Chalcone. Medical search

Compounds based on CHALCONE. They are important intermediates in the formation of FLAVONOIDS.

Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.

Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (From Enzyme Nomenclature, 1992) EC 5.5.

Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots.

An enzyme that catalyzes the deamination of PHENYLALANINE to form trans-cinnamate and ammonia.

A group of FLAVONOIDS characterized with a 4-ketone.

A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.

A plant genus of the family MORACEAE that is widely planted for shade.

A plant genus in the CANNABACEAE family. Best known for the buds of Humulus lupulus L. used in BEER.

A group of phenyl benzopyrans named for having structures like FLAVONES.

A plant genus of the family Apiaceae.

A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).

Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.

A group of compounds which can be described as benzo-pyrano-furano-benzenes which can be formed from ISOFLAVONES by internal coupling of the B ring to the 4-ketone position. Members include medicarpin, phaseolin, and pisatin which are found in FABACEAE.

A sulfuric acid dimer, formed by disulfide linkage. This compound has been used to prolong coagulation time and as an antidote in cyanide poisoning.

Mercury-containing benzoic acid derivatives.

A group of 3-hydroxy-4-keto-FLAVONOIDS.

The photography of images produced on a fluorescent screen by X-rays.

The functional hereditary units of PLANTS.

A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.

A plant family of the order Rhamnales, subclass Rosidae class Magnoliopsida. The plants have a characteristic silvery or rusty-colored sheen, caused by tiny distinctive scales. Flowers have a tubular structure of four sepals. Root nodules host the Frankia (ACTINOMYCETES) nitrogen-fixing symbionts.

Coloration or discoloration of a part by a pigment.

Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.

Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.

A plant species of the family FABACEAE widely cultivated for ANIMAL FEED.

An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.

A plant genus of the family EUPHORBIACEAE. Members contain fredelin type TRITERPENES, mallorepine (a cyano-pyridone), and hydrolyzable TANNINS.

An order of the ANGIOSPERMS, subclass Rosidae. Its members include some of the most known ornamental and edible plants of temperate zones including roses, apples, cherries, and peaches.

A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate.

The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. EC 4.3.1.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.

A plant genus of the family ZINGIBERACEAE. Members contain galangin, yakuchinone-A, and diarylheptanoids.

A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.

A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.

A plant genus of the family ASTERACEAE. Members contain CHALCONE, helichrysetin, arenarin, and flamin.

A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.

Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.

The reproductive organs of plants.

An extensive order of basidiomycetous fungi whose fruiting bodies are commonly called mushrooms.

A group of 4-keto-FLAVONOIDS.

A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Deoxyribonucleic acid that makes up the genetic material of plants.

A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.

A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.

A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.

Keto-pyrans.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

Ribonucleic acid in plants having regulatory and catalytic roles as well as involvement in protein synthesis.

The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.

Organic compounds that contain 1,2-diphenylethylene as a functional group.

That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.

The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)

An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.

Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.

Field of chemistry that pertains to immunological phenomena and the study of chemical reactions related to antigen stimulation of tissues. It includes physicochemical interactions between antigens and antibodies.

A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.

Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.

The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

The relationships of groups of organisms as reflected by their genetic makeup.

Substances that reduce or suppress INFLAMMATION.

Use of plants or herbs to treat diseases or to alleviate pain.

A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The characteristic three-dimensional shape of a molecule.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

A cell line derived from cultured tumor cells.

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

The rate dynamics in chemical or physical systems.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

Diseases of plants.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.

Proteins prepared by recombinant DNA technology.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (1/163)

2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs. (+info)

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (2/163)

The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions. (+info)

Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages. (3/163)

In a previous work, we tested a series of chalcone derivatives as possible anti-inflammatory compounds. We now investigate the effects of three of those compounds, CHI, CH8 and CH12, on nitric oxide and prostanoid generation in mouse peritoneal macrophages stimulated with lipopolysaccharide and in the mouse air pouch injected with zymosan, where they showed a dose-dependent inhibition with inhibitory concentration 50% values in the microM range. This effect was not the consequence of a direct inhibitory action on enzyme activities. Our results demonstrated that chalcone derivatives inhibited de novo inducible nitric oxide synthase and cyclooxygenase-2 synthesis, being a novel therapeutic approach for inflammatory diseases. (+info)

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. (4/163)

Our previous studies have shown that licochalcone A, an oxygenated chalcone, has antileishmanial and antimalarial activities, and alters the ultrastructure and function of the mitochondria of Leishmania spp. parasites. The present study was designed to investigate the antileishmanial activity and the mechanism of action of a group of new oxygenated chalcones. The tested oxygenated chalcones inhibited the in-vitro growth of Leishmania major promastigotes and Leishmania donovani amastigotes. Treatment of hamsters infected with L. donovani with intraperitoneal administration of two oxygenated chalcones resulted in a significant reduction of parasite load in the liver and the spleen compared with untreated control animals. The oxygenated chalcones also inhibited the respiration of the parasite and the activity of mitochondrial dehydrogenases. Electron microscopic studies illustrated that they altered the ultrastructure of the mitochondria of L. major promastigote. The data clearly indicate that this group of oxygenated chalcones has a strong antileishmanial activity and might be developed into a new antileishmanial drug. The antileishmanial activity of oxygenated chalcones might be the result of interference with function of the parasite mitochondria. (+info)

Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. (5/163)

Cytochrome P-450-derived epoxyeicosatrienoic acids (EETs) are avidly incorporated into and released from endothelial phospholipids, a process that results in potentiation of endothelium-dependent relaxation. EETs are also rapidly converted by epoxide hydrolases to dihydroxyeicosatrienoic acid (DHETs), which are incorporated into phospholipids to a lesser extent than EETs. We hypothesized that epoxide hydrolases functionally regulate EET incorporation into endothelial phospholipids. Porcine coronary artery endothelial cells were treated with an epoxide hydrolase inhibitor, 4-phenylchalcone oxide (4-PCO, 20 micromol/l), before being incubated with (3)H-labeled 14,15-EET (14,15-[(3)H]EET). 4-PCO blocked conversion of 14,15-[(3)H]EET to 14,15-[(3)H]DHET and doubled the amount of radiolabeled products incorporated into cell lipids, with >80% contained in phospholipids. Moreover, pretreatment with 4-PCO before incubation with 14,15-[(3)H]EET enhanced A-23187-induced release of radiolabeled products into the medium. In contrast, 4-PCO did not alter uptake, distribution, or release of [(3)H]arachidonic acid. In porcine coronary arteries, 4-PCO augmented 14,15-EET-induced potentiation of endothelium-dependent relaxation to bradykinin. These data suggest that epoxide hydrolases may play a role in regulating EET incorporation into phospholipids, thereby modulating endothelial function in the coronary vasculature. (+info)

2'-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha- and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells. (6/163)

Inhibition of expression of cell adhesion molecules (CAM), including intercellular CAM-1 (ICAM-1), vascular CAM-1 (VCAM-1), and E-selectin, has been shown to be important in controlling various inflammatory diseases. The cell adhesion proteins are induced by various inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1, and bacterial lipopolysaccharide. The induction process primarily takes place at the level of transcription, where nuclear factor-kappaB (NF-kappaB) plays a major role. We demonstrate here that 2'-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner. The inhibition by 2'-hydroxychalcone is reversible. 2'-hydroxychalcone inhibits the induction of steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin by tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction, and therefore it may interfere with the transcription of their genes. Because NF-kappaB is a major transcription factor involved in CAM expression, we studied its status in the 2'-hydroxychalcone treated cells. We demonstrate that 2'-hydroxychalcone inhibits the activation of NF-kappaB. These results have implications for using NF-kappaB inhibitors for the treatment of various inflammatory diseases. (+info)

Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L. (7/163)

