Cerebrosides
Neutral glycosphingolipids that contain a monosaccharide, normally glucose or galactose, in 1-ortho-beta-glycosidic linkage with the primary alcohol of an N-acyl sphingoid (ceramide). In plants the monosaccharide is normally glucose and the sphingoid usually phytosphingosine. In animals, the monosaccharide is usually galactose, though this may vary with the tissue and the sphingoid is usually sphingosine or dihydrosphingosine. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1st ed)
Sulfoglycosphingolipids
Glucosylceramides
Cerebroside-Sulfatase
An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside and inorganic sulfate. A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.8.
Chromatography, Thin Layer
Leukodystrophy, Metachromatic
An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.
Termitomyces
Galactosylceramides
N-Acylsphingosine Galactosyltransferase
Chromatography, Gas
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Glycolipids
Schizophyllum
Sphingolipid Activator Proteins
Sphingolipids
A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)
Brain Chemistry
Harderian Gland
Gaucher Disease
An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
Glycosphingolipids
Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)
Myelin Sheath
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Saposins
Fatty Acids
Asterias
Psychosine
Gangliosides
A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997)
Water Loss, Insensible
Lactosylceramides
Ceramides
Sulfotransferases
Sulfuric Acids
Sterculia
Globosides
Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.
Steryl-Sulfatase
Nerve Tissue
Arylsulfatases
Sphingomyelins
Phosphatidylcholines
Cholesterol
Diphenylhexatriene
Lipid Bilayers
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Commerce
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Prescription Fees
Philately
Partial purification and properties of porcine thymus lactosylceramide beta-galactosidase. (1/288)
Porcine thymus lactosylceramide beta-galactosidase was purified by a simple procedure. In the final step of isoelectric focusing the enzyme was separated into two peaks of pI 6.3 (peak I) and 7.0 (peak II), which showed 3,600- and 4,000-fold enhancement of lactosylceramide-hydrolysing activity, respectively. The two peaks had identical mobility on polyacrylamide gel electrophoresis. The apparent molecular weight was 34,000. Neither monosialoganglioside (GM1) nor galactosylceramide was hydrolysed by the purified enzyme fractions. The optimal pH was at 4.6, and sodium taurocholate was essential for the reaction. The apparent Km was 2.3 x 10-5 M. The reaction was stimulated by sodium chloride and linoleic acid, while it was strongly inhibited by Triton X-100 and bovine serum albumin. Galactosylceramide, p-nitrophenyl beta-galactoside, and p-nitrophenol were weak inhibitors. No effects of GM1 and galactose were observed on the hydrolysis of lactosylceramide. (+info)Synthesis and turnover of cerebrosides and phosphatidylserine of myelin and microsomal fractions of adult and developing rat brain. (2/288)
The synthesis and turnover of cerebrosides and phospholipids was followed in microsomal and myelin fractions of developing and adult rat brains after an intracerebral injection of [U-14C]serine. The kinetics of incorporation of radioactivity into microsomal and myelin cerebrosides indicate the possibility of a precursor-product relationship between cerebrosides of these membranes. The specific radioactivity of myelin cerebrosides was corrected for the deposition of newly formed cerebrosides in myelin. Multiphasic curves were obtained for the decline in specific radioactivity of myelin and microsomal cerebrosides, suggesting different cerebroside pools in these membranes. The half-life of the fast turning-over pool of cerebrosides of myelin was 7 and 22 days for the developing and adult rat brain respectively. The half-life of the slowly turning-over pool of myelin cerebrosides was about 145 days for both groups of animals. The half-life of the rapidly turning-over microsomal cerebrosides was calculated to be 20 and 40 h for the developing and adult animals respectively. The half-life of the intermediate and slowly turning-over microsomal cerebrosides was 11 and 60 days respectively, for both groups of animals. The amount of incorporation of radioactivity into microsomal cerebrosides from L-serine was greatly decreased in the adult animals, and greater amounts of the precursor were directed towards the synthesis of phosphatidylserine. In the developing animals, considerable amounts of cerebrosides were synthesized from L-serine, besides phosphatidylserine. The time-course of incorporation indicated that a precursor-product relationship exists between microsomal and myelin phosphatidylserine. The half-life of microsomal phosphatidylserine was calculated to be about 8 h for the fast turning-over pool in both groups of animals. (+info)Divalent cation-mediated interaction between cerebroside sulfate and cerebrosides: an investigation of the effect of structural variations of lipids by electrospray ionization mass spectrometry. (3/288)
