Cerebral Small Vessel Diseases: Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE.Leukoaraiosis: Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS.Brain Infarction: Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.Stroke, Lacunar: Stroke caused by lacunar infarction or other small vessel diseases of the brain. It features hemiparesis (see PARESIS), hemisensory, or hemisensory motor loss.Leukoencephalopathies: Any of various diseases affecting the white matter of the central nervous system.Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Microvessels: The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Nerve Fibers, Myelinated: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.CADASIL: A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)Venules: The minute vessels that collect blood from the capillary plexuses and join together to form veins.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Netherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Cerebral Arteries: The arterial blood vessels supplying the CEREBRUM.Dementia, Multi-Infarct: Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).Basal Ganglia Cerebrovascular Disease: A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (BASAL GANGLIA), such as INFARCTION; HEMORRHAGE; or ISCHEMIA in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (DYSKINESIAS) and muscle weakness (HEMIPARESIS).Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Siderosis: A form of pneumoconiosis resulting from inhalation of iron in the mining dust or welding fumes.Asymptomatic Diseases: Diseases that do not exhibit symptoms.Cerebrovascular Trauma: Penetrating and nonpenetrating traumatic injuries to an extracranial or intracranial blood vessel that supplies the brain. This includes the CAROTID ARTERIES; VERTEBRAL ARTERIES; MENINGEAL ARTERIES; CEREBRAL ARTERIES; veins, and venous sinuses.Vertebral Artery: The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.Cerebral Arterial Diseases: Pathological conditions of intracranial ARTERIES supplying the CEREBRUM. These diseases often are due to abnormalities or pathological processes in the ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; and POSTERIOR CEREBRAL ARTERY.Rest: Freedom from activity.Basal Ganglia Hemorrhage: Bleeding within the subcortical regions of cerebral hemispheres (BASAL GANGLIA). It is often associated with HYPERTENSION or ARTERIOVENOUS MALFORMATIONS. Clinical manifestations may include HEADACHE; DYSKINESIAS; and HEMIPARESIS.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Australasia: Australia, New Zealand and neighboring islands in the South Pacific Ocean. (Random House Unabridged Dictionary, 2d ed.)Cerebral Amyloid Angiopathy: A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Lymphatic System: A system of organs and tissues that process and transport immune cells and LYMPH.Chemokine CXCL12: A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.Receptors, CXCR4: CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.Capillary Leak Syndrome: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Diabetic Ketoacidosis: A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Subarachnoid Space: The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.Extracellular Fluid: The fluid of the body that is outside of CELLS. It is the external environment for the cells.Microdialysis: A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.Receptors, Notch: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Indans: Aryl CYCLOPENTANES that are a reduced (protonated) form of INDENES.Craniocerebral Trauma: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.Cholinesterase Inhibitors: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.World War I: Global conflict primarily fought on European continent, that occurred between 1914 and 1918.Famous PersonsVermontNew HampshireMemantine: AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Autopsy: Postmortem examination of the body.Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Newcastle disease virus: The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.Choline O-Acetyltransferase: An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6.Lewy Bodies: Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.Anisotropy: A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.Vascular Stiffness: Loss of vascular ELASTICITY due to factors such as AGING; and ARTERIOSCLEROSIS. Increased arterial stiffness is one of the RISK FACTORS for many CARDIOVASCULAR DISEASES.Pulsatile Flow: Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Cardiac Imaging Techniques: Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Superoxides: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.Mice, Inbred C57BLMississippiHead Injuries, Closed: Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and dura mater. This frequently results in mechanical injury being transmitted to intracranial structures which may produce traumatic brain injuries, hemorrhage, or cranial nerve injury. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)Wounds, Nonpenetrating: Injuries caused by impact with a blunt object where there is no penetration of the skin.Skull Fracture, Basilar: Fractures which extend through the base of the SKULL, usually involving the PETROUS BONE. Battle's sign (characterized by skin discoloration due to extravasation of blood into the subcutaneous tissue behind the ear and over the mastoid process), CRANIAL NEUROPATHIES, TRAUMATIC; CAROTID-CAVERNOUS SINUS FISTULA; and CEREBROSPINAL FLUID OTORRHEA are relatively frequent sequelae of this condition. (Adams et al., Principles of Neurology, 6th ed, p876)JordanBibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Vascular pathology in the aged human brain. (1/41)

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Diffusion tensor imaging and cognition in cerebral small vessel disease: the RUN DMC study. (2/41)

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Vascular inflammation in cerebral small vessel disease. (3/41)

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Arterial stiffness and cognitive decline in well-functioning older adults. (4/41)

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Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. (5/41)

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The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? (6/41)

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Frontal and temporal microbleeds are related to cognitive function: the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study. (7/41)

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Angiogenic T-cells and putative endothelial progenitor cells in hypertension-related cerebral small vessel disease. (8/41)

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*Lipohyalinosis

... is a cerebral small vessel disease affecting the small arteries, arterioles or capillaries in the brain. ... "The renin-angiotensin-aldosterone system in cerebral small vessel disease". J Neurol. May 2, 2000. ... Fisher considered this small vessel disease to be the result of hypertension, induced in the acute stage by fibrinoid necrosis ... These affect the deep structures of the brain and may leave small (~5mm) cavity lesions. Chronic familial lipohyalinosis is a ...

*Joanna Wardlaw

... particularly cerebral small vessel diseases. She is also interested in the use of imaging in pathophysiology. In 2005 Wardlaw ... "Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging". The Lancet Neurology. 12 (5): 483-497. doi: ... "Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration". The Lancet ... Wardlaw is recognised as an expert in brain blood vessel diseases and neuroimaging. Her current research is focused on the ...

*Perivascular space

Pantoni, Leonardo (2010). "Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic ... Cerebral amyloid angiopathy (CAA), a blood vessel failure often associated with Alheimer's disease, utilizes dilated VRS to ... Dilation is also a common characteristic of diseases or disorders of vascular pathologies, including CADASIL (cerebral ... Dilation is a typical characteristic of several diseases and disorders. These include diseases from metabolic and genetic ...

*Porencephaly

... and cerebral small vessel diseases involving both stroke and infarction. Abnormal gene expression of COL4A1 can contribute to ... The COL4A1 protein provides a strong layer around blood vessels. The mutation can weaken the blood vessels within the brain, ... blood clotting of vessels Cystic periventricular leukomalacia Cerebral atrophy - decrease in neuron number and size and loss of ... abnormal movements of appendages Cerebral palsy - a motor condition causing movement disabilities Blood vascular diseases such ...

*Montreal Cognitive Assessment

... in patients with cerebral small vessel disease". Dementia and Geriatric Cognitive Disorders. 28 (1): 81-87. doi:10.1159/ ... such as Parkinson's disease, vascular cognitive impairment, Huntington's disease, brain metastasis, sleep behaviour disorder, ... people with Alzheimer's disease scored an average of 16.2. Since the MoCA assesses multiple cognitive domains, it may be a ... and Early Alzheimer's disease compared with the well-known Mini-Mental State Examination (MMSE). According to the validation ...

*Microangiopathy

... or large vessel disease. Cerebral small vessel disease refers to a group of diseases that affect the small arteries, arterioles ... or small vessel disease) is an angiopathy (i.e. disease of blood vessels) affecting small blood vessels in the body. It can be ... Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most common forms. Coronary ... Coronary small vessel disease is also known as cardiac syndrome X, microvascular dysfunction, non-obstructive coronary disease ...

*Cerebral atherosclerosis

This small vessel damage can also reduce the clearance of amyloid-β, thereby increasing the likelihood of CAA. Diseases ... cerebral atherosclerosis and associated diseases can cause are: Alzheimer's disease Alzheimer's disease is a form of dementia ... Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of the brain occurs. Some ... The risk of cerebral atherosclerosis and its associated diseases appears to increase with increasing age; however there are ...

*Microinfarct

... which are a result of pathologies involving small vessels. Such pathologies are arteriosclerosis or cerebral amyloid angiopathy ... Microinfarcts may be the second most important cause of dementia, after Alzheimer's disease. Microinfarcts are microscopic ... "Cerebral Microinfarcts: The Invisible Lesions." Lancet Neurology 11.3 (2012): 272-282. PMC. Web. 20 Mar. 2016. Wang M, Iliff JJ ... Microinfarcts - Small Size, Big Impact Archived 2014-09-01 at Archive.is. Hotchkiss Brain Institute. Retrieved September 1, ...

*Stroke

Small vessel disease involves the smaller arteries inside the brain: branches of the circle of Willis, middle cerebral artery, ... Diseases that may form thrombi in the small vessels include (in descending incidence): lipohyalinosis (build-up of fatty ... Diseases that may form thrombi in the large vessels include (in descending incidence): atherosclerosis, vasoconstriction ( ... Two types of thrombosis can cause stroke: Large vessel disease involves the common and internal carotid arteries, the vertebral ...

*Vascular bypass

"Large and Small Vessel Atherosclerosis: Similarities and Differences". Progress in Cardiovascular Diseases. 50 (2): 112-125. ... In the skull, when blood flow is blocked or a damaged cerebral artery prevents adequate blood flow to the brain, a cerebral ... Medical conditions such as ischemic heart disease or chronic obstructive pulmonary disease that increase the risk of surgery ... peripheral vascular disease or coronary artery disease). Some patients start feeling normal after one month, while others may ...

*Charles Foix

Foix-Alajouanine disease, Softening of the grey matter of the spinal cord with obliterative sclerosis of the small vessels. ... Schilder-Foix disease, Nonprogressive sclerotic lesions of the white matter of the cerebral hemisphere. Charles Foix @ Who ... Foix's syndrome II, Ophtalmoplegic disease secondary to intracranial aneurysmas or thrombosis of the cavernous sinus. ...

*Necrotizing vasculitis

Seo P, Stone JH (December 2007). "Small-vessel and medium-vessel vasculitis". Arthritis Rheum. 57 (8): 1552-9. doi:10.1002/art. ... 1.5 cm) Isolated cerebral vasculitis. Affects medium and small arteries over a diffuse CNS area, without symptomatic ... Aortitis can also be considered a large-vessel disease. Takayasu arteritis. Primarily affects the aorta and its main branches. ... Arteriograms are helpful in vasculitis affecting the large and medium vessels but not helpful in small vessel vasculitis. ...

