The effect of chelating agents on iron mobilization in Chang cell cultures. (1/3854)
The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3-dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells. They are effective to an approximately equal degree. The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound. How far these phenomena relate to therapeutic potentially remains to be seen. (+info)Highly sensitive quantitation of methamphetamine by time-resolved fluoroimmunoassay using a new europium chelate as a label. (2/3854)
A simple and highly sensitive time-resolved fluoroimmunoassay of methamphetamine (MA) using a new fluorescent europium chelate (BHHCT-Eu3+) as a label is described. Two variations of competitive immunoassay were attempted. In the first (one-step) assay, microtiter plates coated with anti-MA were used, and the new label was bound to a conjugate of bovine serum albumin and N-(4-aminobutyl)-MA (MA-BSA). In the second (two-step) assay, instead of the labeled MA-BSA, biotinylated MA-BSA and BHHCT-Eu3+-labeled streptavidin-BSA were used. The lowest measurable concentrations of MA for the one-step and the two-step methods were 1 ng/mL (25 pg/assay) and 1 pg/mL (25 fg/assay), respectively. These were 10 to 1000 times superior to the detection limits of MA in any other immunoassay. Intra-assay coefficient of variation was approximately 2-8% at eight different concentrations (n = 4). Analysis of 34 urine samples with the new method and conventional gas chromatography showed a good correlation (r = 0.954). The high detectability of the present assay also enabled segmental hair analysis with a few centimeters of a hair. (+info)Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. (3/3854)
Persistent potentiations of the chemical and electrotonic components of the eighth nerve (NVIII) EPSP recorded in vivo in the goldfish reticulospinal neuron, the Mauthner cell, can be evoked by afferent tetanization or local dendritic application of an endogenous transmitter, dopamine (3-hydroxytyramine). These modifications are attributable to the activation of distinct intracellular kinase cascades. Although dopamine-evoked potentiation (DEP) is mediated by the cAMP-dependent protein kinase (PKA), tetanization most likely activates a Ca2+-dependent protein kinase via an increased intracellular Ca2+ concentration. We present evidence that the eighth nerve tetanus that induces LTP does not act by triggering dopamine release, because it is evoked in the presence of a broad spectrum of dopamine antagonists. To test for interactions between these pathways, we applied the potentiating paradigms sequentially. When dopamine was applied first, tetanization produced additional potentiation of the mixed synaptic response, but when the sequence was reversed, DEP was occluded, indicating that the synapses potentiated by the two procedures belong to the same or overlapping populations. Experiments were conducted to determine interactions between the underlying regulatory mechanisms and the level of their convergence. Inhibiting PKA does not impede tetanus-induced LTP, and chelating postsynaptic Ca2+ with BAPTA does not block DEP, indicating that the initial steps of the induction processes are independent. Pharmacological and voltage-clamp analyses indicate that the two pathways converge on functional AMPA/kainate receptors for the chemically mediated EPSP and gap junctions for the electrotonic component or at intermediaries common to both pathways. A cellular model incorporating these interactions is proposed on the basis of differential modulation of synaptic responses via receptor-protein phosphorylation. (+info)Hereditary juvenile haemochromatosis: a genetically heterogeneous life-threatening iron-storage disease. (4/3854)
Juvenile haemochromatosis is a rare inborn error of iron metabolism with clinical manifestations before 30 years of age. Unlike adult haemochromatosis which principally affects men, juvenile haemochromatosis affects the sexes equally; it causes early endocrine failure, dilated cardiomyopathy and joint disease. We report four patients (two of each sex) from three pedigrees affected by juvenile haemochromatosis with a mean onset at 22 years (range 14-30). All had endocrine deficiency with postpubertal gonadal failure secondary to pituitary disease; two suffered near-fatal cardiomyopathy with heart failure. Mean time to diagnosis from the first clinical signs of disease was 9.8 years (range 0.5-20) but general health and parameters of iron storage responded favourably to iron-depletion therapy. A 24-year-old man listed for heart transplantation because of cardiomyopathy [left ventricular (LV) ejection fraction 16%] responded to intravenous iron chelation with desferrioxamine combined with phlebotomy (ejection fraction 31%). A 27-year-old woman with subacute biventricular heart failure refractory to medication required orthotopic cardiac transplantation before the diagnosis was established (LV ejection fraction 25%). Genetic studies showed that these two patients with cardiomyopathy from unrelated families were heterozygous for the HFE 845G-->A (C282Y) mutation and wild-type at the H63D locus: complete sequencing of the intron-exon boundaries and entire coding sequence of the HFE gene failed to identify additional lesions. Two siblings in a pedigree without cardiomyopathy were wild-type at the HFE C282Y locus; although the brother harboured a single copy of the 187C-->G (H63D) allele, segregation analysis showed that in neither sibling was the iron-storage disease linked to MHC Class I markers on chromosome 6p. Juvenile haemochromatosis is thus a genetically heterogenous disorder distinct from the common adult variant. (+info)Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution. (5/3854)
