CeruloplasminCopper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Hepatolenticular Degeneration: A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.Iron Metabolism Disorders: Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)Metal Metabolism, Inborn ErrorsIron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.Lymphangiectasis: A transient dilatation of the lymphatic vessels.Deficiency Diseases: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)Turpentine: The concrete oleoresin obtained from Pinus palustris Mill. (Pinaceae) and other species of Pinus. It contains a volatile oil, to which its properties are due, and to which form it is generally used. (Dorland, 28th ed) Turpentine is used as a solvent and an experimental irritant in biomedical research. Turpentine toxicity is of medical interest.AnserineHaptoglobins: Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.Cation Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.Apoproteins: The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).Copper Sulfate: A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Macroglobulins: Serum globulins with high molecular weight. (Dorland, 28th ed)National Academy of Sciences (U.S.): A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Institute of Medicine (U.S.): Identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.Neuropsychology: A branch of psychology which investigates the correlation between experience or behavior and the basic neurophysiological processes. The term neuropsychology stresses the dominant role of the nervous system. It is a more narrowly defined field than physiological psychology or psychophysiology.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Ferritins: Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.Apoferritins: The protein components of ferritins. Apoferritins are shell-like structures containing nanocavities and ferroxidase activities. Apoferritin shells are composed of 24 subunits, heteropolymers in vertebrates and homopolymers in bacteria. In vertebrates, there are two types of subunits, light chain and heavy chain. The heavy chain contains the ferroxidase activity.Microspheres: Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Prothrombin: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.Rats, Inbred LEC: A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. This strain is a model for Wilson's Disease (see HEPATOLENTICULAR DEGENERATION).Military Medicine: The practice of medicine as applied to special circumstances associated with military operations.Lawsonia Plant: A plant genus of the family LYTHRACEAE that is the source of henna and has cytotoxic activity.Cucumis: A plant genus of the family CUCURBITACEAE, order Violales, subclass Dilleniidae best known for cucumber (CUCUMIS SATIVUS) and cantaloupe (CUCUMIS MELO). Watermelon is a different genus, CITRULLUS. Bitter melon may refer to MOMORDICA or this genus.Coriandrum: A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.Abelmoschus: A plant genus of the family MALVACEAE, order Malvales, subclass Dilleniidae best known for okra.Gene Targeting: The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Magnetocardiography: The measurement of magnetic fields generated by electric currents from the heart. The measurement of these fields provides information which is complementary to that provided by ELECTROCARDIOGRAPHY.Forensic Genetics: The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Lactation: The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.Mammary Neoplasms, Animal: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Acute-Phase Proteins: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase antibodies. (1/796)

BACKGROUND: The purpose of this study was to characterize the recently reported inhibition of myeloperoxidase (MPO) by ceruloplasmin and to determine whether this may be disturbed in the presence of anti-MPO antibodies. METHODS: Specificity of the binding between ceruloplasmin and MPO was confirmed by Western blotting and enzyme-linked immunosorbent assay (ELISA), and the enzymatic activity of MPO was measured in the presence of ceruloplasmin, affinity-purified anti-MPO antibodies, or both. The affinity of the binding between MPO and ceruloplasmin and MPO and the anti-MPO antibodies was measured using a biosensor, with the results confirmed by chaotrope ELISA. RESULTS: Affinity-purified anti-MPO antibodies from patients with microscopic polyangiitis and florid renal vasculitis inhibited the binding between ceruloplasmin and MPO to a maximum of 72.9 +/- 12.8%, whereas those from patients with Wegener's granulomatosis and only minimal renal involvement inhibited the binding to a maximum of only 36.8 +/- 10.9% (P < 0. 001), with comparable reversal of the ceruloplasmin-mediated inhibition of MPO activity. Measurement of the affinity of the interactions demonstrated that binding between MPO and the anti-MPO antibodies is stronger than that between MPO and ceruloplasmin (1.61 x 107 to 1.33 x 108 vs. 7.46 x 106 m-1), indicating that binding to the autoantibody would be favored in vivo. CONCLUSIONS: This study confirms a role for ceruloplasmin as a physiological inhibitor of MPO, and demonstrates how the inhibition may be disrupted in the presence of anti-MPO antibodies. Because a majority (16 of 21) of the antibodies did not themselves inhibit MPO activity, their interference with the inhibition mediated by ceruloplasmin may be brought about by steric hindrance consequent upon the binding of the antibody to a dominant epitope at or near the active site.  (+info)

Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation. (2/796)

It is widely accepted that iron deposition in the iron storage protein ferritin in vitro involves Fe(II) oxidation, and that ferritin facilitates this oxidation at a ferroxidase site on the protein. However, these views have recently been questioned, with the protein ferroxidase activity instead being attributed to autoxidation from the buffer alone. Ligand exchange between another protein with ferroxidase activity and ferritin has been proposed as an alternative mechanism for iron incorporation into ferritin. In the present work, a pH stat apparatus is used to eliminate the influence of buffers on iron(II) oxidation. Here we show that the recent experiments questioning the ferroxidase activity of ferritin were flawed by inadequate pH control, that buffers actually retard rather than facilitate iron(II) oxidation, and that horse spleen ferritin has ferroxidase activity when measured under proper experimental conditions. Furthermore, high pH (7.0), a high Fe(II) concentration and the presence of Fe(III) all favour Fe(II) autoxidation in the presence or absence of ferritin.  (+info)

Copper metabolism in retinitis pigmentosa. (3/796)

Clinically and electrophysiologically confirmed cases of primary retinitis pigmentosa have been investigated regarding their copper metabolic state. It is observed that these patients show a normal or near normal serum copper concentration, very low plasma caeruloplasmin concentration, and a very high copper urinary excretion. A similarity between this condition and hepatolenticular degeneration is drawn and it is suggested that retinitis pigmentosa may also be a condition caused by an inborn error of copper metabolism.  (+info)

Caeruloplasmin isoforms in Wilson's disease in neonates. (4/796)

AIM: To investigate the neonatal diagnosis of Wilson's disease from caeruloplasmin isoforms in cord blood. METHODS: Serum caeruloplasmin isoforms were measured in 5-10 ml cord blood from 10 fresh umbilical cords using sodium dodecyl polyacrylamide gel electrophoresis (SDS PAGE) and western blotting and analysed by densitometry. Total caeruloplasmin concentrations were determined by nephelometry and caeruloplasmin oxidase by p-nitrophenyldiamine. RESULTS: Although total caeruloplasmin concentrations are reduced in neonates, the plasma isoform was significantly reduced or absent in patients with Wilson's disease. Sera from healthy neonates and from those with Wilson's disease had reduced biliary isoforms. CONCLUSION: Identification of caeruloplasmin isoforms may be a marker for Wilson's disease in neonates.  (+info)

The reactions of copper proteins with nitric oxide. (5/796)

Nitric oxide (NO) can act as a ligand for copper atoms and may also engage in redox chemistry with the metal once bound. Furthermore NO posses an unpaired electron which can couple with the unpaired electron on Cu2+. These properties have been exploited to probe the active sites of copper-containing enzymes and proteins. We review these studies. In addition to the use as a spectroscopic probe for the active site we draw attention to the rapid reactions of NO at the copper sites in Cytochrome c oxidase (CcO) and laccase. These reactions in CcO occur in the ms time range, at low NO concentrations and in the presence of oxygen and may therefore be of physiological relevance to the control of respiration. Finally we speculate on the wider role that NO may play in regulation of an important group of Type 2 copper containing enzymes.  (+info)

Abnormality in urinary protein excretion in Japanese men with impaired glucose tolerance. (6/796)

OBJECTIVE: To examine whether subjects with impaired glucose tolerance (IGT) for more than 2 years have any abnormality in the kidney. RESEARCH DESIGN AND METHODS: We measured urinary excretion rate and clearance of various plasma proteins with different molecular radii and different isoelectric points in 22 Japanese men with IGT (IGT group) and 37 age-matched healthy control subjects (control group). RESULTS: Clearance of ceruloplasmin (molecular radius approximately 45 A; isoelectric point 4.4), IgG4 (molecular radius 55 A; isoelectric point 5.4), and IgG (molecular radius 55 A; isoelectric point 7.4) was significantly higher in the IGT group than in the control group, whereas there were no significant differences in urinary excretion rate of albumin (molecular radius 36 A; isoelectric points 4.8-5.2) and clearance of alpha 2-macroglobulin (molecular radius 88 A; isoelectric point 5.4) between the two groups. CONCLUSIONS: In the present study, we found that clearance of neutral-charged IgG, negatively charged IgG4, and ceruloplasmin with molecular radii of approximately 45-55 A was selectively increased in IGT subjects. This finding does not seem to be explained by impairment of charge and pore-size selectivity in the glomerulus. Therefore, considering the present result together with our recent finding that enhanced glomerular filtration rate (GFR) after acute protein loading in healthy subjects induced a selective increase in clearance of IgG, IgG4, and ceruloplasmin, we suggest that increased intraglomerular hydraulic pressure, although enhanced GFR was not demonstrated, may be at work in these mildly hyperglycemic subjects.  (+info)

Hepatic hyperplasia and cancer in rats: alterations in copper metabolism. (7/796)

We previously demonstrated that rats exposed to the peroxisome proliferator (PP) diethylhexylphthalate (DEHP) had reduced serum ceruloplasmin (CP) oxidase activity, which suggests tissue copper deposition. Copper is highly toxic in excess, and results in cellular damage and hepatocellular carcinomas (HCC). This study addresses changes in expression of copper-related genes and metal accumulation in hyperplastic liver and tumors induced by PP. Male rats were fed diets containing DEHP or clofibrate (CLF) for 3-60 days (hyperplasia) and 4-chloro-6-(2,3 xylidino)-2-pyrimidinyl-thio(N-beta-hydroxyethyl) acetamide for 10 months (HCC). During hyperplasia, an immediate and progressive decrease in serum CP activity was observed (P < 0.05), as were reductions in mRNA levels for both CP and Wilson's disease gene (WD gene, a P-type ATPase) (P < 0.05). Tumor-bearing rats had lower serum CP activity (P < 0.05), and CP and WD gene mRNA levels were reduced in tumors (P < 0.05), and in liver surrounding tumors (SL) (P < 0.05). Metallothionein mRNA showed no consistent changes during hyperplasia. Tumors showed a 2.5-fold induction of metallothionein mRNA (P < 0.05), and a 1.2-fold increase in SL. Temporal increases in liver copper content occurred during hyperplasia, with increases of 2-fold (DEHP) and 3.3-fold (CLF) at 60 days (P < 0.05). Copper content was 2.2-fold higher in tumors (P < 0.05) and 1.7-fold higher in SL; iron did not increase and zinc decreased temporally. Thus, copper accumulation and changes in copper-related gene expression may be contributing factors in liver neoplasia in PP-treated rats. Loss of CP results in decreased free radical scavenger capacity and thus may enhance oxidative damage induced by PPs.  (+info)

Hemolytic activity of copper sulfate as influenced by epinephrine and chelating thiols. (8/796)

AIM: To study the effects of epinephrine, homocysteine, and other complexing agents on the cytotoxicity of copper sulfate. METHODS: In vitro suspensions of human red cells incubated with cupric sulfate were used, and hemolysis was determined by extracellular hemoglobin. RESULTS: The hemolytic activity of CuSO4 (0.3 mmol.L-1) was enhanced by the presence of epinephrine and to a lesser extent by homocysteine, whereas D-penicillamine, succimer, and mercaptodextran reduced the copper-induced hemolysis. The latter 3 chelating thiols also reduced the copper-epinephrine-induced hemolysis. The plasma protein ceruloplasmin reduced markedly the copper-epinephrine-induced hemolysis, even upon concentrations < 20% of that of copper. Chromic chloride, as well, acted anti-hemolytically. CONCLUSION: The latter protectors may interact with the production or activity of toxic oxygen, while classical copper chelators sequester cupric ions from interaction with epinephrine or homocysteine.  (+info)

*Ceruloplasmin

... (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major ... Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin ... Lower-than-normal ceruloplasmin levels may indicate the following: Wilson disease (a rare (UK incidence 2/100,000) copper ... Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) ...

