A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
A transient dilatation of the lymphatic vessels.
A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)
The concrete oleoresin obtained from Pinus palustris Mill. (Pinaceae) and other species of Pinus. It contains a volatile oil, to which its properties are due, and to which form it is generally used. (Dorland, 28th ed) Turpentine is used as a solvent and an experimental irritant in biomedical research. Turpentine toxicity is of medical interest.
Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.
The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).
A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Serum globulins with high molecular weight. (Dorland, 28th ed)
3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. This strain is a model for Wilson's Disease (see HEPATOLENTICULAR DEGENERATION).
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.
The protein components of ferritins. Apoferritins are shell-like structures containing nanocavities and ferroxidase activities. Apoferritin shells are composed of 24 subunits, heteropolymers in vertebrates and homopolymers in bacteria. In vertebrates, there are two types of subunits, light chain and heavy chain. The heavy chain contains the ferroxidase activity.
A United States organization of distinguished scientists and engineers established for the purpose of investigating and reporting upon any subject of art or science as requested by any department of government. The National Research Council organized by NAS serves as the principal operating agency to stimulate and support research.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.
A branch of psychology which investigates the correlation between experience or behavior and the basic neurophysiological processes. The term neuropsychology stresses the dominant role of the nervous system. It is a more narrowly defined field than physiological psychology or psychophysiology.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The measurement of magnetic fields generated by electric currents from the heart. The measurement of these fields provides information which is complementary to that provided by ELECTROCARDIOGRAPHY.
The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The dialdehyde of malonic acid.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
MAMMARY GLANDS in the non-human MAMMALS.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).

The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase antibodies. (1/796)

BACKGROUND: The purpose of this study was to characterize the recently reported inhibition of myeloperoxidase (MPO) by ceruloplasmin and to determine whether this may be disturbed in the presence of anti-MPO antibodies. METHODS: Specificity of the binding between ceruloplasmin and MPO was confirmed by Western blotting and enzyme-linked immunosorbent assay (ELISA), and the enzymatic activity of MPO was measured in the presence of ceruloplasmin, affinity-purified anti-MPO antibodies, or both. The affinity of the binding between MPO and ceruloplasmin and MPO and the anti-MPO antibodies was measured using a biosensor, with the results confirmed by chaotrope ELISA. RESULTS: Affinity-purified anti-MPO antibodies from patients with microscopic polyangiitis and florid renal vasculitis inhibited the binding between ceruloplasmin and MPO to a maximum of 72.9 +/- 12.8%, whereas those from patients with Wegener's granulomatosis and only minimal renal involvement inhibited the binding to a maximum of only 36.8 +/- 10.9% (P < 0. 001), with comparable reversal of the ceruloplasmin-mediated inhibition of MPO activity. Measurement of the affinity of the interactions demonstrated that binding between MPO and the anti-MPO antibodies is stronger than that between MPO and ceruloplasmin (1.61 x 107 to 1.33 x 108 vs. 7.46 x 106 m-1), indicating that binding to the autoantibody would be favored in vivo. CONCLUSIONS: This study confirms a role for ceruloplasmin as a physiological inhibitor of MPO, and demonstrates how the inhibition may be disrupted in the presence of anti-MPO antibodies. Because a majority (16 of 21) of the antibodies did not themselves inhibit MPO activity, their interference with the inhibition mediated by ceruloplasmin may be brought about by steric hindrance consequent upon the binding of the antibody to a dominant epitope at or near the active site.  (+info)

Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation. (2/796)

It is widely accepted that iron deposition in the iron storage protein ferritin in vitro involves Fe(II) oxidation, and that ferritin facilitates this oxidation at a ferroxidase site on the protein. However, these views have recently been questioned, with the protein ferroxidase activity instead being attributed to autoxidation from the buffer alone. Ligand exchange between another protein with ferroxidase activity and ferritin has been proposed as an alternative mechanism for iron incorporation into ferritin. In the present work, a pH stat apparatus is used to eliminate the influence of buffers on iron(II) oxidation. Here we show that the recent experiments questioning the ferroxidase activity of ferritin were flawed by inadequate pH control, that buffers actually retard rather than facilitate iron(II) oxidation, and that horse spleen ferritin has ferroxidase activity when measured under proper experimental conditions. Furthermore, high pH (7.0), a high Fe(II) concentration and the presence of Fe(III) all favour Fe(II) autoxidation in the presence or absence of ferritin.  (+info)

Copper metabolism in retinitis pigmentosa. (3/796)

Clinically and electrophysiologically confirmed cases of primary retinitis pigmentosa have been investigated regarding their copper metabolic state. It is observed that these patients show a normal or near normal serum copper concentration, very low plasma caeruloplasmin concentration, and a very high copper urinary excretion. A similarity between this condition and hepatolenticular degeneration is drawn and it is suggested that retinitis pigmentosa may also be a condition caused by an inborn error of copper metabolism.  (+info)

Caeruloplasmin isoforms in Wilson's disease in neonates. (4/796)

AIM: To investigate the neonatal diagnosis of Wilson's disease from caeruloplasmin isoforms in cord blood. METHODS: Serum caeruloplasmin isoforms were measured in 5-10 ml cord blood from 10 fresh umbilical cords using sodium dodecyl polyacrylamide gel electrophoresis (SDS PAGE) and western blotting and analysed by densitometry. Total caeruloplasmin concentrations were determined by nephelometry and caeruloplasmin oxidase by p-nitrophenyldiamine. RESULTS: Although total caeruloplasmin concentrations are reduced in neonates, the plasma isoform was significantly reduced or absent in patients with Wilson's disease. Sera from healthy neonates and from those with Wilson's disease had reduced biliary isoforms. CONCLUSION: Identification of caeruloplasmin isoforms may be a marker for Wilson's disease in neonates.  (+info)

The reactions of copper proteins with nitric oxide. (5/796)

Nitric oxide (NO) can act as a ligand for copper atoms and may also engage in redox chemistry with the metal once bound. Furthermore NO posses an unpaired electron which can couple with the unpaired electron on Cu2+. These properties have been exploited to probe the active sites of copper-containing enzymes and proteins. We review these studies. In addition to the use as a spectroscopic probe for the active site we draw attention to the rapid reactions of NO at the copper sites in Cytochrome c oxidase (CcO) and laccase. These reactions in CcO occur in the ms time range, at low NO concentrations and in the presence of oxygen and may therefore be of physiological relevance to the control of respiration. Finally we speculate on the wider role that NO may play in regulation of an important group of Type 2 copper containing enzymes.  (+info)

Abnormality in urinary protein excretion in Japanese men with impaired glucose tolerance. (6/796)

OBJECTIVE: To examine whether subjects with impaired glucose tolerance (IGT) for more than 2 years have any abnormality in the kidney. RESEARCH DESIGN AND METHODS: We measured urinary excretion rate and clearance of various plasma proteins with different molecular radii and different isoelectric points in 22 Japanese men with IGT (IGT group) and 37 age-matched healthy control subjects (control group). RESULTS: Clearance of ceruloplasmin (molecular radius approximately 45 A; isoelectric point 4.4), IgG4 (molecular radius 55 A; isoelectric point 5.4), and IgG (molecular radius 55 A; isoelectric point 7.4) was significantly higher in the IGT group than in the control group, whereas there were no significant differences in urinary excretion rate of albumin (molecular radius 36 A; isoelectric points 4.8-5.2) and clearance of alpha 2-macroglobulin (molecular radius 88 A; isoelectric point 5.4) between the two groups. CONCLUSIONS: In the present study, we found that clearance of neutral-charged IgG, negatively charged IgG4, and ceruloplasmin with molecular radii of approximately 45-55 A was selectively increased in IGT subjects. This finding does not seem to be explained by impairment of charge and pore-size selectivity in the glomerulus. Therefore, considering the present result together with our recent finding that enhanced glomerular filtration rate (GFR) after acute protein loading in healthy subjects induced a selective increase in clearance of IgG, IgG4, and ceruloplasmin, we suggest that increased intraglomerular hydraulic pressure, although enhanced GFR was not demonstrated, may be at work in these mildly hyperglycemic subjects.  (+info)

Hepatic hyperplasia and cancer in rats: alterations in copper metabolism. (7/796)

We previously demonstrated that rats exposed to the peroxisome proliferator (PP) diethylhexylphthalate (DEHP) had reduced serum ceruloplasmin (CP) oxidase activity, which suggests tissue copper deposition. Copper is highly toxic in excess, and results in cellular damage and hepatocellular carcinomas (HCC). This study addresses changes in expression of copper-related genes and metal accumulation in hyperplastic liver and tumors induced by PP. Male rats were fed diets containing DEHP or clofibrate (CLF) for 3-60 days (hyperplasia) and 4-chloro-6-(2,3 xylidino)-2-pyrimidinyl-thio(N-beta-hydroxyethyl) acetamide for 10 months (HCC). During hyperplasia, an immediate and progressive decrease in serum CP activity was observed (P < 0.05), as were reductions in mRNA levels for both CP and Wilson's disease gene (WD gene, a P-type ATPase) (P < 0.05). Tumor-bearing rats had lower serum CP activity (P < 0.05), and CP and WD gene mRNA levels were reduced in tumors (P < 0.05), and in liver surrounding tumors (SL) (P < 0.05). Metallothionein mRNA showed no consistent changes during hyperplasia. Tumors showed a 2.5-fold induction of metallothionein mRNA (P < 0.05), and a 1.2-fold increase in SL. Temporal increases in liver copper content occurred during hyperplasia, with increases of 2-fold (DEHP) and 3.3-fold (CLF) at 60 days (P < 0.05). Copper content was 2.2-fold higher in tumors (P < 0.05) and 1.7-fold higher in SL; iron did not increase and zinc decreased temporally. Thus, copper accumulation and changes in copper-related gene expression may be contributing factors in liver neoplasia in PP-treated rats. Loss of CP results in decreased free radical scavenger capacity and thus may enhance oxidative damage induced by PPs.  (+info)

Hemolytic activity of copper sulfate as influenced by epinephrine and chelating thiols. (8/796)

AIM: To study the effects of epinephrine, homocysteine, and other complexing agents on the cytotoxicity of copper sulfate. METHODS: In vitro suspensions of human red cells incubated with cupric sulfate were used, and hemolysis was determined by extracellular hemoglobin. RESULTS: The hemolytic activity of CuSO4 (0.3 mmol.L-1) was enhanced by the presence of epinephrine and to a lesser extent by homocysteine, whereas D-penicillamine, succimer, and mercaptodextran reduced the copper-induced hemolysis. The latter 3 chelating thiols also reduced the copper-epinephrine-induced hemolysis. The plasma protein ceruloplasmin reduced markedly the copper-epinephrine-induced hemolysis, even upon concentrations < 20% of that of copper. Chromic chloride, as well, acted anti-hemolytically. CONCLUSION: The latter protectors may interact with the production or activity of toxic oxygen, while classical copper chelators sequester cupric ions from interaction with epinephrine or homocysteine.  (+info)

Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat mammary gland tissue from pregnant and lactating animals. Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other extrahepatic tissues. Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus. In virgin female mammary gland the content of ceruloplasmin mRNA was 20% of that in hepatic tissue from these animals and approx. 2-3-fold greater than that found in mammary gland tissue of pregnant or lactating animals. Development studies revealed ceruloplasmin gene expression in male and female mammary gland by only 2 weeks of age, prior to the onset of puberty. Biosynthetic studies indicated that the ceruloplasmin mRNA in ...
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. The rest is accounted for by macroglobulins. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. The molecular weight of human ceruloplasmin is reported to be 151kDa. A cis-regulatory element called the ...
Structure of Ceruloplasmin. CP is involved in oxidative stress and in the safe handling of oxygen in some metabolic pathways of vertebrates and has been shown to be associated with reproduction. Serum levels of ceruloplasmin have been found to increase during normal pregnancy in some species and it is thought that this increase during gestation protects against oxidative stress associated with pregnancy. In dogs, the increase in serum ceruloplasmin has been coupled to the time of embryonic endometrial implantation and placentation. In 2011, Erin Willis from the Memphis Zoo published evidence that Cp activity could be correlated to pregnancy status in giant pandas1. The activity of urinary ceruloplasmin was higher during the pregnant luteal phase compared to the pseudopregnant luteal phase. In all term pregnancies examined, levels of active ceruloplasmin were elevated the first week of pregnancy and remained elevated until 20-24 days prior to parturition.. Decreased concentrations occur during ...
Injection of a 2.0 mg Cd ²⁺ /kg B.W. (I.P. as CdC1 ₂ in .05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine oxidase activity within one hour of injection. Maximal decrease (40%) occurred within six to eight hours, with levels rising slowly over the duration of the experiment (28.5 hours postinjection). Cadmium-109 (36 pCi carrier free ¹⁰⁹ CdC1 ₂ in .05 M HC1, .15 M NaC1) was injected (I.P.) into rats and plasma obtained five hours later. Purification of the ceruloplasmin using DEAE and Sephadex G-200 chromatography revealed significant cadmium-109 in the ceruloplasmin fraction. In vitro binding was not observed. Attempts were made to purify ceruloplasmin utilizing, DEAE, hydroxylapatite and Sephadex G-200 chromatography coupled with ethanol-chloroform precipitation. The product obtained was spectrophotometrically pure and deemed electrophoretically homogeneous, however antibody produced in rabbits to this ...
TY - JOUR. T1 - Copper-related blood indexes in kidney dialysis patients. AU - Emenaker, Nancy J.. AU - DiSilvestro, Robert A.. AU - Nahman, N. Stanley. AU - Percival, Susan. PY - 1996/11. Y1 - 1996/11. N2 - Previous work has suggested that kidney hemodialysis patients could be at risk for either moderate copper deficiency or copper toxicity. The present study examined copper-related blood indexes in subjects undergoing hemodialysis treatments with membranes that are not copper-based, in subjects undergoing chronic ambulatory peritoneal dialysis (CAPD), and in control subjects. Both dialysis groups had low plasma copper and ceruloplasmin activities. This occurred despite high plasma interleukin 6 concentrations, a situation that usually elevates plasma ceruloplasmin and copper values. CAPD and hemodialysis subjects had low ratios of ceruloplasmin activity to immunoreactive protein, and low ratios of plasma copper to ceruloplasmin protein. Both are signs of copper deficiency. In contrast, ...
1. It has been suggested that low levels of serum caeruloplasmin in Wilsons disease result from the failure to switch from a fetal to an adult mode of caeruloplasmin gene expression. To investigate postnatal expression of the caeruloplasmin gene, steady-state levels of caeruloplasmin messenger RNA in adult and neonatal rat liver were measured.. 2. Copper parameters observed in neonatal rats were similar to those seen in Wilsons disease: hepatic copper concentration was significantly elevated (neonatal 164 ± 35 μg/g, adults 50 ± 8 μg/g, P , .001) and serum copper and caeruloplasmin levels were low (neonatal 0.5 ± 0.1 μg/ml, adults 1.3 ± 0.2 μg/ml, P , .001; neonatal 0.20 ± 0.04 arbitrary units, adults 0.69 ± 0.16 arbitrary units, P , .001), respectively.. 3. Caeruloplasmin messenger RNA levels were analysed by Northern and dot blotting using a 12P-labelled caeruloplasmin complementary DNA probe. A caeruloplasmin messenger RNA of approximately 4.4 kilobases was detected in both adult ...
Gentaur molecular products has all kinds of products like :search , Alpha Dia \ Mouse Ceruloplasmin protein control for western blot \ CP16-C for more molecular products just contact us
The LEGENDplex™ Human Acute Phase Panel 1 Mix and Match Beads are individual capture beads for 8 targets including α2-macroglobulin, α1-AGP, Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and Matc
article{6a3b745a-c0d2-4c84-adfb-493281880774, abstract = {Background- The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins.,br/,,br, ,br/,,br, Methods and Results- Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 5064 healthy men aged 28 to 61 years. All-cause mortality, cardiovascular mortality, and incidence of myocardial infarction were monitored over a mean follow-up period of 18.4 years. Low FVC (fourth quartile) was associated with higher protein levels and with increased incidences of myocardial infarction and cardiovascular death. Adjustments for protein levels reduced the age-adjusted relative risks (RRs) for myocardial infarction (from 1.99, 95% CI 1.5 to 2.6, to 1.70, 95% CI 1.3 to 2.2) and cardiovascular death ...
Infobox_gene}} Ceruloplasmin (or caeruloplasmin) is a [[ferroxidase]] [[enzyme]] that in humans is encoded by the CP [[gene]].,ref name=pmid6582496>{{cite journal , vauthors = Takahashi N, Ortel TL, Putnam FW , title = Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule , journal = Proceedings of the National Academy of Sciences of the United States of America , volume = 81 , issue = 2 , pages = 390-4 , date = Jan 1984 , pmid = 6582496 , pmc = 344682 , doi = 10.1073/pnas.81.2.390 }},/ref>,ref name=pmid2873574>{{cite journal , vauthors = Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT , title = Complete cDNA sequence of human preceruloplasmin , journal = Proceedings of the National Academy of Sciences of the United States of America , volume = 83 , issue = 14 , pages = 5086-90 , date = Jul 1986 , pmid = 2873574 , pmc = 323895 , doi = 10.1073/pnas.83.14.5086 }},/ref>,ref name=pmid3474786>{{cite journal , vauthors = Royle ...
ST.LOUIS- The discovery of a gene associated with a rare form of Parkinsons disease provides researchers with a long sought piece to the puzzling pathogenesis of this disease.. A team of researchers at Washington University School of Medicine in St. Louis have characterized a rare disease, aceruloplasminemia, that causes a rare form of Parkinsons. Aceruloplasminemia is caused by a mutation in the ceruloplasmin gene, which is involved in iron transport.. Patients with this gene mutation do not make ceruloplasmin, a protein that removes iron from cells. The iron then accumulates in cells in the brains basal ganglia region and causes neurological problems. These include the tremors and gait abnormalities associated with Parkinsons disease, according to Jonathan D. Gitlin, M.D., associate professor of pediatrics, Washington University School of Medicine.. Neurologists have long hypothesized that Parkinsons disease results from a combination of genetic and environmental factors. The current ...
Methods and Results-Cp was measured at ARIC visit 4 (1996-1998). We studied 9240 individuals without HF or CVD at ARIC visit 4 and followed them for a mean of 10.5 years. Genome-wide association study was performed to identify genetic determinants of Cp levels and evaluate their association with incident HF in ARIC participants. Cp levels (mean±SD) were higher in women versus men (335±79 versus 258±44 mg/L; P,0.0001), women on versus not on hormone-replacement therapy (398±89 versus 291±60 mg/L; P,0.0001), and African Americans versus whites (299±63 versus 293±74 mg/L; P=0.0005). After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). A locus on the ceruloplasmin gene on chromosome 3 was significantly ...
Background and Purpose: Pre-eclampsia is a pregnancy disorder which increases maternal and pre-natal morbidity and mortality. The incidence is about 5% and is influenced by pariety, genetic background, and environmental factors. At present, the sole treatment is termination. It is suitable to use antioxidants for pre-eclampsia prevention. The aim of this ...
This graph shows the total number of publications written about Ceruloplasmin by people in this website by year, and whether Ceruloplasmin was a major or minor topic of these publications ...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie Alzheimers and Parkinsons disease. The linkage between hepcidin (Hepc) and ferroportin-1 (FPN1), the divalent metal transporter 1 (DMT1), and ceruloplasmin (CP) in the brain is unknown. To discern the role of Hepc in regulating the expression of these proteins, we investigated FPN1, DMT1, and CP protein and mRNA expression in the brain after the intracerebroventricular injection of Hepc. Our results show that after Hepc injection, expression of FPN1 mRNA and FPN1 protein was inhibited in the cerebral cortex and hippocampus. Furthermore, we showed a clear change of DMT1 and CP protein and mRNA levels in the brain. The immunohistochemical analysis revealed an increase of DMT1 and a decrease of CP levels. Semi-quantitative analysis using PCR methods showed an increase of DMT1(+IRE) mRNA, and a decrease of DMT1(-IRE) mRNA and CP mRNA levels. Since alterations in iron levels in the brain are ...
Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free radical scavenger. The structural organization of Cp causes its sensitivity to proteolysis and ROS (reactive oxygen species), which can alter some of the important Cp functions. Eluc
Study of impairment in collaboration between ceruloplasmin and transferrin in development of complications in type 2 diabetes mellitus
Ceruloplasmin (též ceruloplazmin) je bílkovinná sloučenina s vlastnostmi enzymu, která je v organizmu důležitá pro transport molekul mědi a pro metabolizmus železa (přeměna iontu Fe2+ na Fe3+). Snížená koncentrace ceruloplasminu je velmi často přítomna u jedinců s Wilsonovou nemocí, není však příčinou jejího vzniku ...
Gentaur molecular products has all kinds of products like :search , Assaypro \ Ceruloplasmin, anti_rat Species Rat Format Biotin_IgG Host Rabbit Polyclonal antibody \ 11931-05021 for more molecular products just contact us
Description: The Serum Copper test is, along with serum ceruloplasmin, is used to test for Wilson disease and more frequently used to monitor nutrition, especially when copper deficiency is indicated ...
Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. The Dunaief lab has found that AMD retinas have iron overload, which can cause oxidative stress. Increased understanding of retinal iron homeostasis may lead to treatments for AMD. To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. A mouse line deficient in the iron transporting ferroxidases ceruloplasmin and hephaestin develops age-dependent retinal iron overload and retinal degeneration with features of AMD (Hahn et al., PNAS, 2004). Recent research in the lab indicates that inflammation promotes cellular iron overload in a vicious cycle leading to cell death. Our current focus is on the mechanisms of retinal iron homeostasis and development of therapeutics to ...
Screening tests Serum glucose, electrolytes, calcium/phosphorus, uric acid, lactate and pyruvate, liver, renal and thyroid function tests, blood gasses Prolactin levels (10 to 20 min after suspected seizure, diagnosis seizure vs. psychogenic nonepileptic seizure) Serum CK ANA, ENA, ANCA, RF, complement, ACE, anti-thyroglobulin and anti-thyroperoxidase antibodies (Hashimoto disease), autoantibody panel (thyroid antimicrosomal, antiparietal), immunoglobulins Serum ceruloplasmin…
Reaktivität: Alle Spezies, Huhn, Rind (Kuh) and more. 90 verschiedene CP ELISA Kits vergleichen. Alle direkt auf antikoerper-online.de bestellbar!
