The effect of chelating agents on iron mobilization in Chang cell cultures. (1/3854)

The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3-dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells. They are effective to an approximately equal degree. The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound. How far these phenomena relate to therapeutic potentially remains to be seen.  (+info)

Highly sensitive quantitation of methamphetamine by time-resolved fluoroimmunoassay using a new europium chelate as a label. (2/3854)

A simple and highly sensitive time-resolved fluoroimmunoassay of methamphetamine (MA) using a new fluorescent europium chelate (BHHCT-Eu3+) as a label is described. Two variations of competitive immunoassay were attempted. In the first (one-step) assay, microtiter plates coated with anti-MA were used, and the new label was bound to a conjugate of bovine serum albumin and N-(4-aminobutyl)-MA (MA-BSA). In the second (two-step) assay, instead of the labeled MA-BSA, biotinylated MA-BSA and BHHCT-Eu3+-labeled streptavidin-BSA were used. The lowest measurable concentrations of MA for the one-step and the two-step methods were 1 ng/mL (25 pg/assay) and 1 pg/mL (25 fg/assay), respectively. These were 10 to 1000 times superior to the detection limits of MA in any other immunoassay. Intra-assay coefficient of variation was approximately 2-8% at eight different concentrations (n = 4). Analysis of 34 urine samples with the new method and conventional gas chromatography showed a good correlation (r = 0.954). The high detectability of the present assay also enabled segmental hair analysis with a few centimeters of a hair.  (+info)

Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. (3/3854)

Persistent potentiations of the chemical and electrotonic components of the eighth nerve (NVIII) EPSP recorded in vivo in the goldfish reticulospinal neuron, the Mauthner cell, can be evoked by afferent tetanization or local dendritic application of an endogenous transmitter, dopamine (3-hydroxytyramine). These modifications are attributable to the activation of distinct intracellular kinase cascades. Although dopamine-evoked potentiation (DEP) is mediated by the cAMP-dependent protein kinase (PKA), tetanization most likely activates a Ca2+-dependent protein kinase via an increased intracellular Ca2+ concentration. We present evidence that the eighth nerve tetanus that induces LTP does not act by triggering dopamine release, because it is evoked in the presence of a broad spectrum of dopamine antagonists. To test for interactions between these pathways, we applied the potentiating paradigms sequentially. When dopamine was applied first, tetanization produced additional potentiation of the mixed synaptic response, but when the sequence was reversed, DEP was occluded, indicating that the synapses potentiated by the two procedures belong to the same or overlapping populations. Experiments were conducted to determine interactions between the underlying regulatory mechanisms and the level of their convergence. Inhibiting PKA does not impede tetanus-induced LTP, and chelating postsynaptic Ca2+ with BAPTA does not block DEP, indicating that the initial steps of the induction processes are independent. Pharmacological and voltage-clamp analyses indicate that the two pathways converge on functional AMPA/kainate receptors for the chemically mediated EPSP and gap junctions for the electrotonic component or at intermediaries common to both pathways. A cellular model incorporating these interactions is proposed on the basis of differential modulation of synaptic responses via receptor-protein phosphorylation.  (+info)

Hereditary juvenile haemochromatosis: a genetically heterogeneous life-threatening iron-storage disease. (4/3854)

Juvenile haemochromatosis is a rare inborn error of iron metabolism with clinical manifestations before 30 years of age. Unlike adult haemochromatosis which principally affects men, juvenile haemochromatosis affects the sexes equally; it causes early endocrine failure, dilated cardiomyopathy and joint disease. We report four patients (two of each sex) from three pedigrees affected by juvenile haemochromatosis with a mean onset at 22 years (range 14-30). All had endocrine deficiency with postpubertal gonadal failure secondary to pituitary disease; two suffered near-fatal cardiomyopathy with heart failure. Mean time to diagnosis from the first clinical signs of disease was 9.8 years (range 0.5-20) but general health and parameters of iron storage responded favourably to iron-depletion therapy. A 24-year-old man listed for heart transplantation because of cardiomyopathy [left ventricular (LV) ejection fraction 16%] responded to intravenous iron chelation with desferrioxamine combined with phlebotomy (ejection fraction 31%). A 27-year-old woman with subacute biventricular heart failure refractory to medication required orthotopic cardiac transplantation before the diagnosis was established (LV ejection fraction 25%). Genetic studies showed that these two patients with cardiomyopathy from unrelated families were heterozygous for the HFE 845G-->A (C282Y) mutation and wild-type at the H63D locus: complete sequencing of the intron-exon boundaries and entire coding sequence of the HFE gene failed to identify additional lesions. Two siblings in a pedigree without cardiomyopathy were wild-type at the HFE C282Y locus; although the brother harboured a single copy of the 187C-->G (H63D) allele, segregation analysis showed that in neither sibling was the iron-storage disease linked to MHC Class I markers on chromosome 6p. Juvenile haemochromatosis is thus a genetically heterogenous disorder distinct from the common adult variant.  (+info)

Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution. (5/3854)

Monoclonal antibodies (MoAb) labeled with 90Y are being used for radioimmunotherapy. Because 90Y is a beta emitter, quantitative information from imaging is suboptimal. With the concept of a "matched pair" of isotopes, 111In is used as a surrogate markerfor90Y. We evaluated the differences in biodistribution between 111In- and 90Y-labeled murine antiTac MoAb directed against the IL-2Ralpha receptor. METHODS: The antiTac was conjugated to the 2-(4-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid (1B4M-DTPA, also known as MX-DTPA). Nine patients with adult T-cell leukemia were treated. Patients received approximately 185 MBq (5 mCi) 111In-labeled antiTac for imaging and 185-555 MBq (5-15 mCi) 90Y-labeled antiTac for therapy. The immunoreactivity of 111In-labeled antiTac was 90%+/-6%, whereas for 90Y-labeled antiTac, it was 74%+/-12%. RESULTS: The differences in blood and plasma kinetics of the two isotopes were small. The area undemeath the blood radioactivity curve was 1.91 percentage+/-0.58 percentage injected dose (%ID) x h/mL for 111In and 1.86%+/-0.64 %ID x h/mL for 90Y. Urinary excretion of 90Y was significantly greater than that of 111In in the first 24 h (P = 0.001), but later, the excretion of 111In was significantly greater (P = 0.001 to P = 0.04). Core biopsies of bone marrow showed a mean of 0.0029+/-0.0012 %ID/g for 111In, whereas the 90Y concentration was 0.0049+/-0.0021 %ID/g. Analyses of activity bound to circulating cells showed concentrations of 500-30,000 molecules of antiTac per cell. When cell-bound activity was corrected for immunoreactive fraction, the ratio of 111In to 90Y in circulating cells was 1.11+/-0.17. Three biopsies of tumor-involved skin showed ratios of 111In to 90Y of 0.7, 0.9 and 1.1. CONCLUSION: This study shows that differences typically ranging from 10% to 15% exist in the biodistribution between 111In- and 90Y-labeled antiTac. Thus, it appears that 111In can be used as a surrogate marker for 90Y when labeling antiTac with the 1 B4M chelate, although underestimates of the bone marrow radiation dose should be anticipated.  (+info)

Augmentation is a potentiation of the exocytotic process. (6/3854)

Short-term synaptic enhancement is caused by an increase in the probability with which synaptic terminals release transmitter in response to presynaptic action potentials. Since exocytosed vesicles are drawn from a readily releasable pool of packaged transmitter, enhancement must result either from an increase in the size of the pool or an elevation in the fraction of releasable vesicles that undergoes exocytosis with each action potential. We show here that at least one major component of enhancement, augmentation, is not caused by an increase in the size of the readily releasable pool but is instead associated with an increase in the efficiency with which action potentials induce the exocytosis of readily releasable vesicles.  (+info)

Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections. (7/3854)

Marrow cells from mice lacking high-affinity receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF; betac-/- mice) were shown to bind and internalize much less GM-CSF than cells from normal (betac+/+) mice. betac-/- mice were used to determine the effect of negligible receptor-mediated clearance on detectible GM-CSF responses to the intravenous injection of endotoxin or the intraperitoneal injection of casein plus microorganisms. Unlike the minor serum GM-CSF responses to endotoxin seen in betac+/+ mice, serum GM-CSF levels rose 30-fold to 9 ng/mL in betac-/- mice even though loss of GM-CSF in the urine was greater than in betac+/+ mice. Organs from betac-/- and betac+/+ mice had a similar capacity to produce GM-CSF in vitro, as did peritoneal cells from both types of mice when challenged in vitro by casein. However, when casein was injected intraperitoneally, betac-/- mice developed higher and more sustained levels of GM-CSF than did betac+/+ mice. The data indicated that receptor-dependent removal of GM-CSF masks the magnitude of GM-CSF responses to endotoxin and local infections. Because of this phenomenon, serum GM-CSF concentrations can be a misleading index of the occurrence or nonoccurrence of GM-CSF responses to infections.  (+info)

Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation. (8/3854)

Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca2+]i). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca2+]i elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca2+]i with relatively high magnitude, which mimics the [Ca2+]i rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca2+]i reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information.  (+info)