*Susac's syndrome

... and brain biopsy findings suggest a small vessel vasculopathy leading to arteriolar occlusion and microinfarction of cerebral, ... Susac's syndrome is a very rare disease, of unknown cause, and many persons who experience it do not display the bizarre ... which revealed sclerosis of the media and adventitia of small pial and cortical vessels, suggestive of a healed angiitis. Both ... Most lesions were small (3 to 7 mm), though some were larger than 7 mm. All 27 patients had corpus callosum lesions. These all ...

*Notch 3

... a model of small vessel diseases of the brain]". J. Soc. Biol. 196 (1): 109-15. PMID 12134625. Guidetti D, Casali B, Mazzei RL ... Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical ... "Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease ... Mutations in NOTCH3 have also been identified in a Turkish family with Alzheimer's disease. Adult Notch3 knock-out mice show ...

*Reversible cerebral vasoconstriction syndrome

... (RCVS, sometimes called Call-Fleming syndrome) is a disease characterized by a ... One small, possibly biased study found that the condition was eventually diagnosed in 45% of outpatients with sudden headache, ... Symptoms are thought to arise from transient abnormalities in the blood vessels of the brain. In some cases, it may be ... The direct cause of the symptoms is believed to be either constriction or dilation of blood vessels in the brain. The ...

*Thrombotic storm

Small vessel thrombosis affecting one or more organs, systems, or tissue; must be documented by histopathology. In addition to ... Cerebral vein thrombosis. Portal vein thrombosis, hepatic vein, or other intra-abdominal thrombotic events. Jugular vein ... Myocardial infarction, in the absence of severe coronary artery disease Stroke and/or transient ischemic attack, in the absence ... Peripheral arterial occlusions, in the absence of underlying atherosclerotic vascular disease, resulting in extremity ischemia ...

*Dementia

... idea that it was due to blockage of the major arteries supplying the brain or small strokes within the vessels of the cerebral ... Tay-Sachs disease, and Wilson's disease (all recessive). Wilson's disease is particularly important since cognition can improve ... The symptoms of this dementia depend on where in the brain the strokes have occurred and whether the vessels are large or small ... People with vascular dementia tend to have risk factors for disease of the blood vessels, such as tobacco use, high blood ...

*Cerebral infarction

In large vessels, the most common causes of thrombi are atherosclerosis and vasoconstriction. In small vessels, the most common ... Caplan LR (September 1989). "Intracranial branch atheromatous disease: a neglected, understudied, and underused concept". ... Atheroma formation can also cause small vessel thrombotic ischemic stroke. An embolic stroke refers to the blockage of an ... Thrombotic ischemia can occur in large or small blood vessels. ... occlusion of a small blood vessel, (4) other determined cause ...

*Brain

Blood vessels enter the central nervous system through holes in the meningeal layers. The cells in the blood vessel walls are ... A prion disease called kuru has been traced to this. The brain can be useful to hunters: most animals have enough brain matter ... The brain is small and simple in some species, such as nematode worms; in other species, including vertebrates, it is the most ... In mammals, the cerebral cortex tends to show large slow delta waves during sleep, faster alpha waves when the animal is awake ...

*Complications of hypertension

... larger vessel or multiple lacunar infarcts due to occlusive small vessel disease resulting in subcortical white matter ischemia ... Cerebral blood flow remains unchanged over a wide range of arterial pressures (mean arterial pressure of 50-150 mmHg) through a ... The other fact about diabetes is that it affects both large and small blood vessels in the body. Over time, blood vessels ... These are also risk factors for renal disease progression and for cardiovascular disease. Diabetes has several complications of ...

*Vascular dementia

Brain vascular lesions can also be the result of diffuse cerebrovascular disease, such as small vessel disease. Risk factors ... Although atheroma of the major cerebral arteries is typical in vascular dementia, smaller vessels and arterioles are mainly ... In small vessel disease, the frontal lobes are often affected. Consequently, patients with vascular dementia tend to perform ... Mixed dementia is diagnosed when people have evidence of Alzheimer's disease and cerebrovascular disease, either clinically or ...

*Charcot-Bouchard aneurysm

... s are aneurysms in the small penetrating blood vessels of the brain. They are associated with ... Charcot-Bouchard aneurysms are a common cause of cerebral hemorrhage. If a Charcot-Bouchard aneurysm ruptures, it will lead to ... by] Vinay Kumar; Abul K. Abbas; Nelson (2005). Robbins and Cotran pathologic basis of disease (7th ed.). Philadelphia: Elsevier ... are aneurysms of the brain vasculature which occur in small blood vessels (less than 300 micrometre diameter). Charcot-Bouchard ...

*Bing-Neel syndrome

This infiltration increases blood viscosity, which impairs blood circulation through small blood vessels of the brain and the ... If any signs of further disease is shown, they will take action to alleviate the symptoms. Because this disease is non-curative ... and/or the cerebral spinal fluid (CSF). Symptoms are diverse and nonspecific, and they can vary depending on which aspect of ... Since the symptoms vary, there are multiple treatment options to treat the symptoms for this non-curable disease. Although ...

*Optic nerve

Similarly, cerebral aneurysms (swelling of blood vessels) can also affect the nerve. Trauma can cause serious injury to the ... Although glaucoma does eventually damage the optic nerve, it is primarily a disease of eye not of the nerve. Optic neuritis is ... Optic nerve hypoplasia is the underdevelopment of the optic nerve resulting in little to no vision in the affected eye. Tumors ... Cerebral peduncle, optic chasm, cerebral aqueduct. Inferior view. Deep dissection. Cranial nerve Vilensky, Joel; Robertson, ...

*Medical ultrasound

... very small transducers can be mounted on small diameter catheters and placed into blood vessels to image the walls and disease ... is frequently used by neuro-anesthesiologists for obtaining information about flow-velocity in the basal cerebral vessels. In ... Higher frequencies have a correspondingly smaller wavelength, and can be used to make sonograms with smaller details. However, ... The smaller the fontanelle, the poorer the quality of the picture. In ophthalmology and optometry, there are two major forms of ...

