Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.Areca: A plant genus of the family ARECACEAE. Members contain ARECOLINE and CATECHIN. The leaves and nuts have been used as masticatories, stimulants, and astringents in traditional medicine. The common name of betel is also used for PIPER BETLE. The common name of catechu is sometimes used for ACACIA CATECHU.DiazomethaneNicotinic Acids: 2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.Cholinergic Agonists: Drugs that bind to and activate cholinergic receptors.Parasympathomimetics: Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.Benzylisoquinolines: ISOQUINOLINES with a benzyl substituent.Oral Submucous FibrosisEchinococcosis: An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Epithelial-Mesenchymal Transition: Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Gingiva: Oral tissue surrounding and attached to TEETH.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)Cystathionine gamma-Lyase: A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.Cystathionine beta-Synthase: A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Garcinia cambogia: A plant species of the family CLUSIACEAE. It is a source of hydroxycitric acid.Garcinia mangostana: A plant genus of the family CLUSIACEAE. It is the source of the mangosteen fruit.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.EncyclopediasMotor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Amphetamine-Related Disorders: Disorders related or resulting from use of amphetamines.Adipates: Derivatives of adipic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,6-carboxy terminated aliphatic structure.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Crack Cocaine: The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.Atropine Derivatives: Analogs and derivatives of atropine.Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Muscarinic Agonists: Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Nuts: Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.Mastication: The act and process of chewing and grinding food in the mouth.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.KB Cells: This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Government Agencies: Administrative units of government responsible for policy making and management of governmental activities.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Arecoline Anatoxin-a Scheidweiler, KB; Plessinger, MA; Shojaie, J; Wood, RW; Kwong, TC (Dec 2003). "Pharmacokinetics and ...
Arecoline, an alkaloid present in the Betel nut. Pilocarpine is a drug that acts as a muscarinic receptor agonist that is used ...
The lime in the betel quid [areca nut, lime and Piper betle leaves] causes hydrolysis of arecoline to arecailide, a central ... Liu YJ, Peng W, Hu MB, Xu M, Wu CJ (November 2016). "The pharmacology, toxicology and potential applications of arecoline: a ... The major parasympathetic and muscarinic effects of areca nut are due to arecoline. Sharan RN, Mehrotra R, Choudhury Y, Asotra ... Pilocarpine, arecoline and muscarine are rather selective parasympathetic agents; i.e., their cholinomimetic activity is ...
Although novel ways to produce these compound exist, background stems from arecoline chemistry. E.g. Paxil and femoxetine also ...
Biologically, these effects may be a consequence of the arecoline that is found in areca nuts. The habit also exposes the fetus ... Various compounds present in the nut, most importantly arecoline (the primary psychoactive ingredient which is similar to ... and three main alkaloids-arecoline, arecaidine, and guvacine-all of which have vasoconstricting properties. The betel leaf ...
The seed contains alkaloids such as arecaidine and arecoline, which, when chewed, are intoxicating and slightly addictive. ...
The tetrazole alvameline (8), for example, was developed as a bioisostere of the muscarinic cholinergic compound arecoline. The ... "Bioisosteres of Arecoline: 1,2,3,6-Tetrahydro-5-pyridyl-Substituted and 3-Piperidyl-Substituted Derivatives of Tetrazoles and 1 ... in which the position of the double bond mimics that in arecoline. Reaction of (3) with ethyl chloroformate results in N- ...
"Muscarinic receptor 1 agonist activity of novel N-arylthioureas substituted 3-morpholino arecoline derivatives in Alzheimer's ...
The preparation of Paxil from arecoline is an application of this reaction, as well as the synthesis of GSK-372,475, for ...
... is a piperidine based stimulant drug which is synthesised from arecoline. It is similar to nocaine in chemical structure, and ...
R. ferrugineum is moderately toxic, containing arbutin, arecoline and rhodoxanthin, and can cause vomiting, and difficulties of ...
... or with some difficulty ante mortem by purging with arecoline hydrobromate. Detection of antigens in feces by ELISA is ...
