Cerebrospinal Fluid Proteins: Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)Hematoma: A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.Intracranial Embolism and Thrombosis: Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.Cerebral Hemorrhage, Traumatic: Bleeding into one or both CEREBRAL HEMISPHERES due to TRAUMA. Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. Depending on the severity of bleeding, clinical features may include SEIZURES; APHASIA; VISION DISORDERS; MOVEMENT DISORDERS; PARALYSIS; and COMA.Intracranial Thrombosis: Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.Basal Ganglia Hemorrhage: Bleeding within the subcortical regions of cerebral hemispheres (BASAL GANGLIA). It is often associated with HYPERTENSION or ARTERIOVENOUS MALFORMATIONS. Clinical manifestations may include HEADACHE; DYSKINESIAS; and HEMIPARESIS.Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Pinellia: A plant genus of the family ARACEAE that contains pinellian (an acidic polysaccharide). The plant is an ingredient of some traditional Asian medicinal mixtures including sho-saiko-to, saiko-keishi-to, and banxia houpu decoction.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Meningoencephalitis: An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.Streptococcus suis: A species of STREPTOCOCCUS isolated from pigs. It is a pathogen of swine but rarely occurs in humans.Proteome: The protein complement of an organism coded for by its genome.Electrophoresis, Gel, Two-Dimensional: Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.Meningitis, Bacterial: Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)tau Proteins: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Spinal Puncture: Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Glycols: A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.Equipment Reuse: Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.Fungal Proteins: Proteins found in any species of fungus.Indenes: A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.Amyloid beta-Peptides: Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Amyloid beta-Protein Precursor: A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.Lithostathine: The proteinaceous component of the pancreatic stone in patients with PANCREATITIS.Needles: Sharp instruments used for puncturing or suturing.Post-Dural Puncture Headache: A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Herbal Medicine: The study of medicines derived from botanical sources.Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.Warts: Benign epidermal proliferations or tumors; some are viral in origin.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.History, 20th Century: Time period from 1901 through 2000 of the common era.Amyloid: A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Amyloid Precursor Protein Secretases: Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.Glycopeptides: Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Plaque, Amyloid: Accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Cerebral Amyloid Angiopathy: A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)

Spinal reflexes and the concentrations of 5-HIAA, MHPG, and HVA in lumbar cereborspinal fluid after spinal lesions in man. (1/259)

Descending bulbospinal pathways that employ specific neurotransmitter substances are known to be capable of modulating segmental reflex activity in the experimental animal. To determine whether this might also occur in man correlations have been sought between the activity in spinal reflex pathways and the lumbar cerebrospinal fluid (CSF) concentrations of 5-hydroxyindolacetic acid (5-HIAA), 3 methoxy-4-hydroxyphenylglycol (MHPG), and homovanillic acid (HVA) in 12 patients with complete or virtually complete spinal lesions. The concentrations of 5-HIAA and MHPG in lumbar CSF ARE REDUCED AFTER COMPLETE OR VIRTUALLY COMPLETE SPINAL LESIONS IN MAN. This may occur within 18 days of the lesion. MHPG concentrations appear to be inversely related to the level of the lesion. The HVA concentration in lumbar CSF is reduced when there is obstruction of the CSF pathways. No relationship could be demonstrated between the concentrations of 5-HIAA or MHPG in lumbar CSF and the activity in the spinal monosynaptic pathway (estimated from the proportion of the motoneurone pool activated by the Achilles tendon reflex or H reflex) or the activity of a spinal inhibitory mechanism (estimated by the degree of vibratory inhibition of the monosynaptic reflex). Patients with a tonic vibration reflex (TVR) tended to have higher MHPG levels. There appeared to be an association between low CSF HVA and enhanced vibratory inhibition of the monosynaptic reflex in the nine patients whose spinal lesions were complete.  (+info)

'Oblongata' crises in tabes dorsalis. (2/259)

A patient in the pre-ataxic stage of tabes dorsalis suffered from gastric crises, but in addition had numerous episodes of apnoea and coma which in the older literature have been described as 'oblongata crises'--the presumption being that the crises are due to a brain stem disturbance.  (+info)

Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues. (3/259)

We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta) polymerization. These proteins are also present in cerebrospinal fluid, but at low concentrations having little or no effect on Abeta. Thirteen proteins representing more than 90% of the protein content in plasma and cerebrospinal fluid were studied. Quantitatively, albumin was the most important protein, representing 60% of the total amyloid inhibitory activity, followed by alpha1-antitrypsin and immunoglobulins A and G. Albumin suppressed amyloid formation by binding to the oligomeric or polymeric Abeta, blocking a further addition of peptide. This effect was also observed when the incorporation of labeled Abeta into genuine beta-amyloid in tissue section was studied. The Abeta and the anti-diabetic drug tolbutamide apparently bind to the same site on albumin. Tolbutamide displaces Abeta from albumin, increasing its free concentration and enhancing amyloid formation. The present results suggest that several endogenous proteins are negative regulators of amyloid formation. Plasma contains at least 300 times more amyloid inhibitory activity than cerebrospinal fluid. These findings may provide one explanation as to why beta-amyloid deposits are not found in peripheral tissues but are only found in the central nervous system. Moreover, the data suggest that some drugs that display an affinity for albumin may enhance beta-amyloid formation and promote the development of Alzheimer's disease.  (+info)

Quinupristin/dalfopristin attenuates the inflammatory response and reduces the concentration of neuron-specific enolase in the cerebrospinal fluid of rabbits with experimental Streptococcus pneumoniae meningitis. (4/259)

The inflammatory response following initiation of antibiotic therapy and parameters of neuronal damage were compared during intravenous treatment with quinupristin/dalfopristin (100 mg/kg as either a short or a continuous infusion) and ceftriaxone (10 mg/kg/h) in a rabbit model of Streptococcus pneumoniae meningitis. With both modes of administration, quinupristin/dalfopristin was less bactericidal than ceftriaxone. However, the concentration of proinflammatory cell wall components (lipoteichoic acid (LTA) and teichoic acid (TA)) and the activity of tumour necrosis factor (TNF) in cerebrospinal fluid (CSF) were significantly lower in the two quinupristin/dalfopristin groups than in ceftriaxone-treated rabbits. The median LTA/TA concentrations (25th/75th percentiles) were as follows: (i) 14 h after infection: 133 (72/155) ng/mL for continuous infusion of quinupristin/dalfopristin and 193 (91/308) ng/mL for short duration infusion, compared with 455 (274/2042) ng/mL for ceftriaxone (P = 0.002 and 0.02 respectively); (ii) 17 h after infection: 116 (60/368) ng/mL for continuous infusion of quinupristin/dalfopristin and 117 (41/247) ng/mL for short duration infusion, compared with 694 (156/2173) ng/mL for ceftriaxone (P = 0.04 and 0.03 respectively). Fourteen hours after infection the median TNF activity (25th/75th percentiles) was 0.2 (0.1/1.9) U/mL for continuous infusion of quinupristin/dalfopristin and 0.1 (0.01/3.5) U/mL for short duration infusion, compared with 30 (4.6/180) U/mL for ceftriaxone (P = 0.02 for each comparison); 17 h after infection the TNF activity was 2.8 (0.2/11) U/mL (continuous infusion of quinupristin/dalfopristin) and 0.1 (0.04/6.1) U/mL (short duration infusion), compared with 48.6 (18/169) U/mL for ceftriaxone (P = 0.002 and 0.001). The concentration of neuron-specific enolase (NSE) 24 h after infection was significantly lower in animals treated with quinupristin/dalfopristin: 4.6 (3.3/5.7) microg/L (continuous infusion) and 3.6 (2.9/4.7) microg/L (short duration infusion) than in those treated with ceftriaxone (17.7 (8.8/78.2) microg/L) (P = 0.03 and 0.009 respectively). In conclusion, antibiotic treatment with quinupristin/dalfopristin attenuated the inflammatory response within the subarachnoid space after initiation of antibiotic therapy. The concentration of NSE in the CSF, taken as a measure of neuronal damage, was lower in quinupristin/dalfopristin-treated rabbits than in ceftriaxone-treated rabbits.  (+info)

A 20-year epidemiological study of pneumococcal meningitis. (5/259)

We conducted a retrospective analysis of 55 community-acquired Streptococcus pneumoniae meningitis illnesses in Huntington, West Virginia, from 1978 to 1997. Fourteen (36.8%) of 38 adults and 2 (11.8%) of 17 children died. Serotypes 6, 23, 3, and 18 accounted for 20 (41.7%) of 48 strains available for serotyping. Of 40 strains available for antimicrobial susceptibility testing, 1 serotype 19 and 1 serotype 23 strain showed intermediate resistance and a second serotype 23 strain showed high resistance to penicillin; all three patients survived. The case-fatality rates among adults who received penicillin alone, gentamicin in combination, or vancomycin and cephalosporin together were 57.1%, 55.5%, and 60%, respectively, and among those who received chloramphenicol or a third-generation cephalosporin, they were 11.1% or nil, respectively. No child died who received chloramphenicol or vancomycin. Two (33%) of 6 children died who received a third-generation cephalosporin; both were critically ill when initially treated. No child and one adult had received pneumococcal vaccine prior to becoming ill.  (+info)

High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitis. (6/259)

It was shown in children that serum procalcitonin was the best marker to use to differentiate bacterial from viral meningitis. To evaluate procalcitonin in the diagnosis of acute bacterial and viral meningitis, we conducted a prospective study including adult patients who were suspected of having meningitis and who were admitted to an emergency department. Cerebrospinal fluid (CSF) and serum levels of procalcitonin were measured in 105 consecutive patients. The diagnosis of meningitis was based on clinical findings, gram staining, culture, and chemical analysis of CSF. Twenty-three patients had bacterial meningitis, 57 had viral meningitis, and 25 did not have meningitis. Bacteriologic and chemical analysis of CSF did not allow correct differentiation of viral from bacterial meningitis. On the other hand, a serum procalcitonin level >0.2 ng/mL had a sensitivity and specificity of up to 100% in the diagnosis of bacterial meningitis. Serum procalcitonin levels seem to be the best marker in differentiating between bacterial and viral meningitis in adults.  (+info)

HLA-DPB1*0501-associated opticospinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies. (7/259)

