A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the UTERINE CERVIX.
The examination, therapy or surgery of the cervix and vagina by means of a specially designed endoscope introduced vaginally.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.
Division of tissues by a high-frequency current applied locally with a metal instrument or needle. (Stedman, 25th ed)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
The excision of a cone of tissue, especially of the CERVIX UTERI.
Cytological preparation of cells collected from a mucosal surface and stained with Papanicolaou stain.
A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.
A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.
A genus of DNA viruses in the family PAPILLOMAVIRIDAE. They preferentially infect the anogenital and ORAL MUCOSA in humans and primates, causing both malignant and benign neoplasms. Cutaneous lesions are also seen.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumors or cancer of the VAGINA.
Tumors or cancer of the VULVA.
Sexually transmitted form of anogenital warty growth caused by the human papillomaviruses.
DNA probes specific for the identification of human papilloma virus.
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
Disappearance of a neoplasm or neoplastic state without the intervention of therapy.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Pathological processes of the UTERINE CERVIX.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Tumors or cancer of the ANAL CANAL.
A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
Methods used to study CELLS.
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.
The sorting out and classification of patients or casualties to determine priority of need and proper place of treatment.
Methods for detecting or typing the DNA of an ALPHAPAPILLOMAVIRUS in biological tissues and fluids.
Excision of the uterus.
A type I keratin found associated with KERATIN-6 in rapidly proliferating squamous epithelial tissue. Mutations in the gene for keratin-17 have been associated with PACHYONYCHIA CONGENITA, TYPE 2.
A type of ALPHAPAPILLOMAVIRUS associated with high risk for anogenital neoplasms.
Surgery performed on the pregnant woman for conditions associated with pregnancy, labor, or the puerperium. It does not include surgery of the newborn infant.
A malignant epithelial tumor with a glandular organization.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.
Tumors or cancer of the PROSTATE.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Inflammation of the UTERINE CERVIX.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
A form of therapy consisting in the local or general use of cold. The selective destruction of tissue by extreme cold or freezing is CRYOSURGERY. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Pathological processes involving the PENIS or its component tissues.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The co-occurrence of pregnancy and NEOPLASMS. The neoplastic disease may precede or follow FERTILIZATION.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Pathological processes of the VULVA.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A type of ALPHAPAPILLOMAVIRUS usually associated with GENITAL WARTS; and LARYNGEAL NEOPLASMS.
Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
DNA present in neoplastic tissue.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.
Diseases due to or propagated by sexual contact.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Sexual activities of humans.
A technique encompassing morphometry, densitometry, neural networks, and expert systems that has numerous clinical and research applications and is particularly useful in anatomic pathology for the study of malignant lesions. The most common current application of image cytometry is for DNA analysis, followed by quantitation of immunohistochemical staining.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Elements of limited time intervals, contributing to particular results or situations.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Married or single individuals who share sexual relations.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
A condition in which there is a change of one adult cell type to another similar adult cell type.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
A type of ALPHAPAPILLOMAVIRUS causing recurrent respiratory PAPILLOMATOSIS; GENITAL WARTS; and other neoplasms.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Proteins that form the CAPSID of VIRUSES.
A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Cancers or tumors of the PENIS or of its component tissues.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Tumors or cancer of the CONJUNCTIVA.

Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. (1/1426)

AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions.  (+info)

Screening for cervical cancer: a review of women's attitudes, knowledge, and behaviour. (2/1426)

The United Kingdom (UK) cervical screening programme has been successful in securing participation of a high proportion of targeted women, and has seen a fall in mortality rates of those suffering from cervical cancer. There remains, however, a significant proportion of unscreened women and, of women in whom an abnormality is detected, many will not attend for colposcopy. The present work reviews the psychological consequences of receiving an abnormal cervical smear result and of secondary screening and treatment, and examines reasons for women's non-participation in the screening programme. Psychological theories of screening behavior are used to elucidate women's reactions and to suggest methods of increasing participation, of improving the quality of the service, and of reducing women's anxiety. A literature search identified studies that examine factors influencing women's participation in the screening programme, their psychological reaction to the receipt of an abnormal cervical smear result, and experiences of colposcopy. Reasons for non-participation include administrative failures, unavailability of a female screener, inconvenient clinic times, lack of awareness of the test's indications and benefits, considering oneself not to be at risk of developing cervical cancer, and fear of embarrassment, pain, or the detection of cancer. The receipt of an abnormal result and referral for colposcopy cause high levels of distress owing to limited understanding of the meaning of the smear test; many women believe the test aims to detect existing cervical cancer. The quality of the cervical screening service can be enhanced by the provision of additional information, by improved quality of communication, and by consideration of women's health beliefs. This may result in increased participation in, and satisfaction with, the service.  (+info)

Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. (3/1426)

BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women's Interagency HIV Study to determine the prevalence of and risk factors for cervicovaginal HPV infection in HIV-positive women. METHODS: HIV-positive (n = 1778) and HIV-negative (n = 500) women were tested at enrollment for the presence of HPV DNA in a cervicovaginal lavage specimen. Blood samples were tested for HIV antibody status, level of CD4-positive T cells, and HIV RNA load (copies/mL). An interview detailing risk factors was conducted. Univariate and multivariate analyses were performed. RESULTS: Compared with HIV-negative women, HIV-positive women with a CD4+ cell count of less than 200/mm3 were at the highest risk of HPV infection, regardless of HIV RNA load (odds ratio [OR] = 10.13; 95% confidence interval [CI] = 7.32-14.04), followed by women with a CD4+ count greater than 200/mm3 and an HIV RNA load greater than 20,000 copies/mL (OR = 5.78; 95% CI = 4.17-8.08) and women with a CD4+ count greater than 200/mm3 and an HIV RNA load less than 20,000 copies/mL (OR = 3.12; 95% CI = 2.36-4.12), after adjustment for other factors. Other risk factors among HIV-positive women included racial/ethnic background (African-American versus Caucasian, OR = 1.64; 95% CI = 1.19-2.28), current smoking (yes versus no; OR = 1.55; 95% CI = 1.20-1.99), and younger age (age < 30 years versus > or = 40 years; OR = 1.75; 95% CI = 1.23-2.49). CONCLUSIONS: Although the strongest risk factors of HPV infection among HIV-positive women were indicators of more advanced HIV-related disease, other factors commonly found in studies of HIV-negative women, including racial/ethnic background, current smoking, and age, were important in HIV-positive women as well.  (+info)

Risk factors for abnormal anal cytology in young heterosexual women. (4/1426)

Although anal cancers are up to four times more common in women than men, little is known about the natural history of anal human papillomavirus (HPV) infections and HPV-related anal lesions in women. This study reports on the prevalence of and risks for anal cytological abnormalities over a 1-year period in a cohort of young women participating in a study of the natural history of cervical HPV infection. In addition to their regularly scheduled sexual behavior interviews and cervical testing, consenting women received anal HPV DNA and cytological testing. Anal cytology smears were obtained from 410 women whose mean age was 22.5 +/- 2.5 years at the onset of the study. Sixteen women (3.9%) were found to have abnormal anal cytology: 4 women had low-grade squamous intraepithelial lesions (SILs) or condyloma; and 12 women had atypical cells of undetermined significance. Factors found to be significantly associated with abnormal anal cytology were a history of anal sex [odds ratio (OR), 6.90; 95% confidence interval (CI), 1.7-47.2], a history of cervical SILs (OR, 4.13; 95% CI, 1.3-14.9), and a current anal HPV infection (OR, 12.28; 95% CI, 3.9-43.5). The strong association between anal intercourse and the development of HPV-induced SILs supports the role of sexual transmission of HPV in anal SILs. Young women who had engaged in anal intercourse or had a history of cervical SILs were found to be at highest risk.  (+info)

Sexual behaviour and papillomavirus exposure in cervical intraepithelial neoplasia: a population-based case-control study. (5/1426)

Sexual history is an established risk determinant for cervical neoplasia. It is not clear if human papillomavirus (HPV) exposure entirely explains the sexual behaviour-related risk or if other sexually transmitted agents may act as cofactors for HPV in carcinogenesis. The aim of this study was to elucidate whether HPV exposure or HPV persistence explains the sexual history-related risk of high-grade cervical intraepithelial neoplasia (CIN) using a population-based case-control study of most of the 254 women referred to colposcopy in the Vasterbotten county in Sweden because of an abnormal cervical smear during October 1993 to December 1995 and 320 age-matched women from the general population. The women were interviewed for sexual history and tested for presence of serum antibodies to HPV-16, -18 and -33 as well as for presence of HPV DNA in cervical brush samples. HPV-16, -18 and -33 seropositivity was specific for the corresponding type of HPV DNA, dependent on the lifetime sexual history and associated with a two- to threefold increased risk of CIN 3. There was no sexual history-related risk of CIN among HPV-seropositive women and adjustment for HPV DNA presence explained the sexual history-related risk of CIN. In conclusion, HPV exposure appeared to explain the sexual history-related risk of high-grade CIN.  (+info)

Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. (6/1426)

T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development.  (+info)

Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. II. Systemic but not local IgA responses correlate with clearance of HPV-16. (7/1426)

To investigate whether there is an association between local or systemic IgG and IgA responses against human papillomavirus (HPV) type 16 virus-like particles (VLP) containing L1 and L2 and the possible influence of these responses on clearance of HPV-16 and its associated lesions, cervical mucus samples from 125 patients and plasma samples from 100 patients, all participating in a non-intervention cohort study of women with abnormal cytology, were analysed. The results show that local IgG and IgA HPV-16 VLP-specific antibodies do not correlate with virus clearance. However, systemic IgG responses were more frequently detected in patients with a persistent infection (11/24) compared with patients with cleared HPV-16 infections (3/28, P = 0.006). Furthermore, the ultimate development of high-grade lesions was associated with systemic VLP-specific IgG reactivity (P = 0.026). By contrast, systemic IgA responses were correlated with virus clearance (7/28 clearance compared with 1/24 persistence patients, P = 0.06). This correlation was statistically significant when only those clearance patients who tested HPV-16 DNA-positive at more than one visit were included in the analysis (5/11 compared with 1/24, P = 0.007). As these systemic IgA responses were not accompanied by local IgA responses, the systemic IgA responses in HPV-16 clearance patients are suggested to be a by-product of a successful cellular immune response induced at the local lymph nodes, mediated by cytokines.  (+info)

Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type. (8/1426)

The association between human papillomavirus (HPV) DNA copy number and cervical disease was investigated. Viral DNA copy number for the most common high-risk HPV types in cervical cancer (types 16, 18, 31, and 45) was determined in cervical cytobrush specimens from 149 women with high-grade cervical intraepithelial neoplasias (CIN II-CIN III), 176 with low-grade CIN (CIN I), and 270 with normal cytology. Quantitative, PCR-based fluorescent assays for each of the HPV genotypes and for the beta-globin gene were used. The amount of cellular DNA increased significantly with increasing disease; thus, HPV was expressed as copies per microgram of cellular DNA. The assay had a dynamic range of >10(7), allowing documentation for the first time of the wide range of HPV copy numbers seen in clinical specimens. Median HPV DNA copy number varied by more than 10(4) among the viral types. HPV16 was present in the highest copy number; over 55% of HPV16-positive samples contained more than 10(8) copies/microgram. Median copy number for HPV16 showed dramatic increases with increasing epithelial abnormality, an effect not seen with the other HPV types. HPV16 increased from a median of 2.2 x 10(7) in patients with normal cytology, to 4.1 x 10(7) in CIN I patients, to 1.3 x 10(9) copies/microgram in CIN II-III patients. Even when stratified by cervical disease and viral type, the range of viral DNA copies per microgram of cellular DNA was quite large, precluding setting a clinically significant cutoff value for "high" copy numbers predictive of disease. This study suggests that the clinical usefulness of HPV quantitation requires reassessment and is assay dependent.  (+info)