The flavonoid constituents in fresh florets of the three distinctive cultivars of Carthamus tinctorius L. were purified and identified to investigate flavonoid biosynthesis in the petals. From the orange flower of cv. Kenba (K.), four new compounds, anhydrosafflor yellow B (1), two kaempferols, 9 and 13, and a quercetin, 17, were isolated, as well as the twelve known compounds, and their structures were determined by spectral data, chemical reactions, and molecular mechanics calculations. From the yellow flower of cv. Ogon-hanagasa (O.), two flavonols and two quinochalcones, and from the white flower of cv. Shiro-bana (S.), three flavonois were isolated. These compounds were the same as those contained in cv. K. To compare the flavonoid constituents among the three cultivars, crude extracts were analyzed by a LC/PDA/MS system. In cv. K., six quinochalcones and eleven flavonols were identified. In cv. O., three quinochalcones and nine flavonols were identified, but the red pigment, carthamin (4), and its precursor, precarthamin (3), were not detected. In cv. S., four flavonols without a 6-hydroxyl group were identified. On the basis of a comparative study on the constituents among these three cultivars, a possible biosynthetic pathway to form quinochalcones via the intermediate, pentahydroxychalcone (19), is proposed. (+info)

Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions. (8/163)

Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, obtained by alkaline hydrogenation of neohesperidin. In this investigation a supposed taste enhancing effect of this substance was tested. A three-step procedure was used. In the first experiment, using a pool of 31 subjects, NHDC and sucrose detection thresholds were measured. In the second experiment, psychophysical functions for both tastants were determined. Then, 15 participants closest to the group threshold who, in addition, had produced monotonic psychophysical taste functions were selected to participate in the next two experiments. In the third experiment, taste enhancement was tested. Three psychophysical sucrose functions were constructed, one with a near-threshold amount of NHDC added to each of seven sucrose concentrations, one with a near-threshold amount of sucrose added (control 1) and one without any addition (control 2). No difference was found between the NHDC-enriched sucrose function and the sucrose-enriched sucrose function. Finally, in experiment 4, differential threshold functions were constructed with either NHDC or sucrose added. Neither the overall shape of the functions nor a comparison of the points of subjective equality showed enhancement. It was concluded that weak NHDC does not enhance the taste of aqueous sucrose solutions. (+info)

Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. In aurones, the ... Chalcone synthase is an enzyme responsible for the production of chalconoids in plants. Chalcone isomerase is responsible for ... Chalcones are also natural aromatase inhibitors. Chalcones are aromatic ketones with two phenyl rings that are also ... Chalconoids Greek: χαλκός khalkós, "copper", due to its color), also known as chalcones, are natural phenols related to ...

https://en.wikipedia.org/wiki/Chalconoid

Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...

https://en.wikipedia.org/wiki/Phytosteroid

Many molecules that are considered to be "dietary fiber" are so because humans lack the necessary enzymes to split the glycosidic bond and they reach the large intestine. Many foods contain varying types of dietary fibers, all of which contribute to health in different ways. Dietary fibers make three primary contributions: bulking, viscosity and fermentation.[49] Different fibers have different effects, suggesting that a variety of dietary fibers contribute to overall health. Some fibers contribute through one primary mechanism. For instance, cellulose and wheat bran provide excellent bulking effects, but are minimally fermented. Alternatively, many dietary fibers can contribute to health through more than one of these mechanisms. For instance, psyllium provides bulking as well as viscosity. Bulking fibers can be soluble (i.e., psyllium) or insoluble (i.e., cellulose and hemicellulose). They absorb water and can significantly increase stool weight and regularity. Most bulking fibers are not ...

https://en.wikipedia.org/wiki/Dietary_fibre

In soils, it is assumed that larger amounts of phenols are released from decomposing plant litter rather than from throughfall in any natural plant community.[citation needed] Decomposition of dead plant material causes complex organic compounds to be slowly oxidized lignin-like humus or to break down into simpler forms (sugars and amino sugars, aliphatic and phenolic organic acids), which are further transformed into microbial biomass (microbial humus) or are reorganized, and further oxidized, into humic assemblages (fulvic and humic acids), which bind to clay minerals and metal hydroxides.[citation needed] There has been a long debate about the ability of plants to uptake humic substances from their root systems and to metabolize them.[citation needed] There is now a consensus about how humus plays a hormonal role rather than simply a nutritional role in plant physiology.[citation needed] In the soil, soluble phenols face four different fates. They might be degraded and mineralized as a carbon ...

https://en.wikipedia.org/wiki/Natural_phenol

... is a chalcone of the chalconoids. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua), Dahlia, ...

https://en.wikipedia.org/wiki/Butein

Another example are chalcones bioisosteres. By modifying certain substituents, the pharmacological activity of the chalcone and ... Comprehensive Pharmacy Review, 6th edition, Leon Shargel, Alan H. Mutnick, p.264 Gomes, Marcelo N. (2017). "Chalcone ...

https://en.wikipedia.org/wiki/Bioisostere

Synthesis of Isoprenyl Chalcone "Sophoradin" Isolated from Sophora subprostrata. Kazuaki Kyogoku, Katsuo Hatayama, Sadakazu ...

https://en.wikipedia.org/wiki/Sophoradin

Kimura, Y.; Aoki, T.; Ayabe, S. (2001). "Chalcone isomerase isozymes with different substrate specificities towards 6′-hydroxy ... "An overexpression of chalcone reductase of Pueraria montana var. lobata alters biosynthesis of anthocyanin and 5′- ...

https://en.wikipedia.org/wiki/Pisatin

Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP (2001). "Structure and mechanism of chalcone synthase- ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Natural Product ...

https://en.wikipedia.org/wiki/Curcumin_synthase

Chalcone synthase (E.C. 2.3.1.74), also known as naringenin-chalcone synthase, is responsible for the reaction: 3 malonyl-CoA ... Both chalcone synthases and stilbene synthases will catalyze the same acyl transfer, decarboxylation, and condensation steps as ... These enzymes are normally classified as either chalcone synthases, stilbene synthases, or type III PKSs. Overall, there are 10 ... However, they will also further cyclize and aromatize the reactions before the final chalcone product is formed. ...

https://en.wikipedia.org/wiki/Ketoacyl_synthase

... (DHC) is a chemical compound related to chalcone. Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′- ...

https://en.wikipedia.org/wiki/Dihydrochalcone

Tetrahydroxychalcone is then converted into naringenin using chalcone isomerase. Naringenin is converted into eriodictyol using ...

https://en.wikipedia.org/wiki/Quercetin

doi:10.1111/j.1095-8339.2011.01198.x. Inda, Luis A.; Pimentel, Manuel & Chase, Mark W. (2010). "Chalcone synthase variation and ...

https://en.wikipedia.org/wiki/Dactylorhiza

Chalcone isomerase (CHI) then isomerizes the product to close the pyrone ring to make naringenin. Finally, a flavanone synthase ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Natural Product ... Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive ... condensations of three equivalents of malonyl CoA followed by aromatization to convert p-coumaroyl-CoA to chalcone. ...

https://en.wikipedia.org/wiki/Apigenin

Other names in common use include chalcone OMT, and CHMT. Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification ...

https://en.wikipedia.org/wiki/Isoliquiritigenin_2'-O-methyltransferase

"Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium saltderivatives" Inorg. Chim. Acta; 2017 ... "Electrochemical and Spectroscopical Characterization of Ferrocenyl Chalcones" Journal of The Electrochemical Society, 2010, 157 ... "Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium salt derivatives". Inorganica Chimica Acta ... "Electrochemical and Spectroscopical Characterization of Ferrocenyl Chalcones". Journal of the Electrochemical Society. 157 (8 ...

https://en.wikipedia.org/wiki/Ingrid_del_Carmen_Montes_González

Epicuticular waxes are basically composed of nonacosan-10-ol.[citation needed] Tetracentron contains chalcones or ...

https://en.wikipedia.org/wiki/Trochodendraceae

... as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on ... Forkmann G, Dangelmayr B (June 1980). "Genetic control of chalcone isomerase activity in flowers of Dianthus caryophyllus". ...

https://en.wikipedia.org/wiki/Chemogenetics

"Chalcones: a valid scaffold for monoamine oxidases inhibitors". J. Med. Chem. 52 (9): 2818-24. doi:10.1021/jm801590u. PMID ... Substituted chalcones 2-(N-Methyl-N-benzylaminomethyl)-1H-pyrrole 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine 2 ...

