AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
CeruloplasminCopperHepatolenticular DegenerationIron Metabolism DisordersMetal Metabolism, Inborn ErrorsIronTransferrinLymphangiectasisDeficiency DiseasesTurpentineAnserineHaptoglobinsCation Transport ProteinsApoproteinsCopper SulfateLiver Function TestsEncyclopedias as Topicgamma-GlutamyltransferaseLiver DiseasesLiverProthrombin TimeAspartate Aminotransferases
Ceruloplasmin
Copper
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Hepatolenticular Degeneration
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
Iron Metabolism Disorders
Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)
Metal Metabolism, Inborn Errors
Iron
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Transferrin
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
Lymphangiectasis
A transient dilatation of the lymphatic vessels.
Deficiency Diseases
A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)
Turpentine
The concrete oleoresin obtained from Pinus palustris Mill. (Pinaceae) and other species of Pinus. It contains a volatile oil, to which its properties are due, and to which form it is generally used. (Dorland, 28th ed) Turpentine is used as a solvent and an experimental irritant in biomedical research. Turpentine toxicity is of medical interest.
Anserine
Haptoglobins
Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.
Cation Transport Proteins
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.
Apoproteins
The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).
Copper Sulfate
A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.
Liver Function Tests
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
gamma-Glutamyltransferase
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Liver Diseases
Pathological processes of the LIVER.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Prothrombin Time
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
Aspartate Aminotransferases
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.

The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase antibodies. (1/796)

BACKGROUND: The purpose of this study was to characterize the recently reported inhibition of myeloperoxidase (MPO) by ceruloplasmin and to determine whether this may be disturbed in the presence of anti-MPO antibodies. METHODS: Specificity of the binding between ceruloplasmin and MPO was confirmed by Western blotting and enzyme-linked immunosorbent assay (ELISA), and the enzymatic activity of MPO was measured in the presence of ceruloplasmin, affinity-purified anti-MPO antibodies, or both. The affinity of the binding between MPO and ceruloplasmin and MPO and the anti-MPO antibodies was measured using a biosensor, with the results confirmed by chaotrope ELISA. RESULTS: Affinity-purified anti-MPO antibodies from patients with microscopic polyangiitis and florid renal vasculitis inhibited the binding between ceruloplasmin and MPO to a maximum of 72.9 +/- 12.8%, whereas those from patients with Wegener's granulomatosis and only minimal renal involvement inhibited the binding to a maximum of only 36.8 +/- 10.9% (P < 0. 001), with comparable reversal of the ceruloplasmin-mediated inhibition of MPO activity. Measurement of the affinity of the interactions demonstrated that binding between MPO and the anti-MPO antibodies is stronger than that between MPO and ceruloplasmin (1.61 x 107 to 1.33 x 108 vs. 7.46 x 106 m-1), indicating that binding to the autoantibody would be favored in vivo. CONCLUSIONS: This study confirms a role for ceruloplasmin as a physiological inhibitor of MPO, and demonstrates how the inhibition may be disrupted in the presence of anti-MPO antibodies. Because a majority (16 of 21) of the antibodies did not themselves inhibit MPO activity, their interference with the inhibition mediated by ceruloplasmin may be brought about by steric hindrance consequent upon the binding of the antibody to a dominant epitope at or near the active site.  (+info)

Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation. (2/796)

It is widely accepted that iron deposition in the iron storage protein ferritin in vitro involves Fe(II) oxidation, and that ferritin facilitates this oxidation at a ferroxidase site on the protein. However, these views have recently been questioned, with the protein ferroxidase activity instead being attributed to autoxidation from the buffer alone. Ligand exchange between another protein with ferroxidase activity and ferritin has been proposed as an alternative mechanism for iron incorporation into ferritin. In the present work, a pH stat apparatus is used to eliminate the influence of buffers on iron(II) oxidation. Here we show that the recent experiments questioning the ferroxidase activity of ferritin were flawed by inadequate pH control, that buffers actually retard rather than facilitate iron(II) oxidation, and that horse spleen ferritin has ferroxidase activity when measured under proper experimental conditions. Furthermore, high pH (7.0), a high Fe(II) concentration and the presence of Fe(III) all favour Fe(II) autoxidation in the presence or absence of ferritin.  (+info)

Copper metabolism in retinitis pigmentosa. (3/796)

Clinically and electrophysiologically confirmed cases of primary retinitis pigmentosa have been investigated regarding their copper metabolic state. It is observed that these patients show a normal or near normal serum copper concentration, very low plasma caeruloplasmin concentration, and a very high copper urinary excretion. A similarity between this condition and hepatolenticular degeneration is drawn and it is suggested that retinitis pigmentosa may also be a condition caused by an inborn error of copper metabolism.  (+info)

Caeruloplasmin isoforms in Wilson's disease in neonates. (4/796)

AIM: To investigate the neonatal diagnosis of Wilson's disease from caeruloplasmin isoforms in cord blood. METHODS: Serum caeruloplasmin isoforms were measured in 5-10 ml cord blood from 10 fresh umbilical cords using sodium dodecyl polyacrylamide gel electrophoresis (SDS PAGE) and western blotting and analysed by densitometry. Total caeruloplasmin concentrations were determined by nephelometry and caeruloplasmin oxidase by p-nitrophenyldiamine. RESULTS: Although total caeruloplasmin concentrations are reduced in neonates, the plasma isoform was significantly reduced or absent in patients with Wilson's disease. Sera from healthy neonates and from those with Wilson's disease had reduced biliary isoforms. CONCLUSION: Identification of caeruloplasmin isoforms may be a marker for Wilson's disease in neonates.  (+info)

The reactions of copper proteins with nitric oxide. (5/796)

Nitric oxide (NO) can act as a ligand for copper atoms and may also engage in redox chemistry with the metal once bound. Furthermore NO posses an unpaired electron which can couple with the unpaired electron on Cu2+. These properties have been exploited to probe the active sites of copper-containing enzymes and proteins. We review these studies. In addition to the use as a spectroscopic probe for the active site we draw attention to the rapid reactions of NO at the copper sites in Cytochrome c oxidase (CcO) and laccase. These reactions in CcO occur in the ms time range, at low NO concentrations and in the presence of oxygen and may therefore be of physiological relevance to the control of respiration. Finally we speculate on the wider role that NO may play in regulation of an important group of Type 2 copper containing enzymes.  (+info)

Abnormality in urinary protein excretion in Japanese men with impaired glucose tolerance. (6/796)

OBJECTIVE: To examine whether subjects with impaired glucose tolerance (IGT) for more than 2 years have any abnormality in the kidney. RESEARCH DESIGN AND METHODS: We measured urinary excretion rate and clearance of various plasma proteins with different molecular radii and different isoelectric points in 22 Japanese men with IGT (IGT group) and 37 age-matched healthy control subjects (control group). RESULTS: Clearance of ceruloplasmin (molecular radius approximately 45 A; isoelectric point 4.4), IgG4 (molecular radius 55 A; isoelectric point 5.4), and IgG (molecular radius 55 A; isoelectric point 7.4) was significantly higher in the IGT group than in the control group, whereas there were no significant differences in urinary excretion rate of albumin (molecular radius 36 A; isoelectric points 4.8-5.2) and clearance of alpha 2-macroglobulin (molecular radius 88 A; isoelectric point 5.4) between the two groups. CONCLUSIONS: In the present study, we found that clearance of neutral-charged IgG, negatively charged IgG4, and ceruloplasmin with molecular radii of approximately 45-55 A was selectively increased in IGT subjects. This finding does not seem to be explained by impairment of charge and pore-size selectivity in the glomerulus. Therefore, considering the present result together with our recent finding that enhanced glomerular filtration rate (GFR) after acute protein loading in healthy subjects induced a selective increase in clearance of IgG, IgG4, and ceruloplasmin, we suggest that increased intraglomerular hydraulic pressure, although enhanced GFR was not demonstrated, may be at work in these mildly hyperglycemic subjects.  (+info)

Hepatic hyperplasia and cancer in rats: alterations in copper metabolism. (7/796)

We previously demonstrated that rats exposed to the peroxisome proliferator (PP) diethylhexylphthalate (DEHP) had reduced serum ceruloplasmin (CP) oxidase activity, which suggests tissue copper deposition. Copper is highly toxic in excess, and results in cellular damage and hepatocellular carcinomas (HCC). This study addresses changes in expression of copper-related genes and metal accumulation in hyperplastic liver and tumors induced by PP. Male rats were fed diets containing DEHP or clofibrate (CLF) for 3-60 days (hyperplasia) and 4-chloro-6-(2,3 xylidino)-2-pyrimidinyl-thio(N-beta-hydroxyethyl) acetamide for 10 months (HCC). During hyperplasia, an immediate and progressive decrease in serum CP activity was observed (P < 0.05), as were reductions in mRNA levels for both CP and Wilson's disease gene (WD gene, a P-type ATPase) (P < 0.05). Tumor-bearing rats had lower serum CP activity (P < 0.05), and CP and WD gene mRNA levels were reduced in tumors (P < 0.05), and in liver surrounding tumors (SL) (P < 0.05). Metallothionein mRNA showed no consistent changes during hyperplasia. Tumors showed a 2.5-fold induction of metallothionein mRNA (P < 0.05), and a 1.2-fold increase in SL. Temporal increases in liver copper content occurred during hyperplasia, with increases of 2-fold (DEHP) and 3.3-fold (CLF) at 60 days (P < 0.05). Copper content was 2.2-fold higher in tumors (P < 0.05) and 1.7-fold higher in SL; iron did not increase and zinc decreased temporally. Thus, copper accumulation and changes in copper-related gene expression may be contributing factors in liver neoplasia in PP-treated rats. Loss of CP results in decreased free radical scavenger capacity and thus may enhance oxidative damage induced by PPs.  (+info)

Hemolytic activity of copper sulfate as influenced by epinephrine and chelating thiols. (8/796)

AIM: To study the effects of epinephrine, homocysteine, and other complexing agents on the cytotoxicity of copper sulfate. METHODS: In vitro suspensions of human red cells incubated with cupric sulfate were used, and hemolysis was determined by extracellular hemoglobin. RESULTS: The hemolytic activity of CuSO4 (0.3 mmol.L-1) was enhanced by the presence of epinephrine and to a lesser extent by homocysteine, whereas D-penicillamine, succimer, and mercaptodextran reduced the copper-induced hemolysis. The latter 3 chelating thiols also reduced the copper-epinephrine-induced hemolysis. The plasma protein ceruloplasmin reduced markedly the copper-epinephrine-induced hemolysis, even upon concentrations < 20% of that of copper. Chromic chloride, as well, acted anti-hemolytically. CONCLUSION: The latter protectors may interact with the production or activity of toxic oxygen, while classical copper chelators sequester cupric ions from interaction with epinephrine or homocysteine.  (+info)