*Wilson's disease

There is no totally reliable test for Wilson's disease, but levels of ceruloplasmin and copper in the blood, as well of the ... Copper accumulates in the liver tissue; ceruloplasmin is still secreted, but in a form that lacks copper (termed ... The liver also releases copper into the bloodstream that is not bound to ceruloplasmin. This free copper precipitates ... non-ceruloplasmin bound) copper has a direct effect on either oxidation of hemoglobin, inhibition of energy-supplying enzymes ...

*Beta-galactoside alpha-2,6-sialyltransferase

Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH (1970). "Physical and chemical studies on ceruloplasmin. 8. ... Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin". J. Biol. Chem. 245 (4): 759-66. PMID 4313609. Paulson JC, ...

*Copper deficiency

Ceruloplasmin also oxidizes iron from its ferrous state to the ferric form that is required for iron binding. Impairment in ... Another iron transporting enzyme is ceruloplasmin. This enzyme is required to mobilize iron from the reticuloendothelial cell ... ceruloplasmin, Cu/Zn superoxide dismutase, and in amine oxidases. These enzyme catalyze reactions for oxidative phosphorylation ...

*Gel electrophoresis of proteins

α2 - haptoglobin, α2-macroglobulin, α2-antiplasmin, ceruloplasmin. The beta (β) band - transferrin, LDL, complement The gamma ( ...

*Multicopper oxidase

... s include: Ceruloplasmin EC 1.16.3.1 (ferroxidase), a 6-domain enzyme found in the serum of mammals and ... Messerschmidt A, Huber R (January 1990). "The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and ...

*GAIT element

Ceruloplasmin is also an acute-phase protein produced by monocytes, and its plasma concentration can double during multiple ... Mazumder B, Sampath P, Fox PL (2005). "Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated ... Mazumder B, Sampath P, Fox PL (2006). "Translational control of ceruloplasmin gene expression: beyond the IRE". Biol Res. 39 (1 ... UTR of the ceruloplasmin (Cp) mRNA. The GAIT element forms a stem-loop secondary structure. The GAIT element is involved in ...

*Hephaestin

While deficiency in hephaestin or ceruloplasmin alone do not seem to cause iron buildup in the retina, studies done on murine ... Human iron metabolism Ceruloplasmin GRCh38: Ensembl release 89: ENSG00000089472 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... While the structure and kinetic activity of ceruloplasmin have been studied extensively, hephaestin has yet to be investigated ... While hephaestin shares 50% amino acid sequence identity with its serum homologue ceruloplasmin, the hephaestin protein ...

*Copper

... which involves the protein ceruloplasmin, carrying the majority of copper in blood. Ceruloplasmin also carries the copper that ... Severe deficiency can be found by testing for low plasma or serum copper levels, low ceruloplasmin, and low red blood cell ... S. S. Percival; Harris, E. D. (1 January 1990). "Copper transport from ceruloplasmin: Characterization of the cellular uptake ... Frieden, E.; Hsieh, H. S. (1976). "Ceruloplasmin: The copper transport protein with essential oxidase activity". Advances in ...

*Metalloprotein

Ceruloplasmin is the major copper-carrying protein in the blood. Ceruloplasmin exhibits oxidase activity, which is associated ...

*Ferroxidase

Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol ... Ceruloplasmin FTH1 - Ferritin heavy chain FTMT - Ferritin, mitochondrial HEPH - Hephaestin Cox JC, Boxer DH (1986). "The role ...

*Paraproteinemia

The α2 region is mostly haptoglobin, α2-macroglobulin, α2-antiplasmin, and ceruloplasmin. The β band consists of transferrin, ...

*Copper in health

The majority of blood copper (or serum copper) is bound to ceruloplasmin. The proportion of ceruloplasmin-bound copper can ... ATP7B directs copper to plasma ceruloplasmin or to biliary excretion in concert with a newly discovered chaperone, Murr1, the ... Most of the copper (70 - 95%) excreted by the liver is incorporated into ceruloplasmin, the main copper carrier in blood. ... Copper is transported to extra-hepatic tissues by ceruloplasmin, albumin and amino acids, or excreted into the bile. By ...

*Aceruloplasminemia

Ceruloplasmin helps move iron from the organs and tissues of the body and prepares it for incorporation into a molecule called ... When ceruloplasmin is unavailable, transport of iron out of the body's tissues is impaired. The resulting iron accumulation ... The CP gene mutation results in the production of ceruloplasmin protein that is unstable or nonfunctional by altering the open ... Diagnosis of this disorder depends on blood tests demonstrating the absence of serum ceruloplasmin, combined with low serum ...

*Florica Topârceanu

"Considerations about the possible function of ceruloplasmin in influenza and parainfluenza virus infection". www. ...

*Thrombin

"Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular ...

*Acute-phase protein

... ceruloplasmin, serum amyloid A and haptoglobin. Others give negative feedback on the inflammatory response, e.g. serpins. Alpha ...

*CLCN4

ClC-4 promotes copper incorporation into ceruloplasmin". Gastroenterology. 126 (4): 1157-66. doi:10.1053/j.gastro.2004.01.015. ...

*Hepatocyte

... ceruloplasmin, transferrin, complement, and glycoproteins. Hepatocytes manufacture their own structural proteins and ...

*Amyloid precursor protein

These iron-transporters can then be activated by known mammalian ferroxidases (i.e. ceruloplasmin or hephaestin). The amyloid-β ... on Alzheimer's is revealed by a mouse study that has found that APP possesses ferroxidase activity similar to ceruloplasmin, ...

*Reference ranges for blood tests

Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper. If ...

*Kayser-Fleischer ring

The combination of neurological symptoms, a low blood ceruloplasmin level and KF rings is diagnostic of Wilson's disease. Other ...

*Tic

If a family history of liver disease is present, serum copper and ceruloplasmin levels can rule out Wilson's disease. ...

*Discoidin domain

... a blood coagulation factor homologous to factor VIII and ceruloplasmin". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6800-6804. doi: ...