https://en.wikipedia.org/wiki/Monoamine_oxidase_B

The plant contains the chalcone okanin and ethyl caffeate, a hydroxycinnamic acid. Extracts of B. pilosa suppressed the growth ...

https://en.wikipedia.org/wiki/Bidens_pilosa

In order to modify the chalcone to an aurone, the chalcone must undergo an oxidative cyclization to form a five-member ... and the oxidative cyclization of chalcones to form aurones. The chalcones modified are typically glucosylated 2',4,4',6'- ... This step may not proceed unless the 3-position on the chalcone's B-ring is oxygenated. From this and the protein's homology ... In vitro studies have shown that aurone synthesis proceeds much more quickly when the chalcone is first glucosylated, and in ...

https://en.wikipedia.org/wiki/Aureusidin_synthase

Some active compounds with chalcone scaffold found in Glycyrrhiza glabra, Cassia mimosoides, Glycyrrhiza uralensis, ... "Efficacy of chalcone and xanthine derivatives on lipase inhibition: A systematic review". Chemical Biology & Drug Design. 95 (2 ...

https://en.wikipedia.org/wiki/Lipase_inhibitors

... which enzymes chalcone synthase (CHS) and chalcone reductase (CHR) modify to obtain trihydroxychalcone. CHR is NADPH dependent ... Chalcone isomerase (CHI) then isomerizes trihydroxychalcone to liquiritigenin, the precursor to daidzein. A radical mechanism ...

https://en.wikipedia.org/wiki/Daidzein

On the one hand, the hydroxytypes of chalcones and aurones, on the other hand the deoxy-types of chalcones and their ... The key to the process is the enzyme chalcone synthase (CHS), which catalyzes the formation of a hydroxyl chalcone from three ... the enzyme chalcone 3-hydroxylase catalyzes the hydroxylation at the C3-position of the A-ring of chalcones. This additional ... Both, chalcones and aurones are known as anthochlor pigments. Anthochlor pigments serve as UV nectar guides in some plants. ...

https://en.wikipedia.org/wiki/Anthochlor_pigments

True polyphenols from the tannin and other WBSSH types are routinely biosynthesized in the natural sources from which they derive; their 'chemical' syntheses (using standard "bench" organic chemical methods) were somewhat limited until the first decade of the new millennium because these syntheses involve challenging regioselectivity and stereoselectivity issues.[11] Early work focused on the achiral synthesis of phenolic-related components of polyphenols in the late 70's,[12] and the Nelson and Meyers synthesis of the permethyled derivative of the ubiquitous diphenic acid core of ellagitannins in 1994[13] followed by stereoselective synthesis of more complex permethylated structures such as a (+)-tellimagrandin II derivative by Lipshutz and coworkers in the same year,[14] and Itoh and coworker's synthesis of a permethylated pedunculagin with particular attention to axial symmetry issues in 1996.[15] The total synthesis of a fully unmasked polyphenol, that of the ellagitannin tellimagrandin I, ...

https://fa.wikipedia.org/wiki/پلی_فنول?match=en

Likewise, two chalcone tetramers were isolated as inhibitors of Epstein-Barr virus (EBV)-activation induced by a tumor promoter ... Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters. Murakami A, Tanaka ...

https://en.wikipedia.org/wiki/Lophira_alata

"4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates". Phytochemistry. 49 (7): 1945- ...

https://en.wikipedia.org/wiki/Phloroisovalerophenone_synthase

The hydroperoxide anion and chalcone assemble in a complex with the poly-leucine catalyst before reacting to form a peroxide ... doi:10.1039/B404390C Carrea, G.; Colonna, S.; Meek, A. D.; Ottolina, G.; Roberts, S. M., "Kinetics of chalcone oxidation by ... The Juliá-Colonna epoxidation of electron-deficient olefins was originally demonstrated with chalcones, but it was soon ... the chalcone substrate is soluble in the organic phase, generally toluene or carbon tetrachloride. The alkaline hydrogen ...

https://en.wikipedia.org/wiki/Juliá–Colonna_epoxidation

Chalcone synthase, the first enzyme of this pathway, produces chalcone from 4-coumaroyl-CoA. All flavonoids are derived from ... this chalcone backbone (this family being the so-called chalconoids). The activity of different enzymes, including isomerases ...

https://en.wikipedia.org/wiki/Fisetin

... and this is then combined with malonyl-CoA to produce chalcones which are backbones of Flavonoids Chalcones are aromatic ... The closure of chalcones causes the formation of the flavonoid structure. Flavonoids are also closely related to flavones which ...

https://en.wikipedia.org/wiki/Plant_secondary_metabolism

cis-chalcone (CHEBI:48966) is a chalcone (CHEBI:27618). trans-chalcone (CHEBI:48965) is a chalcone (CHEBI:27618). ... chalcone (CHEBI:27618) has role plant metabolite (CHEBI:76924) chalcone (CHEBI:27618) is a chalcones (CHEBI:23086) chalcone ( ... CHEBI:27618 - chalcone. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene ...

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27618

phlorizin chalcone (CHEBI:80486) is a chalcones (CHEBI:23086). pinocembrin chalcone (CHEBI:80484) is a chalcones (CHEBI:23086) ... chalcones (CHEBI:23086) is a aromatic ketone (CHEBI:76224) chalcones (CHEBI:23086) is a enone (CHEBI:51689) chalcones (CHEBI: ... Pinostrobin chalcone (CHEBI:174555) is a chalcones (CHEBI:23086). Pongachalcone I (CHEBI:180260) is a chalcones (CHEBI:23086). ... chalcone (CHEBI:27618) is a chalcones (CHEBI:23086). Citrunobin (CHEBI:175512) is a chalcones (CHEBI:23086). Crassichalcone ( ...

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:23086

Chalcones have two absorption maximums at 280 nm and 340 nm. Chalcones can be prepared by an aldol condensation between ... The specific case for formation of 3,5-diphenyl-1H-pyrazole from chalcone itself can be represented as: Chalcones and their ... Chalcone complexes have also been reported. Several natural and (semi) synthetic chalcones have shown anti-cancer activity due ... "Photochemistry of chalcone and the application of chalcone-derivatives in photo-alignment layer of liquid crystal display". ...

https://en.wikipedia.org/wiki/Chalcone

Glycine max chalcone synthase (CHS8), mRNA Glycine max chalcone synthase (CHS8), mRNA. gi,1205914835,ref,NM_001317656.2, ... Soybean chalcone isomerase: evolution of the fold, and the differential expression and localization of the gene family. [Planta ... Soybean chalcone isomerase: evolution of the fold, and the differential expression and localization of the gene family.. ...

https://www.ncbi.nlm.nih.gov/nuccore/NM_001317656

Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of ... Cain CC, Saslowsky DE, Walker RA, Shirley BW (October 1997). "Expression of chalcone synthase and chalcone isomerase proteins ... Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. 4-coumaroyl-CoA ... Other light sensitive domains include Box I, Box II, Box III, Box IV or three copies of H-box (CCTACC). The chalcone synthase ...

https://en.wikipedia.org/wiki/Chalcone_synthase

Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...

https://echa.europa.eu/substance-information/-/substanceinfo/100.002.119

Chalcone, 2,6-dihydroxy-4-methoxy, bis-TMS. *Formula: C22H30O4Si2 ...

https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C22H30O4Si2/c1-24-18-15-21

Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the ... The flavokawains: uprising medicinal chalcones Cancer Cell Int. 2013 Oct 22;13(1):102. doi: 10.1186/1475-2867-13-102. ... Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the ...