Cervical intraepithelial neoplasia grade 2 or 3 was confirmed by biopsy in 28 women. On the basis of survival analysis, the cumulative incidence of cervical intraepithelial neoplasia at two years was 28 percent among women with a positive test for HPV and 3 percent among those without detectable HPV DNA. The risk was highest among those with HPV type 16 or 18 infection (adjusted relative risk as compared with that in women without HPV infection, 11; 95 percent confidence interval, 4.6 to 26; attributable risk, 52 percent). All 24 cases of cervical intraepithelial neoplasia grade 2 or 3 among HPV-positive women were detected within 24 months after the first positive test for HPV. After adjustment for the presence of HPV infection, the development of cervical intraepithelial neoplasia was also associated with younger age at first intercourse, the presence of serum antibodies to Chlamydia trachomatis, the presence of serum antibodies to cytomegalovirus, and cervical infection with Neisseria ...
TY - JOUR. T1 - Long-term cumulative incidence of cervical intraepithelial neoplasia grade 3 or worse after abnormal cytology. T2 - Impact of HIV infection. AU - Massad, L. Stewart. AU - Pierce, Christopher B.. AU - Minkoff, Howard. AU - Watts, D. Heather. AU - Darragh, Teresa M.. AU - Sanchez-Keeland, Lorraine. AU - Wright, Rodney L.. AU - Colie, Christine. AU - DSouza, Gypsyamber. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2014/4/15. Y1 - 2014/4/15. N2 - To estimate the long term cumulative risk for cervical intraepithelial neoplasia grade 3 or worse after an abnormal cervical Pap test and to assess the effect of HIV infection on that risk. Participants in the Womens Interagency HIV Study were followed semiannually for up to 10 years. Pap tests were categorized according to the 1991 Bethesda system. Colposcopy was prescribed within 6 months of any abnormality. Risk for biopsy-confirmed CIN3 or worse after abnormal cytology and at least 12 months follow-up was ...
Background: Cervical intraepithelial lesion is a precursor lesion for cancer of the cervix. It is usually asymptomatic and can only be detected through screening. Purpose: This study was designed to determine the prevalence, risk factors, and utilization of screening services for cervical intraepithelial neoplasia among the women. Methods: It was a cross-sectional study during an organized screening program for cervical intraepithelial neoplasia (CIN) using Pap smear among women in July 2013 at the University Teaching Hospital, North Central Nigeria. Results: Out of the 286 women interviewed, 208 agreed to be screened giving a response rate of 72.7%. Most (72.1%) of them were 31-50 years, 78.4% were married, and 65.4% had a tertiary level of education. Approximately, 77% became sexually active as teenagers. CIN 1 and CIN 2/3 accounted for 4.8% and 2.9%, respectively. Overall, low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion amounted to 7.7%. The risk of ...
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer form forming, growing, or coming back. Vaccines may help the body build an effective immune response against human papillomavirus and may be effective in preventing cervical intraepithelial neoplasia or cervical cancer. It is not yet known whether human papillomavirus vaccine is more effective than hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer.. PURPOSE: This randomized phase III trial is studying human papillomavirus vaccine to see how well it works compared to hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer in younger healthy participants. ...
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer form forming, growing, or coming back. Vaccines may help the body build an effective immune response against human papillomavirus and may be effective in preventing cervical intraepithelial neoplasia or cervical cancer. It is not yet known whether human papillomavirus vaccine is more effective than hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer.. PURPOSE: This randomized phase III trial is studying human papillomavirus vaccine to see how well it works compared to hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer in younger healthy participants. ...
Human papillomavirus antigen was found in 39 (16%) of 253 colposcopic biopsies from a group of women at high risk for cervical cancer who had been examined in the early 1970s. Immunohistochemical evidence of papillomavirus infection was found in 20 (30%) of 67 cervical intraepithelial neoplasia lesions infected with wart virus from these patients. When these results were compared with results of a similar study carried out in the early 1980s there was no significant difference in the prevalence of human papillomavirus antigen in cervical intraepithelial neoplasia lesions infected with wart virus from women who had been examined over a decade apart.. ...
Low grade squamous intraepithelial lesion (LSIL) - symptoms, causes and treatment. These are often a result of infections or by minor injuries undergoing
Thomas I., Wright G. and Ward B. (1990) The effect of condom use on cervical intraepithelial neoplasia grade I (CIN I). Australian and New Zealand Journal of Obstetrics and Gynaecology, 30 3: 236-239. ...
TY - JOUR. T1 - Age-related changes in pre- and post-conization HPV genotype distribution among women with high-grade cervical intraepithelial neoplasia. AU - Giannella, Luca. AU - Fodero, Cristina. AU - Boselli, Fausto. AU - Rubino, Teresa. AU - Mfuta, Kabala. AU - Prandi, Sonia. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Objective: To assess the effect of age on pre- and post-conization HPV genotype distribution. Methods: The present retrospective observational study included consecutive women with high-grade cervical intraepithelial neoplasia who underwent conization at the Cervical Cancer Screening Centre of Reggio Emilia, Italy, and University Hospital of Modena, Italy, between February 1, 2012, and October 31, 2014. Pre-conization and 6-month post-conization HPV genotyping results were compared between four age groups (,30, 30-39, 40-49, and ≥50 years) and age-related changes in the HPV genotypes present were evaluated. Results: There were 162 patients included. The lowest occurrence of ...
TY - JOUR. T1 - Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia. AU - Giannella, Luca. AU - Prandi, Sonia. AU - Giulini, Simone. AU - Mfuta, Kabala. AU - Torrini, Barbara. AU - Boselli, Fausto. PY - 2013/11. Y1 - 2013/11. N2 - Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ...
Description: Cervical Intraepithelial Neoplasia (CIN) - Pipeline Review, H1 2017, provides an overview of the Cervical Intraepithelial Neoplasia (CIN) (Wom
Source: Department of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Montebello.. Abstract:. A significant higher incidence of some cancers, especially lung cancer, has been found in women with previous HPV-related (human papillomavirus) urogenital and anal neoplasias than in individuals without this particular clinical history. The aim of our study was to investigate whether HPV is present in both CIN III (cervical intraepithelial neoplasia) lesions and bronchopulmonary second primary cancers in women with a clinical history of both diseases. Paraffin-embedded tumour tissue from 75 patients with bronchopulmonary carcinomas was examined using the polymerase chain reaction (PCR) technique and in situ hybridization for the presence of human HPV. In total, 51 primary tumours without metastases, 11 primary tumours with metastases and 13 lymph node metastases without available tissue from primary tumours were analysed. In our study 37/75 primary ...
AIM: To determine the frequency of cervical intraepithelial neoplasia (CIN) following large loop excision of the transformation zone of the cervix (LLETZ) according to grade and completeness of excision of CIN. METHODS: A retrospective study of 669 patients who had LLETZ biopsies showing CIN 1, 2, or 3. The patients were subdivided according to the grade and completeness of excision of CIN. The follow up period was 1.5 to 3.5 years. Risk of persistent/recurrent CIN was assessed by the frequency of histological diagnosis of CIN during the follow up period. RESULTS: Frequency of persistent/recurrent CIN increased with the grade of CIN reported: 6.7% of patients with CIN 1, 13.4% with CIN 2, and 21.7% with CIN 3 developed persistence or recurrence. The frequency of CIN persistence/recurrence was significantly lower where LLETZ showed complete excision of CIN (8.4%) than where it was incomplete (31.3%) (p , 0.0001) or equivocal (27.8%) (p , 0.0001). CONCLUSIONS: Patients with incomplete or equivocal ...
Abstract. Background: Atypical squamous cell cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and low-grade intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) are ambiguous diagnostic entities for the prediction of high-grade cervical lesion. Objective and reproducible tests for predicting high-grade cervical lesions are needed to reduce unnecessary colposcopic referrals or follow-ups.. Objective: We aimed to identify an adequate set of adjunctive markers to predict cervical intraepithelial neoplasia grade 2+ (CIN2+) in residual liquid-based cytology specimens (LBCS).. Methods: We conducted p16 INK4a/Ki-67 and L1 capsid protein immunostaining and human papillomavirus (HPV) DNA typing on 56 LBCS diagnosed with ASC-H or LSIL-H, all of which were subjected to histologic confirmation or follow-up cytologic examination.. Results: Positivity for p16 INK4a/Ki-67 was associated with a histology of CIN2+ (P=0.047) and CIN3+ (P=0.002). Negativity for ...
Initially submitted June 1, 2009; accepted for publication August 5, 2009.. Correspondence to Dr. Philip E. Castle, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, MSC 7234, Bethesda, MD 20892-7234 (e-mail: [email protected]).. Misclassification of exposure and surrogate endpoints of disease can obscure causal relations. Using data from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS, 1997-2001), the authors explored the impact of exposure (human papillomavirus (HPV) detection) and endpoint (histologic cervical precancer) classification on their mutual association. Women referred into this study with an atypical squamous cells of undetermined significance Papanicolaou test with satisfactory results for all 4 HPV tests were included in this analysis (n ¼ 3,215; 92.2%). HPV testing results were related to differentdefinitions of cervical precancer, based on ...
Results Overall, 2790 women (6.9%) tested positive for LR-HPV types, with HPV6 and HPV70 being the most frequent types detected, whereas HPV11 was uncommon. The highest prevalence was observed in the youngest age group (≤19 years). The LR-HPV prevalence was 6.3% in women with normal cytology, 33.1% in atypical squamous cells of undetermined significance (ASCUS), 19.6% in low-grade squamous intraepithelial lesion and 12.7% in those with high-grade squamous intraepithelial lesion. When considering women with LR-HPV alone, the prevalence was 2.0% (normal cytology), 11.3% (ASCUS), 2.6% (low-grade squamous intraepithelial lesion) and 0.7% in women with high-grade squamous intraepithelial lesion, respectively. A similar pattern was observed in relation to the histological diagnoses with the majority of LR-HPV infections detected in CIN1 lesions (24.7%).. ...
Tabrizi SN, Law I, Buadromo E, Stevens MP, Fong J, Samuela J, Patel M, Mulholland EK, Russell FM, Garland SM. Human papillomavirus genotype prevalence in cervical biopsies from women diagnosed with cervical intraepithelial neoplasia or cervical cancer in Fiji. SEXUAL HEALTH 8 (3) : 338 - 342(2011) PubMed ...
Background: The ALTS (atypical squamous cells of undetermined significance [ASCUS] and low-grade squamous intraepithelial lesion [LSIL] Triage Study) suggests that, for women diagnosed with ASCUS, human papillomavirus (HPV) DNA testing followed by referral to colposcopy of only those women with oncogenic HPV (i.e., HPV DNA testing) is as effective at detecting cervical intraepithelial neoplasia (CIN) 3 or cancer (CIN3+) as referring all women with ASCUS for immediate colposcopy. We conducted a cost-effectiveness analysis of the ALTS trial to determine whether HPV DNA testing is a cost-effective alternative to immediate colposcopy or conservative management with up to three cytology examinations. Methods: Data from the ALTS trial were used in conjunction with medical care costs in a short-term decision model. The model compared the incremental costs per case of CIN3+ detected as measured by the incremental cost-effectiveness ratio (ICER) for the following management strategies for women with ...
Background: Women infected with human immunodeficiency virus type 1 (HIV-1) and -2 may be at higher risk of developing cervical cancer than uninfected women. We assessed the relationships among human papillomavirus (HPV) types and persistence, HIV-1 and/or HIV-2 infection, and the development of high-grade cervical squamous intraepithelial lesions (HSILs) in a prospective study. Methods: We studied 627 women with and without HIV-1 and/or HIV-2 infection and high-risk HPV infection in Senegal, West Africa, who were assessed every 4 months for HSIL and HPV DNA over a mean follow-up of 2.2 years. Cox regression modeling was used to assess risks associated with development of HSIL. Results: During follow-up, 71 (11%) of 627 women developed HSIL as detected by cytology. HIV-infected women with high-risk HPV types were at greatest risk for development of HSIL. In multivariable modeling, infection with oncogenic HPV types-both persistent (hazard ratio [HR] = 47.1, 95% confidence interval [CI] = 16.3 to ...
Sponsor. American College of OB/GYN. Principal Investigator. Dr. Lisa Rahangdale, Obstetrics and Gynecology. Project Run Dates. 7/1/2010 to 7/31/2013. Summary. Cervical cancer is the 3rd leading cause of cancer worldwide. Human papillomavirus (HPV) infection is the precursor to cervical dysplasia and cancer. Though the majority of HPV infections are cleared by the bodys immune system, cervical dysplasia that persists and progresses to Cervical Intraepithelial Neoplasia 2/3 (CIN 2/3 or moderate/severe dysplasia) requires repeated cytologic screening, biopsies or excisional/ablative therapy. The management of CIN 2 is particularly challenging as nearly half of these lesions regress, particularly in young women. However, approximately one third will persist and the remaining may progress to CIN 3. We currently are not able to predict which lesions will regress, persist, recur or advance. As a result, providers are compelled to treat women surgically since there are currently no medical therapies ...
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TY - JOUR. T1 - Outcomes after an excisional procedure for cervical intraepithelial neoplasia in HIV-infected women. AU - Reimers, Laura L.. AU - Sotardi, Susan. AU - Daniel, David. AU - Chiu, Lydia G.. AU - Van Arsdale, Anne R.. AU - Wieland, Daryl L.. AU - Leider, Jason M.. AU - Xue, Xiaonan (Nan). AU - Strickler, Howard. AU - Garry, David J.. AU - Goldberg, Gary L.. AU - Einstein, Mark H.. PY - 2010/10. Y1 - 2010/10. N2 - Objective: To determine predictors of treatment failure and recurrence after surgical excisional procedures for CIN in HIV-infected women. Methods: A retrospective cohort study was conducted in which 136 eligible HIV-infected women treated for CIN between 1999 and 2005 were included. Data were abstracted from charts and computer databases. Treatment failures were defined as the presence of CIN 1+ at initial follow-up. Recurrences were defined as the presence of CIN 1+ subsequent to initial normal follow-up. Results: Treatment failure at initial follow-up was common, ...
Cervical Intraepithelial Neoplasia (CIN) is a precursor to invasive cervical cancer, which annually accounts for about 3700 deaths in the United States and about 274,000 worldwide. Early detection of CIN is important to reduce the fatalities due to cervical cancer. While the Pap smear is the most common screening procedure for CIN, it has been proven to have a low sensitivity, requiring multiple tests to confirm an abnormality and making its implementation impractical in resource-poor regions.
low-grade squamous intraepithelial lesion (lgsil) is a type of precancerous changes in the cervix. these lesions may go away on their own, but over time, they may become more abnormal, eventually beco
The present primary therapy of cervical intraepithelial neoplasia (CIN) grade 3 and persistent CIN 2 represents conisation. Surgical treatment can cause
Our findings suggest that women with a first cytological diagnosis of atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion up to age 27 years may indeed be safely followed up with repeat cytology within 6 months. A large amount of colposcopies that are curre …
Raju, G.C., Teh, M., Wee, A. (1996). An immunohistochemical study of p53 protein in cervical intraepithelial neoplasia and squamous cell carcinoma. Pathology 28 (1) : 17-19. [email protected] Repository. https://doi.org/10.1080/ ...
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HIV-infected adolescent females should be referred for colposcopy if they have any of the following: squamous intraepithelial lesion (SIL), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), or atypical squamous cells-cannot exclude a high grade intraepithelial lesion (ASC-H). For HIV-infected adolescent females with atypical squamous cells of undetermined significance (ASC-US), either immediate referral to colposcopy or repeat cytology in 6-12 months is recommended. If ASC-US or greater is found on repeat cytology, referral to colposcopy is warranted (BIII). Use of HPV testing is not recommended for screening or for triage of HIV-infected women with abnormal cytology results or follow-up after treatment (BIII) ...
Investigator] Cruickshank M; Murray G; Parkin D; Smart L; Walker E; Waugh N; Avis M; Chilvers C; Fielding K; Hammond R; Jenkins D; Johnson J; Neal K; Russell I; Seth R; Whynes D; Duncan I; Robertson A; Little J; Sharp L; Russell I; Walker L; Anthony B; Bell S; Bowie A; Brown K; Brown J; Chew K; Cochran C; Cotton S; Dean J; Dunn K; Edwards J; Evans D; Fenty J; Finlayson A; Gallagher M; Gray N; Heddle M; Innes A; Jobson D; Keillor M; MacGregor J; Mackenzie S; Mackie A; McPherson G; Okorocha I; Reilly M; Rodgers J; Thornton A; Yeats R; Alexander L; Buchanan L; Henderson S; Iterbeke T; Lucas S; Manderson G; Nicol S; Reid G; Robinson C; Sandilands T; Adrian M; Al-Sahab A; Bentley E; Brook H; Bushby C; Cannon R; Cooper B; Dowell R; Dunderdale M; Gabrawi; Guo L; Heideman L; Jones S; Lawson S; Philips Z; Platt C; Prabhakaran S; Rippin J; Thompson R; Williams E; Woolley C; Boroujerdi M; Cotton S; Harrild K; Norrie J; Day N; Marteau T; Parmar M; Patnick J; Woodman C; Altman D; Moss S; Wells M; Sharp L; ...
Results Prevalence of cervical infections with any of the 25 LR-HPV types was 10.0% (95% CI: 8.1%-11.9%) and with exclusively LR-HPV types 4.5% (95% CI: 3.2%-5.8%). Prevalence of infections with any LR-HPV types among women with normal cytology was 8.8%, with atypical squamous cells of undetermined significance (ASC-US) 30.4%, with low grade squamous intraepithelial lesions (LSIL) 60.0%, and with high grade squamous intraepithelial lesions (HSIL) 7.7%. LR-HPV types without coexisting HR-HPV types were found in 4.0% of women with normal cytology, 26.1% with ASC-US, 6.7% with LSIL, and none with HSIL. Infections with exclusively HPV 6 or HPV 11 were not found.. ...
In a meta-analysis reported in The Lancet Oncology, Arbyn et al found that posttreatment high-risk human papillomavirus (HPV) testing was a better predictor of recurrence of high-grade cervical intraepithelial neoplasia of grade 2 or higher (CIN2+) than incomplete cervical excision.. Study Details. The meta-analysis included 97 studies, from a literature search covering January 1975 to February 2016, representing a total of 44,446 women treated for cervical precancer. The studies were eligible if patients had undergone treatment by excision of a histologically confirmed CIN2+ lesion with verification of the presence or absence of cervical intraepithelial neoplasia at the resection, were tested by cytology or HPV assay between 3 months and 9 months after treatment, and had subsequent follow-up of at least 18 months posttreatment including histologic confirmation of the occurrence of CIN2+. Treatment failure associated with marginal status was defined as occurrence of residual or recurrent ...
TY - JOUR. T1 - The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. AU - Chang, Junn Liang. AU - Tsao, Yeou Ping. AU - Liu, Dai Wei. AU - Han, Chih Ping. AU - Lee, Wei Hwa. AU - Chen, Show Li. PY - 1999/4. Y1 - 1999/4. N2 - Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found ...
In a study reported in the Journal of Clinical Oncology, Mahmud et al evaluated the effectiveness of the quadrivalent human papillomavirus (HPV) vaccine against cervical dysplasia using population-based individual level data routinely collected in Manitoba. They found that a high proportion of vaccinated women may not be protected against high-grade squamous intraepithelial lesions and lesser dysplasia, particularly those vaccinated at age ≥ 18 years and those with abnormal cytology before vaccination.. Study Details. In the study, 3,541 females aged ≥ 15 years who privately received the quadrivalent vaccine in Manitoba between September 2006 and April 2010 were matched for age with up to three unvaccinated females (n = 9,594). Cox regression models were used to estimate risk for atypical squamous cells of undetermined significance, low-grade squamous intraepithelial, and high-grade squamous intraepithelial lesions.. Most vaccinated subjects (61%) and unvaccinated subjects (64%) were aged 15 ...
