No data available that match "cevanes"


Effects of Veratrum nigrum alkaloids on central catecholaminergic neurons of renal hypertensive rats. (1/8)

AIM: To study the central hypotensive mechanism of Veratrum nigrum L var ussurience Nakai alkaloids (VnA) in renal hypertensive rats(RHR). METHODS: The quantitative method of immunocytochemistry (ICC) was used to observe and detect the effect of VnA (30 micrograms.kg-1, i.v.) on activity of central catecholaminergic (CA) neurons of C1, C2, A1, and A5 areas in RHR. RESULTS: VnA increased the immunoreactivity (IR) of tyrosine 3-monooxygenase (TM)-immunopositive (IP) neurons of C1, C2, and A5 areas in RHR experimental group compared with RHR control group [positive units: (1.9 +/- 0.4), (1.18 +/- 0.23), (1.2 +/- 0.4) vs (0.15 +/- 0.22), (0.31 +/- 0.16), (0.69 +/- 0.20), respectively]; IR of TM-IP neurons of C1 and C2 areas in RHR control group was decreased compared with sham-operated group [positive units: (0.15 +/- 0.22), (0.31 +/- 0.16) vs (1.45 +/- 0.29), (1.36 +/- 0.25), respectively]. CONCLUSION: VnA increased the activity of central CA neurons in RHR to exert its hypotensive effect.  (+info)

Differentiation-inducing effects of verticinone, an isosteroidal alkaloid isolated from the bulbus of Fritillaria ussuriensis, on human promyelocytic leukemia HL-60 cells. (2/8)

The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA.  (+info)

Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent. (3/8)

AIM: To seek a novel and potent antitussive drug based on Shedan-Chuanbei powder, a complex of traditional Chinese medicine preparation for cough therapy. METHODS: Verticinone-cholic acid (Ver-CA) salt, a novel, salifying derivative of verticinone and cholic acid, both of which are the major bioactive components in Shedan-Chuanbei powder, was synthesized. We then evaluated the antitussive activity and the acute toxicity of the salt. RESULTS: The new compound, with good solubility in water, has much more potent antitussive activity in comparison with the same dose of single verticinone and single cholic acid. The administration 3 mg/kg of Ver-CA could result in over 50% reduction of a citric acid-induced cough. Pretreatment with naloxone (0.8 mg/kg, ip) can only partially antagonize its antitussive effect. On the other hand, glybenclamide (3 mg/kg, ip), an ATP-sensitive K+ channel blocker, can also significantly reduce the antitussive effect of Ver-CA. A further acute toxicity study showed that the LD(50) values of Ver-CA were 3 times that of verticinone. CONCLUSION: Based on the studies of pharmacology and acute toxicity, the salt has a synergic and attenuated toxicity compared with single verticinone and cholic acid. Moreover, the present study also suggests that Ver-CA, a potential novel antitussive agent, may exert its antitussive effect via both the peripheral (modulated by ATP-sensitive K+ channels) and central mechanisms (modulated by the opioid receptor).  (+info)

Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor. (4/8)

 (+info)

Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain. (5/8)

Verticinone, an isosteroidal alkaloid separated from Bulbus Fritillaria (Chinese name "Bei-mu"), was evaluated for its analgesic activities in murine models of inflammatory and neuropathic pain. It was shown that oral administarion of verticinone could significantly inhibit acetic acid-induced writhing response in a dose-dependent way, and the writhing inhibition of 3 mg/kg verticinone was 66.2%, which was approximately higher than that of 200 mg/kg aspirin. In the formalin test, a high dose of (3 mg/kg) verticinone could inhibit the nociceptive response of both phases, but the lower dose (1.5 mg/kg) could only inhibit the second phase response, which suggested that verticinone might exert its analgesic effect through both central and peripheral mechanisms. In addition, in formalin and acetic acid tests, the spontaneous locomotive activities of the mice treated with verticinone were transiently greatly decreased when compared with the vehicle group. In the rat model of paclitaxel induced neuropathic pain, in contrast to the declined analgesic effect of morphine after repeated administration with the same dose, a relatively constant analgesic effect of verticinone was observed. These investigations suggested that verticinone could exert a good antinociceptive effect on inflammatory pain and cancer-related neuropathic pain probably through both peripheral and central mechanisms, and it might be partly involved with some sedation effects. Verticinone is expected to become a potentially novel sedative-analgesic agent without producing tolerance and dependence, but further studies are still urgently needed to elucidate the precise mechanisms and activities of it.  (+info)