https://pubmed.ncbi.nlm.nih.gov/24148263/

2′,4-Dihydroxy-4′-methoxy chalcone (7): yellow needles, yield 86%, and m.p. 152~153°C; 1H NMR (400 MHz, DMSO-. ): δ 3.95 (3H, s ... Chalcones 28~32 were prepared by using aldol condensation of appropriate substituted benzaldehydes 23~27, 33, 34, and acetyl ... 2′-Hydroxy-3,4,4′-trimethoxy chalcone (8): yellow needles, yield 74%, and m.p. 145~147°C; 1H NMR (400 MHz, CDCl3): δ 3.95 (9H, ... To a solution of chalcones 6~8, 28~32 (0.3 mmol) in methanol (5.5 mL) was, respectively, added 16% NaOH (aq) (0.6 mL), 15% H2O2 ...

https://www.hindawi.com/journals/tswj/2013/649485/

The dipole moments of 24 selenophene analogs of the chalcones have been measured and have been compared with the data ... Organic Chemistry Ketone Dipole Moment Chalcones Conformational State This is a preview of subscription content, log in to ... The dipole moments of 24 selenophene analogs of the chalcones have been measured and have been compared with the data ...

https://link.springer.com/article/10.1007/BF00475841

... also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. ... IPR012328. Chalcone/stilbene_synth_C. IPR018088. Chalcone/stilbene_synthase_AS. IPR001099. Chalcone/stilbene_synthase_N. ... IPR012328. Chalcone/stilbene_synth_C. IPR018088. Chalcone/stilbene_synthase_AS. IPR001099. Chalcone/stilbene_synthase_N. ... The primary product of this enzyme is 4,2,4,6-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can ...

http://www.uniprot.org/uniprot/P30079

... Ketan Mistry and K. R. Desai ... And this series of chalcones have been synthesised by the reaction of 2-acetylhydrazinomethyl-3-(substitutedphenyl)-quinazoline ... have been synthesised by the condensation of p-nitro phenylurea and various chalcones, 2-(substituted ...

https://www.hindawi.com/journals/jchem/2005/690296/abs/

RNA-mediated RNA degradation and chalcone synthase A silencing in petunia.. Metzlaff M1, ODell M, Cluster PD, Flavell RB. ... Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone ...

https://www.ncbi.nlm.nih.gov/pubmed/9118227?dopt=Abstract

Responsible for the isomerization of 4,2,4,6-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity). ... Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. ... IPR016087 Chalcone_isomerase. IPR016088 Chalcone_isomerase_3-sand. IPR016089 Chalcone_isomerase_bundle_sf. IPR036298 Chalcone_ ... IPR016087 Chalcone_isomerase. IPR016088 Chalcone_isomerase_3-sand. IPR016089 Chalcone_isomerase_bundle_sf. IPR036298 Chalcone_ ...

https://www.uniprot.org/uniprot/Q3Y4F4

... Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ... Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ... Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis ...

http://www.pnas.org/content/115/22/E5223.short?rss=1

Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. ... Structural insights into a novel anticancer sulfonamide chalcone J. M. F. Custodio, L. J. Michelini, M. R. C. de Castro, W. F. ... We show that the BSC compound has a planar conformation in its chalcone portion, which is further corroborated by the low angle ... Herein, we report the synthesis and structural elucidation of a novel sulfonamide chalcone 2,5-dichloro-N-{3-[(2E)-3-(4- ...

https://pubs.rsc.org/en/content/articlelanding/2018/nj/c7nj03523c

... the chalcone isomers, i.e., trans-chalcone (1) and cis-chalcone (2), the Michael addition product (1,3,5-triphenylpentan-1-5- ... When toluene is used as solvent, trans-chalcone (1), cis-chalcone (2) and Michael addition product (3) were formed (Figure 6C ... LDH-rGO-20 and LDH-rGO-10 lead to the higher yields of trans-chalcone (1) and cis-chalcone (2), respectively and, most ... When methanol is used as solvent cis-chalcone (2), trans-chalcone (1) and aldol (4) are only obtained while the Michael ...

https://www.mdpi.com/2305-7084/3/1/29/htm

Chalcone could produce two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about -0.689 V. The differential ... differential pulse and square wave voltammetric techniques for the determination of trace-level chalcone at a glassy carbon ... Chalcone could produce two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about -0.689 V. The differential ... O. V. Yarishkin, W. R. Hyung, P. Jae-Yong, S. Y. Min, H. Seong-Geun and H. P. Ki, "Sulfonate Chalcone as New Class Voltage- ...

http://www.scirp.org/journal/paperinformation.aspx?paperid=23128

... chalcone explanation free. What is chalcone? Meaning of chalcone medical term. What does chalcone mean? ... Looking for online definition of chalcone in the Medical Dictionary? ... chalcone. Also found in: Wikipedia. chal·cone. (kalkōn), The parent compound of a series of plant pigments. All are flavonoids ... lactiflora, including phenylalanine ammonialyase gene (PAL), chalcone synthase gene (CHS), chalcone isomerase gene (CHI), F3H, ...

http://medical-dictionary.thefreedictionary.com/chalcone

Chalcone and four chalcone analogues 1a-d were evaluated using zebrafish embryos following antibody staining to visualize their ... Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on ... The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. ... The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone ...

https://www.mdpi.com/1420-3049/19/1/641

Chalcones explanation free. What is Chalcones? Meaning of Chalcones medical term. What does Chalcones mean? ... Looking for online definition of Chalcones in the Medical Dictionary? ... chalcone. (redirected from Chalcones) chal·cone. (kalkōn), The parent compound of a series of plant pigments. All are ... Chalcones , definition of Chalcones by Medical dictionary https://medical-dictionary.thefreedictionary.com/Chalcones ...

https://medical-dictionary.thefreedictionary.com/Chalcones

Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. However, the ... Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids (5d-7j, 9d-11f, 12k-13m) against AChE and BChE. ... Coumarin Chalcone Cholinesterase inhibitors Structure-activity relationship Tertiary amine group Electronic supplementary ... Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. However, the ...

https://link.springer.com/article/10.1007%2Fs11030-018-9839-y

Chalcone derivatives exhibit a broad spectrum of pharmacological activities, such as immunomodulation, as well as anti- ... This review highlights the effects of chalcone derivatives in different types of immune cells. Keywords: macrophages, ... Effects of chalcone derivatives on players of the immune system Jian Sian Lee, Syed Nasir Abbas Bukhari, Norsyahida Mohd Fauzi ... Effects of chalcones in T cells. In work investigating the role of chalcones in T cells, these were found to inhibit the ...

https://www.dovepress.com/front_end/effects-of-chalcone-derivatives-on-players-of-the-immune-system-peer-reviewed-fulltext-article-DDDT

TALIA, Juan Manuel; DEBATTISTA, Nora Beatriz and PAPPANO, Nora Beatriz. New antimicrobial combinations: substituted chalcones- ... Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. ... The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with ...

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-83822011000200010&lng=en&nrm=iso&tlng=en

All synthesized chalcone compounds could be taken to visualize hH3R proteins in stably transfected HEK-293 cells using confocal ... All synthesized chalcone compounds could be taken to visualize hH3R proteins in stably transfected HEK-293 cells using confocal ... Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH3R in the same concentration range ... Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH3R in the same concentration range ...

https://www.frontiersin.org/articles/10.3389/fnsys.2012.00014/full

... complexes having chalcone or flavonol ligands and Schiff base (N-phenyl-5-chlorosalicylideneimine) as co-ligand were prepared, ... Copper(II) chalcone complexes, with square-pyramidal CuO4N core, are binuclear, featuring phenolate oxygen from the Schiff base ... Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like ... "Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like ...

https://hrcak.srce.hr/202087?lang=en

Trusted since 1969, we offer trusted quality and great value on Douglas Laboratories Hesperidin Methyl Chalcone 60 Caps ... Shop the best Douglas Laboratories Hesperidin Methyl Chalcone 60 Caps products at Swanson Health Products. ... Hesperidin Methyl Chalcone from Douglas Laboratories supports circulation health. This methylated form of the flavonoid ...

https://www.swansonvitamins.com/douglas-laboratories-hesperidin-methyl-chalcone-60-caps

