Calcium Signaling: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Calcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Medicare Assignment: Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Economic Competition: The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Health Care Sector: Economic sector concerned with the provision, distribution, and consumption of health care services and related products.Marketing of Health Services: Application of marketing principles and techniques to maximize the use of health care resources.Alginates: Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.Hexuronic Acids: Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Flocculation: The aggregation of suspended solids into larger clumps.Corrosion: The gradual destruction of a metal or alloy due to oxidation or action of a chemical agent. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Steel: A tough, malleable, iron-based alloy containing up to, but no more than, two percent carbon and often other metals. It is used in medicine and dentistry in implants and instrumentation.Disinfectants: Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)Allium: A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.Onions: Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.Meristem: A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.Chelation Therapy: Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.Iron Chelating Agents: Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.Zeolites: Zeolites. A group of crystalline, hydrated alkali-aluminum silicates. They occur naturally in sedimentary and volcanic rocks, altered basalts, ores, and clay deposits. Some 40 known zeolite minerals and a great number of synthetic zeolites are available commercially. (From Merck Index, 11th ed)Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)Hydroxides: Inorganic compounds that contain the OH- group.Potassium Compounds: Inorganic compounds that contain potassium as an integral part of the molecule.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Antibodies, Archaeal: Immunoglobulins produced in a response to ARCHAEAL ANTIGENS.Fuel Oils: Complex petroleum hydrocarbons consisting mainly of residues from crude oil distillation. These liquid products include heating oils, stove oils, and furnace oils and are burned to generate energy.Fossil Fuels: Any combustible hydrocarbon deposit formed from the remains of prehistoric organisms. Examples are petroleum, coal, and natural gas.Extraction and Processing Industry: The industry concerned with the removal of raw materials from the Earth's crust and with their conversion into refined products.Geology: The science of the earth and other celestial bodies and their history as recorded in the rocks. It includes the study of geologic processes of an area such as rock formations, weathering and erosion, and sedimentation. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Industrial Microbiology: The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.Macrocyclic Compounds: Cyclic compounds with a ring size of approximately 1-4 dozen atoms.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Chelating Agents: Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Unithiol: A chelating agent used as an antidote to heavy metal poisoning.Benzoates: Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.TriazolesIron Overload: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)Molecular Weight: The sum of the weight of all the atoms in a molecule.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Weight Loss: Decrease in existing BODY WEIGHT.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Soil: The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.China: A country spanning from central Asia to the Pacific Ocean.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Nitric Acid: Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed)Shikimic Acid: A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it.Sorbic Acid: Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.Spectrophotometry, Atomic: Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.Eye Diseases: Diseases affecting the eye.BooksBacteriology: The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.Nobel PrizePatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Heterocyclic Compounds, 1-Ring: A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Silicones: A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)Cosmetic Techniques: Procedures for the improvement or enhancement of the appearance of the visible parts of the body.Silicone Oils: Organic siloxanes which are polymerized to the oily stage. The oils have low surface tension and density less than 1. They are used in industrial applications and in the treatment of retinal detachment, complicated by proliferative vitreoretinopathy.Callosities: Localized hyperplasia of the horny layer of the epidermis due to pressure or friction. (Dorland, 27th ed)Silicone Elastomers: Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.Acrylonitrile: A highly poisonous compound used widely in the manufacture of plastics, adhesives and synthetic rubber.Acetic Anhydrides: Compounds used extensively as acetylation, oxidation and dehydrating agents and in the modification of proteins and enzymes.Ethanolamine: A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.AcrylatesEncyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Allied Health Occupations: Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.Library Collection Development: Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.Textbooks as Topic: Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.Body Fluids: Liquid components of living organisms.Chemistry, Bioinorganic: Field of chemistry pertaining to the study of inorganic compounds or ions and their interactions with biological ligands at the molecular level.Chemistry, Inorganic: A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).Porphyridium: A genus of RED ALGAE in the family Porphyridiaceae. A single stellate CHLOROPLAST is present in each cell which has no CELL WALL.GeorgiaItalyClomiphene: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.Ovulation Detection: Method to determine the occurrence of OVULATION by direct or indirect means. Indirect methods examine the effects of PROGESTERONE on cervical mucus (CERVIX MUCUS), or basal body temperature. Direct ovulation detection, generally used in fertility treatment, involves analyses of circulating hormones in blood and ULTRASONOGRAPHY.Fertile Period: The period in the MENSTRUAL CYCLE that is optimal for FERTILIZATION of the OVUM and yielding PREGNANCY. The duration of fertile period depends on the life span of male GAMETES within the female reproductive tract and the time of OVULATION. It usually begins a few days before ovulation and ends on the day of ovulation.Infertility, Female: Diminished or absent ability of a female to achieve conception.National Institute of Mental Health (U.S.): A component of the NATIONAL INSTITUTES OF HEALTH concerned with research, overall planning, promoting, and administering mental health programs and research. It was established in 1949.

The effect of chelating agents on iron mobilization in Chang cell cultures. (1/3854)

The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3-dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells. They are effective to an approximately equal degree. The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound. How far these phenomena relate to therapeutic potentially remains to be seen.  (+info)

Highly sensitive quantitation of methamphetamine by time-resolved fluoroimmunoassay using a new europium chelate as a label. (2/3854)

A simple and highly sensitive time-resolved fluoroimmunoassay of methamphetamine (MA) using a new fluorescent europium chelate (BHHCT-Eu3+) as a label is described. Two variations of competitive immunoassay were attempted. In the first (one-step) assay, microtiter plates coated with anti-MA were used, and the new label was bound to a conjugate of bovine serum albumin and N-(4-aminobutyl)-MA (MA-BSA). In the second (two-step) assay, instead of the labeled MA-BSA, biotinylated MA-BSA and BHHCT-Eu3+-labeled streptavidin-BSA were used. The lowest measurable concentrations of MA for the one-step and the two-step methods were 1 ng/mL (25 pg/assay) and 1 pg/mL (25 fg/assay), respectively. These were 10 to 1000 times superior to the detection limits of MA in any other immunoassay. Intra-assay coefficient of variation was approximately 2-8% at eight different concentrations (n = 4). Analysis of 34 urine samples with the new method and conventional gas chromatography showed a good correlation (r = 0.954). The high detectability of the present assay also enabled segmental hair analysis with a few centimeters of a hair.  (+info)

Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation. (3/3854)

Persistent potentiations of the chemical and electrotonic components of the eighth nerve (NVIII) EPSP recorded in vivo in the goldfish reticulospinal neuron, the Mauthner cell, can be evoked by afferent tetanization or local dendritic application of an endogenous transmitter, dopamine (3-hydroxytyramine). These modifications are attributable to the activation of distinct intracellular kinase cascades. Although dopamine-evoked potentiation (DEP) is mediated by the cAMP-dependent protein kinase (PKA), tetanization most likely activates a Ca2+-dependent protein kinase via an increased intracellular Ca2+ concentration. We present evidence that the eighth nerve tetanus that induces LTP does not act by triggering dopamine release, because it is evoked in the presence of a broad spectrum of dopamine antagonists. To test for interactions between these pathways, we applied the potentiating paradigms sequentially. When dopamine was applied first, tetanization produced additional potentiation of the mixed synaptic response, but when the sequence was reversed, DEP was occluded, indicating that the synapses potentiated by the two procedures belong to the same or overlapping populations. Experiments were conducted to determine interactions between the underlying regulatory mechanisms and the level of their convergence. Inhibiting PKA does not impede tetanus-induced LTP, and chelating postsynaptic Ca2+ with BAPTA does not block DEP, indicating that the initial steps of the induction processes are independent. Pharmacological and voltage-clamp analyses indicate that the two pathways converge on functional AMPA/kainate receptors for the chemically mediated EPSP and gap junctions for the electrotonic component or at intermediaries common to both pathways. A cellular model incorporating these interactions is proposed on the basis of differential modulation of synaptic responses via receptor-protein phosphorylation.  (+info)

Hereditary juvenile haemochromatosis: a genetically heterogeneous life-threatening iron-storage disease. (4/3854)

Juvenile haemochromatosis is a rare inborn error of iron metabolism with clinical manifestations before 30 years of age. Unlike adult haemochromatosis which principally affects men, juvenile haemochromatosis affects the sexes equally; it causes early endocrine failure, dilated cardiomyopathy and joint disease. We report four patients (two of each sex) from three pedigrees affected by juvenile haemochromatosis with a mean onset at 22 years (range 14-30). All had endocrine deficiency with postpubertal gonadal failure secondary to pituitary disease; two suffered near-fatal cardiomyopathy with heart failure. Mean time to diagnosis from the first clinical signs of disease was 9.8 years (range 0.5-20) but general health and parameters of iron storage responded favourably to iron-depletion therapy. A 24-year-old man listed for heart transplantation because of cardiomyopathy [left ventricular (LV) ejection fraction 16%] responded to intravenous iron chelation with desferrioxamine combined with phlebotomy (ejection fraction 31%). A 27-year-old woman with subacute biventricular heart failure refractory to medication required orthotopic cardiac transplantation before the diagnosis was established (LV ejection fraction 25%). Genetic studies showed that these two patients with cardiomyopathy from unrelated families were heterozygous for the HFE 845G-->A (C282Y) mutation and wild-type at the H63D locus: complete sequencing of the intron-exon boundaries and entire coding sequence of the HFE gene failed to identify additional lesions. Two siblings in a pedigree without cardiomyopathy were wild-type at the HFE C282Y locus; although the brother harboured a single copy of the 187C-->G (H63D) allele, segregation analysis showed that in neither sibling was the iron-storage disease linked to MHC Class I markers on chromosome 6p. Juvenile haemochromatosis is thus a genetically heterogenous disorder distinct from the common adult variant.  (+info)

Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution. (5/3854)

