Chalcones
Acyltransferases
Intramolecular Lyases
Kava
Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots.
Phenylalanine Ammonia-Lyase
Anthocyanins
Humulus
Zingiberaceae
Plants
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
Pterocarpans
Tetrathionic Acid
Phloroglucinol
Elaeagnaceae
Plant Proteins
Plants, Medicinal
Soybeans
Mallotus Plant
Rosales
Trans-Cinnamate 4-Monooxygenase
Fabaceae
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Ammonia-Lyases
Gene Expression Regulation, Plant
Alpinia
Apiaceae
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
Viola
Helichrysum
Isomerases
Coumaric Acids
Agaricales
Asteraceae
A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.
Plant Extracts
Molecular Structure
Gefarnate
Quercetin
Arabidopsis
Base Sequence
Plants, Genetically Modified
Amino Acid Sequence
Alcohol Oxidoreductases
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Cloning, Molecular
Inhibitory Concentration 50
RNA, Plant
Seeds
Gene Expression Regulation, Enzymologic
Lycopersicon esculentum
Structure-Activity Relationship
Biosynthetic Pathways
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Isoflavones
Plant Roots
Enzyme Induction
Monophenol Monooxygenase
Melanins
Catalysis
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Immunochemistry
Fungi
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Genetic Engineering
Substrate Specificity
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Sequence Homology, Amino Acid
Tobacco
Chromatography, High Pressure Liquid
Drug Screening Assays, Antitumor
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Models, Molecular
Models, Chemical
Antineoplastic Agents, Phytogenic
Promoter Regions, Genetic
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Mutagenesis, Site-Directed
Cell Survival
Evolution, Molecular
Sequence Homology, Nucleic Acid
Sequence Analysis, DNA
Plant Leaves
Binding Sites
DNA, Complementary
Arabidopsis Proteins
Dose-Response Relationship, Drug
Magnetic Resonance Spectroscopy
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Phenotype
Mutation
Isoenzymes
Transcription, Genetic
Cells, Cultured
Enzyme Inhibitors
Blotting, Western
Crystallography, X-Ray
Chromatography, Gel
Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (1/163)
2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs. (+info)Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (2/163)
The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions. (+info)Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages. (3/163)
In a previous work, we tested a series of chalcone derivatives as possible anti-inflammatory compounds. We now investigate the effects of three of those compounds, CHI, CH8 and CH12, on nitric oxide and prostanoid generation in mouse peritoneal macrophages stimulated with lipopolysaccharide and in the mouse air pouch injected with zymosan, where they showed a dose-dependent inhibition with inhibitory concentration 50% values in the microM range. This effect was not the consequence of a direct inhibitory action on enzyme activities. Our results demonstrated that chalcone derivatives inhibited de novo inducible nitric oxide synthase and cyclooxygenase-2 synthesis, being a novel therapeutic approach for inflammatory diseases. (+info)The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. (4/163)
Our previous studies have shown that licochalcone A, an oxygenated chalcone, has antileishmanial and antimalarial activities, and alters the ultrastructure and function of the mitochondria of Leishmania spp. parasites. The present study was designed to investigate the antileishmanial activity and the mechanism of action of a group of new oxygenated chalcones. The tested oxygenated chalcones inhibited the in-vitro growth of Leishmania major promastigotes and Leishmania donovani amastigotes. Treatment of hamsters infected with L. donovani with intraperitoneal administration of two oxygenated chalcones resulted in a significant reduction of parasite load in the liver and the spleen compared with untreated control animals. The oxygenated chalcones also inhibited the respiration of the parasite and the activity of mitochondrial dehydrogenases. Electron microscopic studies illustrated that they altered the ultrastructure of the mitochondria of L. major promastigote. The data clearly indicate that this group of oxygenated chalcones has a strong antileishmanial activity and might be developed into a new antileishmanial drug. The antileishmanial activity of oxygenated chalcones might be the result of interference with function of the parasite mitochondria. (+info)Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. (5/163)