How can I be sure that the patient has Wilson disease? Overview Wilson disease (WD) is an autosomal recessive disorder that results from mutations in the ATP7B gene located on the long arm of chromosome 13. More than 500 mutations have been identified. ATP7B protein is responsible for both hepatic copper incorporation into ceruloplasmin and…. ...
Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ; Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.; J Nutr, 2010 PubMed Europe PMC ...
An Interview with William J. Walsh, PhD This is the sixth article in a series of seven articles.. View Part 1, Part 2, Part 3, Part 4 and Part 5.. JH: What kinds of testing do you recommend for patients?. WW: If patients had every blood and urine test that would provide valuable information, they probably wouldnt have any money left - or any blood - so we have to prioritize. Because six or seven factors are dominant in most cases, we start off with a panel of tests that is relatively inexpensive, maybe only $300 or $400. We have to do additional testing in only about ten percent of the cases. We look for markers of oxidative stress and at the important metals, espe-cially zinc and copper, that impact neurotransmitters. We measure the protein called ceruloplasmin because looking at serum copper and ceruloplasmin jointly reveals a lot about free radicals and oxidative stress. We need to have a marker for methylation, and what we have been using is whole blood histamine. Its imperfect, and ...
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1 ...
Results of previous studies have shown that the VX2 carcinoma in rabbits synthesizes large amounts of prostaglandin E2 (PGE2). PGE2 secreted by the tumor is rap
健康な日本人におけるセルロプラスミンとフェリチンを含む酸化ストレスバイオマーカーの関連 ...
accounting acidic additional aggravate appears applied assoc atrophy beneficial bottom cellular cognitive college contributed control controls correlated correlation correlations cortex dependent derived determine disease downloaded drive early elderly elucidate enhance explaining export expressed fluid fusiform hand healthy hierarchical homeostasis impairment indicated inflammation institute interact involved iron king kingdom latter marker matched measures metabolism metal mild model negatively operates park pathogenesis pathology positively progression protein proteins psychiatry psychology reactive regression regulatory relationship respectively restore seems significantly stage store subjects suggesting supports synergy therapies tracking true variable variation ventricles volume volumes whereas ...
Ordering: You can also order using info[at]zellx.de or FAX at +49(0)731 55211719 Technical Support: Customer satisfaction is very important to us. Please call us at +49(0)731 55211521 or send an email to technical[at]zellx.de with your technical questions. A member of our scientific staff will be glad to assist you. ...
Membrane Protein Involved In Zinc Ion Homeostasis; Member Of The Four-protein IZH Family, Expression Induced By Zinc Deficiency; Deletion Reduces Sensitivity To Elevated Zinc And Shortens Lag Phase, Overexpression Reduces Zap1p Activity
I had my first FET with a normal embryo. My RE said it had an 85% chance of implanting, but it didnt. Im looking for reasons this might have happene
I know I am getting in early but figure may as well as I cant be the only one waiting til October to start our FET. I didnt think Id be back here after we got our BFP in March after our first successful round but unfortunately our DD - page 55
Thirteen healthy adult males, ages 20-40, consuming self selected diets, were given instructions to take one 500 mg tablet of ascorbic acid three times a day with their meals for a period of ten weeks. The effect of this daily supplementation on copper status was investigated. An estimation made from a three day diet record kept by each subject indicated their dietary copper intake to be 1.92 mg per day. Determination of serum ceruloplasmin and serum copper done on the first day of the ascorbic acid supplementation period showed that the subjects fell within accepted ranges of normal. All further determinations of these parameters during the experimental period were compared to initial values so that each subject served as his own control. At week seven the high ascorbic acid intake significantly decreased ceruloplasmin by 26 percent. At the end of the ten week ascorbic acid supplementation period, serum ceruloplasmin activity was significantly lowered by 20 percent. The slight increase over ...
Aceruloplasminemia is a rare autosomal recessive disorder in which iron gradually accumulates in the retina, basal ganglia, and other organs. Iron accumulation in the brain results in neurological problems that generally appear in adulthood and worsen over time. Aceruloplasminemia has been seen worldwide, but its overall prevalence is unknown. Studies in Japan have estimated that approximately 1 in 2 million adults in this population are affected. Aceruloplasminemia belongs to the group of genetic disorders called neurodegeneration with brain iron accumulation (NBIA). Patients with aceruloplasminemia develop a variety of movement problems. They may experience dystonia of the head and neck, resulting in repetitive movements and contortions. Other involuntary movements may also occur, such as tremors, chorea, blepharospasms, and grimacing. Affected individuals may also experience ataxia, the lack of coordination of muscle movements. Some develop psychiatric problems and midlife dementia. The type ...
Periodontitis, is an infectious ailment of multifactorial origin, that brings about destruction of bone and surrounding tissues. There are various oral pathogens that may be responsible for the destruction. The host encounters these microbial invasions and their products by the production and release of inflammatory mediators from the cells within the body. Glutathione-S-transferase (GST) are a group of enzymes that utilize glutathione in conditions resulting in oxidative stress. These enzymes play a key role in the detoxifycation of such substance. It aids in preventing damage to important cellular components caused by release of free reactive oxygen species. Ceruloplasmin is a ferroxidase enzyme. It plays a role as an anti-inflammatory agent, by its ability to scavenge free radicals within the body. The present study was targeted at evaluating the levels of Glutathione-S-Transferase (GST) and Ceruloplasmin as diagnostic markers for patients with chronic periodontitis in gingival crevicular fluid (GCF)
Looking for Copper oxidase? Find out information about Copper oxidase. The copper-binding serum protein in human blood. a copper-containing protein of the α2-globulin fraction of blood plasma. It was first discovered and... Explanation of Copper oxidase
In this report, we present novel evidence linking FLP to high-affinity Fe transport and propose that FLP is a ferroxidase, functioning in the reoxidation of Fe2+ before its uptake into the cell. Initial evidence in support of this hypothesis comes from the deduced FLP amino acid sequence. FLP contains two multicopper oxidase I and one multicopper oxidase signature II motifs. In addition, the amino acid sequence of FLP shows the highest homology to multicopper oxidases in mammals (HEPH and ceruloplasmin) and yeast (FET3). These proteins are ferroxidases that are themselves involved in high-affinity Fe assimilation (Stearman et al., 1996;Askwith and Kaplan, 1998; Mukhopadhyay et al., 1998; Attieh et al., 1999; Vulpe et al., 1999). The involvement of FLP in Fe homeostasis is evident from the regulation of its synthesis. Both the transcription of the FLP gene and synthesis of FLP are greatly increased in Fe-deficient cells and reversed after resupply of Fe. Although we have not demonstrated the ...
Ferritins are ubiquitous and can be found in practically all organisms that utilize Fe. They are composed of 24 subunits forming a hollow sphere with an inner cavity of ~80 A in diameter. The main function of ferritin is to oxidize the cytotoxic Fe(2+) ions and store the oxidized Fe in the inner cavity. It has been established that the initial step of rapid oxidation of Fe(2+) (ferroxidation) by H-type ferritins, found in vertebrates, occurs at a diiron binding center, termed the ferroxidase center. In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C). In an effort to obtain further evidence supporting the presence of a trinuclear Fe binding center in bacterial ferritins and to gain information on the states of the iron bound to the trinuclear ...
Methods and Results- Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future AAA were 0.4%, 1.0%, 1.3%, and 2.3% for men with none, one, two, and ,=3 ISPs, respectively, in the top quartile (trend: P,0.0001). The corresponding odds ratios were 1.00 (reference), 1.9 (95% CI: 0.8 to 4.5), 2.2 (0.9 to 5.5), and 3.2 (1.4 to 7.2), respectively, adjusted for age, screening year, smoking, cholesterol, triglycerides, systolic blood pressure and physical inactivity (trend: P=0.004 ...
Levels of serum copper in 34 patients with adult non-Hodgkins lymphoma at different phases of the disease have been studied. All of the patients were evaluated with complete blood counts, sedimentation rate, gallium scintigraphy, liver and bone marrow biopsies, lymph node biopsy, and laparoscopy. The level of serum copper was significantly elevated in non-responding or relapsing patients (mean 191.06 micrograms/dl), and correlated with the estimated tumor burden. Serum copper levels within normal range were found in patients in complete remission (mean 114.76 micrograms/dl). Age- and sex-matched normal controls also showed serum copper levels within normal range (mean 112.81 micrograms/dl). It is proposed that serial measurements of serum copper level may be of use in: (1) monitoring the remission status of patients with non-Hodgkins lymphoma, (2) detecting early relapse of non-Hodgkins lymphoma, and (3) contrary to previous reports by Hrgovcic et al., the level of serum copper seems to be ...
CuD subjects In order to be enrolled into the CuD Arm, subjects who have had RYGB surgery will be recruited and screened for eligibility (inclusion and exclusion criteria below). Subjects whose plasma copper concentrations are in the deficient range (less than 80 μg/dL for women and less than 70 µg/dL for men, and/or ceruloplasmin activity below 62 units/L-1) following 4 weeks of supplementation with the RDA for copper will be eligible. Such supplementation is the routine standard of care with all patients undergoing RYGB surgery. This process aims to exclude patients who were only marginally copper deficient and not in need of sustained copper therapy. Subjects will be notified about their copper status by a study physician. They will be contacted by the study team, and their willingness to participate in the study will be determined.. Inclusion criteria: 1) Patient has a history of RYGB weight loss surgery; 2) subject has a plasma copper level which is less than 80 μg/dL for women andl less ...
研究論文業績医学雑誌総説KonoS:Aceruloplasminemia,Curr Drug Targets, 13(9):1190-9, 2012.KonoS.Aceruloplasminemia: an update.Int Rev Neurobiol. 2013;11...
References 1. Cauza E, Maier-Dobersberger T, Polli C, Kaserer K, Kramer L, Ferenci P. Screening for Wilsons disease in patients with liver diseases by serum ceruloplasmin. Journal of hepatology. 1997;27:358-62. 2. Medici V, Rossaro L, Sturniolo GC. Wilson disease--a practical approach to diagnosis, treatment and follow-up. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2007;39:601-9. 3. Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology (Baltimore, Md). 2008;47:2089-111. 4. Stremmel W, Meyerrose KW, Niederau C, Hefter H, Kreuzpaintner G, Strohmeyer G. Wilson disease: clinical presentation, treatment, and survival. Annals of internal medicine. 1991;115:720-6. 5. Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annual review of nutrition. 2002;22:439-58. 6. Scott J, Gollan JL, Samourian S, Sherlock S. Wilsons disease, presenting as chronic active ...
The relation between elevated ISPs and an increased incidence of acute coronary events is now well established. Whether the fatality of the events is related to the previous exposure to a low-grade inflammation has been unclear. In the entire cohort, the relative risks were higher for CHD deaths than for nonfatal MI. Among men who subsequently had acute coronary events, the number of elevated ISPs at baseline showed significant associations with the proportions of fatal outcomes (first day or within 28 days). The individual ISPs showed nonsignificant differences between CHD deaths and nonfatal MI. However, in accordance with many previous studies, the prognostic information increased substantially if all 5 ISPs were used.2,11,12,15 The results show that men who have been exposed to a low-grade inflammation many years earlier have higher fatality in future acute coronary events, with a higher proportion of CHD deaths and less nonfatal MI. If this finding can be replicated in other ...