Monoclonal antibodies (MoAb) labeled with 90Y are being used for radioimmunotherapy. Because 90Y is a beta emitter, quantitative information from imaging is suboptimal. With the concept of a "matched pair" of isotopes, 111In is used as a surrogate markerfor90Y. We evaluated the differences in biodistribution between 111In- and 90Y-labeled murine antiTac MoAb directed against the IL-2Ralpha receptor. METHODS: The antiTac was conjugated to the 2-(4-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid (1B4M-DTPA, also known as MX-DTPA). Nine patients with adult T-cell leukemia were treated. Patients received approximately 185 MBq (5 mCi) 111In-labeled antiTac for imaging and 185-555 MBq (5-15 mCi) 90Y-labeled antiTac for therapy. The immunoreactivity of 111In-labeled antiTac was 90%+/-6%, whereas for 90Y-labeled antiTac, it was 74%+/-12%. RESULTS: The differences in blood and plasma kinetics of the two isotopes were small. The area undemeath the blood radioactivity curve was 1.91 percentage+/-0.58 percentage injected dose (%ID) x h/mL for 111In and 1.86%+/-0.64 %ID x h/mL for 90Y. Urinary excretion of 90Y was significantly greater than that of 111In in the first 24 h (P = 0.001), but later, the excretion of 111In was significantly greater (P = 0.001 to P = 0.04). Core biopsies of bone marrow showed a mean of 0.0029+/-0.0012 %ID/g for 111In, whereas the 90Y concentration was 0.0049+/-0.0021 %ID/g. Analyses of activity bound to circulating cells showed concentrations of 500-30,000 molecules of antiTac per cell. When cell-bound activity was corrected for immunoreactive fraction, the ratio of 111In to 90Y in circulating cells was 1.11+/-0.17. Three biopsies of tumor-involved skin showed ratios of 111In to 90Y of 0.7, 0.9 and 1.1. CONCLUSION: This study shows that differences typically ranging from 10% to 15% exist in the biodistribution between 111In- and 90Y-labeled antiTac. Thus, it appears that 111In can be used as a surrogate marker for 90Y when labeling antiTac with the 1 B4M chelate, although underestimates of the bone marrow radiation dose should be anticipated.  (+info)

Augmentation is a potentiation of the exocytotic process. (6/3854)

Short-term synaptic enhancement is caused by an increase in the probability with which synaptic terminals release transmitter in response to presynaptic action potentials. Since exocytosed vesicles are drawn from a readily releasable pool of packaged transmitter, enhancement must result either from an increase in the size of the pool or an elevation in the fraction of releasable vesicles that undergoes exocytosis with each action potential. We show here that at least one major component of enhancement, augmentation, is not caused by an increase in the size of the readily releasable pool but is instead associated with an increase in the efficiency with which action potentials induce the exocytosis of readily releasable vesicles.  (+info)

Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections. (7/3854)

Marrow cells from mice lacking high-affinity receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF; betac-/- mice) were shown to bind and internalize much less GM-CSF than cells from normal (betac+/+) mice. betac-/- mice were used to determine the effect of negligible receptor-mediated clearance on detectible GM-CSF responses to the intravenous injection of endotoxin or the intraperitoneal injection of casein plus microorganisms. Unlike the minor serum GM-CSF responses to endotoxin seen in betac+/+ mice, serum GM-CSF levels rose 30-fold to 9 ng/mL in betac-/- mice even though loss of GM-CSF in the urine was greater than in betac+/+ mice. Organs from betac-/- and betac+/+ mice had a similar capacity to produce GM-CSF in vitro, as did peritoneal cells from both types of mice when challenged in vitro by casein. However, when casein was injected intraperitoneally, betac-/- mice developed higher and more sustained levels of GM-CSF than did betac+/+ mice. The data indicated that receptor-dependent removal of GM-CSF masks the magnitude of GM-CSF responses to endotoxin and local infections. Because of this phenomenon, serum GM-CSF concentrations can be a misleading index of the occurrence or nonoccurrence of GM-CSF responses to infections.  (+info)

Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation. (8/3854)

Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca2+]i). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca2+]i elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca2+]i with relatively high magnitude, which mimics the [Ca2+]i rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca2+]i reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information.  (+info)

*Phosphonate

... chelating agent EDTMP: Ethylenediaminetetra(methylenephosphonic acid), chelating agent TDTMP: Tetramethylenediaminetetra( ... methylenephosphonic acid), chelating agent HDTMP: Hexamethylenediaminetetra(methylenephosphonic acid), chelating agent DTPMP: ... Phosphonates are effective chelating agents. That is, they bind tightly to di- and trivalent metal ions, which is useful in ... Since the work of Schwarzenbach in 1949, phosphonic acids are known as effective chelating agents. The introduction of an amine ...

*Chelation therapy

The chelating agent may be administered intravenously, intramuscularly, or orally, depending on the agent and the type of ... Other chelating agents have been discovered. They all function by making several chemical bonds with metal ions, thus rendering ... Other chelating agents, such as 2,3-dimercaptopropanesulfonic acid (DMPS) and alpha lipoic acid (ALA), are used in conventional ... Research in the former Soviet Union led to the introduction of DMPS, another dithiol, as a mercury-chelating agent. The Soviets ...

*Metalloprotease inhibitor

Most MMP inhibitors are chelating agents. The inhibitor binds to the zinc at the active center of the enzyme, thereby blocking ... One is a chelating moiety that interacts with the zinc ion and the other is a hydrophobic extension from the catalytic site ... In vitro, EDTA, 1,10-phenanthroline and other chelating compounds lower the concentration of metal to the point where the metal ... It is an antitumor and antiangiogenic agent with oral bioavailability. Inhibition of TACE and MMP-1 are linked to the ...

*Chelation

... therapy is the use of chelating agents to detoxify a patient's body of poisonous metal agents, such as mercury, ... Usually these ligands are organic compounds, and are called chelants, chelators, chelating agents, or sequestering agents. ... EDTA is the typical chelating agent that keeps these metal ions in a soluble form. The ligand forms a chelate complex with the ... Such chelating agents include the porphyrin rings in hemoglobin and chlorophyll. Many microbial species produce water-soluble ...

*H. Vasken Aposhian

... chelating agent 2,3-dimercapto-1-propanesulfonic acid. This method however has been proven to provide unreliable results which ... the human metabolism of chelating agents; and biochemical genetics in particular gene transfer in mammalian cells. Aposhian has ...

*Radium-223

Henriksen, G; Hoff, P; Larsen, R. H. (2002). "Evaluation of potential chelating agents for radium". Applied Radiation and ...

*Lewis acids and bases

These multidentate Lewis bases are called chelating agents. Lewis acids and bases are commonly classified according to their ...

*Podsolisation

... mor humus is produced which provides a greater amount of chelating agents. In podsolisation, chelating agents break down clay ... These organic acids are known as chelating agents. Many podsol soils form underneath coniferous forests, the fact that pine ...

*Pendetide

... (GYK-DTPA) is a chelating agent. It consists of pentetic acid (DTPA) linked to the tripeptide glycine (G) - L- ...

*Ethylenediamine

A most prominent derivative of ethylenediamine is the chelating agent EDTA, which is derived from ethylenediamine via a ... Hydroxyethylethylenediamine is another commercially significant chelating agent. Numerous bio-active compounds and drugs ... The derivative N,N-ethylenebis(stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline ... Ethylenediamine is a well-known bidentate chelating ligand for coordination compounds, with the two nitrogen atoms donating ...

*Neocuproine

... is a heterocyclic organic compound and chelating agent. Phenanthroline ligands were first published in the late ...

*Angiotensin-converting enzyme

Therefore, ACE can be inhibited by metal-chelating agents. The E384 residue was found to have a dual function. First it acts as ... are ACE inhibitors and angiotensin II type 1 receptor antagonists potential doping agents?". Sports Medicine. 38 (12): 1065-79 ...

*Transition metal alkene complex

Butadiene, cyclooctadiene, and norbornadiene are well-studied chelating agents. Trienes and even some tetraenes can bind to ...

*Pharmacodynamics

Antacids and chelating agents combine chemically in the body. Enzyme-substrate binding is a way to alter the production or ...

*Hydrometallurgy

Through the use of chelating agents, one can selectively extract certain metals. Such chelating agents are typically amines of ... Chelating agents, natural zeolite, activated carbon, resins, and liquid organics impregnated with chelating agents are all used ... The lixiviant solution conditions vary in terms of pH, oxidation-reduction potential, presence of chelating agents and ...

*Dopamine beta-hydroxylase

Townes S, Titone C, Rosenberg RC (February 1990). "Inhibition of dopamine beta-hydroxylase by bidentate chelating agents". ... "THE INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY TROPOLONE AND OTHER CHELATING AGENTS". Biochemical Pharmacology. 13 (7): 1103-6 ... amphetamine-related agents". In Lemke TL, Williams DA, Roche VF, Zito W. Foye's principles of medicinal chemistry (7th ed.). ...

*8-Hydroxyquinoline

... is a monoprotic bidentate chelating agent. In neutral solution, the hydroxyl is in the protonated form (pKa= ...

*Gadolinium(III) chloride

One representative chelating agent is H5DTPA, diethylenetriaminepentaacetic acid. Chelation to the conjugate base of this ... "Free" gadolinium(III), e.g. [GdCl2(H2O)6]+, is toxic, so chelating agents are essential for biomedical applications. Simple ... GdCl3∙6H2O can not be used as an MRI contrasting agent due to its low solubility in water at the body's near neutral pH. " ... To generate the relaxation agents, Gd3+ sources such as GdCl3∙6H2O are converted to coordination complexes. ...

*Catalyst poisoning

"Promoting Synergy in CoW Sulfide Hydrotreating Catalysts by Chelating Agents". Journal of Catalysis. 200: 194. doi:10.1006/jcat ... Agents vary their catalytic properties because of the nature of the transition metal. Ruthenium, palladium, nickel, cobalt, and ...

*Thabonithy Thayalakumaran

In Biogeochemistry of Chelating Agents, ACS Symposium Series Vol 910. Eds. Nowack, B. and J. VanBriesen, American Chemical ...

*Chelating resin

... s are a class of ion exchange resins. They are almost always used to bind cations. They utilize chelating agents ... The variation in chelating resins arises from the nature of the chelating agents pendant from the polymer backbone. Dowex ... Chelating resins operate similarly to ordinary ion exchange resins. Most chelating resins are polymers (copolymers to be ... Chelating resins have the same bead form and polymer matrix as usual ion exchangers. Their main use is for preconcentration of ...

*Band keratopathy

Topical disodium EDTA can be used as a chelating agent. Digital Reference of Ophthalmology eMedicine Template:Https://www.aao. ...

*Denticity

Polydentate ligands are chelating agents and classified by their denticity. Some atoms cannot form the maximum possible number ...

*Indium (111In) satumomab pendetide

Pendetide acts as a chelating agent for the radionuclide indium-111. García-fernández; Luna-Pérez, P.; Hernández-Hernández, D. ...