In order to clarify the relationship between the clinical phenotype and the human leucocyte antigen (HLA) in multiple sclerosis in Asians, 93 Japanese patients with clinically definite multiple sclerosis underwent clinical MRI and HLA-DPB1 gene typing studies. According to a neurological examination, 29 patients were classified as opticospinal multiple sclerosis, 17 as spinal multiple sclerosis and 47 as Western type multiple sclerosis showing the involvement of multiple sites in the CNS including either the cerebrum, cerebellum or brainstem. The opticospinal multiple sclerosis showed a significantly higher age of onset, higher expanded disability status scale scores and higher CSF cell counts and protein content than the Western type multiple sclerosis. On brain and spinal cord MRI, the opticospinal multiple sclerosis showed a significantly lower number of brain lesions, but a higher frequency of gadolinium-enhancement of the optic nerve and a higher frequency of spinal cord atrophy than in Western type multiple sclerosis. The frequency of the HLA-DPB1*0501 allele was found to be significantly greater in opticospinal multiple sclerosis (93%) than in healthy controls (63%, corrected P value = 0.0091 and relative risk = 7.9), but not in Western type multiple sclerosis (66%) or spinal multiple sclerosis (82%). The marked differences in the clinical and MRI findings as well as in the immunogenetic backgrounds between the opticospinal multiple sclerosis and Western-type multiple sclerosis together suggest that HLA-DPB1*0501-associated opticospinal multiple sclerosis is a distinct subtype of multiple sclerosis.  (+info)

Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry. (8/259)

A quick two-step procedure involving liquid phase isoelectric focusing in the Rotofor cell in combination with electroelution in the Mini whole cell gel eluter has been used for purification of proteins from human cerebrospinal fluid (CSF). Fractions, each highly enriched in a single protein band and virtually free of other proteins, were selected for characterization by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOFMS). Six CSF proteins, transferrin, alpha1-acid-glycoprotein, Zn-alpha2-glycoprotein, apolipoprotein A1, apolipoprotein E and beta-trace were identified by MALDI-TOFMS analysis of the tryptic digests. These results demonstrate that the combination of liquid phase IEF and electroelution is a rapid preparative two-dimensional separation which can provide single proteins of high purity, in yields sufficient for characterization by MALDI-TOFMS. Characterization of such brain-specific proteins in CSF will be useful in the investigation of the pathophysiology of different brain disorders.  (+info)

*Hal Huggins

Huggins HA, Levy TE (1998). "Cerebrospinal Fluid Protein Changes in Multiple Sclerosis After Dental Amalgam Removal" (PDF). ... In a paper published in Alternative Medicine Review in 1998, Huggins claimed that changes in cerebrospinal fluid that are ...

*Prostaglandin D2 synthase

... a novel protein from human cerebrospinal fluid". Brain Research. 565 (2): 337-40. doi:10.1016/0006-8993(91)91666-O. PMID ... a protein abundant in human cerebrospinal fluid". Neuroscience Letters. 154 (1-2): 93-5. doi:10.1016/0304-3940(93)90179-O. PMID ... to check whether fluid leaking from the nose or ear contains cerebrospinal fluid. This is important in the assessment of head ... "Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein". Applied and Theoretical ...

*Heart-type fatty acid binding protein

"Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies". ... "Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration". ... Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is ... "Fatty acid-binding protein, heart". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Kleine AH, Glatz JF, Van ...

*Cerebrospinal fluid

"Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins". Science. ... The amount of cerebrospinal fluid varies by size and species. In humans and other mammals, cerebrospinal fluid, produced, ... ISBN 978-1-118-68589-1. Circulation of Cerebrospinal Fluid (CSF) - Interactive Tool Cerebrospinal fluid - course material in ... Cerebrospinal fluid (CSF) is a clear, colorless body fluid found in the brain and spinal cord. It is produced in the choroid ...

*Isobaric labeling

"Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags". Anal. Chem. 80 (8): ... "8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin ... Peptides or proteins are labeled with various chemical groups that are (at least nominally) isobaric, or the same in mass, but ... In a typical bottom-up proteomics workflow, proteins are enzymatically digested by a protease to produce peptides, which are ...

*Meninges

They are responsible for the production of beta-trace protein (prostaglandin D synthase) a major cerebrospinal fluid protein . ... Cerebrospinal fluid is located in the subarachnoid space between the arachnoid mater and the pia mater. The primary function of ... which is filled with cerebrospinal fluid. The dura mater is attached to the skull, whereas in the spinal cord, the dura mater ... Roles as a Cell Marker or in Cerebrospinal Fluid Absorption, Tumorigenesis, and Calcification Process". Journal of Neuroscience ...

*Kearns-Sayre syndrome

... cerebellar ataxia and elevated levels of cerebrospinal fluid protein. Kearns-Sayre syndrome occurs spontaneously in the ... Mutations in these proteins results in impaired energy production by mitochondria. This cellular energy deficit manifests most ... CSF analysis shows an elevated protein level, usually >100 mg/dl, as well as an elevated lactate level. Currently there is no ... Among these, 13 genes encode proteins of the electron transport chain (abbreviated "ETC"), 22 encode transfer RNA (tRNA), and ...

*Neuroglobin

Recent research on Neuroglobin presence confirmed that Human neuroglobin protein in cerebrospinal fluid (CSF). Neuroglobin was ... "Human neuroglobin protein in cerebrospinal fluid". Proteome Science. 3 (1): 2. doi:10.1186/1477-5956-3-2. PMC 554085 . PMID ... It is an intracellular hemoprotein expressed in the central and peripheral nervous system, cerebrospinal fluid, retina and ... Cytoglobin Hemoprotein Hemoglobin Leghemoglobin Myoglobin Cerebrospinal fluid DellaValle B, Hempel C, Kurtzhals JA, Penkowa M ( ...

*IGFBP2

... binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. ... "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an ... "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids". J ... Rajaram S, Baylink DJ, Mohan S (1997). "Insulin-like growth factor-binding proteins in serum and other biological fluids: ...

*Huntington's disease

"Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients". The Journal of Clinical ... Mutant huntingtin was detected and quantified for the first time in cerebrospinal fluid from Huntington's disease mutation- ... Chase, Alex (21 April 2015). "Huntington disease: Cerebrospinal fluid and MRI biomarkers for prodromal HD". Nature Reviews ... The huntingtin protein interacts with over 100 other proteins, and appears to have multiple biological functions. The behavior ...

*Clostridium botulinum

Collection of cerebrospinal fluid (CSF) protein and blood assist with the exclusion of Guillan-Barre syndrome and stroke. ... The classification into groups is based on the ability of the organism to digest complex proteins. Studies at the DNA and rRNA ...

*14-3-3 protein

Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. There are ... "Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob ... Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation. ... 14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have ...

*Neonatal sepsis

newborn CSF (Cerebrospinal fluid) screen: showing increased cells and proteins. suggestive history of chorioamnionitis, PROM ( ... and cerebrospinal fluid (CSF) studies and CSF culture, admit the newborn to the hospital, and treat empirically for serious ... In addition to fluid resuscitation and supportive care, a common antibiotic regimen in infants with suspected sepsis is a beta- ...

*CSF albumin

A closely related test, CSF total protein is a measurement used to determine the levels of protein in cerebrospinal fluid. It ... "MedlinePlus Medical Encyclopedia: CSF total protein". Seehusen DA, Reeves MM, Fomin DA (September 2003). "Cerebrospinal fluid ... CSF albumin is a measurement used to determine the levels of albumin in cerebrospinal fluid. ... "Changes with aging of steroidal levels in the cerebrospinal fluid of women". Maturitas. 33 (1): 71-80. doi:10.1016/S0378-5122( ...

*Tandem mass tag

"Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags". Anal. Chem. 80 (8): ... Intuitively, the trust associated with a protein measurement depends on the similarity of ratios from different peptides and ... 2003). "Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS". Anal ... and a protein reactive group (R). The chemical structures of all the tags are identical but each contains isotopes substituted ...

*Pandy's test

Proteins in the cerebrospinal fluid, normally albumin and globulin are present in the ratio of 8 to 1. Increase in protein ... Pandy's test (or Pandy's reaction) is done on the CSF (cerebrospinal fluid) to detect the elevated levels of proteins (mainly ... A bluish-white streak of precipitated proteins is seen. The degree of turbidity depends on the amount of protein in the CSF. It ... The CSF sample is normal i.e. with normal protein contents. Please note that the normal CSF protein is also obtained in several ...

*AZGP1

Davidsson P, Nilsson CL (2000). "Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two- ... Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene. This gene expresses a soluble protein that ... a soluble fat-depleting factor related to major histocompatibility complex proteins". J. Biol. Chem. 276 (37): 35008-13. doi: ...

*TREM2

Del Bono N, Dente FL, Del Bono L (2008). "Identification of a novel soluble TREM-2 protein in the cerebrospinal fluid in ... Soluble TREM2 has been detected in human cerebrospinal fluid (CSF), where it was found to be elevated in CSF of patients with ... "Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation". ... Triggering receptor expressed on myeloid cells 2 also known as TREM-2 is a protein that in humans is encoded by the TREM2 gene ...

*Pathophysiology of multiple sclerosis

2008). "Multiple sclerosis-related proteins identified in cerebrospinal fluid by advanced mass spectrometry". Proteomics. 8 (8 ... "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". ... cartilage acidic protein), tetranectin (a plasminogen-binding protein), SPARC-like protein (a calcium binding cell signalling ... Oct 2014). "The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to ...

*Behçet's disease

Cerebrospinal fluid (CSF) analysis may demonstrate elevated protein level with or without pleocytosis. Imaging including ... Heat shock proteins (HSPs) are present in some bacteria and serve as a "danger signal" to the immune system. However, some HSPs ... An association with the GIMAP ("GTPase of the immunity-associated protein") family of genes on the long arm of chromosome 7 ( ... Direskeneli, H. (2013). "Innate and Adaptive Responses to Heat Shock Proteins in Behcet's Disease". Genetics Research ...

*Human herpesvirus 6

Levels of myelin basic protein were elevated in his cerebrospinal fluid, suggesting that demyelination was occurring. This link ... The human P53 protein functions as a tumor suppressor. Individuals who do not properly produce this protein experience a higher ... The molecular mimicry hypothesis, in which T cells are essentially confusing an HHV-6 viral protein with myelin basic protein, ... Myelin basic protein (MBP) regularly exchanges phosphate groups with the environment, and its ability to do so has implications ...

*Froin's syndrome

... - coexistence of xanthochromia, high protein level and marked coagulation of cerebrospinal fluid (CSF). It is ...

*Glioblastoma

... leading to high protein content in the cerebrospinal fluid (CSF) (> 100 mg/dL), as well as an occasional pleocytosis of 10 to ...

*Lymphocytic pleocytosis

... hearing and vision loss and were found to have higher concentrations of lymphocytes and proteins in their cerebrospinal fluid. ... Lymphocytic pleocytosis is an abnormal increase in the amount of lymphocytes in the cerebrospinal fluid (CSF). It is usually ... Increases in lymphocyte count are often accompanied by an increase in cerebrospinal protein concentrations in addition to ... Lumbar Puncture (LP) Interpretation of Cerebrospinal Fluid at eMedicine Skelly, Michael J; Burger, Andrew A; Adekola, ...