... which are comprise arecoline, arecolodine, arecaidine, guvacine, isoguvacine, and govacolidine; the pharmacological and other ...
... arecoline MeSH D03.066.515.375 --- clonixin MeSH D03.066.515.400 --- etazolate MeSH D03.066.515.475 --- niacin MeSH D03.066. ... arecoline MeSH D03.383.725.547.375 --- clonixin MeSH D03.383.725.547.400 --- etazolate MeSH D03.383.725.547.475 --- niacin MeSH ...
... such as salicylic acid in willow bark or arecoline in areca nuts), because the word ingredient in many minds connotes a sense ...
... caffeine and arecoline in breast milk" (PDF), Rapid Communications in Mass Spectrometry, 21 (16): 2693-2703, doi:10.1002/rcm. ...
... arecoline Rauvolfia serpentina: rauwolscine yohimbe (Pausinystalia yohimbe): yohimbine, corynantheidine probably many others ...
Plant alkaloids Arecoline Nicotine Muscarine Pilocarpine (M3 receptors) Indirect acting parasympathomimetic drugs may be either ...
Tobacco, as well as arecoline and cannabis, two other plant neurotoxins that are widely used as recreational drugs in humans, ...
... powdered snail shell and betel nut/arecoline which is used as a chewing gum to the Ifugaos) is an indelible practice during the ...
... is a base, and its conjugate acid has a pKa ~ 6.8. Arecoline is volatile in steam, miscible with most organic ... Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has ... arecoline•HBr, forms slender prisms, mp. 177-179 °C from hot alcohol; the aurichloride, arecoline•HAuCl4, is an oil, but the ... "Arecoline M1 receptor activation is a requirement for arecoline analgesia". Farmaco. 56 (5-7): 383-5. doi:10.1016/S0014-827X(01 ...
InChI=1S/C26H37NO3/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3/t23-/m1/s1 ...
In the US, "yohimbe" preparations are sold as a dietary supplements for enhancing libido, for weight loss and as aids for bodybuilding; but "There is virtually no published research on yohimbe which supports these or any other claims".[9]:861 Often, these products explicitly claim to contain yohimbine.[8] Cohen et al. found that samples of brands sold in American brick-and-mortar stores contained highly variable amounts of yohimbine, and sometimes none at all.[8]:368 Labelling claims were often misleading.[8]:368 Similar results have been reported by other laboratories for products sold in the U.S., in other countries and on the internet.[15][16][17][18][19] One study found that many brands of "yohimbe" might not derive from the P. johimbe tree in the first place.[20] According to yet another source the yohimbe sold in markets in West Africa, where the tree grows, is frequently adulterated with other species of the genus Pausinystalia; these contain little yohimbine.[21] The amounts of alkaloid ...
Ji, Jianguo; Bunnelle, William H.; Anderson, David J.; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K.; Rueter, Lynne E.; Curzon, Peter; Buckley, Michael J.; Marsh, Kennan C.; Kempf-Grote, Anita; Meyer, Michael D. (2007). "A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253-1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775 ...
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100% Pure Natural Areca Catechu Extract Arecoline Powder FOB Price: US $20 / kilogram Min. Order: 1 kilogram ...
Arecoline is a base, and its conjugate acid has a pKa ~ 6.8. Arecoline is volatile in steam, miscible with most organic ... Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has ... arecoline•HBr, forms slender prisms, mp. 177-179 °C from hot alcohol; the aurichloride, arecoline•HAuCl4, is an oil, but the ... "Arecoline M1 receptor activation is a requirement for arecoline analgesia". Farmaco. 56 (5-7): 383-5. doi:10.1016/S0014-827X(01 ...
... base; Methyl N-methyl-1,2,5,6-tetrahydronicotinate; Methylarecaidine; Methyl 1,2,5,6-tetrahydro-1-methylnicotinate; N ...
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic ... Arecoline (Arecolin). Subscribe to New Research on Arecoline An alkaloid obtained from the betel nut (Areca catechu), fruit of ... 01/01/2010 - "However, few reports exist as to the effects of arecoline in human tissues other than oral cancer cell lines. ". ... 07/01/2008 - "The time between arecoline injection and time of onset of the tremor in the controls and Mg-deficient rats were ...