*Metalloproteinase

Treatment with chelating agents such as EDTA leads to complete inactivation. EDTA is a metal chelator that removes zinc, which ...

*List of food additives

Chelating Agent Egg - Egg yolk - Egg white - Elderberry - Eleutherococcus senticosus - Enzymatically hydrolyzed Carboxymethyl ... Flour treatment agents Flour treatment agents are added to flour to improve its color or its use in baking. Glazing agents ... Anticaking agents Anticaking agents keep powders such as milk powder from caking or sticking. Antifoaming agents Antifoaming ... anti-caking agent, firming agent Calcium polyphosphates - anti-caking agent Calcium propionate - preservative Calcium salts of ...
ABSTRACT Growth factors are thought to activate estrogen receptor-alpha ERα by phosphorylating the serines in the N-terminus of the receptor. However, this mechanism does not account for the conformational changes that occur in the ligand binding domain (LBD) of receptor to render the receptor active. It is hypothesized that epidermal growth factor (EGF) activates ERα through the PLC--calcium-calmodulin pathway by increasing intracellular calcium which, upon binding to the LBD, induces a conformational change that activates the receptor. In support of this hypothesis, treatment of MCF-7 cells with EGF (150 ng/ml) lead to an increase in intracellular calcium from 150 nM to 350 nM (+/-70 nM) and the induction of the ERα responsive genes, progesterone receptor (PgR) and pS2. The ability of EGF to induce PgR and pS2 mRNA was blocked by inhibitors of phospholipase C-, calmodulin, and calmodulin kinase II, the intracellular calcium chelator BAPTA-AM, and by an antiestrogen. Treatment with ...
Radionuclide chelating compounds are provided for conjugation to targetting molecules such as proteins, peptides or antibodies. The resulting labelled targetting molecules may be used in diagnosis and therapy.
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Chelation therapy has been used to treat atherosclerotic disease. We reported the results of an NIH-funded trial demonstrating a significant reduction of a combined cardiovascular endpoint in post-myocardial infarction (MI) patients treated with EDTA-based chelation compared with placebo. We report more detailed analyses of the effect of chelation compared to placebo on cardiovascular clinical outcomes among diabetic (DM) patients.. Methods: TACT, a multi-center, double-blind, placebo-controlled, 2 X 2 factorial trial of EDTA chelation and high-dose vitamins, enrolled 1708 pts aged ≥ 50 years with an MI at least 6 weeks prior and creatinine ≤ 2.0. Protocol prespecified a comparison of chelation with placebo in DM patients. Median duration of follow-up was 55 months. The primary endpoint was death from any cause, MI, stroke, coronary revascularization, or hospitalization for angina. The major secondary clinical endpoint was cardiovascular death, MI, or stroke. The log rank test was used for ...
Dr. Jonathan Collin is an MD specializing in adult medical care with emphasis on nutritional and alternative medicine, including EDTA Chelation Therapy.
Copper chelates of 2-hydroxybenzophenones, are long lasting UV light absorbers which may be employed to stabilized organic compositions, and particularly polymers such as polyparabanic acid, against degradation on exposure to UV light. A stabilizing amount of the chelate is incorporated in the composition or is prepared in situ from a copper salt of a weak acid and the 2-hydroxybenzophenone.
Find quality suppliers and manufacturers of 60-00-4(Ethylenediaminetetraacetic acid) for price inquiry. where to buy 60-00-4(Ethylenediaminetetraacetic acid).Also offer free database of 60-00-4(Ethylenediaminetetraacetic acid) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
82499-10-3 - IMNOEUFZITUSSY-UHFFFAOYSA-N - Purine, 6-((2-pyridylmethyl)thio)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The effects of polar (mercaptoacetyl-triseryl) and negatively charged (mercaptoacetyl-triglumatyl) chelators on the biodistribution of 99mTc-labeled anti-HER2 Affibody molecules were previously investigated. With glycine, serine, and glutamate, we de
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InterFase Plus™ provides the same unique enzyme formulation as InterFase™ with the addition of ethylenediaminetetraacetic acid (EDTA). The presence of calcium,
Genzymes sevelamer carbonate (Renvela) successfully and significantly reduced serum phosphorus for hyperphosphalemic patients who have chronic kidney disease but are not on dialysis. This was the primary end point for the study, which also showed that sevelamer carbonate significantly reduced calcium phosphorus product and low-density lipoprotein cholesterol. Sevelamer carbonate was welltolerated and exhibited a safety profile similar to sevelamer hydrochloride (Renagel). The multicenter, open-label study included 49 patients in Europe and Australia. In the United States, sevelamer hydrochloride is the most prescribed phosphate binder; sevelamer carbonate is a buffered form of sevelamer hydrochloride that is calcium-free and metal-free. Once FDA-approved, sevelamer carbonate will be available in 800-mg tablets.. ...
Looking for information on mercury and other heavy metal chelation treatments? You should know this before you consider the traditional heavy metal chelation...
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Human cytomegalovirus (HCMV)-encoded G protein-coupled-receptor US28 is believed to participate in virus dissemination through modulation of cell migration and immune evasion. US28 binds different CC chemokines and the CX3C chemokine CX3CL1. Membrane-anchored CX3CL1 is expressed by immune-activated endothelial cells, causing redirection of CX3CR1-expressing leukocytes in the blood to sites of infection. Here, we used stable transfected cell lines to examine how US28 expression affects cell migration on immobilized full-length CX3CL1, to model how HCMV-infected leukocytes interact with inflamed endothelium. We observed that US28-expressing cells migrated more than CX3CR1-expressing cells when adhering to immobilized CX3CL1. US28-induced migration was G protein-signalling dependent and was blocked by the phospholipase Cβ inhibitor U73122 and the intracellular calcium chelator BAPTA-AM. In addition, migration was inhibited in a dose-dependent manner by competition from CCL2 and CCL5, whereas CCL3 ...
Sevelamer carbonate Sandoz is a medicine available in a number of countries worldwide. A list of US medications equivalent to Sevelamer carbonate Sandoz is available on the Drugs.com website.
Juicing and Raw Foods: EDTA Chelation: The Real "Miracle" Therapy for Vascular Disease The story of EDTA chelation therapy is as much political as it is medical. Co ...
Advanced Materials Forum III: Study of the Cure of a Diglycidyl-Ether of Bisphenol-a (DGEBA) / Triethylenetetramine (TETA) Epoxy System by Non-Isothermal Differential Scanning Calorimetry (DSC)
Protection by the heavy metal chelator N,N,N,N-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) against the lethal action of botulinum neurotoxin A and B ...
In the present study, we demonstrated that H2O2 modulates the relative levels of XO and XDH in endothelial cells via a pathway requiring ER calcium release. We also showed that ROS slowly released from Menadione and SIN-1 and stimulation of endogenous ROS using angiotensin II decreased the XDH content of endothelial cells in a manner similar to bolus H2O2. H2O2 evoked a progressive decline in XDH, and our metabolic labeling studies demonstrated that this was caused by conversion of XDH to XO. This conversion resulted in increased ROS production by XO as shown by ESR analysis. The effect of H2O2 was mediated by [Ca2+]i, because it was prevented by the calcium chelator BAPTA-AM and mimicked by the calcium ionophore A23187. Further, we demonstrated that H2O2 stimulated release of calcium from the ER, and that this was prevented by thapsigargin and the IP3 receptor antagonist 2-APB. The PLC activator m-3M3FBS mimicked the effect of H2O2, in keeping with the concept that PLC activation may be a ...
The appropriate dose of L-Glutathione depends on age, health and other conditions. Recommended dosage is 50mg taken daily with meals, or as directed by a physician. For adults only. Take with food. A physician should monitor use of LGlutathione to ensure adequate levels are achieved.. L-Glutathione is also recommended to be used in conjunction with heavy metal chelation to facilitate excretion rather than redepositing mobilized toxins. This is due to heavy metal chelation mobilizing toxins and overloading filtration organs (kidney, liver). When chelation occurs too quickly, toxins can be redeposited in different organs resulting in additional damage. ...
Collagen is a dominant protein in connective tissues and highly valuable in food industry. Fish processing byproducts are good alternative source for collagen. The objective of this study was to develop a simple non-toxic method to extract crude collagen from Yellowfin tuna skin and to check functional properties of its hydrolysates. Extraction procedures were conducted using acetic acid and citric acid with 0.5 M concentrations. Based on 8% SDS-PAGE gel, type I collagens were identified. Enzymatic hydrolysis was done with Protease, Trypsin and Pepsin enzymes with different time combinations (0 h, 3 h, 6 h, 9 h, 12 h and 24 h) at 37 °C after adjusting to its optimum pH level. Best hydrolysate was selected and subjected to antioxidant activity by Diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity and Metal (Fe2+) chelating activity. Proximate analysis was conducted for raw skin to determine moisture, ash, crude protein, crude fat content and 59.44±0.013%, 1.91±0.37%, 28.55±1.19%, ...
EDTA chelation therapy is a nonsurgical treatment for heart disease. It can help you avoid heart and artery disease or could be an alternative to bypass surgery.
The human body has more than 200 different types of cells, and those cells contain more potassium than any other mineral. Best known for its work in unison with sodium to regulate fluids in and out of the body, potassium is also closely associated with proper nerve transmission and cardiac functioning. Natures Plus is committed to offering the best supplements available anywhere. Look for the Natures Plus logo as your guarantee of quality. Manufactured with the Biotron process of amino acid chelation.Potassium (as amino acid chelate - complex) - 99 mg - Microcrystalline cellulose, stearic aicd, silica and pharmaceutical glaze.
Copper-64 has been shown to dissociate from TETA and TETA-conjugates and to undergo transchelation to superoxide dismutase in rat liver in biodistribution and metabolism studies (7 , 20 , 21 , 27) . The cross-bridged cyclam, CB-TE2A, has demonstrated improved in vitro kinetic stability as well as a reduction of in vivo transchelation (25 , 27 , 38) . These studies suggest that CB-TE2A is an enhanced chelator compared with TETA for labeling 64Cu for in vivo imaging and therapy.. Similar binding affinities for SSTr prepared from AR42J tumor membranes were determined for 64Cu-TETA-Y3-TATE and 64Cu-CB-TE2A-Y3-TATE (Fig. 3)⇓ . However, there was a significant difference in the Bmax values measured for the TETA (192 fmol/mg) and CB-TE2A (1551 fmol/mg) conjugates. This might be attributed to a broader specificity for 64Cu-CB-TE2A-Y3-TATE binding to SSTr than for 64Cu-TETA-Y3-TATE. Although AR42J tumors express SSTr2, these tumor cells have also been shown to express SSTr1, SSTr3, and SSTr5 (31) . ...
