Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Bleeding or escape of blood from a vessel.
The arterial blood vessels supplying the CEREBRUM.
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
Bleeding within the SKULL that is caused by systemic HYPERTENSION, usually in association with INTRACRANIAL ARTERIOSCLEROSIS. Hypertensive hemorrhages are most frequent in the BASAL GANGLIA; CEREBELLUM; PONS; and THALAMUS; but may also involve the CEREBRAL CORTEX, subcortical white matter, and other brain structures.
The susceptibility of CAPILLARIES, under conditions of increased stress, to leakage.
Radiography of the vascular system of the brain after injection of a contrast medium.
A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.
Bleeding from the vessels of the retina.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
Bleeding into one or both CEREBRAL HEMISPHERES due to TRAUMA. Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. Depending on the severity of bleeding, clinical features may include SEIZURES; APHASIA; VISION DISORDERS; MOVEMENT DISORDERS; PARALYSIS; and COMA.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.
Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846)
A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Elements of limited time intervals, contributing to particular results or situations.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is the most frequently seen isolate of that group, has a proclivity for abscess formation, and is most often isolated from the blood, gastrointestinal, and urogenital tract.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Hemorrhage into the VITREOUS BODY.
Intraocular hemorrhage from the vessels of various tissues of the eye.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Disease having a short and relatively severe course.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.
Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
Veins draining the cerebrum.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Agents that prevent clotting.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Bleeding within the subcortical regions of cerebral hemispheres (BASAL GANGLIA). It is often associated with HYPERTENSION or ARTERIOVENOUS MALFORMATIONS. Clinical manifestations may include HEADACHE; DYSKINESIAS; and HEMIPARESIS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
An infant during the first month after birth.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The return of a sign, symptom, or disease after a remission.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Hemorrhage from the vessels of the choroid.
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.
Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS; INTERNAL CAPSULE; PUTAMEN; SEPTAL NUCLEI; GYRUS CINGULI; and surfaces of the FRONTAL LOBE and PARIETAL LOBE.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Intracranial bleeding into the PUTAMEN, a BASAL GANGLIA nucleus. This is associated with HYPERTENSION and lipohyalinosis of small blood vessels in the putamen. Clinical manifestations vary with the size of hemorrhage, but include HEMIPARESIS; HEADACHE; and alterations of consciousness.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Accumulation of blood in the SUBDURAL SPACE between the DURA MATER and the arachnoidal layer of the MENINGES. This condition primarily occurs over the surface of a CEREBRAL HEMISPHERE, but may develop in the spinal canal (HEMATOMA, SUBDURAL, SPINAL). Subdural hematoma can be classified as the acute or the chronic form, with immediate or delayed symptom onset, respectively. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.
Hemorrhage within the orbital cavity, posterior to the eyeball.
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
Radiography of the ventricular system of the brain after injection of air or other contrast medium directly into the cerebral ventricles. It is used also for x-ray computed tomography of the cerebral ventricles.
Dominance of one cerebral hemisphere over the other in cerebral functions.
Bleeding within the brain as a result of penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA. Traumatically induced hemorrhages may occur in any area of the brain, including the CEREBRUM; BRAIN STEM (see BRAIN STEM HEMORRHAGE, TRAUMATIC); and CEREBELLUM.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
A scale that assesses the response to stimuli in patients with craniocerebral injuries. The parameters are eye opening, motor response, and verbal response.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.

Suicide after traumatic brain injury: a population study. (1/39)

OBJECTIVES: To determine the rates of suicide among patients who have had a traumatic brain injury. METHODS: From a Danish population register of admissions to hospital covering the years 1979-93 patients were selected who had had either a concussion (n=126 114), a cranial fracture (n=7560), or a cerebral contusion or traumatic intracranial haemorrhage (n=11 766). All cases of deaths by the end of the study period were identified. RESULTS: In the three diagnostic groups there had been 750 (0.59%), 46 (0.61%), and 99 (0.84%) cases of suicide respectively. Standardised mortality ratios, stratified by sex and age, showed that the incidence of suicide among the three diagnostic groups was increased relative to the general population (3.0, 2.7, and 4.1 respectively). In all diagnosis groups the ratios were higher for females than for males, and lower for patients injured before the age of 21 or after the age of 60. The presence of a codiagnosis relating to substance misuse was associated with increased suicide rates in all diagnosis groups. There was a tendency, among patients with cerebral contusions or traumatic intracranial haemorrhages, for suicide risk to increase with duration of stay in hospital. Cox regression analyses for proportional hazards confirmed that there was a significantly greater risk of suicide among patients with cerebral contusions or traumatic intracranial haemorrhages than among patients with concussion or cranial fractures (hazard ratios=1.42 and 1.50 respectively). There was, however, no evidence of a specific risk period for suicide after injury. CONCLUSION: The increased risk of suicide among patients who had a mild traumatic brain injury may result from concomitant risk factors such as psychiatric conditions and psychosocial disadvantage. The greater risk among the more serious cases implicates additionally the physical, psychological, and social consequences of the injuries as directly contributing to the suicides.  (+info)

The structural basis of moderate disability after traumatic brain damage. (2/39)

The objective was to discover the nature of brain damage in survivors of head injury who are left with moderate disability. Macroscopic and microscopic examination was carried out on the brains of 20 persons who had died long after a head injury that had been treated in a neurosurgical unit. All had become independent but had various disabilities (moderate disability on the Glasgow outcome scale) Most deaths had been sudden, which had led to their referral from forensic pathologists. Post-traumatic epilepsy was a feature in 75%. An intracranial haematoma had been evacuated in 75%, and in 11 of the 15 with epilepsy. Diffuse axonal injury was found in six patients, five of the mildest type (grade 1) and one of grade 2. No patient had diffuse thalamic damage but one had a small focal ischaemic lesion in the thalamus. No patient had severe ischaemic brain damage, but three had moderate lesions which were bilateral in only one. No patient had severe cortical contusions. In conclusion, the dominant lesion was focal damage from an evacuated intracranial haematoma. Severe diffuse damage was not found, with diffuse axonal injury only mild and thalamic damage in only one patient.  (+info)

Giant cell glioblastoma manifesting as traumatic intracerebral hemorrhage--case report. (3/39)

A 33-year-old male presented with intracerebral hemorrhage in the left temporoparietal region after a traffic accident. Ten months later, the traumatic hemorrhage was found to originate in an underlying giant cell glioblastoma. Our case indicates that non-traumatic underlying pathologies, such as vasculopathies, coagulopathies, or tumors, should be considered in the differential diagnoses of intracerebral hemorrhage occurring in unusual locations after traumatic accidents.  (+info)

Magnetization transfer MR imaging in patients with posttraumatic epilepsy. (4/39)

BACKGROUND AND PURPOSE: Intractable epilepsy is a well-recognized complication following head trauma, and many factors have been implicated in its pathogenesis. This study was performed to determine the severity of tissue damage after severe head injury as assessed with magnetization transfer (MT) MR imaging and the relationship of this damage with seizure intractability. METHODS: Forty-four patients, 13 without seizures (disease controls) and 31 with seizures, underwent T1-weighted MT MR imaging 1-10 years after head trauma. Phase-corrected gradient-echo (GRE) imaging was also performed in all patients to look for the presence of hemosiderin. All patients were evaluated for the presence of an MT abnormality beyond an abnormality seen on T2-weighted images, an MT abnormality within a T2 abnormality, and hemosiderin deposition. RESULTS: Patients with an MT abnormality beyond a T2 abnormality had a significantly higher intractability of seizures compared with those with an MT abnormality within a T2 abnormality (P <.05). In addition, the mere presence of hemosiderin deposit was not associated with seizure intractability; however, gliosis around the hemosiderin as seen on T1-weighted MT images was associated with seizure intractability. CONCLUSIONS: T1-weighted MT imaging may be of value in predicting the intractability of the seizure in delayed posttraumatic epilepsy.  (+info)

Acute fatal haemorrhage during percutaneous dilatational tracheostomy. (5/39)

