Chalcones
Acyltransferases
Intramolecular Lyases
Kava
Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots.
Phenylalanine Ammonia-Lyase
Anthocyanins
Humulus
Zingiberaceae
Plants
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
Pterocarpans
Tetrathionic Acid
Phloroglucinol
Elaeagnaceae
Plant Proteins
Plants, Medicinal
Soybeans
Mallotus Plant
Rosales
Trans-Cinnamate 4-Monooxygenase
Fabaceae
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Ammonia-Lyases
Gene Expression Regulation, Plant
Alpinia
Apiaceae
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
Viola
Helichrysum
Isomerases
Coumaric Acids
Agaricales
Asteraceae
A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.
Plant Extracts
Molecular Structure
Gefarnate
Quercetin
Arabidopsis
Base Sequence
Plants, Genetically Modified
Amino Acid Sequence
Alcohol Oxidoreductases
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Cloning, Molecular
Inhibitory Concentration 50
RNA, Plant
Seeds
Gene Expression Regulation, Enzymologic
Lycopersicon esculentum
Structure-Activity Relationship
Biosynthetic Pathways
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Isoflavones
Plant Roots
Enzyme Induction
Monophenol Monooxygenase
Melanins
Catalysis
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Immunochemistry
Fungi
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Genetic Engineering
Substrate Specificity
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Sequence Homology, Amino Acid
Tobacco
Chromatography, High Pressure Liquid
Drug Screening Assays, Antitumor
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Models, Molecular
Models, Chemical
Antineoplastic Agents, Phytogenic
Promoter Regions, Genetic
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Mutagenesis, Site-Directed
Cell Survival
Evolution, Molecular
Sequence Homology, Nucleic Acid
Sequence Analysis, DNA
Plant Leaves
Binding Sites
DNA, Complementary
Arabidopsis Proteins
Dose-Response Relationship, Drug
Magnetic Resonance Spectroscopy
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Phenotype
Mutation
Isoenzymes
Transcription, Genetic
Cells, Cultured
Enzyme Inhibitors
Blotting, Western
Crystallography, X-Ray
Chromatography, Gel
Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (1/163)
2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs. (+info)Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (2/163)
The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions. (+info)Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages. (3/163)
In a previous work, we tested a series of chalcone derivatives as possible anti-inflammatory compounds. We now investigate the effects of three of those compounds, CHI, CH8 and CH12, on nitric oxide and prostanoid generation in mouse peritoneal macrophages stimulated with lipopolysaccharide and in the mouse air pouch injected with zymosan, where they showed a dose-dependent inhibition with inhibitory concentration 50% values in the microM range. This effect was not the consequence of a direct inhibitory action on enzyme activities. Our results demonstrated that chalcone derivatives inhibited de novo inducible nitric oxide synthase and cyclooxygenase-2 synthesis, being a novel therapeutic approach for inflammatory diseases. (+info)The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. (4/163)
Our previous studies have shown that licochalcone A, an oxygenated chalcone, has antileishmanial and antimalarial activities, and alters the ultrastructure and function of the mitochondria of Leishmania spp. parasites. The present study was designed to investigate the antileishmanial activity and the mechanism of action of a group of new oxygenated chalcones. The tested oxygenated chalcones inhibited the in-vitro growth of Leishmania major promastigotes and Leishmania donovani amastigotes. Treatment of hamsters infected with L. donovani with intraperitoneal administration of two oxygenated chalcones resulted in a significant reduction of parasite load in the liver and the spleen compared with untreated control animals. The oxygenated chalcones also inhibited the respiration of the parasite and the activity of mitochondrial dehydrogenases. Electron microscopic studies illustrated that they altered the ultrastructure of the mitochondria of L. major promastigote. The data clearly indicate that this group of oxygenated chalcones has a strong antileishmanial activity and might be developed into a new antileishmanial drug. The antileishmanial activity of oxygenated chalcones might be the result of interference with function of the parasite mitochondria. (+info)Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. (5/163)
Cytochrome P-450-derived epoxyeicosatrienoic acids (EETs) are avidly incorporated into and released from endothelial phospholipids, a process that results in potentiation of endothelium-dependent relaxation. EETs are also rapidly converted by epoxide hydrolases to dihydroxyeicosatrienoic acid (DHETs), which are incorporated into phospholipids to a lesser extent than EETs. We hypothesized that epoxide hydrolases functionally regulate EET incorporation into endothelial phospholipids. Porcine coronary artery endothelial cells were treated with an epoxide hydrolase inhibitor, 4-phenylchalcone oxide (4-PCO, 20 micromol/l), before being incubated with (3)H-labeled 14,15-EET (14,15-[(3)H]EET). 4-PCO blocked conversion of 14,15-[(3)H]EET to 14,15-[(3)H]DHET and doubled the amount of radiolabeled products incorporated into cell lipids, with >80% contained in phospholipids. Moreover, pretreatment with 4-PCO before incubation with 14,15-[(3)H]EET enhanced A-23187-induced release of radiolabeled products into the medium. In contrast, 4-PCO did not alter uptake, distribution, or release of [(3)H]arachidonic acid. In porcine coronary arteries, 4-PCO augmented 14,15-EET-induced potentiation of endothelium-dependent relaxation to bradykinin. These data suggest that epoxide hydrolases may play a role in regulating EET incorporation into phospholipids, thereby modulating endothelial function in the coronary vasculature. (+info)2'-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha- and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells. (6/163)
Inhibition of expression of cell adhesion molecules (CAM), including intercellular CAM-1 (ICAM-1), vascular CAM-1 (VCAM-1), and E-selectin, has been shown to be important in controlling various inflammatory diseases. The cell adhesion proteins are induced by various inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1, and bacterial lipopolysaccharide. The induction process primarily takes place at the level of transcription, where nuclear factor-kappaB (NF-kappaB) plays a major role. We demonstrate here that 2'-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner. The inhibition by 2'-hydroxychalcone is reversible. 2'-hydroxychalcone inhibits the induction of steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin by tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction, and therefore it may interfere with the transcription of their genes. Because NF-kappaB is a major transcription factor involved in CAM expression, we studied its status in the 2'-hydroxychalcone treated cells. We demonstrate that 2'-hydroxychalcone inhibits the activation of NF-kappaB. These results have implications for using NF-kappaB inhibitors for the treatment of various inflammatory diseases. (+info)Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L. (7/163)
The flavonoid constituents in fresh florets of the three distinctive cultivars of Carthamus tinctorius L. were purified and identified to investigate flavonoid biosynthesis in the petals. From the orange flower of cv. Kenba (K.), four new compounds, anhydrosafflor yellow B (1), two kaempferols, 9 and 13, and a quercetin, 17, were isolated, as well as the twelve known compounds, and their structures were determined by spectral data, chemical reactions, and molecular mechanics calculations. From the yellow flower of cv. Ogon-hanagasa (O.), two flavonols and two quinochalcones, and from the white flower of cv. Shiro-bana (S.), three flavonois were isolated. These compounds were the same as those contained in cv. K. To compare the flavonoid constituents among the three cultivars, crude extracts were analyzed by a LC/PDA/MS system. In cv. K., six quinochalcones and eleven flavonols were identified. In cv. O., three quinochalcones and nine flavonols were identified, but the red pigment, carthamin (4), and its precursor, precarthamin (3), were not detected. In cv. S., four flavonols without a 6-hydroxyl group were identified. On the basis of a comparative study on the constituents among these three cultivars, a possible biosynthetic pathway to form quinochalcones via the intermediate, pentahydroxychalcone (19), is proposed. (+info)Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions. (8/163)
Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, obtained by alkaline hydrogenation of neohesperidin. In this investigation a supposed taste enhancing effect of this substance was tested. A three-step procedure was used. In the first experiment, using a pool of 31 subjects, NHDC and sucrose detection thresholds were measured. In the second experiment, psychophysical functions for both tastants were determined. Then, 15 participants closest to the group threshold who, in addition, had produced monotonic psychophysical taste functions were selected to participate in the next two experiments. In the third experiment, taste enhancement was tested. Three psychophysical sucrose functions were constructed, one with a near-threshold amount of NHDC added to each of seven sucrose concentrations, one with a near-threshold amount of sucrose added (control 1) and one without any addition (control 2). No difference was found between the NHDC-enriched sucrose function and the sucrose-enriched sucrose function. Finally, in experiment 4, differential threshold functions were constructed with either NHDC or sucrose added. Neither the overall shape of the functions nor a comparison of the points of subjective equality showed enhancement. It was concluded that weak NHDC does not enhance the taste of aqueous sucrose solutions. (+info)
Computer-aided Design of Chalcone Derivatives as Lead Compounds Targeting Acetylcholinesterase - E-JURNAL
2-Hydroxychalcone | Anticancer Agent | MedChemExpress
Chana dips on low demand - The Hindu BusinessLine
Targets
Chana Dal Dealers in Anantapur | chana dal Suppliers & Manufacturer List | IndianYellowPages
Second Harmonic Generation in Some Donor-Acceptor Substituted Chalcone Derivatives
Calories of Chana Dal Paratha, Is Chana Dal Paratha healthy?