Cytochrome P-450-derived epoxyeicosatrienoic acids (EETs) are avidly incorporated into and released from endothelial phospholipids, a process that results in potentiation of endothelium-dependent relaxation. EETs are also rapidly converted by epoxide hydrolases to dihydroxyeicosatrienoic acid (DHETs), which are incorporated into phospholipids to a lesser extent than EETs. We hypothesized that epoxide hydrolases functionally regulate EET incorporation into endothelial phospholipids. Porcine coronary artery endothelial cells were treated with an epoxide hydrolase inhibitor, 4-phenylchalcone oxide (4-PCO, 20 micromol/l), before being incubated with (3)H-labeled 14,15-EET (14,15-[(3)H]EET). 4-PCO blocked conversion of 14,15-[(3)H]EET to 14,15-[(3)H]DHET and doubled the amount of radiolabeled products incorporated into cell lipids, with >80% contained in phospholipids. Moreover, pretreatment with 4-PCO before incubation with 14,15-[(3)H]EET enhanced A-23187-induced release of radiolabeled products into the medium. In contrast, 4-PCO did not alter uptake, distribution, or release of [(3)H]arachidonic acid. In porcine coronary arteries, 4-PCO augmented 14,15-EET-induced potentiation of endothelium-dependent relaxation to bradykinin. These data suggest that epoxide hydrolases may play a role in regulating EET incorporation into phospholipids, thereby modulating endothelial function in the coronary vasculature. (+info)2'-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha- and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells. (6/163)
Inhibition of expression of cell adhesion molecules (CAM), including intercellular CAM-1 (ICAM-1), vascular CAM-1 (VCAM-1), and E-selectin, has been shown to be important in controlling various inflammatory diseases. The cell adhesion proteins are induced by various inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1, and bacterial lipopolysaccharide. The induction process primarily takes place at the level of transcription, where nuclear factor-kappaB (NF-kappaB) plays a major role. We demonstrate here that 2'-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner. The inhibition by 2'-hydroxychalcone is reversible. 2'-hydroxychalcone inhibits the induction of steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin by tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction, and therefore it may interfere with the transcription of their genes. Because NF-kappaB is a major transcription factor involved in CAM expression, we studied its status in the 2'-hydroxychalcone treated cells. We demonstrate that 2'-hydroxychalcone inhibits the activation of NF-kappaB. These results have implications for using NF-kappaB inhibitors for the treatment of various inflammatory diseases. (+info)Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L. (7/163)
The flavonoid constituents in fresh florets of the three distinctive cultivars of Carthamus tinctorius L. were purified and identified to investigate flavonoid biosynthesis in the petals. From the orange flower of cv. Kenba (K.), four new compounds, anhydrosafflor yellow B (1), two kaempferols, 9 and 13, and a quercetin, 17, were isolated, as well as the twelve known compounds, and their structures were determined by spectral data, chemical reactions, and molecular mechanics calculations. From the yellow flower of cv. Ogon-hanagasa (O.), two flavonols and two quinochalcones, and from the white flower of cv. Shiro-bana (S.), three flavonois were isolated. These compounds were the same as those contained in cv. K. To compare the flavonoid constituents among the three cultivars, crude extracts were analyzed by a LC/PDA/MS system. In cv. K., six quinochalcones and eleven flavonols were identified. In cv. O., three quinochalcones and nine flavonols were identified, but the red pigment, carthamin (4), and its precursor, precarthamin (3), were not detected. In cv. S., four flavonols without a 6-hydroxyl group were identified. On the basis of a comparative study on the constituents among these three cultivars, a possible biosynthetic pathway to form quinochalcones via the intermediate, pentahydroxychalcone (19), is proposed. (+info)Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions. (8/163)
Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, obtained by alkaline hydrogenation of neohesperidin. In this investigation a supposed taste enhancing effect of this substance was tested. A three-step procedure was used. In the first experiment, using a pool of 31 subjects, NHDC and sucrose detection thresholds were measured. In the second experiment, psychophysical functions for both tastants were determined. Then, 15 participants closest to the group threshold who, in addition, had produced monotonic psychophysical taste functions were selected to participate in the next two experiments. In the third experiment, taste enhancement was tested. Three psychophysical sucrose functions were constructed, one with a near-threshold amount of NHDC added to each of seven sucrose concentrations, one with a near-threshold amount of sucrose added (control 1) and one without any addition (control 2). No difference was found between the NHDC-enriched sucrose function and the sucrose-enriched sucrose function. Finally, in experiment 4, differential threshold functions were constructed with either NHDC or sucrose added. Neither the overall shape of the functions nor a comparison of the points of subjective equality showed enhancement. It was concluded that weak NHDC does not enhance the taste of aqueous sucrose solutions. (+info)
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Targets
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Second Harmonic Generation in Some Donor-Acceptor Substituted Chalcone Derivatives
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Hiding and unveiling trans-chalcone in a constrained derivative of 4′,7-dihydroxyflavylium in water: a versatile photochromic...