Bio-Synthesis offers macrocyclic metal chelator conjugation services by covalently attached peptides, antibodies or drugs to those metal chelating ligands
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در این پژوهش اثر اسکاونجر حفره EDTA در تسریع رنگبری رنگزای آبی مستقیم 71 به‌عنوان یک آلاینده سخت تجزیه‌پذیر در فرایند فتوکاتالیستی با استفاده از نانو ذرات دی‌اکسید تیتانیوم پوشش داده شده بر بستر سیمانی بررسی شد. با استفاده از 03/0 مولار EDTA، 75 میلی‌گرم در لیتر رنگزا در pH برابر 6 ، تحت تابش لامپ UV-C 60 وات طی مدت زمان 75 دقیقه رنگبری شد. این درحالی است که رنگزا تحت این شرایط و بدون حضور اسکاونجر در مدت زمان 225 دقیقه حذف شد، به ‌این ترتیب اثر تسریع‌کنندگی این اسکاونجر تأیید شد. سینتیک فرایند فتوکاتالیستی در حضور EDTA مرتبه اول با ثابت واکنش 05/0 بر دقیقه به‌دست آمد که 5/2
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The chemistry of aqueous Ru^(II)(H_2O)_6(tos)_2(tos = p-toluene sulfonate)(1) with functionalized olefins has been investigated. Complexes of the type (H_2O)_5Ru^(II)(olefin)(tos)_2 are formed from 1 and monoolefins. Dienes such as diallyl ether and 1,5-hexadiene displace two aquo ligands from 1 to form chelate complexes of the type (H_2O)_4Ru^(II)(olefin)_2(tos)_2. Chelation of oxygen containing functionalities such as alcohols, ethers, and sulfonates has also been observed when the functional group is a specified distance from the olefin. Thus, 3-buten- 1-o1, 3-butenyl methyl ether, and 2-propenesulfonate anion form chelate complexes Ru^(II)(H_2O)_4(η^1(O): η^2(C,C)-HOCH_2CH_2CH=CH_2)(tos)_2, Ru^(II)(H_2O)4-( η^1(O): η^2(C,C)-CH_3OCH_2CH_2CH=CH_2)(tos)_2, and Ru^(II)(H_2O)_4(η^1(O): η^2(C,C)OSO_2CH_2CH=CH_2)(tos), but allyl ethyl ether forms only the olefin complex Ru^(II)(H_2O)_5(η^2(C,C)-CH_2=CHCH_2OCH_2CH_3)(tos)_2. Carboxylic acid functionalities react irreversibly with 1 to ...
Figure 4: TPEN induces activation of NF-κB, p53 and c-Jun transcription factors, caspase-3, and AIF in Jurkat T cells. Jurkat cells (1 × 106 cells/mL) were incubated with TPEN (3 μM) at 37°C for 24 hours. Untreated (a) and TPEN-treated cells were stained with anti-NF-κB-p65 (b), anti-p53 (c), anti-c-Jun (d), anti-caspase-3 (e), and anti-AIF (f) antibodies according to protocol described in according to Material and Methods section Notice that compared to control, NF-κB, p53, c-Jun, caspase-3, and AIF positive nuclei (dark brown color) reflect their nuclear translocation/activation and appear to correlate with the apoptotic nuclear morphology. Notice also that (a) represents the control for each antibody used in ((b)-(f)). Magnification 700x ((a)-(f ...
Ethylene cross-bridged cyclam with two acetate pendant arms, ECB-TE2A, is known to form the most kinetically stable 64Cu complexes. However, its usefulness as a bifunctional chelator is limited because of its harsh radiolabeling conditions. Herein, we report new cross-bridged cyclam chelator for the development of ultrastable 64Cu-radiolabeled bioconjugates. Propylene cross-bridged TE2A (PCB-TE2A) was successfully synthesized in an efficient way. The Cu(II) complex of PCB-TE2A exhibited much higher kinetic stability than ECB-TE2A in acid decomplexation studies, and also showed high resistance to reduction-mediated demetalation. Furthermore, the quantitative radiolabeling of PCB-TE2A with 64Cu was achieved under milder conditions compared to ECB-TE2A. Biodistribution studies strongly indicate that the 64Cu complexes of PCB-TE2A cleared out rapidly from the body with minimum decomplexation. © 2012 American Chemical Society. ...
Medicardium EDTA chelation suppositories are specially formulated for added health benefits. Magnesium/di-potassium EDTA helps alleviate stress, anxiety and body tension, promoting deep relaxation.
EDTA chelation therapy involves repeated administrations of a synthetic amino acid to reduce atherosclerotic plaque and other mineral deposits throughout the cardiovascular system.. Participants will be randomly assigned to receive 40 infusions of either the standard chelation solution or placebo. The primary endpoint of this trial will be a composite of all cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina.. The results of TACT will provide either a significant positive result or an informative null result upon which rational clinical decision-making and health policy can be based. ...
EDTA chelation therapy involves repeated administrations of a synthetic amino acid to reduce atherosclerotic plaque and other mineral deposits throughout the cardiovascular system.. Participants will be randomly assigned to receive 40 infusions of either the standard chelation solution or placebo. The primary endpoint of this trial will be a composite of all cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina.. The results of TACT will provide either a significant positive result or an informative null result upon which rational clinical decision-making and health policy can be based. ...
Succimer is a chelating (KEE-late-ing) agent that is used to remove a heavy metal (such as lead) from the body. Succimer binds to lead in the blood and allows it to be passed out in the urine. Succimer is used to treat lead poisoning. Succimer may also be used for purposes not listed in this medication guide.
Using the sequential injection analysis with the spectrophotometric detector, the kinetic method for the determination of cysteine was developed and validated. The kinetic method is based on redox reaction where cysteine as a reductant, reduces green copper(II) neocuproine complex to copper(I) neocuproine complex. The formated yellow-orange copper(I) neocuproine complex shows an absorption maximum at wavelength of 458 nm. The optimum parameters of the flow system were determined by a univariate method and as a result the calibration curve was constructed. Linearity was achieved for the concentration range from 6.0  10 7 mol L 1 to 8.0  10 5 mol L 1 and it was described with the equation y = 3690.4 x + 0.0019 and correlation coefficient R 2 = 0.9997. The calculated limit of detection is 1.8  10 -7 mol L -1 and the limit of quantification is 6.0  10 7 mol L 1 . The influence of foreign substances commonly found in the composition of the pharmaceutical preparations was ...
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BioAssay record AID 624075 submitted by Broad Institute: Whole cell secondary assay to determine compounds inducing growth delay in presence of metal chelator in Pseudomonas Aeruginosa PAK strain (absorbance 600nm) Measured in Whole Organism System Using Plate Reader - 2091-08_Inhibitor_Dose_DryPowder_Activity_Set4.
AAAAAWe became interested in molecular sieves because of their potential as host matrices for site isolation of homogeneous catalysts and reactive intermediates. In particular, we were intrigued with the idea that one might be able to physically trap metal complexes in the oxide pores rather than immobilize the complexes by attachment to the surface of the molecular sieve. A distinct advantage would be that a trapped complex would be free to move within the confines of the channel or cage and thereby retain some of the homogeneous properties in a microreactor. The reactivity of such ship-in-a-bottle complexes would be modified by the properties of the molecular sieve, especially shape selectivity. Therefore, molecular sieve encapsulated metal complexes might be considered a bridge between homogeneous and heterogeneous systems. Some of these ideas have been realized through the encapsulation of large chelate complexes (e.g. phthalocyanines) in large pore zeolites such as NaY or X. In recent years ...
The structure determination of the title compound was undertaken as part of a series of synthetic and structural studies of mixed-valence copper cyanide complexes containing amine bases. The coordinated amines stabilize the divalent copper atoms against reduction by the cyanide groups. In this study, the synthesis involved the linear tetradentate base triethylenetetramine (trien), under conditions expected to produce a polymeric structure, as in Williams et al. (1972); Colacio et al. (2002); Kim et al. (2005). Instead the crystal structure is made up of discrete molecules with terminal cyanide groups that are not involved in covalent polymeric linkages, and is similar to structures reported by: Yuge et al. (1998); Pickardt et al. (1999); Pretsch et al. (2005).. The molecules contain a divalent and a monovalent copper atom bridged by a cyanide group. The divalent copper atom, Cu2, shows square-pyramidal coordination, with the four N atoms of the tetradentate ligand occupying the basal positions, ...
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China amino acid chelate catalog of Calcium-Amino Acid Chelation (feed additive& fertilizer grade), Amino Acid Chelate Copper (fertilizer grade or feed grade) provided by China manufacturer - Chengdu Chelation Biology Technology Co., Ltd., page1.
The International College of Integrative Medicine is offering a grant of $20,000 to stimulate further research on chelation therapy to treat vascular disease and/or diabetic complications. The funds are to be used to plan a significant study. Applicants must submit an adequate explanation of their proposals to include 1) the likelihood of a successful outcome based on previous studies, 2) the possibilities for funding of the entire study, and 3) involvement of experienced researchers and clinicians. Proposals should be no more than 2-3 type-written pages. They can be submitted to Wendy Chappell by email. The deadline for proposals is May 31. The Grant will be called the James P. Carter Memorial Grant for EDTA Chelation Research. ...
Professional guide for Succimer. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
You can now access full text articles from research journals published by CSIR-NISCAIR! Full text facility is provided for all nineteen research journals viz. ALIS, AIR, BVAAP, IJBB, IJBT, IJCA, IJCB, IJCT, IJEB, IJEMS, IJFTR, IJMS, IJNPR, IJPAP, IJRSP, IJTK, JIPR, JSIR & JST. NOPR also hosts three Popular Science Magazines viz. Science Reporter (SR), Vigyan Pragati (VP) & Science Ki Duniya (SKD) and a Natural Products Repository (NPARR ...
Dieting may possibly cause some long-term damages to the physique if not handled effectively since it locations lots of attention to food intake, a nu
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T00446 (aalt,achr,actc,amyb,amyc,asw,cmos,cthd,dfn,fek,fva,hta,kak,kmx,kpnk,lei,lsh,lys,mcol,msub,mtab,noe,oor,paru,pje,png,ptd,rpln,sclo,sera,sfz,slb,snl,srub,taj : calculation not yet completed ...
1 Answer to CALCULATE THE THEORETICAL YIELD IN GRAMS OF TRIS(ETHYLENEDIAMINE)NIKEL(II)CHLORIDE FROM THE THIS QUESTION.(determine the limiting reactant if 1.0 g NiCl2.6H2O and 10 ml 1.0 M ethylenediamine are reacted.) - 225308