Pathology and Laboratory Medicine is a chapter in the book, Gynecology, containing the following 18 pages: Anti-Mullerian Hormone, Markers of Ovarian Reserve, Breast Cancer Gene Marker, BRCA1, BRCA2, Pap Smear, Benign Pap Smear Changes, Atypical Squamous Cells of Undetermined Significance, Low Grade Squamous Intraepithelial Lesion, High Grade Squamous Intraepithelial Lesion, AGUS Pap Smear, Inadequate Pap Smear, Serum Estradiol, Serum Progesterone, Mid-Luteal Serum Progesterone, Progesterone Challenge Test, Estrogen-Progesterone Challenge Test, Vaginal pH.
The aim of this research was to study the correlation between tissue tumor marker expression and HR-HPV infection, smoking, hormonal contraceptive use and sex steroids in women with cervical intraepithelial neoplasia or normal epithelium. The study investigated the expression of 11 tumor markers in cervical biopsies obtained from 228 women with different diagnoses ranging from normal cervical epithelium to various stages of CIN. 188 women were recruited at our colposcopy clinic (out-patient surgery, Department of Obstetrics and Gynecology, Falun Hospital) for laser cervical conization or a directed punch biopsy, either because of a vaginal smear (Pap smear) that showed cytological findings suggesting CIN, or because of repeated findings showing atypical squamous cells of undetermined significance (ASCUS). For 40 volunteers, punch biopsies were taken from the normal cervical epithelium. The time period for this study was 2005-2007.. Study I : 228 women, of whom 116 were tested, 64 were positive ...
Given that high-risk human papillomavirus (HPV) is the necessary cause of virtually all cervical cancer, the clinical meaning of HPV-negative cervical precancer is unknown. We, therefore, conducted a literature search in Ovid MEDLINE, PubMed Central, and Google Scholar to identify English-language studies in which (i) HPV-negative and -positive, histologically confirmed cervical intraepithelial neoplasia grade 2 or more severe diagnoses (CIN2+) were detected and (ii) summarized statistics or deidentified individual data were available to summarize proportions of biomarkers indicating risk of cancer. Nineteen studies including 3,089 (91.0%) HPV-positive and 307 (9.0%) HPV-negative CIN2+ were analyzed. HPV-positive CIN2+ (vs. HPV-negative CIN2+) was more likely to test positive for biomarkers linked to cancer risk: a study diagnosis of CIN3+ (vs. CIN2; 18 studies; 0.56 vs. 0.24; P , 0.001) preceding high-grade squamous intraepithelial lesion cytology (15 studies; 0.54 vs. 0.10; P , 0.001); and ...
Recent literature data suggest that the high-risk human papillomaviruses (HR-HPVs) testing with several molecular techniques could be an alternative to cytology in the detection of cervical intraepithelial neoplasias of grade 2 or worse (CIN2+). However, any molecular techniques have its own limits and may give false negative results which must be clearly known before undertaking a primary HPV screening. This study aims to evaluate the performance of the high-risk HPV hybrid capture II detection kit (HCII) which is considered as a “gold standard technique” in a series of 100 women having proved both cytological lesions of atypical squamous cells-cannot exclude an HSIL (ASC-H) or high-grade squamous intraepithelial lesion (HSIL) and histological lesions of CIN2+. The clinical sensitivity of HCII in women with a cytological diagnosis of ASC-H/HSIL and a diagnosis of CIN2+ is high but not absolute and estimated at 96% (95,6% and 100% of women with a diagnosis of CIN2/3 or
There is evidence that testing for HPV E6/E7 mRNA is more specific than testing for HPV DNA. A retrospective study was carried out to evaluate the performance of the PreTect HPV-Proofer E6/E7 mRNA assay (Norchip) as a triage test for cytology and HPV DNA testing. This study analyzed 1201 women, of who 688 had a colposcopy follow up and 195 had histology-confirmed high-grade intraepithelial neoplasia or worse (CIN2+). Proportion of positive results and sensitivity and specificity for CIN2+ were determined for HPV mRNA in comparison with HPV DNA and cytology. All data were adjusted for follow-up completeness. Stratified by cytological grades, HPV mRNA sensitivity was 83% (95%CI 63-94%) in ASC-US (Atypical Squamous Cells of Undetermined Significance), 62% (95%CI 47-75%) in L-SIL (Low-grade Squamous Intraepithelial Lesion), and 67% (95%CI 57-76%) in H-SIL (High-grade Squamous Intraepithelial Lesion). The corresponding figures were 99%, 91%, and 96%, respectively, for HPV DNA. The specificities were ...
The ability to derive a causal link between vaginal microbiota and HPV infection and CIN/cervical cancer is limited by the cross-sectional nature of most studies undertaken in this area. This difficulty is further compounded by the slow natural history of the disease, with time from acute HPV infection to high-grade CIN taking years to decades. In addition, numerous other confounders can impact results including smoking [46] and vaginal intercourse without the use of barrier contraception [47], which have both been associated with depletion of Lactobacillus spp. The impact of other sexual practices such as oral intercourse, use of lubricants and having multiple sexual partners is poorly understood, and the information gathered in the current observational studies is very heterogeneous as highlighted in Table 1. This information may represent major confounders affecting the VM composition as well as the presence of oncogenic HPV infections and should be clearly documented in future ...
To determine the results of combined cytology and high-risk human papilloma virus (HR HPV) tests at 6 and 18 months postcolposcopy treatment at one Irish colposcopy centre.All women who attended the centres colposcopy smear clinic for a co-test 6 months (initial test) posttreatment were included in the audit (n = 251).The results revealed negative HR HPV for 79 % (n = 198) of women tested 6 months after treatment and positive results for 21 % (n = 53). HR HPV testing was more sensitive than cytology and led to early detection of residual disease. No women with negative HR HPV had high-grade cytology.HR HPV is more sensitive than cytology for detection of persistent CIN. However, 19 women with positive HR HPV had normal colposcopy with no persistent CIN detected. A national cost-benefit analysis is recommended to determine the value of the second co-test ...
Background: DNA ploidy analysis of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer samples by flow cytometry (FCM) has been established as an aid to prognostic assessment. Liquid based cytology (LBC) increases diagnostic specificity by using ancillary techniques that provide information beyond morphology. The present study was undertaken to assess DNA ploidy in LBC samples as an adjunct for early detection of cervical pre-cancer and cancer. Methods: DNA ploidy assessment was performed on LBC samples of 50 cases and 31 controls. Cell pellets were obtained by centrifugation and stained with Telford reagent. At least 20,000 R1 gate (G0-G1) events were acquired on a BD FACSCalibur by using a 575±10 nm filter. Results: Mean diploid G1 values were lowered significantly (p|0.01) while diploid S values were significantly elevated (p|0.01) in both high grade squamous intraepithelial lesions (HSILs) and squamous cell carcinomas (SCCs) as compared to controls. Receiver operating curve (ROC
INTRODUCTION. The most effective approach to cervical cancer control is early diagnosis and treatment of precursor lesions called cervical intraepithelial neoplasia (CIN) and invasive lesions at early stages, with chance of cure in nearly 100%.9. Cervical cancer prevention and control strategies in Brazil have been planned based on distribution of cervical lesions by age and frequency of Pap smears. Declining cervical cancer rates can be attributed to both the Viva Mulher Program, which increased detection of CIN, low-grade cervical squamous intraepithelial lesion (LGSIL) and high-grade cervical squamous intraepithelial lesion (HSIL), and the successful treatment referral through the See and Treat program, which was implemented by the Brazilian Ministry of Health in 1997. At the See and Treat program, a woman cytologically and colposcopically diagnosed with LGSIL undergoes loop electrosurgical excision procedure (LEEP).13 LEEP is a relatively safe, low-cost outpatient procedure performed under ...
Well differentiated villoglandular adenocarcinoma of uterine cervix is a rare tumour which usually occurs in young women. It is considered to be an indolent tumour with favorable prognosis and most of them were treated by conservative procedures. We report a 35 year old lady who came with complaints of 3 months amenorrhoea and an episode of spontaneous bleeding. Urine pregnancy test was negative. Physical examination revealed a cervical polyp. Histopathological findings were consistent with villoglandular papillary adenocarcinoma associated with high grade cervical intraepithelial neoplasia (CIN-3). Left parametrial and left ureteral involvement, proved by biopsy, causing left hydroureteronephrosis was detected. The patient was thus found to be in an advanced stage, stage- III b (FIGO). The patient is currently undergoing radiotherapy. A review of literature showed that only occasional cases showing disease spread have been reported, suggesting caution in the management and regular follow up of ...
TY - JOUR. T1 - Colposcopy quality control by remote review of digitized colposcopic images. AU - Ferris, Daron Gale. AU - Litaker, Mark S.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - This study was undertaken to estimate the accuracy of colposcopy quality control review of subjects digitized colposcopic images during the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion triage study (ALTS). After colposcopic examination and the acquisition of 2 digitized cervical images, colposcopists recorded colposcopic diagnoses in a standardized computer database. The images were transferred by modem to colposcopy quality control reviewers for a blinded interpretation, including assessment of image quality. Reviewers and colposcopists diagnoses were compared with histologic diagnoses using standard contingency table methods. Colposcopists and reviewers underdiagnosed 16.1% and 25.3% of subjects, and overdiagnosed 44.7% and 19.8% of subjects compared with histology, ...
Human papillomavirus (HPV) is widely accepted as a causative agent of cervical cancer. The distribution and prevalence of HPV types depend on geographic region and demographic factors. The aim of this study was to investigate the relationship between the presence of various HPV types and the outcome of cytological examination. Cervical smears were obtained from 125 women from southern Poland: low grade squamous intraepithelial lesions (LSIL) - 44, high grade squamous intraepithelial lesions (HSIL) - 12, cervical carcinoma - 27 and 42 women without abnormality in cytology as a control group. DNA was extracted from the smears and broad-spectrum HPV DNA amplification and genotyping was performed with the SPF 10 primer set and reverse hybridisation line probe assay (INNO-LiPA HPV Genotyping, Innogenetics). HPV DNA was detected in approximately 72% cases, more frequently in women with squamous intraepithelial lesions and cervical carcinoma than in the control group (P , 0.0005). The most frequent ...
Definition of cervical intraepithelial neoplasia. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
TY - JOUR. T1 - Accuracy of thin-layer cytology in patients undergoing cervical cone biopsy. AU - Bergeron, C.. AU - Bishop, John W. AU - Lemarie, A.. AU - Cas, F.. AU - Ayivi, J.. AU - Huynh, B.. AU - Barrasso, R.. PY - 2001. Y1 - 2001. N2 - OBJECTIVE: To compare the accuracy of thin-layer cytology with Autocyte PREP® (TriPath Imaging Inc., Burlington, North Carolina, U.S.A.) with conventional smears in 500 women undergoing cervical cone biopsy. STUDY DESIGN: The study was performed among 500 consecutive women presenting for cone biopsy for high grade cervical intraepithelial neoplasia (CIN) on biopsy in 350 (70%) and discrepant cytology/colpohistology in 150 (30%). Before performing a cone biopsy, two cervical samples were collected for conventional smears and thin-layer cytologic slides, with randomization of the order. Conventional smears were stained and diagnosed at Pasteur Cerba, while thin-layer cytologic slides were processed at a local TriPath office (Meylan, France) and sent in a ...
TY - JOUR. T1 - Effect of glutathione-S-transferase M1 and T1 allelic polymorphisms on HPV-induced cervical precancer formation. AU - Cseh, József. AU - Pázsit, Emese. AU - Orsós, Zsuzsa. AU - Marek, Erika. AU - Huszár, András. AU - Balogh, Sándor. AU - Ember, I.. AU - Kiss, István. PY - 2011/9. Y1 - 2011/9. N2 - Aim: The effect of GSTM1 and GSTT1 allelic polymorphisms was studied on the HPV-induced cervical carcinogenesis. Patients and Methods: Two hundred and fifty-three women with persistent high-risk HPV infection were involved in the study; 117 of them developed cervical high-grade dysplasia and/or cervical intraepithelial neoplasia grade III during the 7-year follow-up period. Occurrence of GSTM1 and GSTT1 null genotypes was compared between women with and without dysplasia. Results: Presence of GSTM1 (OR=1.78, 95% CI=1.06-2.97; p=0.028) and GSTT1 (OR= 1.89, 95% CI=1.10-3.26; p=0.022) null genotypes was statistically significantly more frequent among women with cervical dysplasia ...
The American Society for Colposcopy and Cervical Pathology developed guidelines in 2001 for the management of cervical cytologic abnormalities. The guidelines incorporate the Bethesda System 2001 terminology and data from randomized studies of atypical squamous cells, low-grade intraepithelial lesions, human papillomavirus testing, and liquid-based cytology to formulate evidence-based recommendations. Each recommendation is graded according to the strength of the recommendation and the quality of the evidence, and specific terminology is added to highlight management options. The effectiveness of each triage recommendation is determined by the percentage of grade 2 and 3 cervical intraepithelial neoplasia it detects. Colposcopy, repeat cytology, and human papillomavirus DNA testing are acceptable options in women with atypical squamous cells of undetermined significance, but human papillomavirus DNA testing is preferred if liquid-based cytology is used. Colposcopy is recommended for women with a
Objectives. Infection with high-risk human papillomavirus (HPV) is a critical factor associated withcarcinogenesis of the uterine cervix. HPV-16 is most frequently found, and is further subclassified into intratypicvariants based on the nucleotide sequences of the viral genes. Although certain HPV-16 variants are reported tobe associated with the progression of cervical lesions, these relationships remain controversial with differentresults for different populations. To provide data for another population, we investigated the prevalence ofHPV-16 and distributions of its intratypic variants among Mongolian women with cervical intraepithelialneoplasia (CIN) and invasive cervical cancer. Materials and Methods. We analyzed samples from 374 randomlyselected women who attended the National Cancer Center of Mongolia between January 2002 and July 2007,including 147 invasive cervical cancer patients, 127 CIN patients and 100 age-matched controls who werecytologically normal. HPV genotyping was initially
Detection of high-grade squamous intraepithelial lesions (HSILs) on an anal Pap smear had a sensitivity of 47% (95% CI, 35%59%) and specificity of 90% (95% CI, 81%96%) for detection of a high-grade histological finding (AIN level 2, AIN level 3, or SCC) in the paired specimen. Likewise, detection of low-grade squamous intraepithelial lesions (LSILs) on an anal Pap smear had a sensitivity of 68% (95% CI, 56%78%) and a specificity of 48% (95% CI, 36%59%) for detection of AIN level 1 by the paired examination. A Pap smear finding of atypical squamous cells of uncertain significance showed essentially an equal distribution of pathological grades on paired histological examinations. The positive and negative predictive values were 81% (95% CI, 66%92%) and 65% (95% CI, 55%74%), respectively, for HSIL on Pap smears predicting high-grade histological findings (P < .01). The positive and negative predictive values for LSIL were 59% (95% CI, 48%69%) and 57% (95% CI, 44%70%), respectively, for prediction ...
Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in intraepithelial neoplasia grade 3 of the cervix. DNA samples from 28 cervical adenocarcinoma, 55 squamous cell carcinoma and 31 intraepithelial neoplasia grade 3 (CIN3), previously characterized in terms of human papillomavirus (HPV) prevalence and genotype distribution, were analyzed for TP53 and PIK3CA mutations in the exons 4-9 and exon 9, respectively. Single nucleotide substitutions in TP53 and PIK3CA genes were detected in 36% and 11% of adenocarcinoma, in 16% and in 5% of squamous cell carcinoma, and in 13% and none of CIN 3, respectively. Nucleotide changes in TP53 were significantly more frequent in adenocarcinoma cases than in squamous cell carcinoma and CIN3 (P = 0.035) and were independent from HPV infection
The abnormal readings that predict cervical cancer are called cervical dysplasia, meaning that the cells of the cervix have been altered by the presence of HPV. These readings can be either LGSIL (low-grade squamous intraepithelial lesions) or HGSIL (high-grade squamous intraepithelial lesions). The higher the grade, the more abnormal the cells, and the closer to cancer it is. However, these LGSIL and HGSIL do not mean that cancer is present, only that abnormalities are present that may lead to cancer. When a pap test shows LGSIL or HGSIL, this means that HPV is definitely present, so there is no need to do a specific HPV test. (More on abnormal Pap testing in a later blog post ...
Cervical intraepithelial neoplasia in postmenopausal women with negative cervical cytology. Roberts, Anthony D.G.; Denholm, Rodney B.; Cordiner, J.W. // British Medical Journal (Clinical Research Edition);1/26/1985, Vol. 290 Issue 6464, p281 Examines cases of cervical intraepithelial neoplasia among postmenopausal women. Need for cytological surveillance of women into old age; Treatment of the disease by biopsy; Details of patients with negative results on cytological examination and atypical transformation zone. ...
The most common indication for colposcopy is an abnormal cervical cancer screening test. Women with a Pap smear report of atypical squamous cells, cannot exclude HSIL (ASC-H) or low-grade squamous intraepithelial lesion (LSIL) or worse should be evaluated by colposcopy. Women with atypical squamous cells of undetermined significance (ASCUS) on cytology may have cytology repeated after 6 months or undergo HPV testing or be directly referred for colposcopy. Visual inspection with acetic acid (VIA)-positive women may have colposcopy or direct treatment, depending on the facilities available. Women positive on an HPV test can have triaging with cytology or VIA or may be directly referred for colposcopy ...
Objectives:To assess the associations between microbiological markers of vaginal dysbiosis and incident/cleared/type-swap/persistent high-risk human papillomavirus (hrHPV) infection; and incident/cured/cleared/persistent high-grade cervical intraepithelial neoplasia (CIN2+) while controlling for per
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer form forming, growing, or coming back. Vaccines may help the body build an effecti
We studied histologic examination-related factors contributing to false-negative colposcopic biopsy results. Patients positive for high-risk human papillomavirus (HPV) DNA with negative cervical histologic findings were identified between January 2002 and December 2003. Three additional H&E-stained levels were obtained when the original diagnosis was confirmed on review. Patients with atypical squamous cells of undetermined significance (ASC) Papanicolaou test results, positive HPV DNA results, and negative cervical histologic findings accounted for 4.5% of all ASC smears submitted for HPV DNA testing. Slides and tissue blocks were available for 95 cases; 4% had focal HPV infection or mild dysplasia. When deeper levels were examined, 31% had clinically significant lesions: HPV infection or cervical intraepithelial neoplasia (CIN) 1, 19%; CIN 2/3, 8%; and dysplasia, not otherwise specified, 3%. Of the remaining patients, follow-up revealed squamous abnormalities in 25%. About 5% of patients with ...
A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, however, an essential prerequisite in such a setting to avoid overtreatment and higher screening costs. In this study, a series of cervical scrapes collected in PreservCyt liquid-based cytology (LBC) medium from women with cervical cancer (n = 5), cervical intraepithelial neoplasia grade 1-3 (n = 74), and normal cytology (n = 201; further n = 352 collected in SureThin®) were assessed for methylation of the marker regions ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 using the GynTect assay and compared to cobas® HPV and CINtec Plus® biomarker results. All samples from women with cervical cancer, 61.2% of CIN3, 44.4% of CIN2 and 20.0% of CIN1 cases were scored positive for the GynTect methylation assay. In contrast, all CIN, irrespective of severity grade, and carcinomas were positive by both,