Frontiers | Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral...
Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell...
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Publications Jag Chana
Sofalcone | CAS 64506-49-6 | SCBT - Santa Cruz Biotechnology
Hiding and unveiling trans-chalcone in a constrained derivative of 4′,7-dihydroxyflavylium in water: a versatile photochromic...
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Jessi Moreno
Breit family
Hydroxysafflor Yellow A Attenuates Renal Ischemia- Reperfusion Injury in a Rat Model | Bentham Science
Integrated metabolomics and transcriptome analysis on flavonoid biosynthesis in safflower ( Carthamus tinctorius L.) under MeJA...
IJMS | Free Full-Text | Determination of Mineral Content in Methanolic Safflower (Carthamus tinctorius L.) Seed Extract and Its...
IJMS | Free Full-Text | Determination of Mineral Content in Methanolic Safflower (Carthamus tinctorius L.) Seed Extract and Its...
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HUMİK ASİT UYGULAMA ZAMANI ve DOZLARININ ASPİR (Carthamus tinctorius L.)DE VERİM, VERİM ÖĞELERİ VE YAĞ ORANINA ETKİSİ | Ankara...
Flavokawain B, a kava those muscles contract with Oxidative oppositely. | Mission for Me
Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones
Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones
澳門大學學者庫(UM): Hierarchical identification of bioactive components in a medicinal herb by preparative high-performance liquid...
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flavokawain B (CHEBI:65899)
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Gravy / Sauces
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Chalconoid
Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. In aurones, the ... Chalcone synthase is an enzyme responsible for the production of chalconoids in plants. Chalcone isomerase is responsible for ... Chalcones are also natural aromatase inhibitors. Chalcones are aromatic ketones with two phenyl rings that are also ... Chalconoids Greek: χαλκός khalkós, "copper", due to its color), also known as chalcones, are natural phenols related to ...
Phytosteroid
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
Dietary fiber
Many molecules that are considered to be "dietary fiber" are so because humans lack the necessary enzymes to split the glycosidic bond and they reach the large intestine. Many foods contain varying types of dietary fibers, all of which contribute to health in different ways. Dietary fibers make three primary contributions: bulking, viscosity and fermentation.[49] Different fibers have different effects, suggesting that a variety of dietary fibers contribute to overall health. Some fibers contribute through one primary mechanism. For instance, cellulose and wheat bran provide excellent bulking effects, but are minimally fermented. Alternatively, many dietary fibers can contribute to health through more than one of these mechanisms. For instance, psyllium provides bulking as well as viscosity. Bulking fibers can be soluble (i.e., psyllium) or insoluble (i.e., cellulose and hemicellulose). They absorb water and can significantly increase stool weight and regularity. Most bulking fibers are not ...
Naturally occurring phenols
In soils, it is assumed that larger amounts of phenols are released from decomposing plant litter rather than from throughfall in any natural plant community.[citation needed] Decomposition of dead plant material causes complex organic compounds to be slowly oxidized lignin-like humus or to break down into simpler forms (sugars and amino sugars, aliphatic and phenolic organic acids), which are further transformed into microbial biomass (microbial humus) or are reorganized, and further oxidized, into humic assemblages (fulvic and humic acids), which bind to clay minerals and metal hydroxides.[citation needed] There has been a long debate about the ability of plants to uptake humic substances from their root systems and to metabolize them.[citation needed] There is now a consensus about how humus plays a hormonal role rather than simply a nutritional role in plant physiology.[citation needed] In the soil, soluble phenols face four different fates. They might be degraded and mineralized as a carbon ...
Butein
... is a chalcone of the chalconoids. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua), Dahlia, ...
Bioisostere
Another example are chalcones bioisosteres. By modifying certain substituents, the pharmacological activity of the chalcone and ... Comprehensive Pharmacy Review, 6th edition, Leon Shargel, Alan H. Mutnick, p.264 Gomes, Marcelo N. (2017). "Chalcone ...
Sophoradin
Synthesis of Isoprenyl Chalcone "Sophoradin" Isolated from Sophora subprostrata. Kazuaki Kyogoku, Katsuo Hatayama, Sadakazu ...
Pisatin
Kimura, Y.; Aoki, T.; Ayabe, S. (2001). "Chalcone isomerase isozymes with different substrate specificities towards 6′-hydroxy ... "An overexpression of chalcone reductase of Pueraria montana var. lobata alters biosynthesis of anthocyanin and 5′- ...
Curcumin synthase
Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP (2001). "Structure and mechanism of chalcone synthase- ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Natural Product ...
Ketoacyl synthase
Chalcone synthase (E.C. 2.3.1.74), also known as naringenin-chalcone synthase, is responsible for the reaction: 3 malonyl-CoA ... Both chalcone synthases and stilbene synthases will catalyze the same acyl transfer, decarboxylation, and condensation steps as ... These enzymes are normally classified as either chalcone synthases, stilbene synthases, or type III PKSs. Overall, there are 10 ... However, they will also further cyclize and aromatize the reactions before the final chalcone product is formed. ...
Dihydrochalcone
... (DHC) is a chemical compound related to chalcone. Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′- ...
Quercetin
Tetrahydroxychalcone is then converted into naringenin using chalcone isomerase. Naringenin is converted into eriodictyol using ...
Dactylorhiza
doi:10.1111/j.1095-8339.2011.01198.x. Inda, Luis A.; Pimentel, Manuel & Chase, Mark W. (2010). "Chalcone synthase variation and ...
Apigenin
Chalcone isomerase (CHI) then isomerizes the product to close the pyrone ring to make naringenin. Finally, a flavanone synthase ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Natural Product ... Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive ... condensations of three equivalents of malonyl CoA followed by aromatization to convert p-coumaroyl-CoA to chalcone. ...
Isoliquiritigenin 2'-O-methyltransferase
Other names in common use include chalcone OMT, and CHMT. Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification ...
Ingrid del Carmen Montes González
"Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium saltderivatives" Inorg. Chim. Acta; 2017 ... "Electrochemical and Spectroscopical Characterization of Ferrocenyl Chalcones" Journal of The Electrochemical Society, 2010, 157 ... "Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium salt derivatives". Inorganica Chimica Acta ... "Electrochemical and Spectroscopical Characterization of Ferrocenyl Chalcones". Journal of the Electrochemical Society. 157 (8 ...
Trochodendraceae
Epicuticular waxes are basically composed of nonacosan-10-ol.[citation needed] Tetracentron contains chalcones or ...
Chemogenetics
... as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on ... Forkmann G, Dangelmayr B (June 1980). "Genetic control of chalcone isomerase activity in flowers of Dianthus caryophyllus". ...
