Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.Trypanosoma cruzi: The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.Asymptomatic Diseases: Diseases that do not exhibit symptoms.Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Cardiomyopathy, Hypertrophic: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).BrazilCardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Cardiomyopathy, Restrictive: A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.Takotsubo Cardiomyopathy: A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.Consent Forms: Documents describing a medical treatment or research project, including proposed procedures, risks, and alternatives, that are to be signed by an individual, or the individual's proxy, to indicate his/her understanding of the document and a willingness to undergo the treatment or to participate in the research.Fatty Acids, Omega-3: A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.Tropical Medicine: The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Heart: The hollow, muscular organ that maintains the circulation of the blood.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Diagnostic Tests, Routine: Diagnostic procedures, such as laboratory tests and x-rays, routinely performed on all individuals or specified categories of individuals in a specified situation, e.g., patients being admitted to the hospital. These include routine tests administered to neonates.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Myocarditis: Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.Trypanocidal Agents: Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.Molecular Mimicry: The structure of one molecule that imitates or simulates the structure of a different molecule.Autoimmunity: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.Cardiac Electrophysiology: The study of the electrical activity and characteristics of the HEART; MYOCARDIUM; and CARDIOMYOCYTES.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Endemic Diseases: The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)Sick Sinus Syndrome: A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.Atrioventricular Block: Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.Signal Processing, Computer-Assisted: Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Rheumatic Fever: A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.BooksRheumatic Heart Disease: Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM.Pelvic Inflammatory Disease: A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.Allied Health Occupations: Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.Chemokine CCL2: A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.Polymorphism, Restriction Fragment Length: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.Aggregatibacter: A genus of PASTEURELLACEAE. Members are nonmotile, Gram-negative, facultatively anaerobic rods or coccobacilli. Its members are X factor (HEMIN) independent and variably dependent on V factor (NAD).Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Antiprotozoal Agents: Substances that are destructive to protozoans.Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.Trypanosomiasis: Infection with protozoa of the genus TRYPANOSOMA.Cardiology: The study of the heart, its physiology, and its functions.BelgiumElectronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Spinal Fractures: Broken bones in the vertebral column.Genetic Research: Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.

Alterations in cardiac beta-adrenergic receptors in chagasic mice and their association with circulating beta-adrenoceptor-related autoantibodies. (1/382)

OBJECTIVE: Cardiac tissue from chagasic mice was studied to evaluate the expression and biological activity of beta-adrenoceptors in association with circulating beta-adrenoceptor-related autoantibodies. METHODS: BALB/c inbred mice that were either treated or not treated with atenolol (2.5 mg/kg) and infected or not infected with 1 x 10(4) trypomastigotes (CA-1 strain) were sacrificed weekly up to week nine. Morphological, binding and contractility studies were performed on the four different groups of animals. The effect of their serum antibodies was also assayed in binding and contractility studies on normal heart preparations. RESULTS: Hearts from chagasic myocarditis mice showed a beta-adrenoceptor-related dysfunction, with a decrease in heart contractility, impaired response to exogenous beta-adrenoceptor agonist and a significant reduction in beta-adrenergic binding sites. Those effects were maximum at eight-nine weeks post-infection and were improved by treating infected mice with atenolol. In addition, serum or IgG from chagasic myocarditis mice was capable of interacting with cardiac beta-adrenoceptors, reducing the number of binding sites and inhibiting the contractile response to exogenous norepinephrine. IgG effects that were observed in normal myocardium, were highest in sera from mice eight-nine weeks post-infection and correlate with the degree of myocarditis. Moreover, chagasic autoantibodies from infected mice recognized a peptide corresponding to the sequence of the second extracellular loop of the human beta 1-adrenoceptor. CONCLUSIONS: (1) The development of alterations in beta-adrenergic receptors, related to cardiac dysfunction, may be associated with the presence of circulating antibodies against these receptors and (2) it is possible that the chronic deposits of these autoantibodies in cardiac beta-adrenoceptors could lead to a progressive blockade with sympathetic denervation, a phenomenon that has been described in the course of chagasic myocarditis.  (+info)

Myocardial parasite persistence in chronic chagasic patients. (2/382)

The persistence of Trypanosoma cruzi tissue forms was detected in the myocardium of seropositive individuals clinically diagnosed as chronic chagasic patients following endomyocardial biopsies (EMBs) processed by immunohistochemical (peroxidase-anti-peroxidase [PAP] staining) and molecular (polymerase chain reaction [PCR]) techniques. An indirect immunofluorescent technique revealed antigenic deposits in the cardiac tissue in 24 (88.9%) of 27 patients. Persistent T. cruzi amastigotes were detected by PAP staining in the myocardium of 22 (84.6%) of 26 patients. This finding was confirmed with a PCR assay specific for T. cruzi in 21 (91.3%) of 23 biopsy specimens from the same patients. Statistical analysis revealed substantial agreement between PCR and PAP techniques (k = 0.68) and the PCR and any serologic test (k = 0.77). The histopathologic study of EMB specimens from these patients revealed necrosis, inflammatory infiltrates, and fibrosis, and made it possible to detect heart abnormalities not detected by electrocardiogram and/or cineventriculogram. These indications of myocarditis were supported by the detection of T. cruzi amastigotes by the PAP technique or its genome by PCR. They suggest that although the number of parasites is low in patients with chronic Chagas' disease, their potential for heart damage may be comparable with those present during the acute phase. The urgent necessity for testing new drugs with long-term effects on T. cruzi is discussed in the context of the present results.  (+info)

Parasite persistence correlates with disease severity and localization in chronic Chagas' disease. (3/382)

The protozoan parasite Trypanosoma cruzi infects up to 20 million people in Latin America, and the resulting disease (Chagas' disease) is a leading cause of heart disease and death in young adults in areas endemic for the parasite. The clinical symptoms of Chagas' disease have been attributed to autoimmune reactivity to antigens shared by the parasite and host muscle or neuronal tissue. In the present study, in situ polymerase chain reaction analysis was used in murine models of Chagas' disease to demonstrate an absolute correlation between the persistence of parasites and the presence of disease in muscle tissue. Clearance of parasites from tissues, presumably by immunologic mechanisms, correlated with the abatement of inflammatory responses and the resolution of disease. These data provide strong evidence for parasite persistence as a primary cause of Chagas' disease and argue for efforts to eliminate T. cruzi from the host as a means for prevention and treatment of Chagas' disease.  (+info)

Cardiac M(2) muscarinic cholinoceptor activation by human chagasic autoantibodies: association with bradycardia. (4/382)

OBJECTIVE: To assess whether exposure of cardiac muscarinic acetylcholine receptors (mAChR) to activating chagasic antimyocardial immunoglobulins results in bradycardia and other dysautonomic symptoms associated with the regulation of heart rate. METHODS: Trypanosoma cruzi infected patients with bradycardia and other abnormalities in tests of the autonomic nervous system were studied and compared with normal subjects. Antipeptide antibodies in serum were demonstrated by an enzyme linked immunosorbent assay using a synthetic 24-mer-peptide corresponding antigenically to the second extracellular loop of the human heart M(2) mAChR. The functional effect of affinity purified antipeptide IgG from chagasic patients on spontaneous beating frequency and cAMP production of isolated normal rat atria was studied. RESULTS: There was a strong association between the finding of antipeptide antibodies in chagasic patients and the presence of basal bradycardia and an altered Valsalva manoeuvre (basal bradycardia: chi(2) = 37.5, p < 0. 00001; Valsalva manoeuvre: chi(2) = 70.0, p < 0.00001). The antipeptide autoantibodies also showed agonist activity, decreasing the rate of contraction and cAMP production. The effects on rat atria resembled the effects of the authentic agonist and those of the total polyclonal chagasic IgG, being selectively blunted by atropine and AF-DX 116, and neutralised by the synthetic peptide corresponding in amino acid sequence to the second extracellular loop of the human M(2) mAChR. CONCLUSIONS: There is an association between circulating antipeptide autoantibodies in chagasic patients and the presence of bradycardia and other dysautonomic symptoms. Thus these autoantibodies are a marker of autoimmune cardiac autonomic dysfunction. The results support the hypothesis that autoimmune mechanisms play a role in the pathogenesis of chagasic cardioneuromyopathy.  (+info)

Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas' disease: a three dimensional confocal microscopy study. (5/382)

OBJECTIVE: To analyse the morphological aspects of the extracellular matrix and microcirculation to clarify whether chronic Chagas' cardiopathy (CCC) is an accurate model to study the pathogenesis of idiopathic dilated cardiomyopathy (IDCM). DESIGN: Thick histological myocardial sections were prepared to analyse collagen, and microcirculation was examined during confocal laser and light microscopy. SETTING: The specimens were prepared at the pathology service of the Heart Institute of Sao Paulo, Brazil. PATIENTS: Nine control hearts, eight IDCM hearts, and 10 CCC hearts were studied after necropsy. MAIN OUTCOME MEASURES: The number of collagen struts per 100x field, the area of fibrosis (%), and the diameters of arterioles and capillaries were measured in each heart to establish outcome. RESULTS: A smaller number (mean (SD)) of collagen struts was seen in the hearts in the IDCM group (9.1 (4.1)) than in the control (22.4 (3.2)) (p < 0.05) or CCC (15.7 (7.4)) (p > 0.05) groups. Fibrosis was greater in the CCC hearts (13.8 (10.5)%) than in the IDCM hearts (5.9 (6.6)%) (p > 0.05). Major increases in arteriole (65.4 (9.9) microm) and capillary (9.9 (1.7) microm) diameters were seen in the CCC hearts but not in the IDCM hearts (arteriole diameter 40.3 (7.9) microm; capillary diameter 7.9 (1.3) microm). CONCLUSIONS: Hearts demonstrating CCC and IDCM present different extracellular and microvessel alterations. This suggests that distinct pathogenic mechanisms are responsible for each condition and that CCC is not an effective model to study IDCM.  (+info)

Application of cardiac gated magnetic resonance imaging in murine Chagas' disease. (6/382)

To evaluate the role of gated cardiac magnetic imaging resonance (MRI) in Chagas' disease, we infected mice with Trypanosoma cruzi (Brazil strain). Two models were chosen for study, the CD1 and the inducible nitric oxide synthase knockout (NOS2-/-) mice. Infection of CD1 mice was associated with a significant increase in the right ventricular inner diameter (RVID) that was reversed in some mice by verapamil. Expression of cardiac NOS2 has been associated with myocardial dysfunction. Therefore, we evaluated chagasic cardiomyopathy in NOS2-/- and syngeneic wild type (WT) mice. Infected WT mice exhibited an increase in RVID in the acute phase (< 60 days postinfection) that was more marked during chronic infection (>100 days postinfection). Chronically infected NOS2-/- mice had an increase in RVID. The RVID in infected WT mice was greater than in NOS2-/- mice. These data demonstrate that MRI is a useful tool in the serial evaluation of the heart in murine Chagas' disease. In addition, it supports the notion that the NOS2-/-/NO pathway may contribute to the pathogenesis of murine chagasic cardiomyopathy.  (+info)