Angioprim is a liquid oral chelation method invented by Thomas Snee. Chelation is a process of removing heavy metals from the bloodstream that is also said by the makers of Angioprim to clean blockage in the arteries. Angioprim uses amino acids for its active ingredients as opposed to drug ingredients.
Looking for Calcium disodium ethylene diamine tetra-acetate? Find out information about Calcium disodium ethylene diamine tetra-acetate. see chelating agents chelating agents . Certain organic compounds are capable of forming coordinate bonds with metals through two or more atoms of the... Explanation of Calcium disodium ethylene diamine tetra-acetate
Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.
The novelty of our comprehensive study is the demonstration for the first time that a proinflammatory lipid metabolite, such as PGE2 and its receptors, plays a crucial role in herpes virus latency. Previous reports have indicated the role of Ca2+ in KSHV lytic cycle (17-20). In contrast, our studies showing the downregulation of LANA-1 expression by EP1 receptor antagonist, the blockage of supernatant-induced [Ca2+]i signal by EP1 antagonist, and the downregulation of PGE2-induced LANA-1 promoter activity by calcium chelators are the first demonstration of a role for [Ca2+]i in KSHV latency program. Unlike calcium, previous reports have shown the role of Src, PI3K, PKCζ/λ, and NF-κB in KSHV latency program (21-23). However, the novelty of our study is that the data linking PGE2/EP receptors with KSHV LANA-1 expression and LANA-1 promoter through PGE2 via Src, PI3K, PKCζ/λ, and NF-κB signal induction provides a new framework to understand the host mechanisms used by KSHV to induce these ...
Alterations in iron and copper homeostasis are a characteristic feature of diabetes, evidenced by deposition of iron and copper in heart, kidney, and other tissues (43,44). Underlying the alterations in copper homeostasis are defects in copper absorption, tissue distribution, and an increase in loosely bound (chelatable) copper in tissues (43-45). Cooper (summarized in 45) reported that, compared with control subjects, type 2 diabetic patients had higher basal urinary copper excretion and a greater increase in urinary copper in response to oral administration of triethylenetetramine, a well-tolerated copper chelator used clinically for treatment of Wilson disease. Administration of triethylenetetramine for 6 months caused a significant ∼5% reversion of left ventricular mass toward normal in type 2 diabetic patients compared with an increase of 3% in left ventricular mass in untreated patients; these changes occurred without effects on blood pressure or blood glucose concentration. Like AGE ...
The affinity of metal chelates for amino acids, such as histidine, is widely used in purifying proteins, most notably through six-histidine `tails. We have found that metal affinity interactions can also be applied to separation of single-stranded nucleic acids through interactions involving exposed purines. Here we describe a metal affinity precipitation method to resolve RNA from linear and plasmid DNA. A copper-charged copolymer of N-isopropyl acrylamide (NIPAM) and vinyl imidazole (VI) is used to purify plasmid from an alkaline lysate of E. coli. The NIPAM units confer reversible solubility on the copolymer while the imidazole chelates metal ions in a manner accessible to interaction with soluble ligands. RNA was separated from the plasmid by precipitation along with the polymer in the presence of 800 mM NaCl. Bound RNA could be recovered by elution with imidazole and separated from copolymer by a second precipitation step. RNA binding showed a strong dependence on temperature and on the ...
The process of removing heavy metals from the body is known as Chelation Therapy. Learn more about the medical procedure of chelation therapy.
The significantly increased copper and oxidative stress levels are characteristic hallmarks of cancer cells. These differences provide a unique opportunity for selective targeting of cancer cells. D-penicillamine (D-pen) has been proposed to generate reactive oxygen species (ROS) in presence of copper. Therefore, these studies were aimed at investigating the potential application of a currently marketed copper chelator, D-pen, as a novel cytotoxic anti-cancer agent. D-pen was shown to produce ROS, specifically hydrogen peroxide (H2O2), in the presence of cupric sulfate through a copper catalyzed oxidation reaction. During this process D-pen was converted to D-pen disulfide. The experimental proof of the H2O2 generation was conclusively shown with the aid of a novel High Performance Liquid Chromatography (HPLC) assay. The in-vitro cytotoxicity of D-pen co-incubated with cupric sulfate was examined in human beast cancer (MCF-7 and BT474) and leukemia cells (HL-60, HL-60/VCR, and HL-60/ADR). D-pen was
To evaluate N-hydroxyurea as zinc binding group in the design of MMP inhibitors, two peptidyl 1-hydroxyureas were prepared by N-hydroxycarbamoylation of the diastereomeric dipeptides H-Leu-Phe-NHMe and H-d-Leu-Phe-NHMe. Peptidyl 1-hydroxyureas were more potent than the parent peptides, but dramatically weaker (4-5 orders of magnitude) than the isosteric (R)-succinylhydroxamate analogue, which displays IC(50) in the range of nM vs MMP-1, -3, -7 and sub-nM vs MMP-2, -8, and -9. The peptidyl 1-hydroxyurea 1a attained an IC(50) of 20muM vs MMP-9, and substantially approaches inhibition of known N-hydroxyureas based on aminoacids or peptides against other zinc metalloenzymes and non-peptidic N-hydroxyureas against MMPs. Strong preference of the O-N1-CO unit for the antiperiplanar amide bond conformation seems to be the major limit for more effective zinc chelation. Methylation of a peptidyl 1-hydroxyurea at N3, to promote the synperiplanar O-N1-CO conformation required for zinc chelation and improve ...
Chelation is a process of removing heavy metals from the body. The intake of the metals in different forms causes problems which can only be treated by the removal of these heavy metals from the body. During the world war, most of the people suffered due to the ingestion of lead. This ingestion of the foreign particles composed of metals such as lead creates problem at a later stage. Chelation is used to remove these toxic metals from the body. Chelation uses chemicals that can make these toxins amalgamate and settle. The amalgamated metals are then thrown out of the body. There are several Chelation methods that are used for this process. One of the methods, which are known as oral Chelation involves the consumption of chemicals orally that can make the metals settle in the body. One chemical that is commonly used is EDTA. EDTA Chelation is one of the most efficient ways of removing the toxins from the body. Chelation is also used to prevent the contraction of the arteries due the presence of ...
Several researchers have developed a modified way to do intravenous chelation therapy. This has come about from a better understanding of how chelation works. The standard method, which has been used since the 1940s on many thousands of patients, is still a good method. The new method uses a calcium EDTA that can be infused faster and works well to remove heavy toxic metals, including mercury, lead, arsenic, nickel, and cadmium. All of these are fairly commonly found in todays toxic environment. So far, studies seem to indicate that it is just as good to clean out arterial plaque as the older method. It does not, however, have the long track record as the older method.. If only the calcium EDTA is used, it is safe to infuse in as little as one minute for most people. However, many feel a major benefit of the chelation process is to include some vitamins and minerals with it as is done in the older method. Thus we include these in a 100 ml bag (rather than 250 or 500) and infuse it in ...
Other research has yielded some information about the possible mechanisms of EDTA in the body. A study published in Free Radical Biology and Medicine (Hininger et al., 2005) investigated whether the large doses of vitamin C (an antioxidant) typically administered with EDTA therapy might actually have a prooxidant effect. The researchers gave two different groups of subjects EDTA with and without 5 g vitamin C and found that indeed the biochemical measurements of free radicals were markedly increased soon after therapy in the vitamin C group compared to the group that did not receive vitamin C. However, over the course of 16 treatments, the researchers found that despite the prooxidant activity directly following each treatment, the long-term effects were antioxidant. They suggested that this therapy might be beneficial to patients with heart disease and diabetes because the long term effects involved protection against lipid peroxidation. They also noted that [t]he effects of multiple sessions ...
ADDITIONAL COMMENTS - Preliminary estimation: It was difficult to accurately determine a preliminary estimation of the solubility of the product, due to the limitations in seeing droplets of a clear liquid in water. A visual estimated solubility of 2.5 mg/L was observed. Consequently a saturated solution was prepared and filtered through a 0.1 μm syringe filter to give a clear liquid. This solution was analysed by HPLC using a single point calibration to give a concentration of approximately 40 mg/mL. This was noticeably greater than the visual estimation of 2.5 mg/mL. The saturated solution was prepared using a concentration of 4.1 g/100 mL. At this concentration the majority of the test material did not dissolve. - Observations during preparation: The three day saturated solution was prepared by transferring 4.1 g of the test material into a 250 mL screw topped conical flask and adding 100 mL of water. The flask was shaken at 150 rpm. After 24 and 48 hours additional flasks were added to the ...
Global (North America, Europe and Asia-Pacific, South America, Middle East and Africa) Copper Paste Market 2018 Forecast to 2023. COPPER PASTE is a high temperature anti-seize lubricant. A soft, copper-coloured paste, based on micronized copper powder and synergistic anti-oxidant, anti-corrosion and anti-wear additives suspended in premium grade stable oil. It is an effective anti-seize formulation, preventing metal-to-metal contact, seizing, galling, and fretting corrosion. Scope of the Report: This report focuses on .... February 2018 , $4880 ,View Details>> ...
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Chelation therapy involves the administration of chelating agents to treat toxic metal poisoning. These chelating agents or chelants are used to remove heavy metals from the body in cases of overdose, poisoning or accumulation. The chelants are ligands that bind to metals present in the blood and tissues.
Radiometric dating methods are the strongest direct evidence that geologists have The half-life of a radioactive nuclide is defined as the time it takes half of a 8 months of dating and no i love you ervaringen Resources › Physical Sciences Resources › Radiometric Dating Shortcomings of a dating method in current use are not generally acknowledged by evolutionists. It means that there is no such thing as a legitimate evolutionary fossil A modern archaeologist has almost half a dozen natural dating techniques that she provided J Louis Giddings with a means of ordering sites chronologically. Stratigraphy is not an absolute dating technique as the best it can do is allow for dating 24 year old woman translocation of Al and Fe by means of mobile chelate complexes. This process is linked and two absolute dating techniques to establish a better methodology.Radiometric dating is used to estimate the age of rocks and other objects based on the fixed Radiometric Dating: Methods, Uses & the ...
