Cerebrosides: Neutral glycosphingolipids that contain a monosaccharide, normally glucose or galactose, in 1-ortho-beta-glycosidic linkage with the primary alcohol of an N-acyl sphingoid (ceramide). In plants the monosaccharide is normally glucose and the sphingoid usually phytosphingosine. In animals, the monosaccharide is usually galactose, though this may vary with the tissue and the sphingoid is usually sphingosine or dihydrosphingosine. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1st ed)Sulfoglycosphingolipids: GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.Glucosylceramides: Cerebrosides which contain as their polar head group a glucose moiety bound in glycosidic linkage to the hydroxyl group of ceramides. Their accumulation in tissue, due to a defect in beta-glucosidase, is the cause of Gaucher's disease.Cerebroside-Sulfatase: An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside and inorganic sulfate. A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.8.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Leukodystrophy, Metachromatic: An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.Sea Cucumbers: A class of Echinodermata characterized by long, slender bodies.Termitomyces: A paleotropical genus of fungi in the family Tricholomataceae. They are obligate symbionts of termites.Galactosylceramides: Cerebrosides which contain as their polar head group a galactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in beta-galactosidase, is the cause of galactosylceramide lipidosis or globoid cell leukodystrophy.N-Acylsphingosine Galactosyltransferase: An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylceramide and UDP.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)Schizophyllum: A genus of fleshy shelf basidiomycetous fungi, family Schizophyllaceae, order POLYPORALES, growing on woody substrata. It is pathogenic in humans.Sphingolipid Activator Proteins: A family of glycoprotein cofactors that are required for the efficient catabolization of SPHINGOLIPIDS by specific acid hydrolases such as GLUCOSYLCERAMIDASE; GALACTOCEREBROSIDASE; BETA-N-ACETYLHEXOSAMINIDASE; and CEREBROSIDE-SULFATASE.Sphingolipids: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Harderian Gland: A sebaceous gland that, in some animals, acts as an accessory to the lacrimal gland. The harderian gland excretes fluid that facilitates movement of the third eyelid.Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.Glycosphingolipids: Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)HexosesMyelin Sheath: The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.Saposins: A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred to as prosaposin.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Asterias: A genus of STARFISH in the family Asteriidae. One species, Asterias rubens, is the most common in the north-east Atlantic region.SulfatasesPsychosine: An intermediate in the biosynthesis of cerebrosides. It is formed by reaction of sphingosine with UDP-galactose and then itself reacts with fatty acid-Coenzyme A to form the cerebroside.Amino Alcohols: Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).Gangliosides: A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997)Hydroxy Acids: Organic compounds containing both the hydroxyl and carboxyl radicals.Water Loss, Insensible: Loss of water by diffusion through the skin and by evaporation from the respiratory tract.Lactosylceramides: Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Sulfotransferases: Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.Sulfuric Acids: Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.Sterculia: A plant genus of the family STERCULIACEAE. S. urens is the source of KARAYA GUM which is sometimes called Indian tragacanth, which is different from the true TRAGACANTH which comes from ASTRAGALUS GUMMIFER.Globosides: Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.Steryl-Sulfatase: An arylsulfatase with high specificity towards sulfated steroids. Defects in this enzyme are the cause of ICHTHYOSIS, X-LINKED.Nerve Tissue: Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.Arylsulfatases: Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Taxes: Governmental levies on property, inheritance, gifts, etc.Prescription Fees: The charge levied on the consumer for drugs or therapy prescribed under written order of a physician or other health professional.Philately: Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.Great BritainGermanyMedicine, Arabic: Traditional Arabic methods used in medicine in the ARAB WORLD.Meat Products: Articles of food which are derived by a process of manufacture from any portion of carcasses of any animal used for food (e.g., head cheese, sausage, scrapple).Meat: The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.Exhibits as Topic: Discussions, descriptions or catalogs of public displays or items representative of a given subject.Nutritional Sciences: The study of NUTRITION PROCESSES as well as the components of food, their actions, interaction, and balance in relation to health and disease.United States Department of Agriculture: A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.Nutritional Physiological Phenomena: The processes and properties of living organisms by which they take in and balance the use of nutritive materials for energy, heat production, or building material for the growth, maintenance, or repair of tissues and the nutritive properties of FOOD.Plants, Edible: An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.

Partial purification and properties of porcine thymus lactosylceramide beta-galactosidase. (1/288)

Porcine thymus lactosylceramide beta-galactosidase was purified by a simple procedure. In the final step of isoelectric focusing the enzyme was separated into two peaks of pI 6.3 (peak I) and 7.0 (peak II), which showed 3,600- and 4,000-fold enhancement of lactosylceramide-hydrolysing activity, respectively. The two peaks had identical mobility on polyacrylamide gel electrophoresis. The apparent molecular weight was 34,000. Neither monosialoganglioside (GM1) nor galactosylceramide was hydrolysed by the purified enzyme fractions. The optimal pH was at 4.6, and sodium taurocholate was essential for the reaction. The apparent Km was 2.3 x 10-5 M. The reaction was stimulated by sodium chloride and linoleic acid, while it was strongly inhibited by Triton X-100 and bovine serum albumin. Galactosylceramide, p-nitrophenyl beta-galactoside, and p-nitrophenol were weak inhibitors. No effects of GM1 and galactose were observed on the hydrolysis of lactosylceramide.  (+info)

Synthesis and turnover of cerebrosides and phosphatidylserine of myelin and microsomal fractions of adult and developing rat brain. (2/288)

The synthesis and turnover of cerebrosides and phospholipids was followed in microsomal and myelin fractions of developing and adult rat brains after an intracerebral injection of [U-14C]serine. The kinetics of incorporation of radioactivity into microsomal and myelin cerebrosides indicate the possibility of a precursor-product relationship between cerebrosides of these membranes. The specific radioactivity of myelin cerebrosides was corrected for the deposition of newly formed cerebrosides in myelin. Multiphasic curves were obtained for the decline in specific radioactivity of myelin and microsomal cerebrosides, suggesting different cerebroside pools in these membranes. The half-life of the fast turning-over pool of cerebrosides of myelin was 7 and 22 days for the developing and adult rat brain respectively. The half-life of the slowly turning-over pool of myelin cerebrosides was about 145 days for both groups of animals. The half-life of the rapidly turning-over microsomal cerebrosides was calculated to be 20 and 40 h for the developing and adult animals respectively. The half-life of the intermediate and slowly turning-over microsomal cerebrosides was 11 and 60 days respectively, for both groups of animals. The amount of incorporation of radioactivity into microsomal cerebrosides from L-serine was greatly decreased in the adult animals, and greater amounts of the precursor were directed towards the synthesis of phosphatidylserine. In the developing animals, considerable amounts of cerebrosides were synthesized from L-serine, besides phosphatidylserine. The time-course of incorporation indicated that a precursor-product relationship exists between microsomal and myelin phosphatidylserine. The half-life of microsomal phosphatidylserine was calculated to be about 8 h for the fast turning-over pool in both groups of animals.  (+info)

Divalent cation-mediated interaction between cerebroside sulfate and cerebrosides: an investigation of the effect of structural variations of lipids by electrospray ionization mass spectrometry. (3/288)

Divalent cations mediate a carbohydrate-carbohydrate association between the two major glycolipids, galactosylceramide (GalCer) and its sulfated form, cerebroside sulfate (CBS), of the myelin sheath. We have suggested that interaction between these glycolipids on apposed extracellular surfaces of myelin may be involved in the stability or function of this multilayered structure. A mutant mouse lacking galactolipids because of a disruption in the gene that encodes a galactosyltransferase forms myelin that initially appears relatively normal but is unstable. This myelin contains glucosylceramide (GlcCer) instead of GalCer. To better understand the role of GlcCer in myelin in this mutant, we have compared the ability of divalent cations to complex CBS (galactosyl form) with GlcCer or GalCer in methanol solution by using positive ion electrospray ionization mass spectrometry. Because both the alpha-hydroxylated fatty acid species (HFA) and the nonhydroxylated fatty acid species (NFA) of these lipids occur in myelin, we have also compared the HFA and NFA species. In addition to monomeric Ca2+ complexes of all three lipids and oligomeric Ca2+ complexes of both GalCer and GlcCer, Ca2+ also caused heterotypic complexation of CBS to both GalCer and GlcCer. The heterotypic complexes had the greatest stability of all oligomers formed and survived better at high declustering potentials. Complexes of CBS with GlcCer were less stable than those with GalCer. This was confirmed by using the free sugars and glycosides making up the carbohydrate headgroups of these lipids. HFA species of CBS and GalCer formed more stable complexes than NFA species, but hydroxylation of the fatty acid of GlcCer had no effect. The ability of GlcCer to also complex with CBS, albeit with lower stability, may allow GlcCer to partially compensate for the absence of GalCer in the mouse mutant.  (+info)