Chronic Chagas' heart disease in a Japanese-Brazilian traveler. A case report. (7/382)

A 57-year-old Japanese-Brazilian man, visiting Japan for only 9 days, was admitted to our hospital due to syncope and frequent ventricular premature beats. He grew up in a rural area of Brazil and moved to Sao Paulo in 1959 when he was 20 years old. We suspected chronic Chagas' heart disease, i.e., dilated cardiomyopathy with apical ventricular aneurysm, right bundle branch block with left anterior fascicular block, and various arrhythmias including supraventricular premature beats, ventricular premature beats and non-sustained ventricular tachycardia because he showed typical echo- and electrocardiographic features of the disease. Coronary arteriograms were normal, and left ventriculogram confirmed the existence of apical ventricular aneurysm. A left ventricle biopsy specimen showed hypertrophic cardiac muscle with mild fibrosis. The diagnosis of chronic Chagas' disease was finally confirmed by the demonstration of Trypanosoma cruzi itself in the blood as well as Trypanosoma cruzi antibodies.  (+info)

Immunopathology of Chagas disease. (8/382)

The main clinical forms of Chagas disease (acute, indeterminate and chronic cardiac) present strong evidences for the participation of the immune system on pathogenesis. Although parasite multiplication is evident during acute infection, the intense acute myocarditis of this phase exhibits clear ultrastructural signs of cell-mediated immune damage, inflicted to parasitized and non-parasitized myocardiocytes and to the endothelium of myocardial capillaries (microangiopathy). Inflammation subsides almost completely when immunity decreases parasite load and suppressor factors modulate host reaction, but inflammation does not disappear when the disease enters the indeterminate phase. Inflammation becomes mild and focal and undergoes cyclic changes leading to complete resolution. However, the process is maintained because the disappearance of old focal lesions is balanced by the upsurge of new ones. This equilibrium allows for prolonged host survival in the absence of symptoms or signs of disease. The chronic cardiac form is represented by a delayed-type, cell-mediated diffuse myocarditis, that probably ensues when the suppressive mechanisms, operative during the indeterminate phase, become defaulted. The mechanism responsible for the transition from the indeterminate to the cardiac form, is poorly understood.  (+info)