The effect of the central cholinolytic benactyzine and the cholinomimetic arecoline on the uptake of45Ca by rat brain ... whereas arecoline led to a rapid initial increase in45Ca uptake. Benactyzine was shown to depress the effect of arecoline and ... Semenov, E.V. Effect of benactyzine and arecoline on the45Ca uptake by rat brain nerve endings. Bull Exp Biol Med 86, 1168-1170 ... Effect of benactyzine and arecoline on the45Ca uptake by rat brain nerve endings. *E. V. Semenov ...
where to buy 131448-17-4(Arecoline-d5 Hydrobromide Salt).Also offer free database of 131448-17-4(Arecoline-d5 Hydrobromide Salt ... Arecoline-d5 Hydrobromide Salt) for price inquiry. ... ARECOLINE-D5, HYDROBROMIDE SALT;NSC 56321-d5;Arecaidine-d5; ...
Caution! Arecoline is a possible carcinogen and is biologically active!**,/span,,/div,,/strong,,br /,. Arecoline is an alkaloid ... Though of topic, while we are on topic of arecoline, I might just as well attach the chapter on arecoline analogues and their ... Synthesis of Arecoline - 3 Steps from Nicotinic Acid. ,div style="text-align: center;",,span style="color: Red;",. **Caution! ... Arecoline is a muscarinic acetylcholine M1 and M2 receptor agonist, and has generated moderate interest in academic research ...
Effects of arecoline on miR-203, SFRP4 and TM4SF1 in the HaCaT cells. To further analyze the effects of arecoline on miR-203, ... Arecoline affects the expression of EMT-related genes in a dose-dependent manner. To determine the effects of arecoline on EMT ... To detect the effect of arecoline on EMT, the HaCaT cells were treated with arecoline (Selleck Chemicals, Houston, TX, USA) at ... we validated that arecoline induced EMT in the HaCaT cells. We found that arecoline significantly decreased the expression of ...
... www.iarc.fr/news-events/iarc-monographs-evaluation-of-the-carcinogenicity-of-acrolein-crotonaldehyde-and-arecoline/ ... Arecoline, which has a mild psychoactive effect, was also classified as possibly carcinogenic to humans (Group 2B). Arecoline ... The International Agency for Research on Cancer evaluates carcinogenicity of acrolein, crotonaldehyde, and arecoline ...
... caffeine and arecoline in breast milk, using N-ethylnorcotinine as internal standard. Li … ... Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. Kuo TM, Luo SY, Chiang ... Caffeine and Arecoline in Breast Milk Manuela Pellegrini 1 , Emilia Marchei, Silvia Rossi, Federica Vagnarelli, Abhilasha ... Quantification of arecoline (areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography/ ...
Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and ... abolished the restoration of ACh-induced EDVR by high dose arecoline. On the contrary, treatment with high dose arecoline ... Conclusion: Arecoline treatment improves ACh-induced EDVR in high fructose-fed rats, and the potential mechanism of action ... Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and ...
The Arecoline freebase was prepared by treating the Arecoline Hydrobromide of commerce with concentrated aqueous sodium ... Arecoline Hydrobromide is a fairly cheap commercial starting material, $80/50g from Aldrich. Also, I think that it is used in ... Synthesis of Cocaine analogs from Arecoline. Written by Beagle, edited by Rhodium [ Back to the Chemistry Archive ] ... To a solution of 166ml of 1M 4-chlorophenylmagnesium bromide in 700ml ether was added 12.9g of arecoline freebase in 300ml ...
Arecoline is a cancer-causing compound found in betel nut / areca nut, similar to the nicotine in tobacco. Does it belong in ... In response, heres a more complete list of studies demonstrating the extremely toxic potential of arecoline:. *Arecoline- ... Arecoline, Arecoline Hydrobromide, Betel Nut, Blackstone Labs, Bodybuilding.com, Cancer, Carcinogen, Driven Sports, Insane Labz ... Arecoline hydrobromide in supplements. This is what youre looking out for on the label. ArcoFuel is labeled as "Betelnut Palm ...