Monoclonal antibodies (MoAb) labeled with 90Y are being used for radioimmunotherapy. Because 90Y is a beta emitter, quantitative information from imaging is suboptimal. With the concept of a "matched pair" of isotopes, 111In is used as a surrogate markerfor90Y. We evaluated the differences in biodistribution between 111In- and 90Y-labeled murine antiTac MoAb directed against the IL-2Ralpha receptor. METHODS: The antiTac was conjugated to the 2-(4-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid (1B4M-DTPA, also known as MX-DTPA). Nine patients with adult T-cell leukemia were treated. Patients received approximately 185 MBq (5 mCi) 111In-labeled antiTac for imaging and 185-555 MBq (5-15 mCi) 90Y-labeled antiTac for therapy. The immunoreactivity of 111In-labeled antiTac was 90%+/-6%, whereas for 90Y-labeled antiTac, it was 74%+/-12%. RESULTS: The differences in blood and plasma kinetics of the two isotopes were small. The area undemeath the blood radioactivity curve was 1.91 percentage+/-0.58 percentage injected dose (%ID) x h/mL for 111In and 1.86%+/-0.64 %ID x h/mL for 90Y. Urinary excretion of 90Y was significantly greater than that of 111In in the first 24 h (P = 0.001), but later, the excretion of 111In was significantly greater (P = 0.001 to P = 0.04). Core biopsies of bone marrow showed a mean of 0.0029+/-0.0012 %ID/g for 111In, whereas the 90Y concentration was 0.0049+/-0.0021 %ID/g. Analyses of activity bound to circulating cells showed concentrations of 500-30,000 molecules of antiTac per cell. When cell-bound activity was corrected for immunoreactive fraction, the ratio of 111In to 90Y in circulating cells was 1.11+/-0.17. Three biopsies of tumor-involved skin showed ratios of 111In to 90Y of 0.7, 0.9 and 1.1. CONCLUSION: This study shows that differences typically ranging from 10% to 15% exist in the biodistribution between 111In- and 90Y-labeled antiTac. Thus, it appears that 111In can be used as a surrogate marker for 90Y when labeling antiTac with the 1 B4M chelate, although underestimates of the bone marrow radiation dose should be anticipated. (+info)Augmentation is a potentiation of the exocytotic process. (6/3854)
Short-term synaptic enhancement is caused by an increase in the probability with which synaptic terminals release transmitter in response to presynaptic action potentials. Since exocytosed vesicles are drawn from a readily releasable pool of packaged transmitter, enhancement must result either from an increase in the size of the pool or an elevation in the fraction of releasable vesicles that undergoes exocytosis with each action potential. We show here that at least one major component of enhancement, augmentation, is not caused by an increase in the size of the readily releasable pool but is instead associated with an increase in the efficiency with which action potentials induce the exocytosis of readily releasable vesicles. (+info)Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections. (7/3854)
Marrow cells from mice lacking high-affinity receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF; betac-/- mice) were shown to bind and internalize much less GM-CSF than cells from normal (betac+/+) mice. betac-/- mice were used to determine the effect of negligible receptor-mediated clearance on detectible GM-CSF responses to the intravenous injection of endotoxin or the intraperitoneal injection of casein plus microorganisms. Unlike the minor serum GM-CSF responses to endotoxin seen in betac+/+ mice, serum GM-CSF levels rose 30-fold to 9 ng/mL in betac-/- mice even though loss of GM-CSF in the urine was greater than in betac+/+ mice. Organs from betac-/- and betac+/+ mice had a similar capacity to produce GM-CSF in vitro, as did peritoneal cells from both types of mice when challenged in vitro by casein. However, when casein was injected intraperitoneally, betac-/- mice developed higher and more sustained levels of GM-CSF than did betac+/+ mice. The data indicated that receptor-dependent removal of GM-CSF masks the magnitude of GM-CSF responses to endotoxin and local infections. Because of this phenomenon, serum GM-CSF concentrations can be a misleading index of the occurrence or nonoccurrence of GM-CSF responses to infections. (+info)Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation. (8/3854)
Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca2+]i). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca2+]i elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca2+]i with relatively high magnitude, which mimics the [Ca2+]i rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca2+]i reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information. (+info)
Transition metal porphyrin complexes
Biomolecules, Chelating agents, Porphyrins). ...
Bipyridine
... s, Chelating agents, Ligands). ... 2,2′-Bipyridine (2,2′-bipy) is a chelating ligand that forms ...
Corrole
Chelating agents, Tetrapyrroles, Macrocycles). ... and nitrido transfer agents, and as catalysts for the catalytic ... Additionally, corroles and their metal complexes have been demonstrated to be useful as imaging agents in tumor detection, ...
Aminopolycarboxylic acid
Equilibrium chemistry, Chelating agents). ... The chelating properties of aminopolycarboxylates can be ...
MACHO catalyst
Homogeneous catalysis, Chelating agents, Diphosphines). ...
1,5-Diaza-3,7-diphosphacyclooctanes
Chelating agents, Diphosphines, Phosphorus heterocycles). ...