*Brain ischemia

Focal brain ischemia occurs when a blood clot has occluded a cerebral vessel. Focal brain ischemia reduces blood flow to a ... Recently, Moyamoya disease has also been identified as a potential cause for brain ischemia. Moyamoya disease is an extremely ... Even a small amount of plaque build up can result in the narrowing of passageways, causing that area to become more prone to ... This leads to poor oxygen supply or cerebral hypoxia and thus to the death of brain tissue or cerebral infarction / ischemic ...
Title:Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease. VOLUME: 11 ISSUE: 2. Author(s):Marjolein Huijts, Annelien Duits, Julie Staals, Abraham A Kroon, Peter W de Leeuw and Robert J van Oostenbrugge. Affiliation:Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht , The Netherlands.. Keywords:Cerebral small vessel disease, cognition, enlarged perivascular spaces, hypertension, lacunar stroke, white matter lesions.. Abstract:Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to cSVD severity. A higher number of EPVS were related to decreased cognition in healthy elderly, but this has never been investigated in patients at high risk of cSVD. We included 189 patients with a high risk of cSVD (hypertensive patients and lacunar stroke patients). Patients underwent brain MRI and extensive neuropsychological assessment. EPVS ...
OBJECTIVES: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. METHODS: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p | 0.000084). RESULTS: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, 95%
© Cambridge University Press 2014. Introduction: Cerebral ischemia is thought to be an important disease mechanism in cerebral small vessel disease (SVD). It has been hypothesized that acute ischemia in the territory of the perforating artery results in lacunar stroke, while chronic ischemia occurring in the distal territories of the perforating arteries results in changes to cerebral white-matter, known as leukoaraiosis. The spatial pattern of leukoaraiosis, with changes first occurring in the brain regions furthest from the origin of the perforating arteries, would be consistent with disease occurring due to hypoperfusion. This has led to the suggestion that cerebral blood flow (CBF) is reduced in SVD, and many studies have been performed to investigate this issue. In addition, cerebral arteriopathy underlying SVD may also impair the ability of small cerebral vessels to vasodilate, leading to problems maintaining perfusion in response to drops in blood pressure and perfusion pressure. Impairments of
Obkective: Fibrinogen levels and fibrinogen clot structure have been implicated in pathogenesis of vascular disease. We examined fibrinogen levels and variation in fibrinogen genes (fibrinogen γ (FGG), α (FGA) and β (FGB)), associated with fibrin clot structure and fibrinogen levels, in relation to cerebral small vessel disease (SVD). Methods and Results This study was performed in the Rotterdam Scan Study, a population-based study among 1077 elderly with cerebral magnetic resonance imaging. Plasma fibrinogen levels and haplotypes were determined. We examined the association of fibrinogen levels and haplotypes with silent brain infarcts and white matter lesions by means of logistic regression models. We constructed seven haplotypes (frequency ,0.01) that describe the total common variation in the FGG and FGA genes. Haplotype 2 (G-A-T-A-G-T-G) was associated with presence of silent brain infarcts when compared to the most frequent haplotype (G-G-T-G-G-T-A) (odds ratio (OR) 1.41, 95% CI ...
Braun H, Schreiber S. Microbleeds in cerebral small vessel disease. Lancet Neurol. 2013 Aug;12(8):735-6.. Mencl S, Garz C, Niklass S, Braun H, Göb E, Homola G, Heinze HJ, Reymann KG, Kleinschnitz C, Schreiber S. Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats. Exp Transl Stroke Med. 2013 Jun 25;5:8.. Bueche CZ, Garz C, Kropf S, Bittner D, Li W, Goertler M, Heinze HJ, Reymann K, Braun H, Schreiber S. NAC changes the course of cerebral small vessel disease in SHRSP and reveals new insights for the meaning of stases - a randomized controlled study. Exp Transl Stroke Med. 2013 Apr 15;5:5. Schreiber S, Bueche CZ, Garz C, Braun H. Blood brain barrier breakdown as the starting point of cerebral small vessel disease? - New insights from a rat model. Exp Transl Stroke Med. 2013 Mar 14;5(1):4. Braun H, Bueche CZ, Garz C, Oldag A, Heinze HJ, Goertler M, Reymann ...
TY - JOUR. T1 - Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. AU - METASTROKE Consortium. AU - CHARGE WMH Group. AU - ISGC ICH GWAS Study Collaboration. AU - WMH in Ischemic Stroke GWAS Study Collaboration. AU - International Stroke Genetics Consortium. AU - Rannikmäe, Kristiina. AU - Davies, Gail. AU - Thomson, Pippa A.. AU - Bevan, Steve. AU - Devan, William J.. AU - Falcone, Guido J.. AU - Traylor, Matthew. AU - Anderson, Christopher D.. AU - Battey, Thomas W.K.. AU - Radmanesh, Farid. AU - Deka, Ranjan. AU - Woo, Jessica G.. AU - Martin, Lisa J.. AU - Jimenez-Conde, Jordi. AU - Selim, Magdy. AU - Brown, Devin L.. AU - Silliman, Scott L.. AU - Kidwell, Chelsea S.. AU - Montaner, Joan. AU - Langefeld, Carl D.. AU - Slowik, Agnieszka. AU - Hansen, Björn M.. AU - Lindgren, Arne G.. AU - Meschia, James F.. AU - Fornage, Myriam. AU - Bis, Joshua C.. AU - Debette, Stéphanie. AU - Ikram, Mohammad A.. AU - Longstreth, Will T.. AU - Schmidt, ...
Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in its advanced stages once its symptomatic sequelae develop. However, its significance in asymptomatic healthy populations remains poorly defined. In population-based studies of presumed healthy elderly individuals, CSVD neuroimaging markers including white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, cortical superficial siderosis, and cerebral microinfarcts are frequently detected. While the presence of these imaging markers may reflect unique mechanisms at play, there are likely shared pathways underlying CSVD. Herein, we aim to assess the etiology and significance of these individual biomarkers by focusing in asymptomatic populations at an epidemiological level. By primarily examining population-based studies, we explore the risk factors that are involved in the ...
Fondation Leducq have funded an international network to investigate the role of the perivascular space in cerebral small vessel disease. There is a huge unmet need to understand the pathophysiology of small vessel disease. Our network, which links clinical and preclinical research across North America and Europe, aims to address this. ...
Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We developed the Brief Memory and Executive Test (BMET); a rapid screening measure sensitive to the impaired executive function and processing speed characteristic of small vessel disease (SVD). To assess the BMETs validity for general use, we evaluated it when administered by non-psychologists in a multicentre study and collected control data to derive normative scores. Two-hundred participants with SVD, defined as a clinical lacunar stroke and a corresponding lacunar infarct on MRI, and 303 healthy controls aged between 40-90 years old were recruited. The BMET, as well as the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE), were performed. Overall, 55 SVD participants underwent repeat testing at 3 months to assess the BMET test-retest reliability. Administering the BMET
1. Moran C, Phan TG, Srikanth VK. Cerebral small vessel disease: A review of clinical, radiological, and histopathological phenotypes. International Journal of Stroke. 2012;7:36-46 2. Pantoni L. Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9:689-701 3. Xiong YY, Mok V. Age-related white matter changes. Journal of Aging Research. 2011;2011:1-13 4. Xiong Y, Mok V, Wong A, Chen X, Chu WC, Fan Y, Soo Y, Wong KS. The age-related white matter changes scale correlates with cognitive impairment. Eur J Neurol. 2010;17:1451-1456 5. Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis. Bmj. 2010;341:c3666 6. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and subjective cognitive dysfunction: The rotterdam scan study. Neurology. 2001;56:1539-1545 7. Chowdhury MH, Nagai A, Bokura ...
Here, we demonstrated that endothelial dysfunction is an early precipitant of disease development in a rat model of SVD and a sample of humans with sporadic SVD. We identified a deletion in Atp11b and loss of ATP11B protein that cause endothelial dysfunction, with abnormalities of the BBB TJs, increased EC proliferation, and reduction in eNOS and NO. This dysfunction led to secretion of factors, including HSP90α, which blocked the maturation of OPCs into myelinating oligodendrocytes, consistent with the impairment of myelination and inherent vulnerability of white matter to damage seen in adult humans with SVD (42). We also demonstrated therapeutic reversal of endothelial dysfunction and associated reduction in white matter vulnerability. The early reduction of the BBB TJ markers but lack of tracer leakage (along with the brain slice culture experiments) showed that leakage of substances through the BBB is not important for initial SVD pathology in our model. However, it is highly likely that ...
Scans of sufficient quality for data analysis were available in 29 cases and 35 controls. NAA was significantly reduced in patients compared with controls (lower by 7.27%, P = 0.004). However, when lesion load within each individual voxel (mean 22% in SVD vs 5% in controls, P , 0.001) was added as a covariate, these differences were no longer significant, suggesting that the metabolite differences arose primarily from differences in lesioned tissue. In patients with SVD, there was no correlation between cognitive scores and any brain metabolite. No lactate, an indicator of anaerobic metabolism, was detected. ...
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Cerebrovascular trauma, also known as blunt cerebrovascular injury (BCVI) is a non-penetrating injury to the carotid and/or vertebral artery that may cause stroke in trauma patients. Discover the latest research on cerebrovascular trauma here. ...
Stroke and dementia are common and debilitating health issues worldwide. Cerebral small vessel disease (SVD) underlies a large proportion of these cases. However, the cause of SVD is unknown. Research into the causes and pathophysiological mechanisms of SVD is hampered by the fact that small vessels themselves are difficult to visualise in people. The wide range of clinical
The connection between COPD and cerebral small vessel disease was suggested by two earlier studies, but the connection between COPD and cerebral microbleeds, the location of which can help elucidate underlying disease mechanisms, has not been studied," said researchers Lies Lahousse, PhD, of the Department of Respiratory Medicine at Ghent University Hospital in Belgium and Bruno Stricker, PhD, of the Department of Epidemiology at Erasmus Medical Center in Rotterdam, the Netherlands. "In the current study, we found, for the first time, that COPD increases the risk of cerebral microbleeds in deep or infratentorial brain regions, not only in a cross-sectional analysis but also in a longitudinal analysis in subjects without microbleeds at baseline.". Microbleeds in deep (deep gray matter of the basal ganglia and thalamus and white matter of the corpus callosum, internal, external, and extreme capsule) or infratentorial (brainstem and cerebellum) locations are suggestive of hypertensive or ...
Pulmonary hypertension is a significant cause of morbidity and mortality. Unfortunately, non-specific presentation and lack of awareness of the disease frequently lead to significant delay in diagnosis, often with the onset of right heart failure, when prognosis is poor and therapy is of limited effectiveness. The classification of pulmonary hypertension is a clinical one grouping diseases into categories with similar patho-physiological mechanism and therapeutic options. Pulmonary biopsy can provide a definitive diagnosis but is hazardous in patients with pulmonary hypertension. Imaging has emerged as an invaluable tool in differentiating the aetiology, assessing disease severity and directing further management. One of the most important roles of imaging is to differentiate diseases resulting from obstruction of the large pulmonary arteries from those secondary to diffuse small vessel disease, as these have very different prognosis and are also treated differently. Small vessel diseases ...
Focal white-matter lesions in the brain have been frequently found in patients with inflammatory bowel disease. These findings have been discussed as a novel extraintestinal manifestation of...
Common cerebral small vessel disease (cSVD) abnormalities are a common neuroradiological finding, especially in the elderly. They are associated with a wide cli
As a clinical academic I divide my time equally between clinical stroke care (at University College Hospital and The National Hospital for Neurology and Neurosurgery, Queen Square) and academic commitments at the Stroke Research Centre, UCL Institute of Neurology. My major research interest is in the clinical an pathophysiological implications of cerebral small vessel disease (the commonest known brain disorder). My focus is on intracranial (including intracerebral) haemorrhage, which is the most devastating type of stroke. I have expertise in observational studies and neuroimaging including magnetic resonance imaging (MRI). I lead a research programme including observational, genetic and neuroimaging studies of subarachnoid haemorrhage and intracerebral haemorrhage, with particular expertise in cerebral amyloid angiopathy. I am Chief Investigator for the Clinical Relevance of Microbleeds in Stroke (CROMIS-2) study: www.ucl.ac.uk/cromis-2. In collaboration with Prof Peter Rothwell (Oxford) I am ...
Hi have any of you been told you have Small Vessel Disease or MS after an MRI my latest MRI shows I may have SVD or MS I dont think it is MS to be honest, but lately my dizziness and memory and...