Monoamine oxidase B
"Chalcones: a valid scaffold for monoamine oxidases inhibitors". J. Med. Chem. 52 (9): 2818-24. doi:10.1021/jm801590u. PMID ... Substituted chalcones 2-(N-Methyl-N-benzylaminomethyl)-1H-pyrrole 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine 2 ...
Bidens pilosa
The plant contains the chalcone okanin and ethyl caffeate, a hydroxycinnamic acid. Extracts of B. pilosa suppressed the growth ...
Aureusidin synthase
In order to modify the chalcone to an aurone, the chalcone must undergo an oxidative cyclization to form a five-member ... and the oxidative cyclization of chalcones to form aurones. The chalcones modified are typically glucosylated 2',4,4',6'- ... This step may not proceed unless the 3-position on the chalcone's B-ring is oxygenated. From this and the protein's homology ... In vitro studies have shown that aurone synthesis proceeds much more quickly when the chalcone is first glucosylated, and in ...
Lipase inhibitors
Some active compounds with chalcone scaffold found in Glycyrrhiza glabra, Cassia mimosoides, Glycyrrhiza uralensis, ... "Efficacy of chalcone and xanthine derivatives on lipase inhibition: A systematic review". Chemical Biology & Drug Design. 95 (2 ...
Daidzein
... which enzymes chalcone synthase (CHS) and chalcone reductase (CHR) modify to obtain trihydroxychalcone. CHR is NADPH dependent ... Chalcone isomerase (CHI) then isomerizes trihydroxychalcone to liquiritigenin, the precursor to daidzein. A radical mechanism ...
Anthochlor pigments
On the one hand, the hydroxytypes of chalcones and aurones, on the other hand the deoxy-types of chalcones and their ... The key to the process is the enzyme chalcone synthase (CHS), which catalyzes the formation of a hydroxyl chalcone from three ... the enzyme chalcone 3-hydroxylase catalyzes the hydroxylation at the C3-position of the A-ring of chalcones. This additional ... Both, chalcones and aurones are known as anthochlor pigments. Anthochlor pigments serve as UV nectar guides in some plants. ...
پلیفنل - ویکیپدیا، دانشنامهٔ آزاد
True polyphenols from the tannin and other WBSSH types are routinely biosynthesized in the natural sources from which they derive; their 'chemical' syntheses (using standard "bench" organic chemical methods) were somewhat limited until the first decade of the new millennium because these syntheses involve challenging regioselectivity and stereoselectivity issues.[11] Early work focused on the achiral synthesis of phenolic-related components of polyphenols in the late 70's,[12] and the Nelson and Meyers synthesis of the permethyled derivative of the ubiquitous diphenic acid core of ellagitannins in 1994[13] followed by stereoselective synthesis of more complex permethylated structures such as a (+)-tellimagrandin II derivative by Lipshutz and coworkers in the same year,[14] and Itoh and coworker's synthesis of a permethylated pedunculagin with particular attention to axial symmetry issues in 1996.[15] The total synthesis of a fully unmasked polyphenol, that of the ellagitannin tellimagrandin I, ...
Lophira alata
Likewise, two chalcone tetramers were isolated as inhibitors of Epstein-Barr virus (EBV)-activation induced by a tumor promoter ... Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters. Murakami A, Tanaka ...
Phloroisovalerophenone synthase
"4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates". Phytochemistry. 49 (7): 1945- ...
Juliá-Colonna epoxidation
The hydroperoxide anion and chalcone assemble in a complex with the poly-leucine catalyst before reacting to form a peroxide ... doi:10.1039/B404390C Carrea, G.; Colonna, S.; Meek, A. D.; Ottolina, G.; Roberts, S. M., "Kinetics of chalcone oxidation by ... The Juliá-Colonna epoxidation of electron-deficient olefins was originally demonstrated with chalcones, but it was soon ... the chalcone substrate is soluble in the organic phase, generally toluene or carbon tetrachloride. The alkaline hydrogen ...
Fisetin
Chalcone synthase, the first enzyme of this pathway, produces chalcone from 4-coumaroyl-CoA. All flavonoids are derived from ... this chalcone backbone (this family being the so-called chalconoids). The activity of different enzymes, including isomerases ...
Plant secondary metabolism
... and this is then combined with malonyl-CoA to produce chalcones which are backbones of Flavonoids Chalcones are aromatic ... The closure of chalcones causes the formation of the flavonoid structure. Flavonoids are also closely related to flavones which ...
chalcone (CHEBI:27618)
cis-chalcone (CHEBI:48966) is a chalcone (CHEBI:27618). trans-chalcone (CHEBI:48965) is a chalcone (CHEBI:27618). ... chalcone (CHEBI:27618) has role plant metabolite (CHEBI:76924) chalcone (CHEBI:27618) is a chalcones (CHEBI:23086) chalcone ( ... CHEBI:27618 - chalcone. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene ...
chalcones (CHEBI:23086)
phlorizin chalcone (CHEBI:80486) is a chalcones (CHEBI:23086). pinocembrin chalcone (CHEBI:80484) is a chalcones (CHEBI:23086) ... chalcones (CHEBI:23086) is a aromatic ketone (CHEBI:76224) chalcones (CHEBI:23086) is a enone (CHEBI:51689) chalcones (CHEBI: ... Pinostrobin chalcone (CHEBI:174555) is a chalcones (CHEBI:23086). Pongachalcone I (CHEBI:180260) is a chalcones (CHEBI:23086). ... chalcone (CHEBI:27618) is a chalcones (CHEBI:23086). Citrunobin (CHEBI:175512) is a chalcones (CHEBI:23086). Crassichalcone ( ...
Chalcone - Wikipedia
Chalcones have two absorption maximums at 280 nm and 340 nm. Chalcones can be prepared by an aldol condensation between ... The specific case for formation of 3,5-diphenyl-1H-pyrazole from chalcone itself can be represented as: Chalcones and their ... Chalcone complexes have also been reported. Several natural and (semi) synthetic chalcones have shown anti-cancer activity due ... "Photochemistry of chalcone and the application of chalcone-derivatives in photo-alignment layer of liquid crystal display". ...
Glycine max chalcone synthase (CHS8), mRNA - Nucleotide - NCBI
Glycine max chalcone synthase (CHS8), mRNA Glycine max chalcone synthase (CHS8), mRNA. gi,1205914835,ref,NM_001317656.2, ... Soybean chalcone isomerase: evolution of the fold, and the differential expression and localization of the gene family. [Planta ... Soybean chalcone isomerase: evolution of the fold, and the differential expression and localization of the gene family.. ...
Chalcone synthase - Wikipedia
Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of ... Cain CC, Saslowsky DE, Walker RA, Shirley BW (October 1997). "Expression of chalcone synthase and chalcone isomerase proteins ... Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. 4-coumaroyl-CoA ... Other light sensitive domains include Box I, Box II, Box III, Box IV or three copies of H-box (CCTACC). The chalcone synthase ...
Chalcone - Substance Information - ECHA
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...
Chalcone, 2',6'-dihydroxy-4'-methoxy, bis-TMS
The flavokawains: uprising medicinal chalcones
Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the ... The flavokawains: uprising medicinal chalcones Cancer Cell Int. 2013 Oct 22;13(1):102. doi: 10.1186/1475-2867-13-102. ... Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the ...
Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
2′,4-Dihydroxy-4′-methoxy chalcone (7): yellow needles, yield 86%, and m.p. 152~153°C; 1H NMR (400 MHz, DMSO-. ): δ 3.95 (3H, s ... Chalcones 28~32 were prepared by using aldol condensation of appropriate substituted benzaldehydes 23~27, 33, 34, and acetyl ... 2′-Hydroxy-3,4,4′-trimethoxy chalcone (8): yellow needles, yield 74%, and m.p. 145~147°C; 1H NMR (400 MHz, CDCl3): δ 3.95 (9H, ... To a solution of chalcones 6~8, 28~32 (0.3 mmol) in methanol (5.5 mL) was, respectively, added 16% NaOH (aq) (0.6 mL), 15% H2O2 ...