Looking for online definition of chelators in the Medical Dictionary? chelators explanation free. What is chelators? Meaning of chelators medical term. What does chelators mean?
The CSV is a delimited data format that has fields/columns separated by the semicolon character and records/rows separated by newlines. Fields that may contain a special character (semicolon, newline, or double quote), are enclosed in double quotes. For an easier handling, the list of Pre-registered substances is available in four parts ordered by EC number. They contain the same information as the following full list.. ...
Sequestering agents are added to maintain clarity and to promote calculus removal. Preferred sequestering agents include ethylene diamine tetraacetic acid ("EDTA"). The EDTA may be present in amounts of above 1% to 25% by weight of the composition, preferably about 17% to about 23% by weight of the composition, and most preferably about 19% to 21% by weight of the composition. EDTA also plays a role as an anti-bacterial component.. Surfactant ...
Few side effects occur when chelating agents are administered for approved indications using the recommended dosage and route of administration.
Angioprim is an effective method in cleaning blocked arteries and veins. Plaque prevention promotes a healthy cardiovascular system and can lead to a healthier, longer life. Its powerful chelating action helps remove plaque from the arteries quicker.
Hello doctor. Im a long-term cardiac patient who has been invited (by my cardiologist)to participate in clinical study of chelation therapy. Would you please give me an overview of this therapy? Spe...
See chelation therapy reviews from people who are using Detoxamin. Detoxamin will revolutionize medicine Dr Sherry Rogers. Read chelation therapy reviews.
The main results of the present study is that BKChs are tightly colocalized with voltage-gated Ca2+ channels such that Ca2+ ions have to diffuse, on average, only ∼13 nm after entering the cell before they bind to BKChs. The operation of BKChs by nanodomains of single Ca2+ channels provides several unique advantages, as discussed below. This functional colocalization was determined by a novel approach based on a linear approximation of buffered Ca2+ diffusion in microdomains (Neher, 1986; Stern, 1992; Naraghi, 1997).. This approach involved the quantitative analysis of the effect of the Ca2+ chelator BAPTA on the repolarization phase of action potentials, which we have shown to be potently shaped by BKChs. When we plotted the ln-transformed normalized local Ca2+ versus the inverse buffer length constant (1/λ), the points could be well fitted with a line through the origin and a slope of 12.7 nm. Because our approach involves a calibration of the Ca2+-dependent response (action potential ...
[110 Pages Report] Check for Discount on Global Chromium Chelate Supplements Market Professional Survey Report 2017 report by QYResearch Group. This report studies Chromium Chelate Supplements in Global market, especially...
Benefits of intravenous chelation include reductions in the risk of a cardiovascular event, death from heart disease, a nonfatal stroke or a heart attack by more than 40 percent, and a 52 percent...
Looking for the webs Top Celation Sites? Top20Sites.com is the leading directory of popular Oral Chelation, Detoxification Products, Celation, & Home Chelation sites.
Help I want to read this, but it is hard to follow as it is too long for the page!! That second link is the full paper, the first link is just the abstract and request to pay for the ...
Heres something that I find to be most disturbing! http://www.webmd.com/vitamins-supplements/ingredientmono-1032-EDTA.aspx?activeIngredientId=1032&activeIngredientName=EDTA EDTA Other Names: Ac...
Forty-one patients (18 male and 23 female) between the ages of 6 and 54 with a diagnosis of Wilsons disease and who were intolerant of d-penicillamine were treated in two separate studies with trientine hydrochloride. The dosage varied from 450 mg to 2,400 mg per day. The average dosage required to achieve an optimal clinical response varied between 1,000 mg and 2,000 mg per day. The mean duration of trientine hydrochloride therapy was 48.7 months (range 2 months to 164 months). Thirty-four of the 41 patients improved, 4 had no change in clinical global response, 2 were lost to follow-up and one showed deterioration in clinical condition. One of the patients who improved while on therapy with trientine hydrochloride experienced a recurrence of the symptoms of systemic lupus erythematosus which had appeared originally during therapy with penicillamine. Therapy with trientine hydrochloride was discontinued. No other adverse reactions, except iron deficiency, were noted among any of these 41 ...
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... Information for Physicians. AnazaoHealth, Nuclear Medicine Division, can precisely compound Sn-Dimercaptosuccinic Acid freeze-dried kits on your order. We can ship to you overnight.. AnazaoHealth has been compounding Sn-Dimercaptosuccinic Acid Kits for the Preparation of TC-99m-DMSA on prescription.. Please contact AnazaoHealth for information about these products.. ...
... Information for Physicians. AnazaoHealth, Nuclear Medicine Division, can precisely compound Sn-Dimercaptosuccinic Acid freeze-dried kits on your order. We can ship to you overnight.. AnazaoHealth has been compounding Sn-Dimercaptosuccinic Acid Kits for the Preparation of TC-99m-DMSA on prescription.. Please contact AnazaoHealth for information about these products.. ...
Benefits of Chelation Therapy. Cancer Treatment. Free radicals plays an important role on the onset of cancer. By removing the metallic anions from the blood stream, EDTA helps the cells to remain healthy and to help the damaged cells to heal. Some research has shown a decrease in the incidence of death by cancer after EDTA treatment.
Trientine used combination - Can zinc and trientine be used in combination? Yes. Trientine is used in wilsons disease (a rare copper storage disease) to chelate (bind) copper. Zinc is a trace element, dietary supplement with many alleged benefits that are unproved except in zinc deficiency. There is no reported interaction between the two.
Triethylenetetramine [TETA (trientine); Supplemental Fig. 1] is an alternative drug for Wilsons disease if the patient becomes intolerant to the primary medication with penicillamine (Walshe, 1969). TETA is a very efficient copper chelator and very well tolerated. However, it is rapidly metabolized to its mono (MAT)- and diacetylated (DAT) derivatives (Lu et al., 2007). Recently, TETA has also shown potency in the treatment of other diseases such as diabetes-associated end-organ damage (Cooper, 2011), cancer (Yin et al., 2003), and Alzheimers disease (Cooper, 2011).. TETA resembles the biogenic polyamine spermidine (Spd) in structure (Supplemental Fig. 1), but possesses only about +2 net charge at the physiologic pH compared with +3 that of Spd (Bencini et al., 1999; Frassineti et al., 2003). The polyamines Spd and spermine (Spm) are present at high concentrations in almost all cell types and are considered mediators of important cellular functions such as proliferation, differentiation, and ...
The primary health problem affecting the arteries is arteriosclerosis. An artery is comprised of three basic layers: an inner layer known as the intima, a middle layer called the media, and an outer layer known as the adventitia. In some cases of arteriosclerosis yellowish plaques, called atheromas, develop within the intima and medial layers of the larger arteries. These plaques contain cholesterol, fatty materials, proteins and minerals. Another form of arteriosclerosis occurs when deposits of calcium develop within the media of the larger arteries. Chelation therapy works by attacking the calcium deposits in the arteries. Calcium exists in the body in many forms. Calcium in the bones and teeth is firmly bound to protein and other molecules and is not easily removed by chelation. Calcium in the blood may be bound in part by protein or in a readily available ionic form. This ionic level of calcium is rigidly controlled by the parathyroid gland. Chelation works by removing calcium from the blood ...
The invention provides lanthanide chelates capable of intense luminescence. The celates comprise a lanthanide chelator covalently joined to a coumarin-like or quinolone-like sensitizer. Exemplary sensitzers include 2- or 4-quinolones, 2- or 4-coumarins, or derivatives thereof e.g. carbostyril 124 (7-amino-4-methyl-2-quinolone), coumarin 120 (7-amino-4-methyl-2-coumarin), coumarin 124 (7-amino-4-(trifluoromethyl)-2-coumarin), aminomethyltrimethylpsoralen, etc. The chelates form high affinity complexes with lanthanides, such as terbium or europium, through chelator groups, such as DTPA. The chelates may be coupled to a wide variety of compounds to create specific labels, probes, diagnostic and/or therapeutic reagents, etc. The chelates find particular use in resonance energy transfer between chelate-lanthanide complexes and another luminescent agent, often a fluorescent non-metal based resonance energy acceptor. The methods provide useful information about the structure, conformation, relative location
Ballal NV, Tweeny A, Baumgartner JC, Ginjupalli K, Saraswathin V. Effect of maleic acid and theylenediaminetetraacetic acid on the shear bond strenth of RealSeal SE sealer to root canal dentin. Eur J Prosthodont Restor Dent. 2013;21(4):152-6.. Centers for Disease Control and Prevention (CDC). Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. MMWR Morb Mortal Wkly Rep. 2006;55(8):204-7.. Chappell LT. Should EDTA chelation therapy be used instead of long-term clopidogrel plus aspirin to treat patients at risk from drug-eluting stents? Altern Med Rev. 2007 Jun;12(2):152-8. Review.. Escolar E, Lamas GA, Mark DB, et al. The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT). Circ cardiovasc Qual Outcomes. 2014;7(1):15-24.. Evans DAP, Tariq M, Sujata B, McCAnn G, Sobki S. The effects of magnesium sulphate and EDTA in the hypercholesterolaemic ...
Methods for treatment of humans and other animals with dimercaptosuccinic acid (DMSA). DMSA is administered to reduce levels of silicon in blood and tissue, reduce blood pressure, improve kidney function, prevent or retard the progression of chronic renal failure, treat the accumulation of silicon in advanced kidney disease, decrease accumulation of reactive oxygen metabolites, increase superoxide dismutase activity, and/or prevent the onset or improve the current status of senile dementia or Alzheimers disease.
... Deferiprone is a recently introduced orally active iron chelator which has simplified the treatment of transfusion siderosis in thalassemia patients. Oral desferrioxamine is poorly absorbed when given

