium album var. ...
Caffeoylmalic acid
It is also found in Chelidonium majus and Urtica dioica.[citation needed] Budzianowski J (January 1990). "Caffeoylmalic and two ... from Chelidonium majus*,1". Planta Medica. 59 (1): 71-5. doi:10.1055/s-2006-959608. PMID 17230338. v t e (Articles without EBI ...
Chelidonic acid
... was first discovered in extracts of Chelidonium majus. It occurs naturally in plants of the Asparagales order. ... Probst, Joseph M. A. (1839) "Beschreibung und Darstellungsweise einiger bei der Analyse des Chelidonium majus aufgefundenen ... Stoffe" (Description and methods of preparation of some substances found during the analysis of Chelidonium majus), Annalen der ...
University of Toronto President's Estate
Chelidonium majus and Muscari botrides. By 1982, many plants had germinated or been grown from cuttings and different species ...
Wart
Daily application of the latex of Chelidonium majus is a traditional treatment. The acrid yellow sap of Greater Celandine is ... Chelidonium majus-an integrative review: traditional knowledge versus modern findings Forschende Komplementärmedizin/Research ...
Papaveroideae
Bocconia L. - Central and southern America, Antilles Chelidonium L. - Eurasia Dicranostigma Hook.f. & Thomson - Central Asia ...
Chelerythrine
... is a benzophenanthridine alkaloid present in the plant Chelidonium majus (greater celandine). It is a potent, ...
Papaveraceae
Bocconia L. - Central and southern America, Antilles Chelidonium L. - Eurasia Dicranostigma Hook.f. & Thomson - Central Asia ... Chelidonium majus) Eastern horned poppy (Dicranostigma erectum) Red horned poppy (Glaucium corniculatum) Snow-poppy (Eomecon ...
Thalamiflorae
Chelidonium, Hypecoum Ordo 10. Fumariaceae Genus: Diclytra, Adlumia, Cysticaptnos, Corydalis, Sarcocapnos, Fumaria Ordo 11. ...
Cornell Botanic Gardens
Poisonous Plants Garden Plants poisonous to livestock, including Atropa, Chelidonium, Cicuta, Digitalis, Lobelia, Phytolacca, ...
Ukrain
January 2006). "Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial ... is the trademarked name of a semi-synthetic substance derived from the plant Chelidonium majus and promoted as a drug to treat ... a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure". Cancer Letters. 160 (2): 237- ...
Herbarius moguntinus
... chapter 44 Chelidonium majus Part I, chapter 50 Dictamnus albus Part I, chapter 54 ..... Inula helenium Part I, chapter 59 ...
List of English words of Arabic origin (C-F)
... where curcuma is said to be a yellow root that can be used to dye clothes and is said to come from a Chelidonium-type plant - ... he also said kurkum can alternatively mean the yellow root of the Mediterranean plant Chelidonium majus - ref, ref. An early ...
Lactarius indigo
L. chelidonium has a yellowish to dingy yellow-brown to bluish-gray cap and yellowish to brown latex. L. quieticolor has blue- ... L. chelidonium and its variety chelidonioides, L. paradoxus, and L. hemicyaneus may be considered as mileposts along the road ...
Iroquois ethnobotany
Chelidonium majus, infusion mixed with another plant and milk given to pigs that drool and have sudden movements.: p.45 Abies ...
Marcin Hoffmann
August 2017). "Selectivity of major isoquinoline alkaloids from Chelidonium majus towards telomeric G-quadruplex: A study using ... Investigation of the mechanism of telomerase inhibition by Chelidonium majus isoquinoline alkaloids through stabilization of ... MSc in Biotechnology at the AMU Faculty of Biology for his thesis Properties of glycoproteins isolated from Chelidonium majus ...
List of unproven and disproven cancer treatments
Ukrain - the trademarked name of a drug (sometimes called "celandine") made from Chelidonium majus, a plant in the poppy family ...
Chelidonium Majus generalities - ABC Homeopathy
Homeopathic Chelidonium Majus - GENERALITIES indications, uses & symptoms from 12 cross linked materia medicas. Available 4X- ... Chelidonium Majus - Generalities symptoms Celandine, Chelidonium, Chelid, Chelidon, Chelidonin, Chel.. Available in 4X-30X, 3C- ... Have you ever used Chelidonium Majus? Yes No. Filter Chelidonium Majus generalities symptoms:. ... Chelidonium Majus. General Modalities Etc Relationships Mind Head Vertigo, Dizziness Eyes Nose Face Ears Skin Mouth Throat ...
Chelidonium Majus abdomen symptoms - ABC Homeopathy
Homeopathic Chelidonium Majus - ABDOMEN indications, uses & symptoms from 12 cross linked materia medicas. Available 4X-30X, 3C ... Chelidonium Majus - Abdomen symptoms Celandine, Chelidonium, Chelid, Chelidon, Chelidonin, Chel.. Available in 4X-30X, 3C-30C, ... Chelidonium Majus- main page Buy Chelidonium Majus. ABDOMEN. Abdomen. Stomach; Tongue yellow, with imprint of teeth; large and ... Have you ever used Chelidonium Majus? Yes No. Filter Chelidonium Majus abdomen symptoms:. ...