The polymerase chain reaction (PCR) has been used to amplify the long control region (LCR) of episomal human papillomavirus type 16 from cervical scrape DNA obtained from a woman with no evidence of cervical disease and a woman with cervical intraepithelial neoplasia grade 3 (CIN 3). An 883 base pair fragment containing the entire LCR was cloned into pUC13 and the DNA sequence determined for both isolates and compared with the prototype HPV type 16 LCR DNA sequence. Nucleotide variation was apparent in the LCRs derived from both women. In the case of the sample derived from the woman with no cervical disease, there were three nucleotide deletions, one insertion, four transversions, and three transitions (overall conservation: 98.7%). In contrast, the LCR derived from the woman with CIN 3 showed significantly more nucleotide variation with two nucleotide deletions, one insertion, nine transversions, and ten nucleotide transitions (overall conservation 97.6%). Using computer analyses coupled with
Host genetic variability modifies the risk of cervical cancer in women infected with oncogenic human papillomavirus (HPV). Studies have reported an association of the TP53 codon 72 arginine and cervical cancer, but the results are inconsistent. We examined the association of this single nucleotide polymorphism (SNP) in women with cervical cancer and cervical intraepithelial neoplasia grade 3, using a family-based association test. We further explored SNPs in two genes that regulate p53 stability: MDM2 (SNP309) and NQO1 (SNP609, SNP465). We also examined the relationship between host genotype and tumor HPV type. We genotyped 577 patients and their biological parents and/or siblings, using PCR-RFLP or Taqman assays. HPVs were typed by sequence-based methods. The transmission/disequilibrium test was used to detect disease-susceptibility alleles. The arginine peptide of TP53 codon 72 was overtransmitted in Caucasian families (P = 0.043), and the significance of this finding was enhanced in a ...
This colposcopy manual was developed in the context of the cervical cancer screening research studies of the International Agency for Research on Cancer (IARC) and the related technical support provided to national programmes. It is thus a highly comprehensive manual, both for the training of new colposcopists and for the continuing education and reorientation of those who are more experienced. This manual offers a valuable learning resource, incorporating recent developments in the understanding of the etiology and pathogenesis of cervical intraepithelial neoplasia (CIN), as well as in colposcopy and cervical pathology.. Expertise in performing satisfactory, safe, and accurate colposcopic examinations requires high competence in the technical, interpretive, and cognitive aspects, and the capability to develop pragmatic and effective management plans and treatment. This comprehensive and concise manual covers all these aspects and serves as a useful handbook for acquiring the necessary skills ...
Overview Cervical dysplasia is associated with abnormal cell growth on the endocervical canal or the surface lining of the cervix. This precancerous condition is sometimes referred to as cervical intraepithelial neoplasia (CIN), and it is more likely in women who require HPV treatment. Risk Factors Cervical dysplasia is most common in women under age 30, but the greatest risk factor for this condition is a persistent HPV infection. Women are more likely to develop a persistent HPV infection if they have multiple sex partners, sex with a partner who has had multiple sex partners, sex with an uncircumcised man, or experienced an early initiation to sexual activity. Causes For most women who contract HPV, their immune system clears out the infection. In others, however, the infection continues and causes cervical dysplasia. There are more than 100 strains of HPV, but HPV 16 and HPV 18 are the 2 types that are strongly associated with cervical dysplasia. Diagnosis For most women, pelvic exams do not ...
PURPOSE To compare the pregnancy outcomes between women who were treated with cold-coagulation versus large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia. METHODS This was a retrospective cohort study of women who had a single cervical treatment between 2010 and 2011. We identified those women who had a singleton pregnancy subsequent to their cervical treatment until September 2017. Women with previous cervical treatment, previous miscarriage or preterm delivery were excluded. RESULTSWe identified 86 women with a pregnancy after LLETZ treatment and 75 women after cold coagulation. Those who had LLETZ when compared to cold coagulation miscarried more often in the first trimester (33.7 vs 17.3%; p = 0.01) than in the second trimester. In women with LLETZ this effect of increased early miscarriage was shown to be prolonged and to persist up to 17 months after excision. Women with LLETZ when compared to cold coagulation had higher spontaneous preterm birth ...
We report an interesting case of a 25-year-ool woman with a septate uterus, double-cervix, and double-vagina malformation undergoing colposcopic examination for Pap smears showing high-grade squamous intraepithelial lesion of her left cervix and atypical squamous cells of undetermined significance, human papillomavirus negative on her right cervix ...
It has also been observed that about 6 in every ten women have abnormal cells in their cervix. This is known as cervical intraepithelial neoplasia (CIN) or cervical Glandular intraepithelial neoplasia (CGIN) - these are not cancerous cells, but there is a risk that they can turn cancerous if they are not treated. It is possible to detect abnormal cells when colposcopy is carried out, but a biopsy would be needed to determine the type of abnormal cells and to state if it can become cancerous or whether treatment is necessary.. Below are the different types of abnormal cells and what they mean:. CIN 1: It is unlikely that these abnormal cells would become cancerous, and they can go away on their own. No treatment is needed, although you would be invited for a cervical screening test in 12 months to know if the cells have disappeared.. CIN 2: This type has a moderate chance of becoming cancerous and treatment will be recommended to remove them.. CIN 3: These cells have a high chance of becoming ...
TY - JOUR. T1 - PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia. AU - Strickland, Amanda L.. AU - Rivera, Glorimar. AU - Lucas, Elena. AU - John, George. AU - Cuevas, Ileana. AU - Castrillon, Diego H.. N1 - Funding Information: Supported by CPRIT grant RP160211 to D.H.C. Research reported in this publication was also supported by the National Cancer Institutes of the National Institutes of Health under award number 5P30CA142543. The authors declare no conflict of interest.. PY - 2019/11/1. Y1 - 2019/11/1. N2 - The diagnosis of endometrioid intraepithelial neoplasia (EIN) is challenging owing to limited sampling, hormonal status, and other confounding histologic variables. Markers such as PTEN or PAX2 can delineate EIN in some cases, but are not wholly reliable. Clearly, new markers of EIN are needed. We explored several potential markers of EIN based rationally on molecular pathways most frequently misregulated in endometrial cancer: the ...
Anal cytology has been suggested as a screening test for the anal cancer precursor high-grade squamous intraepithelial lesion (HSIL). We aimed to assess the prevalence and predictors of initial unsatisfactory anal cytology tests (unsats). The Study of the Prevention of Anal Cancer is a natural history study of anal human papillomavirus (HPV) and precancerous lesions among gay and bisexual men (GBM) of at least 35 years in Sydney, Australia. At each study visit, an anal swab is collected for cytological testing. Unsats are defined as slides with fewer than 2000 nucleated squamous cells and no abnormal cells. Among 617 GBM enrolled, the median age was 49 (range: 35-79) years and 220 (35.7%) were HIV positive. Initial unsats occurred in 61 (9.9%, 95% confidence interval: 7.6-12.5%), and 29 (4.7%, 95% confidence interval: 3.2-6.7%) remained unsatisfactory on repeat cytology. Initial unsats were associated with fewer lifetime anal-receptive partners with a condom (P=0.007); fewer recent ...
To evaluate prospectively the association between serological markers of selected infections, including HPV, and risk of developing cervical cancer (CC) and precancer, we performed a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study that included 184 cases of invasive CC (ICC), 425 cases of cervical intraepithelial neoplasia (CIN) grade 3 or carcinoma in situ (CIS), and 1,218 matched control women. At enrollment participants completed lifestyle questionnaires and provided sera. Subjects were followed-up for a median of 9 years. Immunoassays were used to detect serum antibodies to Human Herpes Virus 2 (HHV-2), Chlamydia trachomatis (CT), Chlamydia pneumoniae, L1 proteins of mucosal and cutaneous HPV types, E6/E7 proteins of HPV16/18, as well as to four polyomaviruses. Adjusted odds ratios (OR) [and 95% confidence intervals (CI)] for CIN3/CIS and ICC risk were respectively: 1.6 (1.2-2.0) and 1.8 (1.1-2.7) for L1 seropositivity to any mucosal HPV
Prophylactic vaccination against HPV 16 and 18 has the potential for effective prevention of high-grade precancer (cervical intraepithelial neoplasia [CIN)] 2/3) and ICC caused by these viruses (globally 50 and 70%, respectively) when employed in women prior to starting sexual activity. To provide data for decisions on HPV vaccination in China, we determined HPV type-distribution in ICC and CIN 2/3 from women of different regions within China. A multicenter study was conducted by randomized sampling of paraffin blocks of 664 ICC (630 squamous cell carcinoma [SCC]; 34 adenocarcinoma [ADC]), 569 CIN 2/3 cases from seven regions of China. Histological diagnosis was confirmed in 1,233 cases by consensus review. HPV DNA was detected using the SPF10 LiPA25 version 1 assay. HPV prevalence was 97.6% in SCC, 85.3% in adenocarcinoma, and 98.9% in CIN 2/3. HPV 16 (76.7%) and HPV 18 (7.8%) were the most common, together accounting for 84.5% of SCC, followed by HPV 31 (3.2%), HPV 52 (2.2%), and HPV 58 ...
Yeah, theres 15 months between my two daughters. vol. Pregnant women with CIN 1 do not require any further evaluation. Sorry i am no use i have only got CIN 1 and not pregnant, i am useless! Obstet Gynecol. Patients diagnosed after 20-24 weeks of gestation generally defer treatment until the time of delivery. This is called cervical stenosis. HPV infects the basal keratinocytes of the cervix and can lead to a series of progressive precancerous changes known as cervical intraepithelial neoplasia (CIN). While the ectropion that accompanies pregnancies facilitates visualization of the transformation zone, it may be mistaken for a cervical abnormality. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. If youre having periods after a cone biopsy you have not got complete cervical stenosis. Cervical cancer is the second most common malignancy in women worldwide. The cervix might become so tightly closed that sperm cant get ...
In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, 11, 42, 43, and 44) and the absence of cyclin D1 expression in 25 (87%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, 31, 33, 39, 45, 51, 52, 56, 58, and 66). The expression of cyclins E, A, and B proteins was increased in both low-risk and high-risk HPV infections. Tetrasomy of chromosomes 1, 3, 11, 17, 18, and X was present in nine lesions, all of which were infected with high-risk HPVs, but was not related to the pattern of cyclin expression. These data provide in vivo evidence that low- and high-risk HPV types alter cell cycle control by different mechanisms and that cell cycle checkpoint abnormalities are induced by high-risk, but not low-risk, HPV infection.. ...
Background: There is evidence of an interaction between HIV and human papillomavirus (HPV) resulting in increased HPV-associated morbidity and cancer mortality among HIV-positive women. This study aims to determine how the natural history of cervical HPV infection differs by HIV status.. Methods: A total of 1,320 women (47% were positive for HIV-1 and/or HIV-2) were followed for an average of two years in Senegal, West Africa between 1994 and 2010. Cytology (with a sub-sample of histology) and HPV DNA testing were performed at approximately 4-month intervals yielding data from over 7,900 clinic visits. Competing risk modeling was used to estimate rates for transitioning between three clinically relevant natural history stages: Normal, HPV, and HSIL (high-grade squamous intraepithelial lesions). Among HIV-positive women, exploratory univariate analyses were conducted examining the impact of HPV type, infection with multiple HPV types, HIV type, CD4+ count, and age.. Results: HIV-positive women ...
Background: Nowadays, molecular biomarkers have critical roles for cancer diagnosis and prognosis in clinical laboratories. Human papillomaviruses are the main agents for etiology of cervical carcinoma. The present survey was conducted to evaluate the genes methylation in cervical cancer and precancerous lesions involvement with HPV genotypes. Materials and Methods: C13orf18 and C1orf166 (MUL1 or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin-Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia. Results: In this survey, HPV18 (61.6%) and HPV16 (42.9%) proved to be the most common HPV genotypes identified by In-House Multiplex Real Time PCR. There were no significant relationship between HPV positivity and the methylated DNA genes mentioned above (p , 0.05). Conclusions: Our MethyLight data demonstrated that these genes could not be considered as specific, ...
Major risk factors for oral squamous cell carcinoma (SCC) are tobacco smoking, a betel quid chewing habit, and heavy alcohol consumption. However, around 15% of oral SCCs cannot be explained by these risk factors. Although oral SCC associated with dental implants is quite rare, there has been a recent gradual accumulation of reports about it. Here, we report a case of primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ (OIN/CIS) in a woman without the major risk factors for oral SCC. A 65-year-old woman was referred to our clinic with a tumor in the right lower gingiva. She had no history of tobacco smoking and only drank socially. Ten years previously, mandibular right posterior teeth had been replaced with an implant-supported porcelain-fused-to-metal restoration in a dental clinic. About 7 years later, she noticed swelling on the lingual side of the gingiva around the implant-supported restoration, and was eventually referred to our clinic with the suspicion of a neoplasia around
Cervix cancer does not spread early. It spreads by way of the lymphatic system. Cervix cancer screening should be offered to all women over 25 years. There is limited evidence of benefit from screening in women aged over 60 years, though the likely yield of screening is low in women over age 60 since the incidence of high-grade cervical lesions declines after middle age. Cervix cancer is preceded by cervical intraepithelial neoplasia (CIN). Surgery for CIN is effective at reducing the risk of subsequent invasive carcinoma.
Authors: Dorothy A Machalek, Fengyi Jin, I Mary Poynten, Richard J Hillman, David J Templeton, Carmella Law, Jennifer M Roberts, Sepehr N Tabrizi, Suzanne M Garland, Annabelle Farnsworth, Christopher K Fairley, Andrew E Grulich
The progression from Cervical Intraepithelial Neoplasia (CIN) to carcinoma in situ (CIS) to invasive squamous cell carcinoma (SCC) is associated with Epithelial to Mesenchymal Transition (EMT). EMT is triggered by secreted growth factors of tumor and host cells. Epidermal Growth Factor (EGF) and Epidermal Growth Factor Receptor (EGFR) are up-regulated in stromal invasion and metastasis, and up-regulate the zinc-finger transcription factor Snail-1, which mediates EMT by inducing E-cadherin down-regulation of and vimentin up-regulation. Adhesion molecules and E-cadherin loss are associated with the acquisition of invasive capacity, high tumor grade and poor prognosis.. In a large series of cervical lesions (CIN1, 2, 3, CIS, SCC), we investigated EMT immuno-expression with a panel of pertinent Antibodies, namely EGFR, Snail-1, E-cadherin, Vimentin, p16, p53. In this series we were able to conclude that. reduced E-Cad expression and acquisition of VIM expression were significantly higher in the ...
Colposcopy and treatment of cervical intraepithelial neoplasia: a beginners' manual. The World Health Organization. Archived ... Used with common vinegar (acetic acid), Lugol's solution is used to identify pre-cancerous and cancerous changes in cervical ...
"Treatment for cervical intraepithelial neoplasia and risk of preterm delivery." JAMA 291, no. 17 (2004): 2100-2106. North, ...
1.7%; grade 2 or higher cervical intraepithelial neoplasia, 6.9% vs. 3.4%; and breast cancer at 40 years of age or older, 3.9% ... Daughters exposed to DES in utero may also have an increased risk of moderate to severe cervical squamous cell dysplasia and an ... Subsequent studies have shown an approximate 40-fold increased risk of vaginal/cervical clear cell adenocarcinoma in women ... an increased cervical transformation zone, and uterine abnormalities, such as T-shaped uterus. These anomalies contribute to an ...
1991). "Management of cervical intraepithelial neoplasia where colposcopy is not available". Cent. Afr. J. Med. 1991 (37): 7-11 ... "Cervical intraepithelial neoplasia in a sexually transmitted diseases' clinic population in Nigeria". J. Obstet. Gynaecol. East ... 1992). "Invasive cervical carcinoma in two sisters". West Afr. J. Med. 1992 (11): 158-161. PMID 1390378. Omigbodun, AO; et al ... Clinicopathologic correlates of disease stage in Nigerian cervical cancer patients J. Obstet. Gynaecol. East. Cent. Afr., 1991 ...
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"HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women". Hum. Immunol. 66 (10): ... haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern ... DQA1*0102 increases risk cervical cancer. In multiple sclerosis DQA1*0102 was the most frequent allele and DQB1*0602 increased ...
"The role of ureaplasma urealyticum infection in cervical intraepithelial neoplasia and cervical cancer". European Journal of ...
For premalignant dysplastic changes, the CIN (cervical intraepithelial neoplasia) grading system is used. Colon cancer: ... Cervical and ovarian cancers: the "FIGO" system has been adopted into the TNM system. ... Eric Lucas (2006-01-31). "FIGO staging of cervical carcinomas". Screening.iarc.fr. Archived from the original on 2008-10-24. ...
"A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia". Tissue Antigens ...
... of immunopotentialization on rate of vaginal smear normalization according to appearance of cervical intraepithelial neoplasia ... These include (chronic) upper genital tract infections, urinary tract infections and cervical dysplasias. The prophylactic use ... cervical length, and vaginal progesterone treatment for preterm birth risk". Microbiome. 5 (1): 6. doi:10.1186/s40168-016-0223- ...
A 2005 study found the sensitivity and specificity of cervicography for cervical intraepithelial neoplasia to be 72.3% and 93.2 ... of colposcopy/biopsy may have missed cases of cervical intraepithelial neoplasia. Stafl A. Cervicography: a new method for ... The procedure is considered a screening test for cervical cancer and is complementary to Pap smear. The technique was initially ... Inappropriate gold standard bias in cervical cancer screening studies. Int J Cancer. 2007 Nov 15;121(10):2218-24. PMID 17657715 ...
... called cervical intraepithelial neoplasia (CIN) or cervical dysplasia; the squamous intraepithelial lesion system (SIL) is also ... 2002). "American Cancer Society Guideline for the Early Detection of Cervical Neoplasia and Cancer". CA: A Cancer Journal for ... 2010). Detailed Guide: Cervical Cancer. Can cervical cancer be prevented? Retrieved August 8, 2011. The American College of ... "Cervical cancer screening". www.cancer.org.au. Retrieved 2020-08-13. Health, Australian Government Department of, Cervical ...
"Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study". ... The cervical epithelium's DNA has been shown to be damaged due to smoking. DNA damage levels in the cervix cells were higher in ... Cervical cancer is treated with surgery up to stage 2A. Local excision via loop cone biopsy is sufficient if detected in the ... Cervical cancer makes up the largest percentage of gynaecological cancers. Women in developing countries tend to present with ...
"Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized ... "Semen can worsen cervical cancer". Medical Research Council (UK). Archived from the original on 2008-08-04. Retrieved 2007-12- ... In addition, researchers in the UK suggest that a hormone in semen can aggravate existing cervical cancer, condom use during ... Condoms may also be useful in treating potentially precancerous cervical changes. Exposure to human papillomavirus, even in ...
"Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized ... Basal body temperature (BBT) and cervical position are checked once per day. Cervical mucus is checked before each urination, ... Assuming the effectiveness ratio of nulliparous to parous users is the same for the Lea's Shield as for the Prentif cervical ... They also provide some protection against cervical cancer. Condoms are often recommended as an adjunct to more effective birth ...
Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a ... In 2008, Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: ... Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3. Aust NZ J ... Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3. Aust NZ J ...