Cardiac magnetic resonance imaging (CMR) with adenosine-stress myocardial perfusion is gaining importance for the detection and quantification of coronary artery disease (CAD). However, there is little knowledge about patients with CMR-detected ischemia, but having no relevant stenosis as seen on coronary angiography (CA). The aims of our study were to characterize these patients by CMR and CA and evaluate correlations and potential reasons for the ischemic findings. 73 patients with an indication for CA were first scanned on a 1.5T whole-body CMR-scanner including adenosine-stress first-pass perfusion. The images were analyzed by two independent investigators for myocardial perfusion which was classified as subendocardial ischemia (n = 22), no perfusion deficit (n = 27, control 1), or more than subendocardial ischemia (n = 24, control 2). All patients underwent CA, and a highly significant correlation between the classification of CMR perfusion deficit and the degree of coronary luminal ...
small vessels - MedHelps small vessels Center for Information, Symptoms, Resources, Treatments and Tools for small vessels. Find small vessels information, treatments for small vessels and small vessels symptoms.
Question - Suggest treatment for Triple Vessel Disease . Ask a Doctor about diagnosis, treatment and medication for Triple vessel disease, Ask a Cardiologist
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We know that sleep apnea can seriously affect the heart (right-sided failure) and brain (increased risk of small vessel disease and mini strokes). But why the eyes? Some investigators feel the cause is mechanical stress--i.e. smashing and stretching the eye against pillow--which is supported by the fact that one-sided sleepers often get one-sided F.E.S. Others wonder if alternating ischemia (not enough oxygenated blood) followed by reperfusion (flood of oxygen-rich blood when the apnea ceases) results in tissue inflammation. Studies of floppy lids (what happened to the sleeper upon which these lids resided!?!) showed an inflammatory injury reaction consistent with both stress and ischemia as seen in other tissue types ...
Tough problem. I cant make recommendations, but diffuse small vessel disease can be tough to manage. Stents and bypasses to the heart need a minimum diameter and only work with discrete blockages not a narrowing of an entire vessel. Treatment often involves anti-platelets (aspirin etc) aggressive diabetes control, cholesterol control, diet, weight loss. Talk with your doctor maybe second opinion if not happy ...
Euphemia was diagnosed with triple vessel disease and treated through cardiac rehab at the UPMC Heart and Vascular Institute. Read more.
Dose Management. We understand that delivering quality diagnostic care with the lowest possible radiation dose is a desired goal. Learn how our Dose Management solutions can help you achieve Dose Leadership. Dose Management Överblick ...
SVD models(A) SVD exploratory model of the relationships among physical disability, depression, and reduction in QoL, in SVD. (B) SVD replication analysis of mo
Un sitio de patolog a renal para disfrutar los hallazgos microsc picos de las enfermedades renales que afectan al hombre. P ginas relevantes en nefropatolog a, neoplasias renales, trasplante renal y mucho m s. Welcome to the magic world of nephropathology, glomeruli, podocites, interstituim and so on in kidney pathology. Kidney disease, atlas and text.
TY - JOUR. T1 - Microvascular pathology and morphometrics of sporadic and hereditary small vessel diseases of the brain. AU - Craggs, Lucinda J L. AU - Yamamoto, Yumi. AU - Deramecourt, Vincent. AU - Kalaria, Raj N.. N1 - No record of this in Eprints. HN 29/11/2017. PY - 2014/9. Y1 - 2014/9. N2 - Small vessel diseases (SVDs) of the brain are likely to become increasingly common in tandem with the rise in the aging population. In recent years, neuroimaging and pathological studies have informed on the pathogenesis of sporadic SVD and several single gene (monogenic) disorders predisposing to subcortical strokes and diffuse white matter disease. However, one of the limitations toward studying SVD lies in the lack of consistent assessment criteria and lesion burden for both clinical and pathological measures. Arteriolosclerosis and diffuse white matter changes are the hallmark features of both sporadic and hereditary SVDs. The pathogenesis of the arteriopathy is the key to understanding the ...
Stroke is an important risk factor for dementia. Epidemiological studies have indicated a high incidence of dementia in stroke patients. There is currently no effective biomarker for the diagnosis of post-stroke dementia (PSD). D-amino acid oxidase (DAO) is a flavin-dependent enzyme widely distributed in the central nervous system. DAO oxidizes D-amino acids, a process which generates neurotoxic hydrogen peroxide and leads to neurodegeneration. This study aimed to examine post-stroke plasma DAO levels as a biomarker for PSD. In total, 53 patients with PSD, 20 post-stroke patients without dementia (PSNoD), and 71 age- and gender-matched normal controls were recruited. Cognitive function was evaluated at more than 30 days post-stroke. Plasma DAO was measured using the enzyme-linked immunosorbent assay. White matter hyperintensity (WMH), a neuroimaging biomarker of cerebral small vessel diseases, was determined by magnetic resonance imaging. We found that plasma DAO levels were independently higher in PSD
Results: A total of 212 patients, mean age (±SD) 69.5 years (±16.1), 102 (48%) male, had available MR before IV thrombolysis. Evidence of BBB leakage was present in 175 (80%) and 205 (94%) patients in the ischemic and nonischemic area, respectively. Lacunar infarcts (β = 0.17, p = 0.042) were associated with BBB leakage in the ischemic area, and brain atrophy was associated with BBB leakage in both ischemic (β = 0.20, p = 0.026) and nonischemic (β = 0.27, p = 0.001) areas. Increasing SVD grade was independently associated with BBB leakage in both ischemic (β = 0.26, p = 0.007) and nonischemic (β = 0.27, p = 0.003) area. ...
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DEAR DR. DONOHUE: I am a 71-year-old woman. I take medicine for high blood pressure and for cholesterol control. For a long time Ive been havi
Attempts to treat extensive ulcerations of legs due to small vessel disease. 58 year- old woman with multiple failed graft attempts to treat extensive ulcerations of legs due to small vessel disease. The patient had a very poor response to aggressive medical and surgical approaches. The clinical improvement with 20 hyperbaric oxygen sessions @ 2.0 ATA for 90 minutes each, was dramatic. She had decreased swelling (edema), no pain or bleeding and was able to wear shoes and resume activities of daily living such as shopping. After 40 sessions the wounds were completely healed and the overall functional skills of the patient improved significantly.. ...
INTRODUCTION: White matter hyperintensities (WMHs) are areas of abnormal signal on magnetic resonance images (MRIs) that characterize various types of histopathological lesions. The load and location of WMHs are important clinical measures that may indicate the presence of small vessel disease in aging and Alzheimers disease (AD) patients. Manually segmenting WMHs is time consuming and prone to inter-rater and intra-rater variabilities. Automated tools that can accurately and robustly detect these lesions can be used to measure the vascular burden in individuals with AD or the elderly population in general. Many WMH segmentation techniques use a classifier in combination with a set of intensity and location features to segment WMHs, however, the optimal choice of classifier is unknown. METHODS: We compare 10 different linear and nonlinear classification techniques to identify WMHs from MRI data. Each classifier is trained and optimized based on a set of features obtained from co-registered MR ...
The term cognition describes the human brains ability to learn, think, and process information. For a normal daily life to be possible, cognitive functions must be intact. Impairment of cognitive functions results in difficulties in coping with both complex and everyday activities, such as daily planning, meeting the demands of work life, managing finances, preparing food, keeping order, socializing, or cultivating interests. Impaired cognitive functions also lead to an increased sensitivity to stress.. There are several disorders and medical procedures that show cognitive impairment as an important - though not always identified - manifestation, such as affective disorders, schizophrenia, abuse, neurological motor disorders, MS, traumatic brain injury, cancer, infections, vascular disease (ischemic heart disorder, heart failure, hypertension, diabetes mellitus, stroke, small vessel disease), coronary by-pass surgery, and other major surgical procedures. Multimorbidity relatively often result ...
The "Special Course" which typically launches the annual AANP meeting was anything but typical this year. Rather than the usual series of research presentations which has characterized the first day of the meeting, the 2015 edition of the "Special Course" focused on need-to-know practical topics. Dr. Beatriz Lopes put together a program that offered something for everyone -- from trainee to seasoned practitioner. The morning started with a presentation by Dr. Caterina Giannini on primary CNS lymphoma, as well as its mimickers and precursors. Far from being a straightforward diagnosis, lymphoma -- particularly in the setting of corticosteroid therapy -- can be mistaken for anything from multiple sclerosis to infarct. Next, two eminent scholars from Paris, Drs. Francoise Gray and Elisabeth Tournier-Lasserve, presented a three-part lecture on the hereditary non-amyloid small vessel diseases of the brain. Then Charles Eberhart showed up from Johns Hopkins to provide a primer on ophthalmic pathology, ...
Bob,. Tks for sharing that article with us. Alot of people are still using these medicines in their daily treatment plan with good results, but there are some that hopefully their doctors are weighing the odds of this treatment.. I wonder, if in this study that was conducted, if these patients were checked for undetected underlying causes that could have caused the their negative reactions like, heart disease, lung conditions and in my case, small vessel disease that wasnt detected in me until I had a minor stroke.. Of course we all know that all medicines have risks and the drug companies have to list every possible reaction or interaction. This can be scarey to anyone that reads all this information, but in most cases the serious reactions are rare.. Hopefully patients are being more proactive in their care and questioning all aspects of treatment with their doctors before starting anything new.. Tks again, Babs. ...
I am supervisor for a research group, which right now consists of one PhD student, and three master students. My research is focused on understanding the molecular mechanism behind Alzheimer Disease with focused on Omi/HtrA2 protease and amyloid beta uptake, and focus on vascular smooth muscle cell degeneration and proliferation in CADASIL as well as small vessel diseases.. In addition to supervising, I am as a researcher involved in teaching at both the masters, advanced and doctoral level. Furthermore, I am organizer for "PhD/PostDoc" and "Center for Alzheimer Research" seminar series at NVS. This role gives me a lot of input and reflections to my own leadership style and also I learn to know PhD students at KI, which is a benefit for my research career.. I am representative for "Equal treatment" (Ombud for Lika Villkor) at NVS since 2011. Therefore, I am a member of department council and work environment council at NVS. This role also gives me the opportunity to be involved in many issues ...
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In a bid to improve awareness and care of a relatively rare disorder that inflames blood vessels throughout the body and damages organs, especially the eyes, a team of researchers led by a Johns Hopkins ophthalmologist has analyzed and published detailed information about 132 patients diagnosed and treated over 25 years in Saudi Arabia, where the disorder is not at all rare.
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease and are highly heritable. To date, large-scale genetic studies have identified only a single locus influencing WMH burden. This might in part relate to biological heterogeneity of sporadic WMH. The current study searched for genetic modifiers of WMH volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease.. METHODS: We performed a genome-wide association study to identify quantitative trait loci for WMH volume by combining data from 517 CADASIL patients collected through 7 centers across Europe. WMH volumes were centrally analyzed and quantified on fluid attenuated inversion recovery images. Genotyping was performed using the Affymetrix 6.0 platform. Individuals were assigned to 2 distinct genetic clusters (cluster 1 and cluster 2) based on their genetic background.. RESULTS: ...
The protective effect of education has been well established in Alzheimers disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear. We examined the correlation of education with cortical thickness and cerebral small vessel disease markers in patients with pure subcortical vascular mild cognitive impairment (svMCI) and patients with pure subcortical vascular dementia (SVaD). We analyzed 45 patients with svMCI and 47 patients with SVaD with negative results on Pittsburgh compound B positron emission tomographic imaging who underwent structural brain magnetic resonance imaging. The main outcome was cortical thickness measured using surface-based morphometric analysis. We also assessed the volumes of white matter hyperintensities (WMH) and numbers of lacunes as other outcomes. To investigate the correlation of education with cortical thickness, WMH volume, and number of lacunes, multiple linear regression analyses were performed after controlling for covariates,