Dipole moments of selenophene analogs of the chalcones | SpringerLink
The dipole moments of 24 selenophene analogs of the chalcones have been measured and have been compared with the data ... Organic Chemistry Ketone Dipole Moment Chalcones Conformational State This is a preview of subscription content, log in to ... The dipole moments of 24 selenophene analogs of the chalcones have been measured and have been compared with the data ...
CHS - Chalcone synthase - Pinus sylvestris (Scots pine) - CHS gene & protein
... also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. ... IPR012328. Chalcone/stilbene_synth_C. IPR018088. Chalcone/stilbene_synthase_AS. IPR001099. Chalcone/stilbene_synthase_N. ... IPR012328. Chalcone/stilbene_synth_C. IPR018088. Chalcone/stilbene_synthase_AS. IPR001099. Chalcone/stilbene_synthase_N. ... The primary product of this enzyme is 4,2,4,6-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can ...
Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity
RNA-mediated RNA degradation and chalcone synthase A silencing in petunia. - PubMed - NCBI
CHI - Chalcone--flavonone isomerase - Canna generalis (Canna lily) - CHI gene & protein
Responsible for the isomerization of 4,2,4,6-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity). ... Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. ... IPR016087 Chalcone_isomerase. IPR016088 Chalcone_isomerase_3-sand. IPR016089 Chalcone_isomerase_bundle_sf. IPR036298 Chalcone_ ... IPR016087 Chalcone_isomerase. IPR016088 Chalcone_isomerase_3-sand. IPR016089 Chalcone_isomerase_bundle_sf. IPR036298 Chalcone_ ...
Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ...
... Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ... Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ... Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ...
Structural insights into a novel anticancer sulfonamide chalcone - New Journal of Chemistry (RSC Publishing)
Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. ... Structural insights into a novel anticancer sulfonamide chalcone J. M. F. Custodio, L. J. Michelini, M. R. C. de Castro, W. F. ... We show that the BSC compound has a planar conformation in its chalcone portion, which is further corroborated by the low angle ... Herein, we report the synthesis and structural elucidation of a novel sulfonamide chalcone 2,5-dichloro-N-{3-[(2E)-3-(4- ...
ChemEngineering | Free Full-Text | Synthesis of Chalcone Using LDH/Graphene Nanocatalysts of Different Compositions | HTML
... the chalcone isomers, i.e., trans-chalcone (1) and cis-chalcone (2), the Michael addition product (1,3,5-triphenylpentan-1-5- ... When toluene is used as solvent, trans-chalcone (1), cis-chalcone (2) and Michael addition product (3) were formed (Figure 6C ... LDH-rGO-20 and LDH-rGO-10 lead to the higher yields of trans-chalcone (1) and cis-chalcone (2), respectively and, most ... When methanol is used as solvent cis-chalcone (2), trans-chalcone (1) and aldol (4) are only obtained while the Michael ...
Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications
Chalcone could produce two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about -0.689 V. The differential ... differential pulse and square wave voltammetric techniques for the determination of trace-level chalcone at a glassy carbon ... Chalcone could produce two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about -0.689 V. The differential ... O. V. Yarishkin, W. R. Hyung, P. Jae-Yong, S. Y. Min, H. Seong-Geun and H. P. Ki, "Sulfonate Chalcone as New Class Voltage- ...
Chalcone | definition of chalcone by Medical dictionary
... chalcone explanation free. What is chalcone? Meaning of chalcone medical term. What does chalcone mean? ... Looking for online definition of chalcone in the Medical Dictionary? ... chalcone. Also found in: Wikipedia. chal·cone. (kalkōn), The parent compound of a series of plant pigments. All are flavonoids ... lactiflora, including phenylalanine ammonialyase gene (PAL), chalcone synthase gene (CHS), chalcone isomerase gene (CHI), F3H, ...
Molecules | Free Full-Text | Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model
Chalcone and four chalcone analogues 1a-d were evaluated using zebrafish embryos following antibody staining to visualize their ... Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on ... The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. ... The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone ...
Chalcones | definition of Chalcones by Medical dictionary
Chalcones explanation free. What is Chalcones? Meaning of Chalcones medical term. What does Chalcones mean? ... Looking for online definition of Chalcones in the Medical Dictionary? ... chalcone. (redirected from Chalcones) chal·cone. (kalkōn), The parent compound of a series of plant pigments. All are ... Chalcones , definition of Chalcones by Medical dictionary https://medical-dictionary.thefreedictionary.com/Chalcones ...
Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and...
Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. However, the ... Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids (5d-7j, 9d-11f, 12k-13m) against AChE and BChE. ... Coumarin Chalcone Cholinesterase inhibitors Structure-activity relationship Tertiary amine group Electronic supplementary ... Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. However, the ...
Effects of chalcone derivatives on players of the immune system | DDDT
Chalcone derivatives exhibit a broad spectrum of pharmacological activities, such as immunomodulation, as well as anti- ... This review highlights the effects of chalcone derivatives in different types of immune cells. Keywords: macrophages, ... Effects of chalcone derivatives on players of the immune system Jian Sian Lee, Syed Nasir Abbas Bukhari, Norsyahida Mohd Fauzi ... Effects of chalcones in T cells. In work investigating the role of chalcones in T cells, these were found to inhibit the ...
New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
TALIA, Juan Manuel; DEBATTISTA, Nora Beatriz and PAPPANO, Nora Beatriz. New antimicrobial combinations: substituted chalcones- ... Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. ... The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with ...
Frontiers | Novel Chalcone-Based Fluorescent Human Histamine H3 Receptor Ligands as Pharmacological Tools | Frontiers in...
All synthesized chalcone compounds could be taken to visualize hH3R proteins in stably transfected HEK-293 cells using confocal ... All synthesized chalcone compounds could be taken to visualize hH3R proteins in stably transfected HEK-293 cells using confocal ... Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH3R in the same concentration range ... Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH3R in the same concentration range ...
Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and...
... complexes having chalcone or flavonol ligands and Schiff base (N-phenyl-5-chlorosalicylideneimine) as co-ligand were prepared, ... Copper(II) chalcone complexes, with square-pyramidal CuO4N core, are binuclear, featuring phenolate oxygen from the Schiff base ... Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like ... "Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like ...
Douglas Laboratories Hesperidin Methyl Chalcone 60 Caps - Swanson Health Products
Trusted since 1969, we offer trusted quality and great value on Douglas Laboratories Hesperidin Methyl Chalcone 60 Caps ... Shop the best Douglas Laboratories Hesperidin Methyl Chalcone 60 Caps products at Swanson Health Products. ... Hesperidin Methyl Chalcone from Douglas Laboratories supports circulation health. This methylated form of the flavonoid ...
Solvent viscosity tuned highly selective NIR and ratiometric fluorescent sensing of Fe3+ by a symmetric chalcone analogue -...
... and ratiometric fluorescence responses for Fe3+ by a symmetric chalcone analogue (receptor 1). The key step behind NIR ... chalcone. analogue U. Diwan, A. Kumar, V. Kumar and K. K. Upadhyay, Dalton Trans., 2013, 42, 13889 DOI: 10.1039/C3DT50733E ... chalcone. analogue (receptor 1). The key step behind NIR chromogenic response was attributed to chelation of Fe3+ with receptor ...
The Dominant Inhibitory Chalcone Synthase Allele C2-Idf (Inhibitor diffuse) From Zea mays (L.) Acts via an Endogenous RNA...