Divalent cations mediate a carbohydrate-carbohydrate association between the two major glycolipids, galactosylceramide (GalCer) and its sulfated form, cerebroside sulfate (CBS), of the myelin sheath. We have suggested that interaction between these glycolipids on apposed extracellular surfaces of myelin may be involved in the stability or function of this multilayered structure. A mutant mouse lacking galactolipids because of a disruption in the gene that encodes a galactosyltransferase forms myelin that initially appears relatively normal but is unstable. This myelin contains glucosylceramide (GlcCer) instead of GalCer. To better understand the role of GlcCer in myelin in this mutant, we have compared the ability of divalent cations to complex CBS (galactosyl form) with GlcCer or GalCer in methanol solution by using positive ion electrospray ionization mass spectrometry. Because both the alpha-hydroxylated fatty acid species (HFA) and the nonhydroxylated fatty acid species (NFA) of these lipids occur in myelin, we have also compared the HFA and NFA species. In addition to monomeric Ca2+ complexes of all three lipids and oligomeric Ca2+ complexes of both GalCer and GlcCer, Ca2+ also caused heterotypic complexation of CBS to both GalCer and GlcCer. The heterotypic complexes had the greatest stability of all oligomers formed and survived better at high declustering potentials. Complexes of CBS with GlcCer were less stable than those with GalCer. This was confirmed by using the free sugars and glycosides making up the carbohydrate headgroups of these lipids. HFA species of CBS and GalCer formed more stable complexes than NFA species, but hydroxylation of the fatty acid of GlcCer had no effect. The ability of GlcCer to also complex with CBS, albeit with lower stability, may allow GlcCer to partially compensate for the absence of GalCer in the mouse mutant. (+info)Forssman penta- and tetraglycosylceramide are xenoantigens of ostrich kidney and liver. (4/288)
The heterophile antigens Galalpha1-->3Gal and N-glycolylneuraminic acid are the major obstacle to grafting mammal organs, especially from pig, to man. Lack of expression of these common xenoantigens by birds has raised interest in ostrich as a potential organ donor for xenotransplantation. Glycosphingolipids of ostrich liver and kidney were investigated for their carbohydrate determinants. Both organs were found similar in their glycolipid composition with three major species, mono-, di-, and pentaglycosylceramide. The pentaglycosylceramide was characterized as the Forssman antigen. In both organs, the ceramide portion was highly hydroxylated with prevalence of alpha-hydroxylated fatty acids, C18 phytosphingosine in kidney and C18 sphingosine in liver Forssman glycolipid. These data indicate that hydroxylation of kidney glycosphingolipids, which is found in mammals, has been maintained since the divergence of birds from other vertebrates. Characterization of a minor glycolipid as a Forssman tetraglycosylceramide built on the galabiosylceramide core indicates that the Forssman tetraglycosylceramide also exists in vivo. Its precursors, galactosyl- and galabiosylceramide, were characterized in kidney and liver. The Forssman antigen is the third heterophile antigen against which man raises natural antibodies. Its localization in the vascular endothelium and connective tissue makes ostrich an unpromising organ or cell donor for xenotransplantation to man. (+info)Lipid-dependent targeting of G proteins into rafts. (5/288)
Domains rich in sphingolipids and cholesterol, or rafts, may organize signal transduction complexes at the plasma membrane. Raft lipids are believed to exist in a state similar to the liquid-ordered phase. It has been proposed that proteins with a high affinity for an ordered lipid environment will preferentially partition into rafts (Melkonian, K. A., Ostermeyer, A. G., Chen, J. Z., Roth, M. G., and Brown, D. A. (1999) J. Biol. Chem. 274, 3910-3917). We investigated the possibility that lipid-lipid interactions between lipid-modified proteins and raft lipids mediate targeting of proteins to these domains. G protein monomers or trimers were reconstituted in liposomes, engineered to mimic raft domains. Assay for partitioning of G proteins into rafts was based on Triton X-100 insolubility. Myristoylation and palmitoylation of Galpha(i) were necessary and sufficient for association with liposomes and partitioning into rafts. Strikingly, the amount of fatty-acylated Galpha(i) in rafts was significantly reduced when myristoylated Galpha(i) was thioacylated with cis-unsaturated fatty acids instead of saturated fatty acids such as palmitate. Prenylated betagamma subunits were excluded from rafts, whether reconstituted alone or with fatty-acylated alpha subunits. These results suggest that the structural difference between lipids that modify proteins is one basis for the selectivity of protein targeting to rafts. (+info)Trans interactions between galactosylceramide and cerebroside sulfate across apposed bilayers. (6/288)