Phosphonate
... chelating agent EDTMP: Ethylenediaminetetra(methylenephosphonic acid), chelating agent TDTMP: Tetramethylenediaminetetra( ... methylenephosphonic acid), chelating agent HDTMP: Hexamethylenediaminetetra(methylenephosphonic acid), chelating agent DTPMP: ... Phosphonates are effective chelating agents. That is, they bind tightly to di- and trivalent metal ions, which is useful in ... In detergents they are used as a combination of chelating agent, scale inhibitor, and bleach stabilizer. Phosphonates are also ...
Chelation therapy
The chelating agent may be administered intravenously, intramuscularly, or orally, depending on the agent and the type of ... Other chelating agents have been discovered. They all function by making several chemical bonds with metal ions, thus rendering ... Other chelating agents, such as 2,3-dimercaptopropanesulfonic acid (DMPS) and alpha lipoic acid (ALA), are used in conventional ... Research in the former Soviet Union led to the introduction of DMPS, another dithiol, as a mercury-chelating agent. The Soviets ...
Hexadentate ligand
Lions, F. (1961). "The design of multidentate chelating agents". Record of Chemical Progress. 22: 69-78. ISSN 0034-1584. PMID ...
Ethylenediaminetetraacetic acid
In tissue culture EDTA is used as a chelating agent that binds to calcium and prevents joining of cadherins between cells, ... Candidate chelating agents include nitrilotriacetic acid (NTA), iminodisuccinic acid (IDS), polyaspartic acid, S,S- ... "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... chelating agent. Many of the resulting coordination compounds adopt octahedral geometry. Although of little consequence for its ...
Tetrasodium EDTA
It is used as a source of the chelating agent EDTA4-. A 1% aqueous solution has a pH of approximately 11.3. When dissolved in ... It is sometimes used as a chelating agent. The assignee on 5% of patents at the USPTO containing the substance is the firm ... "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... Zaitoun, Mohammed A.; Lin, C. T. (1997). "Chelating Behavior between Metal Ions and EDTA in Sol−Gel Matrix". The Journal of ...
Metalloprotease inhibitor
Most MMP inhibitors are chelating agents. The inhibitor binds to the zinc at the active center of the enzyme, thereby blocking ... One is a chelating moiety that interacts with the zinc ion and the other is a hydrophobic extension from the catalytic site ... In vitro, EDTA, 1,10-phenanthroline and other chelating compounds lower the concentration of metal to the point where the metal ... It is an antitumor and antiangiogenic agent with oral bioavailability. Inhibition of TACE and MMP-1 are linked to the ...
Glycine
Hart, J. Roger (2005). "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial ... It serves as a buffering agent, maintaining pH and preventing sample damage during electrophoresis. Glycine is also used to ... as an agent in metal complexing and finishing. Glycine is not widely used in foods for its nutritional value, except in ...
Chelation
These ligands are called chelants, chelators, chelating agents, or sequestering agents. They are usually organic compounds, but ... Chelating agents convert these metal ions into a chemically and biochemically inert form that can be excreted. Chelation using ... Such chelating agents include the porphyrin rings in hemoglobin and chlorophyll. Many microbial species produce water-soluble ... EDTA is the typical chelating agent that keeps these metal ions in a soluble form. Dechelation (or de-chelation) is a reverse ...
Malaria
There is insufficient evidence that iron chelating agents such as deferoxamine and deferiprone improve outcomes of those with ... Cochrane Infectious Diseases Group) (2003-04-22). "Iron chelating agents for treating malaria". The Cochrane Database of ... There is insufficient data on whether osmotic agents such as mannitol or urea are effective in treating cerebral malaria. ... Biot C, Castro W, Botté CY, Navarro M (2012). "The therapeutic potential of metal-based antimalarial agents: Implications for ...
Lead poisoning
A chelating agent is a molecule with at least two negatively charged groups that allow it to form complexes with metal ions ... Chelating agents can have adverse effects; for example, chelation therapy can lower the body's levels of necessary nutrients ... Chelating agents taken orally can increase the body's absorption of lead through the intestine. Chelation challenge, also known ... The chelating agents used for treatment of lead poisoning are edetate disodium calcium (CaNa2EDTA), dimercaprol (BAL), which ...
H. Vasken Aposhian
... chelating agent 2,3-dimercapto-1-propanesulfonic acid. This method however has been proven[citation needed] to provide ... the human metabolism of chelating agents; and biochemical genetics in particular gene transfer in mammalian cells. Aposhian has ...
Metal dithiolene complex
Coordination complexes, Thiols, Chelating agents, Coordination chemistry). ...
Pendetide
Chelating agents, Chelating agents used as drugs, Carboxylic acids, Peptides, All stub articles, Pharmacology stubs). ... Pendetide (GYK-DTPA) is a chelating agent. It consists of pentetic acid (DTPA) linked to the tripeptide glycine (G) - L- ...