Wilsons Disease Treatment of Alternative Wilsons Disease Alternative Neuro Acupuncture Treatment and Wilsons Disease Herbal Herbs Alternative Medicine Treatment on Wilsons Disease Treatment Medical Center Wilsons Disease Remedies
In this report, we have determined serum transferrin (TF) and ceruloplasmin (CP) in patients with liver and renal diseases. Results indicate that TF in all hepatitis groups are significantly lower than that in the nor- mal group. The TF level in patients with abnormal GPT and positive HBsAg are significantly lower than that in normal persons. Therefore, the TF level may be referred to as an index for the hepatitis prognosis. The TF level in nephropathy patients are also lower than that in normal persons. Contents of CP in each group are not similar, for example in patients with hepatic carcinous (52.44±8.73mg%) are significantly higher than that in the normal group (46.75±7.92mg%), but there is no significant difference between hepatic B and normal group. Contents of CP in hepatolenticular degeneration are significantly lower than that in normal group (P 0.001). Therefore, measurement of CP which provides an available objective index is helpful to distingulsh the hepatocirrhosis
LifeLabs is introducing new assay methods for therapeutic drug monitoring (TDM) tests, and for ASOT (antistreptolysin O antibodies / titer), ceruloplasmin and haptoglobin testing. For some tests this means a change in the assay platform. A major benefit from these changes is the standardization of the assay methods and reporting across all LifeLabs laboratory sites.. Overall, there will be no significant change to reported results. However we have taken this opportunity to update some of the therapeutic ranges, in accordance with current guidelines, and where appropriate, to update analyte reference intervals.. The change will take place on December 11, 2017. At that time, a message will appear on the affected lab reports indicating the details of the change for each test. Please refer to the lab report for analyte specific messages,therapeutic ranges, orreference intervals.. The following tests are affected:. ...
Copper and Human Health To say Copper is an essential trace mineral barely does justice when one considers the wide range of vital human bodily functions dependent upon this mighty mineral. To begin with, copper is a major component of hemoglobin, the protein resposible for oxygen transport in blood cells. Copper, along with vitimin C, forms elastin, a protein required to keep skin, blood vessels, and lungs supple and elastic. As an antioxidant, copper plays a strong dual role. First as a central component of both the superoxide dismutase molecule, which protects us from cellular free-radical damage. Secondly, copper helps form the protein ceruloplasmin, which protects us against free-radical damage caused by iron. Copper is also required by the central nervous system as a component in the production of noradrenaline, the brains version of adrenaline and the neurotransmitter that keeps us alert. Copper is also involved in the production of prostaglandins, hormonelike chemicals that regulate ...
Copper, a strong prooxidant, may play a role in atherogenesis. The author examined the association between serum copper concentration and mortality from coronary heart disease using data from the Second National Health and Nutrition Examination Survey (1976-1992). Serum copper concentration was dete …
Further Observations generic cialis available on the Diseases which affect the Synovial Membranes of Joints. Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. Mechanism for hormone-induced alterations in serum ceruloplasmin. Hence, global gene-expression profiling on inguinal lymph nodes was performed 10 days after the induction of pristane-induced arthritis (PIA) and phytol administration.. According to the method used, no generic cialis available significant beneficial effect could be demonstrated in either experimental model. The dichotomous response pattern and positivity offset differed between words and pictures in patients with alcohol dependence. In closed glass containers exposed to about I Mrad of gamma radiation, ozone concentrations up to 18 parts per million (by volume) were recorded. Effect of ...
DESIGN: The test was performed on juvenile fish, which was exposed to Spartakus (concentrations of prochloraz: 0.05; 0.15 and 0.38 mg.L-1) for 28 days. Haematological indices were assessed using unified methods of haematological examination in fish. Plasma biochemical indices were determined by biochemical analyzer. Concentration of total cytochrome P450 (CYP), glutathione (GSH) content and glutathione-S-transferase (GST) activity were determined spectrophotometrically in hepatopancreas. Activity of liver ethoxyresorufin-O-deethylase (EROD) activity was measured spectrofluorimetrically. Ferric reducing ability of plasma (FRAP) and ceruloplasmin activity were assessed spectrophotometrically. Histological changes in samples of hepatopancreas, skin, gills, spleen, head kidney and caudal kidney were examined by light microscopy ...
Around this time of year, a lot of us are relying heavily on vitamin C and zinc supplements to mediate the effects of a bad cold or flu which can be bacterial or viral in nature. Natural systems in the body, such as the iron withholding defense system (IWDS), are activated to protect us from these pathogens when they invade. Where the IWDS withholds iron, other metals such as copper and zinc and the transport proteins transferrin and ceruloplasmin are present to maintain iron balance.. Copper and zinc - when behaving properly - are boosters of our immune system, powerful antioxidants, and defend us against the overproduction of free radicals generated by too much iron. Transferrin and ceruloplasmin share in the task of keeping us healthy by binding and transporting iron and copper. Transferrin, when too heavily saturated with iron, makes us more susceptible to infection. When too low, ceruloplasmin allows iron and copper to accumulate, resulting in a free radical production bonanza.. Even though ...
In episode 33, we continue the series on assessing and managing nutritional status. This time we talk about copper. Copper deficiency can cause anemia that is very difficult to tell apart from iron-deficiency anemia, osteoporosis, histamine intolerance, high cholesterol, and a variety of mental effects resulting from neurotransmitter imbalances. Serum copper and ceruloplasmin are excellent tools for assessing nutritional status, but are confounded by inflammation, birth control, menopausal status, and hormone replacement therapy, making it necessary to look at the diet, lifestyle, digestive problems, and other factors that make copper deficiency plausible.  I discuss how to protect yourself from the small risk of copper in your drinking water, and why I think many claims about excess copper outside the context of frank toxicity are misleading. Everything converges on the practical questions of what to do in these situations. You can find the show notes to this episode at chrismasterjohnphd.com/33.
Definition of Copper deficiency in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Copper deficiency? Meaning of Copper deficiency as a finance term. What does Copper deficiency mean in finance?
Definition of Copper deficiency in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Copper deficiency? Meaning of Copper deficiency as a legal term. What does Copper deficiency mean in law?
Effect of copper deficiency on prenatal development and pregnancy outcome.: Copper deficiency during embryonic and fetal development can result in numerous gros
Copper is an essential micronutrient for most organisms, especially in respiring eukaryotes, due to its being a cofactor in electron transfer proteins and in enzymes that catalyze redox reactions or oxygen chemistry, such as cytochrome oxidase, ferroxidases, and Cu/Zn superoxide dismutases. The availability of copper in the environment or in the nutrient source may vary widely, however, and copper deficiency is a challenge that many organisms encounter, a challenge they have met through the evolution of sophisticated adaptive mechanisms. At the same time, free copper ions have the potential to participate in Fenton chemistry resulting in the production of reactive oxygen species. Copper assimilation must therefore be tightly regulated so as to meet but not exceed cellular requirements (reviewed in Eide, 1998; Puig and Thiele, 2002; Winge, 2002; Merchant et al., 2006; Pilon et al., 2006),. Genetic and biochemical studies in a number of model organisms have established the existence in eukaryotes ...
Copper is an essential trace element. It is required for ferro-oxidase activity which is an essential stage for incorporation of iron into haem. Copper is absorbed in the intestines and then transported to the liver, where it is stored or used in the production of a variety of enzymes. Caeruloplasmin is a copper-containing enzyme that plays a role in the bodys iron metabolism. In the blood, 95 % is bound to caeruloplasmin and 5 % is free. It is used in conjunction with serum copper assay to help diagnose Wilsons disease and evaluate copper metabolism.. ...
Normally food copper is metabolized by the liver and channeled into safe pathways such as being incorporated in to ceruloplasmin. [...] When we administer inorganic copper orally labeled with 64Cu, we see a fraction of the label appear in the blood in 1-2 hours, too soon to be processed by the liver. [...] We believe this fraction of 64Cu-labeled inorganic copper is bypassing the liver, is therefore not incorporated safely into ceruloplasmin, contributes directly to the nonceruloplasmin free copper pool, and represents what is happening to at least a portion of the inorganic copper ingested in drinking water or copper supplements.[32] ...
We found an age-related increase of iron in the white matter of controls as well as in patients with short disease duration. In chronic MS, however, there was a significant decrease of iron in the normal-appearing white matter (NAWM) corresponding with disease duration, when corrected for age. This decrease of iron in oligodendrocytes and myelin was associated with an upregulation of iron-exporting ferroxidases. In active MS lesions, iron was apparently released from dying oligodendrocytes, resulting in extracellular accumulation of iron and uptake into microglia and macrophages. Iron-containing microglia showed signs of cell degeneration. At lesion edges and within centers of lesions, iron accumulated in astrocytes and axons ...
Wilsons disease (-) ceruloplasmin does not rule out Keyser-Fleischer rings absent in 50% AST & ALT |1500 Normal or low alk phos for age (cofactor Zn displaced by Cu) AST:ALT |2.2 AlkPhos : TotBili |4
簡介 Wilson disease是一種銅代謝異常的體染色體隱性疾病,常會造成肝臟的受損和神經精神病變。 銅的代謝 正常人一天大約會攝入1-2mg的銅,其中約10%會被身體吸收 被吸收的銅,會和albumin結合,送到肝臟代謝 到肝臟之後,WDP (ATP7B)蛋白能夠協助銅的代謝 →能協助銅和運銅蛋白結合,以ceruloplasmin的形式進入血中 →也可協助銅經由膽汁排泄 病生理機轉 為體染色體隱性疾病,因為ATP7B基因的突變,導致銅代謝異常 因為銅無法被排入膽汁→導致膽汁的...
Olatunbosun, D. A., Bolodeoku, J. O., Cole, T. O. & Adadevoh, B. K. (‎1976)‎. Relationship of serum copper and zinc to human hypertension in Nigerians*. Bulletin of the World Health Organization, 53 (‎1)‎, 134 - 135. https://apps.who.int/iris/handle/10665/260875 ...
Patients with moderate to high risk primary breast cancer (Stage II with more than 4 lymph nodes involved with cancer) III or Stage IV (without evidence
We tried to establish possible correlations between clinical data and MRI in a group of patients with Wilsons disease. Eleven patients (6 male, 5 female), aged between 11 and 50 years old, with a duration of illness from 5 months to 32 years, were submitted to MRI on a 1.5 T System. Three patients …
Our physicians collaborate closely to diagnose and treat Wilsons disease. Treatment depends on the organs involved and overall health of the patient.
WILSONS DISEASE answers are found in the Harrisons Manual of Medicine powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Serum levels rise for other proteins, cialis 5mg wirkungseintritt such as ceruloplasmin, complement proteins, haptoglobin, fibrinogen, and C-reactive
Topley & Wilsons microbiology and microbial infections , Topley & Wilsons microbiology and microbial infections , کتابخانه دیجیتال دانشگاه علوم پزشکی تهران
University of Navarra CIMA scientists have used gene therapy to develop a vector which corrects the origin and reverses the symptoms of this rare hepatic disease. The research is the cover article of the Journal of Hepatology, the most prestigious scientific journal in its field. See the full article attached.