The two glycosphingolipids galactosylceramide (GalC) and its sulfated form, cerebroside sulfate (CBS), are present at high concentrations in the multilayered myelin sheath and are involved in carbohydrate-carbohydrate interactions between the lipid headgroups. In order to study the structure of the complex of these two glycolipids by Fourier transform infrared (FTIR) spectroscopy, GalC dispersions were combined with CBS dispersions in the presence and absence of Ca(2+). The FTIR spectra indicated that a strong interaction occurred between these glycolipids even in the absence of Ca(2+). The interaction resulted in dehydration of the sulfate, changes in the intermolecular hydrogen bonding interactions of the sugar and other oxygens, decreased intermolecular hydrogen bonding of the amide C==O of GalC and dehydration of the amide region of one or both of the lipids in the mixture, and disordering of the hydrocarbon chains of both lipids. The spectra also show that Ca(2+) interacts with the sulfate of CBS. Although they do not reveal which other groups of CBS and GalC interact with Ca(2+) or which groups participate in the interaction between the two lipids, they do show that the sulfate is not directly involved in interaction with GalC, since it can still bind to Ca(2+) in the mixture. The interaction between these two lipids could be either a lateral cis interaction in the same bilayer or a trans interaction between apposed bilayers. The type of interaction between the lipids, cis or trans, was investigated using fluorescent and spin-label probes and anti-glycolipid antibodies. The results confirmed a strong interaction between the GalC and the CBS microstructures. They suggested further that this interaction caused the CBS microstructures to be disrupted so that CBS formed a single bilayer around the GalC multilayered microstructures, thus sequestering GalC from the external aqueous phase. Thus the CBS and GalC interacted via a trans interaction across apposed bilayers, which resulted in dehydration of the headgroup and interface region of both lipid bilayers. The strong interaction between these lipids may be involved in stabilization of the myelin sheath. (+info)Dimorphic expression of cerebrosides in the mycopathogen Sporothrix schenckii. (7/288)
Major neutral glycosphingolipid components were extracted from Sporothrix schenckii, a dimorphic fungus exhibiting a hyphal saprophytic phase and a yeast parasitic phase responsible for chronic mycotic infections in mammalian hosts. These components, one from the mycelial form and two from the yeast form, were purified and their structures were elucidated by (1)H nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and tandem ESI-MS/MS. All three were characterized as cerebrosides (monohexosylceramides) containing (4E, 8E)-9-methyl-4,8-sphingadienine as the long-chain base attached to N-2'-hydroxyoctadecanoate and N-2'-hydroxy-(E)-Delta(3)-octadecenoate as the fatty acyl components. However, while the mycelial form expressed only beta-glucopyranosylceramide, the yeast form expressed both beta-gluco- and beta-galactopyranosylceramides in approximately equal amounts. In addition, while the glucosylceramides of both mycelial and yeast forms had similar proportions of saturated and (E)-Delta(3) unsaturated 2-hydroxy fatty acid, the galactocerebroside of the yeast form had significantly higher levels of (E)-Delta(3) unsaturation. The differences in cerebroside hexose structure represent a novel type of glycosphingolipid dimorphism not previously reported in fungi. Possible implications of these findings with respect to regulation of morphological transitions in S. schenckii and other dimorphic fungi are discussed. (+info)Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. (8/288)
The development of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. The inhibitors may serve as useful tools to clarify the role of endogenous oleamide and anandamide and may prove to be useful therapeutic agents for the treatment of sleep disorders or pain. The combination of several features-an optimal C12-C8 chain length, pi-unsaturation introduction at the corresponding arachidonoyl Delta(8,9)/Delta(11,12) and oleoyl Delta(9,10) location, and an alpha-keto N4 oxazolopyridine with incorporation of a second weakly basic nitrogen provided FAAH inhibitors with K(i)s that drop below 200 pM and are 10(2)-10(3) times more potent than the corresponding trifluoromethyl ketones. (+info)
Mixing brain cerebrosides with brain ceramides, cholesterol and phospholipids
The Effect of Cerebroside and Other Lipids on the Fixation of Tetanus Toxin by Gangliosides | Microbiology Society
Cerebroside sulfatase | enzyme | Britannica.com
Inhibition of in vitro peripheral myelin formation by monoclonal anti-galactocerebroside.<...
Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide | Science
lactosylceramidase
Summary Report | CureHunter
Sparrho | The inhibition of complement-dependent hemolysis by liposom
Root #2- sphingo- - Spellers Corner
Download Light 2004
The lipid composition of rat brain myelin and subcellular fractions during development | Biochemical Journal
Case Reports | Cryonics Institute
Lithography - AZoOptics Search
Lipid composition of the stratum corneum and cutaneous water loss in birds along an aridity gradient
A kinetic study of the effects of galactocerebroside 3-sulphate on human spleen glucocerebrosidase. Evidence for two activator...
Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy - Full Text View - ClinicalTrials.gov
Arylsulfatase A, 24 Hour, Urine -
Mayo Medical Laboratories | Genetics and Pharmacogenomics Catalog
NTSAD - Glossary - Glucocerebroside
Patterns of lipid changes with growth of chick sciatic nerve
Motional emf word problems worksheet
Acer3 upregulation is important for the homeostasis of | Open-i
OGT2378 | CAS#441061-33-2 | GCS inhibitor | MedKoo Biosciences
OTX2 Antibody (Monoclonal, 1H12C4B5)
Decrypt asterias | Words Decrypt d from letters asterias | Crypter Word asterias | Words Made with the Letters asterias
Efficacy METAZYM for the Treatment Metachromatic Leukodystrophy Treated With Hematopoietic Stem Cell Transplantation - Full...