*Itraconazole

... is over 99% protein-bound and has virtually no penetration into cerebrospinal fluid. Therefore, it should not be ... Recently, itraconazole was found to contribute to the formation of nanofibers in certain simulated intestinal fluids. These ... "Growth of Itraconazole Nanofibers in Supersaturated Simulated Intestinal Fluid". Molecular Pharmaceutics. 7 (3): 905-13. doi: ...

*Avid Radiopharmaceuticals

Other diagnostic tools, such as analysis of cerebrospinal fluid, magnetic resonance imaging scans looking for brain shrinkage ... would cross the blood-brain barrier and attach itself to amyloid protein deposits in the brain. Avid raised $500,000 from ... by other pharmaceutical firms as a means of determining the ability of the drugs to reduce the buildup of amyloid protein in ...
Cerebral Thrombosis, Cerebrospinal Fluid Protein Increased, Poor Outcome Symptom Checker: Possible causes include Subarachnoid Hemorrhage, Cerebral Thrombosis, Stroke. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Cerebrospinal Fluid Protein Increased & Intracerebral Hematoma Symptom Checker: Possible causes include Cerebral Hemorrhage & Cerebral Thrombosis & Stroke. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Classic chronic inflammatory demyelinating polyneuropathy (CIDP) is characterized by the occurrence of symmetrical weakness in both proximal and distal muscles that progressively increases for more than two months (setting this condition apart from the Guillain-Barré syndrome, which is self-limited). The condition is associated with impaired sensation, absent or diminished tendon reflexes, an elevated cerebrospinal fluid protein level, demyelinating nerve-conduction studies, and signs of demyelination in nerve-biopsy specimens. The course can be relapsing or chronic and progressive, the former being much more common in young adults ...
Free Online Library: Bilateral cerebellopontine angle metastatic melanoma: a case report.(Disease/Disorder overview) by Ear, Nose and Throat Journal; Health, general Accountants Blood glucose Blood sugar Cancer metastasis Care and treatment Development and progression Prognosis Cerebrospinal fluid proteins Certified public accountants Medical research Medicine, Experimental Melanoma Metastasis Radiotherapy
In a normal healthy patient CSF is clear, colorless, and contains only a few cells. It can have up to five leukocytes per cmm but should not have any erythrocytes present. The leukocytes most often seen are lymphocytes and monocytes. Because the brain requires proteins and glucose for nourishment it is normal to find these molecules in CSF. A normal sample of CSF has a total protein level around 15-45 mg/mL and a glucose level around 40-70 mg/mL. These values can change in response to a disruption in the blood-brain barrier. There are several instances where CSF protein levels will be increased. Mild increases can occur due to inflammation caused by diseases such as meningitis, encephalitis, presence of tumors, hemorrhage, and stroke. Bacterial meningitis will cause a much larger increase in CSF protein concentration. Severe increases in protein concentration can be found in patients with Guillain-Barre syndrome. For patients with multiple sclerosis the increase in protein concentration is mild ...
Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies. Among multiple existing approaches to interpreting measured protein levels, the Reiber diagram is particularly robust with respect to physiologic inter-individual variability, as it uses multiple subject-specific anchoring values. Beyond reliable identification of abnormal protein levels, the Reiber diagram has the potential to elucidate their pathophysiologic origin. In particular, both reduction of CSF drainage from the cranio-spinal space as well as blood-CNS barrier dysfunction have been suggested ρas possible causes of increased concentration of blood-derived proteins. However, there is disagreement on which of the two is the true cause.. Methods ...
Values of Magnetic Resonance Imaging and Cerebrospinal fluid analysis in the diagnosis of Central NervousSystem associated infectious diseases
We performed two independent studies, discovery and validation, to identify AD markers by profiling proteins in human plasma using the aptamer-based SOMAscanTM technology. Specifically, we aimed to identify markers with better performance than the best-performing CSF markers, tau and Ab42, to discriminate AD from non-demented controls. We constructed a 5-protein classifier in the discovery study and demonstrated that the plasma protein classifier allowed the prediction of AD with 100.0% sensitivity, 80.0% specificity, and 90.0% accuracy in an independent validation study, matching or outperforming CSF tau and Ab42. Individual-matched plasma and CSF samples were obtained at the same visit, allowing direct comparison of diagnostic performance between the plasma protein classifier and CSF protein biomarkers. Moreover, the classifier also correctly predicted mild cognitive impairment (MCI), an early pre-dementia state of the disease, with 96.7% sensitivity, 80.0% specificity, and 92.5% accuracy. ...
EPSTEIN, J.A. Essentials of Diagnosis Lumbosacral Disk Back pain aggravated by motion, and pain radiating down the back of the leg and aggravated by coughing or straining. Sciatic nerve painful to pressure and stretch (straight-leg raising). CSF protein may be elevated; myelograms reveal characteristic defect. Cervical Disk
cP450 MS data versus sP450 radiometric data at 1/5 total protein concentration. See the article by Weaver et al. on page 955 of this issue. ...
Shunts are the standard treatment for hydrocephalus, but they are prone to complications, with up to 16% of shunts requiring revision within one month.17 Some consider that a high CSF protein plays a part in shunt failure,1-6 but recent work has invalidated most theories on possible mechanisms.7-9However, the possibility of protein deposition obstructing the shunt lumen has not yet been investigated.. In 1963 Scarff stated that "...cerebrospinal fluid is laden with protein and minerals, which are gradually deposited as particulate matter on the inner surfaces of the tubes and valves, contributing to their obstruction or malfunction".6 This statement, from a clinical review, was made without any supporting evidence, but is still accepted by many. Furthermore, as far as can be determined, no attempt has been made to verify or refute the statement.. The only material present in sufficient quantities to occlude the catheters in this series was choroid plexus. Several authors, analysing material ...
Guillain-Barré syndrome (GBS) is characterised by a classical triad of progressive motor weakness, areflexia and elevated cerebrospinal fluid (CSF) protein without pleocytosis.1 Landry published the first modern description of an illness likely to be acute inflammatory demyelinating polyneuropathy (AIDP) in 1859. Osler provided a more detailed account of what he called acute febrile polyneuritis in 1892. In 1916, Guillain, Barré and Strohl further enlarged the clinical description and first reported the characteristic CSF finding, albuminocytological dissociation (that is, elevation of CSF protein with normal CSF cell count).1. We consider the pathophysiology, diagnostic features, assessment, differential diagnoses and management of GBS. This article will also outline the spectrum of the disease. Most of the research on GBS has been based on adult or predominantly adult studies, so there has been unavoidable extrapolation with respect to GBS in children and young people ...
ABSTRACT: Tuberculosis (TB) carries a high morbidity and mortality, however, its diagnosis can be difficult due to low concentration of bacteria in the cerebrospinal fluid (CSF). Although increased CSF protein, decreased CSF glucose; cerebrospinal fluid (CSF) pleocytosis with mononuclear cells predominance are commonly used to diagnose TB infection, they show inconsistent results. Objectives: To analyze the relationship between several characteristics of the CSF and TB meningitis. Methods: This is an observational research, with a cross sectional design, 27 patients with TB meningitis and or meningoencephalitis with Thwaites diagnostic score ≤ 4 obtained from mecidal records. The definitive diagnosis of TB meningitis was made using the Ziehl Neelsen (ZN) staining and or culture TB, or polymerase chain reaction (PCR) amplification with the target in IS6110, Ziehl-Neelsen staining (ZN) culture method. Characteristics of CSF including increased CSF protein, decreased CSF glucose, cerebrospinal ...
Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
TY - JOUR. T1 - How to handle adsorption of cerebrospinal fluid amyloid β (1-42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ42/Aβ40 ratio. AU - Willemse, Eline. AU - van Uffelen, Kees. AU - Brix, Britta. AU - Engelborghs, Sebastiaan. AU - Vanderstichele, Hugo. AU - Teunissen, Charlotte. PY - 2017/8/1. Y1 - 2017/8/1. N2 - Introduction We aimed to investigate factors defining amyloid β (1-42) (Aβ1-42) adsorption during preanalytical workup of cerebrospinal fluid (CSF). Methods CSF was transferred to new tubes ≤4 times. Variables tested were different polypropylene tube brands, volumes, CSF Aβ1-42 concentrations, incubation times, pipettes, vortex intensities, and other CSF proteins, including hyperphosphorylated tau and Interleukin 1 Receptor Accessory Protein (IL-1RAcP). An enquiry assessed the number of transfers in current practice. Results In diagnostic practice, the number of transfers varied between 1 and 3. Every tube transfer ...
OBJECTIVES. Isoelectric focusing (IEF) is a laboratory technique that allows to separate proteic molecules based on their isoelectric point. This technique, applied to cerebro spinal fluid (CSF) IgG, has been used to study human neurological diseases. CSF IgG concentration increases either with neurological diseases that alter the blood-brain barrier (BBB), increasing IgG access from the blood, or with neurological diseases that determine local activation of the immune system with intrathecal synthesis (IS) of IgG. To date, no studies on IEF of canine CSF have been performed. The purpose of this study was to investigate IgG patterns of distribution in CSF of dogs with several neurological diseases and to compare these data to CSF total protein concentrations for each dog.. MATERIALS. Twenty-four dogs have been included in the study. Sixteen dogs had spinal cord compression (SCC), 3 dogs had brain neoplasia (BN), 2 dogs had cerebellar abiotrophy (CA), 1 dog had steroid-responsive meningitis ...
Comparative changes in monthly blood urea nitrogen, total protein concentrations, and body condition scores of Nguni cows and heifers raised on sweetveld
Cerebrospinal fluid (CSF) analysis is commonly referred to as a spinal tap. During this procedure, a small volume of spinal fluid is collected and submitted to a laboratory for analysis of protein content, white blood cell count and determination of the types of white blood cells that are present. Spinal fluid is very sensitive for identifying disease in the central nervous system, but is not very specific to which disease is present as there is a great deal of overlap between diseases.. CSF analysis is used in conjunction with other tests, including MRI, to narrow the list of possible neurological diseases. In some cases, CSF will provide a definitive diagnosis, such as lymphoma, a type of cancer. Tests for several infectious diseases (Figure 2) can be performed on spinal fluid if needed.. In animals this procedure is performed under general anesthesia. While a person may be asked to lie still for a procedure, an animal cannot. However, since the animals are under anesthesia, there is no pain ...
The 26 people with HIV had a median age of 37 (interquartile range [IQR] 31 to 44) and had HIV infection for a median of 136 days (IQR 59.5 to 178.3). The HIV groups median CD4 count was significantly lower than that of the 20 HIV-negative controls, but four values were significantly higher in the HIV group: CD8 count, CSF WBC, CSF neopterin, and plasma neopterin. CSF protein and CSF/plasma albumin ratio were nonsignificantly higher in the HIV group ...
A 51-year-old presented with subacute headache, right facial weakness and numbness. MRIB showed widespread enhancing hemispheric lesions with a focal lesion of the right CN VII nucleus. CSF protein 0.84 g/l; CSF lymphs 10×106/l. A diagnosis of ADEM was made and symptoms resolved soon after steroids. Five months later, he developed a progressively ataxic gait, leg weakness and dysarthria. Second CSF showed 12×106/l lymphs and protein of 0.95 g/l. CSF cytology showed nonspecific, active, chronic inflammation. MRIB revealed minimally enhancing lesions within the internal capsules, lentiform nuclei extending into the cerebral peduncles. Notably, the CN VII nuclear lesion completely disappeared. MRS suggested an infiltrative process and a diagnosis of grade 2 astrocytoma was made following brain biopsy. It has been proposed that dexamethasone modifies disruptions to the BBB and previous authors report resolution of radiological enhancement in glioma following steroids. We found two cases of high ...
KIRIM US A MESSAGE. We didnt put all products on website. If you cant find the product youre looking for, please contact us for more information.. ...
MRX information about active ingredients, pharmaceutical forms and doses by Mahdeen Mediceuticals, MRX indications, usages and related health products lists