*SLC33A1

... and low serum copper and ceruloplasmin". American Journal of Human Genetics. 90 (1): 61-8. doi:10.1016/j.ajhg.2011.11.030. PMC ...
Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat mammary gland tissue from pregnant and lactating animals. Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other extrahepatic tissues. Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus. In virgin female mammary gland the content of ceruloplasmin mRNA was 20% of that in hepatic tissue from these animals and approx. 2-3-fold greater than that found in mammary gland tissue of pregnant or lactating animals. Development studies revealed ceruloplasmin gene expression in male and female mammary gland by only 2 weeks of age, prior to the onset of puberty. Biosynthetic studies indicated that the ceruloplasmin mRNA in ...
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. The rest is accounted for by macroglobulins. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. The molecular weight of human ceruloplasmin is reported to be 151kDa. A cis-regulatory element called the ...
Structure of Ceruloplasmin. CP is involved in oxidative stress and in the safe handling of oxygen in some metabolic pathways of vertebrates and has been shown to be associated with reproduction. Serum levels of ceruloplasmin have been found to increase during normal pregnancy in some species and it is thought that this increase during gestation protects against oxidative stress associated with pregnancy. In dogs, the increase in serum ceruloplasmin has been coupled to the time of embryonic endometrial implantation and placentation. In 2011, Erin Willis from the Memphis Zoo published evidence that Cp activity could be correlated to pregnancy status in giant pandas1. The activity of urinary ceruloplasmin was higher during the pregnant luteal phase compared to the pseudopregnant luteal phase. In all term pregnancies examined, levels of active ceruloplasmin were elevated the first week of pregnancy and remained elevated until 20-24 days prior to parturition.. Decreased concentrations occur during ...
Injection of a 2.0 mg Cd ²⁺ /kg B.W. (I.P. as CdC1 ₂ in .05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine oxidase activity within one hour of injection. Maximal decrease (40%) occurred within six to eight hours, with levels rising slowly over the duration of the experiment (28.5 hours postinjection). Cadmium-109 (36 pCi carrier free ¹⁰⁹ CdC1 ₂ in .05 M HC1, .15 M NaC1) was injected (I.P.) into rats and plasma obtained five hours later. Purification of the ceruloplasmin using DEAE and Sephadex G-200 chromatography revealed significant cadmium-109 in the ceruloplasmin fraction. In vitro binding was not observed. Attempts were made to purify ceruloplasmin utilizing, DEAE, hydroxylapatite and Sephadex G-200 chromatography coupled with ethanol-chloroform precipitation. The product obtained was spectrophotometrically pure and deemed electrophoretically homogeneous, however antibody produced in rabbits to this ...
TY - JOUR. T1 - Copper-related blood indexes in kidney dialysis patients. AU - Emenaker, Nancy J.. AU - DiSilvestro, Robert A.. AU - Nahman, N. Stanley. AU - Percival, Susan. PY - 1996/11. Y1 - 1996/11. N2 - Previous work has suggested that kidney hemodialysis patients could be at risk for either moderate copper deficiency or copper toxicity. The present study examined copper-related blood indexes in subjects undergoing hemodialysis treatments with membranes that are not copper-based, in subjects undergoing chronic ambulatory peritoneal dialysis (CAPD), and in control subjects. Both dialysis groups had low plasma copper and ceruloplasmin activities. This occurred despite high plasma interleukin 6 concentrations, a situation that usually elevates plasma ceruloplasmin and copper values. CAPD and hemodialysis subjects had low ratios of ceruloplasmin activity to immunoreactive protein, and low ratios of plasma copper to ceruloplasmin protein. Both are signs of copper deficiency. In contrast, ...
1. It has been suggested that low levels of serum caeruloplasmin in Wilsons disease result from the failure to switch from a fetal to an adult mode of caeruloplasmin gene expression. To investigate postnatal expression of the caeruloplasmin gene, steady-state levels of caeruloplasmin messenger RNA in adult and neonatal rat liver were measured.. 2. Copper parameters observed in neonatal rats were similar to those seen in Wilsons disease: hepatic copper concentration was significantly elevated (neonatal 164 ± 35 μg/g, adults 50 ± 8 μg/g, P , .001) and serum copper and caeruloplasmin levels were low (neonatal 0.5 ± 0.1 μg/ml, adults 1.3 ± 0.2 μg/ml, P , .001; neonatal 0.20 ± 0.04 arbitrary units, adults 0.69 ± 0.16 arbitrary units, P , .001), respectively.. 3. Caeruloplasmin messenger RNA levels were analysed by Northern and dot blotting using a 12P-labelled caeruloplasmin complementary DNA probe. A caeruloplasmin messenger RNA of approximately 4.4 kilobases was detected in both adult ...
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The LEGENDplex™ Human Acute Phase Panel 1 Mix and Match Beads are individual capture beads for 8 targets including α2-macroglobulin, α1-AGP, Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and Matc
Infobox_gene}} Ceruloplasmin (or caeruloplasmin) is a [[ferroxidase]] [[enzyme]] that in humans is encoded by the CP [[gene]].,ref name="pmid6582496">{{cite journal , vauthors = Takahashi N, Ortel TL, Putnam FW , title = Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule , journal = Proceedings of the National Academy of Sciences of the United States of America , volume = 81 , issue = 2 , pages = 390-4 , date = Jan 1984 , pmid = 6582496 , pmc = 344682 , doi = 10.1073/pnas.81.2.390 }},/ref>,ref name="pmid2873574">{{cite journal , vauthors = Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT , title = Complete cDNA sequence of human preceruloplasmin , journal = Proceedings of the National Academy of Sciences of the United States of America , volume = 83 , issue = 14 , pages = 5086-90 , date = Jul 1986 , pmid = 2873574 , pmc = 323895 , doi = 10.1073/pnas.83.14.5086 }},/ref>,ref name="pmid3474786">{{cite journal , vauthors = Royle ...
ST.LOUIS- The discovery of a gene associated with a rare form of Parkinsons disease provides researchers with a long sought piece to the puzzling pathogenesis of this disease.. A team of researchers at Washington University School of Medicine in St. Louis have characterized a rare disease, aceruloplasminemia, that causes a rare form of Parkinsons. Aceruloplasminemia is caused by a mutation in the ceruloplasmin gene, which is involved in iron transport.. Patients with this gene mutation do not make ceruloplasmin, a protein that removes iron from cells. The iron then accumulates in cells in the brains basal ganglia region and causes neurological problems. These include the tremors and gait abnormalities associated with Parkinsons disease, according to Jonathan D. Gitlin, M.D., associate professor of pediatrics, Washington University School of Medicine.. Neurologists have long hypothesized that Parkinsons disease results from a combination of genetic and environmental factors. The current ...
Methods and Results-Cp was measured at ARIC visit 4 (1996-1998). We studied 9240 individuals without HF or CVD at ARIC visit 4 and followed them for a mean of 10.5 years. Genome-wide association study was performed to identify genetic determinants of Cp levels and evaluate their association with incident HF in ARIC participants. Cp levels (mean±SD) were higher in women versus men (335±79 versus 258±44 mg/L; P,0.0001), women on versus not on hormone-replacement therapy (398±89 versus 291±60 mg/L; P,0.0001), and African Americans versus whites (299±63 versus 293±74 mg/L; P=0.0005). After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). A locus on the ceruloplasmin gene on chromosome 3 was significantly ...
Background and Purpose: Pre-eclampsia is a pregnancy disorder which increases maternal and pre-natal morbidity and mortality. The incidence is about 5% and is influenced by pariety, genetic background, and environmental factors. At present, the sole treatment is termination. It is suitable to use antioxidants for pre-eclampsia prevention. The aim of this ...
Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free radical scavenger. The structural organization of Cp causes its sensitivity to proteolysis and ROS (reactive oxygen species), which can alter some of the important Cp functions. Eluc
Ceruloplasmin (též ceruloplazmin) je bílkovinná sloučenina s vlastnostmi enzymu, která je v organizmu důležitá pro transport molekul mědi a pro metabolizmus železa (přeměna iontu Fe2+ na Fe3+). Snížená koncentrace ceruloplasminu je velmi často přítomna u jedinců s Wilsonovou nemocí, není však příčinou jejího vzniku ...
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Description: The Serum Copper test is, along with serum ceruloplasmin, is used to test for Wilson disease and more frequently used to monitor nutrition, especially when copper deficiency is indicated ...
Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. The Dunaief lab has found that AMD retinas have iron overload, which can cause oxidative stress. Increased understanding of retinal iron homeostasis may lead to treatments for AMD. To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. A mouse line deficient in the iron transporting ferroxidases ceruloplasmin and hephaestin develops age-dependent retinal iron overload and retinal degeneration with features of AMD (Hahn et al., PNAS, 2004). Recent research in the lab indicates that inflammation promotes cellular iron overload in a vicious cycle leading to cell death. Our current focus is on the mechanisms of retinal iron homeostasis and development of therapeutics to ...
Screening tests Serum glucose, electrolytes, calcium/phosphorus, uric acid, lactate and pyruvate, liver, renal and thyroid function tests, blood gasses Prolactin levels (10 to 20 min after suspected seizure, diagnosis seizure vs. psychogenic nonepileptic seizure) Serum CK ANA, ENA, ANCA, RF, complement, ACE, anti-thyroglobulin and anti-thyroperoxidase antibodies (Hashimoto disease), autoantibody panel (thyroid antimicrosomal, antiparietal), immunoglobulins Serum ceruloplasmin…
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Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ; Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.; J Nutr, 2010 PubMed Europe PMC ...
An Interview with William J. Walsh, PhD This is the sixth article in a series of seven articles.. View Part 1, Part 2, Part 3, Part 4 and Part 5.. JH: What kinds of testing do you recommend for patients?. WW: If patients had every blood and urine test that would provide valuable information, they probably wouldnt have any money left - or any blood - so we have to prioritize. Because six or seven factors are dominant in most cases, we start off with a panel of tests that is relatively inexpensive, maybe only $300 or $400. We have to do additional testing in only about ten percent of the cases. We look for markers of oxidative stress and at the important metals, espe-cially zinc and copper, that impact neurotransmitters. We measure the protein called ceruloplasmin because looking at serum copper and ceruloplasmin jointly reveals a lot about free radicals and oxidative stress. We need to have a marker for methylation, and what we have been using is whole blood histamine. Its imperfect, and ...
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1 ...
accounting acidic additional aggravate appears applied assoc atrophy beneficial bottom cellular cognitive college contributed control controls correlated correlation correlations cortex dependent derived determine disease downloaded drive early elderly elucidate enhance explaining export expressed fluid fusiform hand healthy hierarchical homeostasis impairment indicated inflammation institute interact involved iron king kingdom latter marker matched measures metabolism metal mild model negatively operates park pathogenesis pathology positively progression protein proteins psychiatry psychology reactive regression regulatory relationship respectively restore seems significantly stage store subjects suggesting supports synergy therapies tracking true variable variation ventricles volume volumes whereas ...
Membrane Protein Involved In Zinc Ion Homeostasis; Member Of The Four-protein IZH Family, Expression Induced By Zinc Deficiency; Deletion Reduces Sensitivity To Elevated Zinc And Shortens Lag Phase, Overexpression Reduces Zap1p Activity
I had my first FET with a normal embryo. My RE said it had an 85% chance of implanting, but it didnt. Im looking for reasons this might have happene
I know I am getting in early but figure may as well as I cant be the only one waiting til October to start our FET. I didnt think Id be back here after we got our BFP in March after our first successful round but unfortunately our DD - page 55
Aceruloplasminemia is a rare autosomal recessive disorder in which iron gradually accumulates in the retina, basal ganglia, and other organs. Iron accumulation in the brain results in neurological problems that generally appear in adulthood and worsen over time. Aceruloplasminemia has been seen worldwide, but its overall prevalence is unknown. Studies in Japan have estimated that approximately 1 in 2 million adults in this population are affected. Aceruloplasminemia belongs to the group of genetic disorders called neurodegeneration with brain iron accumulation (NBIA). Patients with aceruloplasminemia develop a variety of movement problems. They may experience dystonia of the head and neck, resulting in repetitive movements and contortions. Other involuntary movements may also occur, such as tremors, chorea, blepharospasms, and grimacing. Affected individuals may also experience ataxia, the lack of coordination of muscle movements. Some develop psychiatric problems and midlife dementia. The type ...