Tetrodotoxin block of single germitrine-activated sodium channels in cultured rat cardiac cells. (6/8)

1. The open time of single Na+ channels in excised (outside-out) patches from cultured late-fetal rat ventricular myocytes was prolonged to several minutes by germitrine (0.5 mM) in order to analyse tetrodotoxin (TTX) blocking kinetics. 2. The germitrine modification appeared during depolarizing pulses that activated normal Na+ channels. Following repolarization to -100 mV, the modified Na+ channel remained activated for 136 +/- 186 s (mean +/- S.D., n = 54) with an open-channel current amplitude of -0.5 pA. The predominant open state with a mean open time of 0.13 s was interrupted by brief closing events lasting for milliseconds. Replacing extracellular Na+ by Cs+ decreased the current amplitude to -0.1 pA. 3. Extracellular superfusion with TTX (3 x 10(-7) M) of a single germitrine-activated Na+ channel induced full channel closures lasting seconds (blocked events) separated by channel reopenings (unblocked events) that were indistinguishable in terms of amplitude and gating kinetics from the germitrine-activated state in the absence of TTX. 4. Cumulative probability histograms of blocked and unblocked events (n greater than 140) collected during long-lasting germitrine modifications at 10(-7) and 3 x 10(-7) M-TTX are well described by single exponentials. The 3-fold increase in [TTX] decreased the time constant of the unblocked state, tau o, from 11.9 to 4.7 s, while the time constant of the blocked state, tau c, was not significantly altered from 8.6 to 9.7 s. A microscopic association rate constant of 7.7 x 10(5) M-1 s-1, dissociation rate constant of 0.11 s-1, and equilibrium dissociation constant of 1.4 x 10(-7) M (at -100 mV) were calculated (20 degrees C). 5. Increasing [TTX] to 10(-5) M decreased tau o to 86 ms. This argues against the existence of a slower conformational step interposed between the binding of TTX to an open channel and the resultant channel closure. 6. Setting the membrane potential to -50 or 0 mV subsequent to a germitrine modification at -100 mV did not significantly alter TTX (3 x 10(-7) M) blocking kinetics: tau o was 6.7 s at -50 mV and 5.2 s at 0 mV; tau c was 8.9 and 8.1 s, respectively. 7. These results suggest that blocked events correspond to the random times that a TTX molecule resides on the Na+ channel before it dissociates, and unblocked events correspond to the random waiting times of an unoccupied channel before it binds another toxin molecule.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Reversal of dantrolene sodium-induced depression of skeletal muscle in the cat. (7/8)