Chelating Agents | Encyclopedia.comChelating Agents | Encyclopedia.com

chelating agents (kē´lātĬng). Certain organic compounds are capable of forming coordinate bonds (see chemical bond [1]) with ... metals through two or more atoms of the organic compound; such organic compounds are called chelating agents. ... chelating agent (kee-layt-ing) n. a chemical compound that forms complexes by binding metal ions. Some chelating agents, ... The compound formed by a chelating agent and a metal is called a chelate. A chelating agent that has two coordinating atoms is ...
more infohttps://www.encyclopedia.com/science-and-technology/chemistry/organic-chemistry/chelating-agents

Chelating Agents - ICD CodesChelating Agents - ICD Codes

View list of generic drugs that are classified under Chelating Agents along with ICD Code. Find related prescribing information ... This medication is a chelating agent, prescribed for thalassaemia.. Edetate. This medication is a chelating agent, prescribed ...
more infohttps://www.medindia.net/drugs/icd-codes/chelating-agents.htm

Chelating agent | chemistry | Britannica.comChelating agent | chemistry | Britannica.com

Processing agents: Chelating, or sequestering, agents protect food products from many enzymatic reactions that promote ... These agents bind to many of the minerals that are present in food (e.g., calcium and magnesium) and are required as cofactors ... Other articles where Chelating agent is discussed: food additive: ... In food additive: Processing agents. Chelating, or sequestering, agents protect food products from many enzymatic reactions ...
more infohttps://www.britannica.com/science/chelating-agent

Chelating agents | SpringerLinkChelating agents | SpringerLink

Chelating agents. Renal phosphate leak due to elevated fibroblast growth factor-23: case report ...
more infohttps://link.springer.com/article/10.1007%2Fs40278-019-56251-6

Mercury Toxicity Medication: Chelating Agents, Gastrointestinal DecontaminantsMercury Toxicity Medication: Chelating Agents, Gastrointestinal Decontaminants

L-penicillamine have been used as chelating agents in the treatment of mercury toxicity. Use chelating agents if the patient is ... Chelating Agents. Class Summary. These agents are used to help remove a portion of the bodys mercury stores. They are ... Chelating agents should be administered early in treatment.. GI decontamination may be useful only in acute, recent ingestions ... Chelating agents are thought to use their thiol groups to compete with sulfhydryl groups in binding methyl mercury. The ...
more infohttps://emedicine.medscape.com/article/1175560-medication

Global Chelating Agents Market Report Review, 2016-2020: ReportstackGlobal Chelating Agents Market Report Review, 2016-2020: Reportstack

Report Outline: Chelating agents, also called chelants, sequestering agents, or complexing agents, form stable complexes after ... For detailed report with TOC, please click here ​Global Chelating Agents Market 2016-2020. ... Chelating agents are primarily used for the following purposes: • To eliminate metal ions that might affect the effectiveness ... Market Growth: The global chelating agent market is expected to grow at a CAGR of 4.27% during the period 2016-2020. ...
more infohttps://pitchengine.com/pitches/9b4f127d-ab50-492f-8b72-4dd0c98d5561

Chelating agents with lipophilic carriers - Patent # 7727512 - PatentGeniusChelating agents with lipophilic carriers - Patent # 7727512 - PatentGenius

Aparticularly preferred chelating agent in the compounds of the invention is DOTA.. The purpose of the chelating agent is, of ... 5,804,164 describes water-soluble, lipophilic agents which comprise particularly designed chelating agents and paramagnetic ... an ancillary component such as a fluorophore or chelating agent and reactive moieties for coupling to the targeting agent;the ... emulsions which contain both targeting agent and a chelating agent but wherein the metal to be chelated is either suppliedin ...
more infohttp://www.patentgenius.com/patent/7727512.html

Calcium Chelating Agents, Calcium Chelating Agents Suppliers and Manufacturers at Alibaba.comCalcium Chelating Agents, Calcium Chelating Agents Suppliers and Manufacturers at Alibaba.com

High Quality Calcium Chelating Agents Products from Global Calcium Chelating Agents Suppliers and Calcium Chelating Agents ... agent penetrating agent water repellent agent stiffening agent calcium chelating agents supplier calcium chelating agents ... Tags: Chelating Agents , Calcium Chelating Agents , Chelating Agents With Special Effect , View larger image ... Chelating Dispersing Agent Muanfacturer , Textile Calcium Chelating Agents Manufacturer , Chemical Calcium Chelating Agents ...
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Macrocyclics, chelating agents for medical applications.Macrocyclics, chelating agents for medical applications.

Macrocyclics, Inc., a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation ... Providing tools and solutions in the field of nuclear medicine for site-specific bioconjugation, advanced chelating agent ...
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Global Natural Chelating Agents Sales Market Report 2017 : ReportsnReportsGlobal Natural Chelating Agents Sales Market Report 2017 : ReportsnReports

In this report, the global Natural Chelating Agents market is... ... Check for Discount on Global Natural Chelating Agents Sales ... Global Natural Chelating Agents Sales Market Report 2017 Table of Contents. Global Natural Chelating Agents Sales Market Report ... 2.2 Global Natural Chelating Agents (Volume and Value) by Type. 2.2.1 Global Natural Chelating Agents Sales and Market Share by ... 4.3 China Natural Chelating Agents Sales Volume and Market Share by Type. 4.4 China Natural Chelating Agents Sales Volume and ...
more infohttp://www.reportsnreports.com/reports/1179884-global-natural-chelating-agents-sales-market-report-2017.html

China Formaldehyde Based Chelating Agent Market Research Report 2017 : ReportsnReportsChina Formaldehyde Based Chelating Agent Market Research Report 2017 : ReportsnReports

The global Formaldehyde Based Chelating Agent market is valued at... ... 100 Pages Report] Check for Discount on China Formaldehyde Based Chelating Agent Market Research Report 2017 report by ... 1 Formaldehyde Based Chelating Agent Overview. 1.1 Product Overview and Scope of Formaldehyde Based Chelating Agent. 1.2 ... 7 Formaldehyde Based Chelating Agent Manufacturing Cost Analysis. 7.1 Formaldehyde Based Chelating Agent Key Raw Materials ...
more infohttp://www.reportsnreports.com/reports/1249870-china-formaldehyde-based-chelating-agent-market-research-report-2017.html

Webinar - Chelating Agent Market  by End-use Industry - Global Forecast 2021 | MarketsandMarketsWebinar - Chelating Agent Market by End-use Industry - Global Forecast 2021 | MarketsandMarkets

HOME › Chelating Agent Market by Type (Aminopolycarboxylate, Phosphates & Phosphonates), by End-use Industry (Pulp & Paper, ... Chelating Agent Market by Type (Aminopolycarboxylate, Phosphates & Phosphonates), by End-use Industry (Pulp & Paper, Water ... MarketsandMarkets will host webinar to help you uncover the high growth opportunities in Chelating Agent Market. Our industry ... Which applications/end-user segments are showing wider adoption of Chelating Agent Market? ...
more infohttps://www.marketsandmarkets.com/Webinar.asp?id=110316150

3-hydroxy-2(1H)-pyridinone chelating agents - Energy Innovation Portal
	3-hydroxy-2(1H)-pyridinone chelating agents - Energy Innovation Portal

These chelating agents incorporate within their structure 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted ... In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with the adjacent HOPO oxygen ... Disclosed is a series of improved chelating agents and the chelates formed from these agents, which are highly effective upon ... Disclosed is a series of improved chelating agents and the chelates formed from these agents, which are highly effective upon ...
more infohttp://techportal.eere.energy.gov/patent.do/ID=10017

Scleroderma Medication: Corticosteroids, Immunosuppressive agents, Pulmonary, Tyrosine Kinase Inhibitors, Endothelin receptor...Scleroderma Medication: Corticosteroids, Immunosuppressive agents, Pulmonary, Tyrosine Kinase Inhibitors, Endothelin receptor...

Chelating agents. Class Summary. These agents may improve the fibrotic aspects of systemic sclerosis. ... Immunosuppressive agents. Class Summary. These agents inhibit key steps in immune reactions. ... As an alkylating agent, the mechanism of action of the active metabolites may involve cross-linking of DNA, which may interfere ... These agents bind to endothelin receptors present in endothelium and vascular smooth muscle cells. The effect can result in ...
more infohttps://emedicine.medscape.com/article/331864-medication

Chelating Agents Market Demand Is Expected To Reach 1,348.4 kilo tons By 2024, Growing At A CAGR of 3.1% From 2016 to 2024:...Chelating Agents Market Demand Is Expected To Reach 1,348.4 kilo tons By 2024, Growing At A CAGR of 3.1% From 2016 to 2024:...

Increasing requirement for chelating agents in cleaners& detergents to boost the performance of the finished product is ... The global chelating agents market is expected to reach USD 5.17 billion by 2024, according to a new report by Grand View ... The global chelating agents market is expected to reach USD 5.17 billion by 2024, according to a new report by Grand View ... Global chelating agents size was 1,026.0 kilo tons in 2015 and is expected to reach 1,348.4 kilo tons by 2024, growing at a ...
more infohttps://www.cnbc.com/2016/06/14/globe-newswire-chelating-agents-market-demand-is-expected-to-reach-13484-kilo-tons-by-2024-growing-at-a-cagr-of-31-from-2016-to-2024-grand.html

Molecules | Free Full-Text | New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in...Molecules | Free Full-Text | New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in...

New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in Oncology. Anna Lucia ... "New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in Oncology." Molecules 22, no. 8 ... New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in Oncology. Molecules. 2017; 22( ... New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in Oncology. Molecules 2017, 22, ...
more infohttps://www.mdpi.com/1420-3049/22/8/1282

Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells by activation of the p38 MAPK pathway.Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells by activation of the p38 MAPK pathway.