Geyser
"Enzymes and chelating agent in cotton pretreatment". Journal of Biotechnology. 89 (2-3): 271-279. doi:10.1016/S0168-1656(01) ...
Ethylenediamine
A most prominent derivative of ethylenediamine is the chelating agent EDTA, which is derived from ethylenediamine via a ... Hydroxyethylethylenediamine is another commercially significant chelating agent. Numerous bio-active compounds and drugs ... Chelating agents, Fuel antioxidants, Corrosion inhibitors, Commodity chemicals, Ethyleneamines, Foul-smelling chemicals, ... The derivative N,N-ethylenebis(stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline ...
Radium-223
Henriksen G, Hoff P, Larsen RH (May 2002). "Evaluation of potential chelating agents for radium". Applied Radiation and ...
Alkali soil
The effect of chelating agents on soil sodicity. Soil and Sediment Contamination 16: 301-312. Farooq Ahmad. "Karnal / Kallar ... In viticulture, adding naturally occurring chelating agents such as tartaric acid to irrigation water has been suggested, to ...
Generalized arterial calcification of infancy
Sodium Thiosulfate (STS) is a calcium-chelating agent. It is typically used by patients who have excess calcium in their ...
Lewis acids and bases
These multidentate Lewis bases are called chelating agents. Lewis acids and bases are commonly classified according to their ...
Podsolisation
... mor humus is produced which provides a greater amount of chelating agents. In podsolisation, chelating agents break down clay ... These organic acids are known as chelating agents. Many podsol soils form underneath coniferous forests, the fact that pine ...
Gadolinium(III) chloride
One representative chelating agent is H5DTPA, diethylenetriaminepentaacetic acid. Chelation to the conjugate base of this ... "Free" gadolinium(III), e.g. [GdCl2(H2O)6]+, is toxic, so chelating agents are essential for biomedical applications. Simple ... GdCl3∙6H2O can not be used as an MRI contrasting agent due to its low solubility in water at the body's near neutral pH. " ... To generate the relaxation agents, Gd3+ sources such as GdCl3∙6H2O are converted to coordination complexes. ...
Neocuproine
... is a heterocyclic organic compound and chelating agent. Phenanthroline ligands were first published in the late ...
Ionophore
Iron ionophores and chelating agents are collectively called siderophores. Many synthetic ionophores are based on crown ethers ... It also serves as an anti-fouling agent in paints to cover and protect surfaces against mildew and algae. Clioquinol and PBT2 ... It is also used as a food additive, shelf-life extending agent in food packaging, and wood preservative in timber treatment. ... "Chapter 76:Antifungal Agents". Medical microbiology (4th ed.). Galveston, Tex.: University of Texas Medical Branch at Galveston ...
Bispidine
It has been widely investigated as a chelating agent. Many derivatives are known. Bispidine has a bicyclic scaffold consisting ...
List of food additives
Chelating Agent Egg - Egg yolk - Egg white - Elderberry - Eleutherococcus senticosus - Enzymatically hydrolyzed Carboxymethyl ... Flour treatment agents Flour treatment agents are added to flour to improve its color or its use in baking. Glazing agents ... Anticaking agents Anticaking agents keep powders such as milk powder from caking or sticking. Antifoaming agents Antifoaming ... anti-caking agent, firming agent Calcium polyphosphates - anti-caking agent Calcium propionate - preservative Calcium salts of ...
New Delhi metallo-beta-lactamase 1
Indian studies have been done which demonstrate their dependency on zinc and the ability of zinc chelating agents like EDTA to ... Antimicrob Agents Chemother. 53 (12): 5046-5054. doi:10.1128/AAC.00774-09. PMC 2786356. PMID 19770275. Deshpande Payal; ...
2-Chloromethylpyridine
Rapko, B. M.; Duesler, E. N.; Smith, P. H.; Paine, R. T.; Ryan, R. R. (1993). "Chelating Properties of 2-((Diphenylphosphino) ... It is an alkylating agent. 2-Chloromethylpyridine is a precursor to pyridine-containing ligands. 2-Chloromethylpyridine is an ... Alkylating agents, Organochlorides, 2-Pyridyl compounds, IARC Group 1 carcinogens). ...
Iron overload
Medication: For those unable to tolerate routine blood draws, there are chelating agents available for use. The drug ... Two newer iron-chelating drugs that are licensed for use in patients receiving regular blood transfusions to treat thalassaemia ... "Chelating Polymers for Hereditary Hemochromatosis Treatment". Macromolecular Bioscience. 20 (12): 2000254. doi:10.1002/mabi. ...
Jan Aaseth
Protective measures include the therapeutic use of new iron chelating agents, which have been studied by Aaseth and co-workers ... Analyst, 123(1), 3-6. Aaseth J (1983). Recent advance in the therapy of metal poisonings with chelating agents. Human ... Some of these agents appear to protect against cardiovascular complication. Jan Aaseth has since the 1970s been interested in ... Aaseth has studies the effects of disease-modifying agents including anti-TNF-alpha drugs and also selenium compounds. ...