CSF analysis is an important diagnostic tool in the investigation of neurological patients, but there are limitations to it. The cell count and protein level of the CSF can be thought of as a CNS analogue of the CBC and serum protein level. Abnormalities in the colour, cellularity and protein level of the CSF are strongly indicative of neurological disease and often contribute to the diagnosis, but are non-specific and only occasionally provide a definitive diagnosis by themselves. CNS diseases also do not always cause alterations in the CSF - abnormalities depend on the location and extent of the lesion. Prior treatment with corticosteroids may interfere with CSF and reduce the white blood cell count and percentage of neutrophils. CSF should ideally be processed (or preserved) within 30 minutes after collection because the cells deteriorate rapidly due to little protein content.. CSF collection should be performed prior to myelography, since contrast agents may induce meningeal irritation and ...
Launched on 2nd September 2015, the new state of the art Fitzpatrick Referrals animal hospital based in Guildford is the first of its kind in Europe and aims to change the way cancer is treated in companion animals.. Whilst this building will impress and contain the latest equipment, it is the team of people inside that makes it truly outstanding.. We have brought together world class medical and surgical oncologists with extensive experience in advanced radiation procedures, and the best nursing teams in order to gain a better understanding of animal cancer and to use that knowledge to deliver the very best treatment to animals.. We aim to deliver all of the options to all of the animals all of the time, and we aim to work with our human colleagues to better inform the treatment of cancer for everyone.. With Fitzpatrick Referrals Orthopaedics and Neurology, we will also be the only centre in Europe offering custom-designed 3D-printed limb and joint salvage prostheses.. ...
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Detailed dosage guidelines and administration information for QS Plus (benzethonium chloride). Includes dose adjustments, warnings and precautions.
The Lowry protein assay is a biochemical assay for determining the total level of protein in a solution. The total protein concentration is exhibited by a color change of the sample solution in proportion to protein concentration, which can then be measured using colorimetric techniques.. ...
Also known as: WHO CSF, THE CSF OF, IN CSF, Csf, CsF., CsF, Cs-F, CSf, CSF., CSF+, CSF WAS, CSF The, CSF It, CSF BE, CSF, CS+F. When, CS+F, C.s.f, C.S.F. This, C.S.F. The, C.S.F. In, C.S.F. As, C.S.F., C.S.F, C. S. F., C-SF ...
csf - MedHelps csf Center for Information, Symptoms, Resources, Treatments and Tools for csf. Find csf information, treatments for csf and csf symptoms.
腰椎穿刺需要使患者側臥,採用局部麻醉,將針頭扎入硬膜囊(脊椎附近的囊腔)以收集腦脊液(CSF)。一旦獲得腦脊液,則其「開啟壓力」可使用壓力計來衡量。該壓力通常在6和18 ...
CAS:121-54-0 Benzethonium chloride, US $ 20 - 30 / Kilogram, 121-54-0, 2-phenylethyliuM chloride, C27H42ClNO2.Source from Jinan Boss Chemical Industry Co., Ltd. on Alibaba.com.
To the Editor: Acute encephalitis/encephalopathy associated with human metapneumovirus (HMPV) has been documented in children (1-3). Recently, Fok et al. (4) described an encephalitis case in an adult but were unable to test cerebrospinal fluid (CSF) for HMPV. Following authors recommendations, we performed diagnostic testing on the CSF of an adult with HMPV-associated encephalitis.. A previously healthy 61-year-old man came to our institution with headache and seizures 5 days after onset of an influenza-like illness. A lumbar puncture on admission revealed pleocytosis (36 cells/µL) and a mononuclear predominance of 98%. Results of magnetic resonance imaging and computed tomography of the head and chest radiography on admission were inconclusive. The patient was treated in the intensive care unit for possible viral and bacterial meningoencephalitis. Although results of routine CSF-workup for infectious causes were unremarkable, total CSF protein level was elevated at 1.39 g/L (reference range ...
An 18-year-old woman presented with a progressively worsening headache, photophobia feverishness and vomiting. Three weeks previously she had returned to the UK from a trip to Peru. At presentation, she had clinical signs of meningism. On admission, blood tests showed a mild lymphopenia, with a normal C reactive protein and white cell count. Chest X-ray and CT of the head were normal. Cerebrospinal fluid (CSF) microscopy was normal. CSF protein and glucose were in the normal range. MRI of the head and cerebral angiography were also normal. Subsequent molecular testing of CSF detected enterovirus RNA by reverse transcriptase PCR. The patients clinical syndrome correlated with her virological diagnosis and no other cause of her symptoms was found. Her symptoms were self-limiting and improved with supportive management. This case illustrates an important example of viral central nervous system infection presenting clinically as meningitis but with normal CSF microscopy.. ...
BACKGROUND: A neuroinflammatory response is suggested to play an important role in delirium, a common complication in older hospitalized patients. We examined whether hip fracture patients who develop postoperative delirium have a different proteome in cerebrospinal fluid (CSF) prior to surgery. METHODS: Patients (≥ 75 years) were admitted for hip ... read more fracture surgery. CSF was collected during spinal anaesthesia; proteins were separated using gel electrophoresis and identified with mass spectrometry. We compared the proteome of patients with and without postoperative delirium. Findings were validated in an independent, comparable cohort using immuno-assays. RESULTS: In the derivation cohort 53 patients were included, 35.8% developed postoperative delirium. We identified differences in levels of eight CSF proteins between patients with and without subsequent delirium: complement factor C3, contactin-1, fibulin-1 and I-beta-1,3-N-acetylglucosaminyltransferase were significantly lower ...
TY - JOUR. T1 - Endothelin in human cerebrospinal fluid. AU - Shirakami, G.. AU - Nakao, K.. AU - Saito, Y.. AU - Magaribuchi, T.. AU - Nagata, H.. AU - Jougasaki, M.. AU - Mukoyama, M.. AU - Arai, H.. AU - Hosoda, K.. AU - Suga, S.. AU - Ogawa, Yoshihiro. AU - Mori, K.. AU - Imura, H.. PY - 1990/12/1. Y1 - 1990/12/1. UR - http://www.scopus.com/inward/record.url?scp=0025651382&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0025651382&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0025651382. VL - 11. SP - 111. EP - 116. JO - Therapeutic Research. JF - Therapeutic Research. SN - 0289-8020. IS - 12. ER - ...
Viral meningitides correspond to a relatively common and self-limited type of CNS infection clinically diagnosed based on the cerebrospinal fluid analysis and proportionally more frequent in young children than adults. Enteroviruses represent now...
The aim of this study is to investigate the long-term effects of the initial spinal cord (SC) involvement in MS patients. In this retrospective, single-center study, 824 patients with definite MS were screened. A total of 348 patients were excluded for ambiguous documentation of the initial relapse, pediatric onset, diagnosis of primary progressive disease, irregular assessments or visits causing doubt on the onset of progression time, and clinical follow-up duration less than 12 months. Eventually, 476 MS patients were included. Data regarding the demographics, initial symptoms, the degree of recovery from the initial relapse, neuroimaging, cerebrospinal fluid analysis, long-term disability, and progression were collected from the medical registry. The mean duration of follow-up was 7.49 ± 5.30 years. The percentage of patients entering the progressive disease course was 23.3 in the whole group. A total of 157 patients (33.0%) had SC involvement during the first clinical relapse. These ...
Conceptual, diagnostic, and technical aspects of urinalysis; fecal, gastric, urinary stone, synovial fluid, seminal fluid, and cerebrospinal fluid analysis; and pregnancy testing. A chapter on the microscope and microscopy. Both established and newer tests and applications are discussed. Adequately illustrated, with color figures on urinalysis. ...
Total protein concentration, preferably in 24-hour urine, aids in the detection of proteinuria. Proteinuria may be caused by renal impairment, systemic overload, or postrenal diseases. As well as 24 hour urine excretion of protein, some clinicians may request a protein : creatinine ratio (PCR ...
Neuroinfections presents 35 subjects, each with a different neurologic infectious or inflammatory disorder. A short vignette provides salient clinical symptoms and signs, laboratory studies, spinal fluid and imaging findings for each patient. A highly focused discussion leads the reader to the final diagnosis. Important features of the history, neurologic examination, findings on CSF and imaging are emphasized.
Neuroinfections presents 35 subjects, each with a different neurologic infectious or inflammatory disorder. A short vignette provides salient clinical symptoms and signs, laboratory studies, spinal fluid and imaging findings for each patient. A highly focused discussion leads the reader to the final diagnosis. Important features of the history, neurologic examination, findings on CSF and imaging are emphasized.
Description of disease CSF total protein. Treatment CSF total protein. Symptoms and causes CSF total protein Prophylaxis CSF total protein
1) Benzethonium chloride and benzalkonium chloride do not exist naturally in grapefruit seeds, or in a truly natural extract of grapefruit seeds.. 2) It is not plausible that the benzethonium chloride or benzalkonium chloride could be formed during the manufacturing process in the high concentrations found in commercial GSE. The logical conclusion is that they are added. 3) The manufacturers of Citricidal have claimed that the researchers that have identified benzethonium chloride in their product are mistaken. If you believe that multiple independent universities using a variety of sophisticated analyses can all be wrong, and all mistakenly identify exactly the same chemical, then I have a bridge in Brooklyn I can sell you :) 4) The Material Safety Data Sheet (MSDS) for Citricidal lists it as "Diphenol hydroxybenzene". This is completely misleading (and a potential safety hazard) as neither benzethonium chloride nor benzalkonium chloride can be described this way. Neither is it an accurate or ...
OBJECTIVE: We evaluated the diagnostic value of cerebrospinal fluid oligoclonal bands in individuals less than 18 years of age.. METHODS: In a nationwide population-based setting, we retrieved data on 2055 childrens oligoclonal band examination, including concordant cerebrospinal fluid biomarkers, during 1994 to 2017. Case ascertainment was by review of medical records and diagnostic codes. We used Fishers exact test to explore distribution differences of oligoclonal band positivity in acquired demyelinating syndromes (ADS) before and after age 12 years and calculated the sensitivity, specificity, positive predictive value, and negative predictive value of oligoclonal bands to distinguish ADS from the other diagnostic groups.. RESULTS: Median age at oligoclonal band examination was 15.2 years (range = 1.8 to 18.0), and 10% had presence of cerebrospinal fluid oligoclonal bands. Oligoclonal band positivity was the highest in ADS (52%), but it was age dependent: 21% in children with ADS before ...
Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have not yet been fully explored. Using a robust automated MS-based proteomic biomarker discovery workflow, we measured cerebrospinal fluid (CSF) proteomes to explore their association with well-established markers of core AD pathology. Cross-sectional analysis was performed on CSF collected from 120 older community-dwelling adults with normal (n = 48) or impaired cognition (n = 72). LC-MS quantified hundreds of proteins in the CSF. CSF concentrations of β-amyloid 1-42 (Aβ1-42), tau, and tau phosphorylated at threonine 181 (P-tau181) were determined with immunoassays. First, we explored proteins relevant to biomarker-defined AD. Then, correlation analysis of CSF proteins with CSF markers of amyloid pathology, neuronal injury, and tau hyperphosphorylation (i.e., Aβ1-42
A combination of pyrimethamine and sulfadiazine plus folinic acid should be administered for 1 year. Steroids are indicated in the presence of infalmmatory lesions such as chorioretinitis involving macula, CSF protein above 2 g/dl at birth or a generalized infection ...
The content in this episode was vetted and approved by Mike Rubenstein.. REFERENCES. Frederiks JA and Koehler PJ. The first lumbar puncture. J Hist Neurosci. 1997;6:147-53.. Seehusen DA, Reeves MM and Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician. 2003;68:1103-8.. Shah KH and Edlow JA. Distinguishing traumatic lumbar puncture from true subarachnoid hemorrhage. J Emerg Med. 2002;23:67-74.. Deisenhammer F, Bartos A, Egg R, Gilhus NE, Giovannoni G, Rauer S, Sellebjerg F and Force ET. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2006;13:913-22.. Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Hausler M, Nau R, Saraya T, Wada H, Goto H, de Martino M, Ueno M, Brown WD, Terborg C and Gilden DH. The varicella zoster virus ...
With colleagues Mark Mintun, M.D., professor of radiology, and David Holtzman, M.D., the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology, Fagan studied a group of 24 people that included individuals diagnosed with very mild and mild Alzheimer s disease, and cognitively normal subjects. As expected, in patients with cognitive impairments, believed to be attributable to Alzheimer s disease, researchers found low CSF levels of amyloid beta 42 (A-beta 42), the principal ingredient of the brain plaques that are characteristic of Alzheimer s disease. In the same individuals, brain scans with a new imaging agent that reveals the presence of amyloid plaques in the brain were positive. What scientists didn t anticipate was that three cognitively normal subjects would have both low CSF levels of A-beta 42 and positive results from the brain scans. Fagan stressed that although this aspect of their findings was very intriguing, it doesn t prove that the three normal ...