The [email protected] Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access ...
Arecoline (CAS 300-8-3) is a covalent inhibitor of ACAT1. It is an agonist at muscarinic acetylcholine receptors M1 - M5. It ... Arecoline HBr , ACAT1 inhibitor Arecoline (CAS 300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 ... Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic ... 3) Christie et al. (1981), Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia; Br. J ...
... indicating the neurotoxic role of arecoline to PC12 cells. In addition, arecoline also increased the expression of Bax (pro- ... were also reduced by arecoline treatment. These results indicate that arecoline-caused neurotoxicity to PC12 cells is involved ... Simultaneously, arecoline caused excessive ER stress in PC12 cells, as evidenced by the up-regulations of Glucose-regulated ... Although arecoline-induced neurotoxicity has been reported, the possible underlying neurotoxic mechanisms have not yet been ...
Buy bulk arecoline with CAS#300-08-3 which is an alkaloid from betel nut (Areca catechu) InChIKey=AXOJRQLKMVSHHZ-UHFFFAOYSA-N ... 500mg of Arecoline HBr. Not available to UK customers and other countries where scheduled. Review the laws in your country ...
Thread: Arecoline: Full Information (CNS Stimulant,ect.). by Estopell Replies. 270. Views. 19,750. ...
The active ingredient, arecoline, is contained in the areca nut or betel nut (the nut of the palm Areca catechu ), which is cut ...
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Français : Un alkaloïde est une molécule organique à base dazote et possédant des effets pharmacologiques sur lêtre humain et sur dautres animaux ...
The basic aim of our study was to elucidate the mechanism underlying the action of arecoline on the expression of genes in oral ... Furthermore, arecoline down-regulated the expression of collagens 1A1 and 3A1 in human primary gingival fibroblasts; however ... Results: We observed the induction of transforming growth factor-beta2 by arecoline in HaCaT cells and this induction was found ... However, the molecular basis of the action of arecoline in the pathogenesis of oral submucous fibrosis is poorly understood. ...
Arecoline Anatoxin-a Scheidweiler, KB; Plessinger, MA; Shojaie, J; Wood, RW; Kwong, TC (Dec 2003). "Pharmacokinetics and ...
Arecoline, therefore, appears to be a compound suitable to selectively evaluate the responsiveness of the central component of ... Arecoline, injected iv to catheterized, freely moving male Sprague-Dawley rats, stimulated plasma ACTH and corticosterone ... These data suggest that the muscarinic cholinergic agonist arecoline stimulates the HPA axis in the rat and that this effect is ... This hypothesis was confirmed by the dose-dependent ability of arecoline to cause hypothalamic CRH secretion in vitro, an ...
Exposure to arecoline (,0.2 mM) for 24 h induced G 2/M cell cycle arrest of OMF and KB cells. Areca nut extract (,400 μg/ml) ... Exposure to arecoline (,0.2 mM) for 24 h induced G 2/M cell cycle arrest of OMF and KB cells. Areca nut extract (,400 μg/ml) ... Exposure to arecoline (,0.2 mM) for 24 h induced G 2/M cell cycle arrest of OMF and KB cells. Areca nut extract (,400 μg/ml) ... Exposure to arecoline (,0.2 mM) for 24 h induced G 2/M cell cycle arrest of OMF and KB cells. Areca nut extract (,400 μg/ml) ...