Several studies have shown the beneficial effects of polyunsaturated fatty acids on inflammatory processes, dyslipidemia, and cardiovascular diseases, there are no reports about food intake and PUFA supplementation in chronic Chagas cardiomyopathy patients. Thus, the objective of this study is to assess the effects of omega-3 PUFA supplementation on the lipid profile and the pro-inflammatory and anti-inflammatory cytokine profiles in chronic Chagas cardiomyopathy patients.. After patients are selected by cardiologists, they will be seen by study nutritionists, who will explain the study procedures to the patients and administer the free and informed consent form. The patients who agree to participate in the study will sign the consent form and undergo the initial assessment.. The following data will be collected and evaluated in the study: sociodemographic data (age, sex, ethnicity/race, education, and domicile), clinical data (functional class and vital signs), alcoholism, smoking, prescription ...
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects 7 million people in Latin American areas of endemicity. About 30% of infected patients will develop chronic Chagas cardiomyopathy (CCC), an inflammatory cardiomyopathy characterized by hypertrophy, fibrosis, and myocarditis. Further studies are necessary to understand the molecular mechanisms of disease progression. Transcriptome analysis has been increasingly used to identify molecular changes associated with disease outcomes. We thus assessed the whole-blood transcriptome of patients with Chagas disease. Microarray analysis was performed on blood samples from 150 subjects, of whom 30 were uninfected control patients and 120 had Chagas disease (1 group had asymptomatic disease, and 2 groups had CCC with either a preserved or reduced left ventricular ejection fraction [LVEF]). Each Chagas disease group displayed distinct gene expression and functional pathway profiles. The most different expression patterns were between ...
Abstract. Approximately 8 million people have Trypanosoma cruzi infection, and nearly 30% will manifest Chagas cardiomyopathy (CC). Identification of reliable early indicators of CC risk would enable prioritization of treatment to those with the highest probability of future disease. Serum markers and electrocardiogram (EKG) changes were measured in 68 T. cruzi-infected individuals in various stages of cardiac disease and 17 individuals without T. cruzi infection or cardiac disease. T. cruzi-infected individuals were assigned to stage A (normal EKG/chest x-ray [CXR]), B (abnormal EKG/normal CXR), or C (abnormal EKG/cardiac structural changes). Ten serum markers were measured using enzyme-linked immunosorbent assay (ELISA)/Luminex, and QRS scores were calculated. Higher concentrations of transforming growth factor-β1 (TGFβ1), and TGFβ2 were associated with stage B compared with stage A. Matrix Metalloproteinase 2 (MMP2), Tissue Inhibitors of MMP 1, QRS score, and Brain Natriuretic Protein rose
Diagnostic Tests for Chagas Cardiomyopathy including blood tests, urine tests, swabs, diagnostic tests, lab tests, and pathology testing.
Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. It is a disease for which effective treatment in its advanced clinical forms is lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation is effective in reducing inflammation and fibrosis in the mouse model of Chagas disease. The present study used magnetic resonance un-aging to assess changes in the cardiac morphology of infected mice after therapy with BMCs. Serial imaging of the BMC-treated mice revealed regression of the right ventricular dilatation typically observed in the chagasic mouse model ...
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential causative factor for arrhythmias and contractile dysfunction. Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. We chose a model that resembles B1-B2 stage of human CCC, treated mice with resveratrol and performed electrocardiography and echocardiography studies. Resveratrol reduced the prolonged PR and QTc intervals, increased heart rates and reversed sinus arrhythmia, atrial and atrioventricular conduction disorders; restored a normal left ventricular ejection fraction, improved stroke volume and cardiac output. Resveratrol activated the AMPK-pathway and reduced both ROS production and heart parasite burden, without interfering with vascularization or myocarditis ...
Several induced cardiomyopathy , Mycoplasma pneumonia-induced myocarditis, heart damage investigations have shown positive effects of Se on experimental models: cardiotoxicity induced by chemotherapics, ischemic cardiopathy, CVB3 and LP-BM5 (murine AIDS, retrovirus)-in reperfused heart, and in chagasic cardiopathy. In addition, beneficial effects of Se supplementation were reported in patients with myocardial infarct, Keshan disease, and cardiac dysfunction during HPN.. Our group has investigated the role and Se effect on infection by T. cruzi. By evaluating plasma Se levels in 170 chagasic patients, we discovered that the frequency of subjects with Se levels lower than normal was significantly higher in those with severe cardiopathy. Moreover, in this pioneering research, we found a positive correlation between Se levels and the LVEF, indicating that normal Se levels pave the way for efficient cardiac function. Later, we investigated if nutritional deficiency of this trace element interfered ...
Chagas disease remains a significant public health issue in many countries and is a major cause of morbidity and mortality in Latin America. The social impact of this disease can be evaluated by the estimated human infection prevalence of 16 million people (1) in this region. Chronic Chagas heart disease is certainly the most important clinical form of Chagas disease. Chronic cardiac involvement is more prevalent and is also associated with grater morbidity and mortality when compared to the digestive form (2,3). In the natural history of the disease, the progression of cardiac involvement is heterogeneous and tends to be slow: about 70% of cardiac patients who have mild cardiac involvement, without heart failure, remain clinically stable for periods ranging from 12 to 27 years of follow-up (4). The majority of patients with Chagas disease remain in the indeterminate form of the disease for 10-30 years or even more. They have positive serology, no symptoms or signs of Chagas disease, and ...
... Annu Rev Pathol. 2018 Oct 24;: Authors: Bonney KM, Luthringer DJ, Kim SA, Garg NJ, Engman DM Abstract Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T. cruzi is transmitted to people is through contact w...
REFERENCES. 1. Traina MI, Hernandez S, Sanchez DR, Dufani J, Salih M, Abuhamidah AM, et al. Prevalence of Chagas Disease in a U.S. Population of Latin American Immigrants with Conduction Abnormalities on Electrocardiogram. PLoS Negl Trop Dis. 2017;11(1):e0005244. DOI: 10.1371/journal.pntd.0005244. [ Links ]. 2. World Health Organization. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Wkly Epidemiol Rec. 2015;90(6):33-43. PMID: 25671846 [ Links ]. 3. Pérez-Molina JA, Molina I. Chagas disease. Lancet. 2018;391(10115):82-94. DOI: 10.1016/S0140-6736(17)31612-4. [ Links ]. 4. Rocha MO, Ribeiro AL, Teixeira MM. Clinical management of chronic Chagas cardiomyopathy. Front Biosci. 2003;8:e44-54. PMID: 12456332. [ Links ]. 5. Rassi A Jr, Rassi SG, Rassi A. Sudden death in Chagas disease. Arq Bras Cardiol. 2001;76 (1):75-96. PMID: 11175486. [ Links ]. 6. Bern C, Montgomery SP, Herwaldt BL, Rassi A Jr, Marin-Neto JA, Dantas RO, et al. Evaluation and treatment of Chagas ...
Author Summary Trypanosoma cruzi is a protozoan parasite responsible for Chagas disease. Chronic Chagas heart disease (cChHD) is not only the most frequent and severe consequence of the chronic infection by T. cruzi, but is also the main cause of cardiomyopathy in South and Central America. Patients with cChHD possess high levels of antibodies against the carboxyl-terminal tail of the ribosomal P proteins of T. cruzi (called the R13 epitope). These antibodies, as well as the murine monoclonal antibody (mAb) 17.2, are able to cross-react with, and stimulate, the ß1 adrenergic receptor (ß1-AR). Indeed, the mAb 17.2 was able to specifically detect human β1-AR and induce some of the classical cardiac symptoms after passive transfer to mice. To study the structural basis of this cross-reactivity, we determined the crystal structure of the Fab region of the mAb 17.2 alone and in complex with R13. Additionally, we generated a model of human β1-AR to elucidate the interaction with anti-R13 antibodies in
In a rodent model of chronic ChHD, the administration of carvedilol did not change ventricular remodeling and function or interstitial and perivascular fibrosis; additionally, total mortality was unchanged, even though early mortality (up to 100 days with infection) was reduced with carvedilol (62). However, carvedilol was effective in attenuating oxidative damage in ChHD patients after 6 months of treatment in a prospective, case-control, nonrandomized, open-label study (63). Also, a study with 9 patients with ChHD-HF tested the effects of metoprolol (titrated up to 25 mg) and found improvement in functional status, increase in LVEF, and reduction in LV end-diastolic diameter (64). Retrospective analyses have suggested a beneficial effect of β-blockers in patients with ChHD-HF. In a cohort of 231 consecutive patients with ChHD-HF, β-blocker therapy had a protective effect (65). A retrospective analysis of the REMADHE trial (A Long-Term Prospective Randomized Controlled Study Using Repetitive ...
TY - JOUR. T1 - Increased oxidative stress contributes to cardiomyocyte dysfunction and death in patients with Fabry disease cardiomyopathy. AU - Chimenti, Cristina. AU - Scopelliti, Fernanda. AU - Vulpis, Elisabetta. AU - Tafani, Marco. AU - Villanova, Lidia. AU - Verardo, Romina. AU - De Paulis, Ruggero. AU - Russo, Matteo A.. AU - Frustaci, Andrea. PY - 2015/11/1. Y1 - 2015/11/1. N2 - Cardiac dysfunction of Fabry disease (FD) has been associated with myofilament damage and cell death as result of α-galactosidase A deficiency and globotriaosylceramide accumulation. We sought to evaluate the role of oxidative stress in FD cardiomyocyte dysfunction. Myocardial tissue from 18 patients with FD was investigated for the expression of inducible nitric oxide synthase (iNOS) and nitrotyrosine by immunohistochemistry. Western blot analysis for nitrotyrosine was also performed. Oxidative damage to DNA was investigated by immunostaining for 8-hydroxydeoxyguanosine (8-OHdG), whereas apoptosis was ...
Figure 6: Inferoseptal thinning (left panel) of the left ventricular myocardium and LGE (right panel) in the inferior, inferoseptal, and anteroseptal segments (arrows). Perspective:. LGE is correlated with inducible ventricular tachycardia and sudden death in many myocardial diseases, such as ischemic, hypertrophic, dilated, or arrhythmogenic right ventricular cardiomyopathy as well as in chronic Chagas heart disease [2]. The presence and the extent of LGE is also associated with recurrent tachyarrhythmia and even sudden cardiac arrest [3]. New onset left bundle branch block has been described in patients with myocarditis [4].. We report a case of acute lymphocytic myocarditis with a pattern of LGE correlating with conduction disturbances such as total AV Block, and with ventricular arrhythmia. This case illustrates the ability of CMR to demonstrate the acute changes occurring during myocarditis and by using LGE to show the substrate of electrophysiological disturbances caused by myocardial ...
Figure 6: Inferoseptal thinning (left panel) and LGE (right panel) of the left ventricular myocardium (arrows). Perspective:. LGE is correlated with inducible ventricular tachycardia and sudden death in many myocardial diseases, such as ischemic, hypertrophic, dilated, or arrhythmogenic right ventricular cardiomyopathy as well as in chronic Chagas heart disease (Mavrogeni 2013). The presence and the extent of LGE is also associated with recurrent tachyarrhythmia and even sudden cardiac arrest (Neilan 2015). New onset left bundle branch block has been described in patients with myocarditis (Mavrogeni 2014).. We report a case of acute lymphocytic myocarditis with a pattern of LGE correlating with conduction disturbances such as total AV Block, and with ventricular arrhythmia. This case illustrates the occurrence of right bundle branch block, left anterior hemi-block, and even transient complete atrioventricular block in myocardial inflammation and its visibility by CMR.. This case proves that CMR ...
Background. Only a subset of individuals infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC). Familial aggregation of CCC in areas of endemicity indicates that susceptibility may be genetic, which may be a plausible explanation for why only one-third of T. cruzi-infected individuals develop CCC. The monocyte chemoattractant protein-1 (CCL2/MCP-1) has been shown to enhance the uptake of T. cruzi in murine macrophages and to up-regulate the inducible nitric oxide synthase/nitic oxide system, with a consequent increased production of nitric oxide that controls the replication of the parasite.. Methods. We assessed CCL2 variants at position -2518A/G, which are known to influence transcriptional activity, by polymerase chain reaction and restriction fragment-length polymorphism in 245 individuals, all of whom were infected with T. cruzi. One hundred sixty-nine patients had CCC, and 76 were asymptomatic.. Results. Genotype distributions differed between the CCC and asymptomatic ...