DISEASES - Gauchers disease
Sphingolipid - Wikipedia
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Gauchers disease | Endocrine and metabolic diseases | ePharmaPedia
Concise Neurology by Alberto J. Espay MD MSc, José Biller MD FACP FAAN FAHA | Antonio Ceballos Books
Determination of arylsulfatase A pseudodeficiency allele and haplotype frequency in the Tunisian population - RIIP - Réseau...
Galactosylceramide | definition of galactosylceramide by Medical dictionary
Question What is Gauchers disease?
4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin | Lipids in Health and Disease | Full...
In vitro biosynthesis of sialosylgalactosylceramide (G<sub>7</sub>) by mouse brain...
PLTP - Phospholipid transfer protein precursor - Homo sapiens (Human) - PLTP gene & protein
11 letter words ending in de in the mammoth uncensored word list.
Plus it
Gauchers disease
Patent US4977286 - Glycolipids - Google Patents
LCBK1 - Sphingoid long-chain bases kinase 1 - Arabidopsis thaliana (Mouse-ear cress) - LCBK1 gene & protein
Gauchers disease Market Insights, Epidemiology and Market Forecast - 2023 United States | Medgadget
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PVC Membrane Sheet
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Globoid cell financial definition of globoid cell
Acute cerebral Gauchers disease synonyms, Acute cerebral Gauchers disease antonyms - FreeThesaurus.com
The sphingosine kinase inhibitor N, N-dimethylsphingosine inhibits neointimal hyperplasia - Strathprints
Beta Galactosidase | Infospaze - Sharing Wisdom by Community.
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IDEALS @ Illinois: Use of Fluorescence to Study the Membrane Binding Domain of Cytochrome B(5) and the Induction of Membrane...
DMOZ - Health: Conditions and Diseases: Nutritional and Metabolic Disorders: Cholesterol and Other Fats: Gauchers
Differential unmasking of adenylate cyclase activity (AC) in cardiac membrane sheets and vesicles<...
Astrophytum asterias Super Kabuto 1001
Astrophytum asterias Super Kabuto 1000
New Gaucher Drug Goes to Market During Shortage | Medpage Today
Curvilinear regression course of human brain lipid composition changes with age | SpringerLink
β-galactosidase/ZIF-8 MOF coating
How Oleamide works: 5 Easy to Understand Concepts
H. E. Carter
Configuration of cerebrosides. J. Biol. Chem. 221: 879-884. Carter, H. E., C. P. Schaffner, and D. Gottlieb. 1954. Levomycin. I ... Structure of the cerebrosides. J. Biol. Chem. 199: 283-288. Carter, H. E., D. Gottlieb, and H. W. Anderson. 1948. Chloromycetin ...
Sphingolipid
Cerebrosides have a single glucose or galactose at the 1-hydroxy position. Sulfatides are sulfated cerebrosides. Gangliosides ... yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids. ...
Metachromatic leukodystrophy
MLD involves cerebroside sulfate accumulation. Metachromatic leukodystrophy, like most enzyme deficiencies, has an autosomal ...
Soft laser desorption
1. Imaging of Cerebrosides Directly from Rat Brain Tissue". Analytical Chemistry. 79 (6): 2373-85. doi:10.1021/ac062251h. PMID ...
Glycolipid
Cerebrosides: a group glycosphingolipids involved in nerve cell membranes. Galactocerebrosides: a type of cerebroseide with ... "Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain". Journal of ... galactose as the saccharide moiety Glucocerebrosides: a type of cerebroside with glucose as the saccharide moiety; often found ...
GAL3ST1
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". ... Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. ... Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694 ...
Glycolipid transfer protein
Metz RJ, Radin NS (November 1982). "Purification and properties of a cerebroside transfer protein". The Journal of Biological ...
Sulfatide
Specifically, cerebroside sulfotransferase (CST) is elevated as it passes along a signaling pathway which involves: Hepatocyte ... This reaction is catalyzed by cerebroside sulfotransferase (CST). CST is a homodimeric protein that is found in the Golgi ... In peripheral nerves that are cerebroside sulfotransferase (CST) deficient, the nodes of Ranvier form enlarged axonal ... Consequently, the COS-7 cells were transfected with galactosyltransferase and cerebroside sulfotransferase genes from the Madin ...
Termitomycesphin
... s A-H are neuritogenic cerebrosides isolated from the mushroom Termitomyces albuminosus. Termitomycesphins G ... and H, additional cerebrosides from the edible Chinese mushroom Termitomyces albuminosus. ...
Lycium chinense
... two cerebrosides, and three pyrrole derivatives. Dozens of secondary metabolites have been isolated and identified from the ...
N-acylsphingosine galactosyltransferase
Fujino Y, Nakano M (1969). "Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose". Biochem. J. 113 ...