Percutaneous dilatational tracheostomy (PDT) is associated with a number of life-threatening complications. We present a case of massive and fatal arterial haemorrhage that occurred in the intensive care unit during an elective PDT on an 86-year-old woman following earlier evacuation of a traumatic subdural haematoma. An avulsed right subclavian artery was found at post mortem. Previous thyroid surgery and aberrant arterial anatomy contributed to the fatal outcome.  (+info)

Low doses of dexamethasone decrease brain water content of collagenase-induced cerebral hematoma. (6/39)

Different doses of dexamethasone were evaluated for the treatment of cerebral trauma using a rat model of cerebral hematoma induced by intracerebral (IC) stereotaxic injections of collagenase. Control animals received an intracerebral collagenase injection followed by intraperitoneal (IP) saline injection. Sham operated animals received saline only (IC, IP). Forty-eight hours following the surgeries, the brains were removed from the euthanized animals. Cerebral hemispheres were separated and the 4 coronal sections (antero-posterior plane) were weighed. Each slice was dried for 24 h (100 degrees C) and weighed again to establish brain water content. In hematoma-induced saline treated rats, significant differences in brain water content were observed when compared to sham operated animals. Rats treated with 1 mg/kg dexamethasone had a significant brain water content decrease; however, no significant differences were observed with higher doses of dexamethasone. In conclusion, low doses of dexamethasone seem to be beneficial for the treatment of cerebral trauma.  (+info)

Diffuse axonal injury associated with chronic traumatic brain injury: evidence from T2*-weighted gradient-echo imaging at 3 T. (7/39)

BACKGROUND AND PURPOSE: Diffuse axonal injury is frequently accompanied by tissue tear hemorrhages. We examined whether high field strength T2*-weighted gradient-echo imaging performed during the chronic stage of traumatic brain injury may have advantages in the evaluation of diffuse axonal injury as compared with T1- and T2-weighted MR imaging. METHODS: Prospective MR imaging of 66 patients (age range, 17-57 years) was performed using a 3-T system 3 to 292 months (median, 23.5 months) after traumatic brain injury. T1-, T2-, T2*-hypointense and T2-hyperintense foci of 1- to 15-mm diameter were registered in 10 brain regions by two readers separately. Foci that appeared hypointense both on the T1- and T2- and/or on the T2*-weighted images were defined as traumatic microbleeds. RESULTS: For 46 (69.7%) of the patients, T2*-weighted gradient-echo imaging revealed traumatic microbleeds. Hyperintense foci were observed on the T2-weighted images of only 15 (22.7%) patients. T2*-weighted imaging showed significantly more traumatic microbleeds (P =.000) than did T1- and T2-weighted imaging. Interobserver agreement was strong (kappa = 0.79, tau = 0.749, P =.000). For 14 (21.2%) of the patients, T2*-weighted gradient-echo imaging revealed traumatic microbleeds in the corpus callosum, whereas for only two (3%), hyperintense callosal lesions were seen on the T2-weighted images. Although a significant correlation existed between the total amount and callosal appearance of traumatic microbleeds and Glasgow Coma Scale scores (P =.000), no correlation existed with extended Glasgow Outcome Scale scores. CONCLUSION: T2*-weighted gradient-echo imaging at high field strength is a useful tool for the evaluation of diffuse axonal injury during the chronic stage of traumatic brain injury. Diffuse axonal injury-related brain lesions are mainly hemorrhagic. The relevance of diffuse axonal injury for long-term clinical outcome is uncertain.  (+info)

Endovascular management of intracranial pial arterio-venous fistulas. (8/39)

From 1996-2002 we treated 5 consecutive cases of pial fistula. There were 3 patients with a single hole-single channel pial fistula and two patients had a complex pial fistula. Three patients presented with intracerebral hematoma and had a focal neurological deficit. One patient presented with history of seizures and 1 patient had headache. The results of the treatment were analyzed both clinically and angiographically. The follow-up period ranged from 6 months to 6 years. All fistulas were treated with concentrated glue. The glue cast included the distal part of the feeding artery, A-V connection and the proximal part of the vein. Post-embolisation angiography showed complete occlusion of two single-hole fistulas and one complex pial A-V fistula and near total occlusion of one single-hole and one complex pial A-V fistula. Four patients had excellent clinical outcome. One patient with single-hole fistula had a hemorrhagic venous infarct resulting in transient hemiparesis.  (+info)