Dantrolene sodium, a muscle relaxant, does not have a clinically useful antagonist. The present study was undertaken to test the efficacies of germine monoacetate, 4-aminopyridine, neostigmine, and calcium chloride as possible agents for the reversal of the direct skeletal muscle depression produced by dantrolene sodium in the cat anesthetized with alpha-chloralose. Depression of the indirectly elicited twitch responses (0.1 Hz) of the tibialis anterior muscle by 25, 50, 75 and 84 per cent was produced by dantrolene, 0.16, 0.36, 0.88 and 1.13 mg/kg respectively; spontaneous recovery of twitch tension during the subsequent 30 min was negligible. After the 30-min observation period had elapsed, one of the reversal agents under study was given (iv) in divided doses at intervals of 10 min (five cats for each agent). Germine monoacetate (2 X 0.5 mg/kg) immediately reversed the dantrolene-induced twitch depression, with an over-shoot that persisted for an hour. 4-Aminopyridine (4 X 0.5 mg/kg) caused a steady but incomplete reversal to 17 per cent depression, 30 min after the last dose. Neostigmine (4 X 0.04 mg/kg) caused an immediate, but transient, reversal of the twitch depression, with overshoot. Calcium chloride (4 X 10 mg/kg) was without effect. It is concluded that germine monoacetate is the drug of choice for reversal of the muscle depression produced by dantrolene sodium in the cat.  (+info)

Sarcolemmal sodium permeability and contractile force of guinea pig papillary muscle: effects of germitrine. (8/8)

The action potential of guinea pig papillary muscle exposed to the ceveratrum alkaloid germitrine (2 mugM) is followed by a long-lasting after-depolarization (maximal amplitude, 8 mV; half-time of decay, 32 seconds; total duration, approximately 75 seconds). This after-depolarization interrupts the terminal phase of repolarization. During repetitive stimulation (0.1-1.0 Hz; 80 nM germitrine) the after-depolarizations that follow consecutive action potentials are summed, causing persistent depolarization of up to 10 mV. The after-depolarization is reversibly abolished by tetrodotoxin (TTX). Test contractions evoked at various times during or after the germitrine-induced after-depolarization reveal a phase during which the ability of the muscle to develop force is transiently increased. This positive inotropic influence reaches its maximum 1 minute after the conditioning stimulus and thereafter decays with a half-time 4.8 times longer than the half-time of decay of the after depolarization. It is reversibly abolished by TTX and augmented by dihydro-ouabain (DHO). We conclude: Germitrine induces an after-depolarization by prolonging dramatically the Na permeability component which is mediated by the fast Na channels and normally restricted to the first few milliseconds of the action potential. The germitrine-induced selective and persistent increase of sarcolemmal sodium permeability (PNA) causes a positive inotropic effect, probably because intracellularly accumulating Na ions exchange for extracellular Ca ions.  (+info)

*List of MeSH codes (D03)