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Chalcone
Chalcones have two absorption maxima at 280 nm and 340 nm. Chalcone is usually prepared by an aldol condensation between ... Some 2′-amino chalcones have been studied as potential antitumor agents. Chalcones are of interest in medicinal chemistry and ... Chalcones and chalconoids are synthesized in plants as secondary metabolites. The enzyme chalcone synthase, a type III ... "Photochemistry of chalcone and the application of chalcone-derivatives in photo-alignment layer of liquid crystal display". ...
Chalcone synthase
... or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of ... Cain CC, Saslowsky DE, Walker RA, Shirley BW (October 1997). "Expression of chalcone synthase and chalcone isomerase proteins ... Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. 4-coumaroyl-CoA ... Other light sensitive domains include Box I, Box II, Box III, Box IV or three copies of H-box (CCTACC). The chalcone synthase ...
Chalcone (skipper)
Chalcone is a genus of skippers in the family Hesperiidae. Natural History Museum Lepidoptera genus database Wikispecies has ... Chalcone (skipper), Hesperiidae genera, Taxa named by William Harry Evans, All stub articles, Hesperiinae stubs). ... information related to Chalcone. v t e (Articles with short description, Short description is different from Wikidata, Articles ...
Naringenin chalcone
... is a common chalconoid (or chalcone, not to be confused with the compound chalcone). It is synthesized from ... this process is catalyzed by chalcone isomerase. PubChem. "Naringenin chalcone". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-08-27 ... Naringenin chalcone can spontaneously cyclize to naringenin (a flavanone). In plant cells, ... 4-coumaroyl-CoA and malonyl-CoA by chalcone synthase (CHS), a key enzyme in the phenylpropanoid pathway. ...
Chalcone isomerase
In enzymology, a chalcone isomerase (EC 5.5.1.6) is an enzyme that catalyzes the chemical reaction a chalcone ⇌ {\displaystyle ... Chalcone isomerase has a core 2-layer alpha/beta structure consisting of beta(3)-alpha(2)-beta-alpha(2)-beta(3). Jez JM, Bowman ... The systematic name of this enzyme class is flavanone lyase (decyclizing). This enzyme is also called chalcone-flavanone ... Moustafa E, Wong E (1967). "Purification and properties of chalcone-flavanone isomerase from soya bean seed". Phytochemistry. 6 ...
Chalcone 4'-O-glucosyltransferase
... (EC 2.4.1.286, 4'CGT) is an enzyme with systematic name UDP-alpha-D-glucose:2',4,4',6'- ... Chalcone+4'-O-glucosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC ...
Cyanidin
"Chalcone and Stilbene Biosynthesis". Queen Mary University of London. Archived from the original on 18 October 2015. Dewick, P ... The compound reacts with naringenin-chalcone synthase and three malonyl CoA molecules to add six carbon atoms and three more ...
Chalconoid
Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. In aurones, the ... Chalcone synthase is an enzyme responsible for the production of chalconoids in plants. Chalcone isomerase is responsible for ... Chalcones are also natural aromatase inhibitors. Chalcones are aromatic ketones with two phenyl rings that are also ... "Chalcones". Reference.MD. Archived from the original on 2020-09-25. Retrieved 2011-04-30. (Chalconoids). ...
Hesperidin
The corresponding chalcone undergoes an isomerization by chalcone isomerase to afford (2S)-naringenin, which is oxidized to (2S ... E)-4-coumaroyl-CoA is then subjected to the type III polyketide synthase naringenin chalcone synthase, undergoing successive ... Jez JM, Noel JP (January 2002). "Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product ... "Low Temperature Induces the Accumulation of Phenylalanine Ammonia-Lyase and Chalcone Synthase mRNAs of Arabidopsis thaliana in ...
Butein
... is a chalcone of the chalconoids. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua), Dahlia, ...
Bioisostere
Another example is seen in a series of anti-bacterial chalcones. By modifying certain substituents, the pharmacological ... Comprehensive Pharmacy Review, 6th edition, Leon Shargel, Alan H. Mutnick, p.264 Gomes, Marcelo N. (2017). "Chalcone ... activity of the chalcone and its toxicity are also modified. Non-classical bioisosteres may differ in a multitude of ways from ...
Sophoradin
Synthesis of Isoprenyl Chalcone "Sophoradin" Isolated from Sophora subprostrata. Kazuaki Kyogoku, Katsuo Hatayama, Sadakazu ...