A total of 130 patients were included; mean age was 53.6 ± 11.5 years, and 53.9% were female. The majority of patients reported no symptoms of heart failure or arrhythmia, but electrocardiographic and echocardiographic abnormalities were common. On CMR, left ventricular dilatation and dysfunction were frequent, and MF was found in 76.1%, with a mean mass of 15.2 ± 16.5 g. Over a median follow-up of 5.05 years, 58 (44.6%) patients reached the combined endpoint, and 45 (34.6%) patients died. MF was associated with the primary outcome as a continuous variable (adjusted hazard ratio: 1.031; 95% CI: 1.013 to 1.049; p = 0.001) and as a categorical variable (MF ≥12.3 g) (adjusted hazard ratio: 2.107; 95% CI: 1.111 to 3.994; p = 0.022), independently from the Rassi risk score. MF expressed as a continuous variable was also associated with all-cause mortality (adjusted hazard ratio: 1.028; 95% CI: 1.005 to 1.051; p = 0.017) independently from the Rassi risk score ...
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LEMOS DE OLIVEIRA, LUCIANO FONSECA... Regional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy. JOURNAL OF NUCLEAR MEDICINE 59 n.9 p. 1430-1436 SEP 1 2018. Journal article.
Introduction: Scar in Chagas heart disease (CHD) is thought to be predominantly epicardial and requires epicardial access for ventricular tachycardia (VT) ablation. However, little data exists on scar patterns in this population. We evaluated the patterns of scar in patients who underwent magnetic resonance imaging (MRI) with delayed enhancement (DE).. Methods: 19 patients were enrolled who had evidence of DE by MRI: 4 (21.0%) patients with normal electrocardiogram (ECG) and normal echocardiogram (echo) (group 1); 3 (15.8%) patients with abnormal ECG and normal echo (group 2); and 12 (63.2%) patients with abnormal ECG and echo (group 3).. Results: In the 19 patients, there were 110 segments (34.1%) with DE identified using a 17-segment model. Pattern of involvement is as follows: endocardial 30 (27.3%), mid-myocardial 22 (20.0%), epicardial 2 (1.8%) and transmural 56 (50.9%). Most common territories of involvement are as follows (% of patients with segment involved): Basal inferolateral (78.9%), ...
Introduction: Left ventricular (LV) remodeling in Chagas heart disease (CHD) depends on the severity of the initial insult and may have clinical implication. SEARCH-Rio study investigated nonlinear dynamics in long-term LV remodeling in CHD.. Methods: Fifty stable outpatients with CHD were enrolled and followed at scheduled visits. Cardiac death (sudden, arrhythmic or heart failure) was ascertained by review of medical records. LV dimension was assessed by echocardiogram, and mass estimated by Devereux. Subjects were distributed in four equally spaced groups according to initial mass. Intra-group standard deviation (SD) was calculated throughout follow-up. A plot of LV mass (corrected to initial value) vs recurrences during follow-up assessed non-linear relationship. Lyapunov exponent (LE) assessed LV mass dynamics during follow-up.. Results: Median follow-up was 95 months; 10 subjects died. LV mass groups were [mean; Figure 1]: I-110g, II-140g, III-170g, IV-200g. No inter-group SD differences ...
Chagas´ disease is an endemy caused by the protozoa Trypanosoma cruzi, which is spread from southern United States to Argentina. According to data from the World Health Organization, up to 20 million people may be infected in South America, thus making this disease a very important public health problem. This disease occurs naturally in several animal species, despite data still lacks about natural infection in dogs. Thus, this work aimed to characterize Chagas´ disease of natural occurrence in three adult dogs from Western Brazil.. Animals were referred to the Cardiology Service of the Veterinary Teaching Hospital of São Paulo State University (Unesp), Campus of Jaboticabal, Brazil, where they were evaluated. After serologic testing by indirect immunofluorescence for Trypanosoma cruzi, dogs were considered positive to such disease, owing to the high positive titles: 1:2560, 1:1280 and 1:320. Moreover, it was also performed a serologic test to differentiate from Leishmaniasis, which was ...
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. (MeSH ...
Methods and Results Nineteen patients with CC undergoing detailed epicardial and endocardial LV tachycardia mapping and ablation were included. A total of 8494 epicardial and 6331 endocardial voltage signals and 314 epicardial/endocardial matched pairs of points were analyzed. Basal lateral LV scar involvement was observed in 18 of 19 patients. Bipolar voltage mapping demonstrated larger epicardial than endocardial scar and core-dense (≤0.5 mV) scar areas (28 [20-36] versus 19 [15-26] and 21 [2-49] versus 4 [0-7] cm2; P=0.049 and P=0.004, respectively). Bipolar epicardial and endocardial voltages within scar were low (0.4 [0.2-0.55] and 0.54 [0.33-0.87] mV, respectively) and confluent, indicating a dense/transmural scarring process in CC. The endocardial unipolar voltage value (with a newly proposed ≤4-mV cutoff) predicted the presence and extent of epicardial bipolar scar (P,0.001). ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
Despite major advances in cardiovascular therapies, CHD still stands as an important cause of premature death in Latin America. Although the number of new cases of Chagas disease has decreased steadily since the late 1990s, many chronic cases are still part of routine care in public hospitals where patients with lower income have access to treatment. Moreover, decreased barriers to international travel and migration has led to an increase in migration of patients from Chagas disease-affected areas to nonendemic countries of North America and Europe. This globalization phenomenon transformed Chagas disease into a global medical challenge [39, 40].. CHD treatment is based on trials that studied the effect of different drugs on ventricular dysfunction, survival, and quality of life in patients with cardiomyopathies from other etiologies [4, 41]. However, CHD has a specific autonomic imbalance, a different pattern of myocardial fibrosis associated with an inflammatory milieu generated by parasite ...
Bautista-Lopez NL, Morillo CA, Lopez-Jaramillo P, Quuiroz R, Luengas C, Silva SY, Galipeau J, Lalu MM, Schulz R. (2013) Matrix metalloproteinase-2 and -9 as diagnostic markers in the progression to Chagas cardiomyopathy. Am Heart J 165:558-566. PMID: 23537973.. ZAHRAN, S., FIGUEIREDO, V., GRAHAM, M.M., SCHULZ, R., and HWANG, P.M. (2018). Proteolytic digestion of serum cardiac troponin I as a marker of ischemic severity. J Appl Lab Med. 3:450-455 ...
As we ring in the new year, the January 2018 issue of JASE debuts with Michael H. Picard, MD, FASE, as Editor-in-Chief, his first editorial, "JASE 3.0: Entering our 4th Decade," and a new cover design! The issue also features Recommendations for Multimodality Cardiac Imaging in Patients with Chagas Disease: A Report from the American Society of Echocardiography in Collaboration With the InterAmerican Association of Echocardiography (ECOSIAC) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DIC-SBC). The writing group for this important paper was led by Harry Acquatella, MD, FACC, FAHA, FASE, MACP, of Centro Medico de Caracas in Caracas, Venezuela (Chair), one of the worlds foremost experts on Chagas heart disease and Federico Asch, MD, FASE, of MedStar Washington Hospital Center in Washington, DC (Co-chair). Dr. Asch commented, "While historically it has been rare in the U.S., migration has changed the epidemiology of Chagas Heart Disease. However, there is ...
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RESUMEN. El objetivo de esta investigacion fue determinar compromiso cognitivo en pacientes con enfermedad de Chagas en estadio cronico. Se estudio el perfil cognitivo de 45 pacientes chagasicos cronicos (CC) y 26 controles apareados por edad, educacion, lugar y tiempo de residencia en area endomica. El Minimental State (MMSE), 1 a escala de memoria de Weschler (WMS) y el test de Inteligencia de Weschler (WAIS) han sido utilizados para evaluar ambos grupos. Para el estudio estadístico de los datos se utilizaron pruebas no paramotricas, Chi2 y estadistica multivariada en tabla de 2x2 para medir la association o independencia de variables categoriales con la presencia de enfermedad. Los resultados mostraron que los pacientes alcanzaban score menor que los controles en el MMSE (p,0.004) debido basicamente a una mas pobre orientacion (P,0.004) y atencion (p,0.007). Cocientes bajos de memoria en el WMS se asociaron a la presencia de enfermedad (Chi2 5.9, p,0.01; test de Fisher p,0.02). Cocientes ...
Rationale: Autoantibodies directed against the second extracellular loop of the cardiac beta1-adrenergic receptor (β1-AR) are thought to contribute to the pathogenesis of dilated cardiomyopathy (DCM) and Chagas heart disease. Various approaches have been employed to detect such autoantibodies; however, the reported prevalence varies largely depending on the utilized detection method. Objective: We analysed sera from 167 DCM patients (ejection fraction , 45%), and from 110 age-matched volunteers, who did not report any heart disease themselves, with an often employed simple peptide-ELISA approach, and compared it to a novel whole cell-based ELISA using cells expressing the full transgene for the human β1-AR. Additionally, 35 patients with hypertensive heart disease (HHD) with preserved ejection fraction were investigated. Methods and Results: The novel assay was designed according to the currently most reliable anti-TSH receptor antibody-ELISA used to diagnose Graves disease ("third ...
The etiologies of cerebral infarcts have always been under scrutiny. As it stands today, about a third of strokes are still cryptogenic. The impact of stroke does not need to be emphasized to the audience of this blog. Despite staggering data with modern technological advances, a significant percentage of stroke patients remain a mystery. The solace is that we have made some advances, wherein I can introduce this hot topic of discussion: atrial cardiopathy.. The term atrial cardiomyopathy was first published in 1972, to describe a familial syndrome affecting the atria and atrioventricular system with resultant rhythm abnormalities. The term has percolated through the years, evolving in its definition. The current definition for atrial cardiopathy, created by the European Heart Rhythm Association, is the most accepted one: any complex structural, architectural, contractile or electrophysiological changes affecting atria with potential to produce clinically relevant manifestations. This suggests ...
This course is a sequel to MATH 100 for those students who wish to major in mathematics, sciences or applied sciences. The course includes: antidifferentiation and integration; the definite integral; areas and volumes; transcendental functions; techniques of integration; parametric equations; polar coordinates; indeterminate forms, improper integrals and Taylors formula; and infinite series.
A little-known disease called Chagas is much more prevalent than Zika. Heres how advocates fought an uphill battle, and won ...
Trypanosoma cruzi (T. cruzi) infection reactivation is a constant threat for Chagas heart transplant recipients. The incidence of clinical T. cruzi infection reactivation varies from 27% to 90% and manifestsby paniculitis and/or myocarditis and more rarely by intracerebral Six (43%) out of 14 patients had documented T. cruzi infection reactivation: 3 in the heart, and 3 in the subcutaneous tissue. Six The histological aspect of myocardial T. cruzi infection reactivation (43%) patients had acute myocardial inflammation consistent with on endomyocardial biopsy usually mimics acute graft rejection. This acute rejection graded 3A or more, which had not improved with might lead to inadvertent treatment with steroid pulsotherapy, steroid pulsotherapy, but improved after specific treatment for dissemination of T. cruzi infection, or septicemia due to opportunistic T. cruzi infection (benznidazol, 5 mg/kg, during 60 days). Such The aim of this study, therefore, was to look for other risk factors for ...
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Current diagnosis of chronic Chagas disease relies on serologic detection of specific immunoglobulin G against Trypanosoma cruzi. However, the presence of parasites detected by polymerase chain reaction (PCR) in patients without positive conventional serologic testing has been observed. We determined the prevalence and clinical characteristics of persons with seronegative results and T. cruzi DNA detected by PCR in a population at high risk for chronic American trypanosomiasis. We studied a total of 194 persons from two different populations: 110 patients were recruited from an urban cardiology clinic, and 84 persons were citizens from a highly disease-endemic area. Eighty (41%) of persons had negative serologic findings; 12 (15%) had a positive PCR. Three patients with negative serologic findings and positive PCR results had clinical signs and symptoms that suggested Chagas cardiomyopathy. This finding challenges the current recommendations for Chagas disease diagnosis, therapy, and blood ...