Porphyrin
Chelating agents, Porphyrins). ... have been investigated as possible anti-inflammatory agents and ...
Cavitand
Articles with short description, Short description is different from Wikidata, Supramolecular chemistry, Chelating agents). ...
2,4,6-Heptanetrione
Chelating agents, Ligands, 3-Hydroxypropenals, Enols, Tridentate ligands). ...
Binding selectivity
The further use of quantitative structure-activity relationships (QSAR) led to the development of other agents such as ... Chelation therapy is a form of medical treatment in which a chelating ligand is used to selectively remove a metal from the ... occurring siderophore produced by the actinobacter Streptomyces pilosus and was used initially as a chelation therapy agent. ...
Sodium calcium edetate
... is in the chelating agent family of medication. It is a salt of edetate with two sodium and one calcium ... Chelating agents used as drugs, Organic sodium salts, World Health Organization essential medicines). ...
Aceruloplasminemia
Treatment includes the use of iron chelating agents (such as desferrioxamine) to lower brain and liver iron stores, and to ...
Dithiooxamide
It acts as a chelating agent, e.g. in the detection or determination of copper. It has also been used as a building block in ...
2,3-Dimercapto-1-propanesulfonic acid
... are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating ... pharmacological and toxicological properties of an orally effective metal chelating agent". Annual Review of Pharmacology and ... agent. The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. The effects of DMPS on heavy metal poisoning, ...
Catechol
Chelating agents, Enediols, IARC Group 2B carcinogens, Photographic chemicals, Reducing agents). ... urushiols, the active agent in poison ivy (R = (CH2)14CH3, (CH2)7CH=CHCH2CH=CHCH2CH=CH2, and others) catecholamines, drugs ...
1,10-Phenanthroline
Chelating agents, Phenanthrolines). ... and an oxidizing agent, traditionally aqueous arsenic acid or ...
Organolanthanide chemistry
If a chelating agent (L-L), such as tetramethylethylenediamine (tmed or tmeda) or 1,2-dimethoxyethane (dme) is mixed with MCl3 ...
EGTA (chemical)
... a chelating agent. It is a white solid that is related to the better known EDTA. Compared to EDTA, it has a lower affinity for ...
BDTH2
The compound was reported in about 1994 after a search for chelating agents selective for mercury. It was licensed in 2006 to ... is an organosulfur compound that is used as a chelation agent. It is a colourless solid. The molecule consists of two thiol ... "Low-level mercury removal from groundwater using a synthetic chelating ligand". Water Res. 42 (8-9): 2025-8. doi:10.1016/j. ... Low-level mercury removal from groundwater using a synthetic chelating ligand, Water Research, Vol. 42, Issues 8-9, April 2008 ...
Paint stripper
Sequestrants and chelating agents are used to "disarm" metal ions present in the solution, which could otherwise reduce the ... Cellulose-based agents, e.g., hydroxypropyl cellulose, are commonly used for mixtures that are not extremely acidic or basic; ...
Chlorquinaldol
... is an antimicrobial agent and antiseptic. It is a chlorinated derivative of the popular chelating agent 8- ... Antiprotozoal agents, Antiseptics, Chloroarenes, Quinolinols, All stub articles, Antiinfective agent stubs, Genito-urinary ... Agents Chemother. 26 (1): 35-8. doi:10.1128/aac.26.1.35. PMC 179912. PMID 6236746. Kutscher, Bernhard (2020). "Dermatologicals ...
Tetraacetylethane
Chelating agents, Ligands, 3-Hydroxypropenals). ...
ADA (buffer)
ADA has been used in protein-free media for chicken embryo fibroblasts, as a chelating agent for H+, Ca2+, and Mg2+, and for ... ADA is a zwitterionic organic chemical buffering agent; one of Good's buffers. It has a useful pH range of 6.0-7.2 in the ...
DOTA (chelator)
The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for ... Moi, Min K.; Claude F. Meares; Sally J. DeNardo (1988). "The peptide way to macrocyclic bifunctional chelating agents: ... DOTA is used as a complexing agent, especially for lanthanide ions. Its complexes have medical applications as contrast agents ... Chelating agents, Octadentate ligands, Substances discovered in the 1970s, DOTA (chelator) derivatives). ...
Sodium acetylacetonate
Chelating agents, Ligands, 3-Hydroxypropenals). ...
Glucosepane
However, an alternate hypothesis as to how they work is that they act as chelating agents. Two thiazolium molecules, PTB (N- ... 1996). "An agent cleaving glucose-derived protein crosslinks in vitro and in vivo". Nature. nature publishing group. 382 (6588 ... 1996). "An agent cleaving glucose-derived protein crosslinks in vitro and in vivo". Nature. nature publishing group. 382 (6588 ... is a persisting glycating agent because it is irreversibly bound through lysine to a protein. Therefore, it is not easily ...