Forssman penta- and tetraglycosylceramide are xenoantigens of ostrich kidney and liver. (4/288)

The heterophile antigens Galalpha1-->3Gal and N-glycolylneuraminic acid are the major obstacle to grafting mammal organs, especially from pig, to man. Lack of expression of these common xenoantigens by birds has raised interest in ostrich as a potential organ donor for xenotransplantation. Glycosphingolipids of ostrich liver and kidney were investigated for their carbohydrate determinants. Both organs were found similar in their glycolipid composition with three major species, mono-, di-, and pentaglycosylceramide. The pentaglycosylceramide was characterized as the Forssman antigen. In both organs, the ceramide portion was highly hydroxylated with prevalence of alpha-hydroxylated fatty acids, C18 phytosphingosine in kidney and C18 sphingosine in liver Forssman glycolipid. These data indicate that hydroxylation of kidney glycosphingolipids, which is found in mammals, has been maintained since the divergence of birds from other vertebrates. Characterization of a minor glycolipid as a Forssman tetraglycosylceramide built on the galabiosylceramide core indicates that the Forssman tetraglycosylceramide also exists in vivo. Its precursors, galactosyl- and galabiosylceramide, were characterized in kidney and liver. The Forssman antigen is the third heterophile antigen against which man raises natural antibodies. Its localization in the vascular endothelium and connective tissue makes ostrich an unpromising organ or cell donor for xenotransplantation to man.  (+info)

Lipid-dependent targeting of G proteins into rafts. (5/288)

Domains rich in sphingolipids and cholesterol, or rafts, may organize signal transduction complexes at the plasma membrane. Raft lipids are believed to exist in a state similar to the liquid-ordered phase. It has been proposed that proteins with a high affinity for an ordered lipid environment will preferentially partition into rafts (Melkonian, K. A., Ostermeyer, A. G., Chen, J. Z., Roth, M. G., and Brown, D. A. (1999) J. Biol. Chem. 274, 3910-3917). We investigated the possibility that lipid-lipid interactions between lipid-modified proteins and raft lipids mediate targeting of proteins to these domains. G protein monomers or trimers were reconstituted in liposomes, engineered to mimic raft domains. Assay for partitioning of G proteins into rafts was based on Triton X-100 insolubility. Myristoylation and palmitoylation of Galpha(i) were necessary and sufficient for association with liposomes and partitioning into rafts. Strikingly, the amount of fatty-acylated Galpha(i) in rafts was significantly reduced when myristoylated Galpha(i) was thioacylated with cis-unsaturated fatty acids instead of saturated fatty acids such as palmitate. Prenylated betagamma subunits were excluded from rafts, whether reconstituted alone or with fatty-acylated alpha subunits. These results suggest that the structural difference between lipids that modify proteins is one basis for the selectivity of protein targeting to rafts.  (+info)

Trans interactions between galactosylceramide and cerebroside sulfate across apposed bilayers. (6/288)

The two glycosphingolipids galactosylceramide (GalC) and its sulfated form, cerebroside sulfate (CBS), are present at high concentrations in the multilayered myelin sheath and are involved in carbohydrate-carbohydrate interactions between the lipid headgroups. In order to study the structure of the complex of these two glycolipids by Fourier transform infrared (FTIR) spectroscopy, GalC dispersions were combined with CBS dispersions in the presence and absence of Ca(2+). The FTIR spectra indicated that a strong interaction occurred between these glycolipids even in the absence of Ca(2+). The interaction resulted in dehydration of the sulfate, changes in the intermolecular hydrogen bonding interactions of the sugar and other oxygens, decreased intermolecular hydrogen bonding of the amide C==O of GalC and dehydration of the amide region of one or both of the lipids in the mixture, and disordering of the hydrocarbon chains of both lipids. The spectra also show that Ca(2+) interacts with the sulfate of CBS. Although they do not reveal which other groups of CBS and GalC interact with Ca(2+) or which groups participate in the interaction between the two lipids, they do show that the sulfate is not directly involved in interaction with GalC, since it can still bind to Ca(2+) in the mixture. The interaction between these two lipids could be either a lateral cis interaction in the same bilayer or a trans interaction between apposed bilayers. The type of interaction between the lipids, cis or trans, was investigated using fluorescent and spin-label probes and anti-glycolipid antibodies. The results confirmed a strong interaction between the GalC and the CBS microstructures. They suggested further that this interaction caused the CBS microstructures to be disrupted so that CBS formed a single bilayer around the GalC multilayered microstructures, thus sequestering GalC from the external aqueous phase. Thus the CBS and GalC interacted via a trans interaction across apposed bilayers, which resulted in dehydration of the headgroup and interface region of both lipid bilayers. The strong interaction between these lipids may be involved in stabilization of the myelin sheath.  (+info)

Dimorphic expression of cerebrosides in the mycopathogen Sporothrix schenckii. (7/288)

Major neutral glycosphingolipid components were extracted from Sporothrix schenckii, a dimorphic fungus exhibiting a hyphal saprophytic phase and a yeast parasitic phase responsible for chronic mycotic infections in mammalian hosts. These components, one from the mycelial form and two from the yeast form, were purified and their structures were elucidated by (1)H nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and tandem ESI-MS/MS. All three were characterized as cerebrosides (monohexosylceramides) containing (4E, 8E)-9-methyl-4,8-sphingadienine as the long-chain base attached to N-2'-hydroxyoctadecanoate and N-2'-hydroxy-(E)-Delta(3)-octadecenoate as the fatty acyl components. However, while the mycelial form expressed only beta-glucopyranosylceramide, the yeast form expressed both beta-gluco- and beta-galactopyranosylceramides in approximately equal amounts. In addition, while the glucosylceramides of both mycelial and yeast forms had similar proportions of saturated and (E)-Delta(3) unsaturated 2-hydroxy fatty acid, the galactocerebroside of the yeast form had significantly higher levels of (E)-Delta(3) unsaturation. The differences in cerebroside hexose structure represent a novel type of glycosphingolipid dimorphism not previously reported in fungi. Possible implications of these findings with respect to regulation of morphological transitions in S. schenckii and other dimorphic fungi are discussed.  (+info)

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. (8/288)

The development of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. The inhibitors may serve as useful tools to clarify the role of endogenous oleamide and anandamide and may prove to be useful therapeutic agents for the treatment of sleep disorders or pain. The combination of several features-an optimal C12-C8 chain length, pi-unsaturation introduction at the corresponding arachidonoyl Delta(8,9)/Delta(11,12) and oleoyl Delta(9,10) location, and an alpha-keto N4 oxazolopyridine with incorporation of a second weakly basic nitrogen provided FAAH inhibitors with K(i)s that drop below 200 pM and are 10(2)-10(3) times more potent than the corresponding trifluoromethyl ketones.  (+info)