... s are a class of ion-exchange resins. They are almost always used to bind cations, and utilize chelating agents ... The variation in chelating resins arises from the nature of the chelating agents pendant from the polymer backbone. Dowex ... Chelating resins operate similarly to ordinary ion-exchange resins. Most chelating resins are polymers (copolymers to be ... ISSN 1097-4628.. (CS1 errors: missing periodical, Analytical chemistry, Polymers, Resins, Chelating agents). ...
Equilibrium chemistry, Chelating agents). ... The chelating properties of aminopolycarboxylates can be ...
Homogeneous catalysis, Chelating agents, Diphosphines). ...
Chelating agents, Diphosphines, Phosphorus heterocycles). ...
... chelating agent EDTMP: Ethylenediaminetetra(methylenephosphonic acid), chelating agent TDTMP: Tetramethylenediaminetetra( ... methylenephosphonic acid), chelating agent HDTMP: Hexamethylenediaminetetra(methylenephosphonic acid), chelating agent DTPMP: ... Phosphonates are effective chelating agents. That is, they bind tightly to di- and trivalent metal ions, which is useful in ... In detergents they are used as a combination of chelating agent, scale inhibitor, and bleach stabilizer. Phosphonates are also ...
The chelating agent may be administered intravenously, intramuscularly, or orally, depending on the agent and the type of ... Other chelating agents have been discovered. They all function by making several chemical bonds with metal ions, thus rendering ... Other chelating agents, such as 2,3-dimercaptopropanesulfonic acid (DMPS) and alpha lipoic acid (ALA), are used in conventional ... Research in the former Soviet Union led to the introduction of DMPS, another dithiol, as a mercury-chelating agent. The Soviets ...
Lions, F. (1961). "The design of multidentate chelating agents". Record of Chemical Progress. 22: 69-78. ISSN 0034-1584. PMID ...
In tissue culture EDTA is used as a chelating agent that binds to calcium and prevents joining of cadherins between cells, ... Candidate chelating agents include nitrilotriacetic acid (NTA), iminodisuccinic acid (IDS), polyaspartic acid, S,S- ... "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... chelating agent. Many of the resulting coordination compounds adopt octahedral geometry. Although of little consequence for its ...
It is used as a source of the chelating agent EDTA4-. A 1% aqueous solution has a pH of approximately 11.3. When dissolved in ... It is sometimes used as a chelating agent. The assignee on 5% of patents at the USPTO containing the substance is the firm ... "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... Zaitoun, Mohammed A.; Lin, C. T. (1997). "Chelating Behavior between Metal Ions and EDTA in Sol−Gel Matrix". The Journal of ...
Most MMP inhibitors are chelating agents. The inhibitor binds to the zinc at the active center of the enzyme, thereby blocking ... One is a chelating moiety that interacts with the zinc ion and the other is a hydrophobic extension from the catalytic site ... In vitro, EDTA, 1,10-phenanthroline and other chelating compounds lower the concentration of metal to the point where the metal ... It is an antitumor and antiangiogenic agent with oral bioavailability. Inhibition of TACE and MMP-1 are linked to the ...
Hart, J. Roger (2005). "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial ... It serves as a buffering agent, maintaining pH and preventing sample damage during electrophoresis. Glycine is also used to ... as an agent in metal complexing and finishing. Glycine is not widely used in foods for its nutritional value, except in ...
These ligands are called chelants, chelators, chelating agents, or sequestering agents. They are usually organic compounds, but ... Chelating agents convert these metal ions into a chemically and biochemically inert form that can be excreted. Chelation using ... Such chelating agents include the porphyrin rings in hemoglobin and chlorophyll. Many microbial species produce water-soluble ... EDTA is the typical chelating agent that keeps these metal ions in a soluble form. Dechelation (or de-chelation) is a reverse ...
There is insufficient evidence that iron chelating agents such as deferoxamine and deferiprone improve outcomes of those with ... Cochrane Infectious Diseases Group) (2003-04-22). "Iron chelating agents for treating malaria". The Cochrane Database of ... The co-infection was found to reduce the virulence of the Plasmodium parasite, the causative agent of malaria. This reduction ... There is insufficient data on whether osmotic agents such as mannitol or urea are effective in treating cerebral malaria. ...
A chelating agent is a molecule with at least two negatively charged groups that allow it to form complexes with metal ions ... Chelating agents can have adverse effects; for example, chelation therapy can lower the body's levels of necessary nutrients ... Chelating agents taken orally can increase the body's absorption of lead through the intestine. Chelation challenge, also known ... The chelating agents used for treatment of lead poisoning are edetate disodium calcium (CaNa2EDTA), dimercaprol (BAL), which ...
... chelating agent 2,3-dimercapto-1-propanesulfonic acid. This method however has been proven[citation needed] to provide ... the human metabolism of chelating agents; and biochemical genetics in particular gene transfer in mammalian cells. Aposhian has ...