... and ratiometric fluorescence responses for Fe3+ by a symmetric chalcone analogue (receptor 1). The key step behind NIR ... chalcone. analogue U. Diwan, A. Kumar, V. Kumar and K. K. Upadhyay, Dalton Trans., 2013, 42, 13889 DOI: 10.1039/C3DT50733E ... chalcone. analogue (receptor 1). The key step behind NIR chromogenic response was attributed to chelation of Fe3+ with receptor ...

http://pubs.rsc.org/en/Content/ArticleLanding/DT/2013/C3DT50733E

Niesbach-Klösgen, U., E. Barzen, J. Berhardt, W. Rohde, Z. Schwarz-Sommer et al., 1987 Chalcone synthase genes in plants: a ... Franken, P., U. Niesbach-Klosgen, U. Weydemann, L. Marechal-Drouard, H. Saedler et al., 1991 The duplicated chalcone synthase ... AY728478 [c2 gene chalcone synthase (wild type) C2-W22], AY728476 (Zea mays L. C2-Idf allele; gene copies C2-Idf-I and C2-Idf- ... Jorgensen, R. A., P. D. Cluster, J. English, Q. Que and C. A. Napoli, 1996 Chalcone synthase cosuppression phenotypes in ...

https://www.genetics.org/content/170/4/1989?ijkey=0cedb783403ea2f42eb0592e37c38b43022b1f1d&keytype2=tf_ipsecsha

In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which ... Pan Y, Chen Y, Li Q, Yu X, Wang J, Zheng J. The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in ... Pan, Y.; Chen, Y.; Li, Q.; Yu, X.; Wang, J.; Zheng, J. The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone ... In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which ...

http://mdpi.com/1420-3049/18/2/1693

Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. (wikipedia.org)
Type III PKSs are associated with the production of chalcones, a class of organic compounds found mainly in plants as natural defense mechanisms and as synthetic intermediates. (wikipedia.org)
Chalcones are a class of natural compounds that widely exist in a variety of plant species. (hindawi.com)
Despite lots of recent impressive reports on chalcones [ 8 , 9 ] and 5-deoxyflavonoids [ 10 ], the full potential of such class of compounds is yet to be realized in terms of both more new molecules as drugs and varied biological activity. (hindawi.com)
Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. (rsc.org)
Zavrsnik, DFT Study and Microbiology of Some Coumarin-Based Compounds Containing a Chalcone Moiety, J. (thefreedictionary.com)
The induction of chalcone synthase and phenylalanine ammonia-lyase by salicylic acid application which results in the synthesis of certein phenolic compounds that play an important role in conferring resistance against various abiotic stresses including temperature stress (Campos et al, 2003) further supports our results. (thefreedictionary.com)
rufogrisea Chemical class Alkaloids - Phenolic compounds Anthraquinones + Coumarins + Tannins + Xanthones + Flavonoids Aurones - Catechins--Catechin + tannins Flavonoids Chalcones - Flavonols + Flavanones + Terpenoids and steroids Saponins + Alpha, beta-unsaturated lactones + Steroid nuclei + 2-deoxy sugars + The signs (+) and (-) indicate, respectively, the presence or absence of the chemical classes in the analyzed plant material. (thefreedictionary.com)
These species are known to produce many insecticidal compounds such as alkaloids, sesquiterpenes, chalcones , and flavonoids (Romo de Vivar et al. (thefreedictionary.com)
Compounds with para -substituted chalcone fragments in which the substituents were choline-like had potent activity against AChE and poor activity against BChE, while ortho -substituted analogs exhibited an opposite effect. (springer.com)
All synthesized chalcone compounds could be used to visualize hH 3 R proteins in stably transfected HEK-293 cells using confocal laser scanning fluorescence microscopy. (frontiersin.org)
On the other hand, acylhydrazides (a class of compounds structurally related to chalcones) have been successfully investigated against T. cruzi cruzain. (scielo.br)
Kavalactones and chalcones are two main classes of compounds identified from kava extracts ( 12 ). (aacrjournals.org)
Among them, synthesized ionone based chalcones derivatives act as potent antiprostate cancer compounds. (ijpsonline.com)
However, one of the compounds was instead found to stabilize tubulin to the same extent as the known anticancer drug docetaxel, thus representing the first chalcone with microtubule stabilizing activity. (dissertations.se)
A series of novel hydroxy-pyran-chalcone hybrid compounds 4(a-b), 5(a-f), 7(a-b) & 8(a-f) has been synthesized by employing simple methods in various approaches through convergent synthetic strategies. (eurekaselect.com)
To evaluate the hepatotoxic potential of single compounds, six kavalactones were isolated from an acetonic kava root extract and the three kava-chalcones (flavokawains) were obtained by synthesis. (uni-regensburg.de)
Whereas the toxicity of five tested kavalactones was found to be very low (K, M, DMY) or completely absent (DHK, DHM), distinct effects on both cell viability and proliferation were observed for the kavalactone Y and the kava-chalcones, FKB being the most toxic (IC50 ~ 30 µM on HepG2 and IC50 ~ 40 µM on HuH-7) of the test compounds. (uni-regensburg.de)
Background: Structural similarity in Chalcone and Pyrazoline brought our intention for the analysis of such compounds. (lettersindrugdesigndiscovery.com)
Novel anthraquinone based chalcone compounds were synthesized starting from 1-acetylanthraquinone in a Claisen-Schmidt reaction and evaluated for their anticancer potential against three human cancer cell lines. (ac.rs)
Among the screened chalcone derivatives two were selected as potential lead compounds to designpotent inhibitors for acetylcholinesterase: 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one(3k) and 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one (4k). (e-jurnal.com)
Moreover, numerous compounds from the family of dietary chalcones appear to show activity against cancer cells, suggesting that these molecules or their derivatives may be considered as potential anticancer drugs. (biomedcentral.com)
The cytotoxic activity of all compounds synthesized here and of two other related sulfonamide chalcones was also assessed against three cancer cell lines (SF-295, HCT-8 and MDA-MB-435). (ufg.br)

The present study forms a basis for optimizing chalcone derivatives structures to improve their second-order nonlinear optical properties and therma stability. (scirp.org)

Abstract A series of six novel heterocyclic chalcone analogues 4a-f has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. (duhnnae.com)

vsad1 is a previously identified allele of the transparent testa 4 gene ( tt4 ), which encodes chalcone synthase (CHS), a key enzyme involved in the biosynthesis of flavonoids. (springer.com)
Anjari S.S. (2010), "Evaluation of Antioxidant Activity of Chalcones and Flavonoids" International Journal of ChemTech Research, (2), 1080-1089. (pharmatutor.org)
Chalcone synthase (CHS) is the key enzyme in the flavonoids biosynthesis pathway, and has been proved to monitor the changes to drought stress tolerance. (preprints.org)
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. (medchemexpress.com)
Chalcone synthase is a key enzyme in the biosynthesis of flavonoids, including certain phytoalexins derived from a 6′-deoxychalcone which is synthesized by cooperation of chalcone synthase with a reductase. (uni-leipzig.de)

In our continued efforts to use natural products only as synthetic templates and thereby replace the original plant sources with synthetic ones and investigate structure-activity relationship, herein, we wish to report the synthesis and cytotoxicity bioassays of a series of chalcones 1 ~ 8 and 5-deoxyflabonoids 9 ~ 16 as well as their glycoside derivatives 17 ~ 22 . (hindawi.com)
Cytotoxicity of selected novel chalcone derivatives on human breast, lung and hepatic carcinoma cell lines. (thefreedictionary.com)
Masood, Anti-HIV cytotoxicity enzyme inhibition and molecular docking studies of quinoline based chalcones as potential non-nucleoside reverse transcriptase inhibitors (NNRT), Bioorg. (thefreedictionary.com)
The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. (eurekaselect.com)
trans-Chalcone exhibits a pronounced cytotoxicity activity [1] . (medchemexpress.com)
Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. (medchemexpress.com)
Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus. (bioseek.eu)