Chelex 100
Official site (CS1 maint: multiple names: authors list, Chelating agents). ... Chelex 100 is a chelating material from Bio-Rad used to purify other compounds via ion exchange. It is noteworthy for its ... "Chelex® 100 and Chelex 20 Chelating Ion Exchange Resin Instruction Manual" (PDF). Walsh, P.S., Metzger D.A., and Higuchi, R. ( ... R. N. Ceo; M. R. Kazerouni; K. Rengan (1993). "Sorption of silver ions by Chelex 100 chelating resin". Journal of ...
BAPTA
Chelating agents, Phenol ethers, Glycol ethers). ...
Organosodium chemistry
When the organic substituents are bulky and especially in the presence of chelating ligands like TMEDA, the derivatives are ... which is used as a soluble reducing agent: C10H8 + Na → Na+[C10H8]−• Structural studies show however that sodium naphthalene ...
Chelating Agents - PubMed
Chelating agents are generally classified based upon the target heavy metal - iron, copper, mercury and lead being the major ... Some chelating agents have a high degree of specificity for the target metal, w … ... Chelating agents are used to reduce blood and tissue levels of injurious heavy metals. ... Chelating agents are used to reduce blood and tissue levels of injurious heavy metals. Chelating agents are generally ...
Acute iron poisoning in children: role of chelating agents - PubMed
Acute iron poisoning in children: role of chelating agents D G Barr et al. Br Med J. 1968. . ... Clinical usefulness of iron chelating agents. Waxman HS, Brown EB. Waxman HS, et al. Prog Hematol. 1969;6:338-73. Prog Hematol ... Acute iron poisoning in children: role of chelating agents D G Barr, D K Fraser ... Iron-chelating treatment]. Vullo C, Di Palma A, De Sanctis V, Borgatti L, Atti G. Vullo C, et al. Haematologica. 1989 Oct;74(5 ...
ICD-10 Code for Poisoning by antidotes and chelating agents, accidental (unintentional), subsequent encounter- T50.6X1D- Codify...
ICD-10 code T50.6X1D for Poisoning by antidotes and chelating agents, accidental (unintentional), subsequent encounter is a ... ICD-10-CM Code for Poisoning by antidotes and chelating agents, accidental (unintentional), subsequent encounter T50.6X1D ICD- ... 10 code T50.6X1D for Poisoning by antidotes and chelating agents, accidental (unintentional), subsequent encounter is a medical ...
Water softening - Wikipedia
Wilson Disease - All Content - NIDDK
Chelating agents may interfere with wound healing, and doctors may prescribe a lower dose of chelating agents for people who ... Chelating agents. Penicillamine (Cupramine, Depen) and trientine (Syprine) are two chelating agents used to treat Wilson ... When treatment begins, doctors gradually increase the dose of chelating agents. People take higher doses of chelating agents ... Doctors may prescribe a lower dose of chelating agents for women who are pregnant. Since the fetus needs a small amount of ...
Sequestering Agents | Chelating Agents Manufacturers & Exporters in India
Chelating Agents and other Pretreatment Chemicals in India. ... Sequestering Agents. PRODUCT NAME Sequel 100 A. An excellent ... recognized as a Star Export House are of Indias leading manufacturers and exporters of Sequestering Agents, ... They are also known as anti-redeposition agents or anti-soil redeposition agents. The functions of dispersant polymers for ... Dispersant polymers are used in institutional cleaners, such as industrial and commercial cleaning agents, to improve the ...
Chelating agent vs ethyl Lauroyl Arginate HCl - Formulating - Chemists Corner
Preventing Lead Poisoning in Young Children
PHARMACOLOGY OF CHELATING AGENTS. BAL. CaNa2EDTA. D-PENICILLAMINE. SUCCIMER. TREATMENT GUIDELINES FOR CHILDREN WITH BLOOD LEAD ... EFFICACY OF CHELATING AGENTS. SUCCIMER. TOXICITY OF CaNa2EDTA. REFERENCES. CHAPTER 8. MANAGEMENT OF LEAD HAZARDS IN THE ... PHARMACOLOGY OF CHELATING AGENTS. Table 7 1 Several drugs are used in the treatment of lead poisoning. These drugs, capable of ... PHARMACOLOGY OF CHELATING AGENTS. TREATMENT GUIDELINES FOR CHILDREN WITH BLOOD LEAD LEVELS , OR = 20 UG/DL.. POST-CHELATION ...
EWG Skin Deep® | Honest Baby Wipes Rating
chelating agent, fragrance ingredient, ph adjuster, buffering, chelating, masking. CONCERNS. • Use restrictions (meets ... oral care agent;oral health care drug, skin-conditioning agent - humectant, skin protectant, viscosity decreasing agent, ... deodorant agent, skin-conditioning agent - miscellaneous, skin conditioning. CONCERNS. • Allergies/immunotoxicity (low). • Non- ... skin-conditioning agent - emollient, skin-conditioning agent - miscellaneous, emollient, skin conditioning. LEARN MORE ABOUT ...