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CHELIDONIUM MAJUS (UNII: 7E889U5RNN) (CHELIDONIUM MAJUS - UNII:7E889U5RNN) CHELIDONIUM MAJUS. 3 [hp_X] in 1 mL. ... Carduus Marianus 3X, 30C, Chelidonium Majus 3X, 30C, Cina 3X, 30C, Sabadilla 3X, 30C, Teucrium Marum 3X, 30C, Terebinthina 5X, ... carduus marianus, chelidonium majus, cina, sabadilla, teucrium marum, terebinthina, thyroidinum (suis), spigelia anthelmia, ... Label: 10 PARASITE DETOX (carduus marianus, chelidonium majus, cina, sabadilla, teucrium marum, terebinthina, thyroidinum- suis ...
Lactarius chelidonium | Western Pennsylvania Mushroom Club
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Chelidonium (Cerambycidae) - Wikispecies
Genus: Chelidonium. Species: C. argentatum - C. binotaticolle - C. binotatum - C. bryanti - C. buddleiae - C. cheongae - C. ... Chelidonium - Taxon details on Biological Library (BioLib).. *Tavakilian, G. & Chevillotte, H.: TITAN: Cerambycidae database, ... Bemerkungen zur Gattung Chelidonium THOMSON, 1864, Teil 2 (Coleoptera: Cerambycidae: Callichromatini). Koleopterologische ... Retrieved from "https://species.wikimedia.org/w/index.php?title=Chelidonium_(Cerambycidae)&oldid=8570608" ...
Chelidonium majus "Laciniatum"
Chelidonium majus is native from Europe to Northern Africa and Asia. ... Chelidonium majus Laciniatum Common name(s): Greater Celandine, Tetterwort Synonyme(s): N/A Family: Papaveraceae Origin: none ... Chelidonium majus is native from Europe to Northern Africa and Asia.. *More infos: Chelidonium majus "Laciniatum" can be grown ...
Chelidonium Plex - Better Living
Chelidonium majus {Papaveraceae} Celandine
Hom opathikum: Chelidonium majus
Chelidonium majus - Michigan Flora
A native of Eurasia, sometimes a locally common weed of roadsides, dumps, railroads, forests, thickets, and gardens. First collected in 1890 in Kent Co.. The foliage is very similar to that of Stylophorum, but the cauline leaves are clearly alternate and the petals are distinctly smaller (ca. 8-14 mm long). A double-flowered form is sometimes cultivated and also escapes. The bitter sap of this plant, as of many other members of the family, has long been thought to be of medicinal value although fundamentally poisonous.. ...
Chelidonium majus | World of Flowering Plants
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Dr Reckeweg Chelidonium Majus Dilution 30C, 200C - Homeopathy Remedies Online
Chelidonium Majus therapeutic range of actions as per Boerick Materia Medica. A prominent liver remedy, covering many of the ... Home / German Remedies / Dr.Reckeweg Dilutions / Dr Reckeweg Chelidonium Majus Dilution 30C, 200C. View cart "Dr.Reckeweg R16 ... Be the first to review "Dr Reckeweg Chelidonium Majus Dilution 30C, 200C" Cancel reply. Your email address will not be ... Chelidonium Majus is diluted in various potencies namely 6C, 30C, 200C, 1M, 10M ...
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靈丹妙藥的同類療法》- EP113 - 白屈菜 Chelidonium Majus
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Does historical documentation support the proposed traditional use of Chelidonium majus L. by the European Medicines Agency? :...
Does historical documentation support the proposed traditional use of Chelidonium majus L. by the European Medicines Agency? ... Does historical documentation support the proposed traditional use of Chelidonium majus L. by the European Medicines Agency? ... Does historical documentation support the proposed traditional use of Chelidonium majus L. by the European Medicines Agency? ... ac.uk/item/q279x/does-historical-documentation-support-the-proposed-traditional-use-of-chelidonium-majus-l-by-the-european- ...
vla tovi n k v t - Chelidonium majus | Kv tena esk republiky - plan rostliny R | www.kvetenacr.cz
Jedovat rostlina, vyu v se ve farmacii, rovn v lidov m l itelstv , zde je ov em p i p ekro en doporu en ch d vek nebezpe n . Droga p sob sedativn a antibioticky. Vla tovi n k je zvl zn m t m, e jeho ml ko odstra uje bradavice. Obsahuje p es 30 alkaloid podobn ch opiov m, nejv ce jich je v ko eni. V minulosti m l nes etn mno stv lidov ch n zv . Semena obsahuj 40 60% technicky vyu iteln ho oleje.. Ochrana: ...