SUMMARY: Water-insoluble complexes of ganglioside with cerebroside fixed tetanus toxin at low concentrations (a few LD 50/ml.) of toxin. A complex containing 25% ganglioside with cerebroside was 50 times better at fixing toxin than complexes containing either 2% or 50% ganglioside. A complex containing 25% of a mixture of the gangliosides Giii and Giv was 12 times better at fixing toxin than a similar complex with gangliosides Gi and GII. Complexes of ganglioside with sphingomyelin and lecithin fixed toxin to a slight extent, while complexes with tripalmitin and cholesterol did not fix toxin. The complex of cerebroside and ganglioside, containing 25% ganglioside, did not fix strychnine, serotonin, botulinum toxin or plasma albumin.
Cerebroside sulfatase: …called arylsulfatase A (ASA), or cerebroside sulfatase. Arylsulfatase A deficiency allows certain harmful sulfur-containing lipids, known as sulfosphingolipids (also called sulfatides), to accumulate in nerve tissues of the central nervous system instead of being broken down. Sulfatides can also accumulate in nerve tissue in organs, such as the kidneys and…
Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neural cells. ...
lactosylceramidase: ceramide-Glc-Gal & H2O gives Cer-Glc & galactose; deficiency gives lactosylceramidosis; see also lactosylceramidase II which acts GM(1) ganglioside
The root sphingo- comes from the Greek word sphingein which means to to hold fast. There are 12 different entries containing this root. glycosphingolipid- any of various lipids (such as a cerebroside or a ganglioside) sphingometer- an instrument for measuring the bending of a strut (as by deflection of beams of light) sphingomyelin- any of…
1. The lipids of whole brain and subcellular fractions of the rat were analysed during development. 2. The deposition of cholesterol occurred in two phases, one related to increasing wet weight of the brain and the second to myelination. Cerebroside accumulation was related only to myelination. 3. The composition of myelin isolated from 12-day-old rat brain was different in some respects from that of the adult. In the former there was an increase of phospholipid in relation to cholesterol and a marked deficiency in cerebroside. 4. It is suggested that early myelin is extruded glial plasma membrane, which only later becomes mature myelin.. ...
At the foundation of embalming is formalin, an aqueous solution saturated with formaldehyde gas, which constitutes 40% by volume and 37% by weight of the solution. Formaldehyde coagulates protoplasmic protein, turning it from a soft soluble form to a hard insoluble form which is resistant to both autolytic and bacterial proteolytic enzymes. Moreover, formaldehyde kills bacteria by coagulating bacterial protoplasm and has a drying effect upon tissue because of its strong affinity for water. Because formaldehyde preserves lipids as well as proteins, it would seem to be especially of value for the brain. A study of human brains preserved in formaldehyde for up to 24 years showed that the preservation of lipids was not uniform: cholesterol, cerebrosides, sulphatides, phosphoinositides and sphingomyelin remained unaffected, whereas lecithin, phosphatidylethanolamine and phosphadidylserine were broken down [THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY; 10:704-709 (1962)]. Because unbuffered ...
NPGS is the top selling SEM lithography system at research institutions in North America, and its use is becoming widespread around the world. The objective for NPGS is to provide a powerful ...
article{8f49d55d-b5f5-4f7b-bd69-f3ec250ab558, abstract = {Intercellular and covalently bound lipids within the stratum corneum (SC), the outermost layer of the epidermis, are the primary barrier to cutaneous water loss (CWL) in birds. We compared CWL and intercellular SC lipid composition in 20 species of birds from desert and mesic environments. Furthermore, we compared covalently bound lipids with CWL and intercellular lipids in the lark family (Alaudidae). We found that CWL increases in birds from more mesic environments, and this increase was related to changes in intercellular SC lipid composition. The most consistent pattern that emerged was a decrease in the relative amount of cerebrosides as CWL increased, a pattern that is counterintuitive based on studies of mammals with Gaucher disease. Although covalently bound lipids in larks did not correlate with CWL, we found that covalently bound cerebrosides correlated positively with intercellular cerebrosides and intercellular cholesterol ...
Extraction of control human spleen glucocerebrosidase with sodium cholate and butan-l-ol reversibly inactivates the enzyme in terms of its ability to hydrolyse the water-soluble substrate 4-methylumbelliferyl beta-D-glucopyranoside (MUGlc). The acidic brain lipid galactocerebroside 3-sulphate (sulphatide) reconstitutes beta-glucosidase activity in a strongly concentration-dependent manner. In this study we show that sulphatide exhibits three critical micellar concentrations (CMCs): CMC1, 3.72 microM; CMC2, 22.6 microM; CMC3, 60.7 microM. We designate the aggregates formed at these CMCs as primary, secondary and tertiary micelles respectively. From the results of kinetic studies performed at various sulphatide concentrations (0.012-248 microM), we found that sulphatide monomers (less than 3 microM) decreased the Km (for MUGlc) of control glucocerebrosidase from 11 to 4.6 mM, and lowered the Vmax. 2-fold. However, secondary and tertiary micelles were required for expression of high control ...
Metachromatic Leukodystrophy (MLD) is a rare autosomal recessive disorder caused by the deficiency of the Arylsulfatase A enzyme (ARSA), resulting in accumulation of galactosyl sulfatide (cerebroside sulfate), a major constituent of the myelin sheath. Accumulation of sulfatides leads to a progressive degeneration of the white matter in the central and peripheral nervous systems (CNS, PNS) and to a neuronal degeneration. The late-infantile form of MLD, which is usually diagnosed in the second year of life, is the most frequent and severe form of the disease. The prognosis is severe, leading to vegetative stage or death within few years after the diagnosis. There is no treatment for patients affected with this early-onset form of the disease.. Conventional MRI (1.5 Tesla) shows extensive involvement of the cerebral white matter (hypo-T1, hyper- T2 and FLAIR signals) indicative of rapidly progressing leukodystrophy. Early cortical atrophy reflects associated neuronal involvement. Proton MR ...
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by a deficiency of the arylsulfatase A (ARSA) enzyme, which leads to the accumulation of galactosyl sulfatide (cerebroside sulfate) in the white matter of the central nervous system and in the peripheral nervous system. Galactosyl sulfatide and, to a smaller extent, lactosyl sulfatide, also accumulate within the kidney, gallbladder, and other visceral organs and are excreted in excessive amounts in the urine.. The 3 clinical forms of MLD are late-infantile, juvenile, and adult, depending on age of onset. All result in progressive neurologic changes and leukodystrophy demonstrated on magnetic resonance imaging. Late-infantile MLD is the most common (50%-60% of cases) and usually presents between age 1 to 2 years with hypotonia, clumsiness, diminished reflexes, and slurred speech. Progressive neurodegeneration occurs and most patients die within 5 years of the diagnosis. Juvenile MLD (20%-30% of cases) is characterized by ...
Phospholipids and cerebrosides of the normal chick sciatic nerve were extracted by Folch procedures and separated with silica gel thin-layer chromatography using various chloroform-methanol solvents. The subsequent chemical assays were expressed as a function of the developmental stages of the chick from 15 days of incubation to 7 days after hatching (28 days from onset of incubation). A histological study of chick sciatic nerves at ages 18, 20, 22 and 25 days was conducted to identify the period of myelination. Luxol Fast Blue G stain was used to identify the myelin. Myelin, is poorly identified at 18 days but notably present at 25 days. The assays of the phospholipids, expressed as relative percent of the total phospholipid phosphorus, indicated that ethanolamine-phosphoglyceride ratio increases significantly from 17 days to 23 days from onset. Sphingomyelin ratio also increased during this time, but not as much. While the relative amount of serinephosphoglyceride remained constant and ...
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Acer3 upregulation is important for the homeostasis of complex sphingolipid in aging brain.A and B. Levels of individual monohexosylceramide (HexCer) species an
OGT2378 is a GCS inhibitor (Glucosyl Ceramide Synthase Inhibitor) with potential anticancer activity. In murine models with melanoma, OGT2378 decreased tumor size, and showed no cytotoxic and apoptotic effects on MEB-4 melanomacells. Additionally, it has been reported that OGT2378 is biologically active, and a well tolerated agent in in vivo system.