DailyMed - REBLOZYL- luspatercept injection, powder, lyophilized, for solution
Effect of Iron-chelating Agents on Luspatercept-aamt No clinically significant differences in luspatercept-aamt PK were ... All patients were eligible to receive best supportive care, which included RBC transfusions; iron-chelating agents; use of ... REBLOZYL is an erythroid maturation agent indicated for the treatment of: •. Anemia in adult patients with beta thalassemia who ... The data in the WARNINGS AND PRECAUTIONS reflect exposure to REBLOZYL as a single agent administered across a range of doses ( ...
Meguiars Product Ingredients | Meguiar's
Colour Enablers | Schwarzkopf Professional
Steam iron cleaner poisoning: MedlinePlus Medical Encyclopedia
Windy Boyd, Ph.D., M.P.H. - Senior Science Editor
ICD-10-CM/PCS MS-DRG v37.0 Definitions Manual
Underdosing of antidotes and chelating agents, initial encounter. T507X6A. Underdosing of analeptics and opioid receptor ... Underdosing of antivaricose drugs, including sclerosing agents, initial encounter. T46906A. Underdosing of unspecified agents ... Underdosing of other agents primarily affecting the cardiovascular system, initial encounter. T470X6A. Underdosing of histamine ... Underdosing of unspecified agents primarily affecting the gastrointestinal system, initial encounter. T480X6A. Underdosing of ...
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Dermatologic Manifestations of Gastrointestinal Disease: Overview, Dermatology and the Pharynx, Dermatology and the Esophagus
Treatment of these patients with phlebotomy or chelating agents results in a decrease in skin pigmentation over time. ... 17] Amongst the agents that attain a 30% response rate are interferons, antiviral agents (eg, zidovudine), cytotoxic agents (eg ... Primary treatment involves phlebotomy and chelating agents, with conventional management of hepatic failure should this ... Psoriasiform Skin Lesions Are Caused by Anti-TNF Agents Used for the Treatment of Inflammatory Bowel Disease. Dig Dis Sci. 2015 ...
Arsenic | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Water-soluble chelating agents like DMSA are less toxic than BAL and are often substituted when the patients condition ... The use of D-penicillamine as an oral chelating agent is controversial. It has been used successfully in children, but should ... In severe cases, medicines called chelating agents are given to remove arsenic from the body and eliminate it in the urine. ... Cardiac sensitizing agents may be appropriate; however, the use of cardiac sensitizing agents after exposure to certain ...
DeCS 2017 - December 21, 2017 version
content/basf/www/ie/en/who-we-are/sustainability/whats-new/sustainability-news/2019/trilon-m-max-based-on-renewable-resources
Chelating agents are used in a huge variety of applications. In modern dishwasher tabs, chelating agents prevent and dissolve ... Chelating agents are also used as intermediates in the production of specialized fertilizers which can add to plant health and ... We developed the readily biodegradable chelating agent Trilon M in the first place because we realized early on how important ...
Publication Detail
Increasing Incidence of Zygomycosis (Mucormycosis), France, 1997-2006 - Volume 15, Number 9-September 2009 - Emerging...
The clinical contribution of new iron chelating agents remains controversial (14,15). ... Soummer A, Mathonnet A, Scatton O, Massault PP, Paugam A, Lemiale V, Failure of deferasirox, an iron chelator agent, combined ... Most triazole agents are not effective in vivo (10), except for posaconazole, which shows some efficacy both experimentally and ... Activity of posaconazole in treatment of experimental disseminated zygomycosis. Antimicrob Agents Chemother. 2003;47:3647-50. ...
DailyMed - BUSULFAN injection
Discontinue iron chelating agents well in advance of administration of busulfan to avoid increased exposure to busulfan. ... Drugs that Decrease Busulfan Clearance: Metronidazole, itraconazole, iron chelating agents, acetaminophen. (7.1) ... Busulfan is a bifunctional alkylating agent in which two labile methanesulfonate groups are attached to opposite ends of a four ... Busulfan is a bifunctional alkylating agent known chemically as 1,4-butanediol, dimethanesulfonate. The molecular formula of ...