Jake Guentzel scored the winner for Pittsburgh, but not before Tom Wilsons goal in the final seconds of regulation forced overtime.
Just thinking out loud... Question: How valuable is it knowing SHBG numbers mid-cycle? seems it would be more helpful to know between cycles, right?
adeelarshad82 writes For a second year in a row PCMag partnered with Speedtest to find out the fastest ISPs in the U.S. The results were a product of 110,000 tests ran between January 1, 2012 and September 19, 2012. Collecting data for both download and upload speeds for each test, Speednet was abl...
17 January 2018 - 10:36 PM) Closest I got to free was 30% off warpath, which just about lined him up to the canadian price had he ever shown up around me. The pile of loot saved me a pile, but it was still pricy.. ...
Page contains details about few-layer SnS2 FET . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
last year when I had my FET I was supremely confident it would work (tw it did, but I mced) PLUS I had been testing and poasing and knew by then I was...
(Quote) last year when I had my FET I was supremely confident it would work (tw it did, but I mced) PLUS I had been testing and poasing and knew by then I was...
There is no totally reliable test for Wilson's disease, but levels of ceruloplasmin and copper in the blood, as well of the ... Copper accumulates in the liver tissue; ceruloplasmin is still secreted, but in a form that lacks copper (termed ... The liver also releases copper into the bloodstream that is not bound to ceruloplasmin. This free copper precipitates ... non-ceruloplasmin bound) copper has a direct effect on either oxidation of hemoglobin, inhibition of energy-supplying enzymes ...
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH (1970). "Physical and chemical studies on ceruloplasmin. 8. ... Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin". J. Biol. Chem. 245 (4): 759-66. PMID 4313609. Paulson JC, ...
Ceruloplasmin also oxidizes iron from its ferrous state to the ferric form that is required for iron binding. Impairment in ... Low levels of copper and ceruloplasmin in the serum are consistent with the diagnosis as is a low 24 hour urine copper level. ... Another iron transporting enzyme is ceruloplasmin. This enzyme is required to mobilize iron from the reticuloendothelial cell ... ceruloplasmin, Cu/Zn superoxide dismutase, and in amine oxidases. These enzyme catalyze reactions for oxidative phosphorylation ...
Ceruloplasmin. 1.17: Acting on CH or CH2 groups. *Xanthine oxidase. *Ribonucleotide reductase ...
... s, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their activity is regulated by factors that control their ability to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to the larger group of enzymes called GTPases.. There are two classes of G proteins. The first function as monomeric small GTPases, while the second function as heterotrimeric G protein complexes. The latter class of complexes is made up of alpha (α), beta (β) and gamma (γ) subunits.[1] In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex.. G proteins located within the cell are activated by G protein-coupled receptors (GPCRs) that span the cell ...
Ceruloplasmin. 1.17: Acting on CH or CH2 groups. *Xanthine oxidase. *Ribonucleotide reductase ...
Main article: Ceruloplasmin. Ceruloplasmin is the major copper-carrying protein in the blood. Ceruloplasmin exhibits oxidase ...
α2 - haptoglobin, α2-macroglobulin, α2-antiplasmin, ceruloplasmin. The beta (β) band - transferrin, LDL, complement The gamma ( ...
The effects of estradiol undecylate on serum lipids and ceruloplasmin levels have been studied as well. A phase III clinical ... Götz, H.; Ehrmeier, H. (1971). "Oestrogene und Coeruloplasminspiegel" [Estrogens and ceruloplasmin levels]. Archiv für ...
... s include: Ceruloplasmin EC 1.16.3.1 (ferroxidase), a 6-domain enzyme found in the serum of mammals and ... Messerschmidt A, Huber R (January 1990). "The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and ...
alpha-2 (Ceruloplasmin). *Retinol binding protein. other:. *alpha-1 (Orosomucoid). *alpha-2 (alpha-2-Macroglobulin, Haptoglobin ...
Green color can be due to ceruloplasmin or sulfhemoglobin. Latter may form due to medicines that are able to form sulfonamides ...
Wolf T. L.; Kotun J.; Meador-Woodruff J. H. (2006). "Plasma copper, iron, ceruloplasmin and ferroxidase activity in ...
Ceruloplasmin is also an acute-phase protein produced by monocytes, and its plasma concentration can double during multiple ... Mazumder B, Sampath P, Fox PL (2005). "Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated ... Mazumder B, Sampath P, Fox PL (2006). "Translational control of ceruloplasmin gene expression: beyond the IRE". Biol Res. 39 (1 ... UTR of the ceruloplasmin (Cp) mRNA. The GAIT element forms a stem-loop secondary structure. The GAIT element is involved in ...
While deficiency in hephaestin or ceruloplasmin alone do not seem to cause iron buildup in the retina, studies done on murine ... Human iron metabolism Ceruloplasmin GRCh38: Ensembl release 89: ENSG00000089472 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... While the structure and kinetic activity of ceruloplasmin have been studied extensively, hephaestin has yet to be investigated ... While hephaestin shares 50% amino acid sequence identity with its serum homologue ceruloplasmin, the hephaestin protein ...
transferrin - a blood plasma protein for iron ion delivery Testicular ceruloplasmin - a ceruloplasmin-like protein which is ... Skinner MK, Griswold MD (June 1983). "Sertoli cells synthesize and secrete a ceruloplasmin-like protein". Biology of ... immunologically similar to serum ceruloplasmin The occluding junctions of Sertoli cells form the blood-testis barrier, a ...
... which involves the protein ceruloplasmin, carrying the majority of copper in blood. Ceruloplasmin also carries the copper that ... Severe deficiency can be found by testing for low plasma or serum copper levels, low ceruloplasmin, and low red blood cell ... S.S. Percival; Harris, E.D. (1 January 1990). "Copper transport from ceruloplasmin: Characterization of the cellular uptake ... Frieden, E.; Hsieh, H.S. (1976). Ceruloplasmin: The copper transport protein with essential oxidase activity. Advances in ...
Ceruloplasmin is an acute phase protein synthesized in the liver. It is the carrier of the copper ion. Its levels is increased ... In Wilson disease, the ceruloplasmin level is depressed which lead to copper accumulation in body tissues. AFP is significantly ...
Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol ... Ceruloplasmin FTH1 - Ferritin heavy chain FTMT - Ferritin, mitochondrial HEPH - Hephaestin Cox JC, Boxer DH (1986). "The role ...
The α2 region is mostly haptoglobin, α2-macroglobulin, α2-antiplasmin, and ceruloplasmin. The β band consists of transferrin, ...
The majority of blood copper (or serum copper) is bound to ceruloplasmin. The proportion of ceruloplasmin-bound copper can ... ATP7B directs copper to plasma ceruloplasmin or to biliary excretion in concert with a newly discovered chaperone, Murr1, the ... Most of the copper (70 - 95%) excreted by the liver is incorporated into ceruloplasmin, the main copper carrier in blood. ... Copper is transported to extra-hepatic tissues by ceruloplasmin, albumin and amino acids, or excreted into the bile. By ...
Ceruloplasmin helps move iron from the organs and tissues of the body and prepares it for incorporation into a molecule called ... When ceruloplasmin is unavailable, transport of iron out of the body's tissues is impaired. The resulting iron accumulation ... The CP gene mutation results in the production of ceruloplasmin protein that is unstable or nonfunctional by altering the open ... Diagnosis of this disorder depends on blood tests demonstrating the absence of serum ceruloplasmin, combined with low serum ...
"Considerations about the possible function of ceruloplasmin in influenza and parainfluenza virus infection". www. ...
Sztriha L, Salgó L (April 1985). "[Changes in the blood levels of ceruloplasmin and zinc in children treated with ...
"Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular ...
Special reference to metallothionein and ceruloplasmin". Physiological Reviews. 65 (2): 238-309. doi:10.1152/physrev.1985.65. ...
... ceruloplasmin, serum amyloid A and haptoglobin. Others give negative feedback on the inflammatory response, e.g. serpins. Alpha ...
ClC-4 promotes copper incorporation into ceruloplasmin". Gastroenterology. 126 (4): 1157-66. doi:10.1053/j.gastro.2004.01.015. ...
... ceruloplasmin, transferrin, complement, and glycoproteins. Hepatocytes manufacture their own structural proteins and ...
The ceruloplasmin test measures the level of the copper-containing protein ceruloplasmin in the blood. ... Ceruloplasmin is made in the liver. Ceruloplasmin stores and transports copper in the blood to parts of the body that need it. ... The ceruloplasmin test measures the level of the copper-containing protein ceruloplasmin in the blood. ... Ceruloplasmin (CP) - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO ...
Ceruloplasmin is an α2-globulin containing copper. About 70% or more of total serum copper is associated with ceruloplasmin, 7 ... Ceruloplasmin is high in a variety of neoplastic and inflammatory states, since it behaves as an acute phase reactant, although ... Ceruloplasmin is low in Menkes kinky hair syndrome (In Menkes syndrome the defect is secondary to poor absorption and ... A normal ceruloplasmin does not rule out Wilsons disease. Serum copper should be measured in addition. ...
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major ... Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin ... Lower-than-normal ceruloplasmin levels may indicate the following: Wilson disease (a rare [UK incidence 2/100,000] copper ... Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) ...
Meier, H. Ceruloplasmin variants in mouse serum. Naturwissenschaften 58, 456-457 (1971). https://doi.org/10.1007/BF00624624 ...
Rabbit polyclonal Ceruloplasmin antibody. Validated in WB, IHC, ICC/IF and tested in Rat, Human. Cited in 1 publication(s). ... Anti-Ceruloplasmin antibody (ab110449) at 1 µg/ml + Native Human Ceruloplasmin protein (ab77930) at 0.01 µg. Secondary. Goat ... Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver ... All lanes : Anti-Ceruloplasmin antibody (ab110449) at 1 µg/ml. Lane 1 : Human Plasma Total Protein Lysate Lane 2 : Human liver ...
Ceruloplasmin is a protein that stores and carries copper to your bloodstream. If the test shows too much or too little copper ... This test measures the amount of ceruloplasmin in your blood. ... Other names: CP, ceruloplasmin blood test, ceruloplasmin, serum ... What is a ceruloplasmin test?. This test measures the amount of ceruloplasmin in your blood. Ceruloplasmin is a protein that is ... Why do I need a ceruloplasmin test?. Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson ...
CeruloplasminImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href ... tr,G3UXD2,G3UXD2_MOUSE Ceruloplasmin (Fragment) OS=Mus musculus OX=10090 GN=Cp PE=4 SV=1 ...
Ceruloplasmin test. GENERAL. Copper is transported through the body by means of a protein called ceruloplasmin. The ... Up to six atoms of copper can be bound to each molecule of ceruloplasmin. Low values of ceruloplasmin are found in Wilsons ... High values of ceruloplasmin are found in pregnancy, infections, inflammation, tissue necrosis, trauma, and with estrogen or ... Copper that is not bound to ceruloplasmin for transport is considered more toxic than copper that is bound. ...
References for Abcams Natural Human Ceruloplasmin protein (ab77930). Please let us know if you have used this product in your ...
... products and learn more about Ceruloplasmin Mouse, Unlabeled, Clone: 8, BD 50µg; Unlabeled:Life 50µg; Unlabeled. ... Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. CP contains six copper ...
The ceruloplasmin is then released into blood plasma. Ceruloplasmin carries copper around your body to the tissues that need it ... Ceruloplasmin stores and carries the mineral copper around your body. Ceruloplasmin carries 65% to 90% of the copper found in ... Ceruloplasmin (Blood). Does this test have other names?. CP What is this test?. This test is used to measure how much of a ... Low ceruloplasmin might also mean Menkes disease. This is a genetic disorder that makes it hard for your body to absorb copper ...
Ceruloplasmin (Science: biochemistry) a blue copper containing dehydrogenase protein (135 kD) found in serum (200-500_g/ml) ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Ceruloplasmin&oldid=33512" ...
Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD. ... i,Objectives.,/i, To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is ... i,Methods.,/i, The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an ... Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (,75th percentile) ...
Serum Ceruloplasmin. Serum ceruloplasmin levels are low in newborns and gradually rise within the first 2 years of life. ... Ceruloplasmin levels may also be decreased in 10-20% of Wilson Disease gene heterozygotes, who do not develop Wilson disease ... The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or ... Falsely low ceruloplasmin levels may be observed in any protein deficiency state, including nephrotic syndrome, malabsorption, ...
Mouse Monoclonal Antibody Shop Ceruloplasmin Mouse, Unlabeled, Clone: 8, BD at Fishersci.com ... Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. CP contains six copper ...
Ceruloplasmin-ferroportin system of iron traffic in vertebrates.. Musci G1, Polticelli F1, Bonaccorsi di Patti MC1. ... Structure of human ceruloplasmin. Overall structure of the protein (PDB 1KCW) in two orientations (A: Side view and B: Bottom ... Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for ... Scheme of the role of ceruloplasmin and hepcidin in the degradation of ferroportin. A: In the presence of Cp, Fpn is stable and ...
... Bezeichnung:. Ceruloplasmin (Ferroxidase) ELISA Kits (CP). Auf www.antikoerper- ... Am meisten referenzierte Ceruloplasmin (Ferroxidase) ELISA Kits. Show all Ceruloplasmin (Ferroxidase) (CP) ELISA Kits with ... Human Ceruloplasmin (Ferroxidase) (CP) Interaktionspartner * Mechanistically, ceruloplasmin could specifically interact with ... Weitere ELISA Kits für Ceruloplasmin (Ferroxidase) Interaktionspartner. Mouse (Murine) Ceruloplasmin (Ferroxidase) (CP) ...
Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe,sup>2+,/sup> ( ... Function == Ceruloplasmin is an [[enzyme]] ({{EC number,1.16.3.1}}) synthesized in the liver containing 6 atoms of [[copper]] ... Mutations in the ceruloplasmin gene (CP), which are very rare, can lead to the genetic disease [[aceruloplasminemia]], ... Infobox_gene}} Ceruloplasmin (or caeruloplasmin) is a [[ferroxidase]] [[enzyme]] that in humans is encoded by the ...
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.. Vulpe CD1, Kuo ... We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and ...
To better understand the role of ceruloplasmin in iron homeostasis in the CNS, we generated a ceruloplasmin gene-deficient (Cp ... Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury. Bharatkumar N. Patel, Robert J. Dunn, Suh ... 1993) Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimers disease. Neurosci Lett 159:88-90. ... 3 C,D) and histological evidence of neurodegeneration in the inner nuclear layer of the retina (Fig.4 A-D). Ceruloplasmin mRNA ...
... ceruloplasmin (CP) concentration, CP oxidative activity and CP-specific oxidative activity in serum and superoxide dismutase ( ... Ceruloplasmin and superoxide dismutase (SOD1) in heterozygotes for Wilson disease: A case control study Gudlaug Tórsdóttir1,2, ... Ceruloplasmin and superoxide dismutase (SOD1) in heterozygotes for Wilson disease: A case control study. ... ceruloplasmin (CP) concentration, CP oxidative activity and CP-specific oxidative activity in serum and superoxide dismutase ( ...
Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free ... Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic V. R. Samygina, A. V. Sokolov, G. Bourenkov, T. R. ... Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free ... Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic ...
Compare and order Ceruloplasmin (Ferroxidase) ELISA Kits. View citations, images, detection ranges, sensitivity, prices and ... More product categories related to Ceruloplasmin (Ferroxidase) ELISA Kit * 118 anti-Ceruloplasmin (Ferroxidase) Primary ... Images for product: Ceruloplasmin (Ferroxidase) (CP) ELISA Kit The standard curve is for the purpose of illustration only and ... Images for product: Ceruloplasmin (Ferroxidase) (CP) ELISA Kit The standard curve is for the purpose of illustration only and ...
Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and ... CP, Feroxidase, Ceruloplasmin (Feroxidase) Ave. Rating Submit a Review Product Citations publications ... Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and ...
We measured copper, iron, ceruloplasmin (Cp) concentration and activity, transferrin (Tf), ferroxidase activity, and ferritin, ...
... and the same modification was directly identified in these samples on ceruloplasmin. These results indicate that ceruloplasmin ... 2006) Ceruloplasmin and superoxide dismutase (SOD1) in Parkinsons disease: a follow-up study. J Neurol Sci 241:53-58. ... 2002) Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci 22:6578-6586. ... Ceruloplasmin shows differing isoform patterns in PD. Cp expression was analyzed by SDS-PAGE and WB on CSF proteins. ...
The largest contributor to copper in the plasma is ceruloplasmin, which accounts for 40-70 percent. Apart from ceruloplasmin ... Apart from ceruloplasmin and albumin, most of these components have not been studied extensively, and even for ceruloplasmin ... Ceruloplasmin and other copper binding components of blood plasma and their functions: an update M. C. Linder, Metallomics, ... Ceruloplasmin and other copper binding components of blood plasma and their functions: an update ...
AimsThis study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in ...
Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat ... Tissue-specific ceruloplasmin gene expression in the mammary gland. J L Jaeger, N Shimizu, J D Gitlin ... Tissue-specific ceruloplasmin gene expression in the mammary gland Message Subject (Your Name) has forwarded a page to you from ... Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other ...
Ceruloplasmin. Ceruloplasmin (též ceruloplazmin) je bílkovinná sloučenina s vlastnostmi enzymu, která je v organizmu důležitá ...
  • If a patient is asymptomatic, exhibits isolated liver disease, and lacks corneal rings, the coexistence of a hepatic copper concentration of more than 250 mg/g of dry weight and a low serum ceruloplasmin level is sufficient to establish a diagnosis. (medscape.com)
  • The relationship between serum ceruloplasmin level and cancer incidence was investigated in a case-control study nested within a longitudinal study of 39,268 Finns participating in the Social Insurance Institution's Mobile Clinic Health Examination Survey carried out in 1968-1972. (ox.ac.uk)
  • The overall incidence of cancer was positively associated with serum ceruloplasmin level. (ox.ac.uk)
  • Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. (wikipedia.org)
  • Ceruloplasmin is made in the liver. (medlineplus.gov)
  • hence, ceruloplasmin is used in evaluation of chronic active hepatitis, cirrhosis, and other liver disease. (labcorp.com)
  • Laboratory parameters of Wilson's disease include decreased serum ceruloplasmin, decreased serum copper concentration, increased 24-hour urine copper excretion, increased liver copper concentration, and abnormal liver function studies. (labcorp.com)
  • Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. (abcam.com)
  • Your liver normally takes copper from your bloodstream and puts it into ceruloplasmin proteins. (ahealthyme.com)
  • The ferroxidase ceruloplasmin (Cp), which is produced by the liver and secreted into the plasma, also plays an important role in the movement of iron. (jneurosci.org)
  • Biosynthetic studies indicated that the ceruloplasmin mRNA in mammary gland tissue was translated into a 132 kDa protein qualitatively similar to that synthesized in liver. (biochemj.org)
  • Ceruloplasmin deficiency - Lack of the protein ceruloplasmin from the blood and accumulation of iron in the pancreas, liver and brain, causing diabetes and progressive nervous system degeneration with the tremors and gait abnormalities characteristic of Parkinson disease. (academic.ru)
  • A diagnostic scoring system has been developed that includes 7 parameters (neurological symptoms, KF rings, Coombs-negative hemolytic anemia, serum ceruloplasmin concentration, urinary copper excretion, liver copper measurement, and genetic mutations) (10). (thefreelibrary.com)
  • Lab Absent serum ceruloplasmin due to a mutation in the ceruloplasmin gene and one or more of the following: low serum copper or iron, high serum ferritin, and increased iron in the glia, neurones, basal ganglia and dentate nucleus, liver cells, and pancreatic islets. (thefreedictionary.com)
  • Ceruloplasmin (Cp) is a glycoprotein secreted by the liver and monocytic cells and probably plays roles in inflammation and iron metabolism. (asm.org)
  • In this report, we have determined serum transferrin (TF) and ceruloplasmin (CP) in patients with liver and renal diseases. (cnki.com.cn)
  • Sheep anti Human ceruloplasmin antibody detects ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. (bio-rad-antibodies.com)
  • Ceruloplasmin is a protein produced by the liver that binds copper for transport in the blood. (reverse-aging.info)
  • Ceruloplasmin has a water-soluble form that circulates in the blood and is primarily made in the liver. (selfhacked.com)
  • Production of ceruloplasmin in the liver is stimulated by thyroid hormones [ 11 ]. (selfhacked.com)
  • In the brain and liver, ceruloplasmin promotes the movement of iron out of cells and loaded onto transferrin , the main iron carrier in blood [ 20 ]. (selfhacked.com)
  • Low levels of ceruloplasmin can cause iron accumulation in the brain, liver, and pancreas. (selfhacked.com)
  • Decreased levels of ceruloplasmin are found in Wilson's Disease, fulminant liver failure, intestinal malabsorption, renal failure resulting in proteinuria, chronic active hepatitis and malnutrition. (labtestingapi.com)
  • In a nutshell, ceruloplasmin is crucial for balancing copper and iron correctly, and testing for it can help give insight to your liver and adrenal health. (sassyholistics.com)
  • Ceruloplasmin doesn't bind iron but it enable iron to be absorbed in the gut, allows it to bind with transferrin (another protein made in the liver), helps red blood cells form, and just allows proper iron metabolism. (sassyholistics.com)
  • Ceruloplasmin as a blood marker is actually used in some liver function panels- so if your number is not in a good range it can give us decent insight on how well your liver is working. (sassyholistics.com)
  • Ceruloplasmin is a protein manufactured in the liver whose main role is to transport copper between the liver where it is stored to the tissues that need it. (biron.com)
  • Ceruloplasmin testing is used primarily, along with blood and/or urine copper tests, to help diagnose Wilson disease, a rare inherited disorder associated with excess storage of copper in the liver, brain, and other organs, and with decreased levels of ceruloplasmin . (grovecanada.ca)
  • Each plasma sample was diluted 6400 fold according to the protocol above and then tested using the Human Ceruloplasmin ELISA Kit. (antibodies-online.com)
  • Our Human Ceruloplasmin ELISA Kit is a sandwich ELISA for the detection of human ceruloplasmin in plasma, serum, lysates , and other biological fluids. (cellbiolabs.com)
  • Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. (wikipedia.org)
  • According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin. (nih.gov)
  • We measured copper, iron, ceruloplasmin (Cp) concentration and activity, transferrin (Tf), ferroxidase activity, and ferritin, and we calculated Tf saturation and Cp to Tf ratio (Cp/Tf) as an index of the activity of the antioxidant Cp-Tf system in 100 children with biopsy-proven NAFLD. (ovid.com)
  • In the present study, we analyzed the amount of ceruloplasmin, iron, ferritin, and transferrin and the ceruloplasmin ferroxidase activity in serum of patients with the diagnosis of PD carrying the ceruloplasmin mutations I63T, D544E, and R793H. (uni.lu)
  • This test measures the amount of ceruloplasmin in your blood. (medlineplus.gov)
  • Measuring the amount of ceruloplasmin is usually prescribed with a blood or urine copper test to help diagnose Wilson's disease, a hereditary disease that interferes with copper removal in bile and results in toxic accumulation of the metal in the tissues. (biron.com)
  • When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains. (hindawi.com)
  • The elevated risk of lung cancer at high concentrations of serum ceruloplasmin persisted after further adjustment for several potential confounding factors such as serum levels of vitamins A and E and selenium. (ox.ac.uk)