Cerebral microbleeds (CMB) are focal haemosiderin deposits that result from minimal blood leakage from damaged small vessels, and they can be regarded as markers of pathological vascular changes. In addition to their association with small vessel disease, CMB have also been pathologically linked to cerebral amyloid angiopathy.1 The prevalence of CMB in the general population increases from 20% in subjects aged 60-69 years to 40% in subjects aged 80 years and older.2 Clinically, CMB have been associated with cerebrovascular disease and some of its risk factors, including lacunar infarcts, intracerebral haemorrhage, white matter changes and hypertension. CMB have also been reported to be increased in Binswanger disease, mild cognitive impairment and Alzheimers disease (AD).1 ,2 The location and distribution of CMB … ...
Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies.For the discovery sample, we did a genome-wide analysis of common genetic variants associated with incident stroke risk in 18 population-based cohorts comprising 84 961 participants, of whom 4348 had stroke. Stroke diagnosis was ascertained and validated by the study investigators. Mean age at stroke ranged from 45·8 years to 76·4 years, and data collection in the studies took place between 1948 and 2013. We did validation analyses for variants yielding a significant association (at p|5 × 10(-6)) with all-stroke, ischaemic stroke, cardioembolic ischaemic stroke, or non-cardioembolic ischaemic stroke in the largest available cross-sectional studies (70 804 participants, of whom 19 816 had stroke). Summary-level results of
The purpose of this research is to understand how to apply cardiac magnetic resonance imaging (CMR) to women with small artery heart disease by looking at the CMRs of women without heart disease. The investigators will study 40 women with no heart disease to learn more about the usefulness of CMR.. Women suffer more than men from this disorder of the small vessels compared to the large vessels. This results in delays in diagnosis, missed opportunities for treatment, and likely contributes to the increased death rate from heart disease in women compared to men. Current testing for small vessel disease is invasive and not performed routinely and women are often not initiated on appropriate lifesaving treatment. New imaging and noninvasive technology exists that may improve this situation. Imaging techniques such as cardiac magnetic resonance imaging (CMR) can now show the inner layers of the heart where the small vessel abnormality and myocardial ischemia exist. These techniques, while promising, ...
Diabetes is an increasing risk factor for vascular cognitive impairment (VCI), which is defined as cognitive deficits associated with small vessel disease (SVD) and/or lacunar infarction due to the occlusion of terminal arterioles by emboli in the brain. Microemboli even in sizes that would not cause complete occlusion are quite common in the cerebral circulation and are more so in patients with diabetes that present with a hypercoagulable state. Lack of understanding of the role and mechanisms by which microemboli can contribute to increased disease burden in diabetes is a critical gap in our knowledge. The objectives of this DiaComp Pilot & Feasibility Program grant application are to begin addressing this important clinical problem by establishing a novel animal model and gathering proof-of-concept data to implicate the vascular dysfunction and microemboli interaction in the development of cerebral SVD preceding the VCI in diabetes. We propose that the microemboli injected through the ...
Cerebral microbleeds (CMBs) are defined as small, rounded, or ovoid, homogeneous hypointense lesions on T2*-weighted gradient-echo and other susceptibility-sensitive magnetic resonance imaging (MRI) s
The Journal of Stroke (JoS) provides stroke clinicians and researchers with peer-reviewed articles on clinical and basic investigation of cerebral circulation and associated diseases to enhance patient management, education, clinical or experimental research, and professionalism. The jour-nal will consider submissions in areas including, but not limited to, the following: pathophysiology, risk factors, symptomatology, imaging, treat¬ment, and rehabilitation of stroke. We have a particular interest in strokes in Asian populations as they have features distinct from strokes in the other part of the world. Clinical researches on intracranial atherosclerosis, small vessel diseases, hemorrhagic strokes, and relevant basic research¬es are welcome, as are issues in epidemiology, public education, and clinical practice guidelines in Asian countries.
The Journal of Stroke (JoS) provides stroke clinicians and researchers with peer-reviewed articles on clinical and basic investigation of cerebral circulation and associated diseases to enhance patient management, education, clinical or experimental research, and professionalism. The jour-nal will consider submissions in areas including, but not limited to, the following: pathophysiology, risk factors, symptomatology, imaging, treat¬ment, and rehabilitation of stroke. We have a particular interest in strokes in Asian populations as they have features distinct from strokes in the other part of the world. Clinical researches on intracranial atherosclerosis, small vessel diseases, hemorrhagic strokes, and relevant basic research¬es are welcome, as are issues in epidemiology, public education, and clinical practice guidelines in Asian countries.
The Psychiatry Investigation (Psychiatry Investig) provides stroke clinicians and researchers with peer-reviewed articles on clinical and basic investigation of cerebral circulation and associated diseases to enhance patient management, education, clinical or experimental research, and professionalism. The jour-nal will consider submissions in areas including, but not limited to, the following: pathophysiology, risk factors, symptomatology, imaging, treat¬ment, and rehabilitation of stroke. We have a particular interest in strokes in Asian populations as they have features distinct from strokes in the other part of the world. Clinical researches on intracranial atherosclerosis, small vessel diseases, hemorrhagic strokes, and relevant basic research¬es are welcome, as are issues in epidemiology, public education, and clinical practice guidelines in Asian countries.
The Psychiatry Investigation (Psychiatry Investig) provides stroke clinicians and researchers with peer-reviewed articles on clinical and basic investigation of cerebral circulation and associated diseases to enhance patient management, education, clinical or experimental research, and professionalism. The jour-nal will consider submissions in areas including, but not limited to, the following: pathophysiology, risk factors, symptomatology, imaging, treat¬ment, and rehabilitation of stroke. We have a particular interest in strokes in Asian populations as they have features distinct from strokes in the other part of the world. Clinical researches on intracranial atherosclerosis, small vessel diseases, hemorrhagic strokes, and relevant basic research¬es are welcome, as are issues in epidemiology, public education, and clinical practice guidelines in Asian countries.
SHG Preise. Die SHG hat anlässlich Ihrer Jahrestagung in St. Gallen am 9.1.2020 folgende Preise vergeben:. · SHG-Förderpreis an Frau Dr. Martina Göldlin, Stroke Center Inselspital Bern, für das Projekt "MRI small vessel disease phenotype: a new approach to classify intracerebral haemorrhage subtypes". · SHG-Preis für die beste mündliche Präsentation an Dr. Johannes Käsmacher, Stroke Center Inselspital Bern, für die Studie «Safety and efficacy of intra-arterial Urokinase after failed, unsuccessful or incomplete mechanical thrombectomy in anterior circulation large-vessel occlusion stroke: A prospective cohort study". ...
Irvine, Calif.- A small amount of bleeding in the brain seems to be common among older individuals, according to a UC Irvine study. Neurologist Dr. Mark Fisher and neuropathologist Dr. Ronald Kim found that cerebral microbleeds are highly prevalent in the aging brain - and not primarily products of stroke-related injury, hypertension or neurodegenerative diseases such as Alzheimers, as had been thought. "Prior work relied on brain imaging to show cerebral microbleeds," Fisher said. "But in this study, deep regions of the brain were closely examined under a microscope, and nearly all subjects had evidence of small areas of bleeding." Results appear online in the journal Stroke . Fisher, Kim and colleagues at Harbor-UCLA Medical Center studied postmortem brain specimens from 33 individuals, ranging in age from 71 to 105, with no history of stroke. Cerebral microbleeds were identified in 22 cases - all occurring in capillaries, the small blood vessels of the brain. This is a substantially higher ...
Victims of physical violence were one and a half times more likely to suffer from narrowing of the main blood vessels in the neck that carry blood to the brain
However much we might like to, we cannot change our age or its effect on our risk of heart and blood vessel disease. However, you can change many other characteristics and conditions that put you at risk for PAD. The older you get, the more important it becomes to get your other PAD risk factors under control. Older women with PAD are at especially high risk for potentially deadly complications of artery disease such as heart attack and stroke.. The first step in taking control of your PAD risk is to work with your doctor to find out what your risk factors are and develop a treatment plan to get your numbers where they need to be. Lifestyle changes such as a heart-healthy diet and exercise are a major part of risk factor control. Talk to your doctor about what level of activity is safe for you and aim for at least 30 minutes of exercise each day. It is never too late to start making heart-healthy changes to reduce your risk, and many of these changes can also help prevent heart disease and ...
BriefTTY Biopharm Company Ltd is a biopharmaceutical company that research, develops and markets drugs for cancer, anti-infection and blood vessel diseases. The ...
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Sinusoids are small vessels found in certain organs. Sinusoids have large pores that allow blood cells and molecules to pass through their thin walls.
Microangiopathies may cause ischemic brain lesions and are of fundamental importance in vascular dementia. Risk factors include high age, hypertension, diabetes and Alzheimers disease. In addition, recent studies have focused on autosomal dominant types of arteriopathy causing leukoencephalopathy,psychiatric disturbances, stroke and dementia (CADASIL). This thesis concerns various collagens andbasal lamina components which are deposited in vascular walls of cases presenting cerebral microangiopathy. In addition, endothelin-like immunoreactivity has been studied in CADASIL cases andsome other brain diseases.. CADASIL cases described by Sourander and Wålinder (1977) were re-investigated. Those with longduration of the disease presented marked expression of fibrillary collagen types I, Ill, V and VI and of thebasal lamina components, collagen type IV and laminin. Deposits appeared also in non-familial casespresenting hyalinosis and in cases with the Binswanger type of leukoencephalopathy. Media ...
USC research sheds new light on how a breakdown in the brains vascular system predates the accumulation of toxic plaques and tangles in the brain that bring about Alzheimers disease. The research suggests an earlier target for preventing dementia and Alzheimers. Nearly 50 percent of all dementias, including Alzheimers, begins with the breakdown of the smallest blood vessels in the brain and their protective gatekeeper cells, according to a Keck School of Medicine of USC study. That catastrophe causes a communications failure called small vessel disease. Many people with that disease also have white matter disease, the wearing away of fatty myelin that allows neurons to transfer messages within the brain network. In an animal model, researchers found that brain deterioration associated with dementia may start as early 40 in humans. For more than 25 years, scientists have known that white matter disease impedes a persons ability to learn or remember new things, slows thinking and causes people to
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In this study, we found a fair-to-moderate inter- and intraobserver reliability for the presence of microbleeds by using 3D T2*-weighted imaging at 1.5T and moderate-to-good reliability by using dual-echo T2*-weighted imaging at 7T. For the number of microbleeds, the reliability was better; it was moderate at 1.5T and good to very good at 7T. Overall, we found an increased reliability for both presence and number of microbleeds at 7T compared with 1.5T. Cerebral microbleeds were detected in more patients at 7T than at 1.5T. Furthermore, the number of microbleeds detected was higher at 7T.. Besides the detection of microbleeds in more patients and a higher number of microbleeds at 7T, the reliability of the detection also improves. Compared with 1.5T, both inter- and intraobserver reliability improved at 7T. This might be due to the higher resolution, increased SNR, and the use of the dual- echo sequence at 7T. Recently, we showed that the TE1 image provides a good contrast of the dark ...
Leaky blood vessels in the brain called cerebral microbleeds are associated with an increased risk of physical and cognitive disability in patients with multiple sclerosis (MS). Cerebral microbleeds become more common with age and are a known risk factor for dementia.
CMBS bond spreads (and hence spreads to borrowers on their loans) and the Swap rate (the index used to set CMBS conduit loan rates) both fell as 2012 progressed; by year-end, the combination resulted in the lowest CMBS conduit loan rates ever recorded. In January 2012, Goldman Sachs priced the only multi-borrower CMBS deal for…
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Novel strategies to prevent and treat stroke that are both safe and effective are desperately needed in order to alleviate the burden of post-stroke disability....
Researchers say that high levels of the amino acid homocysteine may increase the risk of brain atrophy and blood vessel disease, researchers report.