Chelating agents, Chelating agents used as drugs, Carboxylic acids, Peptides, All stub articles, Pharmacology stubs). ... Pendetide (GYK-DTPA) is a chelating agent. It consists of pentetic acid (DTPA) linked to the tripeptide glycine (G) - L- ...
"Enzymes and chelating agent in cotton pretreatment". Journal of Biotechnology. 89 (2-3): 271-279. doi:10.1016/S0168-1656(01) ...
A most prominent derivative of ethylenediamine is the chelating agent EDTA, which is derived from ethylenediamine via a ... Hydroxyethylethylenediamine is another commercially significant chelating agent. Numerous bio-active compounds and drugs ... Chelating agents, Fuel antioxidants, Corrosion inhibitors, Commodity chemicals, Ethyleneamines, Foul-smelling chemicals, ... The derivative N,N-ethylenebis(stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline ...
Henriksen G, Hoff P, Larsen RH (May 2002). "Evaluation of potential chelating agents for radium". Applied Radiation and ...
CS1 errors: periodical ignored, Biomolecules, Chelating agents, Porphyrins). ...
The effect of chelating agents on soil sodicity. Soil and Sediment Contamination 16: 301-312. Farooq Ahmad. "Karnal / Kallar ... In viticulture, adding naturally occurring chelating agents such as tartaric acid to irrigation water has been suggested, to ...
CS1 errors: periodical ignored, Chelating agents, Tetrapyrroles, Macrocycles). ... Additionally, corroles and their metal complexes have been demonstrated to be useful as imaging agents in tumor detection, ... oxygen sensing, for prevention of heart disease, in synthetic chemistry as oxo, imido, and nitrido transfer agents, and as ...
Sodium Thiosulfate (STS) is a calcium-chelating agent. It is typically used by patients who have excess calcium in their ...
These multidentate Lewis bases are called chelating agents. Lewis acids and bases are commonly classified according to their ...
... mor humus is produced which provides a greater amount of chelating agents. In podsolisation, chelating agents break down clay ... These organic acids are known as chelating agents. Many podsol soils form underneath coniferous forests, the fact that pine ...
One representative chelating agent is H5DTPA, diethylenetriaminepentaacetic acid. Chelation to the conjugate base of this ... "Free" gadolinium(III), e.g. [GdCl2(H2O)6]+, is toxic, so chelating agents are essential for biomedical applications. Simple ... GdCl3∙6H2O can not be used as an MRI contrasting agent due to its low solubility in water at the body's near neutral pH. " ... To generate the relaxation agents, Gd3+ sources such as GdCl3∙6H2O are converted to coordination complexes. ...
... is a heterocyclic organic compound and chelating agent. Phenanthroline ligands were first published in the late ...
Iron ionophores and chelating agents are collectively called siderophores. Many synthetic ionophores are based on crown ethers ... It also serves as an anti-fouling agent in paints to cover and protect surfaces against mildew and algae. Clioquinol and PBT2 ... It is also used as a food additive, shelf-life extending agent in food packaging, and wood preservative in timber treatment. ... Some synthetic agents are not macrocyclic, e.g. carbonyl cyanide-p-trifluoromethoxyphenylhydrazone. Even simple organic ...
It has been widely investigated as a chelating agent. Many derivatives are known. Bispidine has a bicyclic scaffold consisting ...
Butadiene, cyclooctadiene, and norbornadiene are well-studied chelating agents. Trienes and even some tetraenes can bind to ...
The principal function of this chelating agent is to chemically bind and render inactive those trace metals having an adverse ... The principal function of this chelating agent is to chemically bind and render inactive those trace metals having an adverse ...
Pharmacological Actions : Antioxidant, Iron Chelating Agents, Neuroprotective Agents, Regenerative. Additional Keywords : Nerve ... Pharmacological Actions : Iron Chelating Agents, Neuroprotective Agents, Regenerative. Additional Keywords : Nerve Regeneration ... Pharmacological Actions : Anti-Apoptotic, Iron Chelating Agents, Neuroprotective Agents, Superoxide Dismutase Up-regulation ... 19 Abstracts with Iron Chelating Agents Research. Filter by Study Type. Animal Study. ...
The global chelating agents market size was $4,757.1 Mn in 2019 & projected to reach $6,396.9 Mn by 2027 at a CAGR of 4.4% ... Chelating Agents Market Size, Share & COVID-19 Impact Analysis, By Product Type (Sodium Gluconate, Organophosphonates, EDTA & ...
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On the Role of Iron and one of its Chelating Agents in the Production of Protoporphyrin IX Generated by 5-Aminolevulinic Acid ... specific chelating agent deferoxamine (DFO). PPIX fluorescence from the Epidex™ layers was measured up to 150 h after the ... "On the Role of Iron and one of its Chelating Agents in the Production of Protoporphyrin IX Generated by 5-Aminolevulinic Acid ... "On the Role of Iron and one of its Chelating Agents in the Production of Protoporphyrin IX Generated by 5-Aminolevulinic Acid ...
Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram. Shine-Gwo Shian, Yu-Rung Kao, Felicia Ying-Hsiueh ... Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram. Shine-Gwo Shian, Yu-Rung Kao, Felicia Ying-Hsiueh ... Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram. Shine-Gwo Shian, Yu-Rung Kao, Felicia Ying-Hsiueh ... Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram Message Subject (Your Name) has forwarded a page to ...