Current diagnosis of chronic Chagas disease relies on serologic detection of specific immunoglobulin G against Trypanosoma cruzi. However, the presence of parasites detected by polymerase chain reaction (PCR) in patients without positive conventional serologic testing has been observed. We determined the prevalence and clinical characteristics of persons with seronegative results for T. cruzi DNA detected by PCR in a population at high risk for chronic American trypanosomiasis. We studied a total of 194 persons from two different populations: 110 patients were recruited from an urban cardiology clinic, and 84 persons were nonselected citizens from a highly disease-endemic area. Eighty (41%) of persons had negative serologic findings; 12 (15%) had a positive PCR. Three patients with negative serologic findings and positive PCR results had clinical signs and symptoms that suggested Chagas cardiomyopathy. This finding challenges the current recommendations for Chagas disease diagnosis, therapy, and blood
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Although low-grade parasite persistence is a fundamental aspect of chronic Chagas disease, current parasitological assays have low sensitivity and are not quant...
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This laboratory investigates the pathogenesis of chagasic heart disease, caused by the parasite Trypanosoma cruzi. Chagas disease is also an opportunistic infection in HIV/AIDS. We are examining signaling pathways involved in cardiac remodeling as a consequence of the T. cruzi infection. This laboratory is examining the consequences of this infection on cell cycle regulatory proteins (i.e., cyclins) in vitro. Previously, we found that infection induces ERK activation and modulation of the expression and/or activity of cyclins, which function as mediators of cellular proliferation and differentiation. Cyclins are also responsible for remodeling in the cardiovascular system. Therefore, the kinetics of the expression of cyclins in infected cultured cells and co-culture systems are to be studied. In addition, in the mouse model of Chagas disease the kinetics of expression of cell cycle regulatory proteins in the cells of the myocardium of infected mice will be determined and correlated with ...
Trypanosoma cruzi, the protozoan that causes Chagas heart disease, invades endothelial cells in vitro by activating the B-2 kinin receptor (B2R). Here, we demonstrate that mice infected with trypomastigotes develop potent edema after treatment with the angiotensin-converting enzyme (ACE) (or kininase II) inhibitor captopril. Experiments performed with specific kinin receptor (B2R/B1R) antagonists and knockout mice revealed that the early-phase (3-h) edema is mediated by the constitutive B2R, whereas the late-phase (24-h) response depends on stimulation of the up-regulated B1R. Given previous evidence that parasite invasion of cells expressing B2R is potentiated by captopril, we investigated the prerequisites for in vitro infection of Chinese hamster ovary cells overexpressing either B1R or B2R, human umbilical vein endothelial cells activated by lipopolysaccharide, and neonatal rat cardiomyocytes. Our results indicate that captopril potentiates parasite invasion regardless of the kinin ...
Background :Chagas disease is an endemic disease in most Latin American countries. The cardiomyopathy associated with this condition often requires permanent pacing due to bradycardia. The aim of this study was to compare the indications for pacemaker implantation, intraoperative measurements, and long-term follow-up of patients with Chagas cardiomyopathy (ChCM) and ischemic cardiomyopathy (ICM) referred for pacemaker implantation.. Methods : Retrospective study including consecutive patients with ChCM (Group 1) and ICM (Group 2), who underwent pacemaker implantation in a single center.. Results : We analyzed 360 patients. Patients in Group 1 were younger (66.29 ± 7.01 vs 75.3 ± 7.11 years; P = 0.0001) and more often male (72% vs 60%; P = 0.05). Sinus node dysfunction (SND) was more prevalent in Group 1 (70% vs 52%; P = 0.03). Atrioventricular block was less prevalent in Group 1 (30% vs 48%; P = 0.04). No significant differences were found with respect to left ventricular ejection fraction ...
Background Chagas disease induced by (invasion and in sponsor tissue fibrosis. become inhibited by this compound. Interestingly we further shown that administration of "type":"entrez-nucleotide" attrs :"text":"GW788388″ term_id :"293585730″ term_text :"GW788388″GW788388 at the end of the acute phase (20 dpi) still significantly increased survival and decreased cardiac fibrosis (evaluated by Massons trichrome staining and collagen type I manifestation) inside a stage when parasite growth is no more central to this event. Summary/Significance This work confirms that inhibition of TGF? signaling pathway can be considered like a potential alternate strategy for the treatment of the symptomatic cardiomyopathy found in the acute and chronic phases of Chagas disease. Author Summary Cardiac damage and dysfunction are prominent features in individuals with chronic Chagas disease which is definitely caused by illness with the protozoan parasite (invasion and growth and in sponsor tissue fibrosis. ...
The evolution of Chagas cardiomyopathy is poorly understood. We therefore examined the development of cardiac lesions in a rural Brazilian community for a period of 7 years. Initially, 42% of 1017 residents were seropositive for infection with Trypa
Chagas disease is diagnosed using blood tests, but different kinds of blood tests are needed for acute and chronic Chagas disease.
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Chagas is a deeply misunderstood disease that affects about eight million people around the world, primarily in Latin America, and is responsible for 10,000 deaths a year, according to the World Health Organization. It is estimated that 300,000 people in the United States have it, per the U.S. Centers for Disease Control and Prevention. … A majority of people with Chagas in the U.S. likely acquired it in one of 21 Latin-American countries … Research suggests many of the most at-risk people probably wont get care for the disease in America…" (Smith, 8/29).. ...
World Chagas Day is tomorrow, April 14, 2018. This world health day is designed to raise awareness of a rarely talked about and frequently silenced disease. Chagas is considered silenced because its transmission is linked to poverty and its magnitude, even in the 21st century, is largely unknown.
Researchers used arrays with more than 175,000 peptides matching sections of the Chagas pathogen proteome to characterize novel elements of the immune response to infection.
\Trypanosoma cruzi\ é o agente etiológico da doença de Chagas, esta considerada um problema de saúde pública na América Latina. Cerca de 10 a 14 milhões de pessoas estão infectadas com o \Trypanosoma...
... laboratory is within their headquarters: Av. Carlos Chagas Filho, 791 Cidade Universitária - Rio de Janeiro - RJ - Brasil - 21.941-904
TY - JOUR. T1 - Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease. AU - Matos Ferreira, Adaliene Versiani. AU - Segatto, Marcela. AU - Menezes, Zélia. AU - Macedo, Andréa Mara. AU - Gelape, Cláudio. AU - de Oliveira Andrade, Luciana. AU - Nagajyothi, Fnu. AU - Scherer, Philipp E.. AU - Teixeira, Mauro Martins. AU - Tanowitz, Herbert B.. PY - 2011/11/1. Y1 - 2011/11/1. N2 - Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.. AB - Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected ...
Hayes, M M. and Kierszenbaum, F, "Experimental chagas disease: kinetics of lymphocyte responses and immunological control of the transition from acute to chronic trypanosoma cruzi infection." (1981). Subject Strain Bibliography 1981. 1540 ...
The protozoan parasite Trypanosoma cruzi (T. cruzi) circulates in the blood upon infection and invades a variety of cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase. Natural killer (NK) and NKT cells play an important role in the immune control of T. cruzi infection, mainly by releasing the cytokine IFN-γ that activates the microbicidal action of macrophages and other cells and shapes a protective type 1 immune response. The mechanisms by which immune cells are regulated to produce IFN-γ during T. cruzi infection are still incompletely understood. Here, we show that urokinase plasminogen activator (uPA) is induced early upon T. cruzi infection, and remains elevated until day 20 post inoculation. We previously demonstrated that the inhibitory receptor Ly49E, which is expressed, among others, on NK and NKT cells, is triggered by uPA. Therefore, we compared wild type (WT) to Ly49E knockout (KO) mice
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Chagas Disease Therapeutics market report covers research informatics related to Chagas Disease Therapeutics clinical trials, such as a listing of industry and sponsored clinical trials as well as new drug therapies.. Designed to be a resource both for patients interested in participating in Chagas Disease Therapeutics clinical trials and for research professionals.. The report, "Chagas Disease Therapeutics Global Clinical Trials Review, H2, 2016″ provides an overview of Chagas Disease Therapeutics clinical trials scenario. This report provides top line data relating to the clinical trials on Chagas Disease Therapeutics. Report includes an overview of trial numbers and their average enrolment in top countries conducted across the globe. The report also offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type.. Browse Detailed TOC, Tables, ...
Chronic Chagas disease presents different clinical manifestations ranging from asymptomatic (namely indeterminate) to severe cardiac and/or digestive. Previous results have shown that the immune response plays an important role, although no all mechanisms are understood. Immunoregulatory mechanisms such as apoptosis are important for the control of Chagas disease, possibly affecting the morbidity in chronic clinical forms. Apoptosis has been suggested to be an important mechanism of cellular response during T. cruzi infection. We aimed to further understand the putative role of apoptosis in Chagas disease and its relation to the clinical forms of the disease. Apoptosis of lymphocytes, under antigenic stimuli (soluble T. cruzi antigens - TcAg) where compared to that of non-stimulated cells. Apoptosis was evaluated using the expression of annexin and caspase 3+ by T cells and the percentage of cells positive evaluated by flow cytometry. In addition activation and T cell markers were used for the
Amongst adult cats, myocardial disease (cardiomyopathy) is the most common form of heart disease. Hypertrophic cardiomyopathy (HCM) is identified in over 60% of cardiomyopathic cats, with the rest attributable to dilated cardiomyopathy, restrictive cardiomyopathy (endomyocardial or myocardial), arrhythmogenic right ventricular cardiomyopathy, and "unclassified" cardiomyopathy.. The criteria by which each form of cardiomyopathy is defined are based on echocardiographically-derived parameters; however, there is some overlap between categories, which results in controversy over the classification of some individuals. Of greater importance for these individuals is correct identification of the type of functional abnormality (e.g., systolic dysfunction, diastolic dysfunction, or both), as this has direct implications for patient management.. While pathophysiology of the feline cardiomyopathies differs, affected cats are at risk for the same three adverse sequelae: congestive failure, thromboembolic ...
Purpose: The mechanism of J-wave is not definitely known, although it is generally considered to be a manifestation of ventricular repolarization abnormality. We investigated the current flow consistent with J-wave on electrocardiogram (ECG) using 3-directional magnetocardiography(MCG)with high spacio-temporal resolution.. Methods: Sixty-four-channel 3-D MCG was recorded simultaneously with a digitalized ECG (II, V2, V5) during sinus rhythm in 69 patients (men 54, women 15, mean age 49.2±21.6 ) absence of bundle branch block but with J-wave showing either notched or slurred J-point elevation,0.1mV in at least 2 consecutive leads followed by ST elevation. We compared the direction and distribution of current flow on MCG at the time phase of J-wave with that of the mid to late QRS and ST-T period.. Results Twenty-four patients had organic heart diseases (cardiomyopathy;6, ischemic heart disease;5). 4 of them and 12 of 45 patients without heart disease had episodes of lethal ventricular ...
The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptured parasite nests release T. cruzi antigens that bind to the cell surface in the vicinity which become targets for the cellular and humoral immune response against T. cruzi. The various factors involved in the genesis of autoimmunity in chronic T. cruzi infection include molecular mimicry, presentation of self-antigens and imbalance of immune regulation ...
Symptoms of Chagas disease including 49 medical symptoms and signs of Chagas disease, alternative diagnoses, misdiagnosis, and correct diagnosis for Chagas disease signs or Chagas disease symptoms.