1. One- and two-dimensional (correlated shift spectroscopy) high resolution proton n.m.r. spectra of human cerebrospinal fluid (CSF) are reported. The merits of water suppression by freeze drying or irradiation, and spectral simplification by spin-echo methods, are discussed. 2. Well-resolved resonances for a range of low molecular weight metabolites such as lactate, 3-d-hydroxybutyrate, alanine, acetate, citrate, glucose, valine and formate were observed. Resonances for glutamine were observed only from freeze dried samples. Concentrations determined by n.m.r. were in reasonable agreement with those from conventional methods. 3. The n.m.r. spectra of CSF were related to the clinical conditions of the subjects. No resonances for citrate were present in spectra of CSF from subjects (three infants) with bacterial meningitis; high lactate and lowered glucose levels were observed. Strong resonances for glucose and glycine were observed for mildly diabetic subjects. Both the aromatic and the ...
Special Note 1.2: Processing and handling of CSF for analysis - please remember endotoxin is ubiquitous and can change expression of all mediators being assayed. Endotoxin free precautions should be taken for handling of all procedures (sterile precautions and using endotoxin free solutions should suffice ...
Sample Processing is to collect target protein. The processing shall be done as gently as possible as protein denatures or degrades easily. It is also very important to store processed sample, especially avoiding repeated free-thaw cycles. Processed sample can be sub-packed and sealed. Expiry Time: a week at 4 degree; a month at -20 degree; two months at -80 degree. Just put sample in room until its temperature reaches room temperature before using the sample. It is forbidden to heat the sample to melt the sample.. Collect sample and then centrifuge it at 10000rpm for 10 minutes at 4 degree. Then collect supernatant and store it at -80 degree, avoiding repeated free-thaw cycles.. ...
Introduction and purpose. The cerebrospinal fluid contains many biologically active substances, which have a broad influence on different points of application in the organism. We performed the research of the influence of cerebrospinal fluid on the rats lungs (in the connection with the studies, provided in our department and devoted to influence of xenogenic cerebrospinal fluid (XCSF) on the organism of rats). Materials and methods. The investigation was performed on 84 Wistar rats of both sexes, which were divided into the experimental and control groups. The experiment was performed on impuberal (group 1), puberal (group 2) and aged rats (group 3). The duration of the experiment was 7 (for the groups 1 and 2), 30 (for all groups) and 90 days (for the groups 2 and 3). The rats of the experimental group got XCSF at the dose 0.002 ml/g three times with the interval of 2 days (for 7-day experiment) or ten times (for 30- and 90-day experiments). The control group received 0.9 % NaCl using the ...
The AlphaLISA® immunoassay kit for human Aβ40 enables the detection and quantitation of human Aβ40 in human cerebrospinal fluid and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows negligible cross-reactivity with other forms of Amyloid beta (i.e. Aβ1-38 and Aβ1-42).
Results: In 31 out 56 MSers the highly increased CSF levels of κ monomers and dimers were demonstrated. In 18 MSers, the increased κ-FLC levels were accompanied by highly elevated λ dimers. Five MSers showed no significant elevation in κ-FLC, but they displayed abnormally high λ dimer levels. The intensity of the immunoreactive FLC bands was measured to account for κ and λ monomer and dimer levels and their ratios in the CSF and serum. Combined usage of different FLC parameters allowed the determination of the appropriate FLC threshold values to diagnose MS. The developed method showed higher sensitivity and specificity (96% and 90%, respectively), as compared to those of the conventional OCB test (82% and 70%, respectively). ...
A cerebrospinal fluid (CSF) culture is a laboratory test to look for bacteria, fungi, and viruses in the fluid that moves in the space around the spinal cord. CSF protects the brain and spinal cord from injury.
Researchers discover that an elevated volume of subarachnoid cerebrospinal fluid could be associated with a higher risk of developing autism.
... / M. Ogundare; S. Theofilopoulos; A. Lockhart; L.J. Hall; E. Arenas; J. Sjövall; A.G. Brenton; Y. Wang; W.J. Griffiths ...
The CSF circulation comprises not only a directed flow of CSF, but in addition a pulsatile to and fro movement throughout the entire brain with local fl..
World Chronicle delivers an unprejudiced coverage of latest news and events from around the world while keeping fake news at bay ...
Synonyms for blood-cerebrospinal fluid barrier in Free Thesaurus. Antonyms for blood-cerebrospinal fluid barrier. 1 word related to blood-brain barrier: barrier. What are synonyms for blood-cerebrospinal fluid barrier?
Nonetheless, certain immunologic features of NMO are shared with this novel MOG Ig-associated opticospinal inflammatory disease. Whereas oligoclonal IgG bands (OBs) are identified in the CSF of most patients with MS, they are detected in only a minority of patients with NMO.33 As in NMO, OBs were rarely detected in patients with MOG Ig-associated opticospinal inflammatory disease.3 It is recognized that NMO IgG is mostly produced outside the CNS, as studies have demonstrated that its concentration in serum is many times higher than in CSF.34 Thus, both the identification of MOG-specific antibodies in the serum and the relative absence of CSF OBs suggest that, like in NMO, the MOG-specific humoral immune process occurs predominantly outside the CNS in these patients. Of interest, histologic analysis of NMO lesions in experimental animal studies suggests that the unique cellular composition of NMO lesions may reflect the complement-fixing properties of NMO IgG, an IgG1 subtype.35 While presumably ...
SELDI-TOF MS is a system that enables rapid protein profiling, identification, and characterization from crude biological samples by selective capture of subclasses of proteins with specific physical or biochemical characteristics. The molecular weight as well as the quantity of individual proteins absorbed on each ProteinChip array is then directly assessed by a time-of-flight mass spectrometer, generating quantitative protein mass profiles for individual CSF specimens. Comparative protein expression profile analysis highlights any CSF protein species which are aberrantly expressed in the CSF of encephalopathy patients compared to febrile seizure subjects.. Before analysis of the CSF, experiments were designed to optimize the ProteinChip array conditions for the SELDI-TOF MS proteomics tests. Three chip types, Q10 (strong anion exchange surface), CM10 (weak cation exchange surface), and IMAC30 (metal binding surface) (Bio-Rad), were tested along with a variety of binding/washing conditions, ...
Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression.. Reliable biomarkers could empower such trials and guide the timing for initiation of future DMTs.. Neurofilament light (NFL) and tau, which are cerebrospinal fluid markers of neuronal death, have been implicated as markers of disease progression. Increased levels of the inflammatory marker YKL-40 have also been reported in HD.. The aim was to validate and compare the above biomarker candidates by targeted analyses, while explorative liquid chromatography-mass spectrometry (LC-MS) was used to identify new candidates. Clinically well-characterized HD patients, premanifest gene expansion carriers (pGECs), and controls were enrolled from Uppsala University Hospital in Sweden.. In contrast to tau, NFL ...
Streptococcal meningitis symptoms, causes, diagnosis, and treatment information for Streptococcal meningitis (Bacterial meningitis) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
Multiple sclerosis, which is the most common cause of chronic neurological disability in young adults, is an inflammatory, demyelinating, and neurodegenerative disease of the CNS, which leads to the formation of multiple foci of demyelinated lesions in the white matter. The diagnosis is based currently on magnetic resonance image and evidence of dissemination in time and space. However, this could be facilitated if biomarkers were available to rule out other disorders with similar symptoms as well as to avoid cerebrospinal fluid analysis, which requires an invasive collection. Additionally, the molecular mechanisms of the disease are not completely elucidated, especially those related to the neurodegenerative aspects of the disease. The identification of biomarker candidates and molecular mechanisms of multiple sclerosis may be approached by proteomics. In the last 10 years, proteomic techniques have been applied in different biological samples (CNS tissue, cerebrospinal fluid, and blood) from ...
By means of radial immunodiffusion, immunoglobulins A, G, M and albumin were determined in serum and unconcentrated cerebrospinal fluid from 182 controls and 141 patients. Concentrations in cerebrospinal fluid and serum of patients did not correlate, not even in those groups whose elevated immunoglobulin and albumin concentrations in cerebrospinal fluid resulted from damage to the blood-cerebrospinal fluid barrier, as in inflammatory diseases and neoplastic processes of the central nervous system or of the meninges.--Concentrations of immunoglobulins in cerebrospinal fluid should therefore be evaluated independently of the serum concentrations. Cerebrospinal fluid and serum constitute samples from two separate compartments which are capable of independent immune reactions.
Recent advances in magnetic resonance imaging have made it possible to visualize and quantify flow of cerebrospinal fluid (CSF) in the brain. The net flow of CSF through the cerebral aqueduct was used to measure CSF production in six normal volunteers at different times during a 24-h period. CSF production varied greatly both intra- and interindividually. The average CSF production in each time interval showed a clear tendency to circadian variation, with a minimum production 30% of maximum values (12 +/- 7 ml/h) approximately 1800 h and a nightly peak production approximately 0200 h of 42 +/- 2 ml/h. The total CSF production during the whole 24-h period, calculated as an average of all measurements, was 650 ml for the whole group and 630 ml for repeated measurements in each time interval in one of the volunteers ...
Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patients blood serum, or cerebrospinal fluid (CSF) is analyzed. Two methods of analysis are possible: (a) protein electrophoresis, a method of analyzing the composition of fluids, also known as "agarose gel electrophoresis/Coomassie Blue staining", and (b) the combination of isoelectric focusing/silver staining. The latter is more sensitive. For the analysis of cerebrospinal fluid, a patient has a lumbar puncture performed, which collects some of his or her cerebrospinal fluid. The blood serum can be gained from a clotted blood sample. Normally it is assumed that all the proteins that appear in the CSF, but are not present in the serum, are produced intrathecally (inside the CNS). Therefore, it is normal to subtract bands in serum from bands in CSF when investigating CNS diseases. OCBs are especially important for multiple sclerosis. In MS, normally only OCBs made of immunoglobulin G antibodies are considered, though ...
The neurology section provides a broad range of diagnostic and therapeutic services for all species. Expertise in neurologic assessment is combined with special medical imaging (MRI and multi-slice CT scan), electrodiagnostics (electromyography, nerve conduction velocity, repetitive nerve stimulation and brainstem auditory evoked potentials), clinical pathology (cerebrospinal fluid analysis) in pursuit of the most rapid and complete diagnosis. Commonly seen problems include lesions of the spinal column, brain disease including seizures, vestibular disease and metabolic diseases. WSU has leading edge neurosurgical capabilities for all levels of the nervous system, i.e. peripheral nerves, spinal cord, and brain. The neurology service also has access to a complete veterinary rehabilitation facility including a technician who is certified in veterinary rehabilitation. This facility is utilized by neurologic patients who have recently had spinal or brain surgery and also those who have a variety of ...
For the protein assay, H295R and ACC-T36 cells were plated and transfected as described by França et al. 17. The cells were lysed 72 h post-transfection in RIPA buffer containing protease and phosphatase inhibitors (Sigma Aldrich Gmbh, Steinheim, Germany). The total protein concentration was determined using the Bradford assay. Total protein lysates (30 µg) were resolved by 12% SDS-PAGE and gels were blotted onto nitrocellulose membranes after electrophoresis. Non-specific binding sites were blocked for 2 h with 0.1% bovine serum albumin (BSA) or 5% non-fat dried milk in TBST (TRIS-buffered saline solution containing 1% Tween 20). All washes and antibody incubations were performed using TBST. The following primary antibodies were used: anti-SF-1 (RD Systems Inc., Minneapolis, MN, USA; 1:1000) in blocking buffer (5% non-fat dried milk in TBST) and anti-actin (1:1000) in TRIS-buffered saline containing 1% Tween 20. Proteins were visualized using enhanced chemiluminescence (ECL) detection with ...