Cu-chelating agent, inhibits tumor growth in a murine transplantation model using fibrosarcoma and induces apoptosis in tumor ... Chelating Agents / pharmacology*. Copper / metabolism. Enzyme Activation. Fibrosarcoma / enzymology*. Imidazoles / pharmacology ... 0/Chelating Agents; 0/Imidazoles; 0/Pyridines; 0/SB 203580; 112-24-3/Triethylenetetramine; 7440-50-8/Copper; EC 2.7.11.24/p38 ... We have reported that treatment with trientine, Cu-chelating agent, inhibits tumor growth in a murine transplantation model ...
more infohttp://www.biomedsearch.com/nih/Trientine-Copper-Chelating-Agent-Induced/19959910.html

Chelating agents and the environment. - Semantic ScholarChelating agents and the environment. - Semantic Scholar

The behavior of chelating agents in the environment has received considerable attention for more than 50 years now. EDTA ( ... This increase has been mainly due to the proposed use of chelating agents for soil remediation, both for extraction of metals ... 1). The research on anthropogenic chelating agents in the environment started in 1950 with a publication on the effect of EDTA ... Since the middle of the 1990s the research on chelating agents in the environment has increased dramatically. ...
more infohttps://www.semanticscholar.org/paper/Chelating-agents-and-the-environment.-Nowack/d02fbb79b3dd87df0622677e7eca6dd61b28bf6f

Olfactory dysfunction in beta-thalassemia major patients treated with iron-chelating agents | Ear, Nose & Throat JournalOlfactory dysfunction in beta-thalassemia major patients treated with iron-chelating agents | Ear, Nose & Throat Journal

The use of iron-chelating agents by patients with BTM and their duration of use were recorded, as well as hemoglobin and ... Olfactory dysfunction can occur in patients with BTM treated with iron-chelating agents. The results suggest that screening for ... Olfactory dysfunction in beta-thalassemia major patients treated with iron-chelating agents ... treated regularly with blood transfusions and iron-chelating agents. We hypothesized that olfactory dysfunction may be present ...
more infohttps://www.entjournal.com/article/olfactory-dysfunction-beta-thalassemia-major-patients-treated-iron-chelating-agents

A potentiometric detection technique for chelating agents after separation by capillary zone electrophoresis  - Open Access...A potentiometric detection technique for chelating agents after separation by capillary zone electrophoresis - Open Access...

Capillary electrophoresis; Potentiometric detection; Chelating agents; Aminopolycarboxylic acids.. Journal or Publication Title ... A potentiometric detection technique for chelating agents after separation by capillary zone electrophoresis ... A potentiometric detection technique for chelating agents after separation by capillary zone electrophoresis , Monatshefte fur ... potential depends on the concentration of copper ions at the electrode surface and therefore decreases when chelating agents ...
more infohttps://eprints.utas.edu.au/8002/

Some Iron Parameters Among Transfusion-dependent Subjects In Maiduguri, Nigeria: The Case For Provision Of Chelating Agents In...Some Iron Parameters Among Transfusion-dependent Subjects In Maiduguri, Nigeria: The Case For Provision Of Chelating Agents In...

Some iron parameters among transfusion-dependent subjects in Maiduguri, Nigeria: The case for provision of chelating agents in ... There may be need to routinely provide iron chelating treatment and supplementation of vitamin A, B5 and E for transfusion- ...
more infohttps://www.omicsonline.org/proceedings/some-iron-parameters-among-transfusiondependent-subjects-in-maiduguri-nigeria-the-case-for-provision-of-chelating-agents-64885.html

Industrial Cleaning Market by Ingredient (Chelating Agents, Solvents, Surfactants, pH regulators), by Application ...Industrial Cleaning Market by Ingredient (Chelating Agents, Solvents, Surfactants, pH regulators), by Application ...

7.2.1 Chelating Agents. 7.2.2 PH Regulators. 7.2.3 Solubilizers/Hydrotropes. 7.2.4 Solvents. 7.2.5 Surfactants. 7.2.5.1 Anionic ... Table 6 Chelating Agents : I&I Cleaning Chemicals Market Size, By Application, 2013-2020 (USD Million). Table 7 PH Regulators ... Product: Industrial Cleaning Market by Ingredient (Chelating Agents, Solvents, Surfactants, pH regulators), by Application ( ... Industrial Cleaning Market by Ingredient (Chelating Agents, Solvents, Surfactants, pH regulators), by Application ( ...
more infohttps://www.researchandmarkets.com/reports/3627408/industrial-cleaning-market-by-ingredient

OCULAR ABNORMALITIES IN CHILDERN WITH B THALASSEMIA MAJOR AND VISUAL TOXICITY OF IRON CHELATING AGENTS  for Abd Almottleb Hala...OCULAR ABNORMALITIES IN CHILDERN WITH B THALASSEMIA MAJOR AND VISUAL TOXICITY OF IRON CHELATING AGENTS for Abd Almottleb Hala...

OCULAR ABNORMALITIES IN CHILDERN WITH B THALASSEMIA MAJOR AND VISUAL TOXICITY OF IRON CHELATING AGENTS for Abd Almottleb Hala ... OCULAR ABNORMALITIES IN CHILDERN WITH B THALASSEMIA MAJOR AND VISUAL TOXICITY OF IRON CHELATING AGENTS for Abd Almottleb Hala ... OCULAR ABNORMALITIES IN CHILDERN WITH B THALASSEMIA MAJOR AND VISUAL TOXICITY OF IRON CHELATING AGENTS for Abd Almottleb Hala ... OCULAR ABNORMALITIES IN CHILDERN WITH B THALASSEMIA MAJOR AND VISUAL TOXICITY OF IRON CHELATING AGENTS for Abd Almottleb Hala ...
more infohttp://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/94107-engb-94107

Iron Chelating Agents | GreenMedInfo | Pharmacological ActionIron Chelating Agents | GreenMedInfo | Pharmacological Action

Pharmacological Actions : Antioxidant, Iron Chelating Agents, Neuroprotective Agents, Regenerative. Additional Keywords : Nerve ... Pharmacological Actions : Iron Chelating Agents, Neuroprotective Agents, Regenerative. Additional Keywords : Nerve Regeneration ... Pharmacological Actions : Anti-Apoptotic, Iron Chelating Agents, Neuroprotective Agents, Superoxide Dismutase Up-regulation ... 15 Abstracts with Iron Chelating Agents Research. Filter by Study Type. Animal Study. ...
more infohttp://video.greenmedinfo.com/pharmacological-action/iron-chelating-agents

The Role of the Chelating Agent on the Structure and Anticorrosion Performances of an Organosilane-Zirconium Sol-Gel CoatingsThe Role of the Chelating Agent on the Structure and Anticorrosion Performances of an Organosilane-Zirconium Sol-Gel Coatings

The structure and reactivity of the ZC were modified by varying the content of methacrylic acid employed as a chelating agent. ... Here, the structure of the ZC was modified by addition of a chelating agent employed in different concentrations to form a ZC ... The structure and reactivity of the ZC were modified by varying the content of methacrylic acid employed as a chelating agent. ... This work aimed at identifying the effect of the chelating agent on the structure and anticorrosion properties of hybrid sol- ...
more infohttp://file.scirp.org/Html/1-1510613_82720.htm
  • The global market for chelating agents is growing due to the growth of the chemicals industry. (pitchengine.com)
  • In September 2015, ChemPoint EMEA B.V, a company engaged in sales marketing and distribution of specialty chemicals announced that it was expanding its marketing and distribution relationship with The Dow Chemical Company by providing formulation, sales and order fulfillment support for the company's VERSENE which is food grade chelating agent and used in food applications. (cnbc.com)
  • This report studies the Formaldehyde Based Chelating Agent development status and future trend in China, focuses on top players in China, also splits Formaldehyde Based Chelating Agent by type and by applications, to fully and deeply research and reveal the market general situation and future forecast. (reportsnreports.com)
  • Pharmaceutical is anticipated to be a potential market for chelating agents over the forecast period on account of increasing government spending on providing primary healthcare facilities to its citizens. (cnbc.com)
  • Macrocyclics, Inc., a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation chemistry platforms critical for advancement of diagnostic and therapeutic medicine. (macrocyclics.com)
  • Chelating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with the adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. (energy.gov)
  • Polar anionic metabolome analysis by nano-LC/MS with a metal chelating agent. (semanticscholar.org)
  • The antiviral actions of a number of compounds (e.g., thiosemicarbazones, pyrophosphate analogues, beta-diketones, cyclic polyethers and flavanoids) are discussed in the light of their metal-chelating properties. (phoenixrising.me)
  • For the most common forms of heavy metal intoxication - lead, arsenic, or mercury - a number of chelating agents are available. (wikipedia.org)
  • Chelating agents are important in textile dyeing, water softening, and enzyme deactivation and as bacteriocides. (encyclopedia.com)
  • Degradation of chelating agents in aqueous solution using advanced oxidation process (AOP). (semanticscholar.org)
  • The global chelating agents market is expected to reach USD 5.17 billion by 2024, according to a new report by Grand View Research, Inc. Increasing requirement for chelating agents in cleaners & detergents to boost the performance of the finished product is expected to drive growth. (cnbc.com)
  • According to the results, it has not been fully elucidated whether the chelating activity of glyphosate contributes to the toxic effects on plants and potentially on plant-microorganism interactions, e.g., nitrogen fixation of leguminous plants. (paperity.org)
  • It is also still open whether the chelating property of glyphosate is involved in the toxic effects on organisms other than plants, described in many papers. (paperity.org)
  • Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. (wikipedia.org)
  • Chelating, or sequestering, agents protect food products from many enzymatic reactions that promote deterioration during processing and storage. (britannica.com)
  • This factor has resulted in increasing production volumes of various manufacturers of chelating agents. (cnbc.com)
  • Since the work of Schwarzenbach in 1949, phosphonic acids are known as effective chelating agents. (wikipedia.org)
  • Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (uchicago.edu)
  • clarification needed] There are a variety of common chelating agents with differing affinities for different metals, physical characteristics, and biological mechanism of action. (wikipedia.org)
  • Following this approach, we evaluated the anti-tat and anti-HIV-1 activity of several sulfhydryl compounds with chelating properties. (phoenixrising.me)
  • In the process of reevaluation of glyphosate its chelating activity has hardly been discussed. (paperity.org)
  • Providing tools and solutions in the field of nuclear medicine for site-specific bioconjugation, advanced chelating agent technology, and peptide intermediates. (macrocyclics.com)
  • We have reported that treatment with trientine, Cu-chelating agent, inhibits tumor growth in a murine transplantation model using fibrosarcoma and induces apoptosis in tumor cells in vivo and in vitro. (biomedsearch.com)
  • Exposurein vitro of various mammalian retroviruses to the chelating agents EDTA or EGTA in millimolar concentrations resulted in partial disintegration of viral membranes as measured by accessibility or even release of reverse transcriptase, an internal viral protein, without any other treatment usually required. (phoenixrising.me)
  • Cumulative number of publications about the use and the effects of chelating agents in the environment, beginning with the first publication in 1950 until end of 2006. (semanticscholar.org)