Tissue-specific ceruloplasmin gene expression in the mammary gland | Biochemical JournalTissue-specific ceruloplasmin gene expression in the mammary gland | Biochemical Journal
Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat mammary gland tissue from pregnant and lactating animals. Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other extrahepatic tissues. Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus. In virgin female mammary gland the content of ceruloplasmin mRNA was 20% of that in hepatic tissue from these animals and approx. 2-3-fold greater than that found in mammary gland tissue of pregnant or lactating animals. Development studies revealed ceruloplasmin gene expression in male and female mammary gland by only 2 weeks of age, prior to the onset of puberty. Biosynthetic studies indicated that the ceruloplasmin mRNA in ...
http://www.biochemj.org/content/280/3/671
Ceruloplasmin - WikipediaCeruloplasmin - Wikipedia
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. The rest is accounted for by macroglobulins. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. The molecular weight of human ceruloplasmin is reported to be 151kDa. A cis-regulatory element called the ...
https://en.wikipedia.org/wiki/Ceruloplasmin
Ceruloplasmin Activity in Urine and Serum - Arbor Assays | Arbor AssaysCeruloplasmin Activity in Urine and Serum - Arbor Assays | Arbor Assays
Structure of Ceruloplasmin. CP is involved in oxidative stress and in the safe handling of oxygen in some metabolic pathways of vertebrates and has been shown to be associated with reproduction. Serum levels of ceruloplasmin have been found to increase during normal pregnancy in some species and it is thought that this increase during gestation protects against oxidative stress associated with pregnancy. In dogs, the increase in serum ceruloplasmin has been coupled to the time of embryonic endometrial implantation and placentation. In 2011, Erin Willis from the Memphis Zoo published evidence that Cp activity could be correlated to pregnancy status in giant pandas1. The activity of urinary ceruloplasmin was higher during the pregnant luteal phase compared to the pseudopregnant luteal phase. In all term pregnancies examined, levels of active ceruloplasmin were elevated the first week of pregnancy and remained elevated until 20-24 days prior to parturition.. Decreased concentrations occur during ...
https://www.arborassays.com/ceruloplasmin-activity-urine-serum/
Graduate Thesis Or Dissertation | Effect of cadmium on ceruloplasmin levels in the rat | ID: x633f3351 | [email protected]
Injection of a 2.0 mg Cd ²⁺ /kg B.W. (I.P. as CdC1 ₂ in .05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine oxidase activity within one hour of injection. Maximal decrease (40%) occurred within six to eight hours, with levels rising slowly over the duration of the experiment (28.5 hours postinjection). Cadmium-109 (36 pCi carrier free ¹⁰⁹ CdC1 ₂ in .05 M HC1, .15 M NaC1) was injected (I.P.) into rats and plasma obtained five hours later. Purification of the ceruloplasmin using DEAE and Sephadex G-200 chromatography revealed significant cadmium-109 in the ceruloplasmin fraction. In vitro binding was not observed. Attempts were made to purify ceruloplasmin utilizing, DEAE, hydroxylapatite and Sephadex G-200 chromatography coupled with ethanol-chloroform precipitation. The product obtained was spectrophotometrically pure and deemed electrophoretically homogeneous, however antibody produced in rabbits to this ...
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/x633f3351
Copper-related blood indexes in kidney dialysis patients<...
TY - JOUR. T1 - Copper-related blood indexes in kidney dialysis patients. AU - Emenaker, Nancy J.. AU - DiSilvestro, Robert A.. AU - Nahman, N. Stanley. AU - Percival, Susan. PY - 1996/11. Y1 - 1996/11. N2 - Previous work has suggested that kidney hemodialysis patients could be at risk for either moderate copper deficiency or copper toxicity. The present study examined copper-related blood indexes in subjects undergoing hemodialysis treatments with membranes that are not copper-based, in subjects undergoing chronic ambulatory peritoneal dialysis (CAPD), and in control subjects. Both dialysis groups had low plasma copper and ceruloplasmin activities. This occurred despite high plasma interleukin 6 concentrations, a situation that usually elevates plasma ceruloplasmin and copper values. CAPD and hemodialysis subjects had low ratios of ceruloplasmin activity to immunoreactive protein, and low ratios of plasma copper to ceruloplasmin protein. Both are signs of copper deficiency. In contrast, ...
https://augusta.pure.elsevier.com/en/publications/copper-related-blood-indexes-in-kidney-dialysis-patients
Expression of the Caeruloplasmin Gene in the Adult and Neonatal Rat Liver | Clinical ScienceExpression of the Caeruloplasmin Gene in the Adult and Neonatal Rat Liver | Clinical Science
1. It has been suggested that low levels of serum caeruloplasmin in Wilsons disease result from the failure to switch from a fetal to an adult mode of caeruloplasmin gene expression. To investigate postnatal expression of the caeruloplasmin gene, steady-state levels of caeruloplasmin messenger RNA in adult and neonatal rat liver were measured.. 2. Copper parameters observed in neonatal rats were similar to those seen in Wilsons disease: hepatic copper concentration was significantly elevated (neonatal 164 ± 35 μg/g, adults 50 ± 8 μg/g, P , .001) and serum copper and caeruloplasmin levels were low (neonatal 0.5 ± 0.1 μg/ml, adults 1.3 ± 0.2 μg/ml, P , .001; neonatal 0.20 ± 0.04 arbitrary units, adults 0.69 ± 0.16 arbitrary units, P , .001), respectively.. 3. Caeruloplasmin messenger RNA levels were analysed by Northern and dot blotting using a 12P-labelled caeruloplasmin complementary DNA probe. A caeruloplasmin messenger RNA of approximately 4.4 kilobases was detected in both adult ...
http://www.clinsci.org/content/77/3/259
Gentaur Molecular :Alpha Dia \ Mouse Ceruloplasmin protein control for western blot \ CP16-CGentaur Molecular :Alpha Dia \ Mouse Ceruloplasmin protein control for western blot \ CP16-C
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LEGENDplex™ Human Ceruloplasmin Capture Bead B3, 13X, CeruloplasminLEGENDplex™ Human Ceruloplasmin Capture Bead B3, 13X, Ceruloplasmin
The LEGENDplex™ Human Acute Phase Panel 1 Mix and Match Beads are individual capture beads for 8 targets including α2-macroglobulin, α1-AGP, Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. The beads are recommended for use with each other and the following Mix and Matc
https://www.biolegend.com/en-gb/products/legendplex-human-ceruloplasmin-capture-bead-b3-13x-18218
Lung function and cardiovascular risk: relationship with inflammation-sensitive plasma proteins.Lung function and cardiovascular risk: relationship with inflammation-sensitive plasma proteins.
article{6a3b745a-c0d2-4c84-adfb-493281880774, abstract = {Background- The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins.,br/,,br, ,br/,,br, Methods and Results- Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 5064 healthy men aged 28 to 61 years. All-cause mortality, cardiovascular mortality, and incidence of myocardial infarction were monitored over a mean follow-up period of 18.4 years. Low FVC (fourth quartile) was associated with higher protein levels and with increased incidences of myocardial infarction and cardiovascular death. Adjustments for protein levels reduced the age-adjusted relative risks (RRs) for myocardial infarction (from 1.99, 95% CI 1.5 to 2.6, to 1.70, 95% CI 1.3 to 2.2) and cardiovascular death ...
https://lup.lub.lu.se/search/publication/114728
View source for Ceruloplasmin - wikidocView source for Ceruloplasmin - wikidoc
Infobox_gene}} Ceruloplasmin (or caeruloplasmin) is a [[ferroxidase]] [[enzyme]] that in humans is encoded by the CP [[gene]].,ref name=pmid6582496>{{cite journal , vauthors = Takahashi N, Ortel TL, Putnam FW , title = Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule , journal = Proceedings of the National Academy of Sciences of the United States of America , volume = 81 , issue = 2 , pages = 390-4 , date = Jan 1984 , pmid = 6582496 , pmc = 344682 , doi = 10.1073/pnas.81.2.390 }},/ref>,ref name=pmid2873574>{{cite journal , vauthors = Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT , title = Complete cDNA sequence of human preceruloplasmin , journal = Proceedings of the National Academy of Sciences of the United States of America , volume = 83 , issue = 14 , pages = 5086-90 , date = Jul 1986 , pmid = 2873574 , pmc = 323895 , doi = 10.1073/pnas.83.14.5086 }},/ref>,ref name=pmid3474786>{{cite journal , vauthors = Royle ...
http://wikidoc.org/index.php?title=Ceruloplasmin&action=edit
PARKINSONS DISEASE GENE DISCOVERED
ST.LOUIS- The discovery of a gene associated with a rare form of Parkinsons disease provides researchers with a long sought piece to the puzzling pathogenesis of this disease.. A team of researchers at Washington University School of Medicine in St. Louis have characterized a rare disease, aceruloplasminemia, that causes a rare form of Parkinsons. Aceruloplasminemia is caused by a mutation in the ceruloplasmin gene, which is involved in iron transport.. Patients with this gene mutation do not make ceruloplasmin, a protein that removes iron from cells. The iron then accumulates in cells in the brains basal ganglia region and causes neurological problems. These include the tremors and gait abnormalities associated with Parkinsons disease, according to Jonathan D. Gitlin, M.D., associate professor of pediatrics, Washington University School of Medicine.. Neurologists have long hypothesized that Parkinsons disease results from a combination of genetic and environmental factors. The current ...
http://www.accessexcellence.org/WN/SUA03/parkinsons_gene.html
Ceruloplasmin and Heart Failure in the Atherosclerosis Risk in Communities StudyClinical Perspective | Circulation: Heart...Ceruloplasmin and Heart Failure in the Atherosclerosis Risk in Communities StudyClinical Perspective | Circulation: Heart...
Methods and Results-Cp was measured at ARIC visit 4 (1996-1998). We studied 9240 individuals without HF or CVD at ARIC visit 4 and followed them for a mean of 10.5 years. Genome-wide association study was performed to identify genetic determinants of Cp levels and evaluate their association with incident HF in ARIC participants. Cp levels (mean±SD) were higher in women versus men (335±79 versus 258±44 mg/L; P,0.0001), women on versus not on hormone-replacement therapy (398±89 versus 291±60 mg/L; P,0.0001), and African Americans versus whites (299±63 versus 293±74 mg/L; P=0.0005). After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). A locus on the ceruloplasmin gene on chromosome 3 was significantly ...
http://circheartfailure.ahajournals.org/content/6/5/936.short?rss=1
Relationship of serum ceruloplasmin and pre-eclampsia - Journal of Mazandaran University of Medical Sciences
Background and Purpose: Pre-eclampsia is a pregnancy disorder which increases maternal and pre-natal morbidity and mortality. The incidence is about 5% and is influenced by pariety, genetic background, and environmental factors. At present, the sole treatment is termination. It is suitable to use antioxidants for pre-eclampsia prevention. The aim of this ...
http://jmums.mazums.ac.ir/browse.php?a_id=478&sid=1&slc_lang=en
Ceruloplasmin | Profiles RNS
This graph shows the total number of publications written about Ceruloplasmin by people in this website by year, and whether Ceruloplasmin was a major or minor topic of these publications ...
https://researchers.childrensmercy.org/display/5174
Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat...Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie Alzheimers and Parkinsons disease. The linkage between hepcidin (Hepc) and ferroportin-1 (FPN1), the divalent metal transporter 1 (DMT1), and ceruloplasmin (CP) in the brain is unknown. To discern the role of Hepc in regulating the expression of these proteins, we investigated FPN1, DMT1, and CP protein and mRNA expression in the brain after the intracerebroventricular injection of Hepc. Our results show that after Hepc injection, expression of FPN1 mRNA and FPN1 protein was inhibited in the cerebral cortex and hippocampus. Furthermore, we showed a clear change of DMT1 and CP protein and mRNA levels in the brain. The immunohistochemical analysis revealed an increase of DMT1 and a decrease of CP levels. Semi-quantitative analysis using PCR methods showed an increase of DMT1(+IRE) mRNA, and a decrease of DMT1(-IRE) mRNA and CP mRNA levels. Since alterations in iron levels in the brain are ...
https://eprints.lancs.ac.uk/id/eprint/69062/
Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic - Metallomics (RSC Publishing)Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic - Metallomics (RSC Publishing)
Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free radical scavenger. The structural organization of Cp causes its sensitivity to proteolysis and ROS (reactive oxygen species), which can alter some of the important Cp functions. Eluc
http://pubs.rsc.org/en/content/articlelanding/2017/mt/c7mt00157f
Study of impairment in collaboration between ceruloplasmin and transferrin in development of complications in type 2 diabetes...Study of impairment in collaboration between ceruloplasmin and transferrin in development of complications in type 2 diabetes...
Study of impairment in collaboration between ceruloplasmin and transferrin in development of complications in type 2 diabetes mellitus
https://www.msjonline.org/index.php/ijrms/article/view/1182
Ceruloplasmin | Medicína, nemoci, studium na 1. LF UKCeruloplasmin | Medicína, nemoci, studium na 1. LF UK