Krock E, Millecamps M, Anderson KM, Srivastava A, Reihsen TE, Hari P, Sun YR, Jang SH, Wilcox GL, Belani KG, Beebe DS, Ouellet J, Pinto MR, Kehl LJ, Haglund L, Stone LS. Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine. 2019 Apr 29. pii: S2352-3964(19)30271-3. [link ...
Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be supported by the analysis of Tau and 14-3-3 in the cerebrospinal fluid (CSF). In this short report, we report about a retrospective analysis performed on 2,296 routinely collected CSF samples, and 44 samples with a ratio of phosphoTau181/Tau 100,000 AU/mL, while 10 out of 12 suspected CJD samples with 14-3-3 CSF levels between 50,000-100,000 AU/mL were CJD positive. All samples with 14-3-3 levels between 15,000 and 50,000 AU/mL were not CJD cases but disorders with complex neuropathology. In conclusion, our data suggests that in CSF samples with a phospho-Tau-181/Tau ratio Pharmacology 2017;100:243- ...
An investigation into methods for determining the total protein content of cerebrospinal fluid: implications for universal guidelines ...
Dear editor: We would like to present a modified method for cerebrospinal fluid collection in anesthetized rat. This method is easy and applicable in many laboratories interested by research on cellular and molecular effects of CSF on different pathways.
Researchers have found a link between increased levels of cerebrospinal fluid in the brains of infants and a higher risk for autism spectrum disorder.
Pris: 633,-. E-bok, 2012. Leveres direkte via nedlastning . Kjøp boken Serous Cavity Fluid and Cerebrospinal Fluid Cytopathology av Syed Z. Ali, Edmund S. Cibas (ISBN 9781461417767) hos Adlibris.com. Fri frakt.
For survival, the emergence of oligoclonal bands after multiple myeloma treatment is less important than achieving complete remission. Crossref DOI link: https://doi.org/10.1016/J.BJHH.2017.05.010 Published: 2017-10. Update policy: https://doi.org/10.1016/ELSEVIER_CM_POLICY. ...
Eesti Teadusinfosüsteem koondab informatsiooni teadus- ja arendusasutuste, teadlaste, teadusprojektide ning erinevate teadustegevuste tulemuste kohta.
Penyakit Herniasi Otak - Herniasi otak merupakan kondisi ketika jaringan otak dan cairan otak (cerebrospinal fluid) bergeser dari posisi normalnya. Kondisi ini dipicu oleh pembengkakan otak akibat cedera kepala, stroke, [more…] ...
ANN ARBOR, Mich. - Parents of infants who survive bacterial meningitis caused by group B Streptococcus might have to live with the effects of the disease on their children long after theyre discharged from the hospital.. A new study in the journal Pediatrics finds that even though mortality rates of children infected with GBS meningitis have decreased in the past 25 years, just under half of children who survive the disease will suffer impairment as a result of the disease.. "These bacteria can quickly cause significant damage to the developing infant brain very quickly despite the infants having received excellent medical care," says Morven S. Edwards, M.D., professor of Pediatrics at Baylor College of Medicine and a co-author on the paper. "This is a potentially devastating illness and we still have a large percentage of infants who have poor outcomes after the infection.". According to the CDC, 25 percent of pregnant women carry GBS. It is routine for these women to receive antibiotics ...
Modified Lights criteria are widely used to categorise pleural fluids as either exudates or transudates. These criteria include fluid/serum ratios and therefore require a blood sample. It is not clear whether analysis of pleural fluid alone would alter pleural fluid categorisation in routine clinical practice. In this study, pleural fluids were categorised using cut-off values for pleural fluid protein (⩾30 g/l) and lactate dehydrogenase (,0.45 of upper limit of the serum reference interval) recommended as providing optimal discrimination between transudates and exudates. The resultant categorisations were compared with those produced by application of modified Lights criteria. 77 pleural fluid specimens were included for analysis. Using modified Lights criteria, 32 fluids were categorised as transudates and 45 as exudates. Applying the pleural fluid cut-off values as outlined above, 26 fluids were categorised as transudates and 51 as exudates. Agreement was observed in 71/77 or 92.2% (95% ...
Clinical diagnosis of Guillain Barre Syndrome begins with complaints of symmetric weakness, and absence of deep tendon reflexes on examination. The clinical diagnosis is confirmed by cerebrospinal fluid analysis and nerve conduction studies. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
We investigated the prevalence of dengue in patients with suspected viral meningitis/meningoencephalitis in a dengue-endemic area. Cerebrospinal fluid analysis showed positive results and a 6.74× greater likelihood of identifying positive fluid in patients who died. Our findings support testing patients with neurologic manifestations for the virus in dengue-endemic areas.
FORTI, Francisco and LIMONGI, João Carlos Papaterra. Juvenile hereditary chorea: study of a family with recessive pattern. Arq. Neuro-Psiquiatr. [online]. 1994, vol.52, n.3, pp.402-405. ISSN 0004-282X. https://doi.org/10.1590/S0004-282X1994000300019.. Report of a family in which the parents are consanguineous and healthy and 4 of their 8 children began with involuntary choreic movements at ages 10 to 14. In all cases the clinical manifestations remained stable troughout the 5-year period of observation. There have been no clinical deterioration and intellectual functions were found to be intact. All patients were submitted to neurologic examination, neuropsychological testing, CT-scan, cerebrospinal fluid analysis, eletroencephalogram , serum copper and ceruloplasmin among other blood tests. These cases were diagnosed as having "juvenile hereditary chorea" from the typical clinical manifestations and after exclusion of other known causes of chorea. Relevant clinical aspects and possible ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The role of autoreactive antibodies in MS has received intense attention since the discovery of oligoclonal immunoglobulin (Ig) bands in the spinal fluid of the majority (,95%) of MSers. However, many questions remain. We still do not know whether the production of Ig in the brain of MSers is an epiphenomenon of CNS autoimmunity, resulting from growth factor-driven expansion of long-lived B cells (the cells that make antibodies) in the meningeal* compartment or whether Ig production from antigen-driven proliferation of B-cell clones contributes to CNS pathology. CSF Ig from oligoclonal bands is produced by CSF B lineage cells and primarily recognizes epitopes of multiple neurotropic viruses and Epstein-Barr virus antigens. However, antimyelin antibodies also occur in the serum and CSF of patients with MS. ...
Various laboratories have reported differing success rates in their ability to detect intrathecal synthesis of antibody when comparing the index of [Formula: see text] with electrophoretic analysis. We selected 44 patients in the borderline area of minimal and/or equivocal abnormality by IgG index. Electrophoretic analysis (on polyacrylamide gels for oligoclonal gamma globulin pattern) of parallel specimens was performed at the same time. The number of samples giving a normal index but showing oligoclonal bands varied between 34% and 43% depending on the cut-off point. The views about normal barrier functions underlying such indices are discussed with particular reference to the pathophysiology of the blood-CSF barrier.. ...
Calmodulin-like skin protein is downregulated in human cerebrospinal fluids of Alzheimer fs disease patients with apolipoprotein E4; a pilot study using postmortem samples. Neurological Research. 2017 Sep;39(9):767-772. doi: 10.1080/01616412.2017.1335458. Epub 2017 Jun 7 ...
The James Bourne Ayer Papers, 1788-1960, include the professional and personal records resulting from JBAs work as an academic physician and neurologist at HMS and MGH. The collection contains correspondence, memoranda, notes and writings that document his administrative, teaching, and research activities, including his research on human cerebrospinal fluid. JBAs correspondence with colleagues, staff meeting minutes, reports, writings and notes record his research and administrative responsibilities. JBAs professional activities are documented his correspondence with and about medical societies, particularly the American Neurological Association of which JBA was the president ...
Influx of nonactivated T lymphocytes into the cerebrospinal fluid during relapse of multiple sclerosis.: T lymphocytes were analyzed in the cerebrospinal fluid
The only specific procedures unique to this protocol is the collection of an additional 3ml or less of cerebrospinal fluid from a lumbar puncture already being performed and the collection of clinical information from the patients medical records. Lumbar puncture may be either a research procedure or a standard of care procedure, depending upon the reason for initiating the puncture. We will aliquot the additional fluid into a separate storage container and it will be maintained in the laboratory of Dr. Heiman-Patterson at -70 degrees. Clinical information including age, medical and neurological history, laboratory data, and pathologic information where indicated will be abstracted from the patient chart. All specimens and corresponding clinical information will be labeled with an identification number and sorted by diagnosis. There will be no patient identifying information kept with the specimens. The CSF sample may be used for studies performed by researchers at Drexel University College of ...
Alzheimer disease biomarker testing in cerebrospinal fluid : a method to harmonize assay platforms in the absence of an absolute reference standard ...
Dan-solo (dotoole at NOSPAM!tcd.ie) wrote: , ,In article ,7t9fd4$4cq at news.acns.nwu.edu,, MJ Lee ,mjlee at nwu.edu, wrote: , , , ,Can blood cells pass through BBB and enter the cerebrospinal fluid? , ,thanks! , , , . , Blood resident lymphocytes can break through the BBB during a Multiple , Sclerosis relapse, where they are directed to inflammation sites by IL-10. , I dont think this normally ever happens though. As far as I know, , macrophages can do the same thing. Id imagine that any oxygen required by , the neuron is provided via the astrocyte, as there are no RBCs in CSF. But there are RBCs in the brain capillary bed. Kal ...
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Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) [email protected] ...
An eight-year-old, neutered male labrador was presented with recent recurrent vestibular episodes. MRI was consistent with multiple lacunar ischaemic infarcts in the thalamus and medulla oblongata. The imaging diagnosis was supported by a markedly elevated D-dimer concentration. Despite a comprehensive diagnostic workup (including fine needle cytology of cutaneous and subcutaneous nodules, complete bloodwork, urinalysis, thoracic and abdominal imaging, cerebrospinal fluid analysis, serial blood pressure measurements, echocardiography, electrocardiography and brainstem auditory evoked response testing), no underlying cause was found. After a partial response to 2 mg/kg clopidogrel once a day and 1 mg/kg prednisolone once a day, the dog acutely deteriorated and repeated MRI of the brain revealed an intra-axial haemorrhagic mass. Euthanasia was elected and postmortem examination revealed the presence of an intravascular null-cell lymphoma, exclusively in the central nervous system. Intravascular ...
TY - CONF. T1 - Characterization of Cerebrospinal Fluid by GCxGC-TOFMS. AU - Mattila, Ismo. AU - Hartonen, Minna. AU - Ruskeepää, Anna-Liisa. AU - Oresic, Matej. AU - Hyötyläinen, Tuija. N1 - Project code: 70554; 22655; 23167. PY - 2013. Y1 - 2013. N2 - Analysis of human cerebrospinal fluid (CSF) offers an important insight into the central nervous system disorders, since its molecular composition depends on brain metabolism. As CSF sampling is an intensive procedure, blood-based markers would be more suitable for large-scale screening of the biomarkers. Matching serum and CSF samples were collected from 53 individuals, and analyzed with GCxGC-TOFMS.. AB - Analysis of human cerebrospinal fluid (CSF) offers an important insight into the central nervous system disorders, since its molecular composition depends on brain metabolism. As CSF sampling is an intensive procedure, blood-based markers would be more suitable for large-scale screening of the biomarkers. Matching serum and CSF samples ...
The main purpose of this trial is to test if mortality of childhood bacterial meningitis can be reduced by slow, continuous infusion of cefotaxime initially, instead of the traditional bolus administration four times daily (qid), combined with high-dose paracetamol orally, when both treatments are executed for the first 4 days. The series will be collected at Hospital Pediátrico David Bernardino, Luanda, Angola. The recruitment of patients begins, the conditions permitting, in early 2012. The criteria for patient participation is a child at the age of 2 months to 15 years who presents with the symptoms and signs suggestive of bacterial meningitis, for whom a lumbar puncture is performed, and the cerebrospinal fluid analysis suggests bacterial meningitis.
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - Pipeline Review, H2 2016, provides an overview of the Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) pipeline landscape. The report provides comprehensive information on the therapeutics under development for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.. Browse more detail information about Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) at: http://www.absolutereports.com/chronic-inflammatory-demyelinating-polyneuropathy-cidp-pipeline-review-h2-2016-10315974. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved ...