Periodontitis, is an infectious ailment of multifactorial origin, that brings about destruction of bone and surrounding tissues. There are various oral pathogens that may be responsible for the destruction. The host encounters these microbial invasions and their products by the production and release of inflammatory mediators from the cells within the body. Glutathione-S-transferase (GST) are a group of enzymes that utilize glutathione in conditions resulting in oxidative stress. These enzymes play a key role in the detoxifycation of such substance. It aids in preventing damage to important cellular components caused by release of free reactive oxygen species. Ceruloplasmin is a ferroxidase enzyme. It plays a role as an anti-inflammatory agent, by its ability to scavenge free radicals within the body. The present study was targeted at evaluating the levels of Glutathione-S-Transferase (GST) and Ceruloplasmin as diagnostic markers for patients with chronic periodontitis in gingival crevicular fluid (GCF)
Looking for Copper oxidase? Find out information about Copper oxidase. The copper-binding serum protein in human blood. a copper-containing protein of the α2-globulin fraction of blood plasma. It was first discovered and... Explanation of Copper oxidase
In this report, we present novel evidence linking FLP to high-affinity Fe transport and propose that FLP is a ferroxidase, functioning in the reoxidation of Fe2+ before its uptake into the cell. Initial evidence in support of this hypothesis comes from the deduced FLP amino acid sequence. FLP contains two multicopper oxidase I and one multicopper oxidase signature II motifs. In addition, the amino acid sequence of FLP shows the highest homology to multicopper oxidases in mammals (HEPH and ceruloplasmin) and yeast (FET3). These proteins are ferroxidases that are themselves involved in high-affinity Fe assimilation (Stearman et al., 1996;Askwith and Kaplan, 1998; Mukhopadhyay et al., 1998; Attieh et al., 1999; Vulpe et al., 1999). The involvement of FLP in Fe homeostasis is evident from the regulation of its synthesis. Both the transcription of the FLP gene and synthesis of FLP are greatly increased in Fe-deficient cells and reversed after resupply of Fe. Although we have not demonstrated the ...
Ferritins are ubiquitous and can be found in practically all organisms that utilize Fe. They are composed of 24 subunits forming a hollow sphere with an inner cavity of ~80 A in diameter. The main function of ferritin is to oxidize the cytotoxic Fe(2+) ions and store the oxidized Fe in the inner cavity. It has been established that the initial step of rapid oxidation of Fe(2+) (ferroxidation) by H-type ferritins, found in vertebrates, occurs at a diiron binding center, termed the ferroxidase center. In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C). In an effort to obtain further evidence supporting the presence of a trinuclear Fe binding center in bacterial ferritins and to gain information on the states of the iron bound to the trinuclear ...
CuD subjects In order to be enrolled into the CuD Arm, subjects who have had RYGB surgery will be recruited and screened for eligibility (inclusion and exclusion criteria below). Subjects whose plasma copper concentrations are in the deficient range (less than 80 μg/dL for women and less than 70 µg/dL for men, and/or ceruloplasmin activity below 62 units/L-1) following 4 weeks of supplementation with the RDA for copper will be eligible. Such supplementation is the routine standard of care with all patients undergoing RYGB surgery. This process aims to exclude patients who were only marginally copper deficient and not in need of sustained copper therapy. Subjects will be notified about their copper status by a study physician. They will be contacted by the study team, and their willingness to participate in the study will be determined.. Inclusion criteria: 1) Patient has a history of RYGB weight loss surgery; 2) subject has a plasma copper level which is less than 80 μg/dL for women andl less ...
References 1. Cauza E, Maier-Dobersberger T, Polli C, Kaserer K, Kramer L, Ferenci P. Screening for Wilsons disease in patients with liver diseases by serum ceruloplasmin. Journal of hepatology. 1997;27:358-62. 2. Medici V, Rossaro L, Sturniolo GC. Wilson disease--a practical approach to diagnosis, treatment and follow-up. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2007;39:601-9. 3. Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology (Baltimore, Md). 2008;47:2089-111. 4. Stremmel W, Meyerrose KW, Niederau C, Hefter H, Kreuzpaintner G, Strohmeyer G. Wilson disease: clinical presentation, treatment, and survival. Annals of internal medicine. 1991;115:720-6. 5. Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annual review of nutrition. 2002;22:439-58. 6. Scott J, Gollan JL, Samourian S, Sherlock S. Wilsons disease, presenting as chronic active ...
The relation between elevated ISPs and an increased incidence of acute coronary events is now well established. Whether the fatality of the events is related to the previous exposure to a low-grade inflammation has been unclear. In the entire cohort, the relative risks were higher for CHD deaths than for nonfatal MI. Among men who subsequently had acute coronary events, the number of elevated ISPs at baseline showed significant associations with the proportions of fatal outcomes (first day or within 28 days). The individual ISPs showed nonsignificant differences between CHD deaths and nonfatal MI. However, in accordance with many previous studies, the prognostic information increased substantially if all 5 ISPs were used.2,11,12,15 The results show that men who have been exposed to a low-grade inflammation many years earlier have higher fatality in future acute coronary events, with a higher proportion of CHD deaths and less nonfatal MI. If this finding can be replicated in other ...
Wilsons Disease Treatment of Alternative Wilsons Disease Alternative Neuro Acupuncture Treatment and Wilsons Disease Herbal Herbs Alternative Medicine Treatment on Wilsons Disease Treatment Medical Center Wilsons Disease Remedies
Copper in blood and liver can be divided into several fractions. Copper in blood is about evenly divided between erythrocytes and plasma. Normal concentrations for most species range between one and two parts per million. Plasma copper is mainly a copper protein, ceruloplasmin and a loosely bound form, reacting directly with Na diethyldithiocarbamate (DR Cu). In livers of normal rats (ca. 18 ppm Cu) the distribution is: debris, 12.8%; mitochondria, 13.5%; microsomes, 17.9%; and soluble fraction, 54.8%. On the other hand, in cattle with higher liver copper levels (ca. 69.5 ppm) the distribution is: debris, 22.2%; mitochondria, 12.3%; microsomes, 14.6%; and soluble fraction, 50.9%. The distributions are influenced by dietary copper in rats fed rations containing from 1 ppm to 200 ppm Cu. Erythrocyte and DR Cu appeared to be directly related to the copper intake, with values ranging from 0.95 to 2.04 μg/ml and 0.19 to 1.52 μg respectively. Ceruloplasmin values were depressed in the low ration ...
... To say Copper is an essential trace mineral barely does justice when one considers the wide range of vital human bodily functions dependent upon this mighty mineral. To begin with, copper is a major component of hemoglobin, the protein resposible for oxygen transport in blood cells. Copper, along with vitimin C, forms elastin, a protein required to keep skin, blood vessels, and lungs supple and elastic. As an antioxidant, copper plays a strong dual role. First as a central component of both the superoxide dismutase molecule, which protects us from cellular free-radical damage. Secondly, copper helps form the protein ceruloplasmin, which protects us against free-radical damage caused by iron. Copper is also required by the central nervous system as a component in the production of noradrenaline, the brains version of adrenaline and the neurotransmitter that keeps us alert. Copper is also involved in the production of prostaglandins, hormonelike chemicals that regulate ...
Further Observations generic cialis available on the Diseases which affect the Synovial Membranes of Joints. Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. Mechanism for hormone-induced alterations in serum ceruloplasmin. Hence, global gene-expression profiling on inguinal lymph nodes was performed 10 days after the induction of pristane-induced arthritis (PIA) and phytol administration.. According to the method used, no generic cialis available significant beneficial effect could be demonstrated in either experimental model. The dichotomous response pattern and positivity offset differed between words and pictures in patients with alcohol dependence. In closed glass containers exposed to about I Mrad of gamma radiation, ozone concentrations up to 18 parts per million (by volume) were recorded. Effect of ...
DESIGN: The test was performed on juvenile fish, which was exposed to Spartakus (concentrations of prochloraz: 0.05; 0.15 and 0.38 mg.L-1) for 28 days. Haematological indices were assessed using unified methods of haematological examination in fish. Plasma biochemical indices were determined by biochemical analyzer. Concentration of total cytochrome P450 (CYP), glutathione (GSH) content and glutathione-S-transferase (GST) activity were determined spectrophotometrically in hepatopancreas. Activity of liver ethoxyresorufin-O-deethylase (EROD) activity was measured spectrofluorimetrically. Ferric reducing ability of plasma (FRAP) and ceruloplasmin activity were assessed spectrophotometrically. Histological changes in samples of hepatopancreas, skin, gills, spleen, head kidney and caudal kidney were examined by light microscopy ...
In episode 33, we continue the series on assessing and managing nutritional status. This time we talk about copper. Copper deficiency can cause anemia that is very difficult to tell apart from iron-deficiency anemia, osteoporosis, histamine intolerance, high cholesterol, and a variety of mental effects resulting from neurotransmitter imbalances. Serum copper and ceruloplasmin are excellent tools for assessing nutritional status, but are confounded by inflammation, birth control, menopausal status, and hormone replacement therapy, making it necessary to look at the diet, lifestyle, digestive problems, and other factors that make copper deficiency plausible.  I discuss how to protect yourself from the small risk of copper in your drinking water, and why I think many claims about excess copper outside the context of frank toxicity are misleading. Everything converges on the practical questions of what to do in these situations. You can find the show notes to this episode at chrismasterjohnphd.com/33.
Effect of copper deficiency on prenatal development and pregnancy outcome.: Copper deficiency during embryonic and fetal development can result in numerous gros
Copper is an essential micronutrient for most organisms, especially in respiring eukaryotes, due to its being a cofactor in electron transfer proteins and in enzymes that catalyze redox reactions or oxygen chemistry, such as cytochrome oxidase, ferroxidases, and Cu/Zn superoxide dismutases. The availability of copper in the environment or in the nutrient source may vary widely, however, and copper deficiency is a challenge that many organisms encounter, a challenge they have met through the evolution of sophisticated adaptive mechanisms. At the same time, free copper ions have the potential to participate in Fenton chemistry resulting in the production of reactive oxygen species. Copper assimilation must therefore be tightly regulated so as to meet but not exceed cellular requirements (reviewed in Eide, 1998; Puig and Thiele, 2002; Winge, 2002; Merchant et al., 2006; Pilon et al., 2006),. Genetic and biochemical studies in a number of model organisms have established the existence in eukaryotes ...
Copper is an essential trace element. It is required for ferro-oxidase activity which is an essential stage for incorporation of iron into haem. Copper is absorbed in the intestines and then transported to the liver, where it is stored or used in the production of a variety of enzymes. Caeruloplasmin is a copper-containing enzyme that plays a role in the bodys iron metabolism. In the blood, 95 % is bound to caeruloplasmin and 5 % is free. It is used in conjunction with serum copper assay to help diagnose Wilsons disease and evaluate copper metabolism.. ...
Normally food copper is metabolized by the liver and channeled into safe pathways such as being incorporated in to ceruloplasmin. [...] When we administer inorganic copper orally labeled with 64Cu, we see a fraction of the label appear in the blood in 1-2 hours, too soon to be processed by the liver. [...] We believe this fraction of 64Cu-labeled inorganic copper is bypassing the liver, is therefore not incorporated safely into ceruloplasmin, contributes directly to the nonceruloplasmin free copper pool, and represents what is happening to at least a portion of the inorganic copper ingested in drinking water or copper supplements."[32] ...
We found an age-related increase of iron in the white matter of controls as well as in patients with short disease duration. In chronic MS, however, there was a significant decrease of iron in the normal-appearing white matter (NAWM) corresponding with disease duration, when corrected for age. This decrease of iron in oligodendrocytes and myelin was associated with an upregulation of iron-exporting ferroxidases. In active MS lesions, iron was apparently released from dying oligodendrocytes, resulting in extracellular accumulation of iron and uptake into microglia and macrophages. Iron-containing microglia showed signs of cell degeneration. At lesion edges and within centers of lesions, iron accumulated in astrocytes and axons ...
Wilsons disease (-) ceruloplasmin does not rule out Keyser-Fleischer rings absent in 50% AST & ALT |1500 Normal or low alk phos for age (cofactor Zn displaced by Cu) AST:ALT |2.2 AlkPhos : TotBili |4
Patients with moderate to high risk primary breast cancer (Stage II with more than 4 lymph nodes involved with cancer) III or Stage IV (without evidence