Pisatin
Kimura, Y.; Aoki, T.; Ayabe, S. (2001). "Chalcone isomerase isozymes with different substrate specificities towards 6′-hydroxy ... "An overexpression of chalcone reductase of Pueraria montana var. lobata alters biosynthesis of anthocyanin and 5′- ...
Curcumin synthase
Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP (2001). "Structure and mechanism of chalcone synthase- ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Natural Product ...
Ketoacyl synthase
Chalcone synthase (E.C. 2.3.1.74), also known as naringenin-chalcone synthase, is responsible for the reaction: 3 malonyl-CoA ... Both chalcone synthases and stilbene synthases will catalyze the same acyl transfer, decarboxylation, and condensation steps as ... These enzymes are normally classified as either chalcone synthases, stilbene synthases, or type III PKSs. Overall, there are 10 ... "BRENDA - Information on EC 2.3.1.74 - naringenin-chalcone synthase". www.brenda-enzymes.org. Retrieved 2016-05-04. (Enzymes). ...
Quercetin
Tetrahydroxychalcone is then converted into naringenin using chalcone isomerase. Naringenin is converted into eriodictyol using ...
Dactylorhiza
doi:10.1111/j.1095-8339.2011.01198.x. Inda, Luis A.; Pimentel, Manuel & Chase, Mark W. (2010). "Chalcone synthase variation and ...
Apigenin
Chalcone isomerase (CHI) then isomerizes the product to close the pyrone ring to make naringenin. Finally, a flavanone synthase ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Natural Product ... Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive ... condensations of three equivalents of malonyl CoA followed by aromatization to convert p-coumaroyl-CoA to chalcone. ...
Isoliquiritigenin 2'-O-methyltransferase
Other names in common use include chalcone OMT, and CHMT. Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification ...
Ingrid del Carmen Montes González
"Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium saltderivatives" Inorg. Chim. Acta; 2017 ... "Electrochemical and Spectroscopical Characterization of Ferrocenyl Chalcones" Journal of The Electrochemical Society, 2010, 157 ... "Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium salt derivatives". Inorganica Chimica Acta ... "Electrochemical and Spectroscopical Characterization of Ferrocenyl Chalcones". Journal of the Electrochemical Society. 157 (8 ...
Trochodendraceae
Epicuticular waxes are basically composed of nonacosan-10-ol.[citation needed] Tetracentron contains chalcones or ...
Chemogenetics
... as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on ... Receptor activated solely by a synthetic ligand Forkmann G, Dangelmayr B (June 1980). "Genetic control of chalcone isomerase ...
Flavones
... naringenin chalcone is shown), which is subsequently isomerized by chalcone isomerase resulting in a flavanone (naringenin is ... Coenzyme A is attached to the carboxylate facilitated by 4-Coumarate-CoA ligase, forming (Coumaroyl-CoA). A chalcone synthase ... Ferrer JL, Jez JM (1999). "Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis". Nat. ... Jez JM, Bowman ME (2000). "Structure and mechanism of the evolutionarily unique plany enzyme chalcone isomerase". Nat. Struct. ...
Dihydrochalcone
It is the reduced derivative of chalcone (C6H5C(O)(CH)2C6H5). It is white solid that is soluble in many organic solvents. ... Tomás-Barberán, Francisco A.; Clifford, Michael N. (2000). "Flavanones, Chalcones and Dihydrochalcones - Nature, Occurrence and ...
Monoamine oxidase B
"Chalcones: a valid scaffold for monoamine oxidases inhibitors". J. Med. Chem. 52 (9): 2818-24. doi:10.1021/jm801590u. PMID ... Substituted chalcones 2-(N-Methyl-N-benzylaminomethyl)-1H-pyrrole 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine 2 ...
Bidens pilosa
The plant contains the chalcone okanin and ethyl caffeate, a hydroxycinnamic acid. Alternative medicine Chinese classic herbal ...
Aureusidin synthase
In order to modify the chalcone to an aurone, the chalcone must undergo an oxidative cyclization to form a five-member ... and the oxidative cyclization of chalcones to form aurones. The chalcones modified are typically glucosylated 2',4,4',6'- ... This step may not proceed unless the 3-position on the chalcone's B-ring is oxygenated. From this and the protein's homology ... In vitro studies have shown that aurone synthesis proceeds much more quickly when the chalcone is first glucosylated, and in ...
Lipase inhibitors
Some active compounds with chalcone scaffold found in Glycyrrhiza glabra, Cassia mimosoides, Glycyrrhiza uralensis, ... "Efficacy of chalcone and xanthine derivatives on lipase inhibition: A systematic review". Chemical Biology & Drug Design. 95 (2 ...