Ceruloplasmin (též ceruloplazmin) je bílkovinná sloučenina s vlastnostmi enzymu, která je v organizmu důležitá pro transport molekul mědi a pro metabolizmus železa (přeměna iontu Fe2+ na Fe3+). Snížená koncentrace ceruloplasminu je velmi často přítomna u jedinců s Wilsonovou nemocí, není však příčinou jejího vzniku ...
http://www.stefajir.cz/?q=ceruloplasmin
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Private MD - Buy Lab Tests OnlinePrivate MD - Buy Lab Tests Online
Description: The Serum Copper test is, along with serum ceruloplasmin, is used to test for Wilson disease and more frequently used to monitor nutrition, especially when copper deficiency is indicated ...
http://www.privatemdlabs.com/lab_tests.php?view=all&show=772&category=10&search=
Joshua L. Dunaief | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...
Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. The Dunaief lab has found that AMD retinas have iron overload, which can cause oxidative stress. Increased understanding of retinal iron homeostasis may lead to treatments for AMD. To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. A mouse line deficient in the iron transporting ferroxidases ceruloplasmin and hephaestin develops age-dependent retinal iron overload and retinal degeneration with features of AMD (Hahn et al., PNAS, 2004). Recent research in the lab indicates that inflammation promotes cellular iron overload in a vicious cycle leading to cell death. Our current focus is on the mechanisms of retinal iron homeostasis and development of therapeutics to ...
http://www.med.upenn.edu/apps/faculty/index.php/g275/p6071
Encephalopathy Work-up | Peripheral BrainEncephalopathy Work-up | Peripheral Brain
Screening tests Serum glucose, electrolytes, calcium/phosphorus, uric acid, lactate and pyruvate, liver, renal and thyroid function tests, blood gasses Prolactin levels (10 to 20 min after suspected seizure, diagnosis seizure vs. psychogenic nonepileptic seizure) Serum CK ANA, ENA, ANCA, RF, complement, ACE, anti-thyroglobulin and anti-thyroperoxidase antibodies (Hashimoto disease), autoantibody panel (thyroid antimicrosomal, antiparietal), immunoglobulins Serum ceruloplasmin…
https://pbrainmd.wordpress.com/2017/08/18/encephalopathy-work-up/
Ceruloplasmin (Ferroxidase) (CP) ELISA KitsCeruloplasmin (Ferroxidase) (CP) ELISA Kits
Reaktivität: Alle Spezies, Huhn, Rind (Kuh) and more. 90 verschiedene CP ELISA Kits vergleichen. Alle direkt auf antikoerper-online.de bestellbar!
https://www.antikoerper-online.de/transition-metal-ion-homeostasis-pathway-58/cp-elisa-kit-749/
Richard Rosencrantz, Author at Neurology AdvisorRichard Rosencrantz, Author at Neurology Advisor
How can I be sure that the patient has Wilson disease? Overview Wilson disease (WD) is an autosomal recessive disorder that results from mutations in the ATP7B gene located on the long arm of chromosome 13. More than 500 mutations have been identified. ATP7B protein is responsible for both hepatic copper incorporation into ceruloplasmin and…. ...
https://www.neurologyadvisor.com/author/richard-rosencrantz-dsm/
Iron metabolism in placenta (Homo sapiens) - WikiPathwaysIron metabolism in placenta (Homo sapiens) - WikiPathways
Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ; Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.; J Nutr, 2010 PubMed Europe PMC ...
https://www.wikipathways.org/index.php?title=Pathway:WP2007&oldid=43720
Treating Mental and Behavioral Disorders with Nutrient Therapy-Part 6 - Price-PottengerTreating Mental and Behavioral Disorders with Nutrient Therapy-Part 6 - Price-Pottenger
An Interview with William J. Walsh, PhD This is the sixth article in a series of seven articles.. View Part 1, Part 2, Part 3, Part 4 and Part 5.. JH: What kinds of testing do you recommend for patients?. WW: If patients had every blood and urine test that would provide valuable information, they probably wouldnt have any money left - or any blood - so we have to prioritize. Because six or seven factors are dominant in most cases, we start off with a panel of tests that is relatively inexpensive, maybe only $300 or $400. We have to do additional testing in only about ten percent of the cases. We look for markers of oxidative stress and at the important metals, espe-cially zinc and copper, that impact neurotransmitters. We measure the protein called ceruloplasmin because looking at serum copper and ceruloplasmin jointly reveals a lot about free radicals and oxidative stress. We need to have a marker for methylation, and what we have been using is whole blood histamine. Its imperfect, and ...
https://price-pottenger.org/uncategorized/treating-mental-and-behavioral-disorders-with-nutrient-therapy-part-6/
Frataxin, mitochondrialFrataxin, mitochondrial
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1 ...
https://pharos.nih.gov/idg/targets/Q16595
Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2...Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2...
Results of previous studies have shown that the VX2 carcinoma in rabbits synthesizes large amounts of prostaglandin E2 (PGE2). PGE2 secreted by the tumor is rap
https://rupress.org/jem/article/147/4/1078/22401/Acute-phase-reactants-ceruloplasmin-and
Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese - 2013-03-25 - Date of...
健康な日本人におけるセルロプラスミンとフェリチンを含む酸化ストレスバイオマーカーの関連 ...
http://ousar.lib.okayama-u.ac.jp/en/list/dateofgranted/2013-03-25/p/6/item/50680
ISMRM 2017) Hippocampal atrophy is correlated to cerebrospinal fluid levels of ceruloplasmin, neuroinflammation and total tau...ISMRM 2017) Hippocampal atrophy is correlated to cerebrospinal fluid levels of ceruloplasmin, neuroinflammation and total tau...
accounting acidic additional aggravate appears applied assoc atrophy beneficial bottom cellular cognitive college contributed control controls correlated correlation correlations cortex dependent derived determine disease downloaded drive early elderly elucidate enhance explaining export expressed fluid fusiform hand healthy hierarchical homeostasis impairment indicated inflammation institute interact involved iron king kingdom latter marker matched measures metabolism metal mild model negatively operates park pathogenesis pathology positively progression protein proteins psychiatry psychology reactive regression regulatory relationship respectively restore seems significantly stage store subjects suggesting supports synergy therapies tracking true variable variation ventricles volume volumes whereas ...
http://archive.ismrm.org/2017/2359.html
Ceruloplasmin (Cp) Colorimetric Assay kit - ZELLX® - High Quality & Affordable BioAssaysCeruloplasmin (Cp) Colorimetric Assay kit - ZELLX® - High Quality & Affordable BioAssays
Ordering: You can also order using info[at]zellx.de or FAX at +49(0)731 55211719 Technical Support: Customer satisfaction is very important to us. Please call us at +49(0)731 55211521 or send an email to technical[at]zellx.de with your technical questions. A member of our scientific staff will be glad to assist you. ...
https://www.shop-zellx.de/products/colorimetric-assay/ceruloplasmin-cp-assay-kit/
IZH3 (YLR023C) Result Summary | BioGRIDIZH3 (YLR023C) Result Summary | BioGRID
Membrane Protein Involved In Zinc Ion Homeostasis; Member Of The Four-protein IZH Family, Expression Induced By Zinc Deficiency; Deletion Reduces Sensitivity To Elevated Zinc And Shortens Lag Phase, Overexpression Reduces Zap1p Activity
https://thebiogrid.org/31297/protein/saccharomyces-cerevisiae/izh3.html
FET failure - reasons?FET failure - reasons?
I had my first FET with a normal embryo. My RE said it had an 85% chance of implanting, but it didnt. Im looking for reasons this might have happene
http://www.fertilethoughts.com/forums/ivf-and-high-tech/717323-fet-failure-reasons.html
Harga Fetch.ai (FET), grafik, kap pasar, dan metrik lainnya | CoinMarketCapHarga Fetch.ai (FET), grafik, kap pasar, dan metrik lainnya | CoinMarketCap
Get the latest Fetch.ai price, FET market cap, trading pairs, charts and data today from the worlds number one cryptocurrency price-tracking website
https://coinmarketcap.com/id/currencies/fetch/
IVF/FET Sept-Oct 2016 | Page 55 | Bub Hub
I know I am getting in early but figure may as well as I cant be the only one waiting til October to start our FET. I didnt think Id be back here after we got our BFP in March after our first successful round but unfortunately our DD - page 55
https://www.bubhub.com.au/community/forums/showthread.php?556240-IVF-FET-Sept-Oct-2016/page55
Graduate Thesis Or Dissertation | Influence of ascorbic acid supplementation on copper status in young adult men | ID:...
Thirteen healthy adult males, ages 20-40, consuming self selected diets, were given instructions to take one 500 mg tablet of ascorbic acid three times a day with their meals for a period of ten weeks. The effect of this daily supplementation on copper status was investigated. An estimation made from a three day diet record kept by each subject indicated their dietary copper intake to be 1.92 mg per day. Determination of serum ceruloplasmin and serum copper done on the first day of the ascorbic acid supplementation period showed that the subjects fell within accepted ranges of normal. All further determinations of these parameters during the experimental period were compared to initial values so that each subject served as his own control. At week seven the high ascorbic acid intake significantly decreased ceruloplasmin by 26 percent. At the end of the ten week ascorbic acid supplementation period, serum ceruloplasmin activity was significantly lowered by 20 percent. The slight increase over ...
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/9z903296x?locale=en
Aceruloplasminemia - WikipediaAceruloplasminemia - Wikipedia
Aceruloplasminemia is a rare autosomal recessive disorder in which iron gradually accumulates in the retina, basal ganglia, and other organs. Iron accumulation in the brain results in neurological problems that generally appear in adulthood and worsen over time. Aceruloplasminemia has been seen worldwide, but its overall prevalence is unknown. Studies in Japan have estimated that approximately 1 in 2 million adults in this population are affected. Aceruloplasminemia belongs to the group of genetic disorders called neurodegeneration with brain iron accumulation (NBIA). Patients with aceruloplasminemia develop a variety of movement problems. They may experience dystonia of the head and neck, resulting in repetitive movements and contortions. Other involuntary movements may also occur, such as tremors, chorea, blepharospasms, and grimacing. Affected individuals may also experience ataxia, the lack of coordination of muscle movements. Some develop psychiatric problems and midlife dementia. The type ...
https://en.wikipedia.org/wiki/Aceruloplasminemia
Evaluation of Glutathione-S-transferase and ceruloplasmin levels in gingival crevicular fluid and gingival tissue as diagnostic...Evaluation of Glutathione-S-transferase and ceruloplasmin levels in gingival crevicular fluid and gingival tissue as diagnostic...
Periodontitis, is an infectious ailment of multifactorial origin, that brings about destruction of bone and surrounding tissues. There are various oral pathogens that may be responsible for the destruction. The host encounters these microbial invasions and their products by the production and release of inflammatory mediators from the cells within the body. Glutathione-S-transferase (GST) are a group of enzymes that utilize glutathione in conditions resulting in oxidative stress. These enzymes play a key role in the detoxifycation of such substance. It aids in preventing damage to important cellular components caused by release of free reactive oxygen species. Ceruloplasmin is a ferroxidase enzyme. It plays a role as an anti-inflammatory agent, by its ability to scavenge free radicals within the body. The present study was targeted at evaluating the levels of Glutathione-S-Transferase (GST) and Ceruloplasmin as diagnostic markers for patients with chronic periodontitis in gingival crevicular fluid (GCF)
https://scirp.org/journal/papercitationdetails.aspx?paperid=21876&JournalID=164
Copper oxidase | Article about Copper oxidase by The Free DictionaryCopper oxidase | Article about Copper oxidase by The Free Dictionary
Looking for Copper oxidase? Find out information about Copper oxidase. The copper-binding serum protein in human blood. a copper-containing protein of the α2-globulin fraction of blood plasma. It was first discovered and... Explanation of Copper oxidase
http://encyclopedia2.thefreedictionary.com/Copper+oxidase
The Involvement of a Multicopper Oxidase in Iron Uptake by the Green Algae Chlamydomonas reinhardtii | Plant PhysiologyThe Involvement of a Multicopper Oxidase in Iron Uptake by the Green Algae Chlamydomonas reinhardtii | Plant Physiology
In this report, we present novel evidence linking FLP to high-affinity Fe transport and propose that FLP is a ferroxidase, functioning in the reoxidation of Fe2+ before its uptake into the cell. Initial evidence in support of this hypothesis comes from the deduced FLP amino acid sequence. FLP contains two multicopper oxidase I and one multicopper oxidase signature II motifs. In addition, the amino acid sequence of FLP shows the highest homology to multicopper oxidases in mammals (HEPH and ceruloplasmin) and yeast (FET3). These proteins are ferroxidases that are themselves involved in high-affinity Fe assimilation (Stearman et al., 1996;Askwith and Kaplan, 1998; Mukhopadhyay et al., 1998; Attieh et al., 1999; Vulpe et al., 1999). The involvement of FLP in Fe homeostasis is evident from the regulation of its synthesis. Both the transcription of the FLP gene and synthesis of FLP are greatly increased in Fe-deficient cells and reversed after resupply of Fe. Although we have not demonstrated the ...
http://www.plantphysiol.org/content/130/4/2039?ijkey=67f1c70e56669c4b7a6b7d50480c3e108fe41f9e&keytype2=tf_ipsecsha