Cervical intraepithelial neoplasia (CIN) grade 2/3 and cervical adenocarcinoma in situ (AIS). Cervical intraepithelial ... neoplasia (CIN) grade 1. Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3. Vaginal intraepithelial neoplasia (VaIN) ... "Cervical Cancer: Statistics". January 2018. "FDA approves first vaccine for cervical cancer". NBC News. Associated Press. 16 ... By making the vaccine's target disease cervical cancer, the sexual transmission of HPV was minimized, the threat of cervical ...
"Cytology-based screening for anal intraepithelial neoplasia in women with a history of cervical intraepithelial neoplasia or ... A similar study was performed in women with a history of cervical cancer or high-grade cervical intraepithelial neoplasia. More ... Stanley, Margaret A; Winder, David M; Sterling, Jane C; Goon, Peter KC (2012). "HPV infection, anal intra-epithelial neoplasia ... Localised disease (carcinoma-in-situ) and the precursor condition, anal intraepithelial neoplasia (anal dysplasia or AIN) can ...
For premalignant dysplastic changes, the CIN (cervical intraepithelial neoplasia) grading system is used.[5] ... Cervical and ovarian cancers: the "FIGO" system has been adopted into the TNM system. ... "FIGO staging of cervical carcinomas". Screening.iarc.fr. Archived from the original on 2008-10-24. Retrieved 2010-10-14 ...
Cervical squamous intraepithelial lesion (SIL), previously called cervical intraepithelial neoplasia (CIN), is a form of ... High-grade prostatic intraepithelial neoplasia is equivalent to CIS of the prostate. ... "Understanding Cervical Changes" (PDF). National Cancer Institute. National Institute of Health. Retrieved 17 June 2014.. [ ... This controversy also depends on the exact CIS in question (i.e. cervical, skin, breast). Some authors do not classify them as ...
According to a study published by Brown in 2000, MF-EIT is able to predict [Cervical intraepithelial neoplasia] (CIN) grades 2 ... an electrical impedance spectroscope named ZedScan I as a medical device supposed to aid cervical intraepithelial neoplasia ... "Relation between tissue structure and imposed electric current flow in cervical neoplasia." Lancet 355(9207):892-5. ... and 3 according to Pap smear with a sensitivity and specificity of 92% each.[53] Whether cervical MF-EIT is going to be ...
"Cervical surgery for cervical intraepithelial neoplasia and prolonged time to conception of a live birth: A case-control study ... 2017). "Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease". The ... The cervical transformation zone and lesion are excised to an adequate depth, which in most cases is at least 8 mm, and ... This scar tissue can be massaged or broken up in a number of ways, thus allowing the cervical opening to dilate back to normal ...
Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from ... p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. The ... The clinical impact of using p16(INK4a) immunochemistry in cervical histopathology and cytology: an update of recent ... encoded transcripts in cervical cancer cells and confirmed the oncogenic role of the viral E6 and E7 proteins in HPV associated ...
All of these changes are treatable with no recurrence Cervical intraepithelial neoplasia Clinical Evidence Concise, BMJ ... Cervical dyskaryosis is classified into three degrees of severity: mild, moderate and severe. A further category is used to ... Dyskaryosis means abnormal nucleus and refers to the abnormal epithelial cell which may be found in cervical sample. It is ... Apparent dyskaryosis below the age of twenty-five is not regarded as significant, and in many countries where cervical ...
CCNA1 and C13ORF18 are strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer in cervical ... "Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors". Mol ...
"Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized ... Observation and charting of basal body temperature, cervical mucus or cervical position. 00.006 ! Throughout day or daily[note ... Basal body temperature (BBT) and cervical position are checked once per day. Cervical mucus is checked before each urination, ... 1999 cervical cap and spermicide (replaced by second generation in 2003)[ref 7]. FemCap. 007.60 !7.6[not in citation given] ( ...
... bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, ... 2007). "Reserve cells in human uterine cervical epithelium are derived from müllerian epithelium at midgestational age". Int J ... Nichols TM, Fidler HK (1971). "Microglandular hyperplasia in cervical cone biopsies taken for suspicious and positive cytology ... Jones MW, Silverberg SG (1989). "Cervical adenocarcinoma in young women: possible relationship to microglandular hyperplasia ...
ADXS-HPV is in Phase 2 trials for HPV-associated diseases (cervical intraepithelial neoplasia (CIN), cervical cancer and HPV- ... recurrent cervical cancer. Vaccine (19 June 2009 / Volume 27, Issue 30) This study demonstrated for the first time that a live- ... including cervical cancer., Advaxis immunotherapies are based on a novel platform technology using live attenuated Listeria ...
... is in development as a local treatment for Cervical intraepithelial neoplasia lesions and human papilloma virus (HPV) of ... With Cevira, Photocure aims to develop the first non-surgical treatment for precancerous cervical lesions using photodynamic ... "Photodynamic Device Developed to Treat Precancerous Cervical Lesions". Medical Advice Network. 18 March 2011. Retrieved 2013-06 ...
In these subgroups, efficacy of nearly 100% against all grades of cervical intraepithelial neoplasia and adenocarcinoma in situ ... Despite this, cervical cancer continues to be a shocking disease for women in the developed world. Women living in poverty in ... He and his team at Princess Alexandra Hospital in Brisbane have developed a vaccine to beat cervical cancers that kill 250,000 ... Ian Frazer's break-through vaccine is 100 per cent effective against the most common form of the virus that causes cervical ...
... cervical cancer - cervical dysplasia - cervical intraepithelial neoplasia (CIN1, CIN2, CIN3) - cervix - chancroid - chemokines ...
Endometrial intraepithelial neoplasia. *Uterine clear-cell carcinoma. Cervix. *Cervical intraepithelial neoplasia. *Clear cell ... Tumors: female urogenital neoplasia (C51-C58/D25-D28, 179-184/218-221) ...
Cervical intraepithelial neoplasia is a possible result of the biopsy, and represents dysplastic changes that may eventually ... as in cervical vertebrae or cervical lymph nodes) or to the uterine cervix (as in cervical cap or cervical cancer). ... including cervical caps and cervical diaphragms aim to block or prevent the passage of sperm through the cervical canal. ... Cervical mucusEdit. Several hundred glands in the endocervix produce 20-60 mg of cervical mucus a day, increasing to 600 mg ...
... normal cervical tissues, cervical intraepithelial neoplasia (CIN) I or below, CIN II or above, and cervical cancer tissues.[9] ... Ye H, Zhang Y, Geng L, Li Z (February 2015). "Cdc42 expression in cervical cancer and its effects on cervical tumor invasion ... In one study studying the role of Cdc42 in cervical cancer, immunohistochemistry was used to detect Cdc42 expression in three ... Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate, possibly due to improved ...
Cervical intraepithelial neoplasia (CIN). *Koilocyte. * Vaginal intraepithelial neoplasia (VAIN). * Vulvar intraepithelial ...
2003). "Condom use Promotes the Regression of Cervical Intraepithelial Neoplasia and Clearance of HPV: Randomized Clinical ... "Cervical Cancer". Cervical Cancer: Cancers of the Female Reproductive System: Merck Manual Home Edition. Merck Manual Home ... "NCCC National Cervical Cancer Coalition". Retrieved 2008-07-01.. *↑ Menczer J (2003). "The low incidence of cervical cancer in ... 2002). "American Cancer Society guideline for the early detection of cervical neoplasia and cancer". CA: a cancer journal for ...
Examples of dysplasia include epithelial dysplasia of the cervix (cervical intraepithelial neoplasia - a disorder commonly ... Analogous conditions include vaginal intraepithelial neoplasia and vulvar intraepithelial neoplasia. Metanephric dysplastic ... "Neoplasia I". Retrieved 24 January 2012.. *^ Ridge JA, Glisson BS, Lango MN, et al. "Head and Neck Tumors" in Pazdur R, Wagman ...
"The role of ureaplasma urealyticum infection in cervical intraepithelial neoplasia and cervical cancer". European Journal of ...
... (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of ... "Colposcopy and treatment of cervical intraepithelial neoplasia: a beginners manual". screening.iarc.fr. Retrieved 2018-12-20.. ... Preinvasive Lesions of the Lower Genital Tract , Cervical Intraepithelial Neoplasia in:. Bradshaw KD, Schorge JO, Schaffer J, ... "Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta- ...
Cervical intraepithelial neoplasia (CIN). *Koilocyte. * Vaginal intraepithelial neoplasia (VAIN). * Vulvar intraepithelial ... HPV types 16 and 18 currently cause about 70% of cervical cancer cases,[11][12] and also cause some vulvar, vaginal,[9] penile ... HIV drug used to reverse effects of virus that causes cervical cancer Archived 2014-03-22 at the Wayback Machine. University of ... Cancers and genital dysplasia - "high-risk" HPV types are associated with cancers, notably cervical cancer, and can also cause ...
Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and ... Cervical cancer prevention in Australia: Planning for the future.". Cancer cytopathology (30 November 2015). PMID 26619381.. ... Cervical cancer prevention: immunization and screening 2015.". The Medical clinics of North America, 99 (3), 469-77 (May 2015 ...
2003). "Condom use Promotes the Regression of Cervical Intraepithelial Neoplasia and Clearance of HPV: Randomized Clinical ... "Cervical Cancer". Cervical Cancer: Cancers of the Female Reproductive System: Merck Manual Home Edition. Merck Manual Home ... "Cervical Cancer". Cervical Cancer: Pathology, Symptoms and Signs, Diagnosis, Prognosis and Treatment. Armenian Health Network, ... "NCCC National Cervical Cancer Coalition". பார்த்த நாள் 2008-07-01. *↑ Menczer J (2003). "The low incidence of cervical cancer ...
Vaginal intraepithelial neoplasia. Notes[edit]. *^ There are four main groups of vaginal neoplasms: benign neoplasms, in situ ...
Cervical intraepithelial neoplasia (CIN). *Koilocyte. * Vaginal intraepithelial neoplasia (VAIN). * Vulvar intraepithelial ... Human papillomavirus infection is a major cause of cervical cancer, although most HPV infections do not cause cancer.[citation ...
... cervical muscle spasms and treatment for referred cervical origin (pain referred from upper levels of the cervical spine) or ... Neoplasia. TMD is considered by some to be one of the 4 major symptom complexes in chronic orofacial pain, along with burning ... TMJ dysfunction is commonly associated with symptoms affecting cervical spine dysfunction and altered head and cervical spine ... there is some evidence of possible adverse effects from cervical (neck) vertebral manipulation, which sometimes may be serious. ...
... targeting HPV-16 and HPV-18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3, it is the first therapeutic vaccine ... synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a ... While the study period was not long enough for cervical cancer to develop, the prevention of these cervical precancerous ... "A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women". The New England Journal of Medicine. 372 (8 ...
Cervical intraepithelial neoplasia (CIN). *Koilocyte. * Vaginal intraepithelial neoplasia (VAIN). * Vulvar intraepithelial ... "Vulvar Intraepithelial Neoplasia: Varied signs, varied symptoms: what you need to know". www.advanceweb.com. Archived from the ... Five percent acetic acid (vinegar) is used to identify both warts and squamous intraepithelial neoplasia (SIL) lesions with ... Since cervical and female genital infection by specific HPV types is highly associated with cervical cancer, those types of HPV ...
Cervical intraepithelial neoplasia, the potential precursor to cervical cancer, is often diagnosed on examination of cervical ... Stage 1A cervical cancer Stage 1B cervical cancer Stage 2A cervical cancer Stage 2B cervical cancer Stage 3B cervical cancer ... cervical intraepithelial neoplasia grading is used.[citation needed] The naming and histologic classification of cervical ... A direct way of contracting this cancer is a smoker has a higher chance of cervical intraepithelial neoplasia (CIN3) occurring ...
Pre-cancerous endometrial hyperplasias are also referred to as endometrial intraepithelial neoplasia. Mutations in the KRAS ... Cervical stenosis, the narrowing of the cervical opening, is a sign of endometrial cancer when pus or blood is found collected ... A cervical screening test, such as a Pap smear, is not a useful diagnostic tool for endometrial cancer because the smear will ... This makes it the third most common cause of death in cancers which only affect women, behind ovarian and cervical cancer. It ...
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia ". The New England Journal of Medicine. 361(19): ... For cervical carcinoma patients, long antigenic peptides derived from HPV proteins were used in cancer vaccines. It was shown ... These are mainly human papilloma virus (HPV) causing cervical carcinoma, and Epstein-Barr virus causing B cell lymphomas and ...
... trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia. ... Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Eur J Cancer Prev. 2003 Oct;12(5): ...
Increasing age History of vulvar or cervical intraepithelial neoplasia Increased number of male sexual partners Prior history ... HPV DNA can be found in up to 87% of vulvar intraepithelial neoplasia (VIN) and 29% of invasive vulvar cancers; HPV 16 is the ... One starts as an infection by human papillomavirus, which leads to vulvar intraepithelial neoplasia (VIN) and potentially on to ... There are two types of precursor lesions: Usual-type vulvar intraepithelial neoplasia (uVIN), which is associated with Human ...
Cervical Cancer Human Papilloma Virus Obstet Gynecol Cervical Intraepithelial Neoplasia Uterine Cervix These keywords were ... Ferenczy A. (1982) Cervical Intraepithelial Neoplasia. In: Blaustein A. (eds) Pathology of the Female Genital Tract. Springer, ... Richart RM (1966) Colpomicroscopic studies of cervical intraepithelial neoplasia. Cancer 19: 395CrossRefGoogle Scholar ... Richart RM (1973) Cervical intraepithelial neoplasia. In: Pathology annual, Sommers, SC (ed) New York, Appleton-Century-Crofts ...
Analysis of cervical precancer shows decline in two strains of HPV An analysis of cervical precancers over a period of seven ... A new method of cervical cancer screening which is designed to be done by women at home could bring down the rates of cervical ... Self-sampling could increase detection of cervical pre-cancer A non-invasive test to detect cervical pre-cancer could increase ... HPV type 16 or 18 associated with cervical cancer risk in young women The human papilloma virus can cause cervical cancer. ...
Definition of cervical intraepithelial neoplasia. Provided by Stedmans medical dictionary and Drugs.com. Includes medical ... cervical intraepithelial neoplasia. Definition: dysplastic changes beginning at the squamocolumnar junction in the uterine ...
Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of ... "Colposcopy and treatment of cervical intraepithelial neoplasia: a beginners manual". screening.iarc.fr. Retrieved 2018-12-20.. ... Preinvasive Lesions of the Lower Genital Tract , Cervical Intraepithelial Neoplasia in:. Bradshaw KD, Schorge JO, Schaffer J, ... "Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta- ...
This introductory manual is intended to simplify the learning of colposcopy and treatment of cervical intraepithelial neoplasia ... will help to equip health care providers with the necessary skills in detecting and treating cervical intraepithelial neoplasia ... Availability of simplified learning resources, training mechanisms and trained providers in cervical cancer prevention may help ... thereby preventing invasive cervical cancer in many women throughout the world.. ...
Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of ... Gajjar K, Martin-Hirsch PP, Bryant A, Owens GL (July 2016). "Pain relief for women with cervical intraepithelial neoplasia ... Preinvasive Lesions of the Lower Genital Tract > Cervical Intraepithelial Neoplasia in:Bradshaw KD, Schorge JO, Schaffer J, ... ISBN 978-1-4160-2973-1. "Colposcopy and treatment of cervical intraepithelial neoplasia: a beginners manual". screening.iarc.fr ...
Cervical Intraepithelial Neoplasia - Genetic Alliance. *Histopathology and cytopathology of the uterine cervix - digital atlas ... Natural history of cervical intraepithelial neoplasia: a critical review.. Ostör AG1. ... The literature dealing with the natural history of cervical intraepithelial neoplasia (CIN) since 1950 is reviewed, in ...
i,Objectives,/i,: As part a Program Project to evaluate emerging optical technologies for cervical neoplasia, our group is ... Quantitative Histopathological Analysis of Cervical Intra-Epithelial Neoplasia Sections: Methodological Issues,. Analytical ... Quantitative Histopathological Analysis of Cervical Intra-Epithelial Neoplasia Sections: Methodological Issues. Martial ... Objectives: As part a Program Project to evaluate emerging optical technologies for cervical neoplasia, our group is performing ...
Treatment options for high-grade cervical intraepithelial neoplasia. Last Reviewed: January 14, 2004 ... Treatment options for high-grade cervical intraepithelial neoplasia include procedures that destroy the abnormal cells (like ... Cervical Cancer Treatment (PDQ®) (Health professionals) Cervical Cancer Screening (PDQ®) (Health professionals) Cervical Cancer ... Pregnancy after Cervical Conizations Pregnancy after LEEP Procedure Hysterectomy to treat cervical dysplasia Cin I Pap Tests ...
cervical intraepithelial neoplasia grade 1. cervical intraepithelial neoplasia grade 2. cervical intraepithelial neoplasia ... Uterine Cervical Neoplasms. Neoplasms. Carcinoma in Situ. Cervical Intraepithelial Neoplasia. Precancerous Conditions. Uterine ... Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia. The safety and scientific validity of this study is the ... Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia: A Pilot Study. ...
Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 1993;12:186-92.. * Cited Here... ... Vandenvelde C, De Foor M, van Beers D. HLA-DOB1*03 and cervical intraepithelial neoplasia grades I-III. Lancet 1993;341:442.. * ... Home , October 2004 - Volume 104 - Issue 4 , Regression of Low-Grade Cervical Intraepithelial Neoplasia i... ... Regression of Low-Grade Cervical Intraepithelial Neoplasia in Patients With HLA-DRB1*13 Genotype. Sastre-Garau, Xavier MD, PhD* ...
Topical Imiquimod Versus Conization to Treat Cervical Intraepithelial Neoplasia (ITIC2). The safety and scientific validity of ... Cervical Intraepithelial Neoplasia. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Imiquimod. ... Background: Alternatives to surgery are needed for the treatment of cervical intraepithelial neoplasia (CIN). CIN is associated ... ITIC2 Trial - Topical Imiquimod Versus Conization to Treat Cervical Intraepithelial Neoplasia: Randomised Controlled, Non- ...
... diagnosis of high-grade CIN is because HPV-18-associated disease rapidly progresses through the preinvasive stages of neoplasia ... Human papillomavirus type 18 and rapidly progressing cervical intraepithelial neoplasia Lancet. 2003 Jan 4;361(9351):40-3. doi ... HPV-18 is rarely detected at the time of diagnosis of high-grade cervical intraepithelial neoplasia (CIN). We used a ... Cervical Intraepithelial Neoplasia / diagnosis * Cervical Intraepithelial Neoplasia / pathology * Cervical Intraepithelial ...
The present primary therapy of cervical intraepithelial neoplasia (CIN) grade 3 and persistent CIN 2 represents conisation. ... Topical Imiquimod in Treating Patients With Grade 2/3 Cervical Intraepithelial Neoplasia. Trial Phase:. Phase 2/Phase 3. ... Topical Imiquimod in Treating Patients With Grade 2/3 Cervical Intraepithelial Neoplasia ...
Cervical surgery for cervical intraepithelial neoplasia and prolonged time to conception of a live birth: a case-control study ... Cervical screening for the early identification and treatment of cervical intraepithelial neoplasia has reduced the incidence ... Objective To determine the impact of cervical excision for cervical intraepithelial neoplasia on fertility and early pregnancy ... We used keywords such as "cervical intraepithelial neoplasia", "cervical cancer", "fertility", "pregnancy", "miscarriage", " ...
... smoking appeared to be the most significant environmental risk factor for cervical neoplasia. © 2000 Cancer Research Campaign ... study in the Västerbotten county of Northern Sweden of 137 women with high-grade cervical intra-epithelial neoplasia (CIN 2-3) ... After the discovery of the very strong link between human papillomavirus (HPV) infection and cervical cancer, it is unclear ... if they are independent risk factors or whether they may act as cofactors to HPV infection in cervical carcinogenesis. To ...
... including the controversial diagnoses of vaginal intraepithelial neoplasia (VAIN). Results: From 1866 patients, 1423 (76.3%) ... in cervical samples is not a common finding. Therefore, we aimed to report VAINs detected in liquid-based cytology (LBC) from ... follow up of treated cervical lesion, ecc) and women examined for regular screening proposals, and compared with biopsy ... Vaginal Intraepithelial Neoplasia Detected with Cervical Liquid-Based Cytology: Old Concerns or New Facilities? ...