Daidzein
... which enzymes chalcone synthase (CHS) and chalcone reductase (CHR) modify to obtain trihydroxychalcone. CHR is NADPH dependent ... Chalcone isomerase (CHI) then isomerizes trihydroxychalcone to liquiritigenin, the precursor to daidzein. A radical mechanism ...
Anthochlor pigments
On the one hand, the hydroxytypes of chalcones and aurones, on the other hand the deoxy-types of chalcones and their ... The key to the process is the enzyme chalcone synthase (CHS), which catalyzes the formation of a hydroxyl chalcone from three ... the enzyme chalcone 3-hydroxylase catalyzes the hydroxylation at the C3-position of the A-ring of chalcones. This additional ... Both, chalcones and aurones are known as anthochlor pigments. Anthochlor pigments serve as UV nectar guides in some plants. ...
Physicochemical Studies on Thienyl Chalcone Derivative for Nonlinear Optical Application
... A. N. Prabhu. ,1A. Jayarama. ,2K. ... G. J. Zhang, T. Kinoshita, K. Sasaki, Y. Goto, and M. Nakayama, "Second-harmonic generation of a new chalcone-type crystal," ... J. Indira, P. P. Karat, and B. K. Sarojini, "Growth, characterization and nonlinear optical property of chalcone derivative," ... Recently, we have reported crystal structures and second or third order nonlinear optical properties of few chalcone ...
View topic - 'hesperidin methyl chalcone' & 'hesperidin methyl' - Smart Skin Care
Hesperidin methyl chalcone is a soluble form of Hesperidin. My questions is: Is hesperidin methyl chalcone the same as ... Chalcone is an organic molecule, which, apparently, is attached to hesperidin in hesperidin methyl chalcone.. ... Posted: Wed Feb 15, 2006 2:14 am Post subject: hesperidin methyl chalcone & hesperidin methyl. ...
Alkaline-catalyzed Synthesis of Triarylpyrazolines by Condensation of Chalcones<...
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Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators - University of Regensburg Publication Server
Chalcone-containing tariquidar analogues are promising modulators to aid in functional investigations of ABCG2 transporters. ... To overcome this, we synthesized a novel series of chalcone- and ketone-based compounds inspired by reported tariquidar ... When compared to transporters ABCB1 and ABCC1, the chalcone-based compounds exhibited selectivity for ABCG2, while the ketone- ... From the former series, chalcone 16d (UR-DP48) displayed similar activity to the reference fumitremorgin C, both producing ...
NARINGENIN CHALCONE | SelfDecode | Genome Analysis
Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones - In Vitro and In Silico Study - CROSBI
Chalcones are polyphenolic secondary metabolites of plants, many of which have antioxidant activity. Herein, a set of 26 ... Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones - In Vitro and In Silico Study // Antioxidants, 8 ... Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones - In Vitro and In Silico Study // Antioxidants, 8 ... Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones - In Vitro and In Silico Study. Stepanić, Višnja ...
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Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives | Abdula | European Journal of Chemistry
Abdula, A. Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives. Eur. J. Chem. 2013, 4(3), 207- ... Abdula, A. (2013). Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives. European Journal of ... "Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives." European Journal of Chemistry [Online], ... "Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives" European Journal of Chemistry [Online], ...
PDF) Synthesis Ferrocenyl Chalcone - PDFSLIDE.NET
8/9/2019 Synthesis Ferrocenyl Chalcone 1/381Synthesis and characterisation offerrocenyl chalconeA DissertationSubmitted in ... Modification Structure of Chalcone Compounds and Synthesis ... Structure of Chalcone... · Modification Structure of Chalcone ... Solvent Free Synthesis of Chalcones and their Antibacterial ...free synthesis and melting point of the chalcones. Chalcone with ... Ferrocenyl chalcones belong to a chalcone family in which one or both the aromatic group is ...
REB TECHNOLOGY | Hesperidin Methyl Chalcone (HMC)
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Medicinal Grade Hesperidin Methyl Chalcone Powder Increasing Capillary Resistance
Chinas leading Medicinal Grade Hesperidin Methyl Chalcone product, with strict quality control Powdery Hesperidin Methyl ... High quality Medicinal Grade Hesperidin Methyl Chalcone Powder Increasing Capillary Resistance from China, ... 3. Methyl Chalcone Powder can help lower cholesterol levels. 4. Methyl Chalcone Powder can improve impaired memory loss and ... 1. Methyl Chalcone Powder can enhance the movement of the intestines. 2. Methyl Chalcone Powder can promote digestive secretion ...