Current treatment is dependent on two drugs, benznidazole or nifurtimox, both of which are highly effective when therapy is initiated at the onset of infection and during the acute phase of the disease. However, very few patients are diagnosed in the acute stages because many people are asymptomatic when first infected, or because the patients do not have access to proper diagnosis and treatment.. The efficacy of both drugs for many patients with chronic Chagas disease diminishes the longer a person has been infected. Available drug treatments have a high level of toxicity and cause side effects severe enough to require interruption of treatment in some patients. Thus, the benefits of medication in preventing or delaying the development of Chagas disease has to be weighed against the long duration of treatment (up to two months) and relatively high rates of adverse reactions that occur in up to 40 percent of treated patients. Additionally, there is currently no available drug intervention for ...
Trypanosoma cruzi is the etiologic agent of Chagas disease. The contributions of parasite and immune system for disease pathogenesis remain unresolved and controversial. The possibility that Chagas disease was an autoimmune progression triggered by T. cruzi infection led some to question the benefit of treating chronically T. cruzi-infected persons with drugs. Furthermore, it provided the rationale for not investing in research aimed at a vaccine which might carry a risk of inducing autoimmunity or exacerbating inflammation. This viewpoint was adopted by cash-strapped health systems in the developing economies where the disease is endemic and has been repeatedly challenged by researchers and clinicians in recent years and there is now a considerable body of evidence and broad consensus that parasite persistence is requisite for pathogenesis and that antiparasitic immunity can be protective against T. cruzi pathogenesis without eliciting autoimmune pathology. Thus, treatment of chronically ...
Chagas disease: Chagas disease, infection with the flagellate protozoan Trypanosoma cruzi. It is transmitted to humans by bloodsucking reduviid bugs and is endemic in most rural areas of Central and South America. The disease is most often transmitted by contact with the feces of infected insects, commonly through
strain were analyzed, during acute and chronic infection, by means of histological, histochemical, morphometric and electron microscopic techniques. No evidences of destructive changes were apparent. Histochemical demonstration for acetylcholinesterase and catecholamines did not reveal differences in the amount and distribution of intracardiac nerves, in mice with acute and chronic Chagas myocarditis or in non-infected controls. Mild, probably reversible ultrastructural neural changes were occasionally present, especially during acute myocarditis. Intrinsic nerves appeared as the least involved cardiac structure during the course of experimental Chagas disease in mice ...
The etiological treatment of Chagas disease is recommended for all patients with acute or recent chronic infection, but controversies remain regarding the benefit of chemotherapy and interpretations of the parasitological cure after etiological treatment. This study compares the laboratory and clinical evaluations of Chagas disease patients who were diagnosed 13 years earlier. Fifty-eight Chagas disease patients (29 treated with benznidazole and 29 untreated) were matched at the time of treatment based on several variables. Conventional serology revealed the absence of seroconversion in all patients. However, lower serological titres were verified in the treated group, primarily among patients who had the indeterminate form of the disease. Haemoculture performed 13 years after the intervention was positive for 6.9% and 27.6% of the treated and untreated patients, respectively. Polymerase chain reaction tests were positive for 44.8% and 13.8% of the treated and untreated patients, respectively. ...
A specific test is necessary for the diagnosis of Chagas disease. The test detects the presence of the infection through analysis of a blood sample. Anyone who suspects that they may have Chagas disease should ask their doctor to order this test.. Patients who test positive for the infection should have a cardiac check-up. This is done using radiography, an electrocardiogram and occasionally an echocardiogram. Depending on whether or not the patient reports digestive symptoms, the doctor will decide if a digestive tract assessment is needed.. To find out whether you should be tested for Chagas infection, we recommend you take the following test.. ...
The only existing preventive measure against American trypanosomosis, or Chagas disease, is the control of the transmitting insect, which has only been effective in a few South American regions. Currently, there is no vaccine available to prevent this disease. Here, we present the clinical and cardiac levels of protection induced by expression to Trypanosoma cruzi genes encoding the Tc SP and Tc SSP4 proteins in the canine model. Physical examination, diagnostic chagasic serology, and serial electrocardiograms were performed before and after immunization, as well as after experimental infection. We found that immunization with recombinant plasmids prevented hyperthermia in the acute phase of experimental infection and produced lymphadenomegaly as an immunological response against the parasite and additionally prevented heart rate elevation (tachycardia) in the acute and/or chronic stages of infection. Immunization with T. cruzi genes encoding the Tc SP and Tc SSP4 antigens diminished the quality and
The ICD-10 Code B57.5 is the code used for Chagas disease (chronic) with other organ involvement .An alternative description for this code is Chagas disease (chronic) with other organ ...
The ICD-10 Code B57.2 is the code used for Chagas disease (chronic) with heart involvement .An alternative description for this code is Chagas disease (chronic) with heart ...
Researchers have shown that the Trypanosoma cruzi agent of Chagas disease invades host embryo cells and spreads its mitochondrial DNA (kDNA) minicircles into the hosts genome. Dr. Antonio Teixeira and associates at the University of Brasília, Brazil, inoculated virulent typanosomes in fertile chicken eggs and documented the heritability and fixation of the kDNA mutations in the chicks and their progeny. The results show that kDNA-mutated chickens undergo genotype alterations, developing an inflammatory heart condition similar to Chagas disease in humans.
Rick Tarleton of the Center for Tropical and Emerging Global Diseases at the University of Georgia and the Chagas Disease Foundation, and colleagues provide background on Chagas disease and discuss the Chagas-related milestones identified by the London Declaration on Neglected Tropical Diseases, as well as the actions necessary to control and eventually eliminate the disease (10/9).. ...
Health, This release is available in A HREF http://www.eurekalert....Rio de Janeiro and Recife Brazil and Geneva Switzerland 2 December...This new tablet means easier-to-administer and safer treatment of Chag...Until today benznidazole was available only as a 100-mg tablet for ad...Chagas disease infects an estimated 8 to 10 million people mostly in ...,New,child-adapted,Chagas,disease,treatment,approved,for,registration,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Chagas disease, inspiring millions of people in Central and South America, is personal as one of a 17 many critical neglected diseases by a World Health Organization. Now, researchers have found that even a non-symptomatic theatre of Chagas infection, that can final for many years, some-more than doubles a persons […]
Infected animals may remain subclinical for years or may infrequently produce a variety of clinical effects such as anorexia, dyspnea, fever, leukocytosis, lymphadenopathy and myocarditis. During remission, the parasite may remain undetectable in the blood for long periods, then return to detectable levels periodically, often triggered by stress or immune system challenge. In humans, reactivation of Chagas disease in patients infected with the human immunodeficiency virus (HIV) has been reported since the early 1990s. The clinical manifestations of reactivated Chagas disease are severe central nervous system (CNS) alterations and cardiomyopathy. Trypomastigotes of T. cruzi, observed by direct microscopic examination of blood smears, characterize the acute phase of infection and confirm Chagas disease reactivation.. Traditional laboratory diagnosis of T. cruzi relies on blood smear observation or serological detection. Unfortunately, these methods lack sensitivity and specificity. PCR ...
Background: This study investigates morphofunctional adaptations of the heart stroma and parenchyma in rats that are chronically infected with Trypanosoma cruzi. Methods: Four-month-old male Wistar rats were randomized into control (n=14) and infected (n=14) groups. Infected animals were inoculated with T. cruzi Y strain. After 9 weeks, the animals were euthanized, and the right atrium (RA) and left ventricle (LV) were removed for biochemical, stereological, and cardiomyocyte mechanical analyses. Results: Infected animals presented cardiomyocyte atrophy and myocardial fibrosis. For these animals, the total volume, length, surface area, and cross-sectional area of cardiomyocytes were significantly reduced, and the total interstitial and collagen volumes were significantly increased in the RA and LV compared to the controls. The total volume and length of blood vessels were significantly increased in the LV, and the total blood vessel surface area was significantly higher in the RA of infected ...
Abstract: Trypanosoma cruzi trans sialidase (TcTS) has been identified as a potential therapeutic target for treatment of Chagas disease.
Chagas disease is the single most common cause of congestive heart failure and sudden death in the world. The devastating parasitic infection affects millions of people throughout Central and South America. But as global travel increases, its becoming a greater threat in the United States and Europe as well.
The first large-scale epidemiological study of Chagas disease in the US confirms it is a major public health challenge for the country.
Important It is possible that the main title of the report Chagas Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. ...
By Orlando Jenkinson, Herald Staff (This article and its content were first published in the Buenos Aires Herald (print edition), August 28, 2015) www.buenosairesherald.com/article/197430/report-chagas-a-scourge-for-15-million-argentines One of the most wide-spread but little-known infectious diseases in Argentina will be thrust into the spotlight today as the National Day For Argentina Without Chagas is marked. The government-backed campaign,…
FINDECHAGAS has launched an online petition through the platform change.org in support of the official declaration of April 14th as World Chagas Day.
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June 1. 2012 - DISEASE - Chagas, a tropical disease spread by insects, is causing some fresh concern following an editorial-published earlier this week in a medical journal-that called it the new AIDS of the Americas.
Dimensions: 18 x 3.5 x 4.5 cm. Power: 10W (Adaptor). Voltage: 220V 50Hz. Weight: 150g. Directions of use: Clean your breast and keep it wet to allow easy transmission of electricity. You can also apply some cream on the breast before use. Use 3-4 times per week. Do not exceed 15 minutes per session and not more than 5 to 7.5 minutes for each breast. If your breast does not feel stimulated, increase the intensity of the electric current and vice versa.. Warning: Pregnant women, women who need to nurse, people with cardiopathy and people who have just undergone operations should not use this instrument.. ...
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DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
TY - JOUR. T1 - Risedronate in the treatment of Murine Chagas disease. AU - Bouzahzah, Boumediene. AU - Jelicks, Linda A.. AU - Morris, Stephen A.. AU - Weiss, Louis M.. AU - Tanowitz, Herbert B.. PY - 2005/6/1. Y1 - 2005/6/1. N2 - Risedronate, a bisphosphonate, was used to treat CD-1 mice infected with the Brazil strain of Trypanosoma cruzi. When given by subcutaneous injection 3 times/week, there was a significant reduction in mortality, however, the myocardial pathology and right ventricular dilation was unchanged in these mice compared to control animals. In C57BL/6 mice infected with the Tulahuen strain, there was no change in mortality in response to risedronate treatment. These data suggest that this class of compounds has activity against T. cruzi in vivo and illustrate the utility of imaging and pathologic studies as adjuncts in the evaluation of therapeutic compounds as treatments for experimental Chagas disease. In addition, it underscores the need to use different strains of T. ...
La enfermedad de Chagas en Argentina. Investigación científica, problemas sociales y políticas sanitarias [Chagas disease in Argentina. Scientific research, social problems and health policies]. By Juan Pablo Zabala. Universidad Nacional de Quilmes, Argentina. 2010. 360 pages.. "Mal de Chagas" is a disease that affects 2.5 million people in Argentina and 8 million in Latin America. Caused by the parasite Trypanosoma cruzi, it generates heart, digestive and/or nervous system problems that may lead to death. The main vector of contagion is an insect (in Argentina, called "vinchuca", in Brazil, "barbeiro"), which nests in the walls and roofs of dilapidated huts. Chagas disease is effectively a disease of poverty, as its transmission is associated with deficient housing, insufficient material conditions and sanitation facilities, malnutrition, and lack of access to sanitary information.. Chagas is considered a "neglected disease". This is due to: the lack of overt symptoms; the lack of ...