Spectroscopic evidence for and characterization of a trinuclear ferroxidase center in bacterial ferritin from Desulfovibrio...Spectroscopic evidence for and characterization of a trinuclear ferroxidase center in bacterial ferritin from Desulfovibrio...
Ferritins are ubiquitous and can be found in practically all organisms that utilize Fe. They are composed of 24 subunits forming a hollow sphere with an inner cavity of ~80 A in diameter. The main function of ferritin is to oxidize the cytotoxic Fe(2+) ions and store the oxidized Fe in the inner cavity. It has been established that the initial step of rapid oxidation of Fe(2+) (ferroxidation) by H-type ferritins, found in vertebrates, occurs at a diiron binding center, termed the ferroxidase center. In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C). In an effort to obtain further evidence supporting the presence of a trinuclear Fe binding center in bacterial ferritins and to gain information on the states of the iron bound to the trinuclear ...
http://docentes.fct.unl.pt/ict/publications/spectroscopic-evidence-and-characterization-trinuclear-ferroxidase-center-bacterial
Incidence of Fatal or Repaired Abdominal Aortic Aneurysm in Relation to Inflammation-Sensitive Plasma Proteins. - Lund...Incidence of Fatal or Repaired Abdominal Aortic Aneurysm in Relation to Inflammation-Sensitive Plasma Proteins. - Lund...
Methods and Results- Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future AAA were 0.4%, 1.0%, 1.3%, and 2.3% for men with none, one, two, and ,=3 ISPs, respectively, in the top quartile (trend: P,0.0001). The corresponding odds ratios were 1.00 (reference), 1.9 (95% CI: 0.8 to 4.5), 2.2 (0.9 to 5.5), and 3.2 (1.4 to 7.2), respectively, adjusted for age, screening year, smoking, cholesterol, triglycerides, systolic blood pressure and physical inactivity (trend: P=0.004 ...
https://portal.research.lu.se/portal/en/publications/incidence-of-fatal-or-repaired-abdominal-aortic-aneurysm-in-relation-to-inflammationsensitive-plasma-proteins
Serum copper levels in non-Hodgkins lymphoma | Meta
Levels of serum copper in 34 patients with adult non-Hodgkins lymphoma at different phases of the disease have been studied. All of the patients were evaluated with complete blood counts, sedimentation rate, gallium scintigraphy, liver and bone marrow biopsies, lymph node biopsy, and laparoscopy. The level of serum copper was significantly elevated in non-responding or relapsing patients (mean 191.06 micrograms/dl), and correlated with the estimated tumor burden. Serum copper levels within normal range were found in patients in complete remission (mean 114.76 micrograms/dl). Age- and sex-matched normal controls also showed serum copper levels within normal range (mean 112.81 micrograms/dl). It is proposed that serial measurements of serum copper level may be of use in: (1) monitoring the remission status of patients with non-Hodgkins lymphoma, (2) detecting early relapse of non-Hodgkins lymphoma, and (3) contrary to previous reports by Hrgovcic et al., the level of serum copper seems to be ...
https://www.meta.org/papers/serum-copper-levels-in-non-hodgkins/6989485
Human Biomarkers for Assessing Copper Deficiency - Full Text View - ClinicalTrials.govHuman Biomarkers for Assessing Copper Deficiency - Full Text View - ClinicalTrials.gov
CuD subjects In order to be enrolled into the CuD Arm, subjects who have had RYGB surgery will be recruited and screened for eligibility (inclusion and exclusion criteria below). Subjects whose plasma copper concentrations are in the deficient range (less than 80 μg/dL for women and less than 70 µg/dL for men, and/or ceruloplasmin activity below 62 units/L-1) following 4 weeks of supplementation with the RDA for copper will be eligible. Such supplementation is the routine standard of care with all patients undergoing RYGB surgery. This process aims to exclude patients who were only marginally copper deficient and not in need of sustained copper therapy. Subjects will be notified about their copper status by a study physician. They will be contacted by the study team, and their willingness to participate in the study will be determined.. Inclusion criteria: 1) Patient has a history of RYGB weight loss surgery; 2) subject has a plasma copper level which is less than 80 μg/dL for women andl less ...
https://clinicaltrials.gov/show/NCT01177579
研究論文 - 河野内科 脳神経内科
研究論文業績医学雑誌総説KonoS:Aceruloplasminemia,Curr Drug Targets, 13(9):1190-9, 2012.KonoS.Aceruloplasminemia: an update.Int Rev Neurobiol. 2013;11...
https://konoclinic.net/free/ronbun
View IMJ Articles Details
References 1. Cauza E, Maier-Dobersberger T, Polli C, Kaserer K, Kramer L, Ferenci P. Screening for Wilsons disease in patients with liver diseases by serum ceruloplasmin. Journal of hepatology. 1997;27:358-62. 2. Medici V, Rossaro L, Sturniolo GC. Wilson disease--a practical approach to diagnosis, treatment and follow-up. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2007;39:601-9. 3. Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology (Baltimore, Md). 2008;47:2089-111. 4. Stremmel W, Meyerrose KW, Niederau C, Hefter H, Kreuzpaintner G, Strohmeyer G. Wilson disease: clinical presentation, treatment, and survival. Annals of internal medicine. 1991;115:720-6. 5. Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annual review of nutrition. 2002;22:439-58. 6. Scott J, Gollan JL, Samourian S, Sherlock S. Wilsons disease, presenting as chronic active ...
http://archive.imj.ie/ViewArticleDetails.aspx?ArticleID=15737
Fatality of Future Coronary Events Is Related to Inflammation-Sensitive Plasma Proteins | CirculationFatality of Future Coronary Events Is Related to Inflammation-Sensitive Plasma Proteins | Circulation
The relation between elevated ISPs and an increased incidence of acute coronary events is now well established. Whether the fatality of the events is related to the previous exposure to a low-grade inflammation has been unclear. In the entire cohort, the relative risks were higher for CHD deaths than for nonfatal MI. Among men who subsequently had acute coronary events, the number of elevated ISPs at baseline showed significant associations with the proportions of fatal outcomes (first day or within 28 days). The individual ISPs showed nonsignificant differences between CHD deaths and nonfatal MI. However, in accordance with many previous studies, the prognostic information increased substantially if all 5 ISPs were used.2,11,12,15 The results show that men who have been exposed to a low-grade inflammation many years earlier have higher fatality in future acute coronary events, with a higher proportion of CHD deaths and less nonfatal MI. If this finding can be replicated in other ...
http://circ.ahajournals.org/content/110/1/27
Wilsons Disease, Wilsons Disease Treatment, Wilsons Disease Alternative Medicine, Wilsons Disease Alternative Treatment,...Wilsons Disease, Wilsons Disease Treatment, Wilsons Disease Alternative Medicine, Wilsons Disease Alternative Treatment,...
Wilsons Disease Treatment of Alternative Wilsons Disease Alternative Neuro Acupuncture Treatment and Wilsons Disease Herbal Herbs Alternative Medicine Treatment on Wilsons Disease Treatment Medical Center Wilsons Disease Remedies
http://www.thetole.com/WilsonDiseaseTreatmentCure.html
The Measurement of Serum Transferrin and Ceruloplasmin in Patients with the Liver and Renal Diseases--《Bulletin of Science and...The Measurement of Serum Transferrin and Ceruloplasmin in Patients with the Liver and Renal Diseases--《Bulletin of Science and...
In this report, we have determined serum transferrin (TF) and ceruloplasmin (CP) in patients with liver and renal diseases. Results indicate that TF in all hepatitis groups are significantly lower than that in the nor- mal group. The TF level in patients with abnormal GPT and positive HBsAg are significantly lower than that in normal persons. Therefore, the TF level may be referred to as an index for the hepatitis prognosis. The TF level in nephropathy patients are also lower than that in normal persons. Contents of CP in each group are not similar, for example in patients with hepatic carcinous (52.44±8.73mg％) are significantly higher than that in the normal group (46.75±7.92mg％), but there is no significant difference between hepatic B and normal group. Contents of CP in hepatolenticular degeneration are significantly lower than that in normal group (P 0.001). Therefore, measurement of CP which provides an available objective index is helpful to distingulsh the hepatocirrhosis
http://en.cnki.com.cn/Article_en/CJFDTOTAL-KJTB199302010.htm
CLIENT NOTICE - ONTARIO: CHANGES TO THERAPEUTIC DRUG MONITORING TESTS AND TESTS FOR ASOT, CERULOPLASMIN AND HAPTOGLOBIN -...CLIENT NOTICE - ONTARIO: CHANGES TO THERAPEUTIC DRUG MONITORING TESTS AND TESTS FOR ASOT, CERULOPLASMIN AND HAPTOGLOBIN -...
LifeLabs is introducing new assay methods for therapeutic drug monitoring (TDM) tests, and for ASOT (antistreptolysin O antibodies / titer), ceruloplasmin and haptoglobin testing. For some tests this means a change in the assay platform. A major benefit from these changes is the standardization of the assay methods and reporting across all LifeLabs laboratory sites.. Overall, there will be no significant change to reported results. However we have taken this opportunity to update some of the therapeutic ranges, in accordance with current guidelines, and where appropriate, to update analyte reference intervals.. The change will take place on December 11, 2017. At that time, a message will appear on the affected lab reports indicating the details of the change for each test. Please refer to the lab report for analyte specific messages,therapeutic ranges, orreference intervals.. The following tests are affected:. ...
https://www.lifelabs.com/client-notice-ontario-changes-to-therapeutic-drug-monitoring-tests-and-tests-for-asot-ceruloplasmin-and-haptoglobin/?myProvince=on
Copper and Human HealthCopper and Human Health
Copper and Human Health To say Copper is an essential trace mineral barely does justice when one considers the wide range of vital human bodily functions dependent upon this mighty mineral. To begin with, copper is a major component of hemoglobin, the protein resposible for oxygen transport in blood cells. Copper, along with vitimin C, forms elastin, a protein required to keep skin, blood vessels, and lungs supple and elastic. As an antioxidant, copper plays a strong dual role. First as a central component of both the superoxide dismutase molecule, which protects us from cellular free-radical damage. Secondly, copper helps form the protein ceruloplasmin, which protects us against free-radical damage caused by iron. Copper is also required by the central nervous system as a component in the production of noradrenaline, the brains version of adrenaline and the neurotransmitter that keeps us alert. Copper is also involved in the production of prostaglandins, hormonelike chemicals that regulate ...
http://www.saanendoah.com/cuhumans2.html
Serum copper concentration and coronary heart disease among US adultsSerum copper concentration and coronary heart disease among US adults
Copper, a strong prooxidant, may play a role in atherogenesis. The author examined the association between serum copper concentration and mortality from coronary heart disease using data from the Second National Health and Nutrition Examination Survey (1976-1992). Serum copper concentration was dete …
https://pubmed.ncbi.nlm.nih.gov/10905530/?dopt=Abstract
The FRE for CBYON and GEMS NAV was 0.69 mm a - buildlliibrary85 fun
Further Observations generic cialis available on the Diseases which affect the Synovial Membranes of Joints. Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. Mechanism for hormone-induced alterations in serum ceruloplasmin. Hence, global gene-expression profiling on inguinal lymph nodes was performed 10 days after the induction of pristane-induced arthritis (PIA) and phytol administration.. According to the method used, no generic cialis available significant beneficial effect could be demonstrated in either experimental model. The dichotomous response pattern and positivity offset differed between words and pictures in patients with alcohol dependence. In closed glass containers exposed to about I Mrad of gamma radiation, ozone concentrations up to 18 parts per million (by volume) were recorded. Effect of ...
http://buildlliibrary85.fun/the-fre-for-cbyon-and-gems-nav-was-0-69-mm-a/
Search - NeL.eduSearch - NeL.edu
DESIGN: The test was performed on juvenile fish, which was exposed to Spartakus (concentrations of prochloraz: 0.05; 0.15 and 0.38 mg.L-1) for 28 days. Haematological indices were assessed using unified methods of haematological examination in fish. Plasma biochemical indices were determined by biochemical analyzer. Concentration of total cytochrome P450 (CYP), glutathione (GSH) content and glutathione-S-transferase (GST) activity were determined spectrophotometrically in hepatopancreas. Activity of liver ethoxyresorufin-O-deethylase (EROD) activity was measured spectrofluorimetrically. Ferric reducing ability of plasma (FRAP) and ceruloplasmin activity were assessed spectrophotometrically. Histological changes in samples of hepatopancreas, skin, gills, spleen, head kidney and caudal kidney were examined by light microscopy ...
http://www.nel.edu/journal/search/?keywords=Fungicides
How your cold and flu medicine impacts iron levels | Iron Disorders InstituteHow your cold and flu medicine impacts iron levels | Iron Disorders Institute