  • A rise in plasma haptoglobin concentrations similar to that seen for ceruloplasmin was also observed. (rupress.org)
  • Free, unbound copper concentrations in the blood tend to increase when ceruloplasmin levels are low. (selfhacked.com)
  • Dietary Cu levels had no significant effect (p>0.05) on the plasma ceruloplasmin concentrations in chickens injected with saline. (koreascience.or.kr)
  • Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans. (lsh.is)
  • In twenty healthy Icelandic heterozygotes for WD and their age- and gender-matched controls, copper concentration in plasma, ceruloplasmin (CP) concentration, CP oxidative activity and CP-specific oxidative activity in serum and superoxide dismutase (SOD1) activity in erythrocytes were determined. (dovepress.com)
  • Conventionally, diagnosis of WD is based on at least 2 of the following findings: typical neurological symptoms, presence of Kayser-Fleischer (KF) rings by slit lamp examination, and low serum ceruloplasmin concentration. (thefreelibrary.com)
  • Other biochemical markers have been proposed such as serum free copper concentration (11) and copper:ceruloplasmin ratio (12), but these appear to be less reliable. (thefreelibrary.com)
  • 0.01) in normal pregnancy than pre-eclamptic, but no statistically significant variations were observed in serum zinc, copper and ceruloplasmin concentration. (alliedacademies.org)
  • In vivo, the I63T mutation resulted in half the normal ceruloplasmin concentration and markedly reduced ferroxidase activity in serum from a heteroallelic PD patient. (uni.lu)
  • In this follow-up study concentration, oxidative activity and specific oxidative activity of ceruloplasmin (CP) in serum and the activity of superoxide dismutase (SOD1) in erythrocytes were reexamined in 28 of originally 40 patients with Parkinson's disease (PD), and their age- and gender-matched controls. (lsh.is)
  • Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. (wikipedia.org)
  • Mutations in the ceruloplasmin gene (CP), which are very rare, can lead to the genetic disease aceruloplasminemia, characterized by hyperferritinemia with iron overload. (wikipedia.org)
  • Ceruloplasmin levels may also be decreased in 10-20% of Wilson Disease gene heterozygotes, who do not develop Wilson disease and do not require treatment. (medscape.com)
  • Data (including data from studies in knockout mice) suggest that ceruloplasmin and hephaestin (zeige HEPH ELISA Kits ) play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis. (antikoerper-online.de)
  • We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and highly expressed in intestine. (nih.gov)
  • To better understand the role of ceruloplasmin in iron homeostasis in the CNS, we generated a ceruloplasmin gene-deficient ( Cp −/− ) mouse. (jneurosci.org)
  • Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other extrahepatic tissues. (biochemj.org)
  • Development studies revealed ceruloplasmin gene expression in male and female mammary gland by only 2 weeks of age, prior to the onset of puberty. (biochemj.org)
  • By in situ hybridization, ceruloplasmin gene expression was localized to the epithelium lining the mammary gland alveolar ducts, without evidence of expression in the surrounding mesenchyme. (biochemj.org)
  • Ceruloplasmin gene expression was also detected in a human breast adenocarcinoma cell line and in biopsy tissue from women with invasive ductal carcinoma. (biochemj.org)
  • Taken together, these data indicate that the mammary gland is a prominent site of extrahepatic ceruloplasmin gene expression and add to the evidence that ceruloplasmin biosynthesis is associated with growth and differentiation in non-hepatic tissues. (biochemj.org)
  • Ceruloplasmin ( Cp ) is a ferroxidase enzyme encoded by the CP gene in humans Cp is the main copper-transporting protein in the blood and also functions in iron metabolism. (cellbiolabs.com)
  • Ceruloplasmin test is a test to check ferroxidase enzyme that in humans is encoded by the CP gene. (mfine.co)
  • Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function. (pasteur.fr)
  • Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. (wikipedia.org)
  • Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. (nih.gov)
  • The presence of this site appears as a very rare and distinctive feature of rat Cp as was shown by sequence alignment of ceruloplasmin, hephaestin and zyklopen in the Deuterostomia taxonomic group. (rsc.org)
  • A mouse model systemically deficient in the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) exhibits retinal iron overload similar to that seen in humans with aceruloplasminemia. (arvojournals.org)
  • Evidence supports a regulatory role of both proteins ( Ceruloplasmin (CP ) and beta-amyloid protein precursor (APP (zeige APP ELISA Kits ))) in defence against iron-induced oxidative damage after TBI , which presents as a tractable therapeutic target. (antikoerper-online.de)
  • This review summarizes and updates our knowledge of the nature and functions of ceruloplasmin and the other known and emerging copper-containing molecules (principally proteins) in this fluid, to better understand how they contribute to copper homeostasis and consider their potential significance to health and disease. (rsc.org)
  • Moreover, the relations of the two microorganisms with some Acute Phase Proteins (APPs) inflammatory marker such as Serum Amyloid A (SAA) and Ceruloplasmin (Cp) in serum and milk were inspected. (omicsonline.org)
  • Two common steps: precipitation of bovine plasma proteins with ammonium sulphate (at 35 % and 55 % saturation) followed by column chromatography on AE-Agarose (obtained by treatment of agarose beads with l-chloro-2-ethylamine), lead to an electrophoretically homogeneous ceruloplasmin. (elsevier.com)
  • Ceruloplasmin also belongs to a group of proteins called "acute phase" proteins. (selfhacked.com)
  • According to the current opinion, the copper ions in the human blood serum are distributed between three proteins: ceruloplasmin (CP), albumin (HSA) and alpha-2-macroglobulin (α2M) accounting for approx. (nature.com)
  • Four target proteins, ceruloplasmin (CP), myeloperoxidase (MPO), complement factor H (CFH), and alpha-1-acid glycoprotein (AGP), were chosen for preliminary validation with enzyme linked immunosorbent assay (ELISA) in 20 paired samples at both the time of diagnosis of aGvHD and the time of complete response. (docphin.com)
  • In vivo effects of nickel and cadmium in rats on lipid peroxidation and ceruloplasmin activity. (docphin.com)
  • Solé J, Huguet J, Arola L, Romeu A. In vivo effects of nickel and cadmium in rats on lipid peroxidation and ceruloplasmin activity. (docphin.com)
  • Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: a short review. (lsh.is)
  • Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome. (lsh.is)
  • Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease. (lsh.is)
  • Cu level and ceruloplasmin activity in serum were significantly increased with the increase of dietary Cu. However, the Cu supplementation did not produce any obvious impact on serum superoxide dismutase activity. (mdpi.com)
  • Therefore, the antioxidant effects of ceruloplasmin could have important implications for various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease in which iron deposition is known to occur. (jneurosci.org)
  • Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free radical scavenger. (rsc.org)
  • Ceruloplasmin as an antioxidant in duodenal ulcers. (bvsalud.org)
  • The effects of dietary copper (Cu) supplementation in broiler chickens challenged with a single injection of Salmonella typhymurium lipopolysaccharide (LPS) on the antioxidant capacity and plasma levels of ceruloplasmin (Cp) were evaluated. (koreascience.or.kr)
  • LS-F42846 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Guinea pig CP / Ceruloplasmin. (lsbio.com)
  • It is based upon a Custom assay principle and can be used to detect levels of CP / Ceruloplasmin as low as 0.563 nanograms per millilter. (lsbio.com)
  • LifeLabs is introducing new assay methods for therapeutic drug monitoring (TDM) tests, and for ASOT (antistreptolysin O antibodies / titer), ceruloplasmin and haptoglobin testing. (lifelabs.com)
  • We therefore measured ceruloplasmin in plasma by both chemical and immunological assay methods. (rupress.org)
  • For the non-invasive determination of pregnancy in urine samples we have launched our new Ceruloplasmin (Cp) Colorimetric Activity Assay Kit, K035-H1. (arborassays.com)
  • A human ceruloplasmin standard is provided to generate a standard curve for the assay. (arborassays.com)
  • Ceruloplasmin antibody LS-C685228 is a biotin-conjugated rabbit polyclonal antibody to rat Ceruloplasmin (CP). (lsbio.com)
  • Samples or standards are added to an anti- ceruloplasmin antibody coated plate followed by the addition of a biotinylated anti-human ceruloplasmin antibody. (cellbiolabs.com)
  • Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD. (uni.lu)
  • These results indicate that ceruloplasmin plays an important role in maintaining iron homeostasis in the CNS and in protecting the CNS from iron-mediated free radical injury. (jneurosci.org)
  • These results indicate that ceruloplasmin oxidation contributes to pattern modification in Parkinson's disease. (jneurosci.org)
  • Lower-than-normal ceruloplasmin levels may indicate the following: Wilson disease (a rare [UK incidence 2/100,000] copper storage disease). (wikipedia.org)
  • Menkes disease (Menkes kinky hair syndrome) (rare - UK incidence 1/100,000) Copper deficiency Aceruloplasminemia Zinc toxicity Greater-than-normal ceruloplasmin levels may indicate or be noticed in: copper toxicity / zinc deficiency pregnancy oral contraceptive pill use lymphoma acute and chronic inflammation (it is an acute-phase reactant) rheumatoid arthritis Angina Alzheimer's disease Schizophrenia Obsessive-compulsive disorder Normal blood concentration of ceruloplasmin in humans is 20-50 mg/dL. (wikipedia.org)
  • Ceruloplasmin is high in a variety of neoplastic and inflammatory states, since it behaves as an acute phase reactant, although levels rise more slowly than "acute phase reactants. (labcorp.com)
  • A prolonged period of time may be required to eliminate the excess zinc, overcome the block of intestinal copper absorption and obtain increase in serum copper and ceruloplasmin levels. (labcorp.com)
  • But high levels of ceruloplasmin may also be due to conditions that don't need medical treatment. (medlineplus.gov)
  • Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. (hindawi.com)
  • Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD. (hindawi.com)
  • The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or symptoms suggest a diagnosis of Wilson disease. (medscape.com)
  • Serum ceruloplasmin levels are low in newborns and gradually rise within the first 2 years of life. (medscape.com)
  • Approximately 90% of all patients with Wilson disease have ceruloplasmin levels of less than 20 mg/dL (reference range, 20-40 mg/dL). (medscape.com)
  • Falsely low ceruloplasmin levels may be observed in any protein deficiency state, including nephrotic syndrome, malabsorption, protein-losing enteropathy, and malnutrition. (medscape.com)
  • Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels. (nih.gov)
  • Ceruloplasmin levels were determined from stored serum samples collected at the baseline from these cancer cases and from two matched controls per case. (ox.ac.uk)
  • The most likely explanation of the present results thus is that high serum ceruloplasmin levels in lung cancer are mainly due to occult cancer. (ox.ac.uk)
  • Human white blood cells produce both forms of ceruloplasmin, with peripheral blood lymphocytes having higher levels than all other lymphocyte subsets [ 15 ]. (selfhacked.com)
  • Deficiencies in copper can cause low levels of blood ceruloplasmin because the protein is degraded more quickly when it is not bound to copper [ 19 ]. (selfhacked.com)
  • Elevated levels are found in primary biliary cirrhosis, pregnancy (first trimester), oral contraceptive use and in acute inflammatory conditions since ceruloplasmin is an acute phase reactant. (labtestingapi.com)
  • Ceruloplasmin and low copper levels are found in copper deficiencies and Menkes disease. (biron.com)
  • In Wilson's disease, levels of ceruloplasmin are most often low while levels of urinary and serum copper are high. (biron.com)
  • To better understand the impact of ceruloplasmin blood levels on the risk of cardiovascular disease, and paying special attention to coronary heart disease, we conducted a search on the two most commonly used electronic databases (Medline via PubMed and EMBASE) to analyze current assessment using observational studies in the general adult population. (uco.es)