Bimal Kumar Bachhawat
His proposals on the biosynthesis and degradation of cerebroside-3-sulfate, a lipid found in high concentrations in patients ... Bimal K Bachhawat; James Austin; Donald Armstrong (1967). "A Cerebroside Sulphotransferase Deficiency in a Human Disorder of ... Farooqui, Bachhawat B. K. (1973). "Enzymic desulfation of cerebroside-3'-sulfate by chicken brain arylsulfatase". J. Neurochem ... B. K. (1965). "Formation of cerebroside sulfate from 3'-phosphoadenosine-5'phosphosulfate in sheep brain". Biochim. Biophys. ...
Lipid
Examples of these are the simple and complex glycosphingolipids such as cerebrosides and gangliosides. Sterols, such as ... cerebroside) and sphingolipids (sphingomyelin). The terms lipoid, lipin, lipide and lipid have been used with varied meanings ...
Cell membrane
Plasma membranes also contain carbohydrates, predominantly glycoproteins, but with some glycolipids (cerebrosides and ...
Lignoceric acid
It is found in wood tar, various cerebrosides, and in small amounts in most natural fats. The fatty acids of peanut oil contain ...
Convergent evolution
Birds and bats also share a high concentration of cerebrosides in the skin of their wings. This improves skin flexibility, a ...
Prosaposin
1991). "The organization of the gene for the human cerebroside sulfate activator protein". FEBS Lett. 280 (2): 267-70. doi: ... 1990). "The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein ...
Glucocerebroside
... (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose. ...
Globoside
A glycosphingolipid that has only one sugar as the side chain is called a cerebroside. The side chain can be cleaved by ...
2-Hydroxyacylsphingosine 1-beta-galactosyltransferase
Morell P, Radin NS (1969). "Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing ...
Membrane lipid
The simplest glycolipid is cerebroside, in which there is only one sugar residue, either Glc or Gal. More complex glycolipids, ...
GM2A
1990). "The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein ...
Myelinogenesis
At this time, [35S] Sulfate was incorporated into sulfatide and the activity of cerebroside, sulfotransferase reached a peak in ... In conclusion, the early phase of myelination was correlated with the increases synthesis of lipids, cholesterol, cerebroside, ... cerebroside, and sulfatide. As researchers began to do postnatal research, they found that myelinogenesis in the rat optic ...
Arylsulfatase A
... (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into ... cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. A deficiency is associated with metachromatic ...
Galactosylceramide sulfotransferase
Other names in common use include GSase, 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase, galactocerebroside ...
Galactosylceramide
A galactosylceramide, or galactocerebroside is a type of cerebroside consisting of a ceramide with a galactose residue at the 1 ...
Glycosphingolipid
... s include: Cerebrosides Gangliosides Globosides Gangliosides are mainly found in the cell membranes of the ... In the case of cerebrirosis, this affects the cerebrosides (examples are Gaucher's disease and Krabbe's disease), in case of ...
1-Deoxysphingolipids
... cerebrosides ...). Instead, they have toxic effects to the cell. Despite previous opinions that 1-deoxySLs are dead-end ...
UGT8
... cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26". Genomics. 34 (1): 69-75. doi ...
List of MeSH codes (D09)
... cerebrosides MeSH D09.400.410.420.525.200.250.450 - galactosylceramides MeSH D09.400.410.420.525.200.250.490 - ...
Cerebroside | Encyclopedia.com
cerebroside* Any one of a class of glycolipids [1] in which a single sugar unit is bound to a sphingolipid (see phospholipid [2 ... cerebroside Any one of a class of glycolipids in which a single sugar unit is bound to a sphingolipid (see phospholipid). The ... cerebrosides A Dictionary of Food and Nutrition © A Dictionary of Food and Nutrition 2005, originally published by Oxford ... cerebroside A Dictionary of Biology © A Dictionary of Biology 2004, originally published by Oxford University Press 2004. ...
cerebroside (CHEBI:23079)
... is a ceramide (CHEBI:17761) cerebroside (CHEBI:23079) is a neutral glycosphingolipid (CHEBI:25513) ... HexCer(d37:2) (CHEBI:138902) is a cerebroside (CHEBI:23079). hexosyl-(1↔1ʼ)-N-acylsphingosine (CHEBI:82917) is a cerebroside ( ... HexCer(d32:1) (CHEBI:138900) is a cerebroside (CHEBI:23079). HexCer(d33:2) (CHEBI:138901) is a cerebroside (CHEBI:23079). ... N-tetracosanoyl hexosylceramide (CHEBI:77463) is a cerebroside (CHEBI:23079). galactosylceramide (CHEBI:36498) is a cerebroside ...
Cerebroside sulfatase | enzyme | Britannica.com
Cerebroside - Wikipedia
"Fatty acid composition of cerebrosides and cerebroside sulphatides in cerebral oedema". Acta Neuropathologica. 12 (1): 62-67. ... Cerebroside molecules are able form up to eight intermolecular hydrogen bonds between the polar hydrogens of the sugar and the ... Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves. These ... Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. The sugar moiety is linked ...