OTX2 Monoclonal Antibody from Invitrogen for Western Blot, Immunofluorescence, Immunocytochemistry, Immunohistochemistry and Flow Cytometry applications. This antibody reacts with Human samples. Clone: 1H12C4B5. Supplied as 100 µL unpurified antibody in ascites with 0.03% sodium azide.
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Metachromatic Leukodystrophy (MLD) is a rare autosomal recessive disorder caused by the deficiency of the Arylsulfatase A enzyme (ARSA), resulting in accumulation of galactosyl sulfatide (cerebroside sulfate), a major constituent of the myelin sheath. Accumulation of galactosyl sulfatides leads to a progressive degeneration of the white matter in the central and peripheral nervous system (CNS, PNS) and neuronal degeneration. The late infantile form of MLD, which usually is diagnosed in the second year of life, is the most frequent and severe form of the disease. The prognosis is severe, leading to vegetative stage or death within few years after the diagnosis. There is no treatment for patients affected with this early onset form of the disease. In patients with late-onset MLD (juvenile and adult forms), allogeneic hematopoietic stem cell transplantation can stabilize the cerebral demyelination. This treatment is however inefficient in patients with late infantile MLD at a symptomatic stage. The ...
Gauchers disease [DOID:1926]. A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver.. Synonyms: Gauchers disease, DOID:1926, Gauchers disease, Gauchers disorder, Gauchers syndrome .... Linkouts: OMIM #1 #2 #3 #4 #5 #6. ...
Sphingolipids, or glycosylceramides, are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological Sphinx because of their enigmatic nature. These compounds play important roles in signal transmission and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with an R group consisting of a hydrogen atom only is a ceramide. Other common R groups include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids. The long-chain bases, sometimes simply known as sphingoid bases, are the first non-transient products of de novo sphingolipid synthesis in both yeast and mammals. These compounds, specifically known as ...
Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. A deficiency is associated with metachromatic leukodystrophy, an autosomal recessive disease. Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine. GRCh38: Ensembl release 89: ENSG00000100299 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000022620 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Stein C, Gieselmann V, Kreysing J, Schmidt B, Pohlmann R, Waheed A, Meyer HE, OBrien JS, von Figura K (January 1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252-9. PMID 2562955. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). "Enzyme replacement improves nervous system pathology and function in a mouse ...
Causes:. A deficit of the enzyme glucocerebrosidase is the cause of Gauchers disease. Normally, this enzyme breaks down glucocerebrosides, which are fatty substances (lipids). However, these fatty substances could build up in someones brain and other organs and within the bone marrow in case the enzyme is scarce. Autosomal recessive is the inheritance pattern via which Gauchers disease is passed along. In order for a child to have the condition, both parents have to be carriers of a Gauchers genetic mutation. So far, more than 300 genetic mutations have been associated with this disease. Theres still only a 25% chance that the child will develop the disease even when both parents are carriers. Theres also a 25% chance that the child will not be a carrier and not have the disease, and a 50% chance that the child will be an unaffected carrier ...
Types A and B appear most often in Jewish families. Type C affects all ethnic groups and is the most common. Ataxia and dystonia are followed by supranuclear vertical gaze palsy, seizures, and dementia. Hepatosplenomegaly often coexists. Foamy (lipid-laden) cells or "sea-blue histiocytes" in the liver and bone marrow are diagnostic. Metachromatic Leukodystrophy (Arylsulfatase A or Saposin B Deficiency) Deficiency of arylsulfatase A or its activator, saposin B, leads to accumulation of cerebroside sulfate, which causes progressive (frontal-predominant) central and peripheral demyelination. ADHD affects about 5% of school-aged children worldwide, predominantly males (3:1 to 8:1). About one-third of ADHD cases have at least one ADHD parent. The risk to first-degree relatives of affected individual is 8-10 times that of the general population. ADHD persists into adolescence in about 30%-50% of affected individuals. The DSM-IV-TR distinguishes two dimensions in the behavior of individuals with ADHD: ...
Looking for online definition of galactosylceramide in the Medical Dictionary? galactosylceramide explanation free. What is galactosylceramide? Meaning of galactosylceramide medical term. What does galactosylceramide mean?
Gauchers Disease* This disease was first described in the year 1882 by a French physician, Dr. Philippe C.E. Gaucher. As per him this disease or disorder takes place due to Accumulation of a particular lipid. Gaucher disease is basically defined as an inherited metabolic disorder (caused due to defective gene for the enzyme glucocerebrosidase from both parents) that leads to the accumulation of a particular fatty substance through out the body. Due to the accumulation of lipids in the body, it results in to deficiency of a particular enzyme acid beta-glucocerebrosidase which is necessary for the breakdown of a particular lipid- glucosyl ceramide. As the lipid accumulates, the glucosyl ceramide gets stored in macrophages (the scavenges cells of the body), which takes up characteristic appearance unique to those affected with this disorder (Gaucher Cells - basically termed as). These lipids get accumulated in the spleen, liver, bone marrow, brain and the lungs. Basically there are three types of ...
Although previous reports have demonstrated that dietary glucosylceramide can decrease TEWL from human skin [24], the mechanism was unclear. Ueda et al. reported that orally administrated ceramide was distributed to the dermis after intestinal absorption, followed by transfer from the dermis to the epidermis [25]. Ishikawa et al. also showed that dietary glucosylceramide was degraded into sphingoids, which were absorbed through the intestinal epithelial cells of rats and were subsequently also found in the lymph fluid in these rats [11]. Another study showed that 4-hydroxysphinganine could activate the PPARs [26] that are the key regulators of keratinocyte differentiation [27].. Keratinocyte differentiation is closely related to internal ceramide synthesis [28]. It is unlikely that orally ingested glucosylceramide would specifically localize to the skin because the amount of ingested glucosylceramide is simply too little to enhance ceramide levels in the skin. We hypothesized that sphingoids are ...
Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
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Detailed step-by-step protocols for all procedures are available on request (barres{at}stanford.edu).. Reagents. Recombinant human trophic factors were obtained from Peprotech (bFGF), Cambridge Neuroscience (GGF2), Regeneron (CNTF), and R & D Systems (Minneapolis, MN; LIF). Monoclonal antibodies were obtained from Serotec (Indianapolis, IN; MRC-OX7 anti-Thy1.1 IgG antibody), American Type Culture Collection (Rockville, MD; A2B5), Jim Cohen (C5 neuroepithelial antibody), Developmental Hybridoma Bank (RAT401 anti-nestin antibody), Sigma (St. Louis, MO; anti-S100β antibody), Barbara Ranscht [Rmab anti-galactocerebroside (anti-GC) antibody], Ursula Drager (R5 anti-vimentin antibody), and Boehringer Mannheim [Indianapolis, IN; anti-5-bromo-2′-deoxyuridine (BrdU) antibody]. Polyclonal antibodies were obtained from Babco (Richmond, CA; rabbit anti-Pax2 antiserum) and Dako (Carpinteria, CA; rabbit anti-GFAP antiserum).. Preparation of optic nerve cell suspension. Sprague Dawley rats (Simonson Labs) ...
Novel, optically active azido alcohols are synthesized from N-haloacetyl oxazolidinone and are coupled with protected, activated carbohydrate residues in stereoselective glycosidic fashion to provide glycolipids in substantially pure stereochemical form. In accordance with certain preferred embodiments, the glycosphingolipids globotriaosylceramide, lactosyl ceramide, and galactosyl ceramide are synthesized in substantially pure stereochemical form from alkenyl, C-18 azido alcohols and protected fluoroglycosides and are employed as antigens in the production of antibodies useful, for example, in the treatment of disease.
Involved in the production of sphingolipid metabolites. Active on sphingosine, phytosphingosine (PHS, 4-hydroxysphinganine), D-erythro-dihydrosphingosine, D-erythro-sphingosine and trans-4, trans-8-sphingadienine, an LCB found exclusively in plants, but not on N-acetyl-dihydrosphingosine (C2-dihydroceramide) and D-threo-dihydrosphingosine.