Soybean chalcone isomerase: evolution of the fold, and the differential expression and localization of the gene family. (nih.gov)
Through FLIM FRET, it was shown that CHS interacts with chalcone isomerase (CHI), a consecutive step enzyme, as well as other non-consecutive step enzymes flavanone 3-hydroxylase (F3H), dihydroflavonol 4-reductase (DFR), and flavonol synthase I. Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2. (wikipedia.org)
Here, we identify two noncatalytic chalcone isomerase-fold proteins, which are critical for high-efficiency prenylchalcone production in Humulus lupulus . (pnas.org)
Our results provide insights into their evolutionary development from the ancestral noncatalytic fatty acid-binding chalcone isomerase-fold proteins to specialized auxiliary proteins supporting flavonoid biosynthesis in plants, and open up the possibility of producing high-value plant prenylchalcones using heterologous systems. (pnas.org)
In this study, we characterized two noncatalytic chalcone isomerase (CHI)-like proteins (designated as HlCHIL1 and HlCHIL2) using engineered yeast harboring all genes required for DMX production. (pnas.org)
Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase. (thefreedictionary.com)
The scientists were able to significantly increase the total flavonol content in both the peel and flesh using the onion chalcone isomerase (CHI) gene. (thefreedictionary.com)
In this study, we establish that chalcone isomerase-like proteins (CHILs), which are encoded by genes that are ubiquitous in land plant genomes, bind to CHS to enhance THC production and decrease CTAL formation, thereby rectifying the promiscuous CHS catalysis. (elsevier.com)

Chalcone synthase or naringenin-chalcone synthase (CHS) is an enzyme ubiquitous to higher plants and belongs to a family of polyketide synthase enzymes (PKS) known as type III PKS. (wikipedia.org)
The enzyme catalyzes the conversion of 4-coumaroyl-CoA and malonyl-CoA to naringenin chalcone. (wikipedia.org)
4-coumaroyl-CoA and three units of malonyl-CoA are converted into three molecules of carbon dioxide, four molecules of coenzyme A and one unit of naringenin chalcone. (wikipedia.org)
After the generation of a thioester-linked tetraketide, a regiospecific C1,C6 Claisen condensation occurs, forming a new ring system to generate naringenin chalcone. (wikipedia.org)
CHS is noncompetitively inhibited by flavanoid pathway products such as naringenin and chalcone naringenin. (wikipedia.org)
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. (uniprot.org)
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO 2 . (uniprot.org)
Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity). (uniprot.org)
Resveratrol and chalcone synthases utilize the same substrates (4-coumaroyl-CoA and 3 molecules of malonyl-CoA ) and catalyze the same condensing type of enzyme reaction (resulting in sequential addition of acetate units via malonyl-CoA ), but the products differ in the newly formed ring systems (resveratrol and naringenin chalcone). (uni-leipzig.de)
Biosynthesis of naringenin chalcone in plants and citruses. (biomedcentral.com)

Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. (thefreedictionary.com)
C2-Idf is a stable dominant mutation of the chalcone synthase gene, c2 , which encodes the first dedicated enzyme in this biosynthetic pathway of maize. (genetics.org)
To assess the possible role of some of the genes potentially involved in cell wall lipid synthesis, we disrupted a mas -like gene, msl7 , and a chalcone synthase-like gene, pks10 , with phage-mediated delivery of the disruption construct, in which the target gene was disrupted by replacement of an internal segment with the hygromycin resistance gene ( hyg ). (asm.org)
UV-B, UV-A, and blue light signal transduction pathways interact synergistically to regulate chalcone synthase gene expression in Arabidopsis. (plantcell.org)
Here, we provide evidence that several distinct "inductive" and "synergistic" UV/blue phototransduction pathways regulate chalcone synthase (CHS) gene transcription and transcript accumulation in Arabidopsis leaf tissue. (plantcell.org)
Weisshaar B, Block A, Armstrong GA, Herrmann A, Schulze-Lefert P, Hahlbrock K. Regulatory elements required for light-mediated expression of the Petroselinum crispum chalcone synthase gene. (uni-bielefeld.de)
Regulatory elements required for light-mediated expression of the Petroselinum crispum chalcone synthase gene", Proceedings of the Society for Experimental Biology and Medicine , vol. 45, 1991, pp. 191-210. (uni-bielefeld.de)
Ashitaba Chalcones help promote the expression of the adiponectin gene and 3t3-l1 adiponectin adipogenesis in order to prevent metabolic syndrome. (dyna-nutrition.com)
Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. (medchemexpress.com)
The effect of gamma irradiation, either as a single elicitor or coupled with salinity, on chalcone synthase (CHS) gene expression and silybin A + B yield was also evaluated. (must.edu.eg)

3) Chalcones possess an interesting pharmacological profile for the treatment of hepatic fibrosis, as they comprise several favorable biological activities such as anti-inflammatory, anti-oxidant, antiviral, and apoptosis-inducing effects. (uni-regensburg.de)
trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. (medchemexpress.com)

Chalcones are the promising candidates in inhibiting various cardiovascular, hematological and anti-obesity targets like angiotensin-converting enzyme (ACE), cholesteryl ester transfer protein (CETP), diacylglycerol acyltransferase (DGAT), acyl-coenzyme A: cholesterol acyltransferase (ACAT), pancreatic lipase (PL), lipoprotein lipase (LPL), calcium (Ca2+)/potassium (K+) channel, thromboxane (TXA2 and TXB2), etc. (wikipedia.org)
One of the structural genes, colorless2 ( c2 ), encodes chalcone synthase, the enzyme responsible for the first dedicated step in the pathway. (genetics.org)
At the enzyme level, the effect on aleurone pigmentation is due to a lack of chalcone synthase enzyme activity ( D ooner 1983 ). (genetics.org)
In the present work, we describe the synthesis and inhibitory effects of a series of thirty-three chalcone and seven hydrazide derivatives against the enzyme cruzain from T. cruzi . (scielo.br)
Amjad, M.W.B. (2013), "Synthesis and evaluation of chalcone analogues based pyrimidines as angiotensinconverting enzyme inhibitors", Pakistan Journal of Biological Science, 16(21), 1368-1372. (pharmatutor.org)
Aslan, G.(2017), "Design of potent fluoro-substituted chalcones as antimicrobial agents", Journal Of Enzyme Inhibition And Medicinal Chemistry, 32(1), 490-495. (pharmatutor.org)
cDNA clones encoding chalcone synthase (CHS) (EC 2.3.1.74), a key enzyme involved in flavonoid and anthocyanin biosynthesis were isolated from a cDNA library constructed from flowers of the orchid, Bromheadia finlaysoniana (Lindl. (nus.edu.sg)
Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic pathway and catalyzes the production of 2′,4,4′,6′-tetrahydroxychalcone (THC). (elsevier.com)

The dipole moments of 24 selenophene analogs of the chalcones have been measured and have been compared with the data calculated by a vectorial additive scheme and also with their chemical structures. (springer.com)
In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free radical activity, and screened their effects on scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro . (mdpi.com)
Pan Y, Chen Y, Li Q, Yu X, Wang J, Zheng J. The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in Vitro Anti-Free Radicals Pharmacological Activity and in Vivo Anti-Oxidation Activity in a Free Radical-Injury Alzheimer's Model. (mdpi.com)
Chalcones and their heterocyclic analogs appreciate a scope of organic exercises, for example, antimicrobial, cancer prevention agent, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and calming exercises which makes these mixes as an extraordinary fascination for examination. (alliedacademies.org)
A series of substituted chalcone oxides (1,3-diphenyl-2-oxiranyl propanones) and structural analogs was synthesized to investigate the mechanism by which they inhibit soluble epoxide hydrolases (sEH). (elsevier.com)

Chalcones are regular item has a place with Flavonoid family. (alliedacademies.org)
Chalcones are a valuable molecule of medicinal importance due to presence of reactive ketoethylenic group -CO-CH=CH-, belonging to the flavonoid family. (pharmatutor.org)
Chalcone synthase (CHS) catalyzes the committed enzymatic step in flavonoid biosynthesis. (uni-bielefeld.de)