Cerebroside-sulfatase - Wikipedia
Cerebroside-sulfatase (EC 3.1.6.8, arylsulfatase A, cerebroside sulfate sulfatase) is an enzyme with systematic name ... Cerebroside-sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... This enzyme catalyses the following chemical reaction a cerebroside 3-sulfate + H2O ⇌ {\displaystyle \rightleftharpoons } a ... cerebroside + sulfate This enzyme hydrolyses galactose-3-sulfate residues in a number of lipids. Arylsulfatase A Mehl E, ...
Cerebroside - definition of cerebroside by The Free Dictionary
cerebroside synonyms, cerebroside pronunciation, cerebroside translation, English dictionary definition of cerebroside. n. Any ... cerebroside. Also found in: Medical, Encyclopedia, Wikipedia.. Related to cerebroside: ganglioside. cer·e·bro·side. (sĕr′ə-brə- ... IFB-121 * Cerebroside 1 * Cerebroside 2 Phornopsis sp.. Endophytic fungi--the treasure chest of antibacterial substances ... Cerebroside - definition of cerebroside by The Free Dictionary https://www.thefreedictionary.com/cerebroside ...
Cerebroside-sulfatase | definition of cerebroside-sulfatase by Medical dictionary
What is cerebroside-sulfatase? Meaning of cerebroside-sulfatase medical term. What does cerebroside-sulfatase mean? ... Looking for online definition of cerebroside-sulfatase in the Medical Dictionary? cerebroside-sulfatase explanation free. ... cerebroside-sulfatase. cer·e·bro·side-sul·fa·tase. , cerebroside sulfatidase. an enzyme that cleaves sulfate from a sulfated ... A gene on chromosome 22q13.31-qter that encodes arylsulfatase A, which hydrolyses cerebroside sulfate to cerebroside and ...
800-342-3595 | Cerebrosides | Lipids and Biochemicals - Matreya, LLC.
... ceramide beta-D-galactoside This cerebroside product is a glycosphingolipid containing a galactose (galactocerebroside) ... Scientific Name:Cerebrosides, bovine. *Common Name:Galactosylceramide; Ceramide beta-D-galactoside (contains both hydroxy and ... This cerebroside product is a glycosphingolipid containing a galactose (galactocerebroside) attached to a ceramide acylated ... This leads to an accumulation of cerebroside and psychosine (which is very cytotoxic and can result in demyelination of nerves ...
The American Journal of Tropical Medicine and Hygiene | Elevated Cerebroside Antibody Levels in Human Visceral and Cutaneous...
Cerebroside antibody binding activity was only partially blocked by 0.5 M galactose or α- and β-methylgalactopyranoside, ... Abstract A natural cerebroside (antiC) IgM antibody was found at relatively high levels in the serum of every healthy ... A natural cerebroside (antiC) IgM antibody was found at relatively high levels in the serum of every healthy individual studied ... Cerebroside antibody binding activity was only partially blocked by 0.5 M galactose or α- and β-methylgalactopyranoside, ...
Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats | Lipids in Health and...
The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from ... And the cerebroside was also reported to regulate lipid levels according to Cohn Jeffrey [24]. The marine cerebroside displayed ... Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. *Bei Zhang1. , ... Gao Z, Zhou X, Hu XQ, Xue CH, Xu J, Wang YM: Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose ...
Mixing brain cerebrosides with brain ceramides, cholesterol and phospholipids
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Cerebroside | definition of cerebroside by Medical dictionary
... cerebroside explanation free. What is cerebroside? Meaning of cerebroside medical term. What does cerebroside mean? ... Looking for online definition of cerebroside in the Medical Dictionary? ... cerebroside. Also found in: Dictionary, Encyclopedia, Wikipedia.. Related to cerebroside: ganglioside. cerebroside. [sĕ-re´bro- ... The sulfate esters of cerebrosides are among the sulfatidates.. cerebroside. /cer·e·bro·side/ (ser´ĕ-bro-sīd″) a general ...
FIGURE 10.33 Map of North America showing the continental | bartleby
Stereospecific binding of narcotics to cerebroside sulfates<...
Cho, T. M. ; Wu, Y. C. ; Loh, H. H. ; Way, E. L. / Stereospecific binding of narcotics to cerebroside sulfates. In: ... Cho, T. M., Wu, Y. C., Loh, H. H., & Way, E. L. (1974). Stereospecific binding of narcotics to cerebroside sulfates. ... Cho, TM, Wu, YC, Loh, HH & Way, EL 1974, Stereospecific binding of narcotics to cerebroside sulfates, Pharmacologist, vol. 16 ... Stereospecific binding of narcotics to cerebroside sulfates. / Cho, T. M.; Wu, Y. C.; Loh, H. H.; Way, E. L. ...