This includes surfactant, cheating agent, solvent, and others. According to the report, chelating agent held the majority of ... Chelating Agent, Solvent, and Others), End use (Manufacturing, Automotive, Aerospace, and Others), and Region 2024-2032 ... Some of the metal cleaning chemicals available in the market are alkaline cleaning agents that are used to remove mineral ...
... to mixtures of chelating agents and methods using such chelating agents. ... The present invention relates to a process for in situ the preparation of mixtures of chelating agents by catalyzed reactions ... a chelating agent effectively chelating calcium would be consumed by calcium ions. Therefore, chelating agents to selectively ... Process for the preparation of a mixture of chelating agents, mixture of chelating agents and methods of using them ...
Category: Chelating agent What is Sodium Gluconate (E576) in food and other uses?. Chelating agent 1 Comment ...
Chelating Shampoo Recently there has been an increase of chelating shamp ... Chelating agents are a category of ingredients responsible for preventing, and in some cases removing, build up in your hair by ... What is a Chelating Agent?. Chelating agents are a category of ingredients responsible for preventing, and in some cases ... Chelating Agents in Waterless Formulas. Chelating agents are especially significant in waterless formulations as they are ...
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3,4,3-LI(1,2-HOPO) gadolinium chelator cas 110874-36- ...
Chelating Agents / pharmacology* * Computer Simulation * Drug Evaluation, Preclinical* * Enzyme Inhibitors / analysis* * Enzyme ... The newly identified inhibitors are structurally diverse and have various chelating groups for the active-site ferrous ion ... identification of new chelating groups for the active-site ferrous ion Bioorg Med Chem. 2009 Nov 15;17(22):7769-74. doi: ...
Chelating Agents. Class Summary. Chelating agents help reduce iron levels in the body by promoting the excretion of chelated ... Pharmacogenetic study of deferasirox, an iron chelating agent. PLoS One. 2013. 8(5):e64114. [QxMD MEDLINE Link]. [Full Text]. ... Iron-chelating therapy for transfusional iron overload. N Engl J Med. 2011 Jan 13. 364(2):146-56. [QxMD MEDLINE Link]. [Full ... Oral iron chelation agent that is demonstrated to reduce the liver iron concentration in adults and children who receive ...
Producing high quality Polyhydroxycarboxylic Acid Sodium Gluconate Powder Food Grade Chelating Agent products. ... High quality Polyhydroxycarboxylic Acid Sodium Gluconate Powder Food Grade Chelating Agent from China, Chinas leading Sodium ... Chelating Agent Sodium Gluconate, Concrete Sodium Gluconate Retarder, Sodium Gluconate In Concrete ... Polyhydroxycarboxylic Acid Sodium Gluconate Powder Food Grade Chelating Agent. Description. Name:. Sodium Gluconate Sodium ...
Global Green Chelating Agent Market 2017-2024. March 18, 2021. Fred BergBlog ... Green Chelating Agents Market size will witness substantial growth due to their high use in the residential and cleaning ... Its wide use in the manufacturing industry is expected to boost the size of the green chelating agent market. It is used to ... The growth of the pulp and paper production industry will positively affect the market share of green chelating agents. It is ...
Natural Chelating Agents Industry by Product, Application and Region. ... Natural Chelating Agents Market valued USD 6.8 Billion by 2030 from USD 4.5 Billion in 2021 at a CAGR of 4.5%. ... Natural Chelating Agents Market Dynamics: The chelating agent is known as a chemical compound that reacts with the metal ions ... Natural Chelating Agents Market Insights:. Natural Chelating Agents Market was valued at USD 4.5 Billion in 2021, registering a ...
When Detox is Dangerous - Part 3 of 3) The "How To" of True ...
PHARMACOLOGY OF CHELATING AGENTS. BAL. CaNa2EDTA. D-PENICILLAMINE. SUCCIMER. TREATMENT GUIDELINES FOR CHILDREN WITH BLOOD LEAD ... EFFICACY OF CHELATING AGENTS. SUCCIMER. TOXICITY OF CaNa2EDTA. REFERENCES. CHAPTER 8. MANAGEMENT OF LEAD HAZARDS IN THE ... PHARMACOLOGY OF CHELATING AGENTS. Table 7 1 Several drugs are used in the treatment of lead poisoning. These drugs, capable of ... PHARMACOLOGY OF CHELATING AGENTS. TREATMENT GUIDELINES FOR CHILDREN WITH BLOOD LEAD LEVELS , OR = 20 UG/DL.. POST-CHELATION ...
Chelating agents. Families[edit]. Inhibitor I4[edit]. This is a family of protease suicide inhibitors called the serpins. It ...
... crystalline chelating agent, useful in formulating dry products or where the total water content of a product must be kept to a ... A dry, crystalline chelating agent, useful in formulating dry products or where the total water content of a product must be ... Chelating Agent. Conditioners. Cosmetics. Deodorants. Detergents. Electroplating. Eye Drops. Eye Liner. Facial Cleaner. ... VERSENE™ NA2 Crystals Chelating Agent - Technical Grade - 25 kg Bag IN YOUR CART ...