Niesbach-Klösgen, U., E. Barzen, J. Berhardt, W. Rohde, Z. Schwarz-Sommer et al., 1987 Chalcone synthase genes in plants: a ... Franken, P., U. Niesbach-Klosgen, U. Weydemann, L. Marechal-Drouard, H. Saedler et al., 1991 The duplicated chalcone synthase ... AY728478 [c2 gene chalcone synthase (wild type) C2-W22], AY728476 (Zea mays L. C2-Idf allele; gene copies C2-Idf-I and C2-Idf- ... Jorgensen, R. A., P. D. Cluster, J. English, Q. Que and C. A. Napoli, 1996 Chalcone synthase cosuppression phenotypes in ...
Molecules | Free Full-Text | The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in Vitro Anti...
In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which ... Pan Y, Chen Y, Li Q, Yu X, Wang J, Zheng J. The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in ... Pan, Y.; Chen, Y.; Li, Q.; Yu, X.; Wang, J.; Zheng, J. The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone ... In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which ...
CompoundsOptimizing chalcone derivativesAbstractFlavonoidsCytotoxicityIsomeraseNaringeninGeneApoptosisEnzymeAnalogsFlavonoidAnticancerKinetics and Mechanism of OxidationMoleculesKetonePotentHesperidin methyl chalconeSynthetic chalconesInhibitoryFlavanonesAntioxidant ActivityEffects of chalconePhenylalanine ammonInhibitsAnaloguesAntimicrobial activityAntibacterial ActivityActivityCOMPOUNDAntifungalSynthase genesSulfonamide chalconeMethylGenesExtractCondensationMolecularHybridsHydrazide derivativesProteinMechanismXanthohumolAlzheimer'sFlavokawainDerivatives were synthesizedNaturally
Compounds23
- Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. (wikipedia.org)
- Type III PKSs are associated with the production of chalcones, a class of organic compounds found mainly in plants as natural defense mechanisms and as synthetic intermediates. (wikipedia.org)
- Chalcones are a class of natural compounds that widely exist in a variety of plant species. (hindawi.com)
- Despite lots of recent impressive reports on chalcones [ 8 , 9 ] and 5-deoxyflavonoids [ 10 ], the full potential of such class of compounds is yet to be realized in terms of both more new molecules as drugs and varied biological activity. (hindawi.com)
- Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. (rsc.org)
- Zavrsnik, DFT Study and Microbiology of Some Coumarin-Based Compounds Containing a Chalcone Moiety, J. (thefreedictionary.com)
- The induction of chalcone synthase and phenylalanine ammonia-lyase by salicylic acid application which results in the synthesis of certein phenolic compounds that play an important role in conferring resistance against various abiotic stresses including temperature stress (Campos et al, 2003) further supports our results. (thefreedictionary.com)
- rufogrisea Chemical class Alkaloids - Phenolic compounds Anthraquinones + Coumarins + Tannins + Xanthones + Flavonoids Aurones - Catechins--Catechin + tannins Flavonoids Chalcones - Flavonols + Flavanones + Terpenoids and steroids Saponins + Alpha, beta-unsaturated lactones + Steroid nuclei + 2-deoxy sugars + The signs (+) and (-) indicate, respectively, the presence or absence of the chemical classes in the analyzed plant material. (thefreedictionary.com)
- These species are known to produce many insecticidal compounds such as alkaloids, sesquiterpenes, chalcones , and flavonoids (Romo de Vivar et al. (thefreedictionary.com)
- Compounds with para -substituted chalcone fragments in which the substituents were choline-like had potent activity against AChE and poor activity against BChE, while ortho -substituted analogs exhibited an opposite effect. (springer.com)
- All synthesized chalcone compounds could be used to visualize hH 3 R proteins in stably transfected HEK-293 cells using confocal laser scanning fluorescence microscopy. (frontiersin.org)
- On the other hand, acylhydrazides (a class of compounds structurally related to chalcones) have been successfully investigated against T. cruzi cruzain. (scielo.br)
- Kavalactones and chalcones are two main classes of compounds identified from kava extracts ( 12 ). (aacrjournals.org)
- Among them, synthesized ionone based chalcones derivatives act as potent antiprostate cancer compounds. (ijpsonline.com)
- However, one of the compounds was instead found to stabilize tubulin to the same extent as the known anticancer drug docetaxel, thus representing the first chalcone with microtubule stabilizing activity. (dissertations.se)
- A series of novel hydroxy-pyran-chalcone hybrid compounds 4(a-b), 5(a-f), 7(a-b) & 8(a-f) has been synthesized by employing simple methods in various approaches through convergent synthetic strategies. (eurekaselect.com)
- To evaluate the hepatotoxic potential of single compounds, six kavalactones were isolated from an acetonic kava root extract and the three kava-chalcones (flavokawains) were obtained by synthesis. (uni-regensburg.de)
- Whereas the toxicity of five tested kavalactones was found to be very low (K, M, DMY) or completely absent (DHK, DHM), distinct effects on both cell viability and proliferation were observed for the kavalactone Y and the kava-chalcones, FKB being the most toxic (IC50 ~ 30 µM on HepG2 and IC50 ~ 40 µM on HuH-7) of the test compounds. (uni-regensburg.de)
- Background: Structural similarity in Chalcone and Pyrazoline brought our intention for the analysis of such compounds. (lettersindrugdesigndiscovery.com)
- Novel anthraquinone based chalcone compounds were synthesized starting from 1-acetylanthraquinone in a Claisen-Schmidt reaction and evaluated for their anticancer potential against three human cancer cell lines. (ac.rs)
- Among the screened chalcone derivatives two were selected as potential lead compounds to designpotent inhibitors for acetylcholinesterase: 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one(3k) and 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one (4k). (e-jurnal.com)
- Moreover, numerous compounds from the family of dietary chalcones appear to show activity against cancer cells, suggesting that these molecules or their derivatives may be considered as potential anticancer drugs. (biomedcentral.com)
- The cytotoxic activity of all compounds synthesized here and of two other related sulfonamide chalcones was also assessed against three cancer cell lines (SF-295, HCT-8 and MDA-MB-435). (ufg.br)
Optimizing chalcone derivatives1
- The present study forms a basis for optimizing chalcone derivatives structures to improve their second-order nonlinear optical properties and therma stability. (scirp.org)
Abstract1
- Abstract A series of six novel heterocyclic chalcone analogues 4a-f has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. (duhnnae.com)
Flavonoids5
- vsad1 is a previously identified allele of the transparent testa 4 gene ( tt4 ), which encodes chalcone synthase (CHS), a key enzyme involved in the biosynthesis of flavonoids. (springer.com)
- Anjari S.S. (2010), "Evaluation of Antioxidant Activity of Chalcones and Flavonoids" International Journal of ChemTech Research, (2), 1080-1089. (pharmatutor.org)
- Chalcone synthase (CHS) is the key enzyme in the flavonoids biosynthesis pathway, and has been proved to monitor the changes to drought stress tolerance. (preprints.org)
- trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. (medchemexpress.com)
- Chalcone synthase is a key enzyme in the biosynthesis of flavonoids, including certain phytoalexins derived from a 6′-deoxychalcone which is synthesized by cooperation of chalcone synthase with a reductase. (uni-leipzig.de)
Cytotoxicity7
- In our continued efforts to use natural products only as synthetic templates and thereby replace the original plant sources with synthetic ones and investigate structure-activity relationship, herein, we wish to report the synthesis and cytotoxicity bioassays of a series of chalcones 1 ~ 8 and 5-deoxyflabonoids 9 ~ 16 as well as their glycoside derivatives 17 ~ 22 . (hindawi.com)
- Cytotoxicity of selected novel chalcone derivatives on human breast, lung and hepatic carcinoma cell lines. (thefreedictionary.com)
- Masood, Anti-HIV cytotoxicity enzyme inhibition and molecular docking studies of quinoline based chalcones as potential non-nucleoside reverse transcriptase inhibitors (NNRT), Bioorg. (thefreedictionary.com)
- The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. (eurekaselect.com)
- trans-Chalcone exhibits a pronounced cytotoxicity activity [1] . (medchemexpress.com)
- Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. (medchemexpress.com)
- Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus. (bioseek.eu)
Isomerase8
- Soybean chalcone isomerase: evolution of the fold, and the differential expression and localization of the gene family. (nih.gov)
- Through FLIM FRET, it was shown that CHS interacts with chalcone isomerase (CHI), a consecutive step enzyme, as well as other non-consecutive step enzymes flavanone 3-hydroxylase (F3H), dihydroflavonol 4-reductase (DFR), and flavonol synthase I. Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. (wikipedia.org)
- Here, we identify two noncatalytic chalcone isomerase-fold proteins, which are critical for high-efficiency prenylchalcone production in Humulus lupulus . (pnas.org)
- Our results provide insights into their evolutionary development from the ancestral noncatalytic fatty acid-binding chalcone isomerase-fold proteins to specialized auxiliary proteins supporting flavonoid biosynthesis in plants, and open up the possibility of producing high-value plant prenylchalcones using heterologous systems. (pnas.org)
- In this study, we characterized two noncatalytic chalcone isomerase (CHI)-like proteins (designated as HlCHIL1 and HlCHIL2) using engineered yeast harboring all genes required for DMX production. (pnas.org)
- Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase. (thefreedictionary.com)
- The scientists were able to significantly increase the total flavonol content in both the peel and flesh using the onion chalcone isomerase (CHI) gene. (thefreedictionary.com)
- In this study, we establish that chalcone isomerase-like proteins (CHILs), which are encoded by genes that are ubiquitous in land plant genomes, bind to CHS to enhance THC production and decrease CTAL formation, thereby rectifying the promiscuous CHS catalysis. (elsevier.com)
Naringenin10
- Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of polyketide synthase enzymes (PKS) known as type III PKS. (wikipedia.org)
- The enzyme catalyzes the conversion of 4-coumaroyl-CoA and malonyl-CoA to naringenin chalcone. (wikipedia.org)
- 4-coumaroyl-CoA and three units of malonyl-CoA are converted into three molecules of carbon dioxide, four molecules of coenzyme A and one unit of naringenin chalcone. (wikipedia.org)
- After the generation of a thioester-linked tetraketide, a regiospecific C1,C6 Claisen condensation occurs, forming a new ring system to generate naringenin chalcone. (wikipedia.org)
- CHS is noncompetitively inhibited by flavanoid pathway products such as naringenin and chalcone naringenin. (wikipedia.org)
- The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. (uniprot.org)
- 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO 2 . (uniprot.org)
- Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity). (uniprot.org)
- Resveratrol and chalcone synthases utilize the same substrates (4-coumaroyl-CoA and 3 molecules of malonyl-CoA ) and catalyze the same condensing type of enzyme reaction (resulting in sequential addition of acetate units via malonyl-CoA ), but the products differ in the newly formed ring systems (resveratrol and naringenin chalcone). (uni-leipzig.de)
- Biosynthesis of naringenin chalcone in plants and citruses. (biomedcentral.com)
Gene10
- Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. (thefreedictionary.com)
- C2-Idf is a stable dominant mutation of the chalcone synthase gene, c2 , which encodes the first dedicated enzyme in this biosynthetic pathway of maize. (genetics.org)
- To assess the possible role of some of the genes potentially involved in cell wall lipid synthesis, we disrupted a mas -like gene, msl7 , and a chalcone synthase-like gene, pks10 , with phage-mediated delivery of the disruption construct, in which the target gene was disrupted by replacement of an internal segment with the hygromycin resistance gene ( hyg ). (asm.org)
- UV-B, UV-A, and blue light signal transduction pathways interact synergistically to regulate chalcone synthase gene expression in Arabidopsis. (plantcell.org)
- Here, we provide evidence that several distinct "inductive" and "synergistic" UV/blue phototransduction pathways regulate chalcone synthase (CHS) gene transcription and transcript accumulation in Arabidopsis leaf tissue. (plantcell.org)
- Weisshaar B, Block A, Armstrong GA, Herrmann A, Schulze-Lefert P, Hahlbrock K. Regulatory elements required for light-mediated expression of the Petroselinum crispum chalcone synthase gene. (uni-bielefeld.de)
- Regulatory elements required for light-mediated expression of the Petroselinum crispum chalcone synthase gene", Proceedings of the Society for Experimental Biology and Medicine , vol. 45, 1991, pp. 191-210. (uni-bielefeld.de)
- Ashitaba Chalcones help promote the expression of the adiponectin gene and 3t3-l1 adiponectin adipogenesis in order to prevent metabolic syndrome. (dyna-nutrition.com)
- Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. (medchemexpress.com)
- The effect of gamma irradiation, either as a single elicitor or coupled with salinity, on chalcone synthase (CHS) gene expression and silybin A + B yield was also evaluated. (must.edu.eg)
Apoptosis2
- 3) Chalcones possess an interesting pharmacological profile for the treatment of hepatic fibrosis, as they comprise several favorable biological activities such as anti-inflammatory, anti-oxidant, antiviral, and apoptosis-inducing effects. (uni-regensburg.de)
- trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. (medchemexpress.com)
Enzyme8
- Chalcones are the promising candidates in inhibiting various cardiovascular, hematological and anti-obesity targets like angiotensin-converting enzyme (ACE), cholesteryl ester transfer protein (CETP), diacylglycerol acyltransferase (DGAT), acyl-coenzyme A: cholesterol acyltransferase (ACAT), pancreatic lipase (PL), lipoprotein lipase (LPL), calcium (Ca2+)/potassium (K+) channel, thromboxane (TXA2 and TXB2), etc. (wikipedia.org)
- One of the structural genes, colorless2 ( c2 ), encodes chalcone synthase, the enzyme responsible for the first dedicated step in the pathway. (genetics.org)
- At the enzyme level, the effect on aleurone pigmentation is due to a lack of chalcone synthase enzyme activity ( D ooner 1983 ). (genetics.org)
- In the present work, we describe the synthesis and inhibitory effects of a series of thirty-three chalcone and seven hydrazide derivatives against the enzyme cruzain from T. cruzi . (scielo.br)
- Amjad, M.W.B. (2013), "Synthesis and evaluation of chalcone analogues based pyrimidines as angiotensinconverting enzyme inhibitors", Pakistan Journal of Biological Science, 16(21), 1368-1372. (pharmatutor.org)
- Aslan, G.(2017), "Design of potent fluoro-substituted chalcones as antimicrobial agents", Journal Of Enzyme Inhibition And Medicinal Chemistry, 32(1), 490-495. (pharmatutor.org)
- cDNA clones encoding chalcone synthase (CHS) (EC 2.3.1.74), a key enzyme involved in flavonoid and anthocyanin biosynthesis were isolated from a cDNA library constructed from flowers of the orchid, Bromheadia finlaysoniana (Lindl. (nus.edu.sg)
- Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic pathway and catalyzes the production of 2′,4,4′,6′-tetrahydroxychalcone (THC). (elsevier.com)
Analogs5
- The dipole moments of 24 selenophene analogs of the chalcones have been measured and have been compared with the data calculated by a vectorial additive scheme and also with their chemical structures. (springer.com)
- In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free radical activity, and screened their effects on scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro . (mdpi.com)
- Pan Y, Chen Y, Li Q, Yu X, Wang J, Zheng J. The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in Vitro Anti-Free Radicals Pharmacological Activity and in Vivo Anti-Oxidation Activity in a Free Radical-Injury Alzheimer's Model. (mdpi.com)
- Chalcones and their heterocyclic analogs appreciate a scope of organic exercises, for example, antimicrobial, cancer prevention agent, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and calming exercises which makes these mixes as an extraordinary fascination for examination. (alliedacademies.org)
- A series of substituted chalcone oxides (1,3-diphenyl-2-oxiranyl propanones) and structural analogs was synthesized to investigate the mechanism by which they inhibit soluble epoxide hydrolases (sEH). (elsevier.com)