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Cerebrosides isolated from Arisaema flavum | China Journal of Chinese Materia Medica;(24): 2466-2472, 2016. | WPRIM
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Two types of detergent-insoluble, glycosphingolipid/cholesterol-rich membrane domains from isolated myelin - Arvanitis - 2005 -...
A model system for opiate-receptor interactions: Mechanism of opiate-cerebroside sulfate interaction - Fingerprint
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Gaucher disease: MedlinePlus Genetics
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Wiley: Lipidomics: Comprehensive Mass Spectrometry of Lipids - Xianlin Han
LipidsGangliosidesSulfateCeramideCeramidesGlycosphingolipidsSphingosineGlycolipidsSulfataseMelting point of cerebrosidesAntimicrobial CerebrosideSulfotransferaseMyelinSynthesisDeficiencyCholesterolGaucherGlucosylceramideGangliosideFattyEuphorbiaGalactoseGlycosidesCarbohydrateAntibacterialAccumulationMiceMoleculesRelatively highBrainBiologicalActivityStructure
Lipids3
- cerebrosides Complex lipids, containing the carbohydrate galactose , important in the myelin sheath of nerves. (encyclopedia.com)
- This enzyme catalyses the following chemical reaction a cerebroside 3-sulfate + H2O ⇌ {\displaystyle \rightleftharpoons } a cerebroside + sulfate This enzyme hydrolyses galactose-3-sulfate residues in a number of lipids. (wikipedia.org)
- any of a class of lipids , comprising the cerebrosides and gangliosides, that upon hydrolysis yield galactose or a similar sugar, a fatty acid, and sphingosine or dihydrosphingosine. (dictionary.com)
Gangliosides3
- On cerebrosides and gangliosides. (bris.ac.uk)
- Glycosphingolipids may be further subdivided into cerebrosides and gangliosides. (humpath.com)
- Cerebrosides have a single glucose or galactose at the 1-hydroxy position, while gangliosides have at least three sugars, one of which must be sialic acid. (humpath.com)
Sulfate5
- Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves. (wikipedia.org)
- Cerebroside-sulfatase (EC 3.1.6.8, arylsulfatase A, cerebroside sulfate sulfatase) is an enzyme with systematic name cerebroside-3-sulfate 3-sulfohydrolase. (wikipedia.org)
- A gene on chromosome 22q13.31-qter that encodes arylsulfatase A, which hydrolyses cerebroside sulfate to cerebroside and sulfate. (thefreedictionary.com)
- The sulfate esters of cerebrosides are among the sulfatidates. (thefreedictionary.com)
- Existence of Cerebroside and Cholesterol Sulfate in the Tissues of the Sea Star Asterias rubens . (springer.com)
Ceramide6
- The fundamental structure of a cerebroside is ceramide. (wikipedia.org)
- Monoglycosyl and oligoglycosylceramides having a mono or polysaccharide bonded glycosidically to the terminal OH group of ceramide are defined as cerebrosides. (wikipedia.org)
- Cerebroside molecules are able form up to eight intermolecular hydrogen bonds between the polar hydrogens of the sugar and the hydroxy and amide groups of the sphingosine base of the ceramide. (wikipedia.org)
- Phytochemical studies of EB have revealed the presence of various compounds like coumarin, [beta]-sitosterol, cerebroside , ceramide and quercetin 3-o-rutinoside. (thefreedictionary.com)
- This cerebroside product is a glycosphingolipid containing a galactose (galactocerebroside) attached to a ceramide acylated with hydroxy and non-hydroxy fatty acids. (matreya.com)
- The properties of bilayers composed of pure brain cerebroside (bCrb) or of binary mixtures of bCrb with brain ceramide, cholesterol, egg phosphatidylcholine or brain sphingomyelin have been studied using a combination of physical techniques. (ehu.es)
Ceramides1
- Examples are sphingomyelins, ceramides, and cerebrosides. (thefreedictionary.com)
Glycosphingolipids1
- Cerebrosides is the common name for a group of glycosphingolipids called monoglycosylceramides which are important components in animal muscle and nerve cell membranes. (wikipedia.org)
Sphingosine1
- Cerebrosides are an example which contain the sphingosine backbone attached to a fatty acid and a carbohydrate. (libretexts.org)
Glycolipids3
- cerebroside Any one of a class of glycolipids in which a single sugar unit is bound to a sphingolipid (see phospholipid ). (encyclopedia.com)
- The melting point of cerebrosides is considerably greater than physiological body temperature, >37.0 °C, giving glycolipids a paracrystalline, similar to liquid crystal structure. (wikipedia.org)
- Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by C18-4, 8-sphingadienine, α-hydroxy acid and a saccharide head. (sioc.ac.cn)
Sulfatase2
- called arylsulfatase A (ASA), or cerebroside sulfatase . (britannica.com)