Chelating resins are a class of ion-exchange resins. They are almost always used to bind cations, and utilize chelating agents ... The variation in chelating resins arises from the nature of the chelating agents pendant from the polymer backbone. Dowex ... Chelating resins operate similarly to ordinary ion-exchange resins. Most chelating resins are polymers (copolymers to be ... ISSN 1097-4628.. (CS1 errors: missing periodical, Analytical chemistry, Polymers, Resins, Chelating agents). ...
chelating agent/antioxidant synergists. 2.3.1. -food acidulant have ability to form ring structure with metal ion - process ... 2.3.2. citric acid- strongest chelating agent. 2.4. flavour adjuncts. 2.4.1. -acidulant add tartness required to balance ... pH control agents. 2.2.1. f(x) -obtain certain pH range -maintain acidic pH and tartness of carbonated beverages ... 2.1.2. serves as anti browning agent -maintain normal flavor,colour and texture ...
Anti-rust agents contain different poisonous substances, including: *Chelating agents. *Hydrocarbons. *Hydrochloric acid ...
chelating agent, fragrance ingredient, ph adjuster, buffering, chelating, masking. CONCERNS. • Use restrictions (moderate). ... skin-conditioning agent - emollient, surfactant - emulsifying agent, emollient, emulsifying. CONCERNS. • Enhanced skin ... antiacne agent, antidandruff agent, corn/callus/wart remover, denaturant, exfoliant;fragrance ingredient, hair conditioning ... surfactant - cleansing agent, cleansing, surfactant. CONCERNS. • Use restrictions (low). • Irritation (skin, eyes, or lungs) ( ...
Different chelating molecules can be used to guide Tc-99m through various physiological pathways in the body to gain ... Chelating Agents / chemistry * Heterocyclic Compounds, 1-Ring / chemistry * Humans * Metals, Rare Earth / therapeutic use* ... Different chelating molecules can be used to guide Tc-99m through various physiological pathways in the body to gain ... therapeutic radiopharmaceutical agents, the individual members of which can be tailored to treat specific types of cancers. ...
Dimercaptosuccinic acid is a chelating agent; romiplostim is a bone marrow stimulant. ...
  • The most common chelating agents found in cosmetic formulations are tetrasodium EDTA and tetrahydroxypropyl ethylenediamine. (susteau.com)
  • Additionally, the harmful impacts of toxic synthetic chelating agents such as nitrilotriacetic acid and ethylenediaminetetraacetic acid (EDTA) owing to the non-biodegradability and high water insolubility also restrict the growth of natural chelating agents market during the forecast period. (marketresearchcommunity.com)
  • Until now, chelating agents such as ethylenediaminetetraacetic acid (EDTA) was the only option to address the presence of Mg2+ in samples. (ewha.ac.kr)
  • Use a chelating agent like EDTA. (dsm.com)
  • PPIX production was modulated with (L ) ascorbic acid iron (II) salt (LAI) or the iron (II)-specific chelating agent deferoxamine (DFO). (bioone.org)
  • At Susteau, we use sodium phytate as our chelating agent. (susteau.com)
  • If the steel surface needs to be coated, chrome plated, tin pl ated, nickel plating to adapt to special uses, cleaning agent adding sodium gluconate will achieve very ideal effect. (fuyangsweetener.com)
  • For instance, natural chelating agents received acceptance from regulatory authorities like the National Institute of Health and Food and Drugs Administration in terms of safe for use on the skin and eyes, which resulted in the large usage of natural chelating agents such as sodium gluconate and glutamic acid diacetate (GLDA) in cosmetic products. (marketresearchcommunity.com)
  • The factors such as rising inclination towards natural substitutes like sodium gluconate to conventional sequesters especially in cosmetic, detergent, and cleaning products, rising cleaning applications due to increased hygiene awareness among the population, and growing expenditure from major industry players for facilitation of innovative, clean products are projected to accelerate the natural chelating agents market in the Asia Pacific region. (marketresearchcommunity.com)
  • Shandong Taihe Technologies Co., Ltd. has developed several eco-friendly products?that?has?reached?thousand?metric?ton?production?capacity,?including?Sodium of Polyepoxysuccinic acid (PESA), Polyaspartic Acid (PASP), Glutamic Acid N N-diacetic Acid Tetra Sodium Salt (TH-GC Green Chelating Agent) etc. (mdjeootv.com)
  • Natural Chelating Agents Market was valued at USD 4.5 Billion in 2021, registering a CAGR of 4.5% during the forecast period (2022-2030), and the market is projected to be worth USD 6.8 Billion by 2030. (marketresearchcommunity.com)
  • Chelating polymers (ion-exchange resins) were proposed for maintenance therapy of pathologies accompanied by iron accumulation, such as hereditary hemochromatosis (iron overload) or Wilson's disease (copper overload), by chelating the metal ions in GIT and thus limiting its biological availability. (wikipedia.org)
  • The small amount of a chelating ingredient in an everyday shampoo is designed to prevent this build up as opposed to removing it. (susteau.com)
  • For example, hard water can decrease the amount of lather in a shampoo and a chelating ingredient can prevent that. (susteau.com)
  • In pulp bleaching liquors, iron and manganese ions are desired to be trapped by a chelating agent, thereby inhibiting these metal ions from catalyzing the decomposition of the bleaching agents, hydrogen peroxide or peroxy acids. (justia.com)