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Spectral Properties of Chalcones II. | AVESİS
ANTIOXIDANT STUDIES ON MONOSUBSTITUTED CHALCONE DERIVATIVES - UNDERSTANDING SUBSTITUENT EFFECTS - JatsTech
IMSEAR at SEARO: Novel aminoalkylated chalcone: Synthesis, biological evaluation, and docking simulation as potent antimalarial...
Three chalcone derivatives with amine groups (4a-c) were synthesized and evaluated for their antimalarial activity.Three ... Novel aminoalkylated chalcone: Synthesis, biological evaluation, and docking simulation as potent antimalarial agents. Journal ... Thus, aminoalkylated chalcone couldbe proposed for further studies and developed into antimalarial drug candidates. ... Novel aminoalkylated chalcone: Synthesis, biological evaluation, and docking simulation as potent antimalarial agents. ...
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Doctor's Best Hesperidin Methyl Chalcone, Vegetarian, 500 mg, 60 Veggi - Wellica
Doctors Best Hesperidin Methyl Chalcone, Vegetarian, 500 mg, 60 Veggie Caps ... Best hesperidin methyl chalcone, sourced from Spain, is a flavonoid derived from citrus fruits that many experts believe has ... Details: Best hesperidin methyl chalcone, obtained from a quality source in Spain, is a methylated derivative of the ... the methyl chalcone form was found to be more bioactive than native hesperidin and to work synergistically with vitamin C. ...
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THERMODYNAMICS OF A CHALCONE-BASED POLYMER BY INVERSE GAS CHROMATOGRAPHY METHOD | AVESİS
Chalcones in Bioactive Argentine Propolis Collected in Arid Environments
Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Ferritinophagy. | Chem Biodivers;20(2)...
Thirty-seven novel chalcone-phenazine hybrid molecules (C1â ¼C13 and F1â ¼F24) with 1,2,3-triazole or ethyl group as linkers ... Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Fe ... Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Ferritinophagy. ...
Cloning and catalytic analysis of Isatis indigotica chalcone isomerase in vitro]. | Zhongguo Zhong Yao Za Zhi;48(6): 1510-1517...
Chalcone isomerase is a key rate-limiting enzyme in the biosynthesis of flavonoids in higher plants, which determines the ... Cloning and catalytic analysis of Isatis indigotica chalcone isomerase in vitro].. Zhang, Ke-Ke; Sun, Shu-Fu; Tan, Yu-Ping; Xu ... This study has confirmed the function of chalcone isomerase in I. indigotica and provided references for the biosynthesis of ... Specific primers with enzyme restriction sites were designed, and a chalcone isomerase gene was cloned from I. indigotica, ...
Solvent-Free Synthesis and Antimicrobial Potential of Some (2E)-4-methoxyphenyl Chalcones
Chalcones have been isolated from artificially and natural process. Chalcones are key intermediates for carbon building blocks ... Chalcone possess carbonyl as well as C=C parts in their structure and are called as enones or α, β-unsaturated carbonyl ... All chalcones except 4-CH3 substituent showed good antibacterial activity against S. aureus strain. The ketones have H, 3-Cl, 4 ... All chalcones except 4-CH3 substituent showed good antibacterial activity against S. aureus strain. Here the hyper conjugative ...
Recombinant Glycine max Chalcone--flavonone isomerase 2-A (CHI2-A) | Technique alternative | 01015974393 - hla-a.com
Proanthocyanidin - Wikipedia
Condensed tannins may be characterised by a number of techniques including depolymerisation, asymmetric flow field flow fractionation or small-angle X-ray scattering. DMACA is a dye that is particularly useful for localization of proanthocyanidin compounds in plant histology. The use of the reagent results in blue staining.[17] It can also be used to titrate proanthocyanidins. Proanthocyanidins from field beans (Vicia faba)[18] or barley[19] have been estimated using the vanillin-HCl method, resulting in a red color of the test in the presence of catechins or proanthocyanidins. Proanthocyanidins can be titrated using the Procyanidolic Index (also called the Bates-Smith Assay). It is a testing method that measures the change in color when the product is mixed with certain chemicals. The greater the color changes, the higher the PCOs content is. However, the Procyanidolic Index is a relative value that can measure well over 100. Unfortunately, a Procyanidolic Index of 95 was erroneously taken to ...