Around this time of year, a lot of us are relying heavily on vitamin C and zinc supplements to mediate the effects of a bad cold or flu which can be bacterial or viral in nature. Natural systems in the body, such as the iron withholding defense system (IWDS), are activated to protect us from these pathogens when they invade. Where the IWDS withholds iron, other metals such as copper and zinc and the transport proteins transferrin and ceruloplasmin are present to maintain iron balance.. Copper and zinc - when behaving properly - are boosters of our immune system, powerful antioxidants, and defend us against the overproduction of free radicals generated by too much iron. Transferrin and ceruloplasmin share in the task of keeping us healthy by binding and transporting iron and copper. Transferrin, when too heavily saturated with iron, makes us more susceptible to infection. When too low, ceruloplasmin allows iron and copper to accumulate, resulting in a free radical production bonanza.. Even though ...
https://irondisorders.org/2020/10/29/how-your-cold-and-flu-medicine-impacts-iron-levels/
Mastering Nutrition: 033: Why You Should Manage Your Copper Status and How to Do It
In episode 33, we continue the series on assessing and managing nutritional status. This time we talk about copper. Copper deficiency can cause anemia that is very difficult to tell apart from iron-deficiency anemia, osteoporosis, histamine intolerance, high cholesterol, and a variety of mental effects resulting from neurotransmitter imbalances. Serum copper and ceruloplasmin are excellent tools for assessing nutritional status, but are confounded by inflammation, birth control, menopausal status, and hormone replacement therapy, making it necessary to look at the diet, lifestyle, digestive problems, and other factors that make copper deficiency plausible.  I discuss how to protect yourself from the small risk of copper in your drinking water, and why I think many claims about excess copper outside the context of frank toxicity are misleading. Everything converges on the practical questions of what to do in these situations. You can find the show notes to this episode at chrismasterjohnphd.com/33.
http://thedailylipid.libsyn.com/033-why-you-should-manage-your-copper-status-and-how-to-do-it
Copper deficiency legal definition of Copper deficiencyCopper deficiency legal definition of Copper deficiency
Definition of Copper deficiency in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Copper deficiency? Meaning of Copper deficiency as a legal term. What does Copper deficiency mean in law?
https://legal-dictionary.thefreedictionary.com/Copper+deficiency
Copper deficiency financial definition of Copper deficiencyCopper deficiency financial definition of Copper deficiency
Definition of Copper deficiency in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Copper deficiency? Meaning of Copper deficiency as a finance term. What does Copper deficiency mean in finance?
https://financial-dictionary.thefreedictionary.com/Copper+deficiency
Effect of copper deficiency on prenatal development and pregna...Effect of copper deficiency on prenatal development and pregna...
Effect of copper deficiency on prenatal development and pregnancy outcome.: Copper deficiency during embryonic and fetal development can result in numerous gros
https://www.mysciencework.com/publication/show/effect-copper-deficiency-prenatal-development-pregnancy-outcome-3ac40ba3
Plus itPlus it
Copper is an essential micronutrient for most organisms, especially in respiring eukaryotes, due to its being a cofactor in electron transfer proteins and in enzymes that catalyze redox reactions or oxygen chemistry, such as cytochrome oxidase, ferroxidases, and Cu/Zn superoxide dismutases. The availability of copper in the environment or in the nutrient source may vary widely, however, and copper deficiency is a challenge that many organisms encounter, a challenge they have met through the evolution of sophisticated adaptive mechanisms. At the same time, free copper ions have the potential to participate in Fenton chemistry resulting in the production of reactive oxygen species. Copper assimilation must therefore be tightly regulated so as to meet but not exceed cellular requirements (reviewed in Eide, 1998; Puig and Thiele, 2002; Winge, 2002; Merchant et al., 2006; Pilon et al., 2006),. Genetic and biochemical studies in a number of model organisms have established the existence in eukaryotes ...
http://www.plantcell.org/content/21/3/928
Imperial College Healthcare - Clinical Biochemistry
Copper is an essential trace element. It is required for ferro-oxidase activity which is an essential stage for incorporation of iron into haem. Copper is absorbed in the intestines and then transported to the liver, where it is stored or used in the production of a variety of enzymes. Caeruloplasmin is a copper-containing enzyme that plays a role in the bodys iron metabolism. In the blood, 95 % is bound to caeruloplasmin and 5 % is free. It is used in conjunction with serum copper assay to help diagnose Wilsons disease and evaluate copper metabolism.. ...
http://pathology.imperial.nhs.uk/index.php?mact=Products,cntnt01,details,0&cntnt01productid=4497&cntnt01returnid=39
Valtsus: January 2014Valtsus: January 2014
Normally food copper is metabolized by the liver and channeled into safe pathways such as being incorporated in to ceruloplasmin. [...] When we administer inorganic copper orally labeled with 64Cu, we see a fraction of the label appear in the blood in 1-2 hours, too soon to be processed by the liver. [...] We believe this fraction of 64Cu-labeled inorganic copper is bypassing the liver, is therefore not incorporated safely into ceruloplasmin, contributes directly to the nonceruloplasmin free copper pool, and represents what is happening to at least a portion of the inorganic copper ingested in drinking water or copper supplements.[32] ...
http://valtsus.blogspot.fi/2014/01/
Venöse Multiple Sklerose, CVI & SVI, CCSVI - facebook prikbord - CCSVI.nl
We found an age-related increase of iron in the white matter of controls as well as in patients with short disease duration. In chronic MS, however, there was a significant decrease of iron in the normal-appearing white matter (NAWM) corresponding with disease duration, when corrected for age. This decrease of iron in oligodendrocytes and myelin was associated with an upregulation of iron-exporting ferroxidases. In active MS lesions, iron was apparently released from dying oligodendrocytes, resulting in extracellular accumulation of iron and uptake into microglia and macrophages. Iron-containing microglia showed signs of cell degeneration. At lesion edges and within centers of lesions, iron accumulated in astrocytes and axons ...
http://www.ccsvi.nl/prikbord/Direct.aspx?guid=117471578700_10155717831578701
Wilson Disease - Pearls - Family Practice Faculty NotesWilson Disease - Pearls - Family Practice Faculty Notes
Wilsons disease (-) ceruloplasmin does not rule out Keyser-Fleischer rings absent in 50% AST & ALT |1500 Normal or low alk phos for age (cofactor Zn displaced by Cu) AST:ALT |2.2 AlkPhos : TotBili |4
https://fpfacultynotes.wordpress.com/2016/11/01/wilson-disease-pearls/
Wilson DiseaseWilson Disease
簡介 Wilson disease是一種銅代謝異常的體染色體隱性疾病，常會造成肝臟的受損和神經精神病變。 銅的代謝 正常人一天大約會攝入1-2mg的銅，其中約10%會被身體吸收 被吸收的銅，會和albumin結合，送到肝臟代謝 到肝臟之後，WDP (ATP7B)蛋白能夠協助銅的代謝 →能協助銅和運銅蛋白結合，以ceruloplasmin的形式進入血中 →也可協助銅經由膽汁排泄 病生理機轉 為體染色體隱性疾病，因為ATP7B基因的突變，導致銅代謝異常 因為銅無法被排入膽汁→導致膽汁的...
https://thetinynotes.com/topic/539/wilson-disease
Relationship of serum copper and zinc to human hypertension in Nigerians*Relationship of serum copper and zinc to human hypertension in Nigerians*
Olatunbosun, D. A., Bolodeoku, J. O., Cole, T. O. & Adadevoh, B. K. (‎1976)‎. Relationship of serum copper and zinc to human hypertension in Nigerians*. Bulletin of the World Health Organization, 53 (‎1)‎, 134 - 135. https://apps.who.int/iris/handle/10665/260875 ...
https://apps.who.int/iris/handle/10665/260875
Phase II Study of Tetrathiomolybdate (TM) in Patients With Breast CancerPhase II Study of Tetrathiomolybdate (TM) in Patients With Breast Cancer
Patients with moderate to high risk primary breast cancer (Stage II with more than 4 lymph nodes involved with cancer) III or Stage IV (without evidence
http://www.knowcancer.com/cancer-trials/NCT00195091/
Wilsons disease: MRI with clinical correlationWilsons disease: MRI with clinical correlation
We tried to establish possible correlations between clinical data and MRI in a group of patients with Wilsons disease. Eleven patients (6 male, 5 female), aged between 11 and 50 years old, with a duration of illness from 5 months to 32 years, were submitted to MRI on a 1.5 T System. Three patients …
https://pubmed.ncbi.nlm.nih.gov/8183467/?dopt=Abstract
Wilsons Disease - UChicago MedicineWilsons Disease - UChicago Medicine
Our physicians collaborate closely to diagnose and treat Wilsons disease. Treatment depends on the organs involved and overall health of the patient.
https://www.uchicagomedicine.org/conditions-services/liver-diseases/wilsons-disease
WILSONS DISEASE | Harrisons Manual of MedicineWILSONS DISEASE | Harrisons Manual of Medicine
WILSONS DISEASE answers are found in the Harrisons Manual of Medicine powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623685/all/WILSON_S_DISEASE
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Serum levels rise for other proteins, cialis 5mg wirkungseintritt such as ceruloplasmin, complement proteins, haptoglobin, fibrinogen, and C-reactive
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Topley & Wilsons microbiology and microbial infections - کتابخانه دیجیتال دانشگاه علوم پزشکی تهرانTopley & Wilsons microbiology and microbial infections - کتابخانه دیجیتال دانشگاه علوم پزشکی تهران
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http://lib.tums.ac.ir/site/catalogue/1701
Spanish researchers have cured Wilsons Disease in murine | EURAXESSSpanish researchers have cured Wilsons Disease in murine | EURAXESS
University of Navarra CIMA scientists have used gene therapy to develop a vector which corrects the origin and reverses the symptoms of this rare hepatic disease. The research is the cover article of the Journal of Hepatology, the most prestigious scientific journal in its field. See the full article attached.
https://euraxess.ec.europa.eu/europe/news/spanish-researchers-have-cured-wilson%E2%80%99s-disease-murine
Tom Wilsons late goal forces OT as Caps gain a point in loss to PenguinsTom Wilsons late goal forces OT as Caps gain a point in loss to Penguins
Jake Guentzel scored the winner for Pittsburgh, but not before Tom Wilsons goal in the final seconds of regulation forced overtime.
https://sports.yahoo.com/tom-wilsons-goal-forces-ot-225305864.html
Free versus bioavailable...Free versus bioavailable...
Just thinking out loud... Question: How valuable is it knowing SHBG numbers mid-cycle? seems it would be more helpful to know between cycles, right?
https://forums.steroid.com/
The Fastest ISPs In the US - SlashdotThe Fastest ISPs In the US - Slashdot
adeelarshad82 writes For a second year in a row PCMag partnered with Speedtest to find out the fastest ISPs in the U.S. The results were a product of 110,000 tests ran between January 1, 2012 and September 19, 2012. Collecting data for both download and upload speeds for each test, Speednet was abl...
https://tech.slashdot.org/story/12/10/01/1828208/the-fastest-isps-in-the-us
Demovere Xeno - Viewing Profile - The Allspark ForumsDemovere Xeno - Viewing Profile - The Allspark Forums
17 January 2018 - 10:36 PM) Closest I got to free was 30% off warpath, which just about lined him up to the canadian price had he ever shown up around me. The pile of loot saved me a pile, but it was still pricy.. ...
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Page contains details about few-layer SnS2 FET . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
http://nano.nature.com/nano/GR-D5566713
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last year when I had my FET I was supremely confident it would work (tw it did, but I mced) PLUS I had been testing and poasing and knew by then I was...
https://forums.thebump.com/discussion/comment/90552322/
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(Quote) last year when I had my FET I was supremely confident it would work (tw it did, but I mced) PLUS I had been testing and poasing and knew by then I was...
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https://altergusto.net/ft245r-datasheet-25/
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There have been some moments of true desperation during our 13-year history. This is one of them.. (Shortcut: GoFundMe / website / Vipps at 4151 4638). Icepeople is again facing an immediate existential crisis due (of course) to hardships largely inflected by the pandemic. In short, 1) the website needs $22 U.S. (190 NOK) to stay online for another month and 2) the editor needs any and all help possible to avoid homelessness in the middle of polar winter (not that its legal here any other time of the year).. So if you appreciate Icepeople for its unique stories about Svalbard and/or critical news during these critical times, as well as its features about the more colorful aspects of life here (todays feature about the upcoming Polarjazz festival is for the event that first drew our editors attention to Svalbard way back in 2008) please do whatever you can during what are admittedly incredibly harsh times for many.. Donations can be made at:. • Icepeoples GoFundMe. • Icepeoples direct ...
https://icepeople.net/tag/frisbee-golf/
CeruloplasminCeruloplasmin
... (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major ... Ceruloplasmin can be measured by means of a blood test; this can be done using immunoassays . The sample is spun and separated ... Ceruloplasmin is a relatively large enzyme (~10nm); the larger size prevents the bound copper from being lost in a person's ... Ceruloplasmin (CP) is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. ...
https://en.wikipedia.org/wiki/Ceruloplasmin
Wilsons diseaseWilson's disease