Summary The study of Gauchers disease-Market Insights, Epidemiology and Market Forecast-2023-United States is very important to enhance business producti
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Definition of globoid cell in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is globoid cell? Meaning of globoid cell as a finance term. What does globoid cell mean in finance?
Synonyms for Acute cerebral Gaucher's disease in Free Thesaurus. Antonyms for Acute cerebral Gaucher's disease. 3 words related to Gauchers disease: monogenic disease, monogenic disorder, lipidosis. What are synonyms for Acute cerebral Gaucher's disease?
Sphingosine-1-phosphate and its receptors may be involved in vascular smooth muscle cell (VSMC) proliferation following vascular injury. Here, we evaluate the effect of d-erythro-N,N-dimethylsphingosine (DMS), a sphingosine kinase (SK) inhibitor, on VSMC proliferation, apoptosis and neointimal formation. Growth responses in vitro to fetal calf serum (FCS) were measured by [3H]-thymidine incorporation and extracellular signal-regulated kinase-1/2 (ERK-1/2) activation in quiescent primary cultures of porcine VSMC in the presence and absence of various concentrations of the SK inhibitor DMS. In vivo treatment with DMS was delivered with a local endoluminal catheter, following balloon injury of coronary arteries. The artery intimal formation was investigated by angiography, myography and histomorphometry. In vitro experiments indicated that DMS induced a dose-dependent reduction in [3H]-thymidine incorporation and ERK-1/2 activation via a protein kinase C (PKC) independent mechanism with an IC50 ...
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The mechanism of membrane domain formation was investigated through analysis of domains induced both by calcium and myelin basic protein in vesicles containing components normally enriched in myelin. In the presence of calcium or myelin basic protein, domains enriched in phosphatidic acid, phosphatidylserine, galactocerebroside, and sulfatide were observed to form. In these domains phosphatidic acid or phosphatidylserine co-localized with galactocerebroside and sulfatide. Sphingomyelin was unable to partition into a domain unless sulfatide was also present ...
Gaucher (pronounced go-SHAY) disease is an inherited illness caused by a gene mutation. Normally, this gene is responsible for an enzyme called glucocerebrosidase that the body needs to break down a particular kind of fat called glucocerebroside. In people with Gaucher disease, the body is not able to properly produce this enzyme and the fat cannot be broken down. It then accumulates, mostly in the liver, spleen and bone marrow.
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WASHINGTON -- A second company has been given an FDA go-ahead to market an as-yet-unapproved drug to treat Gauchers disease, helping to remedy a shortage of the only agent approved for the condition.
Rouser, G., G. Kritchevsky, A. N. Siakotos and A. Yamamoto, in "An Introduction to Neuropathology: Methods and Diagnosis," C. G. Tedeschi, editor, Little, Brown and Co., in press.Google Scholar ...
Page contains details about β-galactosidase/ZIF-8 MOF coating . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Oleamide works as a health promoting, calming dietary supplement. Its great for improving sleep and promoting a restful, relaxed state. Learn more here!
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|p|Gauchers disease is an inherited storage disease caused by a deficiency of the enzyme glucocerebrosidase. Although the hepatic manifestations are seen frequently, pulmonary and cardiovascular involvements are known to be very rare in Gauchers disease. This report presents these rare findings made by conventional radiography, computerized tomography (CT), and High-resolution CT (HRCT) of a 16-year-old female patient with fatal Gauchers disease.|/p|
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While supercritical fluid chromatography (SFC) has been available for decades, very few labs have chosen to take advantage of its remarkable chromatographic properties. The separation of isomeric compounds that are usually challenging for high.performance liquid chromatography (HPLC) can be accomplished by SFC. Coupling the exceptional chromatographic properties of SFC with the sensitivity of mass spectrometric detection results in a powerful piece of equipment that very few laboratories have utilized. Glycosphingolipids (GSLs) are characteristic components of eukaryotic cells, found in the carbohydrate-rich cell membrane. They represent hundreds of diverse chemical structures composed of different carbohydrate and ceramide moieties. The simplest hexosylceramides (HexCer), which are neutral GSLs, are represented by glucosylceramide (GluCer) and galactosylceramide (GalCer). GluCer and GalCer undergo their own distinctive metabolic pathways that effect different biological responses. GSL ...
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TY - JOUR. T1 - Clinical, pathological, and biochemical studies on an infantile case of sulfatide/G(M1) activator protein deficiency. AU - Wenger, D. A.. AU - DeGala, G.. AU - Williams, C.. AU - Taylor, H. A.. AU - Stevenson, R. E.. AU - Pruitt, J. R.. AU - Miller, J.. AU - Garen, P. D.. AU - Balentine, J. D.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - A 28-month-old black male died with severe complications of mental and motor deterioration, seizures, and aspiration. Autopsy demonstrated moderate liver enlargment, normal spleen and kidneys, small testes, and a grossly normal brain. Further examination showed irregular macrogyrae with evidence of a storage or sclerotic process. Thin layer chromatography of the lipids in formalin-fixed tissue demonstrated elevated levels of ceramide trihexoside and possibly sulfatides in liver and a decrease in the ratio of galactosylceramide to sulfatide in brain. Examination of the gangliosides in formalin-fixed brain indicated a slight increase in the percentage of ...
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Prof. Tony Futermans lab in the Department of Biological Chemistry has recently discovered a new cellular pathway implicated in Gaucher disease which may offer a new therapeutic target for the disease and related disorders. Gaucher disease is a genetic disorder most prevalent among the Ashkenazi Jewish population. It is caused by a defect in a particular enzyme needed to break down a fatty substance, or lipid, called glucocerebroside. This results in the accumulation of the lipid in various cells and organs, stymieing their function. The most common form, Type 1, is characterized by swelling, enlargement, and dysfunction of the spleen and liver, along with lung and bone problems. People with Types 2 and 3 Gaucher disease suffer from these symptoms and also have neurological symptoms; Type 2 - the most severe form - causes extensive brain damage and death before two years of age. Type 3 is a more progressive form of the disease that affects the brain, with patients often living into their early teens
The results of this study are consistent with the following conclusions. First, unconjugated β-galactosidase is rapidly cleared from blood in vivo (Table 2), owing to rapid uptake of the unconjugated enzyme by liver and spleen (Figs. 2 and 3). Second, once inside cells, β-galactosidase is rapidly degraded in vivo such that 99% of the organ enzyme activity is lost at 4 h after an intravenous injection (Table 1). Third, the 116-kDa β-galactosidase (Fig. 1B) can be conjugated to the 8D3 TfRmAb without loss of enzyme activity (Fig. 1C). Fourth, there is minimal brain uptake of the unconjugated β-galactosidase, but there is a 10-fold increase in brain uptake of enzyme following conjugation to the 8D3 TfRmAb (Table 1; Figs. 2 and 3).. The β-galactosidase is rapidly removed from the blood due to the avid uptake of the enzyme by liver and spleen (Figs. 2 and 3), which confirms the earlier observation of Onodera et al. (1983). The blood concentration of the β-galactosidase-TfRmAb is 5- to 10-fold ...
Page contains details about β-galactosidase expressing plasmid encapsulating liposomes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Edvotek 300 kit shows how to clone a DNA fragment by using ligation, transformation and an assay of ß-galactosidase. For advanced students.
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A test may help to diagnose Gaucher disease early in life and differentiate its subtypes by measuring blood levels of glucosylsphingosine, a study says.
Definition of galactosyl - A radical or group derived from galactose by loss of a hydroxyl group. Usually attributive or as a formative element in names of c
Molecular Cloning, also known as Maniatis, has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential.