W Apt. University of Chile, Santiago, Chile. Chapter Outline. Introduction 751. Drugs which inhibit protein or purine synthesis 752 Inhibitors of ergoesterol 753 Ofloxacine 755. Inhibitors of trypanothione metabolism 756 Inhibitors of cysteine protease (CPI) 758 Inhibitors of phospholipids 758 Inhibitors of pyrophosphate metabolism 758 Natural drugs 759 Other drugs 760. Treatment of human infection 760. Current drug therapy 760 Acute cases 762 Congenital infection 762 Accidental Chagas disease 764 Organ transplants 764. Reactivations of chronic Chagas disease and treatment of Chagas disease in immunosuppressed patients 764. Evaluation and follow-up of specific therapy 765 Resistance of T. cruzi to drugs 765 Critical comments 766 Glossary 767 References 767. Introduction. Chagas disease has existed for at least 9000 years. Of the desiccated human mummies from coastal valley sites in northern Chile and Peru, 41% were found to be positive by polymerase chain reaction (PCR) and hybridization probes ...
Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi. The organism T cruzi and infection in humans were first described in 1909 by the Brazilian physician Carlos R.
TY - JOUR. T1 - Chagas disease awareness among Latin American immigrants living in Los Angeles, California. AU - Sanchez, Daniel R.. AU - Traina, Mahmoud I.. AU - Hernandez, Salvador. AU - Smer, Aiman M.. AU - Khamag, Haneen. AU - Meymandi, Sheba K.. PY - 2014/11/1. Y1 - 2014/11/1. N2 - Approximately 300,000 persons have Chagas disease in the United States, although almost all persons acquired the disease in Latin America. We examined awareness of Chagas disease among Latin American immigrants living in Los Angeles, California. We surveyed 2,677 persons (age range = 18-60 years) in Los Angeles who resided in Latin America for at least six months. A total of 62% of the participants recalled seeing triatomines in Latin America, and 27% of the participants reported triatomine bites at least once per year while living abroad. A total of 86% of the participants had never heard of Chagas disease. Of persons who had heard of Chagas disease, 81% believed that it was not serious. More than 95% of those ...
You may have heard about the kissing bug that is making its way across southern regions of the U.S. Major news outlets such as TIME, CNN, and Forbes recently featured stories about this trending topic. Kissing bugs can carry the parasite Trypanosoma cruzi, which can cause Chagas disease. Its important to know that not all kissing bugs are infected with the parasite, and the likelihood of contracting Chagas disease is low.. The Kissing bug received its name because it typically bites the face of humans around the lips and eyes. They are similar to bed bugs; they are primarily nocturnal, and feed on the blood of mammals, including dogs and people. Feedings typically occur while hosts are asleep, and a meal can last 20-30 minutes. Hosts are unaware they are being bitten, because kissing bugs inject an anesthetizing agent during feeding.. About Chagas disease. Chagas disease is not new, but until recently, it was more commonly found in Mexico, Central America and South America. The disease is ...
While many studies have found associations between climate change and factors affecting Chagas disease transmission, the future impact of climate change on the global spread of Chagas disease remains debatable. A qualitative, systematic review was conducted to assess the impact of climate change on Chagas disease transmission in the Americas (Central America, South America, and North America). The literature search was performed in January 2019 using the keywords climate, Chagas, and
Papain-like cysteine proteases are important for the survival of the flagellated protozoa Trypanosoma cruzi, the causative agent of Chagas Disease. the lysosomal cysteine protease designated as cruzipain or cruzain, is the archetype of a multigene family of related isoforms. We investigated the substrate specificity of the cruzipain 2 isoform using internally quenched fluorogenic substrates. We found that cruzipain 2 and cruzain differ substantially regarding the specificity in the S-2, S-1() and S-2() pockets. Our study indicates that cruzipain 2 has a more restricted specificity than cruzain, suggesting that these isoforms might act on distinct natural substrates ...
Autonomic disease imparted by Chagas may eventually result in megaesophagus, megacolon and accelerated dilated cardiomyopathy. ... Chagas information at the U.S. Centers for Disease Control. *Chagas information from the Drugs for Neglected Diseases ... "Enfermedad de Chagas - Mazza" (in Spanish). Asociación Lucha Contra el Mal de Chagas. Archived from the original on 16 ... Megazol in a study seems more active against Chagas than benznidazole but has not been studied in humans.[76] A Chagas vaccine ...
Chagas' disease represents a parasitic nonischemic cardiomyopathy targeting parasympathetic inflow to the heart. Chagas' ... and 100 patients with non-ischemic cardiomyopathy, mostly idiopathic dilated cardiomyopathy... ...expanding on patient ... May 2001). "Partial left ventriculectomy for dilated cardiomyopathy: is this an alternative to transplantation?". J. Thorac. ... Many of his patients were victims of Chagas' Disease. ... Cardiomyopathy thus represents a unique method of study of ...
Researchers of Chagas' disease have demonstrated several processes that occur with all cardiomyopathies. The first event is an ... Another cardiomyopathy found in nearly all cases of chronic Chagas' disease is thromoembolic syndrome. Thromboembolism ... Chagas disease undergoes two phases which are the acute and chronic phase. The acute phase can last from two weeks to two ... Chagas, C. 1909b. Nouvelle espèce de trypanosomiase humaine. Bulletin de la Société de Pathologie Exotique, Paris, v. 2, n. 6, ...
... cardiomyopathy among Trypanosoma cruzi-infected individuals". Molecular Immunology. 45 (1): 283-8. doi:10.1016/j.molimm.2007.04 ... "Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' ...
... dilated cardiomyopathies, Chagas, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and ...
Chagas' disease, and cardiomyopathies. Abnormal heart rhythms are often caused or worsened by medications such as digoxin, ...
His fields of research covered the biochemistry of parasitic cells in malaria and in Chagas disease-induced cardiomyopathy as ...
Council of Cardiomyopathies and Chagas Disease Council of Electrocardiography and Electrophysiology Alliance Against Sudden ...
... chagas disease MeSH C03.752.700.500.935.200.190 --- chagas cardiomyopathy MeSH C03.752.700.500.935.226 --- dourine MeSH C03.752 ...
Autonomic disease imparted by Chagas may eventually result in megaesophagus, megacolon and accelerated dilated cardiomyopathy. ... Chagas disease at Curlie (based on DMOZ) Chagas information at the U.S. Centers for Disease Control Chagas information from the ... If left untreated, Chagas disease can be fatal, in most cases due to heart muscle damage. In Chagas-endemic areas, the main ... "Enfermedad de Chagas - Mazza" (in Spanish). Asociación Lucha Contra el Mal de Chagas. Archived from the original on 16 ...
Other causes include: Chagas disease, due to Trypanosoma cruzi. This is the most common infectious cause of dilated ... Cardiomyopathy - Stanford Children's Health Cardiomyopathy Association: Dilated cardiomyopathy Children's Cardiomyopathy ... Dilated cardiomyopathy occurs late in gestation or several weeks to months postpartum as a peripartum cardiomyopathy. It is ... "What Is Cardiomyopathy?". NHLBI. 22 June 2016. Retrieved 10 November 2017. "Types of Cardiomyopathy". NHLBI. 22 June 2016. ...
Chagas disease. *Cardiomyopathy: Dilated (Alcoholic), Hypertrophic, and Restrictive *Loeffler endocarditis. *Cardiac ...
... cardiomyopathy, hypertrophic, familial MeSH C14.280.238.160 --- cardiomyopathy, restrictive MeSH C14.280.238.190 --- chagas ... cardiomyopathy, alcoholic MeSH C14.280.238.070 --- cardiomyopathy, dilated MeSH C14.280.238.100 --- cardiomyopathy, ... cardiomyopathy, dilated MeSH C14.280.434.313 --- dyspnea, paroxysmal MeSH C14.280.434.482 --- edema, cardiac MeSH C14.280. ... cardiomyopathy, dilated MeSH C14.280.195.400 --- hypertrophy, left ventricular MeSH C14.280.195.410 --- hypertrophy, right ...
DR16 is associated with Chaga's cardiomyopathy, rheumatic heart disease, coronary artery ectasia, and chronic discoid lupus ... "MHC class I and class II genes in Mexican patients with Chagas disease". Hum Immunol. 65 (1): 60-5. doi:10.1016/j.humimm. ...
Specific kinds of dilated cardiomyopathy are listed below, and other causes include Chagas disease, chemotherapeutic agents (e. ... Nonischemic cardiomyopathy - Cardiomyopathy caused by something other than ischemia. Amyloid cardiomyopathy - Cardiomyopathy ... Takotsubo cardiomyopathy (Transient apical ballooning, stress-induced cardiomyopathy) - A type of dilated cardiomyopathy caused ... Alcoholic cardiomyopathy - A type of dilated cardiomyopathy caused by chronic abuse of alcohol and results from direct toxicity ...
Cardiomyopathy due to autoimmune dysregulation and production of autoantibodies has been seen in humans and reproduced in ... "The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet". Anais da Academia Brasileira ... While the exact pathophysiology of Chagas disease is not completely understood, some models have shown that an overstimulation ... "Levels of anti-M2 and anti-β1 autoantibodies do not correlate with the degree of heart dysfunction in Chagas' heart disease". ...
Myocarditis (Chagas disease) Cardiomyopathy: Dilated (Alcoholic) · Hypertrophic · Restrictive (Loeffler endocarditis, Cardiac ...
Hypertrophic cardiomyopathy is typically an inherited condition.[12] There are many techniques and tests used to diagnose an ... "Chagas Heart Failure in Patients from Latin America". Card Fail Rev. 2 (2): 90-94. doi:10.15420/cfr.2016:14:2. PMC 5490952 ... Dilated cardiomyopathy is the most common type of cardiomegaly. In this condition, the walls of the left and/or right ... Luk, A; Ahn, E; Soor, G S; Butany, J (2008-11-18). "Dilated cardiomyopathy: a review". Journal of Clinical Pathology. BMJ. 62 ( ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Tachycardia-induced. *Restrictive. *Loeffler endocarditis ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis ...
I43) Cardiomyopathy in diseases classified elsewhere. Other[edit]. *(I50) Heart failure *(I50.0) Congestive heart failure * ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis ...
Chagas disease. *Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis ...
... tachycardia-induced cardiomyopathy, infark miokardial. AF umumnya menyertai simtoma hipertiroidisme, tirotoksikosis, pembesaran ... Penyakit Chagas. *Kardiomiopati: Dilatasi (Alkoholik), Hipertrofi, dan Restriktif *Endokarditis Loeffler. *Amyloidosis jantung ...
Coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems, heart attack[1][2]. ... Ventricular tachycardia can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems, or a ... Ventricular tachycardia can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems (e.g., ... "Catheter ablation of ventricular tachycardia in ischaemic and non-ischaemic cardiomyopathy: where are we today? A clinical ...
Cardiomyopathies. Chagas Cardiomyopathy. Heart Diseases. Cardiovascular Diseases. Chagas Disease. Trypanosomiasis. Euglenozoa ... Chagas disease. Chagas Cardiomyopathy. Trypanosoma cruzi. Omega-3. Cytokines. Lipid profile. Nutritional assessment. ... Effects of Omega-3 Supplementation on the Cytokine and Lipid Profiles in Patients With Chronic Chagas Cardiomyopathy. The ... Chagas Cardiomyopathy Dietary Supplement: Omega-3 Dietary Supplement: Placebo Comparator Early Phase 1 ...
Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. Blood Gene Signatures of Chagas ... About 30% of infected patients will develop chronic Chagas cardiomyopathy (CCC), an inflammatory cardiomyopathy characterized ... Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects 7 million people in Latin American areas of ... NK/CD8+ T-cell cytotoxicity could play a role in determining Chagas disease progression. Understanding genes associated with ...
Heart failure or cardiomyopathy. *Taking certain medicines such as beta blockers, calcium channel blockers, digoxin, and ... Inflammatory conditions that can involve the heart such as rheumatic fever, pericarditis, Chagas disease, or myocarditis ... Inflammatory conditions that involve the heart (rheumatic fever, Chagas disease, pericarditis, myocarditis) ... Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) ...
Heart failure or cardiomyopathy. *Taking certain medicines such as beta blockers, calcium channel blockers, digoxin, and ... Inflammatory conditions that can involve the heart such as rheumatic fever, pericarditis, Chagas disease, or myocarditis ... Inflammatory conditions that involve the heart (rheumatic fever, Chagas disease, pericarditis, myocarditis) ...
... Fernando A. Botoni,1,2,3 Antonio Luiz P. Ribeiro,1,2 Carolina Coimbra Marinho,4 Marcia ... Therefore, the objective of this review is to describe the treatment of Chagas cardiomyopathy with emphasis on its ... Despite its importance, chronic chagas cardiomyopathy (CCC) pathophysiology is yet poorly understood, and independently of its ... Chagas disease (ChD), caused by the protozoa Trypanosoma cruzi (T. cruzi), was discovered and described by the Brazilian ...