Penicillamine2
Deferoxamine1
- The iron chelating agents currently in use include deferoxamine, deferasirox and deferiprone, all of which are highly specific for iron and have little or no effect on levels of copper, lead, calcium, magnesium or phosphate. (nih.gov)
Copper8
- Chelating agents are generally classified based upon the target heavy metal - iron, copper, mercury and lead being the major targets. (nih.gov)
- These agents are used largely to treat Wilson disease, the complications of which are caused by excessive body copper accumulation. (nih.gov)
- People take higher doses of chelating agents until the extra copper in the body has been removed. (nih.gov)
- When Wilson disease symptoms have improved and tests show that copper is at safe levels, doctors may prescribe lower doses of chelating agents as maintenance treatment. (nih.gov)
- Doctors may prescribe zinc as a maintenance treatment, after chelating agents have removed extra copper from the body. (nih.gov)
- 4. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. (nih.gov)
- 6. Overcoming platinum drug resistance with copper-lowering agents. (nih.gov)
- 8. Mechanistic basis for overcoming platinum resistance using copper chelating agents. (nih.gov)
Citric1
- some release agents include vitamin E and citric acid. (ift.org)
Additive1
- Compatibility with other cleaning agents: Dispersant polymers are typically compatible with a wide range of other cleaning agents, making them a versatile and effective additive for institutional cleaners. (fineotex.com)
Poisoning2
Iron chelat1
- Haemosiderosis, which plays a considerable function in thalassaemia patients before and role in early mortality, can be prevented or after treatment with high-dose deferoxam- postponed by iron-chelating agents which ine. (who.int)
Specificity1
- Some chelating agents have a high degree of specificity for the target metal, while others chelate multiple agents. (nih.gov)
Polymers2
- Dispersant polymers are used in institutional cleaners, such as industrial and commercial cleaning agents, to improve the cleaning performance and prevent soil re-deposition. (fineotex.com)
- Improved cleaning efficiency: Dispersant polymers can improve the efficiency of cleaning agents by helping to disperse soils and improve the cleaning solution's wetting ability. (fineotex.com)
Treatment2
- When treatment begins, doctors gradually increase the dose of chelating agents. (nih.gov)
- REBLOZYL is indicated for the treatment of anemia failing an erythropoiesis stimulating agent and requiring 2 or more red blood cell units over 8 weeks in adult patients with very low- to intermediate-risk myelodysplastic syndromes with ring sideroblasts (MDS-RS) or with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T). (nih.gov)
Chelation2
- Consistent with this authority, the NIAID is announcing a new grant initiative focused on the development of novel radionuclide chelation and decorporation agents. (nih.gov)
- In FY 2006, the NIAID intends to commit up to $4 million to support research projects focused on the development of novel radionuclide chelation and decorporation agents. (nih.gov)
Include1
- Other approaches include precipitation methods and sequestration by the addition of chelating agents. (wikipedia.org)
Prevent1
- In modern dishwasher tabs, chelating agents prevent and dissolve scales and dirt on dishes. (basf.com)
FUNCTION1
- Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS . (nih.gov)
Levels1
- Chelating agents are used to reduce blood and tissue levels of injurious heavy metals. (nih.gov)
Food1
- The patent was assigned to Viskase Corp. Claims describe the package as a film, such as a polymeric film or a regenerated cellulosic film, containing a heat-resistant, Pediococcus -derived bacteriocin in a synergistic combination with a chelating agent to inhibit or kill Listeria monocytogenes on contact with a food. (ift.org)
Applications1
- Chelating agents are used in a huge variety of applications. (basf.com)
Succimer2
- Succimer is a metal chelating agent, an analog of dimercaprol, and is used in lead poisoning. (medscape.com)
- Succimer is a chelating agent-a substance that can bind particular ions and remove them from solution. (nih.gov)
Cadmium1
- These agents are also used for arsenic, mercury and cadmium poisoning. (nih.gov)
Dimercaprol1
- The copper chelating agents in current use include penicillamine, trientine and dimercaprol. (nih.gov)
Intravenous1
- Children should never receive edetate disodium (Na2EDTA) as an intravenous chelating agent. (cdc.gov)
Acute2
- For acute allergic interstitial nephritis, if no spontaneous recovery in renal function is observed after cessation of the offending agent, implementing a short course of steroid therapy is generally recommended. (medscape.com)
- The chelating agents are rare causes of liver injury, the only agent convincingly linked to causing idiosyncratic acute liver injury with jaundice being penicillamine which usually causes of an immunoallergic, mostly cholestatic hepatitis with a short incubation period. (nih.gov)
Clinical1
- Clinical usefulness of iron chelating agents. (nih.gov)
Iron4
- Chelating agents are generally classified based upon the target heavy metal - iron, copper, mercury and lead being the major targets. (nih.gov)
- Iron-chelating treatment]. (nih.gov)
- Haemosiderosis, which plays a considerable function in thalassaemia patients before and role in early mortality, can be prevented or after treatment with high-dose deferoxam- postponed by iron-chelating agents which ine. (who.int)
- 1200 used iron-chelating agent. (who.int)
Metal1
- Recent advance in the therapy of metal poisoning with complexing agents]. (nih.gov)
Children1
- The 2 children had received edetate disodium (Na2EDTA) instead of edetate calcium disodium (CaEDTA), the appropriate agent. (cdc.gov)
Reduce2
- Extended therapy with this agent to reduce body lead stores may be of possible benefit. (medscape.com)
- Chelating agents are used to reduce blood and tissue levels of injurious heavy metals. (nih.gov)
Lead1
- These agents promote the excretion of lead. (medscape.com)
Effective1
- also increased in the population of patients with diabetes Most triazole agents are not effective in vivo ( 10 ), except mel itus. (cdc.gov)
Patients1
- Anemia failing an erythropoiesis stimulating agent and requiring 2 or more RBC units over 8 weeks in adult patients with very low- to intermediate-risk myelodysplastic syndromes with ring sideroblasts (MDS-RS) or with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) ( 1.2 ). (nih.gov)