Synthesis and Biological Evaluation of Simple Methoxylated Chalcones as Anticancer, Anti-inflammatory and Antioxidant Agents. (thefreedictionary.com)
Chalcone derivatives exhibit a broad spectrum of pharmacological activities, such as immunomodulation, as well as anti-inflammatory, anticancer, antiviral, and antimicrobial properties. (dovepress.com)
This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. (dissertations.se)
This review is focused about different methods of synthesis and versatile biological activity of chalcones including antimicrobial, anticancer, antioxidant, antimalarial, antituberculosis etc. (pharmatutor.org)
trans-Chalcone has antifungal and anticancer activity. (medchemexpress.com)

J. A. Kumar and S. Sondu, "Kinetics and Mechanism of Oxidation of Chalcones by Ti-Ichloroisocyanuric Acid [TCICA] in HOAc-HClO4 Medium," Indian Journal of Chemistry, Vol. 46A, 2007, pp. 1792-1795. (scirp.org)
The kinetics and mechanism of oxidation of chalcone and some substituted chalcones by trichloroisocyanuric acid (TCICA) has been investigated at 313 K in HOAc-HClO₄ medium. (niscair.res.in)

Chalcone molecules deserve the credit of being potential anti-diabetic candidates that act by modulating the therapeutic targets Peroxisome proliferator-activated receptor gamma (PPAR-Γ), Dipeptidyl peptidase-4 (DPP-4), α-glucosidase, Protein-tyrosine Phosphatase 1B (PTP1B), aldose reductase, and tissue sensitivity. (wikipedia.org)
Here, by functional and biological analysis of the most representative molecules of an in house library of natural products, we have designed and synthetized the chalcone-derivative 8 possessing Notch inhibitory activity at low micro molar concentration in T-ALL cell lines. (sigmaaldrich.com)
Herein, we report the synthesis, structures, and characterization of a series of five chalcone derivatives, obtained by carefully modifying the structure with various para and meta substitutents, expecting new molecules with high second-order optical nonlinearities. (scirp.org)
Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. (eurekaselect.com)
Chern, C.Y. (2013), "Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model", Molecules, (18), 2052-2060. (pharmatutor.org)
Tran, T.D. (2016), "Synthesis and Selective Cytotoxic Activities on Rhabdomyosarcoma and Noncancerous Cells of Some Heterocyclic Chalcones", Molecules, (21), 1-10. (pharmatutor.org)
Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. (biomedcentral.com)

Chalcone is a fragrant ketone that frames a focal center for an assortment of significant organic mixes, which are altogether known as chalcones. (alliedacademies.org)

Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. (springer.com)
It was found that methoxy and hydroyl substituted chalcone semicarbazones were potent free radical scavenger and unsubstituted compound showed very less activity. (tsijournals.com)
trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. (medchemexpress.com)

Other key ingredients include hesperidin methyl chalcone to promote stronger blood vessel walls, and dextra sulfate to help reduce the appearance of swelling. (thefreedictionary.com)
Hesperidin Methyl Chalcone from Douglas Laboratories supports circulation health. (swansonvitamins.com)
Each serving delivers 500 mg of hesperidin methyl chalcone. (swansonvitamins.com)

The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. (mdpi.com)

The nature and position of the chalcone substituents had major effects on inhibitory activity as well as selectivity for AChE over BChE. (springer.com)
Hence, the inhibitory activity of structurally related prenylated and non-prenylated chalcones on activated human hepatic stellate cells was investigated. (uni-regensburg.de)

Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. (uniprot.org)
2008a) isolated five flavanones and three chalcones from C. (thefreedictionary.com)
Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, antiangiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. (eurekaselect.com)
HPLC of flavanones and chalcones in different species and clones of Salix. (semanticscholar.org)

In the present study a series of chalcone semicarbazones was synthesized and evaluated for antioxidant activity by DPPH free radical scavenging assay. (tsijournals.com)

This review highlights the effects of chalcone derivatives in different types of immune cells. (dovepress.com)

Anthocyanins, which accumulate in leaves and stems in response to low temperature and changes in light intensity, are synthesized through the phenylpropanoid pathway that is controlled by key enzymes that include phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS). (plantphysiol.org)

Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. (sigmaaldrich.com)
trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM [2] . (medchemexpress.com)

Chalcone and four chalcone analogues 1a - d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. (mdpi.com)
Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos. (mdpi.com)
Chen, Y.-H. Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model. (mdpi.com)
Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential - Descarga este documento en PDF. (duhnnae.com)

Next, chalcone derivatives were synthesized and assayed for their antimicrobial activity against several bacterial strains in combination with penicillin antibiotics. (thefreedictionary.com)

Several chalcones showed in vitro antibacterial activity against Gram-bacterial. (deepdyve.com)
Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides. (currentorganicsynthesis.com)
Materials and Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated. (currentorganicsynthesis.com)
In the current study, an efficient synthesis of new triazole-linked chalcone 3 a-g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. (elsevier.com)

Transgenic Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone synthase activity and purple flower pigment through posttranscriptional chsA RNA degradation. (nih.gov)
We show that CHIL2 is part of an active DMX biosynthetic metabolon in hop glandular trichomes that encompasses a chalcone synthase (CHS) and a membrane-bound prenyltransferase, and that type IV CHI-fold proteins of representative land plants contain conserved function to bind with CHS and enhance its activity. (pnas.org)
Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer's disease. (springer.com)
Kahrović E, Zahirović A, Višnjevac A, Osmanković I, Turkušić E, Kurtagić H. Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like Activity. (srce.hr)
Kinetic measurements revealed that the binuclear (chalcone-containing) complexes have enhanced catalytic activity as compared to the mononuclear Cu(II) flavonol complexes. (srce.hr)
Structure-activity relationships were afforded for the chalcone scaffold. (sigmaaldrich.com)
We here highlight the unique relationship between pharmacokinetics and anti-asthmatic activity of chalcone 4, a CXCL12 neutraligand. (ersjournals.com)
Molecular modeling methods performed on forty-three ionone based chalcones derivatives as anti-prostate cancer activity. (ijpsonline.com)
Present study deals with comparative molecular field analysis, comparative similarity indices analysis and hologram quantitative structure activity relationship and molecular docking studies of the ionone-based chalcones and their derivatives, obtained from literature. (ijpsonline.com)
These reactive α,β-unsatutated keto function in chalcones are responsible for their biological activity. (pharmatutor.org)
In order to gain further insights into the structural requirements for anti-tuberculosis activity by chalcone derivatives of 1,3-diphenylprop-2-ene-1-one, quantitative structure activity relationship (QSAR) was performed using genetic function approximation (GFA). (oalib.com)
The highest scavenger activity observed in compound 23 is probably due to the presence of hydroxyl group in the acetophenic moiety and methoxy group in aldehydic moiety of the chalcone. (tsijournals.com)
Recent insights into the mechanism of epoxide hydrolase activity are combined with these experimental results to support a proposed mechanism of sEH inhibition by chalcone oxides. (elsevier.com)
Cytotoxic Activity of Chalcones Isolated from Lonchocarpus Sericeus (Pocr. (semanticscholar.org)
Three chalcone derivatives with amine groups (4a-c) were synthesized and evaluated for their antimalarial activity.Three aminoalkylated chalcone derivatives (4a-c) have been prepared through Claisen-Schmidt condensation reactionfrom vanillin and chloroacetophenone, followed by the Mannich reaction to add amine group. (who.int)
The addition of morpholine (4a), piperidine (4b), and diethylamine (4c) as amine groups significantlycould improve the antimalarial activity with IC50 of 0.62, 0.54, and 1.12 µM, respectively (strong activity), comparedwith the chalcone without amine group (3) with IC50 of 25.84 µM (moderate activity). (who.int)
Some of the chalcones have exhibited moderate activity. (bvsalud.org)