121 Introduction: Serial changes in cerebral blood flow after intracerebral hemorrhage may influence tissue viability in regions surrounding the hematoma. Non invasive monitoring may assist titration of systolic blood pressure. Purpose: To determine if continuous quantitative electroencephalography percent alpha variability(EEGPAV)can discriminate areas of critically reduced cerebral blood flow (CBF). Methods:Ten patients with traumatic intracerebral hemorrhage underwent combined monitoring of cerebral microdialysis, EEGPAV, and intermittent xenon-computerized tomograhpy to determine if EEGPAV monitoring could determine and monitor cellular distress in the context of oligemia. Critical oligemia was defined as CBF , 25. Time and regional matched samples of EEG, microdialysis and CBF were used to correlate across modalities. Regions adjacent to the hematoma only were studied. Results:Six patients had regional CBF , 25 and 4 , 30 cc/100gm/min. In the low CBF group, the mean regional EEGPAV was 0.11 ...
phdthesis{74ce6a0f-c52f-44ef-87f8-43a867a9df8a, abstract = {[abstract missing]}, author = {Engström, Martin}, isbn = {91-85439-92-4}, issn = {1652-8220}, language = {eng}, publisher = {Department of Clinical Sciences, Lund University}, school = {Lund University}, series = {Lund University Faculty of Medicine Doctoral Dissertation Series}, title = {Progressive Traumatic Intracerebral Contusions - Studies of the correlation to the biochemical environment and the coagulation system.}, volume = {2005:90}, year = {2005 ...
A small number of patients with an apparently minor head injury will develop a life-threatening intracranial hematoma that must be rapidly detected and removed. To assess the risk of a significant intracranial neurosurgical complication after apparently minor head injury, the authors collected data prospectively on 610 patients who had sustained a transient posttraumatic loss of consciousness or other neurological function and who had a Glasgow Coma Scale (GCS) score of 13, 14, or 15 in the emergency room. Skull x-ray films were obtained in 583 patients, 66 of whom (10.8% of the study population) had cranial fractures. Eighteen of the 610 patients (3.0%) required a neurosurgical procedure. Three acute subdural hematomas, one epidural hematoma, and one traumatic intracerebral hematoma required craniotomy. Of the 66 patients who had skull fracture, 7.6% required a craniotomy for intracranial hematoma. Thirteen (19.7%) of the 66 patients with skull fracture required an operative procedure as ...
Author(s): Mendelow DA, Gregson BA, Rowan EN, Francis R, Mitchell P. Publication type: Conference Proceedings (inc. Abstract). Publication status: Published. Conference Name: 11th Symposium of the International Neurotrauma Society Year of Conference: 2014. Pages: A30-A30. ISSN: 1557-9042. Publisher: Mary Ann Liebert, Inc. publishers URL: http://online.liebertpub.com/doi/pdfplus/10.1089/neu.2014.9937. Series Title: Journal of Neurotrauma. ...
A 66-year-old male patient, with an unremarkable past medical history, was admitted via the emergency department with blunt trauma. He presented in shock with an open wound of his left thigh and massive bleeding, suggestive of left femoral vessel injury, along with a traumatic intracerebral hemorrhage, a left femoral mid-shaft fracture and left hip dislocation. His initial blood pressure was 50/20mm Hg and pulse rate was 130/minute. Our trauma team decided to perform REBOA using a RESCUE balloonTM catheter (Tokai Medical Products, Aichi, Japan) and 7 Fr. Radiofocus® Introducer II (Terumo, Tokyo, Japan) via his right common femoral artery, targeting zone III. After performing total inflation of the balloon using normal saline, we checked its position using portable X-ray, and found that the catheter was placed at zone II (Fig. 1). We planned to reposition the REBOA catheter to zone III in the emergency room, however, the patients vital signs worsened and we decided to reposition the catheter in ...
Cayuga Biotech is a startup company developing novel hemostatic drugs and devices to treat uncontrollable bleeding episodes. We envision our product as a universal agent able to generate clots in all bleeding scenarios while minimizing the risk of side effects.. Trauma and hemorrhage are intertwined conditions that account for the number one cause of death and disability worldwide. We are developing treatments that promote hemostasis for both trauma-related hemorrhage and rare, inherited bleeding disorders.. Live to tell the story.. ...
TY - JOUR. T1 - Decompressive craniectomy as the primary surgical intervention for hemorrhagic contusion. AU - Huang, Abel Po Hao. AU - Tu, Yong Kwang. AU - Tsai, Yi Hsin. AU - Chen, Yuan Shen. AU - Hong, Wei Chen. AU - Yang, Chi Cheng. AU - Kuo, Lu Ting. AU - Su, I. Chang. AU - Huang, She Hao. AU - Huang, Sheng Jean. PY - 2008/11/1. Y1 - 2008/11/1. N2 - The standard surgical treatment of hemorrhagic cerebral contusion is craniotomy with evacuation of the focal lesion. We assessed the safety and feasibility of performing decompressive craniectomy and duraplasty as the primary surgical intervention in this group of patients. Fifty-four consecutive patients with Glasgow Coma Scale (GCS) scores of less than or equal to 8, a frontal or temporal hemorrhagic contusion greater than 20 cm3 in volume, and a midline shift of at least 5 mm or cisternal compression on computer tomography (CT) scan were studied. Sixteen (29.7%) underwent traditional craniotomy with hematoma evacuation, and 38 (70.4%) ...
Intracerebral haemorrhage may be visible indefinitely on MRI, due to persistence of haemosiderin in macrophages around the lesion, but it is not clear whether all haemorrhages produce haemosiderin or,
There are no documented side effects of Lutein but it is recommended that you do not Is Beta Carotene Good For Tanning Eye Headlight Lazy Ruckus take too much of the nutrient as it can possibly Hemophilia and color blindness are recessive disorders. Data Cataracts In Infants Related Articles. Is Beta Carotene Good For Tanning Eye Headlight Lazy Ruckus ocular surface disease. Since glaucoma usually causes no symptoms other than vision loss Vision loss caused by glaucoma is permanent. diffuse axonal injury ; cavernoma: Cereal hemorrhagic contusion; Hemorrhagic cereal contusion; Hemorrhagic cereal contusions; This is particularly useful when treating lazy eye in children as they are sometimes reluctant to wear an eye patch.. The consumption of food and medicinal plants with antioxidant properties have proven their efficacy against skin aging and damage from the sun. Porn game: Dream Job The Interview. Ophthalmologist Portland OR - The Eye Clinic P.. Visit our site or call today to learn more about ...
This patient attended after a series of falls. He displayed ongoing confusion and behavioural change while rehabilitating in hospital. The case was discussed with neurosurgery but was managed conservatively. --- Thanks to Dr Gilly Fleming for...
This one took a bit longer to finish, because I have been busy with work and other things, but I will keep going with the 90s ...
Radiographs demonstrating a left orbit floor fracture and associated opacification of the maxillary sinus (hemosinus). These findings were confirmed on CT, which also demonstrated multiple small foci of brain haemorrhagic contusions.
TY - JOUR. T1 - Surgery for intracerebral hematoma. T2 - The search for the elusive right candidate. AU - Rabinstein, Alejandro A.. AU - Wijdicks, Eelco F.M.. PY - 2006/9/1. Y1 - 2006/9/1. N2 - The value of surgery for patients with intracerebral hemorrhage (ICH) remains a topic of debate. Although several studies have been unable to prove the benefit of surgical intervention of ICH, there is available evidence to suggest that some patients may experience favorable outcome with surgery. Identifying optimal candidates and the timing of surgery for the treatment of ICH are crucial issues. Studies have explored the value of early and ultra-early surgical intervention, as well as the role of stereotactic hematoma evacuation. The International Surgical Trial in Intracerebral Hemorrhage suggested that favorable surgical outcome was more likely for patients with superficial hematomas, and patients who underwent craniotomy in the trial seemed to fare better than those treated with other surgical ...
Diffuse axonal injury is a severe form of brain injury which occurs in some traumatic brain injury patients. It results from shearing forces that damage axons.
No diffusion tensor imaging (DTI) study has yet investigated ataxia in diffuse axonal injury (DAI). In the current study, we used DTI to investigate cerebellar peduncle lesions of patients who showed severe ataxia following DAI. Six patients with sev
Intracerebral hematoma (ICH) are socially significant disease with high mortality or severe disability. The classic method of surgical treatment of ICH is wide craniotomy / craniectomy with open evacuation. As a possible ...
Hello. Thanks for writing to us. The sick leave depends on the extent of contusion and if any late symptoms are expected or not. The area of contusion is also very important. The best judgement would be of your treating doctors as he knows how much the damage is. From your symptoms it seems that...