... cevanes MeSH D03.132.920.256.310 --- germine acetates MeSH D03.132.920.256.543 --- protoveratrines MeSH D03.132.920.256.815 ...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Bulb: 1.5 cm in diameter, ovoid, without bulbils or stolons. Stem: 15-51 cm, 12-3-(-45) cm above ground, smooth. Leaves: 4-7, somewhat glaucous, all alternate, the lowest 5-11 × 1.5-2 cm, narrowly oblanceolate to elliptic-oblong, usually folded at fruiting time; bract leaves 2-5 cm long, linear to narrowly lanceolate, acute. Flowers: 1-2, narrowly campanulate; perianth segments purplish outside, paler inside with median yellowish-green bands extending to apices, sometimes tinged or sparsely green-dotted towards margins, outer segments 12 × 16-46 mm, elliptic-narrowly oblong, obtuse, inner segments 6.5-8 mm wide, lanceolate obtuse. Nectaries: broadly lanceolate to narrowly elliptic, 2.5-4 mm long placed 0.5-1 mm above base of tepals, green. Filaments: 7-8 mm, yellow-brown, stout, glabrous to sparsely papillose at base, densely papillose in upper part; anthers 5-7 mm long before dehiscence, ellipsoid, brown-purplish, basifixed. Style: 6-8 mm, entire, stout, greenish-yellow, densely papillose. ...
Flower generally bisexual, generally radial; perianth often showy, segments generally 6 in two petal-like whorls (outer sometimes sepal-like), free or fused at base; stamens 6 (or 3 + generally 3 ± petal-like staminodes), filaments sometimes attached to perianth or fused into a tube or crown; ovary superior or inferior, chambers 3, placentas generally axile, style generally 1, stigmas generally ...
The nuclear cycle in plants and animals consists in the alternation of two mechanically stable systems, the resting nucleus and the metaphase chromosomes. The regularity of this alternation and the constancy of the bodies taking part in it has led to the assumption that it depends on a "permanence" of the positional relationship of essential elements in these bodies, that is, on a property of passing on the same structure from mother to daughter nucleus and from mother to daughter organism by the structure reproducing its like without change. This assumption has been vindicated by the demonstration at a particular nuclear division, meiosis, in the transitional and generally unstable stages of prophase between the resting nucleus and the metaphase chromosomes, of a linear arrangement of particles which is constant both in individuals and in races. The inference of this constant arrangement of particles depends on evidence of form and of function. When the inference is from form the particles are ...
While we have our share of daffodils, tulips, hyacinths and the like, there is also an attraction here to the little oddballs of the bulb world, the Fritillaria ssp. Fritillaria is a genus in the Liliaceae family distributed throughout Europe and North Africa (especially around the Mediterranean), temperate Asia and North America. Most of them…
Looking for online definition of bulbus olfactorius in the Medical Dictionary? bulbus olfactorius explanation free. What is bulbus olfactorius? Meaning of bulbus olfactorius medical term. What does bulbus olfactorius mean?
There is so much going on in the garden now, that it really needs a number of instalments. Much as the woodland plants look their best when allowed to merge and self-seed together, bulbs look stunning when combined in one area in the garden - the ultimate example is the amazing bulb-walk at Sissinghurst which was and is created over decades of careful addition and subtraction, and includes no-bulbous plants like pulsatillas, primroses, euphorbias and a few others. At its height in spring I dont think there can be a planting to compare with it anywhere, and it would be true to say that it is a work of art. This is all by way of preamble for our relatively feeble attempt to make something similar in a small circular bed in the middle of the lawn. Maybe in 20 years time... None the less there are some very nice plants flowering - Fritillaria kotschyana came from Kath Dryden and is steadily building up; the second picture shows it at the bottom, before the tulips have really got going. What the bed ...
0047]Cardiac cells isolated from normal (N) or failing (F) hearts were subjected to trains of depolarizations to assess the main mechanisms of Ca2+-induced Ca2+ release (CICR), i.e., trigger Ca2+ entry through L-type Ca2+ channels (ICa,L), the rate of rise (ΔCa/Δt) and amplitude (ΔCa) of the [Ca2+]i transient, and the SR Ca2+ load (CaSR, measured as the integral of NCX current during caffeine application [Hobai, 2000 #371; FIG. 2). The experimental protocol consisted of a train of 0.5 sec depolarizations from -80 mV to +10 mV, applied at 0.5 Hz until steady-state, followed by a rapid application of caffeine, to measure SR Ca2+ load. Myocytes from failing hearts cells showed the characteristic Ca2+ handling deficit, with depressed [Ca2+]i transients and CaSR, and a normal ICa,L (FIGS. 2-3). Internal equilibration with 10 μM XIP induced a large increase in the steady-state CaSR and [Ca2+]i transients, in the absence of any change in ICa,L. FIG. 2 shows the XIP effects on Ca2-induced Ca2+ ...
These images exist as archived TIFF images and one or more JPEG versions for general use. They were scanned at 2710 dpi, 24-bit from the original using an Nikon CoolScan V ED scanner, default color configuration ...
Fritillaria poluninii is a much less imposing miniature from north-eastern Iraq and just across the border into Iran, though one with a great attraction for the enthusiast. Cyril Lafongs example of this diminutive species was grown from his own seed sown in 1996 and subsequently given his standard bulb treatment, i.e. a rich gritty compost with plenty of water (including an occasional half-strength high potash feed) while the plants are in growth with, then dryish following their early summer return to dormancy. The species was discovered by Oleg Polunin during his Iraq expedition of 1958 and originally classified as a subspecies of Fritillaria crassifolia: this view was maintained when it was subsequently found in Irans Kordestan Province by Per Wendelbo 20 years later. Now generally accepted as a distinct species on account of its narrow, glossy green leaves, its short stems and the one or two (rarely three) whitish, green-veined bells each supports, some publications (including the AGS ...