Methyl on the aromatic ring of chalcones was brominated by NBS, and then the resulting mixture was reacted with imidazole to get the target compound. (deepdyve.com)
Antidepressant-like Effect of a Chalcone Compound, DHIPC and Its Possible Mechanism', Iranian Journal of Pharmaceutical Research , 17(1), pp. 193-201. (ac.ir)
DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalcone compound. (ac.ir)
RESULTS: Several related chalcones, acyl hydrazides, and amides killed cultured bloodstream forms of T. b. brucei, with the most effective compound reducing parasite numbers by 50% relative to control populations at a concentration of 240 nM. (ox.ac.uk)
In the compound came from N-(4-acetylphenyl) benzenesulfonamide and benzaldehyde, there is a rotation of ca. 180° on the bond axis bridging the sulfonamide and chalcone motifs of one conformer if the two others are taken as references. (ufg.br)

The chalcone derivatives were evaluated for in vitro antibacterial, antifungal, antioxidant activities. (ajol.info)
Antifungal and antibacterial chalcones from Myrica serrata. (semanticscholar.org)

Silybin content and overexpression of chalcone synthase genes in Silybum marianum L. plants under abiotic elicitation. (must.edu.eg)

Herein, we report the synthesis and structural elucidation of a novel sulfonamide chalcone 2,5-dichloro- N -{3-[(2 E )-3-(4-nitrophenyl)prop-2-enoyl]phenyl}benzenesulfonamide (BSC) by Single Crystal X-ray Diffraction and spectroscopy analysis (Infrared, NMR and Mass Spectroscopy). (rsc.org)
Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. (ufg.br)

A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. (ebi.ac.uk)
Five 1,3-diarylprop-2-en-1-ones 3a-e are synthesized by Claisen-Schmidt condensation of aryl methyl ketones and 4-chlorobenzaldehyde to give pyrazolines 5a-e by cyclization with phenylhydrazine in gl. (niscair.res.in)
4-hydroxy-3-acetylcoumarin and 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one have been used as starting materials and were condensed with indole aldehyde, pyrrole aldehydes independently to give the corresponding chalcones. (eurekaselect.com)
3-Acetyl-4-hydroxy-2H-chromen-2-one, 3-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one, indoles, pyrroles, chalcones, alkylation. (eurekaselect.com)
The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. (bioseek.eu)

Genome-wide analysis of the chalcone synthase superfamily genes of Physcomitrella patens Koduri, P. (deepdyve.com)

Flavokawain A (FKA), a major chalcone from kava extract, has been reported to have antitumor effects on multiple cancer cell lines. (aacrjournals.org)
AshiGuard is a whole food supplement that contains standardized ashitaba chalcone extract. (dyna-nutrition.com)

Chalcones can be prepared by an aldol condensation between benzaldehyde and acetophenone in the presence of sodium hydroxide as a catalyst. (wikipedia.org)
In a study investigating green syntheses, chalcones were synthesized from the same starting materials in high-temperature water (200 to 350 °C). Substituted chalcones were also synthesised by piperidine-mediated condensation to avoid side reactions such as multiple condensations, polymerizations, and rearrangements. (wikipedia.org)
Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. (hindawi.com)
Chalcones 28 ~ 32 were prepared by using aldol condensation of appropriate substituted benzaldehydes 23 ~ 27 , 33 , 34 , and acetyl phenols in KOH/EtOH and deprotection reaction. (hindawi.com)
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. (scirp.org)
The five derivatives of chalcone substituted with donor-acceptor substituents ( Table 1 ) were prepared by Claisen-Schmidt condensation reaction [8] (Scheme 1). (scirp.org)
Twelve new chalcones were synthesized by claisen-schmidid condensation and studies for their toxicity to fish. (bvsalud.org)

To date, no report on molecular modeling has been established on ionone based chalcones for anti-prostate cancer. (ijpsonline.com)
Molecular docking was used in order to theoretically investigate the interactions of the chalcones with ␣-tubulin mainly focusing on binding modes, potential interactions and specific binding sites. (dissertations.se)
The chalcone molecular backbones are featured by different levels of planarity in their conformers. (ufg.br)

Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids ( 5d - 7j , 9d - 11f , 12k - 13m ) against AChE and BChE. (springer.com)

MATERIALS AND METHODS: Chalcone and acyl hydrazide derivatives are known to retard the growth of Plasmodium falciparum in vitro and inhibit the malarial cysteine proteinase, falcipain. (ox.ac.uk)

See the reference protein sequence for chalcone synthase (NP_001304585.2). (nih.gov)

A suitable mechanism involving the chalcone molecule and the reactive species of TCICA in the rate determining step has also been proposed. (niscair.res.in)

Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. (spandidos-publications.com)
Prenylated chalcone xanthohumol assoc. (ugent.be)
Wyns C, Van Steendam K, Vanhoecke B, Deforce D, Bracke M, Heyerick A. Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal antibody. (ugent.be)
The minor hop ( Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. (bioseek.eu)

One of well-established biological activities for chalcone derivatives is as acetylcholinesterase inhibitors, which can be developed for the therapy of Alzheimer's disease. (e-jurnal.com)

The chalcones are flavokawain A, B, and C that constitute up to 0.46%, 0.015%, and 0.012% of kava extracts, respectively ( 12 ). (aacrjournals.org)
Flavokawain A (FKA) is the predominant chalcone identified from the kava plant. (aacrjournals.org)
We have shown that flavokawain B (FKB), a kava chalcone, is about 4- to 12-fold more effective in reducing the cell viabilities of androgen receptor (AR)-negative, HRPC cell lines DU145 and PC-3 than AR-positive, hormone-sensitive prostate cancer cell lines LAPC4 and LNCaP, with minimal effect on normal prostatic epithelial and stromal cells. (hawaii-agriculture.com)
Aim: To examine the effects of flavokawain B (FKB), a novel kava chalcone, on the growth of uterine leiomyosarcoma (LMS) cells and investigated its utility in the treatment of uterine LMS. (elsevier.com)

Results: Chalcones and their pyrazoline derivatives were synthesized and characterised by 1HNMR, 13C-NMR, Mass spectrometry and FTIR. (lettersindrugdesigndiscovery.com)
Conclusion: Chalcone and their pyrazoline derivatives were synthesized and screened for their anti-Alzheimer and antioxidant potential. (lettersindrugdesigndiscovery.com)

Although chalcones occur naturally, they could be available in larger amounts through an efficient and simple synthesis. (biomedcentral.com)

Anatomy7

Organisms24

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes32

Disciplines and Occupations1

Technology, Industry, Agriculture6

Information Science4

Health Care1

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (1/163)

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (2/163)

Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages. (3/163)

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. (4/163)

Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. (5/163)

2'-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha- and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells. (6/163)

Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L. (7/163)

Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions. (8/163)

Chalcones

Acyltransferases

Intramolecular Lyases

Propiophenones

Kava

Phenylalanine Ammonia-Lyase

Flavanones

Anthocyanins

Morus

Humulus

Flavonoids

Angelica

Zingiberaceae

Plants

Pterocarpans

Tetrathionic Acid

Mercuribenzoates

Flavonols

Photofluorography

Genes, Plant

Phloroglucinol

Elaeagnaceae

Pigmentation

Plant Proteins

Plants, Medicinal

Medicago sativa

Chalcone

Soybeans

Mallotus Plant

Rosales

Trans-Cinnamate 4-Monooxygenase

Butanones

Fabaceae

Molecular Sequence Data

Ammonia-Lyases

Gene Expression Regulation, Plant

Alpinia

Apiaceae

Viola

Helichrysum

Isomerases

Propane

Coumaric Acids

Flowers

Agaricales

Flavones

Asteraceae

Plant Extracts

Molecular Structure

Phenylpropionates

DNA, Plant

Gefarnate

Quercetin

Arabidopsis

Base Sequence

Plants, Genetically Modified

Pyrones

Amino Acid Sequence

Alcohol Oxidoreductases

Cloning, Molecular

Thiosulfates

Inhibitory Concentration 50

RNA, Plant

Seeds

Gene Expression Regulation, Enzymologic

Lycopersicon esculentum

Structure-Activity Relationship

Biosynthetic Pathways

Multigene Family

Isoflavones

Stilbenes

Light

Plant Roots

Enzyme Induction

Monophenol Monooxygenase

Melanins

Catalysis

Mixed Function Oxygenases

Immunochemistry

Fungi