There is no totally reliable test for Wilson's disease, but levels of ceruloplasmin and copper in the blood, as well of the ... Copper accumulates in the liver tissue; ceruloplasmin is still secreted, but in a form that lacks copper (termed apo- ... The liver also releases copper into the bloodstream that is not bound to ceruloplasmin. This free copper precipitates ... ceruloplasmin) and is rapidly degraded in the bloodstream. When the amount of copper in the liver overwhelms the proteins that ...
https://en.wikipedia.org/wiki/Wilson's_disease
Beta-galactoside alpha-2,6-sialyltransferaseBeta-galactoside alpha-2,6-sialyltransferase
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH (1970). "Physical and chemical studies on ceruloplasmin. 8. ... Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin". J. Biol. Chem. 245 (4): 759-66. PMID 4313609. Paulson JC, ...
https://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase
Copper deficiencyCopper deficiency
Ceruloplasmin also oxidizes iron from its ferrous state to the ferric form that is required for iron binding. Impairment in ... Low levels of copper and ceruloplasmin in the serum are consistent with the diagnosis as is a low 24 hour urine copper level. ... Another iron transporting enzyme is ceruloplasmin. This enzyme is required to mobilize iron from the reticuloendothelial cell ... ceruloplasmin, Cu/Zn superoxide dismutase, and in amine oxidases. These enzyme catalyze reactions for oxidative phosphorylation ...
https://en.wikipedia.org/wiki/Copper_deficiency
Gel electrophoresis of proteinsGel electrophoresis of proteins
α2 - haptoglobin, α2-macroglobulin, α2-antiplasmin, ceruloplasmin. The beta (β) band - transferrin, LDL, complement The gamma ( ...
https://en.wikipedia.org/wiki/Gel_electrophoresis_of_proteins
Multicopper oxidaseMulticopper oxidase
... s include: Ceruloplasmin EC 1.16.3.1 (ferroxidase), a 6-domain enzyme found in the serum of mammals and ... Messerschmidt A, Huber R (January 1990). "The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and ...
https://en.wikipedia.org/wiki/Multicopper_oxidase
Estradiol undecylateEstradiol undecylate
The effects of estradiol undecylate on serum lipids and ceruloplasmin levels have been studied as well. Additionally, the ... Götz H, Ehrmeier H (June 1971). "[Estrogens and ceruloplasmine level]" [Estrogens and ceruloplasmin levels]. Archiv Fur ...
https://en.wikipedia.org/wiki/Estradiol_undecylate
Blood plasmaBlood plasma
Green color can be due to ceruloplasmin or sulfhemoglobin. The latter may form due to medicines that are able to form ...
https://en.wikipedia.org/wiki/Blood_plasma
Nutritional neuroscienceNutritional neuroscience
Wolf T. L.; Kotun J.; Meador-Woodruff J. H. (2006). "Plasma copper, iron, ceruloplasmin and ferroxidase activity in ...
https://en.wikipedia.org/wiki/Nutritional_neuroscience
GAIT elementGAIT element
Ceruloplasmin is also an acute-phase protein produced by monocytes, and its plasma concentration can double during multiple ... Mazumder B, Sampath P, Fox PL (2005). "Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated ... Mazumder B, Sampath P, Fox PL (2006). "Translational control of ceruloplasmin gene expression: beyond the IRE". Biol Res. 39 (1 ... UTR of the ceruloplasmin (Cp) mRNA. The GAIT element forms a stem-loop secondary structure. The GAIT element is involved in ...
https://en.wikipedia.org/wiki/GAIT_element
HephaestinHephaestin
While deficiency in hephaestin or ceruloplasmin alone do not seem to cause iron buildup in the retina, studies done on murine ... Human iron metabolism Ceruloplasmin GRCh38: Ensembl release 89: ENSG00000089472 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... While the structure and kinetic activity of ceruloplasmin have been studied extensively, hephaestin has yet to be investigated ... While hephaestin shares 50% amino acid sequence identity with its serum homologue ceruloplasmin, the hephaestin protein ...
https://en.wikipedia.org/wiki/Hephaestin
Sertoli cellSertoli cell
... a ceruloplasmin-like protein which is immunologically similar to serum ceruloplasmin. The occluding junctions of Sertoli cells ... Skinner MK, Griswold MD (June 1983). "Sertoli cells synthesize and secrete a ceruloplasmin-like protein". Biology of ... a blood plasma protein for iron ion delivery testicular ceruloplasmin, ...
https://en.wikipedia.org/wiki/Sertoli_cell
CopperCopper
... which involves the protein ceruloplasmin, carrying the majority of copper in blood. Ceruloplasmin also carries the copper that ... Severe deficiency can be found by testing for low plasma or serum copper levels, low ceruloplasmin, and low red blood cell ... S.S. Percival; Harris, E.D. (1 January 1990). "Copper transport from ceruloplasmin: Characterization of the cellular uptake ... Frieden, E.; Hsieh, H.S. (1976). Ceruloplasmin: The copper transport protein with essential oxidase activity. Advances in ...
https://en.wikipedia.org/wiki/Copper
Liver function testsLiver function tests
Ceruloplasmin is an acute phase protein synthesized in the liver. It is the carrier of the copper ion. Its level is increased ... In Wilson disease, the ceruloplasmin level is depressed which lead to copper accumulation in body tissues. AFP is significantly ...
https://en.wikipedia.org/wiki/Liver_function_tests
MetalloproteinMetalloprotein
Ceruloplasmin is the major copper-carrying protein in the blood. Ceruloplasmin exhibits oxidase activity, which is associated ...
https://en.wikipedia.org/wiki/Metalloprotein
FerroxidaseFerroxidase
Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol ... Ceruloplasmin FTH1 - Ferritin heavy chain FTMT - Ferritin, mitochondrial HEPH - Hephaestin Cox JC, Boxer DH (1986). "The role ...
https://en.wikipedia.org/wiki/Ferroxidase
Monoclonal gammopathyMonoclonal gammopathy
The α2 region is mostly haptoglobin, α2-macroglobulin, α2-antiplasmin, and ceruloplasmin. The β band consists of transferrin, ...
https://en.wikipedia.org/wiki/Monoclonal_gammopathy
Copper in biologyCopper in biology
The majority of blood copper (or serum copper) is bound to ceruloplasmin. The proportion of ceruloplasmin-bound copper can ... ATP7B directs copper to plasma ceruloplasmin or to biliary excretion in concert with a newly discovered chaperone, Murr1, the ... Most of the copper (70 - 95%) excreted by the liver is incorporated into ceruloplasmin, the main copper carrier in blood. ... Copper is transported to extra-hepatic tissues by ceruloplasmin, albumin and amino acids, or excreted into the bile. By ...
https://en.wikipedia.org/wiki/Copper_in_biology
AceruloplasminemiaAceruloplasminemia
Ceruloplasmin helps move iron from the organs and tissues of the body and prepares it for incorporation into a molecule called ... When ceruloplasmin is unavailable, transport of iron out of the body's tissues is impaired. The resulting iron accumulation ... The CP gene mutation results in the production of ceruloplasmin protein that is unstable or nonfunctional by altering the open ... Diagnosis of this disorder depends on blood tests demonstrating the absence of serum ceruloplasmin, combined with low serum ...
https://en.wikipedia.org/wiki/Aceruloplasminemia
Florica TopârceanuFlorica Topârceanu
"Considerations about the possible function of ceruloplasmin in influenza and parainfluenza virus infection". www. ...
https://en.wikipedia.org/wiki/Florica_Topârceanu
Nicola RoyleNicola Royle
"Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular ...
https://en.wikipedia.org/wiki/Nicola_Royle
ThrombinThrombin
"Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular ...
https://en.wikipedia.org/wiki/Thrombin
Robert J. CousinsRobert J. Cousins
Special reference to metallothionein and ceruloplasmin". Physiological Reviews. 65 (2): 238-309. doi:10.1152/physrev.1985.65. ...
https://en.wikipedia.org/wiki/Robert_J._Cousins
Acute-phase proteinAcute-phase protein
... ceruloplasmin, serum amyloid A and haptoglobin. Others give negative feedback on the inflammatory response, e.g. serpins. Alpha ...
https://en.wikipedia.org/wiki/Acute-phase_protein
CLCN4CLCN4
ClC-4 promotes copper incorporation into ceruloplasmin". Gastroenterology. 126 (4): 1157-66. doi:10.1053/j.gastro.2004.01.015. ...
https://en.wikipedia.org/wiki/CLCN4
Nutritional anemiaNutritional anemia
... ceruloplasmin), optimal functions of the erythrocyte membrane. Ceruloplasmin (copper containing protein) is required for normal ...
https://en.wikipedia.org/wiki/Nutritional_anemia
HepatocyteHepatocyte
... ceruloplasmin, transferrin, complement, and glycoproteins. Hepatocytes manufacture their own structural proteins and ...
https://en.wikipedia.org/wiki/Hepatocyte
Asialoglycoprotein receptorAsialoglycoprotein receptor
"Physical and Chemical Studies on Ceruloplasmin: V. METABOLIC STUDIES ON SIALIC ACID-FREE CERULOPLASMIN IN VIVO". Journal of ... The researchers transferred radioactively-labeled ceruloplasmin that had undergone a reaction via the enzyme neuraminidase to ...
https://en.wikipedia.org/wiki/Asialoglycoprotein_receptor
Amyloid-beta precursor proteinAmyloid-beta precursor protein
These iron-transporters can then be activated by known mammalian ferroxidases (i.e. ceruloplasmin or hephaestin). The amyloid-β ... on Alzheimer's is revealed by a mouse study that has found that APP possesses ferroxidase activity similar to ceruloplasmin, ...
https://en.wikipedia.org/wiki/Amyloid-beta_precursor_protein
Reference ranges for blood testsReference ranges for blood tests
Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper. Note: ...
https://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests
Ceruloplasmin Test: MedlinePlus Medical TestCeruloplasmin Test: MedlinePlus Medical Test
Ceruloplasmin is a protein that stores and carries copper to your bloodstream. If the test shows too much or too little copper ... This test measures the amount of ceruloplasmin in your blood. ... Other names: CP, ceruloplasmin blood test, ceruloplasmin, serum ... What is a ceruloplasmin test?. This test measures the amount of ceruloplasmin in your blood. Ceruloplasmin is a protein that is ... Why do I need a ceruloplasmin test?. Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson ...
https://medlineplus.gov/lab-tests/ceruloplasmin-test/
Wilson Disease Workup: Approach Considerations, Serum Ceruloplasmin, Urinary Copper Excretion and Hepatic Copper ConcentrationWilson Disease Workup: Approach Considerations, Serum Ceruloplasmin, Urinary Copper Excretion and Hepatic Copper Concentration
Serum Ceruloplasmin. Serum ceruloplasmin levels are low in newborns and gradually rise within the first 2 years of life. ... Ceruloplasmin levels may also be decreased in 10%-20% of Wilson Disease gene heterozygotes, who do not develop Wilson disease ... The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or ... Falsely low ceruloplasmin levels may be observed in any protein deficiency state, including nephrotic syndrome, malabsorption, ...
https://www.medscape.com/answers/183456-68980/what-is-the-role-of-radiolabeled-copper-testing-in-the-workup-of-wilson-disease
Tourette Syndrome and Other Tic Disorders Workup: Approach Considerations, Serum Ceruloplasmin or Slit-Lamp Examination,...Tourette Syndrome and Other Tic Disorders Workup: Approach Considerations, Serum Ceruloplasmin or Slit-Lamp Examination,...
Serum Ceruloplasmin or Slit-Lamp Examination. Serum ceruloplasmin or slit lamp examination for Kayser-Fleischer rings might be ...
https://emedicine.medscape.com/article/1182258-workup
Radical reactions from missing ceruloplasmin | NeurologyRadical reactions from missing ceruloplasmin | Neurology
Radical reactions from missing ceruloplasmin. The importance of a ferroxidase as an endogenous antioxidant. W.D. Graf, M.J. ... Ceruloplasmin has enzymatic activity as a plasma ferroxidase and mediates the oxidation of ferrous to ferric iron for insertion ... Ceruloplasmin has been believed to transport copper in the blood. However, recent studies of copper metabolism suggest that ... Even though 95% of plasma copper is contained in ceruloplasmin, this copper does not exchange freely with tissue copper and ...
https://n.neurology.org/content/53/3/446
Binding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin? | Lund University PublicationsBinding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin? | Lund University Publications
Correspondingly the binding of MPO to ceruloplasmin-coated plates could be blocked by ceruloplasmin in solution, showing a ... Correspondingly the binding of MPO to ceruloplasmin-coated plates could be blocked by ceruloplasmin in solution, showing a ... myeloperoxidase, ceruloplasmin, complement C3d, glomerulonephritis, ANCA. in Clinical and Experimental Immunology. volume. 108 ... We propose that ceruloplasmin takes part in the clearance and inactivation of MPO, in vivo. We also speculate that impaired ...
https://lup.lub.lu.se/search/publication/1111851
Ceruloplasmin
Clinlabnavigator is the only and best place to read articles on Ceruloplasmin ... Ceruloplasmin Ceruloplasmin is an alpha2 globulin that carries more than 95% of all copper in the body. Both ceruloplasmin ... Normally, ceruloplasmin is synthesized in hepatocytes as an apo-ceruloplasmin and secreted into the plasma after copper is ... The most common laboratory finding is a low plasma ceruloplasmin. Other laboratory findings include:. *Decreased ceruloplasmin ...
http://www.clinlabnavigator.com/ceruloplasmin.html
Ceruloplasmin - AccuteqsCeruloplasmin - Accuteqs
Ceruloplasmin Deprecated: Function get_magic_quotes_gpc() is deprecated in /home/ozoei4ngo532/public_html/wp-content/themes/ ...
https://accuteqs.com.ph/ceruloplasmin/
Liver function tests - WikipediaLiver function tests - Wikipedia
Main article: Ceruloplasmin. Ceruloplasmin is an acute phase protein synthesized in the liver. It is the carrier of the copper ... In Wilson disease, the ceruloplasmin level is depressed which lead to copper accumulation in body tissues.[7] ...
https://en.wikipedia.org/wiki/Liver_function_tests