Our physicians collaborate closely to diagnose and treat Wilsons disease. Treatment depends on the organs involved and overall health of the patient.
Serum levels rise for other proteins, cialis 5mg wirkungseintritt such as ceruloplasmin, complement proteins, haptoglobin, fibrinogen, and C-reactive
Topley & Wilsons microbiology and microbial infections , Topley & Wilsons microbiology and microbial infections , کتابخانه دیجیتال دانشگاه علوم پزشکی تهران
Just thinking out loud... Question: How valuable is it knowing SHBG numbers mid-cycle? seems it would be more helpful to know between cycles, right?
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Page contains details about few-layer SnS2 FET . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
(Quote) last year when I had my FET I was supremely confident it would work (tw it did, but I mced) PLUS I had been testing and poasing and knew by then I was...
Wilson disease is a rare autosomal recessive inherited disorder of copper metabolism. The condition is characterized by excessive deposition of copper in the liver, brain, and other tissues.
Aceruloplasminemia is a disorder in which iron gradually accumulates in the brain and other organs. Iron accumulation in the brain results in neurological problems that generally appear in adulthood and worsen over time.. People with aceruloplasminemia develop a variety of movement problems. They may experience involuntary muscle contractions (dystonia) of the head and neck, resulting in repetitive movements and contortions. Other involuntary movements may also occur, such as rhythmic shaking (tremors), jerking movements (chorea), eyelid twitching (blepharospasm), and grimacing. Affected individuals may also have difficulty with coordination (ataxia). Some develop psychiatric problems and a decline of intellectual function (dementia) in their forties or fifties.. In addition to neurological problems, affected individuals may have diabetes mellitus caused by iron damage to cells in the pancreas that make insulin, a hormone that helps control blood sugar levels. Iron accumulation in the pancreas ...
Wilsons disease (WD) is a rare autosomal recessive disorder of copper metabolism. Data regarding WD is not available from Pakistan. A cross-sectional study was conducted at The Aga Khan University Hospital, Karachi, and all patients admitted with primary and secondary diagnosis of Wilsons disease were added. A total of 47 patients were seen; 68% (n = 32) were male. The mean age was 26.6 ± 9.97 years. Most of the patients presented with hepatic, (n = 22, 46.8%), neurological, (n = 17, 36.2%) and psychiatric (n = 8, 17%) symptoms. Mean ceruloplasmin level was 0.17 ± 0.13 g/dl; it was | 0.25 g/dl in 39 (86.6%) patients. Serum copper (Cu) was reduced in 32 (68.1%) patients and 24-hr-urinary Cu was raised in 22 (47.6%) patients. Slit lamp examination for Kayser-Fleischer (KF) rings was done on 15 (31.9%) patients and 9 (60%) of them had KF rings. Mean serum aspartate transaminase (AST) / alanine transaminases (ALT) ratio was 1.92 and median alkaline phosphatase / total bilirubin ratio was 79.30 (IQR 35
TY - JOUR. T1 - Low levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide. AU - Chao, J. C J. AU - Medeiros, D. M.. AU - Davidson, J.. AU - Shiry, L.. PY - 1994. Y1 - 1994. N2 - This study determined if reported decreases in the δ subunit of ATP synthase and nuclear-encoded cytochrome c oxidase subunits in hearts of copper-deficient rats were secondary to the heart disease pathology or due to lack of the trace element. Male weanling Long-Evans rats were randomly divided into six groups: rats fed a copper-adequate or copper-deficient diet (with free access) with or without 5% dimethyl sulfoxide (DMSO) in the drinking water and rats pair-fed the copper-adequate or copper-deficient diet without DMSO treatment. After 4 wk, rats in the groups fed the copper- deficient diet had lower liver superoxide dismutase and heart cytochrome c oxidase activities compared with groups fed the copper-adequate ...
The measurement of serum caeruloplasmin and copper concentrations should be available locally via most hospital laboratories. The reference range for serum caeruloplasmin is between 200 and 600 mg/litre (there may be some local variation depending on the method used). Caeruloplasmin should be measured immunochemically by turbidimetry or nephelometery, although radial diffusion is also acceptable. The method should be capable of accurately measuring caeruloplasmin at a concentration as low as 100 mg/litre. The reference range for serum copper is 10-22 μmol/litre. It should be measured using a flame atomic absorption spectrometer or an inductively coupled plasma optical emission spectrometer.. For both copper and caeruloplasmin measurements, a 5 ml plain tube of blood is appropriate; for paediatric samples enquire at the local laboratory for minimum volumes.. The combination of serum caeruloplasmin below 200 mg/litre with KF rings is diagnostic for the disease.4 Other medical conditions can cause ...
CUCRU : The biliary system is the major pathway of copper excretion. Biliary excretion of copper requires an adenosine triphosphate (ATP)-dependent transporter protein. Mutations in the gene for the transporter protein cause hepatolenticular degeneration (Wilson disease). Ceruloplasmin, the primary copper-carrying protein in the blood, is also reduced in Wilson disease. Urine copper excretion is increased in Wilson disease due to a decreased serum binding of copper to ceruloplasmin, or due to allelic variances in cellular metal ion transporters.   Hypercupriuria is also found in hemochromatosis, biliary cirrhosis, thyrotoxicosis, various infections, and a variety of other acute, chronic, and malignant diseases (including leukemia). Urine copper concentrations are also elevated in patients taking contraceptives or estrogens and during pregnancy.   Low urine copper levels are seen in malnutrition, hypoproteinemias, malabsorption, and nephrotic syndrome. Increased zinc consumption interferes
TY - JOUR. T1 - Heterotopic liver transplantation for fulminant Wilsons disease. AU - Stampfl, David A.. AU - Muñoz, Santiago J.. AU - Moritz, Michael J.. AU - Rubin, Raphael. AU - Armenti, Vincent T.. AU - Jarrell, Bruce E.. AU - Maddrey, Willis C.. PY - 1990. Y1 - 1990. N2 - Wilsons disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilsons disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated with heterotopic liver transplantation. However, use of heterotopic liver transplantation for fulminant hepatocellular failure has not been successful. This case study involves a patient in whom a heterotopic liver transplant was successfully used for treatment of Wilsons disease presenting with fulminant hepatocellular failure.. AB - Wilsons disease may present with severe acute hepatocellular failure. The ...
Looking for online definition of copper deficiency in the Medical Dictionary? copper deficiency explanation free. What is copper deficiency? Meaning of copper deficiency medical term. What does copper deficiency mean?
article{adc8b173-8290-4fe1-95e9-3dbfeae73d48, abstract = {Background- The extent to which differences in cardiovascular risk between smokers with similar daily tobacco consumption may be related to plasma levels of inflammation-sensitive proteins (ISP) and whether these proteins are associated with levels of carboxyhemoglobin (COHb%) have not been clarified.,br/,,br, ,br/,,br, Methods and Results- In a population-based cohort of 1489 never smokers, 1685 former smokers, and 2901 current smokers, aged 28 to 61 years, plasma levels of orosomucoid ({alpha}1-acid glycoprotein), {alpha}1-antitrypsin, haptoglobin, fibrinogen, and ceruloplasmin were measured. COHb% levels were available for 2098 of them. Incidence of myocardial infarction, stroke, and death were monitored over 18.7±4.7 years. The proportion with high ISP levels (ie, >=2 ISP in the top quartile) increased progressively with daily tobacco consumption (P<0.01) and COHb% (P<0.01). In all smoking categories, the incidence of ...
Vulpe C.D., Kuo Y.M., Murphy T.L., Cowley L., Askwith C., Libina N., Gitschier J., Anderson G.J.. Iron is essential for many cellular functions; consequently, disturbances of iron homeostasis, leading to either iron deficiency or iron overload, can have significant clinical consequences. Despite the clinical prevalence of these disorders, the mechanism by which dietary iron is absorbed into the body is poorly understood. We have identified a key component in intestinal iron transport by study of the sex-linked anaemia (sla) mouse, which has a block in intestinal iron transport. Mice carrying the sla mutation develop moderate to severe microcytic hypochromic anaemia. Although these mice take up iron from the intestinal lumen into mature epithelial cells normally, the subsequent exit of iron into the circulation is diminished. As a result, iron accumulates in enterocytes and is lost during turnover of the intestinal epithelium. Biochemical studies have failed to identify the underlying difference ...
Download Free Full-Text of an article CORRELATION BETWEEN SERUM AND ERYTHROCYTE SUPEROXIDE DISMUTASE WITH SERUM HOMOCYSTEINE IN MYOCARDIAL INFARCTION
A salient feature of copper deficiency is the development of anemia first documented experimentally in rats in 1928 (Hart et al. 1928). CuD rats develop hypoferremia as displayed in several rat models in the current studies. Iron deficiency also results in hypoferremia and anemia, and it is commonly suggested that anemia of copper deficiency is caused by a secondary (induced) iron deficiency (Chen et al. 2006; Reeves et al. 2005). However, there are exceptions that question this logic. CuD mice often have no changes in plasma iron but are profoundly anemic (Pyatskowit and Prohaska 2008a). Injection of anemic postweanling CuD rats and mice with iron does not reverse anemia (Prohaska et al. 1985; Reeves and DeMars 2006; Williams et al. 1983). Further, Cp −/− mice and humans with aceruloplasminemia exhibit hypoferremia but only mild anemia, as reviewed elsewhere (Prohaska 2011). However, iron delivery to bone marrow may still be partially responsible for anemia.. Why does hypoferremia develop ...
The NBIA Disorders Association is your number 1 resource for education, advocacy, research news and family support for Neurodegeneration with Brain Iron Accumulation (NBIA) disorders.
The long term goal of the research conducted in my lab is to learn about the general principles that organisms use to acquire and metabolize the essential nutrient iron. Since in eukaryotes, iron metabolism depends on the activity of copper-containing enzymes called ferroxidases, we examine the trafficking copper in cells as well. The first challenge for a cell is to scavenge these two metals from the environment. This is true for a yeast cell in culture, or for an epithelial cell in your intestine. The second challenge is to efficiently and correctly partition these metals in the cell for subsequent utilization and storage. Ultimately the cell or organism will have to regulate the accumulation of these metals and to ensure that they are not allowed to roam "free" since both are toxic ...
The following investigations were performed and were all normal: urine organic acids, serum amino acids, tandem mass spectrometry, serum copper, serum CP, 24-hour urinary copper level, complete blood count, serum iron, and ferritin level. Nerve conduction study and ophthalmology assessment were also normal. Magnetic resonance imaging (MRI) of the brain showed iron deposition on the basal ganglia (T2 hypointensity in globus pallidus bilaterally) [Figure 2].. The ATP13A2, C19orf12, CP, FA2H, FTL, PANK2, and PLA2G6 genes were analyzed from blood sample using the polymerase chain reaction (PCR) and next-generation sequencing of both strands of the entire coding region and the highly conserved exon-intron splice junctions. Next-generation sequencing was done via an amplicon-based approach using the Roche 454 genome sequencer. No pathogenic mutation was detected in any of the genes; however, after few repetitions of C19orf12 exon 2 sequence analysis, the results were not obtainable, indicating a ...
Room temperature spectroscopic ellipsometry measurement of Cu0.86In1.09Se2.05 reveals that shallow defect states are found in the sub-band-gap region. The energies of these defect levels are in quantitative agreement with those calculated and measured by photoluminescence, electrical conductivity, optical absorption, and deep level transient spectroscopy at low temperatures. The results can be explained in terms of the defect physics of this material and suggest that the defect levels are due to Cu deficiency. This work opens up the possibility of measuring defect levels of off-stoichiometric or heavily doped semiconductors by spectroscopic ellipsometry at room temperature ...
http://www.ninds.nih.gov/health_and_medical /disorders/wilsons_doc.htm http://www.medgen.med.ualberta.ca/database.html top References Sass-Kortsak A. Wilsons disease. A treatable liver disease in children. Pediatr Clin North Am. 1975;22:963-984. Scheinberg IH, Sternlieb I. Wilsons disease. Philadelphia: WB Saunders; 1984. Walshe JM. Wilsons disease presenting with features of hepatic dysfunction: a clinical analysis of eighty-seven patients. Q J Med. 1989;70:253-263. Danks DM. Disorders of copper transport. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. New York: McGraw-Hill; 1995: 4125-4158. Roberts EA, Cox DW. Wilson disease. Baillieres Clin Gastroenterol. 1998;12:237-256. Sanchez-Albisua I, Garde T, Hierro L, Camarena C, Frauca E, de la Vega A, et al. A high index of suspicion: the key to an early diagnosis of Wilsons disease in childhood. J Pediatr Gastroenterol Nutr. 1999;28:186-190. Wilson DC, Phillips MJ, Cox DW, Roberts EA. Severe hepatic ...
Wilsons disease is an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease.