Flavonoid3
- Chalcones are regular item has a place with Flavonoid family. (alliedacademies.org)
- Chalcones are a valuable molecule of medicinal importance due to presence of reactive ketoethylenic group -CO-CH=CH-, belonging to the flavonoid family. (pharmatutor.org)
- Chalcone synthase (CHS) catalyzes the committed enzymatic step in flavonoid biosynthesis. (uni-bielefeld.de)
Anticancer5
- Synthesis and Biological Evaluation of Simple Methoxylated Chalcones as Anticancer, Anti-inflammatory and Antioxidant Agents. (thefreedictionary.com)
- Chalcone derivatives exhibit a broad spectrum of pharmacological activities, such as immunomodulation, as well as anti-inflammatory, anticancer, antiviral, and antimicrobial properties. (dovepress.com)
- This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. (dissertations.se)
- This review is focused about different methods of synthesis and versatile biological activity of chalcones including antimicrobial, anticancer, antioxidant, antimalarial, antituberculosis etc. (pharmatutor.org)
- trans-Chalcone has antifungal and anticancer activity. (medchemexpress.com)
Kinetics and Mechanism of Oxidation2
- J. A. Kumar and S. Sondu, "Kinetics and Mechanism of Oxidation of Chalcones by Ti-Ichloroisocyanuric Acid [TCICA] in HOAc-HClO4 Medium," Indian Journal of Chemistry, Vol. 46A, 2007, pp. 1792-1795. (scirp.org)
- The kinetics and mechanism of oxidation of chalcone and some substituted chalcones by trichloroisocyanuric acid (TCICA) has been investigated at 313 K in HOAc-HClO₄ medium. (niscair.res.in)
Molecules7
- Chalcone molecules deserve the credit of being potential anti-diabetic candidates that act by modulating the therapeutic targets Peroxisome proliferator-activated receptor gamma (PPAR-Γ), Dipeptidyl peptidase-4 (DPP-4), α-glucosidase, Protein-tyrosine Phosphatase 1B (PTP1B), aldose reductase, and tissue sensitivity. (wikipedia.org)
- Here, by functional and biological analysis of the most representative molecules of an in house library of natural products, we have designed and synthetized the chalcone-derivative 8 possessing Notch inhibitory activity at low micro molar concentration in T-ALL cell lines. (sigmaaldrich.com)
- Herein, we report the synthesis, structures, and characterization of a series of five chalcone derivatives, obtained by carefully modifying the structure with various para and meta substitutents, expecting new molecules with high second-order optical nonlinearities. (scirp.org)
- Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. (eurekaselect.com)
- Chern, C.Y. (2013), "Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model", Molecules, (18), 2052-2060. (pharmatutor.org)
- Tran, T.D. (2016), "Synthesis and Selective Cytotoxic Activities on Rhabdomyosarcoma and Noncancerous Cells of Some Heterocyclic Chalcones", Molecules, (21), 1-10. (pharmatutor.org)
- Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. (biomedcentral.com)
Ketone1
- Chalcone is a fragrant ketone that frames a focal center for an assortment of significant organic mixes, which are altogether known as chalcones. (alliedacademies.org)
Potent3
- Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. (springer.com)
- It was found that methoxy and hydroyl substituted chalcone semicarbazones were potent free radical scavenger and unsubstituted compound showed very less activity. (tsijournals.com)
- trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. (medchemexpress.com)
Hesperidin methyl chalcone3
- Other key ingredients include hesperidin methyl chalcone to promote stronger blood vessel walls, and dextra sulfate to help reduce the appearance of swelling. (thefreedictionary.com)
- Hesperidin Methyl Chalcone from Douglas Laboratories supports circulation health. (swansonvitamins.com)
- Each serving delivers 500 mg of hesperidin methyl chalcone. (swansonvitamins.com)
Synthetic chalcones1
- The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. (mdpi.com)
Inhibitory2
- The nature and position of the chalcone substituents had major effects on inhibitory activity as well as selectivity for AChE over BChE. (springer.com)
- Hence, the inhibitory activity of structurally related prenylated and non-prenylated chalcones on activated human hepatic stellate cells was investigated. (uni-regensburg.de)
Flavanones4
- Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. (uniprot.org)
- 2008a) isolated five flavanones and three chalcones from C. (thefreedictionary.com)
- Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, antiangiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. (eurekaselect.com)
- HPLC of flavanones and chalcones in different species and clones of Salix. (semanticscholar.org)
Antioxidant Activity1
- In the present study a series of chalcone semicarbazones was synthesized and evaluated for antioxidant activity by DPPH free radical scavenging assay. (tsijournals.com)
Effects of chalcone1
- This review highlights the effects of chalcone derivatives in different types of immune cells. (dovepress.com)
Phenylalanine ammon1
- Anthocyanins, which accumulate in leaves and stems in response to low temperature and changes in light intensity, are synthesized through the phenylpropanoid pathway that is controlled by key enzymes that include phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS). (plantphysiol.org)
Inhibits2
- Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. (sigmaaldrich.com)
- trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM [2] . (medchemexpress.com)
Analogues4
- Chalcone and four chalcone analogues 1a - d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. (mdpi.com)
- Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos. (mdpi.com)
- Chen, Y.-H. Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model. (mdpi.com)
- Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential - Descarga este documento en PDF. (duhnnae.com)
Antimicrobial activity1
- Next, chalcone derivatives were synthesized and assayed for their antimicrobial activity against several bacterial strains in combination with penicillin antibiotics. (thefreedictionary.com)
Antibacterial Activity4
- Several chalcones showed in vitro antibacterial activity against Gram-bacterial. (deepdyve.com)
- Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides. (currentorganicsynthesis.com)
- Materials and Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated. (currentorganicsynthesis.com)
- In the current study, an efficient synthesis of new triazole-linked chalcone 3 a-g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. (elsevier.com)
Activity17
- Transgenic Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone synthase activity and purple flower pigment through posttranscriptional chsA RNA degradation. (nih.gov)
- We show that CHIL2 is part of an active DMX biosynthetic metabolon in hop glandular trichomes that encompasses a chalcone synthase (CHS) and a membrane-bound prenyltransferase, and that type IV CHI-fold proteins of representative land plants contain conserved function to bind with CHS and enhance its activity. (pnas.org)
- Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer's disease. (springer.com)
- Kahrović E, Zahirović A, Višnjevac A, Osmanković I, Turkušić E, Kurtagić H. Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like Activity. (srce.hr)
- Kinetic measurements revealed that the binuclear (chalcone-containing) complexes have enhanced catalytic activity as compared to the mononuclear Cu(II) flavonol complexes. (srce.hr)
- Structure-activity relationships were afforded for the chalcone scaffold. (sigmaaldrich.com)
- We here highlight the unique relationship between pharmacokinetics and anti-asthmatic activity of chalcone 4, a CXCL12 neutraligand. (ersjournals.com)
- Molecular modeling methods performed on forty-three ionone based chalcones derivatives as anti-prostate cancer activity. (ijpsonline.com)
- Present study deals with comparative molecular field analysis, comparative similarity indices analysis and hologram quantitative structure activity relationship and molecular docking studies of the ionone-based chalcones and their derivatives, obtained from literature. (ijpsonline.com)
- These reactive α,β-unsatutated keto function in chalcones are responsible for their biological activity. (pharmatutor.org)