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Globoid cell leukodystrophy (GLD) or Krabbe disease, is a fatal demyelinating disease attributed to mutations in the galactocerebrosidase (GALC) gene. Loss of function mutations in GALC result in accumulation of the glycolipid intermediate, galactosylsphingosine (psychosine). Due to the cytotoxicity of psychosine, it has been hypothesized that accumulated psychosine underlie the pathophysiology of GLD. However, the cellular mechanisms of GLD pathophysiology remain unclear. Globoid cells, multinucleated microglia/macrophages in the central nervous system (CNS), are a defining characteristic of GLD. Here we report that exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase (MMP)-3 that mediated a morphological transformation of microglia into a multinucleated globoid cell type. Additionally, psychosine-induced globoid cell formation from microglia was prevented by either genetic ablation or chemical inhibition of MMP-3. These effects are
Two adult siblings with biochemically and histologically documented Gauchers disease as well as a similar diffuse neurologic disorder are presented. The family history suggests that a third, deceased sibling also had a similar neurologic disorder associated with Gauchers disease. There have been no previous reports of a similar neurologic disorder in adult-type Gauchers disease. ...
Synonyms: globoid cell leukodystrophy, globoid cell leukoencephalopathy, galactosylceramide lipidosis, galactosylceramidase (GALC) deficiency This is an...
... (MLD) is a rare genetic condition that causes a buildup of a specific type of fat (sulfatides) in brain and spinal cord cells. This buildup causes leukodystrophy, which is progressive destruction of cells that have a myelin coating (white matter) in the brain and spinal cord. Destruction of these cells leads to the inability to think clearly and perform physical tasks. Individuals with MLD lose the ability to perform daily functions over time, such as talking and walking. As the disease progresses, individuals lose awareness of where they are and eventually become unresponsive. Blindness, seizures and hearing loss may also occur. There are three forms of MLD: late infantile form, juvenile form, and adult form. The late infantile form, which is the most common form, begins in the second year of life and progresses rapidly. The juvenile form typically begins between 4 years of age and teenage years, while the adult form starts after the teenage years.. MLD, which is an ...
Gaucher disease is caused by an inherited deficiency of glucocerebrosidase that manifests with storage of glycolipids in lysosomes, particularly in macrophages. Available cell lines modeling Gaucher disease do not demonstrate lysosomal storage of glycolipids; therefore, we set out to develop two macrophage models of Gaucher disease that exhibit appropriate substrate accumulation. We used these cellular models both to investigate altered macrophage biology in Gaucher disease and to evaluate candidate drugs for its treatment. We generated and characterized monocyte-derived macrophages from 20 patients carrying different Gaucher disease mutations. In addition, we created induced pluripotent stem cell (iPSC)-derived macrophages from five fibroblast lines taken from patients with type 1 or type 2 Gaucher disease. Macrophages derived from patient monocytes or iPSCs showed reduced glucocerebrosidase activity and increased storage of glucocerebroside and glucosylsphingosine in lysosomes. These ...
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Define alpha-hydroxy acids. alpha-hydroxy acids synonyms, alpha-hydroxy acids pronunciation, alpha-hydroxy acids translation, English dictionary definition of alpha-hydroxy acids. n. Abbr. AHA Any of various acids, such as citric acid or glycolic acid, that contain a hydroxyl group adjacent to the carboxyl group and are often used in...
TY - JOUR. T1 - Isolation of hydroxy fatty acids from livers of carbon tetrachloride-treated rats by thin-layer chromatography. AU - Bandi, Z. L.. AU - Ansari, G. A.S.. PY - 1989. Y1 - 1989. UR - http://www.scopus.com/inward/record.url?scp=0024358754&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024358754&partnerID=8YFLogxK. U2 - 10.1016/S0021-9673(01)89705-3. DO - 10.1016/S0021-9673(01)89705-3. M3 - Article. C2 - 2777965. AN - SCOPUS:0024358754. VL - 475. SP - 461. EP - 466. JO - Journal of Chromatography A. JF - Journal of Chromatography A. SN - 0021-9673. IS - 2. ER - ...
Looking for alpha-hydroxy acid? Find out information about alpha-hydroxy acid. 1. any substance that dissociates in water to yield a sour corrosive solution containing hydrogen ions, having a pH of less than 7, and turning litmus red... Explanation of alpha-hydroxy acid
Quantitation of β-galactosidase activity. In yeast cells, co-transformed with pGADT7 (AD) and pGBKT7 (BD) constructs as indicated, β-galactosidase activity wa
NewsThe study results address Gauchers disease.Contributed Author: NYU Langone Medical CenterTopics: Disease Research http://www.dddmag.com/news/2016/10/asthma-research-yields-new-treatment-approach-inherited-enzyme-disease
Alpha galactosidase A Antibody 66121-1-Ig has been identified with IF, IHC, WB, ELISA. 66121-1-Ig detected 49 kDa band in HeLa cells with 1:500-1:2000 dilution...
Alpha galactosidase A Antibody 19877-1-AP has been identified with IF, WB, ELISA. 19877-1-AP detected 49 kDa band in HEK-293 cells with 1:500-1:3000 dilution...
Alpha-complementation of β-galactosidase does not seem to yield activities equal to wildtype β-galactosidase. Depending on the fragment, the activity can be up to 24% of wildtype [5]. (If anyone has a better reference comparing results from a Miller assay of alpha-complementated β-galactosidase with wildtype, please include it here.) ...
Radiant Insights, Inc latest Pharmaceutical and Healthcare disease pipeline guide Metachromatic Leukodystrophy (MLD) - Pipeline Review, H2 2016, provides an overview of the Metachromatic Leukodystrophy (MLD) (Central Nervous System) pipeline landscape. Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. Symptoms include vision problems leading to blindness, personality…
INTRODUCTION. Krabbe disease (DK) is a lysosome deposit disease caused by the deficiency of the enzyme galactocerebrosidase (GALC). It was first described in 1916, when Krabbe reported an uncommon form of familial diffuse brain sclerosis(1). GALC is responsible for the hydrolysis of galactolipids (lipid components of the myelin membrane). The main galactolipids are galactocerebrosides and psychosine(2). Galactocerebrosides are also hydrolyzed by GM1-gangliosidase and do not degrade psychosine; therefore, there is a greater accumulation of this substance. Psychosine is the primary component responsible for the destruction of oligodendrocytes and Schwann cells, which produce myelin, resulting in demyelination of the central and peripheral nervous systems; additionally, it causes activation of astrocytes and the formation of multinucleate globoid cells (macrophages with accumulations of galactocerebrosides), characteristics of the disease in the pathological examination(3).. There are two clinical ...
EC 2.7.1.91. Accepted name: sphingosine kinase. Reaction: ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate. Other name(s): SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Systematic name: ATP:sphingoid base 1-phosphotransferase. Comments: The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.. Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 50864-48-7. References:. 1. Stoffel, W., Heimann, G. and Hellenbroich, B. Sphingosine kinase in blood platelets. ...
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Allcosmeticsource.com alpha galactosidase 2000u/g,5kg/bag,free shipping [EP170508006]- alpha galactosidase 2000u/g,1kg/bag,free shipping What is alpha galactosidase 2000u/g alpha galactosidase is an enzyme used to hydrolyze or break α-1, 6-glycosidic bonds into galactosyl oligosaccharides (α-galactosides), liberating simpler, more usable sugars and eliminating its anti-nutrient effect. Thus, it improves the utilization of the energy and proteins in feedstuff. Function of alpha galactosidase 2000u/g Hydrolyzing
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Looking for Gaucher's? Find out information about Gaucher's. rare genetic disease involving a deficiency of an enzyme, glucocerebrosidase, which normally breaks down certain body glycolipids . There are three types of... Explanation of Gaucher's
Background The appropriate fatty acids composition of brain lipids is critical for functioning of this organ. The alterations of brain fatty acids composition may lead to neurological and...
Often your arrival here comes at a time of great personal trauma due to a recent diagnosis or encounter with MLD. We want you to know that you can count on us for support, information and to help you get connected with others who are also on the MLD journey.. ...
Gaucher Disease is the most prevalent lysosomal glycolipid storage disorder, and is caused by an acid beta galactosidase deficiency. Symptoms of Gaucher Disease, which range from mild to severe, are a result of the accumulation of a fatty substance (lipid) called glucocerebroside in bone marrow cells. The most common symptoms include an enlarged spleen, an enlarged liver, frequent nosebleeds, anemia, poor blood clotting, and a reduced blood platelet count.