I bergamaschi Veratrum sono ormai amici di vecchia data: li abbiamo ospitati su queste pagine (ma anche in sede di intervista radiofonica) in occasione del demo cd Sangue e successivamente per il debut album Sentieri Dimenticati. Dopo una chiacchierata face to face prenatalizia e lascolto di alcune tracce del nuovo disco, eccomi qui a parlare più dettagliatamente di Mondi Sospesi, il secondo lavoro sulla lunga distanza, per il terzetto guidato da Haiwas. Ancora una volta vorrei partire elogiando lartwork estremamente curato e suggestivo, un artwork che cela misteri, simboli e profezie qui espressi palesemente dalla torre di Babele che cappeggia nella parte destra della cover. Passando alla musica, qualche novità rispetto al passato è riscontrabile nei contenuti di Mondi Sospesi, ma andiamo con ordine e partiamo da quelle che sono le certezze dei nostri. Si parte con lassalto sonoro di "Un Canto", che ricorda, qualora ce ne fosse bisogno, di che pasta sono fatti i nostri: ritmiche ...
Julian P. Meeks is the author of this article in the Journal of Visualized Experiments: Ex Vivo Bereidingen van de Intact Vomeronasal en accessoires bulbus olfactorius
The genus Nomocharis includes bulbous plants with high ornamental value. It is inextricably linked with the genera Lilium and Fritillaria in evolution. Nomocharis is distributed in the Hengduan Mountains of the Qinghai-Tibetan Plateau, including high-altitude areas in Yunnan, Sichuan and Tibet, China. Plants usually grow on the edge of forests or sunny alpine slopes. There are nine species in the genus, and, besides Nomocharis synaptica, the other eight species are distributed in China. Through intensive investigation on Nomocharis in recent years, a new species named Nomocharis gongshanensis has been discovered in Gongshan county of Yunnan province. The typical morphological characteristics of Nomocharis are as follows: widely opened perianth or perigonium and saucer-shaped flower; dark blotches in the bases of tepals, a series of thin tissue flanges standing erect and flabellately on both sides of the basal channel or nectaries of inner tepals, but not on outer tepals; fleshy, cylindrical or ...
Also known as devils dung, stinking gum, food of the gods, and giant fennel, hing has a varied and suprising diversity of uses. Along the Tex-Mex border hing was used for wolf bait. The odor attracts wolves. In Jamaica, hing is used to protect the ...
Veratrum Album 30C by Boiron 30696077513. We carry every Boiron product at discount prices. 80 Pellet 23% off, $5.14. Over 500 brands, 30000 products at discount prices 20-70% off.
Aftercontractions, delayed afterdepolarizations, and automaticity occurred in guinea pig papillary muscles that were reoxygenated after hypoxic conditioning. The emergence of dysfunction was dependent on the severity of hypoxic conditioning and on stimulation during reoxygenation. After 60 minutes of substrate-free hypoxia, reoxygenation induced automaticity in a high proportion of stimulated muscles; the automaticity appeared within 1 minute and lasted for 10-20 minutes. After similar conditioning, muscles reoxygenated for 7-15 minutes were stimulated at various cycle lengths. The incidence of automaticity and the amplitudes of delayed events had W-shaped dependencies on cycle length (200-1,000 msec), whereas coupling intervals had M-shaped dependencies. In ventricular myocytes that displayed automaticity after reoxygenation, extrasystolic upstrokes arose smoothly from delayed afterdepolarizations that reached threshold. In tissue, extrasystolic upstrokes usually rose sharply from delayed ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
RESEPTOR dan PENGINDERAAN Reseptor : struktur yang menerima stimulus/rangsangan. Terbagi atas : Eksteroreseptor Reseptor yang menerima rangsang/impuls dari luar tubuh. Umum/biasa : suhu, tekanan. Khusus : reseptor indera pengelihatan : retina penghidu : bulbus olfactorius pengecap : gema gustatoria Pendengaran : cocchlea Taktil : paccini, meissner
Robin Bennett 08. Rønsted, N., Law, S., Thornton, H., Fay, M. F. & Chase M. W. (2005). Molecular phylogenetic evidence for the monophyly of Fritillaria and Lilium (Liliaceae; Liliales) and the infrageneric classification of Fritillaria. Molecular Phylogenetics and Evolution, 35: 509-527. Fay, M. F., Qamaruz-Zaman, F., Cowan, R. S. & Thornton, H. (2002). Molecular techniques for orchid conservation genetic studies. In J. Clark, W. M. Elliott, G. Tingley & J. Biro (eds.) Proceedings of the 16th World Orchid Conference, Vancouver Orchid Society, Vancouver. 152-157.. Ingrouille, M. J., Bowman, D., Fay, M. F., van der Bank, M. & Chase, M. W. (2002). Systematics of Vitaceae from the viewpoint of plastid rbcL DNA sequence data. Botanical Journal of the Linnean Society, 138: 421-432.. Maunder, M., Cowan, R. S., Stranc, P. & Fay, M. F. (2001). The genetic status and conservation management of two cultivated bulb species extinct in the wild:Tecophilaea cyanocrocus (Chile) and Tulipa sprengeri (Turkey). ...
Specially, Veratrum Album medicine is used in the symptom of sweating on the forehead. Homeopathic remedy, Potencies of Veratrum Album Medicine
Feulgen bands can be obtained at the sites of constitutive heterochromatin in the chromosomes of Anemone blanda, Fritillaria lanceolata and Scilla siberica, simply by means of a short or extended acid hydrolysis. Extended hydrolysis gives positive bands in A. blanda and F. lanceolata and negative bands in S. siberica. Short hydrolysis gives no bands in A. blanda and S. siberica but gives negative bands in F. lanceolata. The kind of Feulgen banding obtained is not correlated with the type of base richness of the heterochromatin DNA; rather, it is probably due to differences in the associated nucleoproteins. ...