Derivatives8
- Chalcone derivatives are one of the interesting groups of materials as they are exhibiting high NLO coefficients and good crystallizability [ 6 ]. (hindawi.com)
- Recently, we have reported crystal structures and second or third order nonlinear optical properties of few chalcone derivatives having thienyl group [ 12 , 13 ]. (hindawi.com)
- Herein, a set of 26 synthetic chalcone derivatives with alkyl substituted pyrazine heterocycle A and four types of the monophenolic ring B, were evaluated for the potential radical scavenging and antioxidant cellular capacity influencing the growth of cells exposed to H2O2. (irb.hr)
- Three chalcone derivatives with amine groups (4a-c) were synthesized and evaluated for their antimalarial activity.Three aminoalkylated chalcone derivatives (4a-c) have been prepared through Claisen-Schmidt condensation reactionfrom vanillin and chloroacetophenone, followed by the Mannich reaction to add amine group. (who.int)
- A ten-membered chalcone library - comprising nine monosubstituted derivatives and the unsubstituted parent chalcone - characterized by varying stereoelectronic properties was screened for antioxidant activity using four well established in vitro assays including the hydrogen peroxide, nitric oxide and super oxide radical scavenging assays along with reducing power assay. (jatstech.org)
- Browsing Indonesia Journal of Pharmacy by Subject "Computer-aided drug design, virtual screening, chalcone derivatives, acetylcholinesterase, Alzheimer's disease. (kemkes.go.id)
- Recently, new chalcone derivatives termed the Chana series were synthesized. (elsevier.com)
- The effect of three chalcone derivatives namely, (E)-ethyl 2-(4-(3-(4-fluorophenyl)acryloyl)phenoxy)acetate (AE-1), (E)-ethyl 2-(4-(3-(3,4-dichlorophenyl)acryloyl)phenoxy)acetate (AE-2) and (E)-ethyl 2-(4-(3-(2,5-dimethoxyphenyl)acryloyl)phenoxy)acetate (AE-3) on the mild steel (MS) corrosion in 1.0 M HCl at 303 K has been investigated using experi. (researchgate.net)
Isomerase5
- Cloning and catalytic analysis of Isatis indigotica chalcone isomerase in vitro]. (bvsalud.org)
- Chalcone isomerase is a key rate-limiting enzyme in the biosynthesis of flavonoids in higher plants , which determines the production of flavonoids in plants . (bvsalud.org)
- Specific primers with enzyme restriction sites were designed, and a chalcone isomerase gene was cloned from I. indigotica, named IiCHI. (bvsalud.org)
- Homology analysis showed that IiCHI was closely related to CHI protein of Arabidopsis thaliana and had typical active sites of chalcone isomerase . (bvsalud.org)
- This study has confirmed the function of chalcone isomerase in I. indigotica and provided references for the biosynthesis of flavonoid components. (bvsalud.org)
Synthesis4
- We have also reported synthesis and crystal structure of 1-(5-chlorothiophen-2-yl)-3-(2,4,5-trimethoxyphenyl) prop-2-en-1-one derivative [ 14 ]. (hindawi.com)
- The solvent-free synthesis of three chalcones was carried out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4- methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and pestle. (uitm.edu.my)
- ABSTRACT: This paper summarizes the synthesis, growth and the effect of the position of the substituent in the thienyl ring and also the properties of the grown chalcone crystals, 2-CTP and 3-CTP. (scirp.org)
- Synthesis, antibiotic modifying activity, ADMET study and molecular docking of chalcone (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying MepA efflux pumps. (wjgnet.com)
SYNTHASE1
- Chalcone reductase (CHR) is a key enzyme mediating 5-deoxyisoflavonoid biosynthesis because it catalyzes the production of 6′-deoxychalcone through its effects on the chalcone synthase (CHS)-catalyzed reaction. (elsevier.com)
Derivative1
- Good quality single crystals of an efficient nonlinear optical (NLO) chalcone derivative 1-(5-chlorothiophen-2-yl)-3-(2,3-dichlorophenyl)prop-2-en-1-one (CTDCP) which meets many of the physicochemical requirements like transparency in the entire visible region, thermal stability, mechanical hardness have been achieved. (researchgate.net)
Naringenin chalcone1
- In vitro enzymatic analysis showed that the IiCHI protein could convert naringenin chalcone into naringenin, but could not catalyze the production of liquiritigenin by isoliquiritigenin. (bvsalud.org)
Nonlinear optical1
- Single crystals of 1-(5-chlorothiophen-2-yl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (CTTMP) having nonlinear optical property have been grown by slow evaporation technique. (hindawi.com)
Secondary metabolites1