  • A procedure based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) is described for the determination of nicotine and its principal metabolites cotinine, trans-3-hydroxycotinine and cotinine-N-oxide, caffeine and arecoline in breast milk, using N-ethylnorcotinine as internal standard. (nih.gov)
  • Liquid/liquid extraction with chloroform/isopropanol (95:5, v/v) was used for nicotine, cotinine, trans-3-hydroxycotinine, cotinine-N-oxide and caffeine under neutral conditions and for arecoline under basic conditions. (nih.gov)
  • Limits of quantification were 5 microg/L for nicotine, cotinine, trans-3-hydroxycotinine, cotinine-N-oxide and caffeine, and 50 microg/L for arecoline using 1 mL human milk per assay. (nih.gov)
  • But to give you an idea of where we're going here, the arecoline in betel nut is akin to the nicotine in tobacco - both in terms of the benefits and the nasty side effects. (priceplow.com)
  • They discovered that arecoline stimulates the same brain cell receptors responsible for nicotine addiction but doesn't stimulate the other types of nicotine receptors. (newswise.com)
  • Arecoline is known to be a partial agonist of muscarinic acetylcholine M1, M2, M3 receptors and M4, which is believed to be the primary cause of its parasympathetic effects (such as pupillary constriction, bronchial constriction, etc. (wikipedia.org)
  • Arecoline is a muscarinic acetylcholine M1 and M2 receptor agonist, and has generated moderate interest in academic research for use in Alzheimer's and other neurodegenerative conditions, though its application is hindered by the compound's reported carcinogenicity ( see Wikipedia ). (sciencemadness.org)
  • Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. 1 Agonist at muscarinic acetylcholine receptors M1 - M5 (EC 50 in the range of 7-410 nM). (focusbiomolecules.com)
  • reported that PPI was significantly decreased in rats treated chronically with N -aminodeanol, a cholinergic false precursor, and a choline-free diet and that the muscarinic receptor agonist arecoline partially reversed the observed deficits in PPI. (aspetjournals.org)
  • Since one of the hallmarks of Alzheimer's disease is a cognitive decline, arecoline was suggested as a treatment to slow down this process and arecoline administered intravenously did indeed show modest verbal and spatial memory improvement in Alzheimer's patients, though due to arecoline's possible carcinogenic properties, it is not the first drug of choice for this degenerative disease. (wikipedia.org)
  • [ 16 ] In one study, arecoline was found to elevate the mRNA and protein expression of cystatin C, a nonglycosylated basic protein consistently up-regulated in a variety of fibrotic diseases, in a dose-dependent manner in persons with oral submucous fibrosis. (medscape.com)
  • To a solution of 166ml of 1M 4-chlorophenylmagnesium bromide in 700ml ether was added 12.9g of arecoline freebase in 300ml ether at -10°C. The mix was stirred at -10°C for 30 min, poured onto ice and treated with 200ml of 10% HCl. (designer-drug.com)
  • Pretreatment of the aortic rings rings from high fructose-fed rats with the CSE inhibitor propargylglycine (10 mmol/L) or the ATP-sensitive potassium (K ATP ) channel blocker glibenclamide (10 mmol/L) abolished the restoration of ACh-induced EDVR by high dose arecoline. (chinaphar.com)
  • Arecoline (CAS 300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC 50 =11.1 μM). (focusbiomolecules.com)
  • Here, the purpose of present study was to verify whether ER stress and the disturbance of endogenous H2S generation are also involved in arecoline-caused neurotoxicity. (semanticscholar.org)
  • Notably, the level of H2S in the culture supernatant and the expressions of cystathionine β-synthase and 3-mercaptopyruvate sulfurtransferase (two major enzymes for endogenous H2S generation in PC12 cells) were also reduced by arecoline treatment. (semanticscholar.org)
  • These results indicate that arecoline-caused neurotoxicity to PC12 cells is involved in ER stress and disturbance of endogenous H2S generation and suggest that the modulation of ER stress and endogenous H2S generation may be potential therapeutic approach in treatment of arecoline-caused neurotoxicity. (semanticscholar.org)
  • The main starting material used by the authors is Arecoline (3,4-unsaturated N-methyl-piperidine-3-carboxylic acid methyl ester), the active principle of the popular red betel nut. (designer-drug.com)
  • The authors start with arecoline (the active compound in betel nut: N-methyl-piperidine- 3-carboxylic acid methyl ester with a double bond between the 3 and 4 positions). (designer-drug.com)
  • Arecoline, injected iv to catheterized, freely moving male Sprague-Dawley rats, stimulated plasma ACTH and corticosterone release in a dose-dependent fashion. (euc.ac.cy)