- Very low arylsulfatase A and cerebroside sulfatase activities in leukocytes of healthy members of metachromatic leukodystrophy family. (thefreedictionary.com)
Melting point of cerebrosides1
- Due to the relatively high melting point of cerebrosides (much greater than physiological body temperature) they have a para-crystalline structure. (matreya.com)
Antimicrobial Cerebroside1
- Pinelloside, an antimicrobial cerebroside from Pinellia ternata. (webmd.com)
Sulfotransferase1
- cerebroside sulfotransferase knockout mice. (thefreedictionary.com)
Myelin3
- Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. (wikipedia.org)
- Cerebrosides are found in the myelin sheath of nerve tissue, for example, kerasin, nervon, oxynervon, phrenosin, these names are also used for the fatty acid involved. (thefreedictionary.com)
- cerebrosides are found in the myelin sheath of nerve tissue. (thefreedictionary.com)
Synthesis2
- Synthesis of a New Cerebroside from a Chondropsis sp. (nii.ac.jp)
- S. Ogawa and H. Tsunoda , Chemical Synthesis of Glycosylamide and Cerebroside Analogs Composed of Carba Sugars. (elsevier.com)
Deficiency1
- The deficiency of arylsulphatase A leads to storage of cerebroside sulphate in the neural tissues. (thefreedictionary.com)
Cholesterol2
- In addition, there is reduction in accumulation of cholesterol, phospholipid, and cerebroside , which affects the cerebellar function. (thefreedictionary.com)
- Isolation of Large Amounts of Cerebroside and Cholesterol Sulphate in the Sea Star Asterias rubens . (springer.com)
Gaucher1
- Increased cerebroside concentration in plasma and erythrocytes in Gaucher disease: significant differences between type I and type III. (thefreedictionary.com)
Glucosylceramide1
- Cerebroside is sometimes prefixed by gluco-, galacto-, among others, in place of the correct glucosylceramide, and the like. (thefreedictionary.com)
Ganglioside3
- SUMMARY: Water-insoluble complexes of ganglioside with cerebroside fixed tetanus toxin at low concentrations (a few LD 50/ml.) of toxin. (microbiologyresearch.org)
- A complex containing 25% ganglioside with cerebroside was 50 times better at fixing toxin than complexes containing either 2% or 50% ganglioside. (microbiologyresearch.org)
- The complex of cerebroside and ganglioside, containing 25% ganglioside, did not fix strychnine, serotonin, botulinum toxin or plasma albumin. (microbiologyresearch.org)
Fatty1
- The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from Acaudina molpadioides in fatty liver rats. (biomedcentral.com)
Euphorbia3
- Banfi, New Cerebroside from Euphorbia peplis, Antimicrobial Activity Evaluation. (thefreedictionary.com)
- The known cerebrosides isolated from Euphorbia peplis L. (thefreedictionary.com)
- New cerebrosides from Euphorbia peplis L.: Antimicrobial activity evaluation. (thefreedictionary.com)
Galactose2
- Cerebroside antibody binding activity was only partially blocked by 0.5 M galactose or α- and β-methylgalactopyranoside, suggesting poor specificity of antiC for a specific glycosidic residue or linkage. (ajtmh.org)
- Cerebrosides have a single glucose or galactose at the 1-hydroxy position. (bionity.com)
Glycosides1
- Examples are sterol glycosides, cerebrosides, and plant phytoglycolipids. (thefreedictionary.com)
Carbohydrate1
- A lipid, such as a cerebroside, that contains carbohydrate groups. (dictionary.com)
Antibacterial2
- Spathoside, a cerebroside and other antibacterial constituents of the stem bark of Spathodea campanulata. (thefreedictionary.com)
- Antibacterial and xanthine oxidase inhibitory cerebrosides from Fusarium sp IFB-121, an endophytic fungus in Quercus variabilis. (thefreedictionary.com)
Accumulation1
- This leads to an accumulation of cerebroside and psychosine (which is very cytotoxic and can result in demyelination of nerves and loss of axonal conductivity). (matreya.com)
Mice1
- Rebuilding the balance of STAT-1 and STAT3 signalings by fusaruside, a cerebroside compound, for the treatment of T-cell-mediated fulminant hepatitis in mice. (thefreedictionary.com)
Molecules1
- These hydrogen bonds within the cerebrosides result in the molecules having a high transition temperature and compact alignment. (wikipedia.org)
Relatively high1
- A natural cerebroside (antiC) IgM antibody was found at relatively high levels in the serum of every healthy individual studied. (ajtmh.org)
Brain1
- Eicosenoic acid is important in the production of cerebrosides , which are components of nerve membranes and the "white substance" of the brain. (thefreedictionary.com)
Biological1
- 7. Barreto-Bergter, E., Pinto, M.R. & Rodrigues, M.L. 2004 Structure and biological functions of fungal cerebrosides. (fgsc.net)
Activity1
- New cerebroside and chondrocyte proliferation activity of Caryota mitis L. (nih.gov)
Structure1
- Structure of Cerebrosides. (degruyter.com)