Cervical Intraepithelial Neoplasia Human Papilloma Virus Device: Local Hyperthermia at 37℃ Device: LEEP or cold knife Device: ... Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias (HPV). The safety and scientific validity of this ... Cervical Intraepithelial Neoplasia. Fever. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Evaluation of Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias After 3 Months: a Multicenter, Single ...
Cervical Cancer , DNA Methylation Biomarkers for Cervical Cancer Screening ... DNA Methylation Biomarkers for Cervical Cancer Screening Brief description of study. The purpose of this prospective study is ... to evaluate whether DNA methylation can be applied in cervical cancer screening. ...
Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia ( ... Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a ... Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in ... Cervical Intraepithelial Neoplasia Grade 2/3. Known as: CIN 2/3 A condition in which abnormal cells grow on the thin layer of ...
... and cervical intraepithelial neoplasia grade I occur at substantially higher rates than cervical intraepithelial neoplasia ... substantially more cases of condyloma and cervical intraepithelial neoplasia grade I than cervical intraepithelial neoplasia ... for cervical intraepithelial neoplasia (114 v 366 cases) to 83% for vaginal intraepithelial neoplasia (4 v 24 cases) in the ... for cervical intraepithelial neoplasia grade I, 42% for vulvar intraepithelial neoplasia grade I, and 90% for condyloma10 12 27 ...
Exploratory analysis of quantitative histopathology of cervical intraepithelial neoplasia: Objectivity, reproducibility, ... quantitatively assessing progression of the neoplastic process of cervical intraepithelial neoplasia (CIN)/squamous ... Background: As part of a project to evaluate emerging optical technologies for cervical neoplasia, our group is performing ... Optical Technologies and Molecular Imaging for Cervical Neoplasia: A Program Project Update, Gender Medicine, 2012, 9, 1, S7. ...
... objective of this study is to identify potential improvements for a noninvasive method of diagnosing dysplasia and neoplasia in ... A Pilot Study: Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia. Trial ... A Pilot Study: Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia ...
The association of S-100-positive LCs coupled with cervical inflammatory changes suggests an important function of the S-100 ... Evaluation of Langerhans cells in the cervical epithelium of women with cervical intraepithelial neoplasia Gynecol Oncol. 1999 ... Studies that use S-100 immunostaining demonstrate low LCs in cervical intraepithelial neoplasia (CIN) while those that use ... Objective: Cervical infection with human papillomavirus (HPV) results in a more permissive environment for malignant ...
Quantification of HPV-16 E6-E7 transcription in cervical intraepithelial neoplasia by reverse transcriptase polymerase chain ... and this ORF is conserved consistently in cervical intraepithelial neoplasia (CIN). Two mRNAs, generated by alternative ... was applied to exfoliated cervical cells obtained from patients in varying stages of clinically defined CIN and who were ... E6-E7 transcription may be useful as a prognostic tool to identify women who are at increased risk of developing cervical ...
... its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined ... and cervical neoplasia are needed to demonstrate whether and how in some situations C trachomatis sets the stage for cervical ... Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also ...
Insulin-like Growth Factor-I and Risk of High-Grade Cervical Intraepithelial Neoplasia. Andrea Schaffer, Anita Koushik, Helen ... The p53 codon 72 polymorphism and risk of high-grade cervical intraepithelial neoplasia. Cancer Detect Prev 2005;29:307-16. ... The other potential cases had biopsy results indicating invasive disease; low-grade cervical intraepithelial neoplasia; other ... Insulin-like Growth Factor-I and Risk of High-Grade Cervical Intraepithelial Neoplasia ...
Study of Anal Cytologies in Patients With High Grade Cervical Intraepithelial Neoplasia (CIN II and III) ... Study of Anal Cytologies in Patients With High Grade Cervical Intraepithelial Neoplasia (CIN II and III) Brief description of ... Cervical cancer is the third most frequent neoplasm in Brazilian women (estimated risk of 15.33 cases / 100,000 women by 2014 ...
E. E. Sheets, R. G. Urban, C. P. Crum et al., "Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia ... L. A. Koutsky, K. K. Holmes, C. W. Critchlow et al., "A cohort study of the risk of cervical intraepithelial neoplasia grade 2 ... relationship to cervical intraepithelial neoplasia," Clinical and Diagnostic Laboratory Immunology, vol. 3, no. 2, pp. 205-210 ... in Women with High-Grade Cervical Intraepithelial Neoplasia: First-in-Human, Proof-of-Concept Trial. Ana M. Solares,1 Idania ...
You are here: Home / RESEARCH . . . . / Cancer Research / Surveillance after treatment for cervical intraepithelial neoplasia: ... Surveillance after treatment for cervical intraepithelial neoplasia: outcomes, costs, and cost-effectiveness.. March 29, 2011. ... To estimate outcomes and costs of surveillance strategies after treatment for high-grade cervical intraepithelial neoplasia ( ... Estimated outcomes included CIN, cervical cancer, cervical cancer deaths, life expectancy, costs, cost per life-year, and cost ...
  • A new study in The American Journal of Pathology, published by Elsevier, reports that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, was effective in preventing the development of cervical cancer in mice with precancerous lesions. (news-medical.net)
  • While infection with HPV is needed for development of CIN, most women with HPV infection do not develop high-grade intraepithelial lesions or cancer. (wikipedia.org)
  • CIN is classified in grades: The College of American Pathology and the American Society of Colposcopy and Cervical Pathology came together in 2012 to publish changes in terminology to describe HPV-associated squamous lesions of the anogenital tract as LSIL or HSIL as follows below: CIN 1 is referred to as LSIL. (wikipedia.org)
  • To learn if a new type of contrast agent (a dye used in certain types of scans and microscope studies) can be used to detect cervical cancer and precancerous lesions better than standard contrast agents. (knowcancer.com)
  • Objectives in the interim analysis are (a) quantitatively assessing progression of the neoplastic process of cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesions (SIL), (b) detecting malignancy-associated changes (MACs), and (c) phenotypically measuring human papillomavirus (HPV) detected by DNA testing. (wiley.com)
  • Furthermore, one epidemiologic study has reported a strong positive association between high levels of IGF-I and both low-grade and high-grade squamous intraepithelial lesions ( 27 ). (aacrjournals.org)
  • Objective: This study aimed to estimate if risk factor profiles for histologically confirmed cervical intraepithelial neoplasia (CIN) 2 lesions differ from those for CIN 1 or 3. (aacrjournals.org)
  • Cervical lesions as ascertained by histology, termed cervical intraepithelial neoplasia (CIN), are classified in three grades based on increasing degrees of cellular change and disorganization. (aacrjournals.org)
  • To describe whether CIN 2 lesions are epidemiologically more similar to CIN 1 or 3 lesions in the reproductive risk factors among women with these diagnoses, we used data from a cross-sectional study in China: the Shanxi Province Cervical Cancer Screening Study (SPOCCS) II ( 6 ). (aacrjournals.org)
  • We have shown that the detection of HR HPV DNA provides high sensitivity but has lower specificity than cytology for the identification of high-grade cervical lesions in a screening population in the United Kingdom ( 9 ), and this finding has been replicated in several other studies ( 1 , 3 , 8 , 15 - 17 , 21 , 22 , 26 , 27 ). (asm.org)
  • In addition, prospective studies have shown that HPV DNA-positive women who do not have disease initially are significantly more likely to develop high-grade squamous intraepithelial lesions (SILs) within 10 years than women with a negative HPV DNA test ( 4 , 12 , 14 , 18 ). (asm.org)
  • In immune-competent subjects, at least 25% of HPV16 + high-grade cervical dysplasia lesions undergo complete regression. (jimmunol.org)
  • In the U.S., an estimated 2,500,000 women will have abnormal Pap smears demonstrating atypical cells of uncertain significance and low-grade intraepithelial lesions (lesions of HPV and CIN 1) annually (Kurman, 1994). (google.com)
  • The exact number of patients with high-grade squamous intraepithelial lesions (CIN II and III), not classified as carcinoma-in-situ, is unknown. (google.com)
  • Treatment of cervical intraepithelial neoplasia (CIN) lesions depends heavily on CIN grade. (bmj.com)
  • Of 59 women referred with vulval warts whose cervices were assessed colposcopically for the presence of cervical intraepithelial neoplasia (CIN) before local treatment of the wart lesions, 17 had histologically proved CIN, 12 had histologically proved cervical wart virus infection, and 30 had abnormality on colposcopy or cytology. (bmj.com)
  • Three of them developed CIN after adequate treatment of the vulval lesions despite the absence of cervical abnormalities on colposcopy at the time of treatment. (bmj.com)
  • The aim of our study was to investigate whether HPV is present in both CIN III (cervical intraepithelial neoplasia) lesions and bronchopulmonary second primary cancers in women with a clinical history of both diseases. (sanevax.org)
  • Thus, detection of HPV transcripts derived from integrated HPV genomes may specifically indicate both CIN lesions at high risk for progression as well as invasive cervical cancers. (aacrjournals.org)
  • Refine the detection of cervical lesions by fluorescence spectroscopy in these participants using improved classification of normal columnar tissue and non-neoplastic tissue with inflammation. (bioportfolio.com)
  • The functional consequences of variant enzyme properties may include abnormalities in DNA synthesis, repair and methylation, and, thereby, altered susceptibility to precancerous lesions and cervical cancer ( 11 ). (spandidos-publications.com)
  • 30)), and evaluated the influence of obesity on HPV infection and HPV-associated cervical intraepithelial neoplasia (CIN) lesions in this population. (omicsonline.org)
  • The results showed that Ki67 tumor cell proliferation index was the only marker that independently correlated to both the presence of HR-HPV and the severity of cervical lesions. (diva-portal.org)
  • Gain of the chromosomal 3q region, which contains the human telomerase RNA gene on 3q26 , is found in CIN lesions and cervical carcinoma and shows correlation with disease grade. (springer.com)
  • Conventional histopathological assessment is unable to differentiate between high-grade lesions that will progress to cervical cancer and those that will regress spontaneously. (springer.com)
  • Human Papillomavirus (HPV) genotype distribution and co-infection occurrence was studied in cervical specimens from the city of Madrid (Spain), as a contribution to the knowledge of Human Papillomavirus genotype distribution and prevalence of carcinogenic HPV types in cervical lesions in Spain. (biomedcentral.com)
  • These included 19 benign lesions, 349 cervical intraepithelial neoplasias 1 (CIN1), 158 CIN2-3 and 7 invasive cervical carcinomas (ICC). (biomedcentral.com)
  • CC arises through a multistage process of carcinogenesis, and persistence of high risk Human Papilloma Virus (hrHPV) infection represents the major etiological factor for neoplasia development [ 2 - 4 ], through the progression of precursor lesions (i.e. (biomedcentral.com)
  • To evaluate the treatment outcome and acceptance of LEEP in precancerous cervical lesions. (org.np)
  • Hysterectomy is a radical procedure for preinvasive cervical lesions that can be treated with simple procedure like LEEP that saves time and financial resources. (org.np)
  • [ 3 ] Although the test, known as the Papanicolaou smear (or Pap smear or Pap test), continues to be the mainstay of identification of cervical cancer and precancerous lesions of the cervix, it is still not being used to full advantage. (medscape.com)
  • Sadly, despite widespread screening and treatment of pre-invasive lesions, there are still approximately 12,000 new cases of cervical cancer in the United States each year and roughly 4,000 annual deaths from the disease. (medscape.com)
  • The histological grading of cervical intraepithelial neoplasia (CIN) remains subjective, resulting in inter- and intra-observer variation and poor reproducibility in the grading of cervical lesions. (qub.ac.uk)
  • Of the total sample, 23.1% had an abnormal cervical smear, of whom 5.6% showed intraepithelial lesions, both low and high grade. (who.int)
  • 90.9% of the smears showing high grade lesions were histologically confirmed as cervical cancer. (who.int)
  • Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer. (wikipedia.org)
  • citation needed] Historically, abnormal changes of cervical epithelial cells were described as mild, moderate, or severe epithelial dysplasia. (wikipedia.org)
  • Dear OncoLink "Ask The Experts," I had an abnormal pap with high-grade intraepithelial lesion and moderate dysplasia and was recommended a LEEP procedure but I would prefer a partial hysterectomy. (oncolink.org)
  • To identify potential improvements for a noninvasive method of diagnosing cervical dysplasia and neoplasia using digital colposcopy and fluorescence spectroscopic imaging. (clinicaltrials.gov)
  • Butterworth CE, Hatch KD, Gore H, Mueller H and Krumdieck CL (1982) Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. (nature.com)
  • Ho GYF, Palan PR, Basu J, Romney SL, Kadish AS, Mikhail M, Wasserteiler-Smoller S, Runowicz C and Burk RD (1998b) Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia. (nature.com)
  • Cervical intraepithelial neoplasia (CIN) (also known as cervical dysplasia ) is the potentailly premalignant stage in the dysplastic changes in the squamous epithelium of the cervix. (radiopaedia.org)
  • It is important to note that these symptoms are not unique to cervical dysplasia and they may indicate a different problem. (moondragon.org)
  • The precise cause of cervical dysplasia is not known. (moondragon.org)
  • Studies have found a strong association between cervical dysplasia and infection with human papilloma virus (HPV), but additional factors (still unknown) must also be at play in order for cervical cells to change and become precancerous. (moondragon.org)
  • There are concerns about the estrogen found in hormonal contraceptives causing cervical dysplasia. (moondragon.org)
  • Pregnancy: Cases of cervical dysplasia may advance during pregnancy, but treatment can generally be deferred until after delivery. (moondragon.org)
  • A biopsy to diagnose cervical dysplasia is safe to perform during pregnancy. (moondragon.org)
  • Human papilloma virus (HPV) and genital warts have a strong association with cervical dysplasia. (moondragon.org)
  • While there is no established strategy for preventing cervical dysplasia, regular Pap smears are the most effective and reliable method of identifying the condition in its early stages. (moondragon.org)
  • Using condoms helps to prevent the transmission of HPV, a contributing factor in 90-percent of cervical dysplasia cases. (moondragon.org)
  • Use of a diaphragm by the female or a condom by the male for sexual intercourse may offer some protection from cervical dysplasia. (moondragon.org)
  • Human papillomavirus (HPV) infection is the precursor to cervical dysplasia and cancer. (unc.edu)
  • Though the majority of HPV infections are cleared by the body's immune system, cervical dysplasia that persists and progresses to Cervical Intraepithelial Neoplasia 2/3 (CIN 2/3 or moderate/severe dysplasia) requires repeated cytologic screening, biopsies or excisional/ablative therapy. (unc.edu)
  • As a result, providers are compelled to treat women surgically since there are currently no medical therapies to promote the clearance of HPV or cervical dysplasia. (unc.edu)
  • RATIONALE: New diagnostic procedures such as fluorescence and reflectance spectroscopy (shining light on tissue and measuring patterns of light reflected) may improve the ability to noninvasively detect cervical intraepithelial neoplasia and dysplasia. (bioportfolio.com)
  • Identify potential improvements in noninvasive methods of diagnosing dysplasia and neoplasia of the cervix using fluorescence and reflectance spectroscopy in healthy participants with a history of normal pap smears. (bioportfolio.com)
  • PURPOSE: To determine whether the outpatient loop electrosurgical excision procedure (LEEP) conization (out-LEEP) is as effective and safe as inpatient LEEP conization (in-LEEP) with regard to the complete removal of cervical dysplasia, recurrence-free survival and post-operative morbidity. (uzh.ch)
  • We would like to evaluate the efficacy of HPV vaccination in addition to LEEP treatment to prevent residual or recurrent cervical dysplasia and decrease risks of repeated surgical treatment. (eur.nl)
  • Cervical intraepithelial neoplasia (CIN) , also known as cervical dysplasia, refers to abnormal changes in the cells on the surface of the cervix. (diseaseinfosearch.org)
  • Early diagnosis and prompt treatment cures most cases of cervical dysplasia. (diseaseinfosearch.org)
  • Cervical dysplasia is the abnormal growth of the epithelial tissue on the surface of the cervix. (lookfordiagnosis.com)
  • and CIN III -- severe dysplasia to carcinoma-in-situ (cancer localized to the intraepithelial tissue/superficial layer of the cervix). (lookfordiagnosis.com)
  • Less than 5% of all Pap smear tests conducted note cervical dysplasia. (lookfordiagnosis.com)
  • Vaginal Intrapethelial Neoplasia I (VAIN) is the very first stage of vaginal dysplasia, it is very mild, so you caught it early which is great. (lookfordiagnosis.com)
  • It is the women who fail to clear the HPV infection who are at risk for cervical dysplasia and subsequent cervical cancer. (medscape.com)
  • Methods: The aim of the present study is to check the results of the previous one by testing a larger group (43 women affected by cervical dysplasia and 67 healthy women) and by the use of a self-administered test for detection of alexithymia, the well-validated Twenty-Item Toronto Alexithymia Scale (TAS-20). (elsevier.com)
  • A tumor suppressor protein, P16 is biologically tasked with regulating cell cycle progression at the G1/S boundary (8), thus demonstration the value of P16 would be as a diagnostic marker for cervical dysplasia and cervical carcinoma (9). (iranpath.org)
  • The grade of squamous intraepithelial lesion can vary. (wikipedia.org)
  • Cervical intraepithelial neoplasia (CIN) is a pre-cancerous lesion of cervical cancer. (who.int)
  • Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. (who.int)
  • Materials and Methods: We evaluated LBC samples from women referred to gynecology examination for different reasons (previous abnormal PapTest, follow up of treated cervical lesion, ecc) and women examined for regular screening proposals, and compared with biopsy diagnoses, including the controversial diagnoses of vaginal intraepithelial neoplasia (VAIN). (scirp.org)
  • Scapulatempo, C., Fregnani, J.H, Campacci, N., Possati-Resende, J.C., Longatto-Filho, A. and Rodeo Study Team (2013) The Significance of Augmented High-Grade Squamous Intraepithelial Lesion Detection on Pap Test Examination: Partial Results from the RODEO Study Team. (scirp.org)
  • Vaccine efficacy against any lesion (regardless of HPV type) in the generally naive population was 30% (17% to 41%), 75% (22% to 94%), and 48% (10% to 71%) for cervical, vulvar, and vaginal intraepithelial neoplasia grade I, respectively, and 83% (74% to 89%) for condyloma. (bmj.com)
  • The microscopic phenotype of cervical intraepithelial neoplasia (CIN, also referred to as squamous intraepithelial lesion (SIL)) reflects a fine balance between factors that promote or accelerate the development of progressively more advanced disease and factors that reduce or decelerate its progression. (bmj.com)
  • LSIL, low-grade squamous intraepithelial lesion. (bmj.com)
  • Clinically, an unbefitting management for high grade squamous intraepithelial lesion (HSIL) may result from an inaccurate diagnosis by colposcopy bioposy.The study aimed to assess the diagnostic accur. (bioportfolio.com)
  • The methylation of paired box gene 1 (PAX1) has a great influence on the process of cervical lesion. (ovid.com)
  • This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). (eurekamag.com)
  • Approximately 20-40% of high-grade Cervical Intraepithelial Neoplasia (CIN) regresses spontaneously, but the natural prognosis of an individual lesion is unpredictable. (springer.com)
  • The primary study objective is to evaluate the efficacy of the nonavalent HPV vaccination in women with a CIN II-III (high-grade squamous intraepithelial lesion (HSIL) lesion who will undergo a LEEP in preventing recurrent CIN II-III after 24 months. (eur.nl)
  • Co-infection with multiple HPV types could also increase the risk of cervical lesion. (biomedcentral.com)
  • The cytological evaluation showed a high-grade squamous intraepithelial lesion (HSIL/CIN2/3). (medbullets.com)
  • No statistical differences were found in global comparison between cases and controls [odds ratio (OR)=3, p=0.09], nor between well-documented cases of more evolved high-grade squamous cervical intraepithelial lesion versus controls (OR=1.2, p=0.68). (cdc.gov)
  • The presence of E-cadherin-160 C/A was significantly associated with high-grade squamous intraepithelial lesion (HSIL) (OR=2.7916, 95% CI 1.1495,6.9345, x 2 =6.33, p=0.0118) and carcinoma in situ (CIS) (OR=2.5617, 95% CI 1.1676,5.6705, x 2 =6.63, p=0.0100). (cdc.gov)