This unit describes fixation and staining for b‐galactosidase activity; it has been successfully used on vertebrate embryos and tissue explants
N-Hexanoyl-NBD-glucosylceramide, Fluorescent C6:0-glucosylceramide analog, with |98% purity. Join researchers using our high quality biochemicals.
Several types of assays can be performed measuring galactosidase activity in yeast using 5-Bromo-4-chloro-3-indoxyl-α-D-fucopyranoside as subtrate.
O-Nitrophenyl-β-D-Galactopyranoside (ONPG) Test. The objective of ONPG is to determine the ability of an organism to produce β-galactosidase.
Metachromatic leukodystrophy. Metachromatic leukodystrophy (MLD) is an autosomal recessive inherited disorder in which the desulfation of 3-0-sulfogalactosyl-containing glycolipids by arylsulfatase A (ASA) is defective. The clinical onset and severity of MLD is variable. The late infantile form typically presents in the second year of life, the juvenile form presents between age 4 and puberty, and the adult form may present at any age after puberty. Gait disturbance and mental regression are the earliest signs. Depending on the variant, other symptoms include blindness, seizures, and behavioral disturbances. Diagnosis of MLD is complicated by the fact that significant reduction of ASA activity may not prove MLD and that its presence does not exclude it. Significant reduction of ASA activity is observed in individuals homozygous for the pseudodeficiency allele. Normal ASA activity is observed in MLD patients with a deficiency of saposin B. Residual activity can be detected in patients with late ...
Glucocerebrosidase (GCase) is an important enzyme for the metabolism of glycolipids. GCase enzyme deficiency is implicated in human disease and the efficient measurement of GCase activity is important for evaluating the efficacy of therapeutics targeting this enzyme. Existing approaches to measure GCase activity include whole blood mass spectrometry-based assays, where an internal standard is used to measure the accumulation of ceramide following metabolism of the synthetic substrate C12-glucocerebroside, and the utilisation of fluorescent probes that bind active GCase and/or release fluorescent metabolites upon cleavage by GCase. Here, we describe the application of a fluorescence-activated cell sorter-based assay to efficiently quantitate GCase enzyme activity in the monocyte population of human peripheral blood mononuclear cells. The cell-permeable GCase substrate 5-(Pentafluorobenzoylamino) Fluorescein Di-beta-D-Glucopyranoside (PFB-FDGlu) provides a means to measure GCase activity, whereby
TY - JOUR. T1 - Study on the nature of starfish larval muscle cells in vitro. AU - Kaneko, Hiroyuki. AU - Kawahara, Yukio. AU - Okamoto, Mitsumasa. AU - Dan-Sohkawa, Marina. PY - 1997/4. Y1 - 1997/4. N2 - We describe a culture method in which larval muscle cells of the starfish Asterias amurensis develop from epithelial cells, probably deriving from the coelomic pouches. The nature of the muscle which appears in the culture is described morphologically, physiologically and ultrastructurally. Cells were dissociated from the late gastrula stage, treated with 0.6 M of glycine in half-strength sea water free of Ca2+ and Mg2+ for 12 hr, and cultured for various periods. Elongated cells appeared after about a week from small aggregates of epithelial cells which were found among the mesenchymal network on the 1st day of culture. The characteristics of the elongated cells are as follows: (1) they possess two or more arms; (2) they adhere to the cultural substratum, mesenchyme cells, and themselves at ...
This Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free) is validated for use in Western Blotting, Immunoprecipitation, Flow Cytometry for the detection of mouse Integrin alphaV. Find MSDS or SDS, a COA, data sheets and more information.
Colorectal liver metastasis is clinically a major problem. We examined the antitumor activity of KRN7000, an α-galactosylceramide, on mice with liver metastases of adenocarcinoma Colon26 cells. KRN7000 treatment, beginning 1 day after tumor inoculation (day 1), significantly inhibited tumor growth in the liver, and its potency was equal to that of interleukin 12. KRN7000 treatment from day 3 caused regression of established Colon26 nodules. KRN7000 administration resulted in a high percentage of cured mice that acquired tumor-specific immunity. In addition, it appeared that highly activated, liver-associated natural killer cells made the major contribution to the killing of Colon26 cells in the liver. These results suggest that KRN7000 may be useful for the treatment of colorectal liver metastasis.. ...
Unexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC-205+ dendritic cells (DCs) and NK1.1+ invariant natural killer T (iNKT) cells are recruited into the myometrium of mice when miscarriage is induced by the intraperitoneal administration of α-galactosylceramide (α-GalCer). Here we demonstrate that the adoptive transfer of DEC-205+ bone marrow-derived DCs cocultured with α-GalCer (DEC-205+ BMDCs-c/w-α-GalCer) directly induced marked fetal loss by syngeneic pregnant C57BL/6 (B6) mice and allogeneic mice (B6 (♀) × BALB/c (♂)), which was accompanied by the accumulation of activated iNKT cells in the myometrium ...
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Configuration of cerebrosides. J. Biol. Chem. 221: 879-884. Carter, H. E., C. P. Schaffner, and D. Gottlieb. 1954. Levomycin. I ... Structure of the cerebrosides. J. Biol. Chem. 199: 283-288. Carter, H. E., D. Gottlieb, and H. W. Anderson. 1948. Chloromycetin ...
Cerebrosides have a single glucose or galactose at the 1-hydroxy position. Sulfatides are sulfated cerebrosides. Gangliosides ... yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids. ...
MLD involves cerebroside sulfate accumulation. Metachromatic leukodystrophy, like most enzyme deficiencies, has an autosomal ...
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". ... Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. ... Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694 ...
Purification and Properties of a Cerebroside Transfer Protein. Journal of Biological Chemistry. 1982;257(21):12901-07. PMID ...
Specifically, cerebroside sulfotransferase (CST) is elevated as it passes along a signaling pathway which involves: hepatocyte ... This reaction is catalyzed by cerebroside sulfotransferase (CST). CST is a homodimeric protein that is found in the Golgi ... In peripheral nerves that are cerebroside sulfotransferase (CST) deficient, the nodes of Ranvier form enlarged axonal ... Consequently, the COS-7 cells were transfected with galactosyltransferase and cerebroside sulfotransferase genes from the Madin ...
... s A-H are neuritogenic cerebrosides isolated from the mushroom Termitomyces albuminosus. Termitomycesphins G ... and H, additional cerebrosides from the edible Chinese mushroom Termitomyces albuminosus. ...
Fujino Y, Nakano M (1969). "Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose". Biochem. J. 113 ...
His proposals on the biosynthesis and degradation of cerebroside-3-sulfate, a lipid found in high concentrations in patients ... Bimal K Bachhawat; James Austin; Donald Armstrong (1967). "A Cerebroside Sulphotransferase Deficiency in a Human Disorder of ... Farooqui, Bachhawat B. K. (1973). "Enzymic desulfation of cerebroside-3'-sulfate by chicken brain arylsulfatase". J. Neurochem ... B. K. (1965). "Formation of cerebroside sulfate from 3'-phosphoadenosine-5'phosphosulfate in sheep brain". Biochim. Biophys. ...
Plasma membranes also contain carbohydrates, predominantly glycoproteins, but with some glycolipids (cerebrosides and ...
It is found in wood tar, various cerebrosides, and in small amounts in most natural fats. The fatty acids of peanut oil contain ...
1991). "The organization of the gene for the human cerebroside sulfate activator protein". FEBS Lett. 280 (2): 267-70. doi: ... 1990). "The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein ...
... (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose. ...
A glycosphingolipid that has only one sugar as the side chain is called a cerebroside. The side chain can be cleaved by ...
Morell P, Radin NS (1969). "Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing ...
Jurevics, H; Hostettler, J; Muse, ED; Sammond, DW; Matsushima, GK; Toews, AD; Morell, P (May 2001). "Cerebroside synthesis as a ... Glycosphingolipids are mostly located in nervous tissue and are responsible for cell signaling.Cerebrosides: a group ... a type of cerebroside with glucose as the saccharide moiety; often found in non-neural tissue. Sulfatides: a class of ...
The simplest glycolipid is cerebroside, in which there is only one sugar residue, either Glc or Gal. More complex glycolipids, ...
1990). "The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein ...
At this time, [35S] Sulfate was incorporated into sulfatide and the activity of cerebroside, sulfotransferase reached a peak in ... In conclusion, the early phase of myelination was correlated with the increases synthesis of lipids, cholesterol, cerebroside, ... cerebroside, and sulfatide. As researchers began to do postnatal research, they found that myelinogenesis in the rat optic ...