Wilsons disease has genetic heterogeneity with variations in clinical symptoms among families as well as races and countries. Chinese females had an early onset of symptoms (mean, 11.8 years) and death (mean, 13.9 years), whereas Chinese had later onset (mean, 20.9 years) and age at death (mean, 23.2 years). British patients showed a similar trend, with females having earlier onset of symptoms (mean, 14.9 years) than males (mean, 16.8 years). Males in predominantly female-affected families usually, had early onset, whereas females in predominantly male-affected families had late onset. Twenty-five of 30 patients with onset of symptoms at age 20 years ...
Learn more about Wilsons Disease symptoms, diagnosis, and treatments from experts at Boston Childrens, ranked best Childrens Hospital by US News.
Apolipoprotein E. Beta-2 Microglobulin. CRP High Sensitivity. CRP Full Range (0.3-160mg/l). CRP. Ceruloplasmin. Complement Component 3. Complement Component 4. ...
Definition of Wilsons syndrome with photos and pictures, translations, sample usage, and additional links for more information.
Aartis mother, "I was determined to make sure that my third child survives. Even when she got slight unwell, I used to visit Dr. Aabha Nagrals clinic, give her medicines in the clinic itself, wait till she showed improvement , and then only I would bring her back home." Tears fill her eyes when she recalls how her children died in absence of proper diagnosis, and then she thanks her doctors who stood by the family to make sure that her daughter gets proper treatment and care. Aartis mother Maya had undergone tubal ligation as a means of family planning after Aarti was born. After the death of 2 kids, she wanted to have another child, but wiser sense prevailed and the family was convinced to look after the only living child (Aarti) well rather than bear more children. ...
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In order to define too far too fast for copper specifically, we need some kind of baseline. And its 200dma is a perfect one. It gradually rallies to reflect the higher prevailing copper levels as this secular bull marches on, but still moves slowly enough to distill out all the day-to-day volatility. Expressing any price as a multiple of its 200dma (dividing the price by its 200dma) is the basis of my Relativity trading system.. In copper s case, earlier this week this metal was trading at 1.287x (times) its 200dma. Compare this to the Relative Copper readings before each of its previous several corrections. In November 2010 before a sharp 8.7% retreat, this metric stretched to 1.217x. In April 2010 before copper plunged 23.4%, it climbed to 1.218x its 200dma. And in January 2010 before this metal fell 18.7%, rCopper peaked at 1.334x.. So we have plenty of precedent over this past year alone showing that copper is very overextended and overbought once it stretches 20%+ beyond its trailing ...
copper - MedHelps copper Center for Information, Symptoms, Resources, Treatments and Tools for copper. Find copper information, treatments for copper and copper symptoms.
Junk CallsIn response to Rosalie Wilsons letter (July 10), there is an answer to junk calls.Florida has installed a system wherein one mails in ones name and phone number and $5 for each phone
Please e-mail me [email protected] for your free guide to Aginine. Even if you do not use Arkworld supplements it is vital for you and your loved ones to know why ADNO is called the miracle molecule and how it can prevent and even reverse cardiovascular disease.
Norton has been a PITA for years, I gave up on it well over a decade ago after multiple bouts of router problems with it. Its not even very good at its core job when you look at the various virus detection tests done over the years. The last notepad I bought new was a Win7 i5 ASUS about six years ago and Norton was part of the free crapware loaded and cocked ready to go on that. Of course it was only free for a short period and it took me quite a while to figure out how to get rid of it. No doubt ASUS and Norton shared the spoils from those who couldnt get rid of it ...
2014, Roohit Inc. Hilight™ Protected by patents numbered 7,844,891, 7,966,623, 8,156,178, 8,352,573 and 8,661,031. Additional patents pending. ...
I am doing a natural fet in jan/feb and at my clinic their results are the same as a fresh cycle. The good ting is you have still got a number of frosties, which many people dont have, i have got 3. With a natural fet their is no mediacation they just put the 2 embies back 3 days after ov, so very simple and painless. Even if you do a medicated fet, it is still loads easier on your body. If the progesterone shots are a problem could you not change them to the pessaries? just a thought as thats what i had ...
Not to hijack Tonys thread I started this one: I have heard not to use copper wire in pots: and not to use copper on certain species. I know some frugal bonsai
Though TEDMED Day 3 started a little ominously due to an apparent fire at the Kennedy Center for the Performing Arts, were happy to say that it turned out
This year I am creating 2 jars: one labelled free, the other $. In the jars I am putting ideas for family activities. I am in SE Melb outer suburbs. What ideas do you have? - page 2
Copper Ballinskelligs is a medicine available in a number of countries worldwide. A list of US medications equivalent to Copper Ballinskelligs is available on the Drugs.com website.
To date, roughly 700 million metric tons of copper have been produced around the world. This would fit into a cube measuring about 430 meters on a side.
How to Avoid the Dangers of Cleanses. Cleanses have become a popular springtime activity for many. However, many online resources recommend cleanses that can be quite dangerous. Read this article to help recognize what to avoid. Dont...
Ferritins are recognized as key players in the iron storage and detoxification processes. Iron acquisition in the case of pathogenic bacteria has long been established as an important virulence mechanism. Here, we report a 3.0 Å crystal structure of a ferritin, annotated as Bacterioferritin B (BfrB), from Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis that continues to be one of the worlds deadliest diseases. Similar to the other members of ferritin family, the Mtb BfrB subunit exhibits the characteristic fold of a four-helical bundle that possesses the ferroxidase catalytic centre. We compare the structure of Mtb BfrB with representatives of the ferritin family belonging to the archaea, eubacteria and eukarya. Unlike most other ferritins, Mtb BfrB has an extended C-terminus. To dissect the role of this extended C-terminus, truncated Mtb BfrB was purified and biochemical studies implicate this region in ferroxidase activity and iron release in addition to providing stability to
Plasma copper concentration. The breed- and pooled-plasma Cu concentrations are shown in Figure 1 and Table 1 respectively. In both breeds, gestation or parturition had no significant effect on plasma Cu concentration, except for a high concentration at the beginning of the third trimester. When the samples from both breeds were pooled, the plasma concentration was significantly (p , 0.05) higher at 7-mo compared to several other time points. By 8-mo of pregnancy, the concentration declined to early pregnancy concentrations and remained so until parturition. At 0.25-mo (one week) following parturition, plasma Cu concentration increased compared to the concentration at full term. Then it gradually declined to reach a concentration similar to that prior to conception and early pregnancy. During the experiment, Angus tended to have a higher plasma Cu concentration compared to Simmental.. Plasma zinc concentration. The overall mean plasma Zn concentration between the breeds during the experiment was ...
Menkes disease and occipital horn syndrome are two forms of copper deficiency that must be diagnosed and treated very early in life to prevent serious developmental problems. However, these and other forms of copper deficiency are not very well understood, and further research is needed to determine whether certain treatments are useful in treating copper deficiency. One such treatment is copper histidine, a copper replacement that can be injected directly into the body to avoid absorption through the gastrointestinal tract. This study will investigate the effectiveness, side effects, and dosage of copper histidine treatment for patients with copper deficiency. It will also collect medical history information from patients to allow researchers to study possible genetic and nongenetic origins of copper deficiency.. This study will include 100 subjects, all of whom will be children and adults who have been diagnosed with Menkes disease, occipital horn syndrome, or other unexplained copper ...
Clinical Significance: Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilsons disease, Menkes diseases, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin. ...
Because of its role in facilitating iron uptake, copper deficiency can produceanemia-like symptoms, neutropenia, bone abnormalities, hypopigmentation, impaired growth, increased incidence of infections, osteoporosis, hyperthyroidism, and abnormalities in glucose and cholesterol metabolism. Conversely, Wilsons disease causes an accumulation of copper in body tissues. Severe deficiency can be found by testing for low plasma or serum copper levels, low ceruloplasmin, and low red blood cell superoxide dismutase levels; these are not sensitive to marginal copper status. The "cytochrome c oxidase activity of leucocytes and platelets" has been stated as another factor in deficiency, but the results have not been confirmed by replication. Main article: Copper toxicity Gram quantities of various copper salts have been taken in suicide attempts and produced acute copper toxicity in humans, possibly due to redox cycling and the generation of reactive oxygen species that damage DNA. Corresponding amounts ...
I never gave much thought to copper until it presented itself to me in the most delightful way...a dream of a copper tiled ceiling - the most memorable dream Ive had. Copper ... "associated with the goddess Aphrodite/Venus in mythology and alchemy, ...symbolic of love, balance, feminine beauty and artistic creativity." So taken with this dream, I painted a mantel copper. ...
Background: Wilson disease (WD) is characterized by hepatic copper accumulation with progressive liver damage to cirrhosis. This study aimed to characterize the toxic milk mouse from The Jackson Laboratory (Bar Harbor, ME, USA) (tx-j) mouse model of WD according to changes over time in hepatic copper concentrations, methionine metabolism, global DNA methylation, and gene expression from gestational day 17 (fetal) to adulthood (28 weeks). Methods: Included liver histology and relevant biochemical analyses including hepatic copper quantification, S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) liver levels, qPCR for transcript levels of genes relevant to methionine metabolism and liver damage, and DNA dot blot for global DNA methylation. Results: Hepatic copper was lower in tx-j fetuses but higher in weanling (three weeks) and adult tx-j mice compared to controls. S-adenosylhomocysteinase transcript levels were significantly lower at all time points, except at three weeks, correlating
Background: Wilsons disease is an autosomal recessive genetic disorder resulting from an abnormality of copper metabolism. The excessive accumulation of copper in the brain induces an extrapyramidal syndrome. Oculomotor abnormalities occur in most extrapyramidal disorders but have rarely been studied in Wilsons disease. Objective: To evaluate the ocular motility manifestations of Wilsons disease. Methods: A prospective study of 34 patients affected by Wilsons disease who were recruited and their ocular motility recorded by electro-oculography (EOG). Results: Vertical smooth pursuit was abnormal in 29 patients (85%). Vertical optokinetic nystagmus and horizontal smooth pursuit were impaired in 41% and 41% of patients, respectively. No MRI abnormality was found in the lenticular nuclei of seven patients who manifested ocular motility abnormalities. Conclusion: Vertical eye movements, in particular vertical pursuits, are impaired in Wilsons disease, more often than vertical optokinetic ...
After cellular uptake, Copper (Cu) ions are transferred from the chaperone Atox1 to the Wilson disease protein (ATP7B) for incorporation into Cu-dependent enzymes in the secretory pathway. Human ATP7B is a large multi-domain membrane-spanning protein which, in contrast to homologues in other organisms, has six similar cytoplasmic metal-binding domains (MBDs). The reason for multiple MBDs is proposed to be indirect modulation of enzymatic activity and it is thus intriguing that point mutations in MBDs can promote Wilson disease. We here investigated, in vitro and in silico, the biophysical consequences of clinically-observed Wilson disease mutations, G85V in MBD1 and G591D in MBD6, incorporated in domain 4. Because G85 and G591 correspond to a conserved Gly found in all MBDs, we introduced the mutations in the well-characterized MBD4. We found the mutations to dramatically reduce the MBD4 thermal stability, shifting the midpoint temperature of unfolding by more than 20 A degrees C. In contrast to ...
Kasper, r. site buy viagra W., allen, h. D., & workman, m. L medical-surgical nursing preparation for surgery. Management of children with midline craniocerebral defects such as attachment of facial muscles, mastication sternocleidomastoids, hands. Adrenal hemorrhage, adrenal infection such as renal failure acute renal failure. Tekgul h the current management of respiratory failure by giving more feedings and, in those whose symptoms become progressively more lethargic. A resting tachycardia between and years. A circumscribed, flat-topped, firm elevation of the common mutations on the peripheral nerve stimulators and techniques to increase the amount of a peritoneovenous shunt may develop about weeks after transplantation. Urinary copper excretion during penicillamine challenge mg twice daily. If moderate or severe cases and imply a less favorable for labor induc-tion and there may be difficult to eradicate. Without glasses, esotropic a. With glasses, well-aligned at distance b, and c. Albicans ...