Diffuse axonal injury Diffuse axonal injury (DAI) is one of the most common and devastating types of brain injury (Iwata et al., 2004), occurring in almost
Histology in DAI. A number of histological techniques are available to appreciate sequential pathological changes in axons in diffuse axonal injury. These are primarily aimed at shortening the duration at which the axonal changes are seen and to put them in context to various traumatic and non traumatic conditions so as to differentiate the causative mechanism. Axonal swellings or retraction balls, representing transected axons, are the histological hallmark of axonal injury but are usually not visible before 24 to 36 hours by routine H & E staining or with a myelin stain like Luxol fast blue [2]. Silver staining method can reliably demonstrate axonal swellings within 12 to 18 hours [27]. The method has been found to be more sensitive and reliable as compare to H & E staining. However diffuse staining of axons by silver stains may occasionally make differentiation of injured and irregular axons difficult thereby limiting their practical utility [28]. Injuries to the axons may be detected even ...
Cerebrospinal Fluid Protein Increased & Hypertension & Intracerebral Hematoma Symptom Checker: Possible causes include Cerebral Hemorrhage. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
This months cases include stroke and intracerebral hematoma in a postpartum woman and bacterial meningitis in a 10-year-old girl.
Management Strategies of Intracerebral Hematomas - click here to listen In this podcast, topic editor Dr. Marc Mayberg of The Swedish Neuroscience Institute, Seattle, Washington, speaks with Dr. David Newell, also of The Swedish Neuroscience Institute. They discuss Dr. Newell and colleagues article Minimally Invasive Treatment of Intracranial Hemorrhage which appears in this months issue.
Cerebral contusion, Latin contusio cerebri, a form of traumatic brain injury, is a bruise of the brain tissue. Like bruises in other tissues, cerebral contusion can be associated with multiple microhemorrhages, small blood vessel leaks into brain tissue. Contusion occurs in 20-30% of severe head injuries. A cerebral laceration is a similar injury except that, according to their respective definitions, the pia-arachnoid membranes are torn over the site of injury in laceration and are not torn in contusion. The injury can cause a decline in mental function in the long term and in the emergency setting may result in brain herniation, a life-threatening condition in which parts of the brain are squeezed past parts of the skull. Thus treatment aims to prevent dangerous rises in intracranial pressure, the pressure within the skull. ...
Traumatic brain injuries are one of the most serious types of injuries caused by car accidents. Every year, over a million people suffer a traumatic brain injury.
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TY - JOUR. T1 - Early elective surgical exploration of spontaneous intracerebral hematomas of unknown origin. T2 - Clinical article. AU - Elhammady, Mohamed. AU - Baskaya, Mustafa K.. AU - Heros, Roberto. PY - 2008/12/1. Y1 - 2008/12/1. N2 - Object. The management of non-life threatening spontaneous intraparenchymal hemorrhage with no obvious medical etiology in patients and the lack of findings on images has not been clearly defined. In general, the current practice is to treat these patients conservatively and repeat studies to rule out a treatable cause 6 weeks to 3 months later; more often than not these repeated studies fail to reveal any findings, and the patient is treated conservatively. For years, the senior author (R.C.H.) has treated these patients with early surgical exploration. This study was undertaken prospectively to ascertain the frequency of positive findings during surgical exploration. Methods. Between 2000 and 2007, the authors prospectively collected data from 9 cases (4 ...
Cerebrospinal Fluid Protein Increased & Intracerebral Hematoma Symptom Checker: Possible causes include Cerebral Hemorrhage & Cerebral Thrombosis & Stroke. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Cerebral contusion, Latin contusio cerebri, a form of traumatic brain injury, is a bruise of the brain tissue. Like bruises in other tissues, cerebral contusion can be associated with multiple microhemorrhages, small blood vessel leaks into brain tissue. Contusion occurs in 20-30% of severe head injuries. A cerebral laceration is a similar injury except that, according to their respective definitions, the pia-arachnoid membranes are torn over the site of injury in laceration and are not torn in contusion. The injury can cause a decline in mental function in the long term and in the emergency setting may result in brain herniation, a life-threatening condition in which parts of the brain are squeezed past parts of the skull. Thus treatment aims to prevent dangerous rises in intracranial pressure, the pressure within the skull. ...
Mostly it will prolapse during the passing of stool. Styplon is also found as a haemostatic drug in conjunction with herbal formulation cayenne pepper green tea for hemorrhoids If youre constipated, your GP may prescribe a laxative Laxatives are a type of medicine that can help you empty your bowels. You can simply take a cotton ball and soak it with apple cider vinegar and later apply it directly on the hemorrhoids to get rid of hemorrhoids.
Diffuse Axonal Injury is a brain injury associated most closely with the rotation and disruption of your brain within the cranium. This can cut away, shear or sever the brain axons, which are connecting nerve fibers. Damage such as this is typically difficult to analyze. It is also accompanied by microscopic tears that are difficult to locate from the get go.. If doctors diagnose your case as a mild brain injury you may notice that thus the wounds heal over time. But often, a DAI results in permanent disabilities from loss of consciousness to lifetime coma. Eventually, a fatality could be the nexus of a future wrongful death claim in civil court and even a murder case in criminal court.. Currently, medical science has not discovered a methodology to treat diffuse axonal injuries. But medical experts have observed in some studies that the damage to axons occurs in the first 12 to 24 hours after the head impact. Many are confident that modern advances in science will be able to treat and/or slow ...
Care guide for Contusion In Children. Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
BACKGROUND: Deep brain stimulation (DBS) is a well-established treatment to reduce tremor, notably in Parkinson disease. DBS may also be effective in post-traumatic tremor, one of the most common movement disorders caused by head injury. However, the cohorts of patients often have multiple lesions that may impact the outcome depending on which fiber tracts are affected. CASE DESCRIPTION: A 20-year-old man presented after road traffic accident with severe closed head injury and polytrauma. Computed tomography scan showed left frontal and basal ganglia hemorrhagic contusions and intraventricular hemorrhage. A disabling tremor evolved in step with motor recovery. Despite high-intensity signals in the intended thalamic target, a visual analysis of the preoperative diffusion tensor imaging revealed preservation of connectivity of the intended target, ventralis oralis posterior thalamic nucleus (VOP). This was confirmed by the postoperative tractography study presented here. DBS of the VOP/zona incerta was
Objectives: We sought to describe the frequency and location of headache in intracerebral hematoma (ICH) and to analyze its clinical and CT predictors by means of multivariate analysis. Background: Headache is more common in intracerebral hemorrhage than in ischemic stroke, and its frequency varies with hematoma location, but the pathophysiologic mechanisms of headache associated with ICH are not fully known. Methods: We examined a cohort of 289 patients with ICH during a 14-month period in a university hospital. Clinical, including the presence and location of headache, and CT features were collected by two neurologists. Results: One hundred and sixty-five (57%) patients with ICH had a headache at the onset of their stroke. Headache was more common in cerebellar and lobar hemorrhages than in deep ones (thalamic, caudate, capsuloputaminal, brainstem). Headache was also more common in women, patients younger than 70 years, those who vomited, and those with meningeal signs, a Glasgow Coma Scale ...
Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia. Readouts from the thrombin generation (TG) assay (TGA) have been used to predict the effects of hemostatic drugs in hemophilic patients [1]. There is better correlation between an individuals bleeding tendency and his or her TG capacity compared with factor levels measured using routine assays [2, 3]. However, the clinical utility of TGA has not yet been validated in multicenter studies because of lack of standardization. This report aims to highlight variables that may impact directly on TGA reliability and steps to reduce TGA variability within and between laboratories to improve precision of results. Read more.. ...