Ceruloplasmin - MRM ProteomicsCeruloplasmin - MRM Proteomics
MRM Proteomics Inc. was established in 2010 as a spin-out company to commercialize the cutting-edge proteomics technologies, tools and know-how developed at the University of Victoria-Genome BC Proteomics Centre.. ...
https://mrmproteomics.com/product/ceruloplasmin/
Ceruloplasmin | Profiles RNS
"Ceruloplasmin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Ceruloplasmin" by people in this website by year, and whether ... Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitors. J Child Neurol ... Case of desmoplastic infantile ganglioglioma secreting ceruloplasmin. J Child Neurol. 2005 Nov; 20(11):920-4. ...
https://profiles.musc.edu/display/86827/
Ceruloplasmin - Temple StreetCeruloplasmin - Temple Street
This cookie is installed by Google Analytics. The cookie is used to store information of how visitors use a website and helps in creating an analytics report of how the wbsite is doing. The data collected including the number visitors, the source where they have come from, and the pages viisted in an anonymous form ...
https://www.cuh.ie/lab_test/ceruloplasmin/
IMSEAR at SEARO: Serum ceruloplasmin in infective hepatitis.
Serum ceruloplasmin in infective hepatitis. Indian Journal of Pathology & Microbiology. 1985 Jul; 28(3): 215-8. ...
https://imsear.searo.who.int/handle/123456789/72738
CERULOPLASMIN - Probomed Labs DiagnosticCERULOPLASMIN - Probomed Labs Diagnostic
Probo Med labs is the leading diagnostics laboratory in India with the door to door service.. ...
https://probomedlabs.com/product/ceruloplasmin/
Category: Ceruloplasmin - Courtney Snyder MD - Holistic PsychiatristCategory: Ceruloplasmin - Courtney Snyder MD - Holistic Psychiatrist
Ceruloplasmin Cesarean Section Child Abuse Child-Friendly Children Chronic Fatigue Chronic Fatigue Syndrome Compassion Complex ...
https://www.courtneysnydermd.com/blog/category/ceruloplasmin
PRESTIGE 24i CERULOPLASMIN - CERULOPLASMIN - Products Cormay DiagnosticsPRESTIGE 24i CERULOPLASMIN - CERULOPLASMIN - Products Cormay Diagnostics
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https://cormaydiagnostics.com/products/clinical-chemistry/parameters/ceruloplasmin/prestige-24i-ceruloplasmin
Ceruloplasmin Deficiency, Oxidative Stress and Iron | Second Opinion Physician
Ceruloplasmin deficiency is associated with anxiety and elevated norepinephrine. Supplement remedies improve levels and reduce ... This entry was posted in Copper Overload and tagged Alzheimers, Ceruloplasmin, Copper, Free Copper, Iron, Magnesium. Mast ... Ceruloplasmin levels rise with inflammation and tends to follow copper levels. But the wider the gap rises between total copper ... He refers to this as "MT Promoter" a sulfur rich blend of amino acids that increase ceruloplasmin production. The use of MT ...
https://www.secondopinionphysician.com/ceruloplasmin-deficiency-oxidative-stress-and-iron/
New mutation of the ceruloplasmin gene in the case of a neurologically asymptomatic patient with microcytic anaemia, obesity...New mutation of the ceruloplasmin gene in the case of a neurologically asymptomatic patient with microcytic anaemia, obesity...
Molecular genetic examination of the CP gene for ceruloplasmin identified a new variant c.1664G > A (p.Gly555Glu) in the ... during the search for the cause of hepatopathy with very low values of serum ceruloplasmin. ... Aceruloplasminaemia is a very rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene, which is ... The membrane-bound form of ceruloplasmin, associated with glycosylphosphatidylinositol (GPI-ceruloplasmin), is expressed in ...
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01237-8
Ceruloplasmin Test Cost in Ahmedabad | Get up to 50% Off on MFineCeruloplasmin Test Cost in Ahmedabad | Get up to 50% Off on MFine
Book Ceruloplasmin Test in Ahmedabad using the MFine app. Get up to 50% Off with at-home sample collection and reports from ... Is ceruloplasmin a definitive test?. Ceruloplasmin test is an effective test to measure the ceruloplasmin in the blood which ... Ceruloplasmin test in Ahmedabad. Avail Ceruloplasmin test in Ahmedabad through MFine. You can book your Ceruloplasmin test from ... Why book a ceruloplasmin test?. Mostly you will book the ceruloplasmin test when your doctor suggests you do so. The test ...
https://www.mfine.co/lab-test/ceruloplasmin-test-in-ahmedabad
Metabolic Panel Plus (Kryptopyrrole, Copper Serum, Zinc Plasma, Histamine Whole Blood, Ceruloplasmin) - DHA LaboratoryMetabolic Panel Plus (Kryptopyrrole, Copper Serum, Zinc Plasma, Histamine Whole Blood, Ceruloplasmin) - DHA Laboratory
Whole Blood Histamine and Ceruloplasmin. The Metabolic Panel P ... Ceruloplasmin is used in the evaluation of oxidative stress. ... An estimated 95% of copper in the blood is bound to ceruloplasmin. As a result, only a very small amount of copper is found in ... When paired with other blood or urine copper tests, ceruloplasmin is used to help diagnose Wilsons disease. This is due to a ... The Whole Blood Histamine, Copper Serum, Zinc plasma, and Ceruloplasmin will require a blood draw. We will provide the patient ...
https://www.dhalab.com/shop/metabolic-panel-plus-draimie/
Table 1 - Recent US Case of Variant Creutzfeldt-Jakob Disease-Global Implications - Volume 21, Number 5-May 2015 - Emerging...
Ceruloplasmin, mg/dL. 32.5 (20.0-60.0). Creatine kinase, U/L. 39-257 (0.6-1.3). ...
https://wwwnc.cdc.gov/eid/article/21/5/14-2017-t1
Immunochimie / Immunoturbidimétrie protéines sériques - SPINREACTImmunochimie / Immunoturbidimétrie protéines sériques - SPINREACT
Tardive Dyskinesia: Overview, Pathophysiology, EtiologyTardive Dyskinesia: Overview, Pathophysiology, Etiology
Check serum ceruloplasmin and the copper transporter gene in every patient in whom Wilson disease is suspected. The onset of ... Deficiency of serum ceruloplasmin due to an abnormal copper transporter gene characterizes Wilson disease. Urine copper ... Check serum ceruloplasmin and the copper transporter gene in patients who may have Wilson disease. ... Serum biochemistry, serum copper, serum ceruloplasmin, thyroid function tests, and syphilis serology to evaluate tardive ...
https://emedicine.medscape.com/article/1151826-overview
Wilsons DiseaseWilson's Disease
Serum ceruloplasmin levela Low in about 85% of cases. Same as symptomatic. Low (,15 mg%) in about 15-20% of cases. Normal. ... Because ceruloplasmin acts as an acute phase reactant as well as a copper transporter, falsely high levels will be seen when ... Low levels of ceruloplasmin can also be found in cases of Menkes disease, hereditary aceruloplasminemia, protein-losing ... The value is determined by subtracting three times the ceruloplasmin level (mg/dl) from the total serum copper level (µg/dl). ...
https://www.medscape.com/viewarticle/543866_5
Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer - Full Text View - ClinicalTrials.govPhase II Trial of Disulfiram With Copper in Metastatic Breast Cancer - Full Text View - ClinicalTrials.gov
Serum ceruloplasmin , 17 mg/dL. *Able and willing to sign informed consent and to comply with study procedures ...
https://clinicaltrials.gov/show/NCT03323346
Plasma protein thiols, ceruloplasmin, C-reactive protein and RBC acetylcholinesterase in patients undergoing intrauterine...Plasma protein thiols, ceruloplasmin, C-reactive protein and RBC acetylcholinesterase in patients undergoing intrauterine...
Plasma protein thiols, ceruloplasmin, C-reactive protein and RBC acetylcholinesterase in patients undergoing intrauterine ... Hypothesis: Changes in levels of acetylcholinesterase, protein thiols, ceruloplasmin and C- reactive proteins following ... ceruloplasmin, C-reactive protein and RBC acetylcholinesterase in patients undergoing intrauterine insemination. In: ... We observed a significant decrease in plasma ceruloplasmin, protein thiols and RBC acetylcholinesterase (p,0.001) following ...
http://eprints.manipal.edu/139235/
Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin...Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin...
Transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin concentrations [arithmetic mean (±SD)] ... Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin ...
https://avesis.ktu.edu.tr/yayin/55767798-2199-4637-964d-d7a47646fcaa/reference-values-of-cord-blood-transferrin-ceruloplasmin-alpha-1-antitrypsin-prealbumin-and-alpha-2-macroglobulin-concentrations-in-healthy-term-newborns
Analysis and establish a correlation between serum ceruloplasmin, serum apelin level and thyroid profile in patients with...Analysis and establish a correlation between serum ceruloplasmin, serum apelin level and thyroid profile in patients with...
Analysis and establish a correlation between serum ceruloplasmin, serum apelin level and thyroid profile in patients with ...
https://www.msjonline.org/index.php/ijrms/article/view/11405/7406
Erowid.org: References DatabaseErowid.org: References Database
Ceruloplasmin Adrenaline Oxidase and Schizophrenia Dis. Nerv. System. 1965. MH Keeler. Similarity of Schizophrenia and the ...
https://www.erowid.org/references/refs.php?S=schizophrenia
ProteinFerroxidaseBound to ceruloplasminAmount of ceruloplasminOxidative StressFalselyUrinaryZincAmino AcidsAcuteConcentrationsTransferrinPlasmaAutosomal recessiveProteinsDegradationInflammationGeneAlbuminLevelsHepaticAntioxidantDeficiencyConcentrationWilson'sMyeloperoxidaseCopper in the bUrineNormalExaminationMolecularInhibitionLevelMeSHMetabolismAbnormalitiesTestIronSymptomsProductionTotalBody
Protein9
  • Ceruloplasmin is a protein that is made in the liver. (medlineplus.gov)
  • Falsely low ceruloplasmin levels may be observed in any protein deficiency state, including nephrotic syndrome, malabsorption, protein-losing enteropathy, and malnutrition. (medscape.com)
  • The protein was identified as ceruloplasmin by N-terminal amino acid sequencing and immunochemistry. (lu.se)
  • Low levels of ceruloplasmin can also be found in cases of Menkes disease, hereditary aceruloplasminemia, protein-losing enteropathy including celiac disease and severe hepatic insufficiency, and in heterozygous carriers of WD. (medscape.com)
  • Hypothesis: Changes in levels of acetylcholinesterase, protein thiols, ceruloplasmin and C- reactive proteins following intrauterine insemination may be responsible for overall poor success rate of intrauterine insemination. (manipal.edu)
  • Here, we investigated whether copper and the primary copper-containing protein, ceruloplasmin, are mobilized to urine during naturally occurring UTI caused by Gram-positive uropathogens in patients. (asm.org)
  • To investigate the influence of Plasmodium falciparum malaria on plasma antioxidants and lipid peroxidation, plasma ascorbate, urate, total protein and albumin, ceruloplasmin and malondialdehyde (MDA) were determined in two groups of 42 patients each, one with mild and the other with severe falciparum malaria, and in an equal number of age- and sex-matched control subjects. (ajtmh.org)
  • Also levels of the acute phase protein, ceruloplasmin, were brought to their normal range in DME-treated rats. (nih.gov)
  • El defecto en el transporte del cobre a través de las membranas plasmáticas y del retículo endoplásmico hace que no se disponga de cobre para la síntesis de varias enzimas que lo contienen, como la PROTEIN-LISINA 6-OXIDASA, CERULOPLASMINA y SUPERÓXIDO DISMUTASA. (bvsalud.org)
Ferroxidase1
  • Ceruloplasmin has enzymatic activity as a plasma ferroxidase and mediates the oxidation of ferrous to ferric iron for insertion into apotransferrin. (neurology.org)
Bound to ceruloplasmin3
  • Copper absorbed from the gastrointestinal tract is bound to ceruloplasmin in the liver and transported to various tissues to be incorporated into cellular cytochrome oxidase and other copper containing enzymes. (clinlabnavigator.com)
  • Copper bound to ceruloplasmin is nontoxic. (clinlabnavigator.com)
  • An estimated 95% of copper in the blood is bound to ceruloplasmin. (dhalab.com)
Amount of ceruloplasmin2
  • This test measures the amount of ceruloplasmin in your blood. (medlineplus.gov)
  • A lower-than-normal amount of ceruloplasmin may indicate that your body is unable to adequately utilize or remove copper. (mfine.co)
Oxidative Stress2
  • Practitioners who evaluate patients mental health condition look to the ratio of ceruloplasmin and total copper and plasma zinc to determine the level of oxidative stress on the body. (secondopinionphysician.com)
  • Ceruloplasmin is used in the evaluation of oxidative stress. (dhalab.com)
Falsely3
  • Falsely normal ceruloplasmin values can be seen with estrogen therapy, pregnancy, and acute inflammation. (clinlabnavigator.com)
  • Because ceruloplasmin acts as an acute phase reactant as well as a copper transporter, falsely high levels will be seen when patients have active inflammation, are pregnant, or are taking estrogens. (medscape.com)
  • This measurement is valuable in cases in which falsely high levels of serum ceruloplasmin are suspected, and when a measurement of urinary copper is difficult to obtain. (medscape.com)
Urinary2
  • WD is biochemically characterized by low ceruloplasmin and total serum copper levels, increased 24-hour urinary copper excretion, and abnormally high hepatic copper content. (medscape.com)
  • Our findings demonstrate that urinary copper and ceruloplasmin content are elevated during UTI caused by Enterococcus faecalis , S. aureus , S. epidermidis , and S. saprophyticus . (asm.org)
Zinc3
  • Controlling symptoms of copper overload involves a daily antioxidant supplement regimen plus, when zinc levels are normalized, use of an amino acid blend that Walsh has formulated that increases ceruloplasmin levels. (secondopinionphysician.com)
  • The Whole Blood Histamine, Copper Serum, Zinc plasma, and Ceruloplasmin will require a blood draw. (dhalab.com)