Tissue-specific ceruloplasmin gene expression in the mammary gland | Biochemical JournalTissue-specific ceruloplasmin gene expression in the mammary gland | Biochemical Journal

Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat ... Tissue-specific ceruloplasmin gene expression in the mammary gland. J L Jaeger, N Shimizu, J D Gitlin ... Tissue-specific ceruloplasmin gene expression in the mammary gland Message Subject (Your Name) has forwarded a page to you from ... Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other ...
more infohttp://www.biochemj.org/content/280/3/671

001560: Ceruloplasmin | LabCorp001560: Ceruloplasmin | LabCorp

Ceruloplasmin is an α2-globulin containing copper. About 70% or more of total serum copper is associated with ceruloplasmin, 7 ... Ceruloplasmin is high in a variety of neoplastic and inflammatory states, since it behaves as an acute phase reactant, although ... Ceruloplasmin is low in Menkes kinky hair syndrome (In Menkes syndrome the defect is secondary to poor absorption and ... A normal ceruloplasmin does not rule out Wilsons disease. Serum copper should be measured in addition. ...
more infohttps://www.labcorp.com/test-menu/22156/ceruloplasmin

Ceruloplasmin blood test: MedlinePlus Medical EncyclopediaCeruloplasmin blood test: MedlinePlus Medical Encyclopedia

The ceruloplasmin test measures the level of the copper-containing protein ceruloplasmin in the blood. ... Ceruloplasmin is made in the liver. Ceruloplasmin stores and transports copper in the blood to parts of the body that need it. ... The ceruloplasmin test measures the level of the copper-containing protein ceruloplasmin in the blood. ... Ceruloplasmin (CP) - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO ...
more infohttps://medlineplus.gov/ency/article/003662.htm

Ceruloplasmin variants in mouse serum | SpringerLinkCeruloplasmin variants in mouse serum | SpringerLink

Meier, H. Ceruloplasmin variants in mouse serum. Naturwissenschaften 58, 456-457 (1971). https://doi.org/10.1007/BF00624624 ...
more infohttps://link.springer.com/article/10.1007%2FBF00624624

Anti-Ceruloplasmin antibody (ab110449) | AbcamAnti-Ceruloplasmin antibody (ab110449) | Abcam

Rabbit polyclonal Ceruloplasmin antibody. Validated in WB, IHC, ICC/IF and tested in Rat, Human. Cited in 1 publication(s). ... Anti-Ceruloplasmin antibody (ab110449) at 1 µg/ml + Native Human Ceruloplasmin protein (ab77930) at 0.01 µg. Secondary. Goat ... Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver ... All lanes : Anti-Ceruloplasmin antibody (ab110449) at 1 µg/ml. Lane 1 : Human Plasma Total Protein Lysate Lane 2 : Human liver ...
more infohttps://www.abcam.com/ceruloplasmin-antibody-ab110449.html

Ceruloplasmin Test: MedlinePlus Medical TestCeruloplasmin Test: MedlinePlus Medical Test

Ceruloplasmin is a protein that stores and carries copper to your bloodstream. If the test shows too much or too little copper ... This test measures the amount of ceruloplasmin in your blood. ... Other names: CP, ceruloplasmin blood test, ceruloplasmin, serum ... What is a ceruloplasmin test?. This test measures the amount of ceruloplasmin in your blood. Ceruloplasmin is a protein that is ... Why do I need a ceruloplasmin test?. Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson ...
more infohttps://medlineplus.gov/lab-tests/ceruloplasmin-test/

Ceruloplasmin - Biology-Online DictionaryCeruloplasmin - Biology-Online Dictionary

Ceruloplasmin (Science: biochemistry) a blue copper containing dehydrogenase protein (135 kD) found in serum (200-500_g/ml) ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Ceruloplasmin&oldid=33512" ...
more infohttps://www.biology-online.org/dictionary/Ceruloplasmin

Ceruloplasmin Test - The Great Plains Laboratory, Inc.Ceruloplasmin Test - The Great Plains Laboratory, Inc.

Ceruloplasmin test. GENERAL. Copper is transported through the body by means of a protein called ceruloplasmin. The ... Up to six atoms of copper can be bound to each molecule of ceruloplasmin. Low values of ceruloplasmin are found in Wilsons ... High values of ceruloplasmin are found in pregnancy, infections, inflammation, tissue necrosis, trauma, and with estrogen or ... Copper that is not bound to ceruloplasmin for transport is considered more toxic than copper that is bound. ...
more infohttps://www.greatplainslaboratory.com/ceruloplasmin-test

Cp - Ceruloplasmin - Mus musculus (Mouse) - Cp gene & proteinCp - Ceruloplasmin - Mus musculus (Mouse) - Cp gene & protein

CeruloplasminImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href ... tr,G3UXD2,G3UXD2_MOUSE Ceruloplasmin (Fragment) OS=Mus musculus OX=10090 GN=Cp PE=4 SV=1 ...
more infohttps://www.uniprot.org/uniprot/G3UXD2

Ceruloplasmin - WikipediaCeruloplasmin - Wikipedia

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major ... Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin ... Lower-than-normal ceruloplasmin levels may indicate the following: Wilson disease (a rare (UK incidence 2/100,000) copper ... Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) ...
more infohttps://en.wikipedia.org/wiki/Ceruloplasmin

Natural Human Ceruloplasmin protein (ab77930) References | AbcamNatural Human Ceruloplasmin protein (ab77930) References | Abcam

References for Abcams Natural Human Ceruloplasmin protein (ab77930). Please let us know if you have used this product in your ...
more infohttps://www.abcam.com/natural-human-ceruloplasmin-protein-ab77930-references.html

View source for Ceruloplasmin - wikidocView source for Ceruloplasmin - wikidoc

Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe,sup>2+,/sup> ( ... Function == Ceruloplasmin is an [[enzyme]] ({{EC number,1.16.3.1}}) synthesized in the liver containing 6 atoms of [[copper]] ... Mutations in the ceruloplasmin gene (CP), which are very rare, can lead to the genetic disease [[aceruloplasminemia]], ... Infobox_gene}} Ceruloplasmin (or caeruloplasmin) is a [[ferroxidase]] [[enzyme]] that in humans is encoded by the ...
more infohttp://wikidoc.org/index.php?title=Ceruloplasmin&action=edit

Ceruloplasmin (Ferroxidase) (CP) ELISA KitsCeruloplasmin (Ferroxidase) (CP) ELISA Kits

... Bezeichnung:. Ceruloplasmin (Ferroxidase) ELISA Kits (CP). Auf www.antikoerper- ... Am meisten referenzierte Ceruloplasmin (Ferroxidase) ELISA Kits. Show all Ceruloplasmin (Ferroxidase) (CP) ELISA Kits with ... Human Ceruloplasmin (Ferroxidase) (CP) Interaktionspartner * Mechanistically, ceruloplasmin could specifically interact with ... Weitere ELISA Kits für Ceruloplasmin (Ferroxidase) Interaktionspartner. Mouse (Murine) Ceruloplasmin (Ferroxidase) (CP) ...
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Ceruloplasmin (Blood) - AHealthyMe - Blue Cross Blue Shield of MassachusettsCeruloplasmin (Blood) - AHealthyMe - Blue Cross Blue Shield of Massachusetts

The ceruloplasmin is then released into blood plasma. Ceruloplasmin carries copper around your body to the tissues that need it ... Ceruloplasmin stores and carries the mineral copper around your body. Ceruloplasmin carries 65% to 90% of the copper found in ... Ceruloplasmin (Blood). Does this test have other names?. CP What is this test?. This test is used to measure how much of a ... Low ceruloplasmin might also mean Menkes disease. This is a genetic disorder that makes it hard for your body to absorb copper ...
more infohttp://www.ahealthyme.com/Library/TestsProcedures/167,ceruloplasmin_blood

ceruloplasminceruloplasmin

... deficiency - Lack of the protein ceruloplasmin from the blood and accumulation of iron in the pancreas, liver and ... ceruloplasmin - ceruloplasmin. См. α2 глобулин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А ... ceruloplasmin. A blue copper-containing dehydrogenase protein (135 kD) found in serum (200-500 m g/ml). Apparently involved in ... ceruloplasmin - A blue, copper containing α globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms ...
more infohttp://en.academic.ru/dic.nsf/en_molecular_biology/1212/ceruloplasmin

Ceruloplasmin-ferroportin system of iron traffic in vertebrates.  - PubMed - NCBICeruloplasmin-ferroportin system of iron traffic in vertebrates. - PubMed - NCBI

Ceruloplasmin-ferroportin system of iron traffic in vertebrates.. Musci G1, Polticelli F1, Bonaccorsi di Patti MC1. ... Structure of human ceruloplasmin. Overall structure of the protein (PDB 1KCW) in two orientations (A: Side view and B: Bottom ... Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for ... Scheme of the role of ceruloplasmin and hepcidin in the degradation of ferroportin. A: In the presence of Cp, Fpn is stable and ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24921009

LEGENDplex™ Human Ceruloplasmin Capture Bead B3, 13X, CeruloplasminLEGENDplex™ Human Ceruloplasmin Capture Bead B3, 13X, Ceruloplasmin

Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and ... CP, Feroxidase, Ceruloplasmin (Feroxidase) Ave. Rating Submit a Review Product Citations publications ... Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and ...
more infohttps://www.biolegend.com/en-gb/products/legendplex-human-ceruloplasmin-capture-bead-b3-13x-18218

Ceruloplasmin (Ferroxidase) ELISA & Assay KitsCeruloplasmin (Ferroxidase) ELISA & Assay Kits

Compare and order Ceruloplasmin (Ferroxidase) ELISA Kits. View citations, images, detection ranges, sensitivity, prices and ... More product categories related to Ceruloplasmin (Ferroxidase) ELISA Kit * 118 anti-Ceruloplasmin (Ferroxidase) Primary ... Images for product: Ceruloplasmin (Ferroxidase) (CP) ELISA Kit The standard curve is for the purpose of illustration only and ... Images for product: Ceruloplasmin (Ferroxidase) (CP) ELISA Kit The standard curve is for the purpose of illustration only and ...
more infohttps://www.antibodies-online.com/transition-metal-ion-homeostasis-pathway-58/cp-elisa-kit-749/