- In order to gain further insights into the structural requirements for anti-tuberculosis activity by chalcone derivatives of 1,3-diphenylprop-2-ene-1-one, quantitative structure activity relationship (QSAR) was performed using genetic function approximation (GFA). (oalib.com)
- The highest scavenger activity observed in compound 23 is probably due to the presence of hydroxyl group in the acetophenic moiety and methoxy group in aldehydic moiety of the chalcone. (tsijournals.com)
- Recent insights into the mechanism of epoxide hydrolase activity are combined with these experimental results to support a proposed mechanism of sEH inhibition by chalcone oxides. (elsevier.com)
- Cytotoxic Activity of Chalcones Isolated from Lonchocarpus Sericeus (Pocr. (semanticscholar.org)
- Three chalcone derivatives with amine groups (4a-c) were synthesized and evaluated for their antimalarial activity.Three aminoalkylated chalcone derivatives (4a-c) have been prepared through Claisen-Schmidt condensation reactionfrom vanillin and chloroacetophenone, followed by the Mannich reaction to add amine group. (who.int)
- The addition of morpholine (4a), piperidine (4b), and diethylamine (4c) as amine groups significantlycould improve the antimalarial activity with IC50 of 0.62, 0.54, and 1.12 µM, respectively (strong activity), comparedwith the chalcone without amine group (3) with IC50 of 25.84 µM (moderate activity). (who.int)
- Some of the chalcones have exhibited moderate activity. (bvsalud.org)
COMPOUND5
- Methyl on the aromatic ring of chalcones was brominated by NBS, and then the resulting mixture was reacted with imidazole to get the target compound. (deepdyve.com)
- Antidepressant-like Effect of a Chalcone Compound, DHIPC and Its Possible Mechanism', Iranian Journal of Pharmaceutical Research , 17(1), pp. 193-201. (ac.ir)
- DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalcone compound. (ac.ir)
- RESULTS: Several related chalcones, acyl hydrazides, and amides killed cultured bloodstream forms of T. b. brucei, with the most effective compound reducing parasite numbers by 50% relative to control populations at a concentration of 240 nM. (ox.ac.uk)
- In the compound came from N-(4-acetylphenyl) benzenesulfonamide and benzaldehyde, there is a rotation of ca. 180° on the bond axis bridging the sulfonamide and chalcone motifs of one conformer if the two others are taken as references. (ufg.br)
Antifungal2
- The chalcone derivatives were evaluated for in vitro antibacterial, antifungal, antioxidant activities. (ajol.info)
- Antifungal and antibacterial chalcones from Myrica serrata. (semanticscholar.org)
Synthase genes1
- Silybin content and overexpression of chalcone synthase genes in Silybum marianum L. plants under abiotic elicitation. (must.edu.eg)
Sulfonamide chalcone2
- Herein, we report the synthesis and structural elucidation of a novel sulfonamide chalcone 2,5-dichloro- N -{3-[(2 E )-3-(4-nitrophenyl)prop-2-enoyl]phenyl}benzenesulfonamide (BSC) by Single Crystal X-ray Diffraction and spectroscopy analysis (Infrared, NMR and Mass Spectroscopy). (rsc.org)
- Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. (ufg.br)
Methyl5
- A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. (ebi.ac.uk)
- Five 1,3-diarylprop-2-en-1-ones 3a-e are synthesized by Claisen-Schmidt condensation of aryl methyl ketones and 4-chlorobenzaldehyde to give pyrazolines 5a-e by cyclization with phenylhydrazine in gl. (niscair.res.in)
- 4-hydroxy-3-acetylcoumarin and 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one have been used as starting materials and were condensed with indole aldehyde, pyrrole aldehydes independently to give the corresponding chalcones. (eurekaselect.com)
- 3-Acetyl-4-hydroxy-2H-chromen-2-one, 3-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one, indoles, pyrroles, chalcones, alkylation. (eurekaselect.com)
- The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. (bioseek.eu)
Genes1
- Genome-wide analysis of the chalcone synthase superfamily genes of Physcomitrella patens Koduri, P. (deepdyve.com)
Extract2
- Flavokawain A (FKA), a major chalcone from kava extract, has been reported to have antitumor effects on multiple cancer cell lines. (aacrjournals.org)
- AshiGuard is a whole food supplement that contains standardized ashitaba chalcone extract. (dyna-nutrition.com)
Condensation7
- Chalcones can be prepared by an aldol condensation between benzaldehyde and acetophenone in the presence of sodium hydroxide as a catalyst. (wikipedia.org)
- In a study investigating green syntheses, chalcones were synthesized from the same starting materials in high-temperature water (200 to 350 °C). Substituted chalcones were also synthesised by piperidine-mediated condensation to avoid side reactions such as multiple condensations, polymerizations, and rearrangements. (wikipedia.org)
- Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. (hindawi.com)
- Chalcones 28 ~ 32 were prepared by using aldol condensation of appropriate substituted benzaldehydes 23 ~ 27 , 33 , 34 , and acetyl phenols in KOH/EtOH and deprotection reaction. (hindawi.com)
- A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. (scirp.org)
- The five derivatives of chalcone substituted with donor-acceptor substituents ( Table 1 ) were prepared by Claisen-Schmidt condensation reaction [8] (Scheme 1). (scirp.org)
- Twelve new chalcones were synthesized by claisen-schmidid condensation and studies for their toxicity to fish. (bvsalud.org)
Molecular3
- To date, no report on molecular modeling has been established on ionone based chalcones for anti-prostate cancer. (ijpsonline.com)
- Molecular docking was used in order to theoretically investigate the interactions of the chalcones with ␣-tubulin mainly focusing on binding modes, potential interactions and specific binding sites. (dissertations.se)
- The chalcone molecular backbones are featured by different levels of planarity in their conformers. (ufg.br)
Hybrids1
- Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids ( 5d - 7j , 9d - 11f , 12k - 13m ) against AChE and BChE. (springer.com)
Hydrazide derivatives1
- MATERIALS AND METHODS: Chalcone and acyl hydrazide derivatives are known to retard the growth of Plasmodium falciparum in vitro and inhibit the malarial cysteine proteinase, falcipain. (ox.ac.uk)
Protein1
- See the reference protein sequence for chalcone synthase (NP_001304585.2). (nih.gov)
Mechanism1
- A suitable mechanism involving the chalcone molecule and the reactive species of TCICA in the rate determining step has also been proposed. (niscair.res.in)
Xanthohumol4
- Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. (spandidos-publications.com)
- Prenylated chalcone xanthohumol assoc. (ugent.be)
- Wyns C, Van Steendam K, Vanhoecke B, Deforce D, Bracke M, Heyerick A. Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal antibody. (ugent.be)
- The minor hop ( Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. (bioseek.eu)
Alzheimer's1
- One of well-established biological activities for chalcone derivatives is as acetylcholinesterase inhibitors, which can be developed for the therapy of Alzheimer's disease. (e-jurnal.com)
Flavokawain4
- The chalcones are flavokawain A, B, and C that constitute up to 0.46%, 0.015%, and 0.012% of kava extracts, respectively ( 12 ). (aacrjournals.org)
- Flavokawain A (FKA) is the predominant chalcone identified from the kava plant. (aacrjournals.org)
- We have shown that flavokawain B (FKB), a kava chalcone, is about 4- to 12-fold more effective in reducing the cell viabilities of androgen receptor (AR)-negative, HRPC cell lines DU145 and PC-3 than AR-positive, hormone-sensitive prostate cancer cell lines LAPC4 and LNCaP, with minimal effect on normal prostatic epithelial and stromal cells. (hawaii-agriculture.com)
- Aim: To examine the effects of flavokawain B (FKB), a novel kava chalcone, on the growth of uterine leiomyosarcoma (LMS) cells and investigated its utility in the treatment of uterine LMS. (elsevier.com)
Derivatives were synthesized2
- Results: Chalcones and their pyrazoline derivatives were synthesized and characterised by 1HNMR, 13C-NMR, Mass spectrometry and FTIR. (lettersindrugdesigndiscovery.com)
- Conclusion: Chalcone and their pyrazoline derivatives were synthesized and screened for their anti-Alzheimer and antioxidant potential. (lettersindrugdesigndiscovery.com)
Naturally1
- Although chalcones occur naturally, they could be available in larger amounts through an efficient and simple synthesis. (biomedcentral.com)