In terms of dosages, for men the optimal dose is 40-100mgs per day, and for women it's around 5-15mgs per day. People with heart ailments and those whove had heart attacks should consult their physicians before buying the product. Why Winstrol Helps, steroids as a class are basically hormones that you can consume that signal your body that it should build more muscle. By using these substances, you can build muscles that are larger, more powerful, and have better endurance than you could possibly get with the same amount of time and work on your own. How to buy, winstrol online from steroid sites. This supplement is FDA approved which simply means that it is very safe and legal so there is nothing to worry. Its a lot easier to just pop a pill on schedule. So it is advisable to do a thorough study of these products and then try the one thats best suited. Does a, winstrol only. People with high cholesterol or blood vessel diseases, blood clots and bleeding problems, and those having diabetic, ...
All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years ...
hemispheres. These are nonspecific in appearance, but may be related to the patients migraine headaches. Small vessel disease or a demyelinating process; however, cannot be excluded. He later included an addendum when the previous exam was available for comparison: Examination 3/27/2008 is now available for comparison. The tiny foci of abnormal T2/FLAIR signal are more apparent on todays study. However, the majority of these were present on the previous study. There appears to be one new focus on todays exam that was not present on the previous study. I realize that things could be much worse, but until someone can help me understand what these foci are and what they mean....etc...I am kinda worried ...
Rather than having trouble with the heart contracting so it can pump blood out to the body, older, obese individuals in heart failure tend to have issues with the heart muscle being able to relax and fill efficiently, called diastolic heart failure, Bagi says. Relaxation actually requires more energy than contracting, and the scientist hopes his studies will help this patient population, for which currently there are no good, targeted treatment options. He has begun looking at antibodies that would directly target and ideally reduce levels of ADAM17 in the face of aged fat and at least delay development of small vessel disease ...
The Aliens technical ability to perform various types of surgery on the human body without visible incisions is particularly evident in their effective treatment of blood vessels.. Case 1: A young woman doctor came to me for a demonstration treatment. Her presenting complaint was pains in her legs after hours of being on her feet in the Intensive Care Unit where she works. The Aliens suggested demonstrating the procedure of blood vessel cleaning. She lied down on the treatment bed and closed her eyes to avoid any psychological influence of auto-suggestion by watching my hand movements. After just a few minutes she reported sensations in her legs, like internal scratching. Something was moving inside her veins.. Case 2: A woman in her fifties was also treated for pains in the legs resulting from prolonged standing. After a few treatments she reported that the pains had disappeared.. Case 3: A man of 65 suffered from a narrowing of the blood vessels in his legs. He had chronic pain in his legs and ...
Free flashcards to help memorize facts about USCSOM: Pathology: blood vessel disease terms. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
With a little effort on each of our parts and a willingness to change, we can make a big difference in the incidence of this nations number one killer, cardiovascular disease (CVD). Heart and blood vessel disease are not inevitable; in fact, they are preventable in most cases.
Our board-certified doctors include world-renowned experts in every area of cardiology. Our doctors find, treat and prevent heart and blood vessel diseases.
Children and teens who experience abuse, bullying, neglect or witness violence and other forms of adversity are more likely to develop heart and blood vessel diseases as adults. Unhealthy responses to stress (such as overeating), mental health problems and disruptions in basic biologic processes may underlie the increased risk.
Dr. Rick Swartz completed his MD and PhD training and neurology residency at the University of Toronto. His appointments and affiliations include Stroke Neurologist, Sunnybrook Health Science Centre; Assistant Professor, Division of Neurology, Department of Medicine, University of Toronto; directing the Sunnybrook Stroke Research Unit; Medical Director, NE-GTA Regional Stroke Network; and Director, University of Toronto Stroke Program. As a clinician-scientist, his clinical specialty is stroke neurology, with a focus on stroke in the young, stroke in pregnancy, intracranial vascular diseases, and the functional consequences of stroke including vascular cognitive impairment. His research focuses on improving functional impairment in stroke - from hyperacute clinical trials to long-term complications, with a focus on intracranial vascular diseases including both small vessel disease and the cognitive impact of stroke and neuroimaging biomarkers of intracranial arterial disease.. He developed and ...
99 STAT. 2010. PROCLAMATION 5295-JAN. 29, 1985. Americans have one or more forms of heart or blood vessel disease. Strokes afflict almost two million people annually. As many as 1.5 million persons will have a heart attack this year, and approximately 550,000 of them will die. In all, diseases of the heart and blood vessels will take the lives of almost one million of our fellow citizens-some of whom may be our family members, our friends and our co-workers. Almost as many people will die from cardiovascular disease during 1985 as from cancer, accidents, and all other causes combined. Economic losses will also run high. This Nation will spend an estimated $72 billion in 1985 for medical treatment, lost salaries, rehiring and training, and insurance and disability claims resulting from heart and blood vessel disease. The American Heart Association, a not-for-profit volunteer health agency, and the Federal government, primarily through the National Heart, Lung and Blood Institute, are providing ...
Dr Suresh Rama Chandran, Associate Consultant from the Department of Endocrinology at Singapore General Hospital, a member of the SingHealth group, shares how diabetes can affect our kidneys, nerve, heart and blood vessels.
There is an increased incidence of heart failure in individuals with diabetes mellitus (DM). The co-existence of kidney disease in DM exacerbates the cardiovascular prognosis. Researchers have attempted to combine the critical features of heart failure, using transverse aortic constriction, with DM in mice but variable findings have been reported. Furthermore, kidney outcomes have not been assessed in this setting thus its utility as a model of heart failure in DM and kidney disease is unknown. We generated a mouse model of obesity, hyperglycemia and mild kidney pathology by feeding male C57BL/6J mice a high fat diet (HFD ...
We offer adventurous nature enthusiasts sea trips from 15 May until 15 September 2015; trips take place on board a small vessel. The trip begins at Kärdla harbour. During the trip, we are going to observe...
缺乏維生素B12 和 小間隙腦中風後之疲倦和憂鬱的關聯 (以上標題清楚。以下請自檢查,各專有名次翻譯、順序)小間隙腦中風 (Lacunar stroke) 之定義:急性的中風。症狀 ... ...
TY - JOUR. T1 - Clinically probable brainstem stroke presenting primarily as dysphagia and nonvisualized by MRI. AU - Buchholz, David. PY - 1993/6. Y1 - 1993/6. N2 - Ten patients with clinically probable brain-stem stroke presenting primarily as acute dysphagia but without visible brainstem abnormality by MRI are described. The patients were evaluated with neurologic examinations, cinepharyngoesophagography, and brain MRI studies. Each patient solely or predominately experienced sudden pharyngeal dysphagia, and additional symptoms or signs other than dysphonia or dysarthria were scarce. Small vessel disease or cardiac embolism were the apparent causes of what appear to have been very discrete brainstem strokes in these patients. Acute pharyngeal dysphagia can be the sole or primary manifestation of brainstem stroke. A negative MRI study should not preclude consideration of this diagnosis, if brainstem stroke is otherwise clinically probable.. AB - Ten patients with clinically probable brain-stem ...
Lacunar stroke or lacunar infarct (LACI) is the most common type of stroke, and results from the occlusion of small penetrating arteries that provide blood to the brains deep structures. Patients who present with symptoms of a lacunar stroke, but who have not yet had diagnostic imaging performed, may be described as suffering from lacunar stroke syndrome (LACS). Much of the current knowledge of lacunar strokes comes from C. Miller Fishers cadaver dissections of post-mortem stroke patients. He observed "lacunae" (empty spaces) in the deep brain structures after occlusion of 200-800 μm penetrating arteries and connected them with five classic syndromes. These syndromes are still noted today, though lacunar infarcts are diagnosed based on clinical judgment and radiologic imaging. Each of the 5 classical lacunar syndromes has a relatively distinct symptom complex. Symptoms may occur suddenly, progressively, or in a fluctuating (e.g., the capsular warning syndrome) manner. Occasionally, cortical ...
What is Cardiovascular Disease?. Cardiovascular disease (CVD) refers to health conditions of the heart and blood vessels. This includes stroke, heart failure, coronary heart disease and cardiomyopathy to name a few.. Am I at Risk of Cardiovascular Disease?. There are many factors that can increase your chances of cardiovascular disease, some of which cannot be changed, such as getting older and family history, and some of which can, including smoking, physical inactivity, poor nutrition, high blood pressure, high blood cholesterol and obesity.. Five Year Risk Calculator - Heart and Stroke Risk. If you know a few numbers including your age, blood pressure and cholesterol you can find out your CVD risk by clicking the link below for the National Vascular Disease Prevention Alliance Calculator.. ...
But ironically, hypertension until ≥ 200/120 also sometimes does not give any symptoms! Or in most cases, people are just complaining mild dizziness and mild aches. Either know or not the actual impact hypertension has occurred when pressure ≥ 120/80; effect the damage will accumulate until many years later a new cause of heart and blood vessel disease. Especially for hypertensive crisis, the danger of stroke, heart disease, and blood vessel rupture can threaten at any time ...
Nearly Half of People Who Need Cholesterol Treatment Dont Get It Nearly Half of People Who Need Cholesterol Treatment Dont Get It WINSTON-SALEM, N.C. - Even though treatment for cholesterol disorders can reduce the risk of heart and blood vessel disease by about 30 percent over five years, many at-risk
Visit your doctor or health care professional for regular checks on your progress. Your blood sugar and other tests will be measured regularly.. This medicine is only part of a total cholesterol or blood sugar-lowering program. Your health care professional or dietician can suggest a low-cholesterol and low-fat diet that will reduce your risk of getting heart and blood vessel disease. Avoid alcohol and smoking, and keep a proper exercise schedule.. To reduce the chance of getting constipated, drink plenty of water and increase the amount of fiber in your diet. Ask your doctor or health care professional for advice if you are constipated.. If you are taking this medicine for diabetes, wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.. ...
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Dr. Lim said this research has the potential to greatly impact patient care. "Since there is currently a lack of therapeutics for the treatment of small vessel occlusions, which commonly occur in diabetic patients, this research could provide a new therapy for those patients," Dr. Lim said. "Oral FAK inhibitors are currently being tested in human clinical trials as a cancer therapy; they might also prove helpful in treating these vascular complications ...
We found that higher cystatin C concentrations showed a greater association with severe CMB pathology especially in patients of the highest quartile. One standard deviation increase in the log-transformation of cystatin C levels also showed a closer relationship with severe CMBs. The estimated GFR and microalbumin/creatinine ratio failed to show a significant association with the number of CMBs. Moreover, the association was sustained in patients with deep or infratentorial CMBs but not among those with strictly lobar CMBs. In addition, the correlation between the CMB grades and cystatin C in patients with lacunar stroke showed a stronger association than that in patients with non lacunar stroke. Cystatin C was the most powerful indicator for CMBs among the three renal markers. Our results corroborate previous studies showing that renal dysfunction is independently associated with CMBs [8, 29]. Furthermore, we showed that cystatin C may reflect the severity of CMBs in a dose dependent manner ...
View Notes - Abstract for Annotated Source Geneology from NURSING Nursing at Kentucky. abnormal in 55%. Brain MRI in 35 children demonstrated white matter lesions separate from the optic nerves in
This study took advantage of the prospective accumulation of data in 493 patients who had clinical and radiologic evidence suggesting that their hemispheric ischemic events were of lacunar type. Caution must be exercised in making comparisons between the current observations and other reports in the literature. First, patients in the nonlacunar "control" group in this study had overt evidence of large-artery disease and did not consist of the usual normal subjects with whom lacunar syndromes have been compared previously. Second, no patients were accepted into the current study who failed to fulfill the clinical criteria for lacunar syndromes. Unlike other reports appearing in the literature, patients with radiologic findings alone were not considered to have lacunar strokes. Lastly, the definition of a lacunar stroke is an evolving process. There is uncertainty with regard to considering lacunar strokes that involve clinically one body area alone. In the current study these patients were ...

Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease |...Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease |...

Keywords: Cerebral small vessel disease, cognition, enlarged perivascular spaces, hypertension, lacunar stroke, white matter ... Keywords:Cerebral small vessel disease, cognition, enlarged perivascular spaces, hypertension, lacunar stroke, white matter ... Abstract:Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to ... Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to cSVD ...
more infohttp://www.eurekaselect.com/120839/article?tracking-code=4

Hypercholesterolemia induced cerebral small vessel diseaseHypercholesterolemia induced cerebral small vessel disease

... its significance for cerebral small vessel disease (CSVD) remains unclear. We thus aimed to understand the detailed ... We analyzed cerebral capillaries and arterioles for intravascular erythrocyte accumulations, thrombotic vessel occlusions, ... Background While hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, ...
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182822

Cerebral small vessel disease | Neurology and clinical neuroscience | Cambridge University PressCerebral small vessel disease | Neurology and clinical neuroscience | Cambridge University Press

Clinical Aspects of Cerebral Small Vessel Disease:. 18. Acute stroke syndromes caused by small vessel disease Mark I. Boulos, ... 7. Pathogenic aspects of hereditary small vessel disease of the brain Anne Joutel. 8. Hereditary cerebral small vessel disease ... 1. Definition and classification of small vessel diseases Leonardo Pantoni. 2. Pathology of cerebral small vessel disease Jun ... Experimental animal models of cerebral small vessel disease Atticus H. Hainsworth and Hugh S. Markus. 6. Sporadic small vessels ...
more infohttps://www.cambridge.org/af/academic/subjects/medicine/neurology-and-clinical-neuroscience/cerebral-small-vessel-disease?format=HB

C-Reactive Protein and Cerebral Small-Vessel Disease | CirculationC-Reactive Protein and Cerebral Small-Vessel Disease | Circulation

Whether these processes are also involved in cerebral small-vessel disease is unknown. Cerebral white matter lesions and ... C-Reactive Protein and Cerebral Small-Vessel Disease. The Rotterdam Scan Study. E. J. van Dijk, N. D. Prins, S. E. Vermeer, H. ... C-Reactive Protein and Cerebral Small-Vessel Disease. E. J. van Dijk, N. D. Prins, S. E. Vermeer, H. A. Vrooman, A. Hofman, P. ... C-Reactive Protein and Cerebral Small-Vessel Disease. E. J. van Dijk, N. D. Prins, S. E. Vermeer, H. A. Vrooman, A. Hofman, P. ...
more infohttp://circ.ahajournals.org/content/112/6/900

Type 1 diabetes raises risk for cerebral small-vessel diseaseType 1 diabetes raises risk for cerebral small-vessel disease

... and cerebral micro-bleeds, in particular, than those without diabetes, according to findings published in Diabetes Care. ... Adults with type 1 diabetes are more likely to develop cerebral small-vessel disease, ... Adults with type 1 diabetes are more likely to develop cerebral small-vessel disease, and cerebral micro-bleeds, in particular ... In the diabetes group with cerebral small-vessel disease, 45 (24%) had cerebral micro-bleeds and 44 (23%) had white matter ...
more infohttps://www.healio.com/endocrinology/diabetes/news/in-the-journals/%7B32de9cdd-38ab-4ae4-9753-928de285f18b%7D/type-1-diabetes-raises-risk-for-cerebral-small-vessel-disease

Longitudinal Relationship Between Cerebral Small-Vessel Disease and Cerebral Blood Flow | StrokeLongitudinal Relationship Between Cerebral Small-Vessel Disease and Cerebral Blood Flow | Stroke

Longitudinal Relationship Between Cerebral Small-Vessel Disease and Cerebral Blood Flow. Pieternella H. van der Veen, Majon ... Longitudinal Relationship Between Cerebral Small-Vessel Disease and Cerebral Blood Flow. Pieternella H. van der Veen, Majon ... Longitudinal Relationship Between Cerebral Small-Vessel Disease and Cerebral Blood Flow. The Second Manifestations of Arterial ... Background and Purpose-Cerebral small-vessel disease and cerebral blood flow (CBF) are interrelated. However, the direction of ...
more infohttp://stroke.ahajournals.org/content/46/5/1233

Gait in Elderly With Cerebral Small Vessel Disease | StrokeGait in Elderly With Cerebral Small Vessel Disease | Stroke

Gait in Elderly With Cerebral Small Vessel Disease. Karlijn F. de Laat, Anouk G.W. van Norden, Rob A.R. Gons, Lucas J.B. van ... Gait in Elderly With Cerebral Small Vessel Disease. Karlijn F. de Laat, Anouk G.W. van Norden, Rob A.R. Gons, Lucas J.B. van ... Gait in Elderly With Cerebral Small Vessel Disease. Karlijn F. de Laat, Anouk G.W. van Norden, Rob A.R. Gons, Lucas J.B. van ... Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ...
more infohttp://stroke.ahajournals.org/content/early/2010/06/24/STROKEAHA.110.583229

Structural network changes in cerebral small vessel disease | Journal of Neurology, Neurosurgery & PsychiatryStructural network changes in cerebral small vessel disease | Journal of Neurology, Neurosurgery & Psychiatry

Cerebral small vessel disease: from a focal to a global perspective. Nat Rev Neurol2018;14:387-98.doi:10.1038/s41582-018-0014-y ... Cerebral small vessel disease (SVD) is a common finding on brain imaging in older adults and plays a pivotal role in the ... Automated detection of white matter hyperintensities of all sizes in cerebral small vessel disease. Med Phys2016;43:6246-58.doi ... Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease. Neurology2017;89:1869-76.doi:10.1212/ ...
more infohttps://jnnp.bmj.com/content/early/2019/11/18/jnnp-2019-321767

Structural network changes in cerebral small vessel disease | Journal of Neurology, Neurosurgery & PsychiatryStructural network changes in cerebral small vessel disease | Journal of Neurology, Neurosurgery & Psychiatry

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Role of COL4A1 in basement-membrane integrity and cerebral small-vessel disease. The COL4A1 stroke syndrome.  - PubMed - NCBIRole of COL4A1 in basement-membrane integrity and cerebral small-vessel disease. The COL4A1 stroke syndrome. - PubMed - NCBI

Role of COL4A1 in basement-membrane integrity and cerebral small-vessel disease. The COL4A1 stroke syndrome.. Volonghi I1, ... have been linked to a spectrum of cerebral small-vessel disease in humans, including perinatal intracerebral hemorrhage (ICH) ... questions concerning the possible genotype-phenotype correlations and the mechanisms leading to cerebral small-vessel disease ... Although pathological changes in BM also occur in other tissues (mostly retina and kidney), the major site of vessel damage is ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/20166936?dopt=Abstract

Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease - Nitkunan - 2008 - NMR in...Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease - Nitkunan - 2008 - NMR in...

Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease. Authors. *. Arani Nitkunan,. ... Cerebral small vessel disease (SVD) is an important cause of cognitive impairment, but the pathophysiological mechanisms remain ... Ai-Juan Zhang, Xin-Jun Yu, Mei Wang, The clinical manifestations and pathophysiology of cerebral small vessel disease, ... Consensus statement for diagnosis of subcortical small vessel disease, Journal of Cerebral Blood Flow & Metabolism, 2016, 36, 1 ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/nbm.1322/abstract

RePub, Erasmus University Repository:
  Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based StudiesRePub, Erasmus University Repository: Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies

Cerebral small vessel diseases, Epidemiology, Stroke, lacunar, Leukoaraiosis Persistent URL. dx.doi.org/10.5853/jos.2018.03608, ... Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies. Publication. Publication. Journal of Stroke ... Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity ... Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies. Journal of Stroke, 21(2), 121-138. doi: ...
more infohttps://repub.eur.nl/pub/116968

Juxtacortical lesions are associated with seizures in cerebral small vessel disease | Springer for Research & DevelopmentJuxtacortical lesions are associated with seizures in cerebral small vessel disease | Springer for Research & Development

Background and objective Small vessel cerebrovascular disease (SVCD) can manifest with epileptic seizures and transient ... Cerebral small vessel diseases Seizures Transient ischemic attack Magnetic resonance imaging This is a preview of subscription ... Arba F, Quinn T, Hankey GJ et al (2017) Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in ... Small vessel cerebrovascular disease (SVCD) can manifest with epileptic seizures and transient ischemic attacks (TIA). This ...
more infohttps://rd.springer.com/article/10.1007%2Fs00415-019-09253-9

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats | Science...Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats | Science...

Cerebral small vessel disease (SVD) affects the small perforating arterioles in the brain and is the leading cause of vascular ... Genetic factors in cerebral small vessel disease and their impact on stroke and dementia. J. Cereb. Blood Flow Metab. 36, 158- ... Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain 128, 2034-2041 ... Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 134, 73-83 (2011).. ...
more infohttps://stm.sciencemag.org/content/10/448/eaam9507.full?ijkey=wHyq.wAUONZi.&

Fondation Leducq   -  Understanding the role of the perivascular space in cerebral small vessel diseaseFondation Leducq - Understanding the role of the perivascular space in cerebral small vessel disease

Small vessel diseases (SVDs) are a group of disorders that result from pathological alteration of the small blood vessels in ... Fondation Leducq / Research Highlight / Understanding the role of the perivascular space in cerebral small vessel disease ... Understanding the role of the perivascular space in cerebral small vessel disease. ... The pathophysiological signature of PVS and what this infers about their function and interaction with cerebral ...
more infohttps://www.fondationleducq.org/highlight/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease/

Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease LoadArterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load

We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white ... Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load. ... The load of the disease was calculated using an ordinal scale ranging from 0 to 4 (1 point was given for each of the 4 markers ...
more infohttps://insights.ovid.com/stro/201805000/00007670-201805000-00036

Frontiers | Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in...Frontiers | Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in...

... cerebral microbleeds and perivascular spaces, which are MRI markers of cerebral small vessel disease (SVD). Studies have shown ... which are MRI markers of cerebral small vessel disease (SVD). Studies have shown associations between these individual MRI ... 2011). Does cerebral small vessel disease predict future decline of cognitive function in elderly people with type 2 diabetes? ... Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with ...
more infohttps://www.frontiersin.org/articles/10.3389/fnagi.2016.00301/full

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats | Science...Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats | Science...

Endothelial cell-stabilizing drugs reverse white matter pathology in a rat model of cerebral small vessel disease. ... Endothelial cell-stabilizing drugs reverse white matter pathology in a rat model of cerebral small vessel disease. ... Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats ... Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats ...
more infohttps://stm.sciencemag.org/content/10/448/eaam9507/tab-figures-data

Occurrence of cerebral small vessel disease at diagnosis of MPO-ANCA-associated vasculitis | Springer for Research & DevelopmentOccurrence of cerebral small vessel disease at diagnosis of MPO-ANCA-associated vasculitis | Springer for Research & Development

However, little is known about subclinical involvements of the... ... Occurrence of cerebral small vessel disease at diagnosis of MPO ... Wada M, Nagasawa H, Kurita K, Koyama S, Arawaka S, Kawanami T, Tajima K, Daimon M, Kato T (2008) Cerebral small vessel disease ... Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. ... We investigated the frequency and progression of cerebral small vessel disease (SVD) in patients with AAV. ...
more infohttps://rd.springer.com/article/10.1007%2Fs00415-019-09318-9

Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical...Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical...

Aim: We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial ... The association between lung function impairment and cerebral small vessel disease did not change after further adjusting for ... Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical ...
more infohttps://www.jstage.jst.go.jp/article/jat/25/10/25_42127/_article

Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in patients with ischaemic stroke and...Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in patients with ischaemic stroke and...

Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in patients with ischaemic stroke and ... Small vessel disease (SVD) and Alzheimers disease (AD) are two common causes of cognitive impairment and dementia, ... In patients with ischaemic cerebrovascular disease, SVD features are associated with MTA, which is a common finding in stroke ...
more infohttps://insights.ovid.com/ejneu/201702000/00054821-201702000-00010

Supplementary Material for: Cerebral Small Vessel Disease Is Associated with Dysregulation in the Ubiquitin Proteasome System...Supplementary Material for: Cerebral Small Vessel Disease Is Associated with Dysregulation in the Ubiquitin Proteasome System...

Cerebral Small Vessel Disease Is Associated with Dysregulation in the Ubiquitin Proteasome System and Other Major Cellular ... Supplementary Material for: Cerebral Small Vessel Disease Is Associated with Dysregulation in the Ubiquitin Proteasome System ... p,,b,,i,Background/Aims:,/i,,/b, Cerebral small vessel disease (SVD) is characterized by periventricular white matter (WM) ... Vessel-associated functions, such as increased extracellular matrix-receptor interactions and cell adhesion molecules, were ...
more infohttps://figshare.com/articles/Supplementary_Material_for_Cerebral_Small_Vessel_Disease_Is_Associated_with_Dysregulation_in_the_Ubiquitin_Proteasome_System_and_Other_Major_Cellular_Pathways_in_Specific_Brain_Regions/5311228/1

Small vessel disease burden in cerebral amyloid angiopathy without symptomatic hemorrhage | NeurologySmall vessel disease burden in cerebral amyloid angiopathy without symptomatic hemorrhage | Neurology

Small vessel disease burden in cerebral amyloid angiopathy without symptomatic hemorrhage. Gregoire Boulouis, Andreas ... Small vessel disease burden in cerebral amyloid angiopathy without symptomatic hemorrhage. Gregoire Boulouis, Andreas ...
more infohttps://n.neurology.org/content/88/9/878/tab-figures-data

Cerebral Small Vessel Diseases | MetaCerebral Small Vessel Diseases | Meta

Cerebral small vessel disease (CSVD) includes several diseases affecting the small arteries, arterioles, venules, and ... Hemorrhagic cerebral small vessel disease caused by a novel mutation in 3 UTR of collagen type IV alpha 1. Neurology. Genetics ... feed-previews/cerebral-small-vessel-diseases/f04af9b3-71b8-4dc2-9929-41669791a89e. ... Cerebral small vessel disease due to a unique heterozygous HTRA1 mutation in an African man. Neurology. GeneticsFebruary 12, ...
more infohttps://www.meta.org/feed-previews/cerebral-small-vessel-diseases/f04af9b3-71b8-4dc2-9929-41669791a89e

Cerebral hemodynamics in cerebral small vessel disease - Oxford NeuroscienceCerebral hemodynamics in cerebral small vessel disease - Oxford Neuroscience

In addition, cerebral arteriopathy underlying SVD may also impair the ability of small cerebral vessels to vasodilate, leading ... Impairments of cerebral reactivity to vasodilatory stimuli [1] and of cerebral autoregulation [2] have been shown in animal ... We review the different techniques that can be used to measure CBF, cerebral reactivity, and cerebral autoregulation. We then ... would be consistent with disease occurring due to hypoperfusion. This has led to the suggestion that cerebral blood flow (CBF) ...
more infohttps://www.neuroscience.ox.ac.uk/publications/445807
  • Multivariate analysis revealed juxtacortical small lesions as strong independent predictor (OR, 95% CI 12.8, 6.7-24.3) and medial temporal lobe atrophy as further independent predictor of FIAS (3.1, 1.3-7.1). (springer.com)
  • Juxtacortical small lesions and to a smaller extent medial temporal lobe atrophy are associated with epileptic seizures in elderly patients at a high cardiovascular risk. (springer.com)
  • Department of Experimental Neurology, KULeuven and Leuven Research Institute for Neuroscience and Disease, University of Leuven, Leuven, Belgium (V.T. (cdc.gov)
  • William F. Hoyt was the first to call the syndrome "Susac syndrome" and later Robert Daroff asked Dr. Susac to write an editorial in Neurology about the disorder and to use the eponym of Susac syndrome in the title, forever linking this disease with him. (wikipedia.org)
  • Narrowing of the vascular lumen and failure of cerebral autoregulation result in ischemic damage of the cerebral white and subcortical gray matter. (ahajournals.org)
  • Our results indicate that cerebral SVD starts early in type 1 diabetes but is not explained solely by diabetes-related vascular risk factors or the generalized microvascular disease that takes place in diabetes," the researchers wrote. (healio.com)
  • Mutations replacing a highly conserved hydrophobic glycine residue likely lead to synthesis of an abnormal protein with abnormal structure and inhibit heterotrimer secretion into the vascular BM, modify its structural properties (when imaged with electron microscopy BM is uneven, with inconsistent density and focal disruptions), and, thus, increase the fragility of the vessel wall when exposed to environmental factors. (nih.gov)
  • Multiple cerebral ischemic events may lead to subcortical ischemic depression, also known as vascular depression. (wikipedia.org)
  • The lack of correlation with cognition does not support the use of MRS as a surrogate disease marker. (wiley.com)
  • Inflammatory events are associated with the occurrence of cerebral SVD before clinical diagnosis of MPO-ANCA-positive AAV. (springer.com)