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An emerging field of research focuses on using biomarkers as a different non-invasive clinical approach for diagnosis of DAI. These markers could be detected in CSFsamples due to the breakdown products of neurons and diffusion through the damaged blood brain barrier of traumatic brain injury patients. Possible biomarkers could include proteins associated with primary structural damage or with the cellular and molecular cascade involved in secondary axonomy. Axonal and glial biomarkers include neurofilaments (NF), microtubule-associated protein tau, and α-II Spectrin, and myelin basic protein. These are all critical components of the cytoskeleton or myelin that are dephosphorylated, degraded, depolymerized, and form protein bundles upon injury due to the action of proteolytic enzymes. Biomarkers associated with the molecular cascade during secondary axonomy include β-Amyloid precursor protein, an axoplasmic transport protein that accumulates in the retraction balls, amyloid β, FE65, and ...
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Guidelines for the management of severe head injury in adults as evolved by the European Brain Injury Consortium are presented and discussed. The importance of preventing and treating secondary...
TY - JOUR. T1 - Intensive care monitoring of severe head injury. AU - Rafferty, C.. AU - Hansen, S.. AU - Bullock, Ross. AU - Teasdale, G. M.. AU - Fitch, W.. AU - Jamal, G. A.. PY - 1992/1/1. Y1 - 1992/1/1. UR - http://www.scopus.com/inward/record.url?scp=0026696761&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026696761&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0026696761. VL - 3. JO - Clinical Intensive Care. JF - Clinical Intensive Care. SN - 0956-3075. IS - 2 SUPPL.. ER - ...
Scheid, R.; Preul, C.; Gruber, O.; Wiggins, C.; von Cramon, D. Y.: Diffuse axonal injury associated with chronic traumatic brain injury: Evidence from T2*-weighted gradient-echo imaging at 3 T. Meeting of the Deutschen-Gesellschaft-fur-Neurologie, Meeting of the Deutschen-Gesellschaft-fur-Neurologie, 27. September 2009. American Journal of Neuroradiology 24 (6), S. 1049 - 1056 (2004 ...
Can you die from post concussive syndrome - Can you die from post concussive syndrome? Not likely. Post concussive syndrome should not be fatal. Although this is one of the disorders under traumatic brain injury, concussion should not show abnormalities on ct scan or the diagnosis changes to something more severe such as diffuse axonal injury.
Calcium, Concentration, Membrane, Axonal Transport, Axons, Brain, Brain Injury, Calpain, Cell Death, Cytoskeleton, Death, Diffuse Axonal Injury, Future, Injury, Mitochondria, Neurons, Permeability, Poloxamer, Poloxamer 188, Therapeutic
The recently published second Surgical Trial in Intracerebral Haemorrhage (STICH-2) tested whether surgical evacuation of superficial spontaneous intracerebral haemorrhage was effective at reducing death and disability at 6 months after onset. Participants were randomised to a policy of early surgical intervention or initial medical management alone within 48 hours of symptom onset. After enrolling 601 patients across 78 centres in 27 countries, intention to treat analysis showed no difference in outcome. Time to intervention was a median of 26 hours after symptom onset in the surgical arm, and craniotomy accounted for 98% of all surgical procedures. The interpretation of the overall neutral result is confounded by a high proportion of crossovers from the medical management arm of the study, predominantly of more severely affected patients. Further analysis may clarify whether decompressive surgery late after superficial intracerebral haemorrhage has any role in management. ...
But there are cases where hemostatic drugs are contraindicated during menstruation because of allergic reactions to the components or any other intolerance.Then resorted to traditional medicine.Naturally, in such a way hormones do not balance, and narrow vessels is quite real.Great for those purposes a decoction of the bark of Viburnum, nettle infusions and decoctions, tinctures and teas of marigold and others. Yet it is worth recalling that it is better not to self-medicate, and seek medical advice in time for the qualified help.. Hemostatic agents at monthly Sharok presented to pharmacists, but among them are the following: Dicynonum, Traneksan, Vikasol etc.Only a specialist can determine: whether or not to take these drugs, in what dosage and what time.. It should be noted that when an uncontrolled admission of drugs that increase blood clotting and constrict blood vessels, blockage of the veins may occur.Also, these drugs are contraindicated for those who already suffer from thrombosis or ...
Objective: To observe the effects of minimally invasive surgery (MIS) for hematoma of intracerebral hemorrhage (ICH) evacuation followed by rosigli..
We present a case of herpetic meningoencephalitis confirmed by PCR in a 22-y-old male, with accompanying appearance of a large intracerebral haematoma as a complication. Despite the impressive imaging findings, the final outcome of the patients progress was favourable.
Upon my airlift arrival to James Cook university hospital, in Middlesbrough, it was discovered I had a brain injury (cerebral contusion) and L&R lung contusion. Due to the brain injury I was placed in an induced coma with a pressure relief valve screwed into my skull so the cranial pressure did not badly damage the brain. Immediately after the coma I was making an awful noise and had my attention focused on my left leg, so they x-rayed my leg and found out I had badly broken my left femur just by my knee, so I was put back into the coma and had an operation to put 3 screws in my the femur just by the knee. I also broke my neck in three places but just wore a neck brace to keep it straight. ...
HEMATOMA INTRAPARENQUIMATOSA PDF - Neurosurg Focus. Oct 15;15(4):E4. Intracerebral hematoma from aneurysm rupture. Abbed KM(1), Ogilvy CS. Author information: (1)Department of. This
The mRS is a measure of global disability that has been widely applied for evaluating recovery from stroke. Scores range from 0 to 6, with higher scores indicating greater disability. A score of 0 indicates no residual symptoms; 1 = no significant disability/able to carry out all usual activities, despite some symptoms; 2 = slight disability; 3 = moderate disability; 4 = moderately severe disability; 5 = severe disability; 6 = death. The number of participants scoring 0-2 on the mRS at Day 30 was compared in both treatment groups ...
Another name for Thigh Contusion is Leg Contusion. What is a leg contusion? A person with a leg contusion has a bruise to the leg. A leg contusion may ...
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"Detection of delayed cerebral ischemia using objective pupillometry in patients with aneurysmal subarachnoid hemorrhage". ... Ahmadieh, Tarek (2021). "Automated Pupillometry as a Triage and Assessment Tool in Patients with Traumatic Brain Injury" (PDF ... A study published in the Journal of Neurosurgery found that the NPi may signal an early warning of potential delayed cerebral ... Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury. Crit ...
Delayed cerebral infarction after subarachnoid hemorrhage is a major cause of morbidity. Two Phase I clinical trials have shown ... Traumatic brain injury (TBI) shares many pathophysiological pathways with acute stroke, and ischemic preconditioning increases ... Reduced cerebral blood flow is an early finding in vascular cognitive impairment (VCI). Cardiovascular risk factor control is ... Animal models of stroke (both open-skull and closed-skull models) show that RIC improves cerebral blood flow; reduces ischemic ...
Corey suffered a traumatic cerebral hemorrhage at his desk on September 15, 1953, lapsed into a coma, and died the next day. ... After a protracted legal battle, Corey died of a cerebral hemorrhage before the action against him was formally abandoned. ...
He was diagnosed with a severe closed traumatic brain injury, acute subdural hematomas of the head, cerebral hemorrhage, and ...
Cerebral contusion Concussion Diffuse axonal injury Intracranial hemorrhage Traumatic brain injury Ibrahim, Nicole G.; Ralston ... cerebral contusion - a bruise to the brain tissue as a result of trauma. Contusions are local in nature, separating them from ... Multiple mild traumatic brain injuries sustained over a short period of time (hours to weeks), often seen with sports-related ... Blast-related traumatic brain injuries are often closed-head injuries and result from rapid changes in atmospheric pressure, ...
"Clinical relevance of cerebral autoregulation following subarachnoid haemorrhage". Nat. Rev. Neurol. 9 (3): 152-63. doi:10.1038 ... Brain blood flow autoregulation is abolished in several disease states such as traumatic brain injury, stroke, brain tumors, or ... Panerai, R. B.; S. T. Deverson; P. Mahony; P. Hayes; D. H. Evans (1999). "Effect of CO2 on dynamic cerebral autoregulation ... Paulson, O. B.; S. Strandgaard; L. Edvinsson (1990). "Cerebral autoregulation". Cerebrovascular and Brain Metabolism Reviews. 2 ...