  • In accordance with new WHO classification, CIN is categorized into Low-Grade Squamous Intraepithelial Lesion (LSIL) and High-Grade Squamous Intraepithelial Lesion (HSIL) terminology (2). (iranpath.org)
  • Researchers have uncovered an increased risk of cervical cancer in women whose cervical cells test positive for certain high-risk human papillomavirus types but do not show any signs of cellular abnormalities. (news-medical.net)
  • The MTHFR 677T allele may enhance the risk of cervical cancer in the Asian female population and play a protective role in Caucasian females. (spandidos-publications.com)
  • Human papillomavirus (HPV) infection of any type was shown to be related to a 498-fold increase in the risk of cervical cancer development. (iranpath.org)
  • In comparison to females infected with HPV-16, patients infected with HPV-18 had a higher risk of cervical cancer. (iranpath.org)
  • Cigarette smoking, both active and passive, increases the risk of cervical cancer. (wikipedia.org)
  • Ho GYF, Kadish RDB, Basu J, Palan PR, Mikhail M and Romney SL (1998a) HPV 16 and cigarette smoking as risk factors for high-grade cervical intra-epithelial neoplasia. (nature.com)
  • After previously reporting the presence of disease by cytology findings after treatment for cervical intra-epithelial neoplasia (CIN) in 64.6% of HIV-infected women and in 13.0% of HIV-negative women, we aimed to determine the severity of cytological disease after treatment in HIV-infected women. (scielo.org.za)
  • However, in patients treated for cervical intra-epithelial neoplasia (CIN), the risk of developing cancer is still 2.8 times greater than in the general population, and may be more in women with recurrent disease. (scielo.org.za)
  • HIV-infected women are at increased risk of cervical intra-epithelial neoplasia (CIN) and invasive cervical cancer (ICC), but it has been difficult to disentangle the influences of heavy exposure to HPV infection, inadequate screening, and immunodeficiency. (uzh.ch)
  • It is the second commonest cancer among women, worldwide, with only breast cancer occurring more commonly [ 1 ], while cervical intra epithelial neoplasia (CIN) is a pre-malignant condition of the cervix. (alliedacademies.org)
  • Susceptibility to human papillomavirus-associated cervical intra-epithelial neoplasia is determined by specific HLA DR-DQ alleles. (semanticscholar.org)
  • Human papillomaviruses (HPV) play a causative role in the aetiology of cervical intra-epithelial neoplasia (CIN) and cervical cancer. (semanticscholar.org)
  • Carbon dioxide laser surgery for cervical intra-epithelial neoplasia. (elsevier.com)
  • The CO 2 laser was used to treat 300 patients with cervical intra-epithelial neoplasia (CIN). (elsevier.com)
  • Fingerprint Dive into the research topics of 'Carbon dioxide laser surgery for cervical intra-epithelial neoplasia. (elsevier.com)
  • This introductory manual is intended to simplify the learning of colposcopy and treatment of cervical intraepithelial neoplasia with cryotherapy and loop electrosurgical excision procedure so as to allow dissemination of the skills in low-resource settings. (who.int)
  • RATIONALE: Diagnostic procedures, such as digital colposcopy, may help doctors find and diagnose cervical intraepithelial neoplasia. (clinicaltrials.gov)
  • PURPOSE: This clinical trial is studying digital colposcopy to see how well it works in finding cervical intraepithelial neoplasia. (clinicaltrials.gov)
  • A. Stafl and G. D. Wilbanks, "An international terminology of colposcopy: report of the nomenclature committee of the International Federation of Cervical Pathology and Colposcopy," Obstetrics and Gynecology , vol. 77, no. 2, pp. 313-314, 1991. (hindawi.com)
  • In this population-based study, women were screened for cervical cancer, and those with cytologic abnormalities and/or who tested positive for cervical HPV DNA were triaged to colposcopy for universal histologic confirmation of cervical disease status. (aacrjournals.org)
  • 188 women were recruited at our colposcopy clinic (out-patient surgery, Department of Obstetrics and Gynecology, Falun Hospital) for laser cervical conization or a directed punch biopsy, either because of a vaginal smear (Pap smear) that showed cytological findings suggesting CIN, or because of repeated findings showing atypical squamous cells of undetermined significance (ASCUS). (diva-portal.org)
  • This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. (eurekamag.com)
  • Every patient had a complete gynecological examination with cervical sampling and colposcopy and TNF-α 308 G/A genotyping. (cdc.gov)
  • Colposcopy and treatment of cervical intraepithelial neoplasia : a beginners' manual / John W. Sellors, R. Sankanarayanan. (who.int)
  • The manual was developed during the implementation of several cervical cancer screening and treatment programmes, and draft versions were used in over 20 training courses on colposcopy and management of cervical precancers in nine different countries in Africa and Asia. (iarc.fr)
  • The book is an A - Z teaching resource in the diagnosis of cervical precancers using colposcopy, and in the treatment of cervical intraepithelial neoplasia using cryotherapy and loop electrosurgical excision procedures. (iarc.fr)
  • Both the presence of cervical pathology and the presence of oral HPV are related to sexual habits. (physiciansweekly.com)
  • We aimed to determine the grade of cervical pathology as reported cytologically in HIV-infected women at least 6 months after local excision compared with the histology findings at the time of treatment, and to assess the factors associated with a lesser grade of disease at follow-up. (scielo.org.za)
  • The concept of manipulation of vaginal bacterial communities using pre- and probiotics is also discussed as an exciting prospect for the field of cervical pathology. (biomedcentral.com)
  • This review will summarise this evidence, discuss possible mechanisms linking vaginal bacteria with cervical pathology and finally consider the potential for future therapeutic strategies. (biomedcentral.com)
  • abstract = 'Treatment of cervical intraepithelial neoplasia (CIN) detectable at screening has helped reduce the incidence of cervical cancer, but has also led to overtreatment. (ku.dk)
  • In contrast to the previously reported study, our results suggest that levels of IGF-I in young women may be inversely associated with HGCIN, a precursor to cervical cancer. (aacrjournals.org)
  • Cervical Intraepithelial Neoplasia (CIN) is a precursor to invasive cervical cancer, which annually accounts for about 3700 deaths in the United States and about 274,000 worldwide. (nih.gov)
  • BACKGROUND: Cervical cancer is caused by Human Papilloma viruses (HPV) and is preceded by precursor stages: Cervical Intraepithelial Neoplasia (CIN). (eur.nl)
  • Cervical cancer, the commonest infection-associated neoplasm, and its premalignant precursor cervical intraepithelial neoplasia (CIN), are caused by strains of the human papillomavirus (HPV). (biomedcentral.com)
  • The Pap smear test has been used widely for the past five decades to understand and screen for early signs of cervical cancer. (news-medical.net)
  • 4), history of abnormal cervical smear test results, and pregnancy. (bmj.com)
  • Despite the advent of the Papanicolaou (Pap) smear, cervical cancers and pre-cancers remain important health problems for women, especially underobserved women in the United States (U.S.) and women in underdeveloped countries (Parkin, 1993). (google.com)
  • Bhattacharyya AK, Nath JD, Deka H. Comparative study between pap smear and visual inspection with acetic acid (via) in screening of CIN and early cervical cancer. (springer.com)
  • Naked eye visual inspection with acetic acid versus cervical smear as a screening test for cervical intraepithelial neoplasia. (alliedacademies.org)
  • A 37-year-old G4P4 woman underwent a routine cervical Pap smear during an annual exam. (medbullets.com)
  • A retrospective study was conducted between 2000 and 2003 on 1620 women [‎mean age 39.6 years]‎ in northern Morocco to determine the incidence of cervical cancer and assess the value of cervical smear in the diagnosis. (who.int)
  • Patients were interviewed using a questionnaire before carrying out a gynaecological examination and taking a cervical smear sample. (who.int)
  • Franklin E, Jenkins R (1973) Prospective studies of the association of genital herpes simplex infection and cervical anaplasia. (springer.com)
  • Human papilloma virus (HPV) infection is necessary for the development of CIN, but not all with this infection develop cervical cancer. (wikipedia.org)
  • Many women with HPV infection never develop CIN or cervical cancer. (wikipedia.org)
  • [3] A large number of women with HPV infection never develop CIN or cervical cancer. (wikipedia.org)
  • Our findings do not support the long-held view that the reason why HPV-18 infection is under-represented at the time of diagnosis of high-grade CIN is because HPV-18-associated disease rapidly progresses through the preinvasive stages of neoplasia. (nih.gov)
  • Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection. (semanticscholar.org)
  • Cervical infection with human papillomavirus (HPV) results in a more permissive environment for malignant transformation. (nih.gov)
  • In this case-control study, we investigated plasma levels of IGF-I and IGFBP-3 in relation to the risk of histologically confirmed high-grade cervical intraepithelial neoplasia (HGCIN) and the risk of human papillomavirus (HPV) infection. (aacrjournals.org)
  • Human papillomavirus (HPV) infection is now considered a necessary cause in the development of cervical cancer ( 1 ). (aacrjournals.org)
  • However, only a small percentage of women who are infected with HPV infection go on to develop cervical cancer or its precursors ( 2 ). (aacrjournals.org)
  • A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection," The New England Journal of Medicine , vol. 327, no. 18, pp. 1272-1278, 1992. (hindawi.com)
  • Persistent cervical mucosal infection with oncogenic strains of human papillomavirus (HPV), most commonly type 16, is the cause of virtually all squamous cancers of the cervix ( 1 , 2 ). (jimmunol.org)
  • Human papillomavirus (HPV) has been associated with cervical intraepithelial neoplasia, but the temporal relation between the infection and the neoplasia remains unclear, as does the relative importance of the specific type of HPV, other sexually transmitted diseases, and other risk factors. (uni-bonn.de)
  • After adjustment for the presence of HPV infection, the development of cervical intraepithelial neoplasia was also associated with younger age at first intercourse, the presence of serum antibodies to Chlamydia trachomatis, the presence of serum antibodies to cytomegalovirus, and cervical infection with Neisseria gonorrhoeae. (uni-bonn.de)
  • Cervical intraepithelial neoplasia is a common and apparently early manifestation of cervical infection by HPV, particularly types 16 and 18. (uni-bonn.de)
  • The risk for the development of cervical cancer is enhanced through infection by human papillomavirus (HPV). (spandidos-publications.com)
  • However, infection with HPV alone is not sufficient for the development of this type of cancer, since several additional host factors may affect the persistence of HPV infection, which induces the malignant conversion of cervical epithelial cells ( 3 - 8 ). (spandidos-publications.com)
  • The aim of this research was to study the correlation between tissue tumor marker expression and HR-HPV infection, smoking, hormonal contraceptive use and sex steroids in women with cervical intraepithelial neoplasia or normal epithelium. (diva-portal.org)
  • The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia (CIN). (who.int)
  • Several epidemiological studies make it possible to conclude that persistent infection by certain types of HPV is a causal and necessary factor for the development of cervical cancer. (biomedcentral.com)
  • Women with abnormal cervical cells were enrolled and classified by histological diagnosis and hrHPV infection. (biomedcentral.com)
  • Among 252 women diagnosed with normal cervical epithelium, with regard to LINE-1 methylation level no significant difference was observed between hrHPV positive and hrHPV negative women, also adjusting for known risk factors of infection. (biomedcentral.com)
  • The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next? (biomedcentral.com)
  • Persistence of the virus is essential for development of high-grade CIN and cervical cancer and factors that correlate with higher persistence rates include age, immunodeficiency, smoking, oral contraceptives and Chlamydia trachomatis infection. (biomedcentral.com)
  • The relation between human immunodeficiency virus (HIV), human papilloma virus (HPV) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (CIN) has been analyzed in a cross- sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the Colposcopic Unit of the Ospedale Luigi Sacco of Milan and women consecutively admitted to the Community for Past Drug Abusers, S. Patrignano, Rimini. (elsevier.com)
  • Infection with some types of HPV is the greatest risk factor for cervical cancer, followed by smoking. (wikipedia.org)
  • Infection with HPV is generally believed to be required for cervical cancer to occur. (wikipedia.org)
  • The majority of these changes occur at the squamocolumnar junction, or transformation zone, an area of unstable cervical epithelium that is prone to abnormal changes. (wikipedia.org)
  • Study Design: One-hundred ninety-five women of fertile age with cervical biopsies ranging histologically from normal epithelium to carcinoma in situ were recruited consecutively. (diva-portal.org)
  • The study investigated the expression of 11 tumor markers in cervical biopsies obtained from 228 women with different diagnoses ranging from normal cervical epithelium to various stages of CIN. (diva-portal.org)
  • For 40 volunteers, punch biopsies were taken from the normal cervical epithelium. (diva-portal.org)
  • 230 images digitally captured from cases previously classified by a gynaecological pathologist included normal cervical squamous epithelium (n = 30), koilocytosis (n = 46), CIN 1 (n = 52), CIN 2 (n = 56), and CIN 3 (n=46). (qub.ac.uk)
  • E-cadherin is a transmembrane glycoprotein with important roles in the maintenance of cervical squamous epithelium integrity. (cdc.gov)
  • The areas where P63, a member of the P53 gene family, is expressed include the basal and parabasal cells of mature cervical, vaginal and vulvar squamous epithelium, as well as cervical reserve cells at the transformation zone, immature metaplastic cells, and atrophic cervical squamous epithelium. (iranpath.org)
  • Ferenczy A, Richart RM, Okagaki T (1971) Endometrial involvement by cervical carcinoma in situ. (springer.com)
  • The incidence of both invasive cervical cancer and carcinoma-in-situ are increasing in the U.S. The reasons for this increase are unknown. (google.com)
  • Fidler HK, Boyes DA, Nichols TM, Worth AJ (1970) Cervical cytology in the control of cancer of the cervix. (springer.com)
  • Harper JM, Levine AJ, Rosenthal DL, Wiesmeier E, Hunt IF, Swendseid ME and Haile RW (1994) Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology. (nature.com)
  • Vaginal Intraepithelial Neoplasia Detected with Cervical Liquid-Based Cytology: Old Concerns or New Facilities? (scirp.org)
  • 2008) Cytologic Detection of Cervical Abnormalities Using Liquid-Based Compared with Conventional Cytology: A Randomized Controlled Trial. (scirp.org)
  • 2008) Liquid Compared with Conventional Cervical Cytology: A Systematic Review and Meta-Analysis. (scirp.org)
  • 2007) Accuracy of Liquid Based versus Conventional Cytology: Overall Results of New Technologies for Cervical Cancer Screening: Randomised Controlled Trial. (scirp.org)
  • Compared with triennial cytology, annual cytology follow-up reduced expected cervical cancer deaths by 73% to 77% and had an average incremental cost per life-year gained of $69,000 to $81,000. (sanevax.org)
  • CONCLUSION: Annual conventional cytology surveillance reduced cervical cancers and cancer deaths compared with triennial cytology. (sanevax.org)
  • High-risk human papillomavirus (HPV) DNA/RNA testing provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN). (asm.org)
  • Seven of the 17 with CIN had no abnormality on cervical cytology. (bmj.com)
  • The large number of false negative results on cervical cytology in our patients suggests that women presenting with vulval warts should be screened colposcopically in the first instance. (bmj.com)
  • The primary outcome will be residual/recurrent disease defined as abnormal histology or cytology of any grade, while secondary outcomes will include treatment failure rates defined as high-grade histology or cytology, histologically confirmed CIN1+ or histologically confirmed CIN2+, human papillomavirus positivity rates, involved margins rates, bleeding and cervical stenosis rates. (lse.ac.uk)
  • Accuracy of concurrent visual and cytology screening in detecting cervical cancer precursors in rural India. (springer.com)
  • To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. (uky.edu)
  • To evaluate the use of naked eye visual inspection with acetic acid (VIA) as an alternative to cervical cytology as a screening test for diagnosis of cervical intraepithelial neoplasia. (alliedacademies.org)
  • Background: The detection of vaginal intraepithelial neoplasia (VAIN) in cervical samples is not a common finding. (scirp.org)
  • 1997) Vaginal Intraepithelial Neoplasia: Risk Factors for Persistence, Recurrence, and Invasion and Its Management. (scirp.org)
  • 1991) Natural History of Vaginal Intraepithelial Neoplasia. (scirp.org)
  • 2005) Upper Vaginectomy for the Treatment of Vaginal Intraepithelial Neoplasia. (scirp.org)
  • Boonlikit, S. and Noinual, N. (2010) Vaginal Intraepithelial Neoplasia: A Retrospective Analysis of Clinical Features and Colpohistology. (scirp.org)
  • 1995) Epidemiological Aspects of Vaginal Intraepithelial Neoplasia (VAIN). (scirp.org)
  • Main outcome measures Vaccine efficacy against cervical, vulvar, and vaginal intraepithelial neoplasia grade I and condyloma in a per protocol susceptible population that included subjects who received all three vaccine doses, tested negative for the relevant vaccine HPV types at day 1 and remained negative through month 7, and had no major protocol violations. (bmj.com)
  • Conversely 40-60% of patient with vulval intraepithelial neoplasia (VIN) or vaginal intraepithelial neoplasia (VAIN) have synchronous CIN [ 3 ]. (alliedacademies.org)
  • A comprehensive analysis of eight clinical trials and four cohort studies on cervical cancer screening by researchers from UC Davis and Kaiser Permanente Northwest has found that while Pap smears are still highly effective for detecting pre-cancerous cells and cancer, testing for the virus that causes these cancers also is an excellent screening tool. (news-medical.net)
  • Hildesheim A, Reeves WC, Brinton LA, Lavery C, Brenes M, De-La Guardia ME, Godoy J and Rawls WE (1990) Association of oral contraceptive use and human papillomaviruses in invasive cervical cancers. (nature.com)
  • The quadrivalent HPV vaccine (for types 6, 11, 16, and 18) has the potential to prevent about 70% of cervical cancers 15 and 90% of condyloma 9 13 by targeting HPV types 16 and 18 and types 6 and 11, respectively. (bmj.com)
  • Particularly worth mentioning is the fact that the addition of HPV-52 and -58 to the vaccine cocktail would increase cancer protection in our population, potentially preventing up to beyond 16% of squamous/adenosquamous carcinoma and other type of cervical cancers, and 7.75% of adenocarcinomas. (mdpi.com)
  • A significant higher incidence of some cancers, especially lung cancer, has been found in women with previous HPV-related (human papillomavirus) urogenital and anal neoplasias than in individuals without this particular clinical history. (sanevax.org)
  • World-wide, cervical cancer comprises 12% of all cancers in women [ 5 ]. (alliedacademies.org)
  • [ 6 ] Because HPV is implicated in such a high percentage of cervical cancers, a great deal of research has been devoted to characterizing the virus and its role in cervical cancer. (medscape.com)
  • they are found in 99% of cervical cancers, with types 16 and 18 being found in 70% of them. (medscape.com)
  • HPV vaccines protect against two to seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. (wikipedia.org)
  • About 70% of cervical cancers and 90% of deaths occur in developing countries. (wikipedia.org)
  • These biological events might be involved in epidemiological correlations found between hormonal contraceptive use and cervical neoplasms. (diva-portal.org)
  • Cervical screening for the early identification and treatment of cervical intraepithelial neoplasia has reduced the incidence and mortality from cervical cancer. (bmj.com)
  • Cervical cancer screening and treatment of cervical intraepithelial neoplasia in female sex workers using "screen and treat" approach. (springer.com)
  • As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. (bmj.com)
  • Risk factors in the development of cervical intraepithelial neoplasia in women with vulval warts. (bmj.com)
  • Methods for treating, preventing, controlling the growth of and/or reducing the risk of developing cervical cancer, particularly in patients with cervical intraepithelial neoplasia are provided employing pharmaceutically acceptable preparations of DFMO. (google.com)