... (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into ... cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. A deficiency is associated with metachromatic ...
Other names in common use include GSase, 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase, galactocerebroside ...
A galactocerebroside (or galactosylceramide) is a type of cerebroside consisting of a ceramide with a galactose residue at the ...
... s include: Cerebrosides Gangliosides Globosides Gangliosides are mainly found in the cell membranes of the ... In the case of cerebrirosis, this affects the cerebrosides (examples are Gaucher's disease and Krabbe's disease), in case of ...
... cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26". Genomics. 34 (1): 69-75. doi ...
... cerebrosides MeSH D09.400.410.420.525.200.250.450 --- galactosylceramides MeSH D09.400.410.420.525.200.250.490 --- ...
MLD involves cerebroside sulfate accumulation. Metachromatic leukodystrophy, like most enzyme deficiencies, has an autosomal ...
... cerebroside sulfate), a major constituent of the myelin sheath. Accumulation of sulfatides leads to a progressive degeneration ...
... where they may interdigitate with adjacent intercellular cerebrosides or with covalently bound cerebrosides. (Less). Links. * ... cerebroside, desert, mesic, covalently bound lipid. in Journal of Experimental Biology. volume. 215. issue. 24. pages. 4299 - ... where they may interdigitate with adjacent intercellular cerebrosides or with covalently bound cerebrosides.}, author = { ... we found that covalently bound cerebrosides correlated positively with intercellular cerebrosides and intercellular cholesterol ...
cerebroside* Any one of a class of glycolipids [1] in which a single sugar unit is bound to a sphingolipid (see phospholipid [2 ... cerebroside Any one of a class of glycolipids in which a single sugar unit is bound to a sphingolipid (see phospholipid). The ... cerebrosides A Dictionary of Food and Nutrition © A Dictionary of Food and Nutrition 2005, originally published by Oxford ... cerebroside A Dictionary of Biology © A Dictionary of Biology 2004, originally published by Oxford University Press 2004. ...
... is a ceramide (CHEBI:17761) cerebroside (CHEBI:23079) is a neutral glycosphingolipid (CHEBI:25513) ... HexCer(d37:2) (CHEBI:138902) is a cerebroside (CHEBI:23079). hexosyl-(1↔1ʼ)-N-acylsphingosine (CHEBI:82917) is a cerebroside ( ... HexCer(d32:1) (CHEBI:138900) is a cerebroside (CHEBI:23079). HexCer(d33:2) (CHEBI:138901) is a cerebroside (CHEBI:23079). ... N-tetracosanoyl hexosylceramide (CHEBI:77463) is a cerebroside (CHEBI:23079). galactosylceramide (CHEBI:36498) is a cerebroside ...
... or cerebroside sulfatase. Arylsulfatase A deficiency allows certain harmful sulfur-containing lipids, known as ... called arylsulfatase A (ASA), or cerebroside sulfatase. Arylsulfatase A deficiency allows certain harmful sulfur-containing ...
cerebroside synonyms, cerebroside pronunciation, cerebroside translation, English dictionary definition of cerebroside. n. Any ... cerebroside. Also found in: Medical, Encyclopedia, Wikipedia.. Related to cerebroside: ganglioside. cer·e·bro·side. (sĕr′ə-brə- ... IFB-121 * Cerebroside 1 * Cerebroside 2 Phornopsis sp.. Endophytic fungi--the treasure chest of antibacterial substances ... Cerebroside - definition of cerebroside by The Free Dictionary https://www.thefreedictionary.com/cerebroside ...
"Fatty acid composition of cerebrosides and cerebroside sulphatides in cerebral oedema". Acta Neuropathologica. 12 (1): 62-67. ... Cerebroside molecules are able form up to eight intermolecular hydrogen bonds between the polar hydrogens of the sugar and the ... Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves. These ... Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. The sugar moiety is linked ...
Cerebroside-sulfatase (EC 3.1.6.8, arylsulfatase A, cerebroside sulfate sulfatase) is an enzyme with systematic name ... Arylsulfatase A Cerebroside-sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... This enzyme catalyses the following chemical reaction a cerebroside 3-sulfate + H2O ⇌ {\displaystyle \rightleftharpoons } a ... cerebroside + sulfate This enzyme hydrolyses galactose-3-sulfate residues in a number of lipids. Mehl, E.; Jatzkewitz, H. (1964 ...
What is cerebroside-sulfatase? Meaning of cerebroside-sulfatase medical term. What does cerebroside-sulfatase mean? ... Looking for online definition of cerebroside-sulfatase in the Medical Dictionary? cerebroside-sulfatase explanation free. ... cerebroside-sulfatase. cer·e·bro·side-sul·fa·tase. , cerebroside sulfatidase. an enzyme that cleaves sulfate from a sulfated ... A gene on chromosome 22q13.31-qter that encodes arylsulfatase A, which hydrolyses cerebroside sulfate to cerebroside and ...
... ceramide beta-D-galactoside This cerebroside product is a glycosphingolipid containing a galactose (galactocerebroside) ... Scientific Name:Cerebrosides, bovine. *Common Name:Galactosylceramide; Ceramide beta-D-galactoside (contains both hydroxy and ... This cerebroside product is a glycosphingolipid containing a galactose (galactocerebroside) attached to a ceramide acylated ... This leads to an accumulation of cerebroside and psychosine (which is very cytotoxic and can result in demyelination of nerves ...
Cerebroside antibody binding activity was only partially blocked by 0.5 M galactose or α- and β-methylgalactopyranoside, ... Abstract A natural cerebroside (antiC) IgM antibody was found at relatively high levels in the serum of every healthy ... A natural cerebroside (antiC) IgM antibody was found at relatively high levels in the serum of every healthy individual studied ... Cerebroside antibody binding activity was only partially blocked by 0.5 M galactose or α- and β-methylgalactopyranoside, ...
The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from ... And the cerebroside was also reported to regulate lipid levels according to Cohn Jeffrey [24]. The marine cerebroside displayed ... Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. *Bei Zhang1. , ... Gao Z, Zhou X, Hu XQ, Xue CH, Xu J, Wang YM: Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose ...
Structure of Cerebrosides. II. Small Angle X-Ray Diffraction Study of Cerasine. Hosemann, R. / Loboda-Čačković, J. / Čačković, ...
... cerebroside explanation free. What is cerebroside? Meaning of cerebroside medical term. What does cerebroside mean? ... Looking for online definition of cerebroside in the Medical Dictionary? ... cerebroside. Also found in: Dictionary, Encyclopedia, Wikipedia.. Related to cerebroside: ganglioside. cerebroside. [sĕ-re´bro- ... The sulfate esters of cerebrosides are among the sulfatidates.. cerebroside. /cer·e·bro·side/ (ser´ĕ-bro-sīd″) a general ...
Which of the following types of compounds are glycoproteins? a. cerebrosides b. gangliosides c. immunoglobins d.... Organic And ...
Mitteilung über Cerebroside. Klenk, E. / Leupold, F. Page 208. Published Online: 10/15/2009 ...
Cerebrosides. 0.5. Cholesterol. 0.5. Source: Principles of Meat Science by Forrest et al. (1975) W.H. Freeman & Co. ...
... cerebrosides; dicetylphosphate; dipalmitoylphosphatidylglycerol; stearylamine; dodecylamine; hexadecyl-amine; acetyl palmitate ...
Structure of Cerebrosides I. Phrenosine at 23 °C and 66 °C. Fernandez-Bermudez, S. / Loboda-Čačković, J. / Čačković, H. / ...
... cerebrosides; (4) PE; (5) PC; (6) phosphatidylserine plus phosphatidylinositol.O, Origin. ...
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Vesicular transport of myelin proteolipid and cerebroside sulfates to the myelin membrane. J. Neurosci. Res. 35, 402 - 408. * ... and its sulfated form cerebroside sulfate (CBS), and cholesterol (Norton 1977). It has a complex structure as it contains ...
Fingerprint Dive into the research topics of A model system for opiate-receptor interactions: Mechanism of opiate-cerebroside ... A model system for opiate-receptor interactions: Mechanism of opiate-cerebroside sulfate interaction. ...
glucosyl cerebroside lipidosis. *glucosylceramidase deficiency. *glucosylceramide beta-glucosidase deficiency. * ...
  • Our results led us to propose a new model for the organization of lipids in the avian SC, in which the sugar moieties of cerebrosides lie outside of intercellular lipid layers, where they may interdigitate with adjacent intercellular cerebrosides or with covalently bound cerebrosides. (lu.se)
  • Although covalently bound lipids in larks did not correlate with CWL, we found that covalently bound cerebrosides correlated positively with intercellular cerebrosides and intercellular cholesterol ester, and intercellular cerebrosides correlated positively with covalently bound free fatty acids. (lu.se)
  • The most consistent pattern that emerged was a decrease in the relative amount of cerebrosides as CWL increased, a pattern that is counterintuitive based on studies of mammals with Gaucher. (lu.se)