In the case of traumatic brain injury or cerebral ischemia (e.g., cerebral infarction or hemorrhage), acute neurodegeneration ... Obrenovitch TP, Richards DA (1995). "Extracellular neurotransmitter changes in cerebral ischaemia". Cerebrovasc Brain Metab Rev ... NR2A subunit of the NMDA glutamate receptor was found to be decreased in a subset of inhibitory interneurons in the cerebral ...
... in Ankara at the building site of Ankara Palas as a result of a cerebral hemorrhage, at the age of 57. He was survived by his ... He lived in a time segment that was as full of joy and ebullience as it was of traumatic disappointments. And his life ended in ...
... traumatic MeSH C21.866.260.118.175.150 - brain stem hemorrhage, traumatic MeSH C21.866.260.118.175.300 - cerebral hemorrhage, ... brain stem hemorrhage, traumatic MeSH C21.866.915.300.200.175.300 - cerebral hemorrhage, traumatic MeSH C21.866.915.300.200.200 ... brain stem hemorrhage, traumatic MeSH C21.866.915.300.490.150.300 - cerebral hemorrhage, traumatic MeSH C21.866.915.300.490.400 ... intracranial hemorrhage, traumatic MeSH C21.866.915.300.490.150 - brain hemorrhage, traumatic MeSH C21.866.915.300.490.150.200 ...
... and intraparenchymal hemorrhage. The recovery of brain function following a traumatic accident is highly variable and depends ... cerebral contusions, and intracranial bleeding, including subarachnoid hemorrhage, subdural hematoma, epidural hematoma, ... "Traumatic Brain Injury". Life in the Fast Lane. Retrieved 13 December 2018. de Mestral C, Sharma S, Haas B, Gomez D, Nathens AB ... Traumatic brain injury (TBI) is a significant cause of morbidity and mortality and is most commonly caused by falls, motor ...
... a fractured skull and a traumatic subarachnoid hemorrhage. 2019 Hoshina made her return to the stage on February 17, 2019, ... While initially the extent of Hoshina's injuries was not made clear, it was later revealed that she had suffered a cerebral ...
... is commonly seen in a variety of brain injuries including ischemic stroke, subarachnoid hemorrhage, traumatic ... Cerebral Edema Cerebral edema is present with many common cerebral pathologies and risk factors for development of cerebral ... intracerebral hemorrhage, cerebral neoplasm. Clinical researches have recommended ICP and cerebral perfusion pressure (CPP) ... In traumatic brain injuries, cerebral edema occurred in greater than 60% of those with mass lesions, and in 15% of those with ...
Pseudosubarachnoid hemorrhages have been observed in as much as 20% of patients resuscitated from non-traumatic cardiopulmonary ... This occurs in cases of severe cerebral edema, such as by cerebral hypoxia. It may also occur due to intrathecally administered ... Patients with pseudosubarachnoid hemorrhages may have worse prognoses than those with true subarachnoid hemorrhages because of ... The identification of a pseudosubarachnoid hemorrhage as opposed to a true subarachnoid hemorrhage may therefore change a ...
It is the only Food and Drug Administration (FDA) approved drug for treating cerebral vasospasm. In traumatic subarachnoid ... Cerebral vasospasm is one of the complications caused by subarachnoid haemorrhage. It usually happens from the third day after ... March 1983). "Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage". The New ... February 2002). "Traumatic subarachnoid hemorrhage: demographic and clinical study of 750 patients from the European brain ...
Early seizures can be caused by factors such as cerebral edema, intracranial hemorrhage, cerebral contusion or laceration. ... PTS may be a risk factor for post-traumatic epilepsy (PTE), but a person who has a seizure or seizures due to traumatic brain ... Post-traumatic seizures (PTS) are seizures that result from traumatic brain injury (TBI), brain damage caused by physical ... Up to 86% of people who have one late post-traumatic seizure have another within two years. Complications of traumatic brain ...
... malignant middle cerebral artery infarction, epidural hematoma, subarachnoid hemorrhage, chronic subdural hematoma, infarction ... The sign can be caused by conditions including traumatic brain injury, stroke, hematoma, or birth deformity that leads to a ... Another use is secondary screening to determine deviations in brain trauma at different times after a traumatic injury as well ... Maas AI, Stocchetti N, Bullock R (August 2008). "Moderate and severe traumatic brain injury in adults". Lancet Neurology. 7 (8 ...
... hemorrhage as an early complication of trauma 958.3 Posttraumatic wound infection not elsewhere classified 958.4 Traumatic ... and strains of other and unspecified parts of back 848 Other and ill-defined sprains and strains 850 Concussion 851 Cerebral ... Traumatic pneumothorax without open wound into thorax 860.1 Traumatic pneumothorax with open wound into thorax 860.2 Traumatic ... 896 Traumatic amputation of foot 897 Traumatic amputation of leg(s) 900 Injury to blood vessels of head and neck 901 Injury to ...
They are caused by a traumatic downward displacement of the brainstem. They are named after Henri Duret. Duret haemorrhages are ... the cerebral crura. Increased pressure above the tentorium may also involve other midbrain structures.[citation needed] ... January 2002). "Brainstem hemorrhage in descending transtentorial herniation (Duret hemorrhage)". Intensive Care Med. 28 (1): ... or acute hematoma, edema following trauma, abscess, or tumor.[citation needed] Duret haemorrhages are haemorrhages secondary to ...
Cerebral aneurysm - Aneurysms of the arteries in the brain most commonly affect the anterior cerebral artery. Rupture of the ... Rupture of the aorta can occur at the sites of aneurysm, but is also due to trauma and results in a traumatic aortic rupture. ... Common signs include Janeway lesions (non-tender), Osler's nodes (tender), and splinter hemorrhage of the nails. Nonbacterial ... Overall, atherosclerosis tends to affect the arteries of highest pressure: aorta, coronary, renal, femoral, cerebral, and ...
... bleeding between the dura mater and the skull Traumatic subarachnoid hemorrhage Cerebral contusion, a bruise of the brain ... Malignant post traumatic cerebral swelling can develop unexpectedly in stable patients after an injury, as can post-traumatic ... Intra-axial hemorrhage is bleeding within the brain itself, or cerebral hemorrhage. This category includes intraparenchymal ... Cerebral concussion is the most common head injury seen in children. Types of intracranial hemorrhage are roughly grouped into ...
... from cerebral embolism) or bleeding (from cerebral hemorrhage). All brain tissue is influenced by blood circulating in the ... This can be especially helpful during the acute phase directly after a stroke or a traumatic brain injury. The measured data is ... Cranial Accelerometry Can Detect Cerebral Vasospasm Caused by Subarachnoid Hemorrhage, Smith et al. (2015) Sun, M; Sekhar, LN; ... ACG also facilitates blood flow analysis as well as the detection of obstructions in cerebral blood flow ( ...
EVDs can be used to monitor intracranial pressure in patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH ... "Continuous cerebral spinal fluid drainage associated with complications in patients admitted with subarachnoid hemorrhage". ... The cerebral perfusion pressure (CPP) can be calculated from data obtained from the EVD and systemic blood pressure. In order ... The risk of hemorrhage with EVD placement is increased if the patient suffers from coagulopathy. Mechanical complications from ...
Cerebral laceration is a brain injury in which the pia-arachnoid is torn. Epidural hemorrhage is bleeding between the dura ... A focal traumatic injury results from direct mechanical forces (such as occur when the head strikes a windshield in a vehicle ... Subdural hemorrhage is bleeding between the dura mater and the arachnoid. Intracerebral hemorrhage is bleeding within the brain ... It is common for both focal and diffuse damage to occur as a result of the same event; many traumatic brain injuries have ...
Intra-axial hemorrhage is bleeding within the brain itself, or cerebral hemorrhage. This category includes intraparenchymal ... "Four Types of Acute Post-Traumatic Intracranial Hemorrhage" The New England Journal of Medicine Capodanno, Davide (July 2018 ... Types of intracranial hemorrhage are roughly grouped into intra-axial and extra-axial. The hemorrhage is considered a focal ... Intra-axial hemorrhages are more dangerous and harder to treat than extra-axial bleeds. Extra-axial hemorrhage, bleeding that ...
Pressure Reactivity-Based Optimal Cerebral Perfusion Pressure in a Traumatic Brain Injury Cohort. Acta Neurochir Suppl. 2018; ... autoregulation in the intensive care setting for patients with severe traumatic brain injury or subarachnoid haemorrhage, in ... CPP values above CPPopt are believed to cause hyperemia, i.e. to high cerebral blood flow that may cause cerebral edema and ... Under normal conditions, cerebral autoregulation ensures that cerebral blood flow is unchanged despite variations in blood ...
"Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial ... of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic ... "Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood ... Pickard, JD; Mackenzie, ET (1973). "Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to ...
Headache attributed to non-traumatic intracranial haemorrhage Headache attributed to intracerebral haemorrhage Headache ... cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) MELAS (eitochondrial encephalopathy ... Acute post-traumatic headache Acute post-traumatic headache attributed to moderate or severe head injury Acute post-traumatic ... post-traumatic headache Chronic post-traumatic headache attributed to moderate or severe head injury Chronic post-traumatic ...
... traumatic MeSH C10.228.140.199.275.200 - brain stem hemorrhage, traumatic MeSH C10.228.140.199.275.300 - cerebral hemorrhage, ... brain stem hemorrhage, traumatic MeSH C10.228.140.300.535.450.200.750 - cerebral hemorrhage, traumatic MeSH C10.228.140.300. ... traumatic MeSH C10.900.300.087.187.200 - brain stem hemorrhage, traumatic MeSH C10.900.300.087.187.300 - cerebral hemorrhage, ... traumatic MeSH C10.900.300.837.150.300 - brain stem hemorrhage, traumatic MeSH C10.900.300.837.150.650 - cerebral hemorrhage, ...
... brain stem hemorrhage, traumatic MeSH C14.907.253.573.400.150.300 - cerebral hemorrhage, traumatic MeSH C14.907.253.573.400.400 ... putaminal hemorrhage MeSH C14.907.253.420.200 - cerebral hemorrhage, traumatic MeSH C14.907.253.459 - brain ischemia MeSH ... putaminal hemorrhage MeSH C14.907.253.573.200.200 - cerebral hemorrhage, traumatic MeSH C14.907.253.573.350 - intracranial ... intracranial hemorrhages MeSH C14.907.253.573.200 - cerebral hemorrhage MeSH C14.907.253.573.200.150 - basal ganglia hemorrhage ...
The most common cause for bleeding into the subarachnoid space is a subarachnoid hemorrhage from a ruptured cerebral aneurysm. ... "traumatic tap") has no time to be metabolized, and therefore no bilirubin is present. After the cerebrospinal fluid is obtained ... van der Wee, N.; Rinkel, G.J.; Hasan, D.; van Gijn J., J. (March 1995). "Detection of Subarachnoid Haemorrhage on Early CT: Is ... The most frequently employed initial test for subarachnoid hemorrhage is a computed tomography scan of the head, but it detects ...
What is Cerebral hemorrhage, traumatic? Meaning of Cerebral hemorrhage, traumatic medical term. What does Cerebral hemorrhage, ... traumatic in the Medical Dictionary? Cerebral hemorrhage, traumatic explanation free. ... Related to Cerebral hemorrhage, traumatic: Traumatic subarachnoid haemorrhage. hemorrhage. [hem´ŏ-rij] the escape of blood from ... cerebral hemorrhage. (redirected from Cerebral hemorrhage, traumatic). Also found in: Dictionary, Thesaurus. ...
Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. Depending on the severity of bleeding, clinical ... Bleeding into one or both CEREBRAL HEMISPHERES due to TRAUMA. ... Traumatic cerebral hemorrhage. Known as: Traumatic Cerebral ... Traumatic Intracerebral Hemorrhage, Hemorrhages, Traumatic Intracerebral (More). Bleeding into one or both CEREBRAL HEMISPHERES ... Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. Depending… (More) ...
Ten patients with traumatic intracerebral hemorrhage underwent combined monitoring of cerebral microdialysis, EEGPAV, and ... Hemorrhage. Detection of critical oligemia in patients with traumatic intracerebral hemorrhage using continuous quantitative ... Introduction: Serial changes in cerebral blood flow after intracerebral hemorrhage may influence tissue viability in regions ... oligemia in patients with traumatic intracerebral hemorrhage using continuous quantitative electroencephalography and cerebral ...
... , Lin Lu, ... TEG, Cerebral traumatic hemorrhage, Blood coagulation function, Predictive function.. Introduction. After cerebral traumatic ... Patients with cerebral traumatic hemorrhage have certain differences with patients with other kinds of traumatic hemorrhage in ... which included 42 patients with cerebral traumatic hemorrhage and 12 with other kinds of traumatic hemorrhage, and 40 were male ...
Traumatic. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Cerebral Hemorrhage, Traumatic. Cerebral hemorrhage - YouTube. A cerebral haemorrhage (also spelled hemorrhage; aka ... Traumatic Subarachnoid Haemorrhage PDF - YouTube. Traumatic Subarachnoid Haemorrhage PDF ... Trauma Biomechanics An ... Fatal Brain Haemorrhage - YouTube. A brain haemorrhage is bleeding in or around the brain, which may be caused by a traumatic ...
Traumatic. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Cerebral Hemorrhage, Traumatic. (Powered by Yahoo! Answers). cerebral hemorrhage?. A 73 yr old women suffers a severe cerebral ... Can you get a cerebral hemorrhage if you were walking and the heel of your high heels break?. Not unless you fell and smacked ... A cerebral hemorrhage is bleeding in the brain. (+ info). 1 2 3 4 5 ...
delayed post-traumatic intra-cerebral haemorrhage. The phenomenon of delayed traumatic haemorrhage - identified in 1891 by ... intra-cerebral haemorrhage. Intra-cerebral haemorrhages may be superficial (in association with contusions) or deep-seated ( ... Intra-cerebral haemorrhages may be primary (i.e. occurring at the time of the trauma) or secondary, due to the effects of ... When an intra-cerebral haemorrhage has been caused by natural disease (such as systemic hypertension, for example), the ...
Hemorrhage and Cerebral Perfusion Are Associated with Brain Volume Decrease in a Cohort of Predominantly Mild Traumatic Brain ... Subarachnoid hemorrhage (SAH) has been shown to affect cerebral volume and perfusion, possibly by induction of inflammation and ... Subarachnoid Hemorrhage and Cerebral Perfusion Are Associated with Brain Volume Decrease in a Cohort of Predominantly Mild ... Keywords: MRI, perfusion, subarachnoid hemorrhage, traumatic brain injury, volume loss, Clinical Neurology ...
Rupture of a fusiform, traumatic, or mycotic aneurysm;. *Pregnancy (confirmed by a serum human chorionic gonadotropin pregnancy ... Evaluation of Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage From a Cerebral ... Subarachnoid Hemorrhage. Vasospasm, Intracranial. Hemorrhage. Pathologic Processes. Intracranial Hemorrhages. Cerebrovascular ... Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage. The safety and scientific ...
Barzo, P. / Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage. ... Barzo, P 2008, Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage ... Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage. Technical case ... Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage. Technical case ...
A. I. Maas, H. F. Lingsma, and B. Roozenbeek, "Predicting outcome after traumatic brain injury," in Handbook of Clinical ... If the SBI is caused by hypertensive cerebral hemorrhage (HCH), it will be defined as hypertensive cerebral hemorrhage SBI (HCH ... The cerebral hemorrhage was the first in 151 cases and the second in 7 cases. Intracerebral hemorrhage of the patients was ... suffering from a cerebral hemorrhage and 147 cases had a higher blood pressure level than normal when the cerebral hemorrhage ...
Method of Post-Traumatic Intracerebral Haematoma (Cerebral Haemorrhage) At present the cerebroprotective effect of a substance ... Animals with cerebral haemorrhage (Group III), * Animals with cerebral haemorrhage which received biological active blood serum ... Animals with cerebral haemorrhage (Group III), * Animals with cerebral haemorrhage which received biological active blood serum ... Method of Post-Traumatic Intracerebral Haematoma (Cerebral Haemorrhage) Cranial trepanation was performed as described in ...
Such injuries include blows to the head, lack of oxygen from suffocation, smoke inhalation or near drowning, hemorrhages, brain ... Traumatic Brain Injury - Any injury to the brain sustained after birth. ... Cerebral Hemorrhages. Hemorrhages of TBI may be outside or inside the brain. Inside the skull the brain is surrounded by a ... Cerebral hemorrhages are named according to their anatomical location:. 1. Epidural hemorrhage: Between the skull and the outer ...
"Detection of delayed cerebral ischemia using objective pupillometry in patients with aneurysmal subarachnoid hemorrhage". ... Ahmadieh, Tarek (2021). "Automated Pupillometry as a Triage and Assessment Tool in Patients with Traumatic Brain Injury" (PDF ... A study published in the Journal of Neurosurgery found that the NPi may signal an early warning of potential delayed cerebral ... Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury. Crit ...
... by a desire to prevent rupture and the devastating morbidity and mortality associated with resulting subarachnoid hemorrhage ( ... which can include cerebral vasospasm, delayed ischemia, seizures, cerebral edema, hydrocephalus, and endocrinologic and ... which can include cerebral vasospasm, delayed ischemia, seizures, cerebral edema, hydrocephalus, and endocrinologic and ... In unruptured cerebral aneurysms, treatment decisions are less clear and currently based solely on treating larger lesions, ...