  • LITERATURE REVIEW: In the most recent set of algorithms, the 2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors, the authors conclude that there is high-level evidence to support extended screening intervals for women who are at average-risk for cervical cancer and who have a history of negative screening tests. (bu.edu)
  • SIGNIFICANCE: Determining the risk of recurrent disease in women with abnormal cervical cancer screening tests will serve to more optimally manage this cohort of women. (bu.edu)
  • The diagnosis of CIN or cervical carcinoma requires a biopsy for histological analysis. (wikipedia.org)
  • Treatment options for high-grade cervical intraepithelial neoplasia include procedures that destroy the abnormal cells (like cryosurgery or laser), and procedures that remove the abnormal tissue (like LEEP, cone biopsy, or hysterectomy). (oncolink.org)
  • HPV viral replication within cells causes a range of cellular changes seen microscopically in cervical biopsy specimens. (aacrjournals.org)
  • A retrospective analysis on 1901 women with high grade cervical intraepithelial neoplasia by colposcopic biopsy. (bioportfolio.com)
  • In positive cases, colposcopic-guided cervical biopsy and histopathological studies are done and the pathological findings are reported. (springer.com)
  • Cervical intraepithelial neoplasia grade 2 or 3 was confirmed by biopsy in 28 women. (uni-bonn.de)
  • All the positive acetowhite (85) and 20 negative acetowhite randomly selected and underwent cervical biopsy and histopathology. (alliedacademies.org)
  • Diagnosis is typically by cervical screening followed by a biopsy. (wikipedia.org)
  • A new study reveals inequalities in the delay in screening for cervical cancer, and recommends that the screening capacity be increased in addition to giving a higher priority to women who have missed their scheduled visit. (news-medical.net)
  • A new method of cervical cancer screening which is designed to be done by women at home could bring down the rates of cervical cancer and associated deaths. (news-medical.net)
  • A single test for women has been shown to aid in predicting which cases of precancerous cervical disease will become more serious, helping with decisions on whether or not surgery is needed, according to a study led by Queen Mary University of London. (news-medical.net)
  • This manual will help to equip health care providers with the necessary skills in detecting and treating cervical intraepithelial neoplasia, thereby preventing invasive cervical cancer in many women throughout the world. (who.int)
  • The human leukocyte antigen (HLA)- DRB1*13 allele frequency is lower in women with cervical carcinoma than in the general population, suggesting that this allele could exert a protective effect against progression of cervical intraepithelial neoplasia (CIN) associated with human papillomaviruses (HPV). (lww.com)
  • Randomised controlled trials (RCTs) of alternative surgical treatments in women with cervical intraepithelial neoplasia. (who.int)
  • Eligibility criteria Studies assessing fertility and early pregnancy outcomes in women with a history of treatment for cervical intraepithelial neoplasia versus untreated women. (bmj.com)
  • 9.8% v 8.4%, 1.16, 0.80 to 1.69) was similar for treated and untreated women, cervical treatment was associated with a significantly increased risk of miscarriage in the second trimester. (bmj.com)
  • Cuzick J, Singer A, De-Stavola BL and Chomet J (1990b) Case-control study of risk factors for cervical intraepithelial neoplasia in young women. (nature.com)
  • Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women. (semanticscholar.org)
  • HPV testing can reduce the number of follow-up visits in women treated for cervical intraepithelial neoplasia grade 3. (semanticscholar.org)
  • It is estimated that 30 million women and men acquire anogenital warts (condyloma acuminata) or low grade cervical intraepithelial neoplasia each year, 2 which may be an underestimation given the inadequacy of reporting in many countries and evidence of a rising incidence over time. (bmj.com)
  • It also suggests that quantification of HPV-16 E6-E7 transcription may be useful as a prognostic tool to identify women who are at increased risk of developing cervical cancer. (nih.gov)
  • Current research strives to determine why certain HPV-positive women develop cervical cancer while others do not. (aacrjournals.org)
  • Cervical cancer is the third most frequent neoplasm in Brazilian women (estimated risk of 15.33 cases / 100,000 women by 2014), behind breast and colorectal cancer. (centerwatch.com)
  • Current vaccines may provide some protection for women from cervical carcinoma linked to HPV genotype 16 and 18. (mdpi.com)
  • This study provided an observational, retrospective, hospital-based cross-sectional study on the distribution of HPV genotypes among 5410 women with invasive cervical cancer (ICC) or cervical intraepithelial neoplasia (CIN). (mdpi.com)
  • Methods: A total of 2,055 women positive for high-risk human papillomavirus, with a minimum of five cervical biopsies, were enrolled in the Shanxi Province Cervical Cancer Screening Study II. (aacrjournals.org)
  • No differences in sexual behaviour, smoking habit, or oral contraceptive use were seen between women with CIN and those with no cervical abnormality. (bmj.com)
  • Close follow up of women whose warts are treated and who are thought to have no cervical abnormality at that assessment is essential. (bmj.com)
  • Cervical cancer is the second most common cancer among women. (springer.com)
  • We studied prospectively a cohort of 241 women who presented for evaluation of sexually transmitted disease and had negative cervical cytologic tests. (uni-bonn.de)
  • On the basis of survival analysis, the cumulative incidence of cervical intraepithelial neoplasia at two years was 28 percent among women with a positive test for HPV and 3 percent among those without detectable HPV DNA. (uni-bonn.de)
  • All 24 cases of cervical intraepithelial neoplasia grade 2 or 3 among HPV-positive women were detected within 24 months after the first positive test for HPV. (uni-bonn.de)
  • Prevalence of human papillomavirus in the saliva of sexually active women with cervical intraepithelial neoplasias. (physiciansweekly.com)
  • The main objective of this study was to estimate the prevalence of human papillomavirus-DNA (HPV-DNA) in the saliva of sexually active women with HPV-related cervical intraepithelial neoplasias (CIN) and compare the findings with a healthy control group. (physiciansweekly.com)
  • 4 The national screening programme for the prevention of cervical cancer in SA started in 2001 and was based on data pertaining to HIV-negative women. (scielo.org.za)
  • We aimed to assess whether the cervical disease that occurs in HIV-infected women after treatment is of a different grade of disease compared with the histology results at presentation. (scielo.org.za)
  • Methods: Fresh cervical punch biopsies from 20 women were incubated in RPMI1640 medium for 24 hours at 4°C for protein extraction and subsequently subjected to standard FFPE processing. (uib.no)
  • These women have a lifelong increased risk of recurrent CIN, cervical cancer and other HPV related malignancies. (eur.nl)
  • Cervical cancer is the second most common cancer in women worldwide. (biomedcentral.com)
  • The aim of the present study was to investigate the degree of WBCs LINE-1 methylation, according to high-risk Human Papilloma Virus (hrHPV) status in a healthy population, and the association with high-grade Cervical Intraepithelial Neoplasia (CIN2+) in hrHPV positive women. (biomedcentral.com)
  • Worldwide, cervical cancer is the second commonest cancer among women. (alliedacademies.org)
  • Approximately 10% of women with CIN have concomitant pre invasive neoplasia of the vulva, vagina or anus. (alliedacademies.org)
  • These changes in the cervical cells can develop at any age, but they are most common in women ages to 25-35. (diseaseinfosearch.org)
  • It is estimated that 50% of women diagnosed with invasive cervical cancer have never had a Papanicolaou test, and 10% have not had a Papanicolaou test in the 5 years prior to diagnosis. (medscape.com)
  • Einstein, Mark H. / Outcomes after an excisional procedure for cervical intraepithelial neoplasia in HIV-infected women . (elsevier.com)
  • Objective To determine the involvement of cervical intraepithelial neoplasia grade 3 (CIN3) in a population of women in a lower-resource setting. (elsevier.com)
  • We have recently addressed this concern by demonstrating that higher plasma folate concentrations were not associated with greater risk of being diagnosed with higher grades of cervical intraepithelial neoplasia (CIN 2+) especially in women with sufficient plasma vitamin B12 concentrations . (uab.edu)
  • About six women have undergone CIN treatment for each prevented cervical cancer. (ku.dk)
  • The frequency of CIN treatment increased after 2004 and at present almost eight women are treated per prevented cervical cancer case. (ku.dk)
  • BACKGROUND: Cervical cancer has historically been a major cause of mortality for women worldwide. (bu.edu)
  • PROPOSED PROJECT: This thesis proposes a systematic literature review of the existing evidence regarding to what extent women who are treated for cervical abnormalities at baseline are at an increased risk for persistent or recurrent disease in the future. (bu.edu)
  • Worldwide, cervical cancer is both the fourth-most common cause of cancer and the fourth-most common cause of death from cancer in women. (wikipedia.org)
  • Smoking can increase the risk in women a few different ways, which can be by direct and indirect methods of inducing cervical cancer. (wikipedia.org)
  • Fidler HK, Boyes DA, Worth AJ (1968) Cervical cancer detection in British Columbia. (springer.com)
  • Early detection of CIN is important to reduce the fatalities due to cervical cancer. (nih.gov)
  • Challenges in Automated Detection of Cervical Intraepithelial Neoplasia Proc SPIE Medical Imaging 2007. (nih.gov)
  • Such early detection is key to preventing the condition from progressing to cervical cancer. (moondragon.org)
  • Early detection of cervical cancer with visual inspection methods: a summary of completed and on-going studies in India. (springer.com)
  • Cytokeratin-17 (CK17), which is an efficient marker for detection of cervical stem cells, is expressed in reserve cells and immature metaplastic cells. (iranpath.org)
  • The literature dealing with the natural history of cervical intraepithelial neoplasia (CIN) since 1950 is reviewed, in particular from the viewpoint of regression, persistence, and progression. (nih.gov)
  • Consequently, the classification of cervical cancer precursors may need revision to more accurately reflect the natural history of disease progression and to inform clinical decision making ( 1 ). (aacrjournals.org)
  • More specifically, the present invention provides a composition comprising alpha-difluoromethylornithine for treating, preventing, reducing the risk of and/or controlling the growth and progression of cervical intraepithelial neoplasia grade III into malignancy. (google.com)
  • Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as "high grade", in spite of their different risk to cancer progression and spontaneous regression rates. (uib.no)
  • Burghart E (1973) Early Histological Diagnosis of Cervical Cancer, 1st ed. (springer.com)
  • Hamilton, Peter W. / An automated machine vision system for the histological grading of cervical intraepithelial neoplasia (CIN) . (qub.ac.uk)
  • HLA-A, HLA-B, HLA-DRB1 polymorphisms and risk of cervical squamous epithelial cell carcinoma: a population study in China. (semanticscholar.org)
  • Human papillomaviruses (HPVs) are responsible for about 500 000 cases of cervical cancer a year globally 1 and 10 million further cases of high grade cervical intraepithelial neoplasias (grades II or III), 2 immediate precursors to malignancy. (bmj.com)
  • Low risk of type-specific carcinogenic HPV re-appearance with subsequent cervical intraepithelial neoplasia grade 2/3. (semanticscholar.org)
  • High-risk human papillomaviruses (hrHPVs) are causally related to cervical intraepithelial neoplasia (CIN) and subsequent cervical cancer (CC). The vaginal microbiome has been suggested to play a role in the development of CC, but the effect of conservative surgical treatment on the microbiome and hrHPV elimination has not been elucidated. (frontiersin.org)
  • As part a Program Project to evaluate emerging optical technologies for cervical neoplasia, our group is performing quantitative histopathological analysis of biopsies from 1800 patients. (hindawi.com)
  • Conclusions: 114 proteins were identified in supernatants from fresh cervical biopsies and many differed between CIN2 and 3. (uib.no)
  • This study shows that automated location of nuclei in cervical biopsies using computerized image analysis is possible. (qub.ac.uk)
  • In most cervical carcinomas, human papillomavirus (HPV) genomes are integrated into host cell chromosomes and transcribed into mRNAs encompassing viral and cellular sequences. (aacrjournals.org)
  • As our study shows the current tetravalent vaccine could be effective in our geographical area for preventing all the invasive cervical carcinomas. (biomedcentral.com)
  • Worldwide, the human papillomavirus (HPV) has been detected in as many as 99.7% of cervical carcinomas. (medscape.com)
  • Nevertheless, CIN II and CIN III were considered as precursors to invasive carcinomas and therapy (conization or other less invasive procedures) was indicated since 0.2% to 4.0% of cases with CIN II and CIN III can progress to cervical carcinoma within 12 months (4). (iranpath.org)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • Most neoplasias of the uterine cervix are associated with specific types of human papillomaviruses (HPV). (lww.com)
  • Introduction: Local treatments for cervical intraepithelial neoplasia (CIN) and microinvasive disease remove or ablate a cone-shaped part of the uterine cervix containing the abnormal cells. (lse.ac.uk)
  • Samples of uterine cervix that were diagnosed as containing cervical intraepithelial neoplasia (CIN) I-III or carcinoma were examined and compared with samples of normal uterine cervix. (aacrjournals.org)
  • The most common cervical screening test used worldwide was developed by Dr. George Papanicolaou in 1943 when he described how vaginal cells could be collected and stained as a means of detecting cytologic abnormalities of the uterine cervix. (medscape.com)
  • Cervical cancer, which is also of epithelial origin, has been shown to overexpress receptors for IGF-I, and plasma levels of IGF-I have been positively associated with cervical cancer precursors in one epidemiologic study. (aacrjournals.org)
  • To study the presence of cervical intraepithelial neoplasia (CIN) in diabetic patients attending the outpatient clinic of obstetrics and gynecology department in Mansoura University Hospitals using visual inspection with acetic acid test (VIA). (springer.com)
  • While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer. (wikipedia.org)
  • The purpose of this prospective study is to evaluate whether DNA methylation can be applied in cervical cancer screening. (centerwatch.com)
  • The present invention provides a pharmaceutical formulation and a method for its use in the prevention of cervical cancer. (google.com)
  • Epidemiologic classification of human papillomavirus types associated with cervical cancer," The New England Journal of Medicine , vol. 348, no. 6, pp. 518-527, 2003. (hindawi.com)
  • Adequate screening and appropriate treatment reduces the incidence of cervical cancer in developed countries. (scielo.org.za)
  • In the United States, the incidence of cervical cancer fell approximately 70% from 1950-1970, followed by an additional 50% drop from 1970-2000. (medscape.com)
  • Screening, though effective in reducing the incidence of cervical cancer, leads also to a considerable burden of CIN treatment. (ku.dk)
  • Over the last 50 years, thanks to advances in screening technologies and the implementation of standardized management algorithms, the incidence of cervical cancer in the United States has been declining. (bu.edu)
  • Treatment with cervical conization may adversely affect fertility. (moondragon.org)
  • Vaccination against the human papilloma virus (HPV) reduces the risk of a condition that often leads to cervical cancer, according to an analysis of Danish health registry data. (news-medical.net)
  • An analysis of cervical precancers over a period of seven years showed that two strains of human papillomavirus that have been targeted by vaccination since 2006 have declined, accounting for a smaller proportion of cervical disease. (news-medical.net)
  • The human papilloma virus can cause cervical cancer. (news-medical.net)
  • Burger MPM, Hollema H, Gouw ASH, Pieters WJLM and Quint WGV (1993) Cigarette smoking and human papillomavirus in patents with reported cervical cytological abnormality. (nature.com)
  • Cuzick J, Terry G, Ho L, Hollingworth T and Anderson M (1994) Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia. (nature.com)
  • Eluf-Neto J, Booth M, Munoz N, Bosch FX, Meijer CJLM and Walboomers JMM (1994) Human papillomavirus and invasive cervical cancer in Brazil. (nature.com)
  • Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study. (semanticscholar.org)
  • The role of mucosal immunity in human papillomavirus (HPV)-related cervical diseases is poorly understood. (semanticscholar.org)
  • Objectives To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). (bmj.com)
  • Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. (bmj.com)
  • Human papillomavirus (HPV) are firmly established as the principal causative agent for cervical carcinoma. (mdpi.com)
  • T-Cell proliferative response to human papillomavirus type 16 peptides: relationship to cervical intraepithelial neoplasia," Clinical and Diagnostic Laboratory Immunology , vol. 3, no. 2, pp. 205-210, 1996. (hindawi.com)
  • High-risk (HR) human papillomavirus (HPV) is a necessary factor for the development of cervical cancer ( 31 ), but the presence of HR HPV DNA does not invariably lead to disease. (asm.org)
  • The association between 3q gain and cervical oncogenesis may be caused by amplification of the human telomerase RNA gene ( hTERC ), which is localized on the 3q26 locus. (springer.com)
  • The human papillomavirus (HPV) causes both cervical intraepithelial neoplasia (CIN) and cervical cancer. (biomedcentral.com)
  • This will allow providers to effectively monitor patients for the recurrence of cervical disease, while also minimizing the risks associated with overscreening. (bu.edu)
  • A non-invasive test to detect cervical pre-cancer could increase participation rates in cervical cancer screening programs. (news-medical.net)
  • Generally, signs and symptoms of cervical cancer include: abnormal or post-menopausal bleeding abnormal discharge changes in bladder or bowel function pelvic pain on examination abnormal appearance or palpation of cervix. (wikipedia.org)
  • Nooh AM, Mohamed MES, El-Alfy Y. Visual inspection of cervix with acetic acid as a screening modality for cervical cancer. (springer.com)
  • AIM: To determine the frequency of cervical intraepithelial neoplasia (CIN) following large loop excision of the transformation zone of the cervix (LLETZ) according to grade and completeness of excision of CIN. (bmj.com)
  • However, simple visual inspection of the cervix after application of acetic acid has been effectively used in resource-poor settings for cervical cancer screening. (alliedacademies.org)
  • Cervical intraepithelial neoplasia, or CIN, is the abnormal growth of precancerous cells in the cervix. (lookfordiagnosis.com)
  • The widespread utilization of routine cervical cancer screening has greatly enhanced physicians' ability to detect cancer ous and precancerous changes of the cervix. (medscape.com)
  • Cervical cancer is a cancer arising from the cervix. (wikipedia.org)
  • Regression of Low-Grade Cervical Intraepithelial Neoplasia i. (lww.com)
  • However, in cross-sectional studies, HPV-18 is rarely detected at the time of diagnosis of high-grade cervical intraepithelial neoplasia (CIN). (nih.gov)
  • Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy. (semanticscholar.org)
  • 7 8 9 Cervical intraepithelial neoplasia grade I can contain a variety of low or high risk HPV types, 10 11 12 whereas anogenital warts are (in up to 90% of cases) caused by either of two low risk HPV types-namely, 6 and 11. (bmj.com)
  • OBJECTIVE: To estimate outcomes and costs of surveillance strategies after treatment for high-grade cervical intraepithelial neoplasia (CIN). (sanevax.org)
  • Although CIN was initially described as a continuum of histologic changes (all of which were considered true precursors of invasive disease if untreated) ( 1 ), more recent data on the natural history of cervical neoplasia have since been revised to acknowledge that CIN does not always inevitably progress through each higher grade of CIN to cancer ( 1 , 2 ). (aacrjournals.org)
  • Patients with completely excised high grade CIN require careful cervical cytologic surveillance. (bmj.com)
  • Cervical intraepithelial neoplasia grade 2 (CIN2) frequently regresses, is typically slow-growing, and rarely progresses to cancer. (aacrjournals.org)
  • To determine whether Curcuma longa Linn extract, NBFR-03, can arrest low-grade squamous intraepithelial neoplasia (LSIL) a 12 week intervention study was performed. (waocp.org)
  • Histopathological findings were consistent with villoglandular papillary adenocarcinoma associated with high grade cervical intraepithelial neoplasia (CIN-3). (manipal.edu)