- Chalcones are polyphenolic secondary metabolites of plants, many of which have antioxidant activity. (irb.hr)
Hesperidin6
- Hesperidin methyl chalcone' is a soluble form of Hesperidin. (smartskincare.com)
- Chalcone is an organic molecule, which, apparently, is attached to hesperidin in hesperidin methyl chalcone. (smartskincare.com)
- Hesperidin Methyl Chalcone (HMC) is the Citrus original products, is a powerful antioxidant like flavonoid. (hzrebtech.com)
- Hesperidin Methyl Chalcone Powder is a major flavonoid found in lemons and sweet oranges as well as in some other fruits and vegetables, and various polyherbal formulations. (citrusextractpowder.com)
- Hesperidin Methyl Chalcone Powder is a metabolite of hesperidin which has better bioavailability. (citrusextractpowder.com)
- Hesperidin Methyl Chalcone is used in Japan, USA, EU. (citrusextractpowder.com)
Ketone2
- When compared to transporters ABCB1 and ABCC1, the chalcone-based compounds exhibited selectivity for ABCG2, while the ketone-based compounds showed only a slight preference for ABCG2. (uni-regensburg.de)
- An aromatic KETONE that forms the core molecule of CHALCONES . (bvsalud.org)
Flavonoid1
- Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure, and possesses many biological activities. (scielo.org)
Vitro1
- In vitro and in silico studies of chalcones derived from natural acetophenone inhibitors of NorA and MepA multidrug efflux pumps in Staphylococcus aureus. (wjgnet.com)
Compounds3
- Several chalcone compounds are reported to crystallize in noncentrosymmetric crystal pattern and provide necessary configuration for NLO activity with two planar benzene rings connected through a conjugated double bond and a carbonyl moiety [ 8 , 9 ]. (hindawi.com)
- Chalcone possess carbonyl as well as C=C parts in their structure and are called as enones or α, β-unsaturated carbonyl compounds. (derpharmachemica.com)
- Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. (uitm.edu.my)
Flavones1
- We consider that the Argentine arid region is appropriate to place hives in order to obtain propolis of excellent quality because the dominant life forms in that environment are shrubby species that produce resinous exudates with a high content of chalcones, flavones and flavonols. (gob.ar)
Molecules2
- The intramolecular charge-transfer feature available in the chalcone allows us to design new molecules substituted for donor or acceptor groups, which gives an understanding of structure-property relationship [ 7 ]. (hindawi.com)
- Chalcones are known to possess good antioxidant properties, and structure activity relationship studies have been effective in designing molecules with better antioxidant profiles. (jatstech.org)
Methyl1
- 5. Methyl Chalcone Powder has the function of Anti-tumor, suppress the proliferation of cancerous cell. (citrusextractpowder.com)
INHIBITORS1
- Chalcones Isolated from Arrabidaea brachypoda Flowers as Inhibitors of NorA and MepA Multidrug Efflux Pumps of Staphylococcus aureus . (wjgnet.com)
Radical1
- Antioxidants, chalcone, radical scavenging activity and reactive oxygen species. (jatstech.org)
Trans1
- A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4. (chemspider.com)
Interactions1
- In this study, an inverse gas chromatography (IGC) study of thermodynamic interactions of a chalcone modified poly (styrene) based polymer (PVBC-DMAC) with some solvents was presented. (yildiz.edu.tr)
Protein1
- A cell-permeable boranyl-chalcone that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex. (emdmillipore.com)
Activity2
- From the former series, chalcone 16d (UR-DP48) displayed similar activity to the reference fumitremorgin C, both producing comparable maximal effects. (uni-regensburg.de)
- The addition of morpholine (4a), piperidine (4b), and diethylamine (4c) as amine groups significantlycould improve the antimalarial activity with IC50 of 0.62, 0.54, and 1.12 µM, respectively (strong activity), comparedwith the chalcone without amine group (3) with IC50 of 25.84 µM (moderate activity). (who.int)
Organic1
- Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in this study three different chalcones were synthesized using a solventless procedure. (uitm.edu.my)
Reaction1
- Chalcones were obtained in high yields (76-86%), high purity, and shorter reaction time (within five minutes). (uitm.edu.my)
Properties1
- Spectral Properties of Chalcones II. (sdu.edu.tr)
Natural1
- Chalcones have been isolated from artificially and natural process. (derpharmachemica.com)
Group1
- chalcone substituted by a hydroxy group at position 4. (chemspider.com)