  • Because there is naturally a high concentration of calcium ions in the bleaching liquors, a chelating agent effectively chelating calcium would be consumed by calcium ions. (justia.com)
  • Therefore, chelating agents to selectively complex iron and manganese ions are desired. (justia.com)
  • In order to simultaneously complex different metal ions in aqueous solutions, it is essential in many applications to have a mixture of chelating agents having different ligand structure. (justia.com)
  • Natural chelating agents are biodegradable chemical compositions that bind with the metal ions and play a vital role in the efficacy and stability of multiple products such as agrichemicals, cosmetics, and food & beverage. (marketresearchcommunity.com)
  • The chelating agent is known as a chemical compound that reacts with the metal ions for the formation of water-soluble and stable metal complexes. (marketresearchcommunity.com)
  • Most chelating resins are polymers (copolymers to be precise) with reactive functional groups that chelate to metal ions. (wikipedia.org)
  • Mittal, S., "Chelating Resins and Their Applications in the Analysis of Trace Metal Ions", Microchem. (wikipedia.org)
  • Koel, M., "Analysis of trace amounts of metal ions using silica-based chelating resins: A green analytical method", Crit. (wikipedia.org)
  • Used in LGE assessment, gadolinium is an extracellular chelating agent that permeates the interstitial space of both normal and abnormal myocardium . (medscape.com)
  • Alpha-lipoic acid possesses excellent iron chelating properties. (greenmedinfo.com)
  • Pascal Uehlinger , Jean-Pierre Ballini , Hubert van den Bergh , and Georges Wagnières "On the Role of Iron and one of its Chelating Agents in the Production of Protoporphyrin IX Generated by 5-Aminolevulinic Acid and its Hexyl Ester Derivative Tested on an Epidermal Equivalent of Human Skin," Photochemistry and Photobiology 82(4), 1069-1076, (1 July 2006). (bioone.org)
  • The present invention relates to a process for in situ the preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine derivatives with maleic acid and then with 2-halocarboxylic acid, to mixtures of chelating agents and methods using such chelating agents. (justia.com)
  • WO 97/45396 discloses N-bis- and N-tris-[(1,2-dicarboxy-ethoxy)-ethyl]-amine derivatives including N-bis-[(1,2-dicarboxy-ethoxy)-ethyl]-aspartic acid (also called aspartic acid diethoxy succinate or AES), and the use of these derivatives as chelating agents of metals, especially in connection with pulp bleaching. (justia.com)
  • It has now been surprisingly found that mixtures of chelating agents having a diethanol amine backbone can be effectively prepared by lanthanoid-catalysed reaction of bis-(2-hydroxyethyl)glycine or bis-(2-hydroxyethyl)methyl glycine, or salts thereof with a maleate followed by a subsequent lanthanide-catalyzed reaction with a 2-halocarboxylic acid. (justia.com)
  • The increased rising demand from the cosmetic industry for reduced risks of oxidation and rancidity and increased awareness of biodegradable sequestering agents such as ethylene diamine disuccinate (EDDS) and glutamic acid diacetate (GLDA) are the major factors that boost the growth of natural chelating agents market. (marketresearchcommunity.com)
  • Dowex chelating resin A-1, also known as Chelex 100, is based on iminodiacetic acid in a styrene-divinylbenzene matrix. (wikipedia.org)
  • They are composed of a weak base and acid in water, and according to the needs, other elements such as solvents, chelating agents and surfactants can be added before the mixture is gelled. (openedition.org)
  • They are almost always used to bind cations, and utilize chelating agents covalently attached to a polymer matrix. (wikipedia.org)
  • Therapeutic potential of silymarin as a natural iron-chelating agent in β-thalassemia intermedia. (greenmedinfo.com)
  • Thus, the radiolanthanide-DOTA bioconjugate model provides a set of physically diverse, but chemically very similar, therapeutic radiopharmaceutical agents, the individual members of which can be tailored to treat specific types of cancers. (nih.gov)
  • Chelating resins are a class of ion-exchange resins. (wikipedia.org)
  • Chelating resins have the same bead form and polymer matrix as usual ion exchangers. (wikipedia.org)
  • Chelating ion-exchange resins are used for brine decalcification in the chlor-alkali industry, the removal of boron from potable water, and the recovery of precious metals in solutions. (wikipedia.org)
  • Chelating resins operate similarly to ordinary ion-exchange resins. (wikipedia.org)
  • The variation in chelating resins arises from the nature of the chelating agents pendant from the polymer backbone. (wikipedia.org)
  • Dowex A-1 is available commercially and is widely used to determine general properties of chelating resins such as rate determining step and pH dependence, etc. (wikipedia.org)
  • Other functional groups bound to chelating resins are aminophosphonic acids, thiourea, and 2-picolylamine. (wikipedia.org)
  • Soil contaminated with heavy metals including radionuclides is mitigated primarily using chelating resins. (wikipedia.org)
  • The scope of clean alternatives in multiple industries such as the oil processing market, detergents, and garment market combined with the augmented expansion of eCommerce sectors in developing countries like India, Brazil, and Mexico owing to the large scale supply of the products is expected to create lucrative opportunities for the natural chelating agents market. (marketresearchcommunity.com)