... Minna M. D. Romano, Henrique T. Moreira, André ... In Chagas disease (CD), there is direct evidence from both basic and clinical research of profound structural RV abnormalities ...
Failure to Diagnose Chagas Cardiomyopathy including overlooked symptoms and complications for under-diagnosed medical ... Undiagnosed Complications of Chagas Cardiomyopathy. As part of Chagas Cardiomyopathy diagnosis, consider whether any of these ... is the failure to correctly diagnose Chagas Cardiomyopathy leading to a person remaining with undiagnosed Chagas Cardiomyopathy ... not necessarily specific to Chagas Cardiomyopathy: *Failure to Diagnose *Under-Diagnosed Diseases *How Common is Failure to ...
... will manifest Chagas cardiomyopathy (CC). Identification of reliable early indicators of CC risk would enable prioritization of ... f Circulating Serum Markers and QRS Scar Score in Chagas Cardiomyopathy * Eva H. Clark, Morgan A. Marks, Robert H. Gilman, ... Chagas cardiomyopathy in the context of the chronic disease transition. PLoS Negl Trop Dis 4: e688.[Crossref] ... Matrix metalloproteinases 2 and 9 as diagnostic markers in the progression to Chagas cardiomyopathy. Am Heart J 165: 558-566.[ ...
Temporal trends in the contribution of Chagas cardiomyopathy to mortality among patients with heart failure ... Temporal trends in the contribution of Chagas cardiomyopathy to mortality among patients with heart failure ... Temporal trends in the contribution of Chagas cardiomyopathy to mortality among patients with heart failure ...
Purpose of Review Chagas cardiomyopathy is an emerging form of non-ischemic cardiomyopathy in the USA. This review aims to ... Chagas cardiomyopathy is an emerging form of non-ischemic cardiomyopathy in the USA. This review aims to summarize current ... The incidence of Chagas cardiomyopathy is increasing in the USA, driven mainly by immigration from countries where Chagas ... Chagas cardiomyopathy Trypanosoma cruzi Myocarditis Trypanocidal therapy Heart transplantation Reactivation This article is ...
Abstract Spasm and thrombosis of the coronary microcirculation has been implicated in the pathogenesis of the cardiomyopathy of ... Chagas' disease. We demonstrate that increases in platelet adherence and aggregation accompany Trypanosoma cruzi infection ... support the hypothesis that heightened platelet reactivity and endothelial cell dysfunction are associated with acute Chagas& ... Enhanced Platelet Adherence and Aggregation in Chagas' Disease: A Potential Pathogenic Mechanism for Cardiomyopathy * ...
Pathology and Pathogenesis of Chagas Heart Disease.. Abstract Chagas heart disease is an inflammatory cardiomyopathy that ... More News: Allergy & Immunology , Cardiology , Cardiomyopathy , Chagas Disease , Genetics , Heart , Heart Disease , Parasitic ... Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by ... Mariana Caldas Waghabi TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling ...
We congratulate the authors for this comprehensive review of Chagas cardiomyopathy, which is one of the most important ... 1999) Time to first shock in implantable cardioverter defibrillator (ICD) patients with Chagas cardiomyopathy. Pacing Clin ... Catheter Ablation to Treat Sustained Ventricular Tachycardia in Patients With Chagas Cardiomyopathy and Implantable ... Catheter Ablation to Treat Sustained Ventricular Tachycardia in Patients With Chagas Cardiomyopathy and Implantable ...
Heart failure due to Chagas cardiomyopathy is the main clinical presenation in Colombia. Heart failure due to Chagas disease ... Home » CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration ... CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled ... This study will allow us to explore the effect of beta-blockers in chagas cardiomyopathy. ...
Diagnostic Value of NT-proBNP for Early Identification of Chagas Cardiomyopathy in Non-endemic Areas. ...
Patients with chronic Chagas disease presented a negative correlation between left ventricular ejection fraction (LVEF) and the ... Samples from uninfected health individuals (CONT, n = 30) and patients with ischaemic cardiomyopathy (ISCH, n = 15) were used ... production and their possible association with different clinical forms of human chronic Chagas disease. METHODS IgG total and ... autoantibodies probably influences the left ventricular ejection fraction and could be related to chagasic cardiomyopathy. ...
Key words: Chagas disease, Chagas cardiomyopathy, Trypanosoma cruzi, electrocardiography, seroepidemiologic studies, Mexico. ... Chagas cardiomyopathy and serologic testing in a small rural hospital in Chiapas, Mexico ... Suggested citation Capps L, Abad B. Chagas cardiomyopathy and serologic testing in a small rural hospital in Chiapas, Mexico. ... Chagas cardiomyopathy and serologic testing in a small rural hospital in Chiapas, Mexico ...
Diagnostic Tests for Chagas Cardiomyopathy including blood tests, urine tests, swabs, diagnostic tests, lab tests, and ... Symptoms of Chagas Cardiomyopathy *Home Diagnostic Testing *Complications Home Diagnostic Testing. These home medical tests may ... be relevant to Chagas Cardiomyopathy: *High Blood Pressure: Home Testing *Home Blood Pressure Hypertension Tests *Home Blood ... Diagnostic Tests for Chagas Cardiomyopathy. *Home Diagnostic Testing for Chagas Cardiomyopathy. *Signs of Chagas Cardiomyopathy ...
Patients with Chagas cardiomyopathy who had a previous CMR evaluation were included, and clinical follow-up was retrospectively ... MF is an independent predictor of adverse outcome in Chagas cardiomyopathy. Our data may support the use of CMR in better risk- ... Myocardial fibrosis (MF) according to cardiac magnetic resonance (CMR) is a frequent finding in Chagas cardiomyopathy and has ... Long-Term Prognostic Value of Myocardial Fibrosis in Patients With Chagas Cardiomyopathy. ...
Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies. Juan D. Maya, Michel Lapier, Christian Castillo, ... Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies. Juan D. Maya, Michel Lapier, Christian Castillo, ... Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies Message Subject (Your Name) has forwarded a page ... Chagas cardiomyopathy presents several vascular characteristics that are similar to those presented in other acquired ...
Immunopathology of cardiomyopathy in the experimental Chagas disease Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. ... Immunopathology of cardiomyopathy in the experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94 ... Immunopathology of cardiomyopathy in the experimental Chagas disease. by: Soares, Milena Botelho Pereira Published: (1999) ... Immunopathology of Chagas disease by: Andrade, Zilton de Araújo Published: (1999) * Immunopathology of Chagas disease by: ...
Cardiomyopathy, Chagas; Trypanosomiasis, Cardiovascular; Myocarditis, Chagas. On-line free medical diagnosis assistant. Ranked ... We suspected chronic Chagas heart disease, i.e., dilated cardiomyopathy with apical ventricular aneurysm, right bundle branch ... A 56-year-old man underwent orthotopic heart transplantation because of end-stage Chagas cardiomyopathy. One hundred and ten ... Reactivation of cardiac Chagas disease in acquired immune deficiency syndrome. We report the case of a 29-year-old man who ...
chronic Chagas cardiomyopathy. CPC. cardiac progenitor cell. DAB. [1,1′-biphenyl]-3,3′,4,4′-tetramine. ECG. electrocardiogram. ... In chronic Chagas cardiomyopathy, T. cruzi burden is so low that it is difficult to detect by optical microscopy (Fig. 3A). ... Chronic Chagas Cardiomyopathy Mouse Model.. We used the mouse model of CCC described earlier by the Ribeiro-dos Santos group ( ... 2017) Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment. J Am Coll Cardiol 70:1510-1524. ...
Chagas cardiomyopathy is a complication of Chagas disease that presents in the cardiac form, which involves the manifestation ... Nursing Diagnostics in the Chagas Cardiomyopathy Carrier: Integrative Literature Review. Authors: Sardinha, Daniele Melo. Da ... Nursing Diagnostics in the Chagas Cardiomyopathy Carrier: Integrative Literature Review. Cardiology and Angiology: An ... Chagasic Cardiomyopathy; Nursing Diagnosis; Nursing Care. Data were analyzed by tabulation. Three articles were sought for the ...
... but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to ... Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy Deborah Elzita do Carmo Corrêa 1 , ... Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy Deborah Elzita do Carmo Corrêa et al ... but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to ...
  • Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. (bvsalud.org)
  • We performed laboratory tests ELISA and indirect hemagglutination in three groups of individuals 1) asymptomatic voluntary blood donors , 2) patients hospitalized in the cardiology department and 3) patients with dilated cardiomyopathy . (bvsalud.org)
  • We are trying to understand why some dogs remain asymptomatic, while others develop Chagas cardiomyopathy. (healthday.com)
  • Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. (bvsalud.org)
  • Improved left ventricular contraction and energetics in a patient with Chagas' disease undergoing partial left ventriculectomy. (lookfordiagnosis.com)
  • A 43-year-old patient with heart failure , precluded from heart transplantation or dynamic cardiomyoplasty because of Chagas' disease cardiomyopathy, mitral regurgitation, and ventricular mural thrombi, underwent mitral valvuloplasty and partial left ventriculectomy (PLV) between the papillary muscles . (lookfordiagnosis.com)
  • Radiofrequency ablation of sustained ventricular tachycardia related to the mitral isthmus in Chagas' disease. (lookfordiagnosis.com)
  • This case report describes the electrophysiological findings of a 62-year-old patient with chronic Chagas' disease and two distinct morphologies of sustained ventricular tachycardia that involved a mitral isthmus. (lookfordiagnosis.com)
  • Doppler echocardiogram is a noninvasive heart assessment method, and various morphological and functional analyses of patients with Chagas disease have demonstrated the usefulness of M mode 11 and 2-D in analyzing global and segmental contractility of the ventricles as well as systolic and diastolic left and right ventricular function and detecting thrombi and aneurysms 12 , 13 . (scielo.br)
  • Hisayoshi Suma and his colleagues at the Hayama Heart Center have performed left ventriculoplasty in 238 patients over the last 5 years, including 138 patients with left ventricular (LV) dysfunction caused by coronary artery disease (CAD) and 100 patients with non-ischemic cardiomyopathy, mostly idiopathic dilated cardiomyopathy. (wikipedia.org)
  • In spite of having detected autochthonous cases of Chagas disease , its importance to local public health remains to be established as well as the details of the dynamics of transmission so that the study is still in progress. (bvsalud.org)
  • Locally acquired cases of Chagas disease are exceedingly rare in the United States. (cdc.gov)
  • Although the insect vector for the parasite T. cruzi , triatomines (commonly known as "kissing bugs"), has been identified previously in Missouri, no locally acquired human cases of Chagas disease have been identified in the state. (cdc.gov)
  • Certain species of the kissing bug are well adapted to living with humans and it is thought that most cases of Chagas disease are spread from human to human by these insects. (verywellhealth.com)
  • Although this Chagas cohort is the largest examined by GWAS to date, (580 subjects), moderate sample size may explain in part the limited number of significant SNP variants. (cdc.gov)
  • Population stratification of Brazilian Chagas cohort along with Hapmap populations. (cdc.gov)
  • It is estimated that 6.6 million people, mostly in Mexico , Central America and South America , have Chagas disease as of 2015. (wikipedia.org)
  • Previously seen only in Mexico, Central America and South America, Chagas is now appearing in the United States, infecting humans and dogs. (healthday.com)
  • Samples were collected from 499 T. cruzi seropositive blood donors who had donated between 1996 and 2002, and 101 patients with clinically diagnosed Chagas cardiomyopathy. (cdc.gov)
  • The patients selected for group I (n = 31) were without previous pathologies, blood donors, and with normal results for electrocardiogram (ECG), hemoglobin (HB), creatinine (CT), thyroid-stimulating hormone (TSH), and glucose (G) levels as well as nonreactive indirect immunofluorescence serology (IgG IFI) 17 for Chagas disease. (scielo.br)
  • The main methods for controlling Chagas' disease are improvement of social and living conditions of the people, disinsectization, and destruction of infected animals. (thefreedictionary.com)
  • In 2009, a 51-year-old patient from Bolivia with a history of chronic Chagas disease, exhibiting severe organ involvement (chronic cardiomyopathy Kuschnir III and megacolon and megaesophagus degree IV) ( 5 ), was admitted to the International Health Department (Hospital Clinic, Barcelona). (cdc.gov)
  • Herein, we report the first case in Colombia of chagasic megacolon with cardiomyopathy associated with the T. cruzi I lineage. (ebscohost.com)
  • On December 13, 2017, the Missouri Department of Health and Senior Services (MDHSS) was notified of a suspected case of Chagas disease in a Missouri woman. (cdc.gov)