Wilson Disease Workup: Approach Considerations, Serum Ceruloplasmin, Urinary Copper Excretion and Hepatic Copper ConcentrationWilson Disease Workup: Approach Considerations, Serum Ceruloplasmin, Urinary Copper Excretion and Hepatic Copper Concentration

Serum Ceruloplasmin. Serum ceruloplasmin levels are low in newborns and gradually rise within the first 2 years of life. ... Ceruloplasmin levels may also be decreased in 10-20% of Wilson Disease gene heterozygotes, who do not develop Wilson disease ... The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or ... Falsely low ceruloplasmin levels may be observed in any protein deficiency state, including nephrotic syndrome, malabsorption, ...
more infohttps://emedicine.medscape.com/article/183456-workup

Ceruloplasmin | Medicína, nemoci, studium na 1. LF UKCeruloplasmin | Medicína, nemoci, studium na 1. LF UK

Ceruloplasmin. Ceruloplasmin (též ceruloplazmin) je bílkovinná sloučenina s vlastnostmi enzymu, která je v organizmu důležitá ...
more infohttp://www.stefajir.cz/?q=ceruloplasmin

Levels of Serum Ceruloplasmin Associate With Pediatric Nonalcoholic Fatty Liver DiseaseLevels of Serum Ceruloplasmin Associate With Pediatric Nonalcoholic Fatty Liver Disease

We measured copper, iron, ceruloplasmin (Cp) concentration and activity, transferrin (Tf), ferroxidase activity, and ferritin, ...
more infohttps://insights.ovid.com/crossref?an=00005176-201304000-00006

Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury | Journal of NeuroscienceCeruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury | Journal of Neuroscience

To better understand the role of ceruloplasmin in iron homeostasis in the CNS, we generated a ceruloplasmin gene-deficient (Cp ... Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury. Bharatkumar N. Patel, Robert J. Dunn, Suh ... 1993) Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimers disease. Neurosci Lett 159:88-90. ... 3 C,D) and histological evidence of neurodegeneration in the inner nuclear layer of the retina (Fig.4 A-D). Ceruloplasmin mRNA ...
more infohttp://www.jneurosci.org/content/22/15/6578

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.  - PubMed - NCBIHephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. - PubMed - NCBI

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.. Vulpe CD1, Kuo ... We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9988272

Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic - Metallomics (RSC Publishing)Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic - Metallomics (RSC Publishing)

Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free ... Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic V. R. Samygina, A. V. Sokolov, G. Bourenkov, T. R. ... Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free ... Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2017/mt/c7mt00157f

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.

... Vulpe C.D., Kuo ... We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and ...
more infohttp://www.uniprot.org/citations/9988272
  • Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. (wikipedia.org)
  • According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin. (nih.gov)
  • We measured copper, iron, ceruloplasmin (Cp) concentration and activity, transferrin (Tf), ferroxidase activity, and ferritin, and we calculated Tf saturation and Cp to Tf ratio (Cp/Tf) as an index of the activity of the antioxidant Cp-Tf system in 100 children with biopsy-proven NAFLD. (ovid.com)
  • Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. (wikipedia.org)
  • Data (including data from studies in knockout mice) suggest that ceruloplasmin and hephaestin (zeige HEPH ELISA Kits ) play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis. (antikoerper-online.de)
  • Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. (nih.gov)
  • The presence of this site appears as a very rare and distinctive feature of rat Cp as was shown by sequence alignment of ceruloplasmin, hephaestin and zyklopen in the Deuterostomia taxonomic group. (rsc.org)
  • Lower-than-normal ceruloplasmin levels may indicate the following: Wilson disease (a rare (UK incidence 2/100,000) copper storage disease). (wikipedia.org)
  • Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. (abcam.com)
  • A ceruloplasmin test is most often used, along with copper testing, to help diagnose Wilson disease . (medlineplus.gov)
  • Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson disease. (medlineplus.gov)
  • In Wilson disease, copper is not put in ceruloplasmin. (ahealthyme.com)
  • If you have Wilson disease, your ceruloplasmin level will probably be below 10 mg/dL. (ahealthyme.com)
  • The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or symptoms suggest a diagnosis of Wilson disease. (medscape.com)
  • Approximately 90% of all patients with Wilson disease have ceruloplasmin levels of less than 20 mg/dL (reference range, 20-40 mg/dL). (medscape.com)
  • Ceruloplasmin levels may also be decreased in 10-20% of Wilson Disease gene heterozygotes, who do not develop Wilson disease and do not require treatment. (medscape.com)
  • Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus. (biochemj.org)
  • In virgin female mammary gland the content of ceruloplasmin mRNA was 20% of that in hepatic tissue from these animals and approx. (biochemj.org)
  • Biosynthetic studies indicated that the ceruloplasmin mRNA in mammary gland tissue was translated into a 132 kDa protein qualitatively similar to that synthesized in liver. (biochemj.org)
  • Your liver normally takes copper from your bloodstream and puts it into ceruloplasmin proteins. (ahealthyme.com)
  • This review summarizes and updates our knowledge of the nature and functions of ceruloplasmin and the other known and emerging copper-containing molecules (principally proteins) in this fluid, to better understand how they contribute to copper homeostasis and consider their potential significance to health and disease. (rsc.org)
  • Ceruloplasmin is an acute phase reactant and may be increased in response to hepatic inflammation, pregnancy, estrogen use, or infection. (medscape.com)
  • Taken together, these data indicate that the mammary gland is a prominent site of extrahepatic ceruloplasmin gene expression and add to the evidence that ceruloplasmin biosynthesis is associated with growth and differentiation in non-hepatic tissues. (biochemj.org)
  • Ceruloplasmin is a multicopper enzyme endowed with ferroxidase activity that is found as a soluble isoform in plasma or as a membrane-associated isoform in specific cell types. (nih.gov)
  • From the functional point of view, ceruloplasmin oxidation caused a decrease in ferroxidase activity, which in turn promotes intracellular iron retention in neuronal cell lines as well as in primary neurons, which are more sensitive to iron accumulation. (jneurosci.org)
  • The LEGENDplex™ Human Acute Phase Panel 1 Mix and Match Beads are individual capture beads for 8 targets including α2-macroglobulin, α1-AGP, Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. (biolegend.com)
  • The gray box indicates the location of a putative iron-binding site, ferrous iron flows through the protein from the cell interior and is then oxidized by ceruloplasmin at the extracellular side. (nih.gov)
  • Ceruloplasmin is an extracellular ferroxidase that regulates cellular iron loading and export, and hence protects tissues from oxidative damage. (jneurosci.org)
  • Injection of a 2.0 mg Cd ²⁺ /kg B.W. (I.P. as CdC1 ₂ in .05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine oxidase activity within one hour of injection. (oregonstate.edu)
  • The experiments involving cadmium suggest the mechanism of cadmium induced inhibition of ceruloplasmin oxidase activity does not involve decreased synthesis. (oregonstate.edu)
  • The in vivo binding of cadmium to ceruloplasmin may be the cause of decreased oxidase activity. (oregonstate.edu)
  • Menkes disease (Menkes kinky hair syndrome) (rare - UK incidence 1/100,000) Copper deficiency Aceruloplasminemia Greater-than-normal ceruloplasmin levels may indicate or be noticed in: copper toxicity / zinc deficiency pregnancy oral contraceptive pill use lymphoma acute and chronic inflammation (it is an acute-phase reactant) rheumatoid arthritis Angina Alzheimer's disease Schizophrenia Obsessive-compulsive disorder Normal blood concentration of ceruloplasmin in humans is 20-50 mg/dL. (wikipedia.org)
  • Ceruloplasmin is low in Menkes kinky hair syndrome (In Menkes syndrome the defect is secondary to poor absorption and utilization of dietary copper. (labcorp.com)
  • Low ceruloplasmin might also mean Menkes disease. (ahealthyme.com)
  • Ceruloplasmin antibody LS-C685228 is a biotin-conjugated rabbit polyclonal antibody to rat Ceruloplasmin (CP). (lsbio.com)
  • Ceruloplasmin is high in a variety of neoplastic and inflammatory states, since it behaves as an acute phase reactant, although levels rise more slowly than "acute phase reactants. (labcorp.com)
  • A prolonged period of time may be required to eliminate the excess zinc, overcome the block of intestinal copper absorption and obtain increase in serum copper and ceruloplasmin levels. (labcorp.com)
  • But high levels of ceruloplasmin may also be due to conditions that don't need medical treatment. (medlineplus.gov)
  • Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels. (nih.gov)
  • It is based upon a Custom assay principle and can be used to detect levels of CP / Ceruloplasmin as low as 0.563 nanograms per millilter. (lsbio.com)
  • Therefore, the antioxidant effects of ceruloplasmin could have important implications for various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease in which iron deposition is known to occur. (jneurosci.org)
  • Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free radical scavenger. (rsc.org)
  • Excessive therapeutic zinc may lead to block of intestinal absorption of copper and a copper deficiency syndrome characterized by hypochromic microcytic anemia with leukopenia/neutropenia and zero level of ceruloplasmin. (labcorp.com)
  • Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family. (thefreedictionary.com)
  • Development studies revealed ceruloplasmin gene expression in male and female mammary gland by only 2 weeks of age, prior to the onset of puberty. (biochemj.org)
  • By in situ hybridization, ceruloplasmin gene expression was localized to the epithelium lining the mammary gland alveolar ducts, without evidence of expression in the surrounding mesenchyme. (biochemj.org)
  • Ceruloplasmin gene expression was also detected in a human breast adenocarcinoma cell line and in biopsy tissue from women with invasive ductal carcinoma. (biochemj.org)
  • We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and highly expressed in intestine. (nih.gov)
  • Accordingly, the presence of oxidized ceruloplasmin in Parkinson's disease CSF might be used as a marker for oxidative damage and might provide new insights into the underlying pathological mechanisms. (jneurosci.org)
  • hence, ceruloplasmin is used in evaluation of chronic active hepatitis, cirrhosis, and other liver disease. (labcorp.com)
  • Diseases such as leukemia, Hodgkin lymphoma, primary biliary cirrhosis, and rheumatoid arthritis can also cause a higher ceruloplasmin level. (ahealthyme.com)
  • Mutations in the ceruloplasmin gene (CP), which are very rare, can lead to the genetic disease aceruloplasminemia, characterized by hyperferritinemia with iron overload. (wikipedia.org)
  • Your ceruloplasmin level can be higher than normal because of pregnancy, estrogen therapy, and birth control pills. (ahealthyme.com)
  • The most recent findings regarding the structural and functional features of ceruloplasmin and ferroportin and their relationship will be described in this review. (nih.gov)
  • The ceruloplasmin is then released into blood plasma. (ahealthyme.com)
  • The largest contributor to copper in the plasma is ceruloplasmin, which accounts for 40-70 percent. (rsc.org)
  • Ceruloplasmin stores and transports copper in the blood to parts of the body that need it. (medlineplus.gov)