  • The effect of low concentration dietary cadmium (7440439) on hemoglobin, hematocrit and serum amylase, zinc (7440666), copper (7440508), and ceruloplasmin was studied in male rats fed a semipurified diet. (cdc.gov)
Amino Acids1
  • He refers to this as "MT Promoter" a sulfur rich blend of amino acids that increase ceruloplasmin production. (secondopinionphysician.com)
Acute1
  • Ceruloplasmin is an acute phase reactant and may be increased in response to hepatic inflammation, pregnancy, estrogen use, or infection. (medscape.com)
Concentrations2
  • Transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin concentrations [arithmetic mean (±SD)] were found to be 199.7 (±34.6) mg/dl, 14.6 (±4.0) mg/dl, 160.2 (±23.6) mg/dl, 11.9 (±2.2) mg/dl, and 284.6 (±44.4) mg/dl, respectively. (ktu.edu.tr)
  • Cadmium feeding had a similar effect on serum copper and ceruloplasmin concentrations in male and female rats. (cdc.gov)
Transferrin1
  • Following the degradation of erythrocytes, ceruloplasmin releases iron from the reticuloendothelial system for recycling via transferrin. (neurology.org)
Plasma5
  • Even though 95% of plasma copper is contained in ceruloplasmin, this copper does not exchange freely with tissue copper and copper does not regulate ceruloplasmin turnover. (neurology.org)
  • During separation procedures the peroxidase inhibitory effect was limited to ceruloplasmin-containing fractions of plasma. (lu.se)
  • Normally, ceruloplasmin is synthesized in hepatocytes as an apo-ceruloplasmin and secreted into the plasma after copper is incorporated into a metal-binding motif, forming holo-ceruloplasmin. (clinlabnavigator.com)
  • The most common laboratory finding is a low plasma ceruloplasmin. (clinlabnavigator.com)
  • Plasma ceruloplasmin was slightly elevated. (who.int)
Autosomal recessive3
  • Instead, in the rare autosomal recessive condition aceruloplasminemia, the absence of ceruloplasmin profoundly influences the biological activity and distribution of tissue iron. (neurology.org)
  • Aceruloplasminaemia is a very rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene, which is clinically manifested by damage to the nervous system and retinal degeneration. (biomedcentral.com)
  • Aceruloplasminaemia is a rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene linked to the accumulation of iron in an organism, mainly in the liver, brain, retina and pancreas. (biomedcentral.com)
Proteins1
  • Correspondingly the binding of MPO to ceruloplasmin-coated plates could be blocked by ceruloplasmin in solution, showing a physical interaction to occur between the two proteins under physiological conditions. (lu.se)
Degradation1
  • In patients with Wilson disease, loss of ATP7b activity results in failure of copper incorporation into ceruloplasmin, secretion of apo-ceruloplasmin, and rapid degradation. (clinlabnavigator.com)
Inflammation1
Gene3
  • Ceruloplasmin levels may also be decreased in 10%-20% of Wilson Disease gene heterozygotes, who do not develop Wilson disease and do not require treatment. (medscape.com)
  • Individuals without Kayser Fleischer rings who have subnormal ceruloplasmin and abnormal liver function tests should undergo further testing for ATP7B gene mutations. (clinlabnavigator.com)
  • Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease. (cdc.gov)
Albumin2
  • Of the antioxidants, ascorbate and albumin decreased with severity of disease while urate and ceruloplasmin increased. (ajtmh.org)
  • In the present study serum ceruloplasmin and albumin levels were determined in 75 patients of tuberculosis, of which 25 were fre. (researchgate.net)
Levels6
  • But high levels of ceruloplasmin may also be due to conditions that don't need medical treatment. (medlineplus.gov)
  • The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or symptoms suggest a diagnosis of Wilson disease. (medscape.com)
  • Serum ceruloplasmin levels are low in newborns and gradually rise within the first 2 years of life. (medscape.com)
  • Approximately 90% of all patients with Wilson disease have ceruloplasmin levels of less than 20 mg/dL (reference range, 20-40 mg/dL). (medscape.com)
  • Low levels need to be interpreted cautiously because any type of severe liver disease may interfere with ceruloplasmin synthesis. (clinlabnavigator.com)
  • Fundoscopy, skeletal survey, serum copper and ceruloplasmin levels were normal. (cdlib.org)
Hepatic2
  • If a patient is asymptomatic, exhibits isolated liver disease, and lacks corneal rings, the coexistence of a hepatic copper concentration of more than 250 mcg/g of dry weight and a low serum ceruloplasmin level is sufficient to establish a diagnosis. (medscape.com)
  • This mutation results in 2 defects in hepatic copper metabolism: a decrease in the incorporation of copper into ceruloplasmin and diminished biliary excretion of copper. (clinlabnavigator.com)
Antioxidant1
  • Serum level and antioxidant activity of ceruloplasmin in preeclampsia. (scialert.net)
Deficiency1
  • The ceruloplasmin test can also help in detecting the deficiency of copper in the body. (mfine.co)
Concentration1
  • Purified ceruloplasmin inhibited the peroxidase activity of MPO in a concentration-dependent manner, and exhibited selective binding to MPO-coated microtitre. (lu.se)
Wilson's2
  • In our report, we describe the case of a patient with aceruloplasminaemia, which was identified in an early, neurologically asymptomatic stage while searching for the cause of chronic hepatopathy with low values of serum ceruloplasmin with originally supposed Wilson's disease. (biomedcentral.com)
  • When paired with other blood or urine copper tests, ceruloplasmin is used to help diagnose Wilson's disease. (dhalab.com)
Myeloperoxidase1
  • Binding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin? (lu.se)
Copper in the b1
  • Ceruloplasmin has been believed to transport copper in the blood. (neurology.org)
Urine1
  • Ceruloplasmin reference range is 20 - 45 mg/dL, serum copper 0.75 - 1.45 ng/mL, urine copper 15 - 60 ug/24 hour specimen. (clinlabnavigator.com)
Normal3
  • A lower than normal level of ceruloplasmin may mean your body is not able to use or eliminate copper properly. (medlineplus.gov)
  • In fact, copper metabolism is normal in persons who lack ceruloplasmin. (neurology.org)
  • No additional requirements are to be fulfilled while taking the ceruloplasmin test as this is a normal test where the blood is drawn from the arm. (mfine.co)
Examination1
  • Serum ceruloplasmin or slit lamp examination for Kayser-Fleischer rings might be considered. (medscape.com)
Molecular2
  • Finally, molecular modelling revealed that hyper-truncated Asn355-glycans positioned in the MPO-ceruloplasmin interface are critical for uninterrupted inhibition. (glycosciences.de)
  • Its chemical name is 17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate with the empirical formula of C 22 H 28 O 3 and a molecular weight of 340.5. (rxlist.com)
Inhibition1
  • Enzymatic trimming of the Asn355-/Asn391-glycans recapitulated the activity gain and showed that nMPO carrying hyper-truncated glycans at these positions exhibits increased thermal stability, polypeptide accessibility and ceruloplasmin-mediated inhibition potential relative to native nMPO. (glycosciences.de)
Level3
  • Book a ceruloplasmin test to check your ceruloplasmin level! (mfine.co)
  • Measurement of the serum ceruloplasmin level is important. (medscape.com)
  • The value is determined by subtracting three times the ceruloplasmin level (mg/dl) from the total serum copper level (µg/dl). (medscape.com)
MeSH1
  • Ceruloplasmin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Metabolism1
  • However, recent studies of copper metabolism suggest that ceruloplasmin is important for iron, not copper, metabolism. (neurology.org)
Abnormalities1
  • The ceruloplasmin test will help determine the copper related abnormalities in the body. (mfine.co)
Test21
  • What is a ceruloplasmin test? (medlineplus.gov)
  • A ceruloplasmin test is most often used, along with copper testing, to help diagnose Wilson disease . (medlineplus.gov)
  • Why do I need a ceruloplasmin test? (medlineplus.gov)
  • Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson disease. (medlineplus.gov)
  • What happens during a ceruloplasmin test? (medlineplus.gov)
  • You don't need any special preparations for a ceruloplasmin test. (medlineplus.gov)
  • Is there anything else I need to know about a ceruloplasmin test? (medlineplus.gov)
  • A useful test to determine copper ceruloplasmin is the Copper Biotype Panel. (secondopinionphysician.com)
  • Avail Ceruloplasmin test in Ahmedabad through MFine. (mfine.co)
  • You can book your Ceruloplasmin test from the reputed lab partners of MFine and get samples collected from your doorstep. (mfine.co)
  • A Ceruloplasmin test is usually recommended for patients who are experiencing symptoms such as trouble in swallowing, changes in behavior, abdominal pain, jaundice, etc. (mfine.co)
  • How to Book a Ceruloplasmin Test in Ahmedabad? (mfine.co)
  • A lab technician will collect your Ceruloplasmin test sample in the scheduled slot. (mfine.co)
  • What is the ceruloplasmin test used for? (mfine.co)
  • What is included in the ceruloplasmin test? (mfine.co)
  • Ceruloplasmin test is done if your healthcare provider anticipates that you may have Wilson syndrome. (mfine.co)
  • Procedure for ceruloplasmin test? (mfine.co)
  • The procedure for the ceruloplasmin test requires the blood sample to be taken from the body. (mfine.co)
  • The blood sample drawn out will be sealed in a tube and taken out for lab work so that the ceruloplasmin test can be carried out. (mfine.co)
  • How to prepare for the ceruloplasmin test? (mfine.co)
  • What types of conditions can the ceruloplasmin test detect? (mfine.co)
Iron1
  • Other researchers have found that iron, another trace element in the body, lowers ceruloplasmin when present in the unbound oxidative form, ferrous iron. (secondopinionphysician.com)
Symptoms1
  • In our report, we describe the case of a patient with aceruloplasminaemia detected in an early stage (without clinical symptoms of damage to the nervous system) during the search for the cause of hepatopathy with very low values of serum ceruloplasmin. (biomedcentral.com)
Production2
  • Both ceruloplasmin production and copper binding take place in the liver. (clinlabnavigator.com)
  • Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitors. (musc.edu)
Total2
  • This graph shows the total number of publications written about "Ceruloplasmin" by people in this website by year, and whether "Ceruloplasmin" was a major or minor topic of these publications. (musc.edu)
  • But the wider the gap rises between total copper and ceruloplasmin indicates the degree of free copper. (secondopinionphysician.com)
Body1
  • Ceruloplasmin is an alpha 2 globulin that carries more than 95% of all copper in the body. (clinlabnavigator.com)
(emedicine.medscape.com)
MedlinePlus: Genes: C
MedlinePlus: Genes: C (medlineplus.gov)
Lupus Nephritis Workup: Approach Considerations, Laboratory Tests for Renal Function in SLE, Laboratory Tests for SLE Disease...
Lupus Nephritis Workup: Approach Considerations, Laboratory Tests for Renal Function in SLE, Laboratory Tests for SLE Disease... (medscape.com)
Prueba de ceruloplasmina: Prueba de laboratorio de MedlinePlus
Prueba de ceruloplasmina: Prueba de laboratorio de MedlinePlus (medlineplus.gov)
Wilson Disease: Practice Essentials, Background, Etiology
Wilson Disease: Practice Essentials, Background, Etiology (medscape.com)
Wilson Disease: Practice Essentials, Background, Etiology
Wilson Disease: Practice Essentials, Background, Etiology (medscape.com)
Wilson Disease Clinical Presentation: History, Physical Examination
Wilson Disease Clinical Presentation: History, Physical Examination (medscape.com)
Aceruloplasminemia: MedlinePlus Genetics
Aceruloplasminemia: MedlinePlus Genetics (medlineplus.gov)
Wilson disease: MedlinePlus Medical Encyclopedia
Wilson disease: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Ciglitazone - Ontology Report - Rat Genome Database
Ciglitazone - Ontology Report - Rat Genome Database (rgd.mcw.edu)
Primary Biliary Cholangitis (Primary Biliary Cirrhosis): Practice Essentials, Background, Pathophysiology
Primary Biliary Cholangitis (Primary Biliary Cirrhosis): Practice Essentials, Background, Pathophysiology (emedicine.medscape.com)
(emedicine.medscape.com)
Essential Tremor: Practice Essentials, Background, Etiology
Essential Tremor: Practice Essentials, Background, Etiology (medscape.com)
Sideroblastic Anemias: Practice Essentials, Background, Pathophysiology
Sideroblastic Anemias: Practice Essentials, Background, Pathophysiology (emedicine.medscape.com)
Tardive Dyskinesia: Overview, Pathophysiology, Etiology
Tardive Dyskinesia: Overview, Pathophysiology, Etiology (emedicine.medscape.com)
Radical reactions from missing ceruloplasmin | Neurology
Radical reactions from missing ceruloplasmin | Neurology (n.neurology.org)
Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer - Full Text View - ClinicalTrials.gov
Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Acute Liver Failure: Practice Essentials, Background, Pathophysiology
Acute Liver Failure: Practice Essentials, Background, Pathophysiology (medscape.com)
Parkinson Disease Workup: Approach Considerations, Radiologic Studies, Histologic Findings
Parkinson Disease Workup: Approach Considerations, Radiologic Studies, Histologic Findings (medscape.com)
Parkinson Disease Workup: Approach Considerations, Radiologic Studies, Histologic Findings
Parkinson Disease Workup: Approach Considerations, Radiologic Studies, Histologic Findings (medscape.com)
Isoniazid Toxicity Workup: Approach Considerations, Laboratory Studies, Other Studies
Isoniazid Toxicity Workup: Approach Considerations, Laboratory Studies, Other Studies (emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)