Cerebrospinal Fluid Protein Increased & Intracerebral Hematoma<...Cerebrospinal Fluid Protein Increased & Intracerebral Hematoma<...

Cerebrospinal Fluid Protein Increased & Intracerebral Hematoma Symptom Checker: Possible causes include Cerebral Hemorrhage & ... 136 Possible Causes for Cerebrospinal Fluid Protein Increased, Intracerebral Hematoma * Cerebral Hemorrhage ... Differential diagnoses, possible causes and diseases for Cerebrospinal Fluid Protein Increased, Intracerebral Hematoma listed ... protein may be elevated and there may be an increase in the number of mononuclear cells.[epilepsy.com] Cerebrospinal fluid (CSF ...
more infohttps://www.symptoma.com/en/ddx/cerebrospinal-fluid-protein-increased+intracerebral-hematoma

Cerebral Thrombosis & Cerebrospinal Fluid Protein Increased & Poor Outcome<...Cerebral Thrombosis & Cerebrospinal Fluid Protein Increased & Poor Outcome<...

Cerebrospinal Fluid Protein Increased, Poor Outcome Symptom Checker: Possible causes include Subarachnoid Hemorrhage, Cerebral ... 155 Possible Causes for Cerebral Thrombosis, Cerebrospinal Fluid Protein Increased, Poor Outcome * Subarachnoid Hemorrhage ... Differential diagnoses, possible causes and diseases for Cerebral Thrombosis, Cerebrospinal Fluid Protein Increased, Poor ... slight shortening of T1 occurs due to the increased protein and new cellular content within cerebrospinal fluid (CSF).[ ...
more infohttps://www.symptoma.com/en/ddx/cerebral-thrombosis+cerebrospinal-fluid-protein-increased+poor-outcome

CSF total protein: MedlinePlus Medical EncyclopediaCSF total protein: MedlinePlus Medical Encyclopedia

CSF is a clear fluid that is in the space around the spinal cord and brain. ... CSF total protein is a test to determine the amount of protein in cerebrospinal fluid (CSF). ... CSF total protein is a test to determine the amount of protein in cerebrospinal fluid (CSF). CSF is a clear fluid that is in ... Spinal puncture and cerebrospinal fluid examination. In: Roberts JR, Custalow CB, Thomsen TW, eds. Roberts and Hedges Clinical ...
more infohttps://medlineplus.gov/ency/article/003628.htm

Correction of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar PuncturesCorrection of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar Punctures

For every 1000 cerebrospinal fluid red blood cells/mm3, cerebrospinal (cerebrospinal fluid) protein increased 1.1 mg/dL (95% ...
more infohttps://insights.ovid.com/pidj/201710000/00006454-201710000-00023

Cerebrospinal Fluid Proteins and Spinal Anesthesia in Obstetrics | Anesthesiology | ASA PublicationsCerebrospinal Fluid Proteins and Spinal Anesthesia in Obstetrics | Anesthesiology | ASA Publications

Cerebrospinal Fluid Proteins and Spinal Anesthesia in Obstetrics You will receive an email whenever this article is corrected, ... Cerebrospinal Fluid Proteins and Spinal Anesthesia in Obstetrics. Anesthesiology 5 1965, Vol.26, 340-343. doi: ... Gertie F. Marx, Louis R. Orkin; Cerebrospinal Fluid Proteins and Spinal Anesthesia in Obstetrics. Anesthesiology 1965;26(3):340 ...
more infohttp://anesthesiology.pubs.asahq.org/article.aspx?articleid=1965817

Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimers diseaseDevelopment of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimer's disease

... protein blood level, protein cerebrospinal fluid level, protein microarray, suspension bead array, very elderly National ... Detailed knowledge of protein changes in cerebrospinal fluid (CSF) across healthy and diseased individuals would provide a ... Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimers disease. ... protein S100B, SPARC like protein 1, unclassified drug, vascular cell adhesion protein 1, adult, aged, Alzheimer disease, ...
more infohttp://kth.diva-portal.org/smash/record.jsf?pid=diva2:1337494

Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins...Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins...

Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins ... Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins ... Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins ... Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/15550170?dopt=Abstract

Analysis of Cerebrospinal Fluid for Proteins and Sugars | SpringerLinkAnalysis of Cerebrospinal Fluid for Proteins and Sugars | SpringerLink

... is a clear and colorless fluid that occurs between the layers pia mater and arachnoid mater covering central nervous system. ... Kumar V., Gill K.D. (2018) Analysis of Cerebrospinal Fluid for Proteins and Sugars. In: Basic Concepts in Clinical Biochemistry ... Cerebrospinal fluid (CSF) is a clear and colorless fluid that occurs between the layers pia mater and arachnoid mater covering ... The composition of CSF is same to that of brain extracellular fluid. The ionic composition for CSF is similar to the plasma for ...
more infohttps://link.springer.com/chapter/10.1007/978-981-10-8186-6_34

Quantitative analysis of human cerebrospinal fluid proteins using a combination of cysteine tagging and amine-reactive isobaric...Quantitative analysis of human cerebrospinal fluid proteins using a combination of cysteine tagging and amine-reactive isobaric...