  • When treatment combining transfusion and iron-chelating agent is started early and maintained, the patient's quality of life can be very good and the prognosis is optimistic. (who.int)
  • Additionally, increased demand for vegan cosmetics is also expected to support the growth of natural chelating agents owing to the growing use of natural chelating agents in cosmetic production. (marketresearchcommunity.com)
  • Its wide use in the manufacturing industry is expected to boost the size of the green chelating agent market. (basementgeographer.com)
  • Thus, favorable regulations for increased demand for vegan cosmetic products are expected to boost the natural chelating agents market during the forecast period due to the large usage of natural chelating agents. (marketresearchcommunity.com)
  • As a result of multiple transfusions over the years, various organs become severely overloaded with iron, and, in order to avoid death in adolescence, regular subcutaneous infusion of an iron-chelating agent is essential. (who.int)
  • Furthermore, the rising demand for natural chelating products due to low nitrogen toxicity and biodegradability are the major factors that fuel the growth of the natural chelating agents market. (marketresearchcommunity.com)
  • Chelating agents are a category of ingredients responsible for preventing, and in some cases removing, build up in your hair by forming multiple bonds to a metal ion or metallic compound. (susteau.com)
  • Chelating treatments should no be used as frequently as a chelating shampoo as they have a higher amount of chelating ingredients and a noticeable difference can be seen after a single use. (susteau.com)
  • The surging use of natural chelating agents especially in the manufacturing of cosmetic products is expected to contribute to the growth of the natural chelating agents market due to non-toxic and environment-friendly applications. (marketresearchcommunity.com)
  • Chelating agents help reduce iron levels in the body by promoting the excretion of chelated iron. (medscape.com)
  • Oral iron chelation agent that is demonstrated to reduce the liver iron concentration in adults and children who receive repeated RBC transfusions. (medscape.com)
  • Haemosiderosis, which plays a considerable function in thalassaemia patients before and role in early mortality, can be prevented or after treatment with high-dose deferoxam- postponed by iron-chelating agents which ine. (who.int)
  • 1200 used iron-chelating agent. (who.int)
  • Successful development of a more widely accessible and acceptable, oral iron-chelating agent could solve the problem of compliance in countries with limited resources, where morbidity and mortality are mainly caused by limited access to appropriate medical care. (who.int)
  • Therefore, there is a need to develop a method for the preparation of mixtures of chelating agents in situ in the same reaction mixture. (justia.com)
  • Naturally occurring chelating agents are more favorable for the removal of toxins from soluble concentrations due to their biodegradable and nontoxic properties. (marketresearchcommunity.com)
  • Some of the metal cleaning chemicals available in the market are alkaline cleaning agents that are used to remove mineral deposits and rust. (imarcgroup.com)
  • The agent rearranges the chemical composition of metal to improve the general bonding likelihood and stability. (marketresearchcommunity.com)
  • Chelating agents are especially significant in waterless formulations as they are responsible for making sure the products give the same performance no matter what the chemistry of the water being used is. (susteau.com)
  • The increasing need for water treatment due to increasing water pollution has driven the demand for the green chelating agent market. (basementgeographer.com)
  • Electrical discharge treatment was shown to be a viable substitution for chelating agent in genomic assays. (ewha.ac.kr)
  • Thus, rising demand for clean, animal cruelty products among the population is estimated to contribute to the growth of the natural chelating agents market. (marketresearchcommunity.com)
  • A dry, crystalline chelating agent, useful in formulating dry products or where the total water content of a product must be kept to a minimum. (chemcentral.com)
  • Green Chelating Agents Market size will witness substantial growth due to their high use in the residential and cleaning industry. (basementgeographer.com)
  • In the context of the region, Asia Pacific is anticipated to contribute to the growth of the natural chelating agents market. (marketresearchcommunity.com)
  • The lack of awareness of natural chelating agents hampers the growth of the natural chelating agents market due to reduced industry penetration. (marketresearchcommunity.com)
  • Chelating agents attach to compounds in hard water ensuring that the performance of the just-add-water formula is not compromised. (susteau.com)
  • The growth of the pulp and paper production industry will positively affect the market share of green chelating agents. (basementgeographer.com)
  • Chelating shampoos are simply shampoos with an increased level of chelating agents, designed to remove build-up in the hair. (susteau.com)