  • Most of 18 eligible studies reviewed support a direct relationship between ceruloplasmin elevated levels and incidence of coronary heart disease. (uco.es)
  • Our results highlight the importance of promoting clinical trials that determine the functions of ceruloplasmin as a mediator in the development of coronary heart disease and evaluate whether the treatment of elevated ceruloplasmin levels has a role in the prognosis or prevention of this condition. (uco.es)
  • Increasing levels of ceruloplasmin in the samples causes an increase in the fuchsia (pinkpurple) product. (arborassays.com)
  • en] Increased iron levels of the substantia nigra and the discovery of ceruloplasmin mutations in patients with Parkinson's disease (PD) imply impaired iron metabolism in this neurodegenerative disorder. (uni.lu)
  • Furthermore, the D544E polymorphism resulted in significantly reduced serum ceruloplasmin levels and ferroxidase activity in heteroallelic patients and in expression of mainly apo-ceruloplasmin in cell culture. (uni.lu)
  • Forrest plot of risk prediction for serum ceruloplasmin levels according to subgroups. (cdc.gov)
  • The plasma ceruloplasmin levels were significantly increased during the period of aGvHD onset and were markedly decreased as aGvHD resolved. (docphin.com)
  • Furthermore, ceruloplasmin, in vitro, significantly promotes EGCG oxidation accompanied with increasing oxidation products and decreasing levels of reactive oxygen species. (mdpi.com)
  • Excessive therapeutic zinc may lead to block of intestinal absorption of copper and a copper deficiency syndrome characterized by hypochromic microcytic anemia with leukopenia/neutropenia and zero level of ceruloplasmin. (labcorp.com)
  • 1985, Ceruloplasmin and metallothionein induction by zinc and 13-cis-retinoic acid in rats with adjuvant inflammation, Proc. (koreascience.or.kr)
  • The DetectX ® Ceruloplasmin Activity Kit is designed to quantitatively measure ceruloplasmin activity in serum and urine samples. (arborassays.com)
  • The average amount of serum ceruloplasmin in case group was significantly more than control group. (ac.ir)
  • Scheme of the role of ceruloplasmin and hepcidin in the degradation of ferroportin. (nih.gov)
  • We have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed in the mammalian CNS. (jneurosci.org)
  • The second form of ceruloplasmin is anchored to membranes. (selfhacked.com)
  • Copper that is not bound to ceruloplasmin for transport is considered more toxic than copper that is bound. (greatplainslaboratory.com)
  • Between 70 and 95% of the copper in the blood is bound to ceruloplasmin [ 17 , 18 ]. (selfhacked.com)
  • Ceruloplasmin is an acute phase reactant and may be increased in response to hepatic inflammation, pregnancy, estrogen use, or infection. (medscape.com)
  • The LEGENDplex™ Human Acute Phase Panel 1 Mix and Match Beads are individual capture beads for 8 targets including α2-macroglobulin, α1-AGP, Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. (biolegend.com)
  • It allows for the simultaneous quantification of 8 key acute phase molecules including α2-microglobulin, α1-acid glycoprotein (α1-AGP), Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and Serum Amyloid P Component (SAP). (biolegend.com)
  • Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma. (rupress.org)
  • We conclude that the acute phase reactants ceruloplasmin and haptoglobin rise rapidly in the plasma of rabbits bearing the VX2 carcinoma, and that this increase is related to arachidonic acid metabolism in these animals. (rupress.org)
  • Because ceruloplasmin is an acute phase reactant, use caution in interpreting results where inflammation or infection are present. (clevelandheartlab.com)
  • Ceruloplasmin is an "acute-phase" protein. (biron.com)
  • Ceruloplasmin (Cp) is an acute-phase reactant that is increased in inflammatory diseases and in acute coronary syndromes. (cdc.gov)
  • A normal ceruloplasmin does not rule out Wilson's disease. (labcorp.com)
  • Demonstration of failure to incorporate radiolabeled copper into ceruloplasmin is the definitive test for Wilson's disease. (labcorp.com)
  • Low values of ceruloplasmin are found in Wilson's disease, malnutrition, and Menkes kinky hair syndrome. (greatplainslaboratory.com)
  • Ordered with a blood or urine copper test, ceruloplasmin helps in the diagnosis of Wilson's disease. (clevelandheartlab.com)
  • Ceruloplasmin blood tests are used in addition to copper tests to help diagnose Wilson's disease and other disorders of copper metabolism [ 3 , 4 ]. (selfhacked.com)
  • Apoceruloplasmin is largely degraded intracellularly in the hepatocyte and the small amount that is released has a short circulation half life of 5 hours as compared to the 5.5 days for the holo-ceruloplasmin. (wikipedia.org)
  • The impact of these missense mutations on the biosynthesis of holo-ceruloplasmin was investigated in cell culture experiments. (uni.lu)
  • To elucidate the mechanisms of copper incorporation into this protein, holoceruloplasmin biosynthesis was examined by immunoblot analysis and (64)Cu metabolic labeling of Chinese hamster ovary cells transfected with cDNAs encoding wild-type or mutant ceruloplasmin. (mblwhoilibrary.org)
  • Venous blood samples were sent to laboratory to measure ceruloplasmin. (ac.ir)
  • Puchkova, L. 2004-10-18 00:00:00 In vivo biosynthesis of ceruloplasmin (Cp), a copper-containing glycoprotein, which plays an important role in copper transfer between organs and bidirectional iron transport in vertebrates, was studied in 7-day old rats, which are characterized by the embryonic type of copper metabolism. (deepdyve.com)
  • Ceruloplasmin is a multicopper enzyme endowed with ferroxidase activity that is found as a soluble isoform in plasma or as a membrane-associated isoform in specific cell types. (nih.gov)
  • Ceruloplasmin test is conducted to check the level of ferroxidase enzyme in the blood. (mfine.co)
  • Ceruloplasmin (Cp) is an enzyme that is bound to and transports most of the copper in the blood. (selfhacked.com)
  • Injection of a 2.0 mg Cd ²⁺ /kg B.W. (I.P. as CdC1 ₂ in .05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine oxidase activity within one hour of injection. (oregonstate.edu)
  • The experiments involving cadmium suggest the mechanism of cadmium induced inhibition of ceruloplasmin oxidase activity does not involve decreased synthesis. (oregonstate.edu)
  • The in vivo binding of cadmium to ceruloplasmin may be the cause of decreased oxidase activity. (oregonstate.edu)
  • IMSEAR at SEARO: Ceruloplasmin (copper oxidase) activity of serum in patients with various diseases. (who.int)
  • Hereditary ceruloplasmin deficiency , dementia and diabetes mellitus. (thefreedictionary.com)
  • Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family. (thefreedictionary.com)
  • Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. (bio-rad-antibodies.com)
  • Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus. (biochemj.org)
  • In virgin female mammary gland the content of ceruloplasmin mRNA was 20% of that in hepatic tissue from these animals and approx. (biochemj.org)
  • We found expression of ceruloplasmin to be the most enriched in obesity-associated cancer cells. (rice.edu)
  • In summary, we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers. (rice.edu)
  • Fine mapping analysis by integration with genome-wide expression QTLs (eQTLs) from the same BC population identified ceruloplasmin (Cp) as a positional eQTL in macrophages but not in serum. (pasteur.fr)
  • Ceruloplasmin (Cp) is a multicopper ferroxidase that is considered to be an important source of copper in milk for normal neonatal development. (edu.au)
  • Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis. (mblwhoilibrary.org)
  • About 70% or more of total serum copper is associated with ceruloplasmin, 7% with a high MW protein, transcuprein, 19% with albumin, and 2% with amino acids. (labcorp.com)
  • Apart from ceruloplasmin and albumin, most of these components have not been studied extensively, and even for ceruloplasmin and albumin, much remains to be discovered. (rsc.org)
  • It has been reported that Cu(II) ions in human blood are bound mainly to serum albumin (HSA), ceruloplasmin (CP), alpha-2-macroglobulin (α2M) and His, however, data for α2M are very limited and the thermodynamics and kinetics of the copper distribution are not known. (nature.com)
  • Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. (wikipedia.org)
  • Ceruloplasmin is the copper binding protein but it also plays a huge part in iron metabolism. (sassyholistics.com)
  • A purification procedure leading to a joint separation of two serum copper-enzymes: ceruloplasmin (EC 1.16.3.1) and amineoxidase (EC 1.4.3.6), is described. (elsevier.com)
  • A ceruloplasmin test is most often used, along with copper testing, to help diagnose Wilson disease . (medlineplus.gov)
  • Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson disease. (medlineplus.gov)
  • In Wilson disease, copper is not put in ceruloplasmin. (ahealthyme.com)
  • If you have Wilson disease, your ceruloplasmin level will probably be below 10 mg/dL. (ahealthyme.com)
  • Diagnostic accuracy of serum ceruloplasmin in Wilson disease: determination of sensitivity and specificity by ROC curve analysis among ATP7B-genotyped subjects. (thefreelibrary.com)
  • Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. (wikipedia.org)
  • Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. (fishersci.com)
  • The ceruloplasmin is then released into blood plasma. (ahealthyme.com)
  • Detection of Ceruloplasmin in Plasma. (antibodies-online.com)
  • The largest contributor to copper in the plasma is ceruloplasmin, which accounts for 40-70 percent. (rsc.org)
  • Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction. (bio-rad-antibodies.com)
  • Plasma ceruloplasmin and PGE2-M rose in parallel (within 7-10 days) and preceded by 7-10 days the development of hypercalcemia. (rupress.org)
  • 2 wk after tumor implantation, plasma PGE2-M and ceruloplasmin had risen about 20- and 6-fold, respectively, while the rise in plasma calcium was just beginning. (rupress.org)
  • According to this study , ceruloplasmin is essential to get iron to moves from the cells to plasma. (sassyholistics.com)
  • The ceruloplasmin test measures the level of the copper-containing protein ceruloplasmin in the blood. (medlineplus.gov)
  • A lower than normal level of ceruloplasmin may mean your body is not able to use or eliminate copper properly. (medlineplus.gov)
  • Your ceruloplasmin level can be higher than normal because of pregnancy, estrogen therapy, and birth control pills. (ahealthyme.com)
  • Diseases such as leukemia, Hodgkin lymphoma, primary biliary cirrhosis, and rheumatoid arthritis can also cause a higher ceruloplasmin level. (ahealthyme.com)
  • The absorbance is read at 450nm and the level of ceruloplasmin in samples is determined based on the provided human ceruloplasmin standard curve. (cellbiolabs.com)
  • 001560 - This lab test measures the level of Ceruloplasmin in the blood. (mcssl.com)
  • Using two-dimensional electrophoresis, we investigated ceruloplasmin patterns in the CSF of human Parkinson's disease patients. (jneurosci.org)
  • In vitro oxidation of CSF in two-dimensional electrophoresis generated a ceruloplasmin shift resembling that observed in Parkinson's disease and co-occurred with an increase in protein carbonylation. (jneurosci.org)
  • Likewise, increased protein carbonylation was observed in Parkinson's disease CSF, and the same modification was directly identified in these samples on ceruloplasmin. (jneurosci.org)
  • Accordingly, the presence of oxidized ceruloplasmin in Parkinson's disease CSF might be used as a marker for oxidative damage and might provide new insights into the underlying pathological mechanisms. (jneurosci.org)
  • Functional relevance of ceruloplasmin mutations in Parkinson's disease. (uni.lu)
  • A cis-regulatory element called the GAIT element is involved in the selective translational silencing of the Ceruloplasmin transcript. (wikipedia.org)
  • Ceruloplasmin is low in Menkes kinky hair syndrome (In Menkes syndrome the defect is secondary to poor absorption and utilization of dietary copper. (labcorp.com)
  • Low ceruloplasmin might also mean Menkes disease. (ahealthyme.com)
  • Ceruloplasmin stores and carries the mineral copper around your body. (ahealthyme.com)
  • Ceruloplasmin carries 65% to 90% of the copper found in blood. (ahealthyme.com)
  • Ceruloplasmin carries copper around your body to the tissues that need it. (ahealthyme.com)