It was then applied to human cerebrospinal fluid (CSF) from post-mortem and ante-mortem samples. These studies confirmed the ... As many proteins of biological interest are of low abundance, numerous analytical methodologies have been developed to reduce ... The model protein mixture analysis showed high precision and accuracy of the quantification with coefficients of variation and ... The strategy was first evaluated on a model protein mixture with increasing concentrations to assess the specificity of the ...
more infohttps://www.semanticscholar.org/paper/Quantitative-analysis-of-human-cerebrospinal-fluid-Giron-Dayon/e17d6aa382cbd0834920594829ac52c83eda7139

tau protein in cerebrospinal fluid | SpringerLinktau protein in cerebrospinal fluid | SpringerLink

Cerebrospinal fluid (CSF) biochemical markers for Alzheimer disease (AD) would be of great value to improve the clinical ... Protein analyses in cerebrospinal fluid: I. Influence of concentration gradients for proteins on cerebrospinal fluid/serum ... Alzheimer disease (AD) biochemical markers cerebrospinal fluid (CSF) tau protein This is a preview of subscription content, log ... tau protein in cerebrospinal fluid. A biochemical marker for axonal degeneration in Alzheimer disease? ...
more infohttps://link.springer.com/article/10.1007%2FBF02815140

JCI -
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntingtons disease patientsJCI - Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients

Effect of sample collection tubes on cerebrospinal fluid concentrations of tau proteins and amyloid β peptides. Clin Chem. 2006 ... Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntingtons disease patients. Edward J. Wild,1 Roberto ... BACKGROUND: Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and ... Quantification of disease-associated proteins in human cerebrospinal fluid (CSF) is increasingly valuable for diagnosis, ...
more infohttps://www.jci.org/articles/view/80743

Get PDF - Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein...Get PDF - Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein...

Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in ... Cerebrospinal fluid biomarkers of beta-amyloid metabolism in multiple sclerosis. 2013. Immunophenotyping of cerebrospinal fluid ... Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in ... Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in ...
more infohttps://eurekamag.com/research/036/496/036496039.php

Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia.  - PubMed - NCBICerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia. - PubMed - NCBI

Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia.. Landqvist Waldö M1, ... Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia ... Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia ... is thought to reflect neuronal and axonal death when appearing in the cerebrospinal fluid (CSF). NFL has been shown to be ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23718879?dopt=Abstract

Proteins of the Cerebrospinal Fluid by E. J. Thompson (9780123693693)Proteins of the Cerebrospinal Fluid by E. J. Thompson (9780123693693)

Buy Proteins of the Cerebrospinal Fluid by E. J. Thompson (9780123693693) from Boomerang Books, Australias Online Independent ... Proteins of the Cerebrospinal Fluid by E. J. Thompson. The analysis of the protein content of the Cerebrospinal Fluid (CSF) is ... Book Reviews - Proteins of the Cerebrospinal Fluid by E. J. Thompson. » Have you read this book? Wed like to know what you ... Proteins of the Cerebrospinal Fluid. Analysis & Interpretation in the Diagnosis and Treatment of Neurological Disease 2nd ed.. ...
more infohttps://www.boomerangbooks.com.au/proteins-of-the-cerebrospinal-fluid/e-j-thompson/book_9780123693693.htm

Recherche uO Research: Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in...Recherche uO Research: Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in...

Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year ... Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year ... Abstract Background To better characterize the value of cerebrospinal fluid (CSF) proteins as diagnostic markers in a clinical ... tau and S100B proteins are useful diagnostic markers of sCJD even in a low-prevalence clinical population. CSF tau showed ...
more infohttps://ruor.uottawa.ca/handle/10393/33578

Development of affinity columns for the removal of high-abundance proteins in cerebrospinal fluidDevelopment of affinity columns for the removal of high-abundance proteins in cerebrospinal fluid

... Ramström, Margareta KTH, ... cerebrospinal fluid). Hence, molecules with specific affinity towards proteins present at high concentration in CSIF were ... Development of affinity columns for the removal of high-abundant proteins in cerebrospinal fluidAvailable from: 2008-03-19 ... Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein ...
more infohttp://kth.diva-portal.org/smash/record.jsf?pid=diva2:13364

Amyloid Beta Protein and Tau in Cerebrospinal Fluid and Plasma as...: Ingenta ConnectAmyloid Beta Protein and Tau in Cerebrospinal Fluid and Plasma as...: Ingenta Connect

Amyloid Beta Protein and Tau in Cerebrospinal Fluid and Plasma as Biomarkers for Dementia: A Review of Recent Literature ... in cerebrospinal fluid (CSF) and plasma as biomarkers for dementia. Recent research focused on the progression of patients with ... Keywords: Alzheimer disease; Amyloid precursor protein; CSF biomarkers; Lewy Body Dementia; mild cognitive impairment (MCI) ... This review addresses recent developments in amyloid β (Aβ), total tau (t-tau) and phosporylated tau (p-tau) protein analysis, ...
more infohttps://www.ingentaconnect.com/content/ben/ccp/2008/00000003/00000002/art00007

Obstructive Sleep Apnea Decreases Central Nervous System-Derived Proteins in the Cerebrospinal FluidObstructive Sleep Apnea Decreases Central Nervous System-Derived Proteins in the Cerebrospinal Fluid

... ... SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. ... Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect ... the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154-159 ...
more infohttps://insights.ovid.com/anon/201607000/00000668-201607000-00014

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development | PNASPrion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development | PNAS

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development. Sonia M. Vallabh, Chloe ... Cerebrospinal fluid prion protein levels thus may usefully serve as a pharmacodynamic biomarker. This biomarker may open new ... Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development ... Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development ...
more infohttps://www.pnas.org/content/116/16/7793.short?rss=1

RePub, Erasmus University Repository:
  Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A...RePub, Erasmus University Repository: Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A...

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis. ... Importance: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions ... Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis. JAMA ... using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC. ...
more infohttps://repub.eur.nl/pub/117374

Frontiers | Differential Protein Profiling of Cerebrospinal Fluid in Piglets with Severe Meningoencephalitis Caused by...Frontiers | Differential Protein Profiling of Cerebrospinal Fluid in Piglets with Severe Meningoencephalitis Caused by...

A total of 813 differential proteins, including 52 up-regulated proteins and 761 down-regulated proteins, were found in the CSF ... A total of 813 differential proteins, including 52 up-regulated proteins and 761 down-regulated proteins, were found in the CSF ... To find the key molecules in cerebrospinal fluid (CSF) needed for the pathogenesis, a SS2 meningoencephalitic pig model and a ... Key words: Streptococcus suis, Meningoencephalitis, Blood-CSF barrier, Cerebrospinal fluid, Proteomics ...
more infohttps://www.frontiersin.org/articles/10.3389/fcimb.2018.00035/full

Cerebrospinal Fluid Levels of Amyloid Precursor Protein Are Associated with Ventricular Size in Post-Hemorrhagic Hydrocephalus...Cerebrospinal Fluid Levels of Amyloid Precursor Protein Are Associated with Ventricular Size in Post-Hemorrhagic Hydrocephalus...

We previously observed PHH-associated elevations in cerebrospinal fluid (CSF) amyloid precursor protein (APP), neural cell ... The results from this study suggest that CSF APP and related proteins at once hold promise as biomarkers of PHH and provide ... Methods CSF levels of APP, L1CAM, NCAM-1, and total protein (TP) were measured in 12 preterm infants undergoing PHH treatment. ... adhesion molecule-L1 (L1CAM), neural cell adhesion molecule-1 (NCAM-1), and other protein mediators of neurodevelopment. ...
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115045

Frontiers | Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging | Frontiers in...Frontiers | Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging | Frontiers in...

... with age in cerebrospinal fluid (CSF) samples from healthy subjects. Lamp2 consists of three isoforms, lamp2a, 2b, and 2c, all ... with age in cerebrospinal fluid (CSF) samples from healthy subjects. Lamp2 consists of three isoforms, lamp2a, 2b, and 2c, all ... The primary objective of this study was to examine the association of a major autophagy protein, lysosome-associated membrane ... The primary objective of this study was to examine the association of a major autophagy protein, lysosome-associated membrane ...
more infohttps://www.frontiersin.org/articles/10.3389/fnagi.2018.00130/full

Total tau protein immunoreactivity in lumbar cerebrospinal fluid of patients with Alzheimers disease. | Journal of Neurology,...Total tau protein immunoreactivity in lumbar cerebrospinal fluid of patients with Alzheimer's disease. | Journal of Neurology,...

Total tau protein immunoreactivity in lumbar cerebrospinal fluid of patients with Alzheimers disease. ... Total tau protein immunoreactivity in lumbar cerebrospinal fluid of patients with Alzheimers disease. ...
more infohttps://jnnp.bmj.com/content/60/2/237.2?ijkey=fb5c6a4d3169c0984f1cb2dc489dcaef4831ebe5&keytype2=tf_ipsecsha

Characterization of Nitrotyrosine-Modified Proteins in Cerebrospinal Fluid | Clinical Proteomics | Full TextCharacterization of Nitrotyrosine-Modified Proteins in Cerebrospinal Fluid | Clinical Proteomics | Full Text

... employed proteomics-based experimental approaches to investigate nitrotyrosine-modified proteins in pooled cerebrospinal fluid ... Tyrosine nitration alters protein structure and function, affects biological half-life, and potentially prevents the ... To identify specific nitrotyrosine-modified proteins in the CSF of individuals diagnosed with HAND, affinity purification and ... the neuronal damage observed in individuals diagnosed with HAND to increased nitrotyrosine modification of neuronal proteins. ...
more infohttps://clinicalproteomicsjournal.biomedcentral.com/articles/10.1007/s12014-010-9041-4
  • [radiologyassistant.nl] Examination of the cerebrospinal fluid (CSF) does not necessarily help in establishing the diagnosis as there are no pathognomonic features. (symptoma.com)
  • [symptoma.com] Study population: Patients are eligible if they have a radiologically proven CVT, a high probability of poor outcome (defined by presence of one or more of the following risk [clinicaltrials.gov] Examination of the cerebrospinal fluid (CSF) does not necessarily help in establishing the diagnosis as there are no pathognomonic features. (symptoma.com)
  • After excluding other factors, five NPSLE patients had severe infection, two patients with status epilepticus or cerebral hemorrhage , and one patient with the liver failure [archivesofrheumatology.org] fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells. (symptoma.com)
  • [merckmanuals.com] fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells. (symptoma.com)
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