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Alkaloids, isolation & purification, Cevanes, Drugs, Chinese Herbal, chemistry, Homosteroids, Steroids MEDLINE®/PubMed® ...
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List of MeSH codes (D03) - WikipediaList of MeSH codes (D03) - Wikipedia

... cevanes MeSH D03.132.920.256.310 --- germine acetates MeSH D03.132.920.256.543 --- protoveratrines MeSH D03.132.920.256.815 ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)

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Alkaloids, analysis, Cevanes, Chromatography, Thin Layer, Densitometry, Drugs, Chinese Herbal, chemistry, classification, ...
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Cevanes | Profiles RNSCevanes | Profiles RNS

"Cevanes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject Headings) ... This graph shows the total number of publications written about "Cevanes" by people in this website by year, and whether " ... Below are the most recent publications written about "Cevanes" by people in Profiles. ...
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DeCS Ingl s+escopoDeCS Ingl s+escopo

D03.633.400.256 Cevanes .. D03.633.400.256.310 Germine Acetates .. D08 Enzymes and Coenzymes .. D08.811 Enzymes .. D08.811.913 ... D03.132.920.256 Cevanes .. D03.132.920.256.310 Germine Acetates .. D03.633 Heterocyclic Compounds, Fused-Ring .. D03.633.400 ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Acetates

Web Site Index: cetsafehouse-ha.com ... ceventa.comWeb Site Index: cetsafehouse-ha.com ... ceventa.com

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