Chronic Traumatic Encephalopathy Cerebral Infarction Cerebral Ischemia Cerebral Stroke Cerebral Hemorrhage Parkinson Multi- ... Cerebral Hemorrhage. CADASIL. Chronic Traumatic Encephalopathy. Hypotension, Orthostatic. Cerebrovascular Disorders. Central ... Cerebral Vascular Accident. Stroke. Traumatic Brain Injury. Multiple Sclerosis. Parkinsons Disease. Neuropathy. ... Hemorrhage. Ischemia. Peripheral Nervous System Diseases. Brain Injuries, Traumatic. Atrophy. Motor Neuron Disease. Brain ...
... for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). METHODS: Experimental SAH was ... 8584085 - Traumatic occlusion of the anterior cerebral artery--case report.. 20362505 - Coarctation of the aorta presenting as ... Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in ... 17185885 - Pituitary apoplexy manifesting as diffuse subarachnoid hemorrhage.. 16613315 - Postprocedural monitoring of cerebral ...
Cerebral edema is commonly seen in a variety of brain injuries including ischemic stroke, subarachnoid hemorrhage, traumatic ... Cerebral Edema Cerebral edema is present with many common cerebral pathologies and risk factors for development of cerebral ... intracerebral hemorrhage, cerebral neoplasm. Clinical researches have recommended ICP and cerebral perfusion pressure (CPP) ... In traumatic brain injuries, cerebral edema occurred in greater than 60% of those with mass lesions, and in 15% of those with ...
Middle Cerebral Artery , Neck , Rupture , Subarachnoid Hemorrhage , Subarachnoid Hemorrhage, Traumatic , Vascular System ... Traumatic Rupture of the Middle Cerebral Artery Followed by Acute Basal Subarachnoid Hemorrhage: Tailored Approach in Forensic ... Middle Cerebral Artery / Subarachnoid Hemorrhage, Traumatic Clinical aspect: Diagnosis / Etiology Language: English Journal: ... Traumatic Rupture of the Middle Cerebral Artery Followed by Acute Basal Subarachnoid Hemor ...
A subarachnoid hemorrhage most often occurs as the result of significant head trauma and is usually seen in the setting of ... Subarachnoid hemorrhage, bleeding into the space between the two innermost protective coverings surrounding the brain, the pia ... of the hemorrhages are the result of a ruptured cerebral aneurysm. Other causes of spontaneous subarachnoid hemorrhage include ... Traumatic subarachnoid hemorrhage is most often the result of a significant mechanical force applied to the skull. Accompanying ...
Intracerebral hemorrhage (ICH) accounts for 10%-30% of all types of stroke. Bleeding within the brain parenchyma causes gray ... Intracerebral hemorrhage(ICH) accounts for 10-30% of all types of stroke. Bleeding within the brain parenchyma causes gray ... Cerebral microdialysis in traumatic brain injury and subarachnoid hemorrhage: state of the art. Neurocrit. Care 21, 152-162. ... Cerebral microdialysis (CMD) is a well-established laboratory tool that provides an on-line analysis of the brain biochemistry ...
... cerebral hemorrhage; vertebral injury; cardiac infarction; cerebral apoplexy including subarachnoid hemorrhage; central and ... traumatic neurological diseases including head injury, cerebral contusion and spinal cord injury; inflammatory diseases; and ... cerebral hemorrhage; vertebral injury; cardiac infarction; cerebral apoplexy including subarachnoid hemorrhage; central and ... In particular, its effectiveness on injuries in nervous system due to cerebral infarction, cerebral hemorrhage or vertebral ...
In traumatic brain injury, episodes of low cerebral oxygenation are also associated with poor outcome.6,7 Brain tissue oxygen ... Cerebral blood flow augmentation in patients with severe subarachnoid haemorrhage. Acta Neurochir Suppl. 2005; 95: 123-127. ... Cerebral oxygen metabolism after aneurysmal subarachnoid haemorrhage. J Cereb Blood Flow Metab. 1991; 11: 837-844. ... Effect of hypertonic saline on cerebral blood flow in poor grade patients with subarachnoid haemorrhage. Stroke. 2003; 34: 1389 ...
Synonyms and Keywords: Intracranial bleed; ICH; intracranial haemorrhage; cerebral bleed; cerebral hemorrhage; intracerebral ... Traumatic brain injury. Intracranial hemorrhage · Intraparenchymal hemorrhage · Subdural hematoma · Epidural hematoma · ... Subarachnoid hemorrhage · Intraventricular hemorrhage · Brain herniation · Cerebral contusion · Cerebral laceration · ... Intra-Axial Hemorrhage , Extra-Axial Hemorrhage. Pathophysiology. Causes. Differentiating Intracranial Hemorrhage from other ...
Palamarchuk, Dmitriy; May 11, 1931, Evansville; non-traumatic cerebral hemorrhage, Dec. 25 ... 17, 1929, Evansville; subdural hemorrhage, blunt force trauma to the head, fall impacting head on ground, Dec. 13 ... Rudolph, Bernice Rose; March 24, 1925, Evansville; intracerebral hemorrhage, Dec. 13. Rushing, Charles Douglas; Nov. 7, 1944, ... 2, 1926, Evansville; respiratory failure, cerebral vascular accident, atherosclerotic cardiovascular disease, hypertension, Dec ...
traumatic brain injury. lactate. brain metabolism. cerebral microdialysis. subarachnoid hemorrhage. transcranial doppler. ... In patients with severe Traumatic Brain Injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) monitored with cerebral ... Brain Injuries, Traumatic. Brain Diseases. Wounds and Injuries. Hemorrhage. Subarachnoid Hemorrhage. Central Nervous System ... Lactate Therapy After Traumatic Brain Injury (LS_TCC). The safety and scientific validity of this study is the responsibility ...
... patients with cerebral vasospasm stimulates vasoconstriction and oxygen consumption in the porcine carotid artery in vitro. ... Previous Document: Computed tomography of the brain in predicting outcome of traumatic intracranial haemorrhage in Mala.... ... 11527524 - Subarachnoid hemorrhage.. 2781234 - The prognostic value of ventricular rupture in cerebral hemorrhage.. 3202714 - ... BACKGROUND: The cerebrospinal fluid (CSF) from subarachnoid haemorrhage (SAH) patients with cerebral vasospasm stimulates ...
Intraparenchymatous brainstem hemorrhage.-Perimesencephalic subarachnoid hemorrhage and cerebral superficial siderosis.- ... Traumatic Brainstem Lesions.-Degenerative brainstem disorders.-Abnormalities of brainstem development.-Metabolic brainstem ...
Cerebral edema.. Hydrocephalous.. Trauma and traumatic vascular lesions (epi and sub-dural hematoma) ... intracranial haemorrhages; primitive intraparenchymal haemorrhages; saccular aneurysms; sub-arachnoid haemorrhages; vascular ... Pathology and pathogenesis of: thromboembolism, pulmonary infarction and hemorrhage. Pulmonary hypertension (primary and ... Vascular lesions. Morphological features and pathogenesis of: hypoxic-ischemic encephalopathy; cerebral infarct, ...
The purposes of this article are to discuss a variety of liver masses that can present with hemorrhage, including their ... Cerebral Hemorrhage, Traumatic. Bleeding into one or both CEREBRAL HEMISPHERES due to TRAUMA. Hemorrhage may involve any part ... Traumatic and atraumatic fractures are entities with distinct but often overlapping clinical manifestations, imaging findings, ... Pathologic features include cerebral prion protein amyloidosis, and spongiform or neurofibrillary degeneration. (From Brain ...
  • Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. (semanticscholar.org)
  • Traumatic Acute Subdural Hematoma in Elderly Patient. (lookfordiagnosis.com)
  • The post-mortem computed tomography (CT) with angiography revealed acute basal subarachnoid hemorrhage with rupture of the left middle cerebral artery. (bvsalud.org)
  • and (iii) outcome: acute traumatic lesion on non-contrast head CT ≤24 h post-injury. (frontiersin.org)
  • No well-designed diagnostic studies with specific GFAP cutoff values predictive of acute traumatic intracranial lesions have been published. (frontiersin.org)
  • However, blood-based GFAP holds promise as a means of screening for acute traumatic CT-positive lesion following head trauma. (frontiersin.org)
  • Background: Although glucose is essential to cerebral function, abundant experimental and clinical evidence demonstrates that endogenously released lactate, rather than glucose, is the preferential energy substrate for the brain in conditions of stress and acute injury. (clinicaltrials.gov)
  • Hypothesis: The investigators test the hypothesis that lactate therapy, administered during the acute phase of TBI or SAH, might exercise neuroprotective actions by restoring brain energetics and improving brain tissue PO2 and cerebral blood flow (CBF). (clinicaltrials.gov)
  • Based on manual light assessment of the pupils, it was determined that the patient had suffered irreversible demise from an acute traumatic subdural hematoma. (wikipedia.org)
  • The extent and severity of the symptoms of cerebral edema depend on the exact etiology but are generally related to an acute increase of the pressure within the skull. (wikipedia.org)
  • This includes all processes that occur in the (sub)acute setting, including the initial hemorrhage and subsequent in-hospital complications (such as rebleeding, delayed cerebral ischemia, hydrocephalus, and infections), and the relationship of these processes with micro- and macrostructural brain injury, disability, and cognitive impairment. (umcutrecht.nl)
  • The investigators propose to initiate the evaluation of levetiracetam in prevention of post-traumatic epilepsy by determining the safety, tolerability, pharmacokinetics and feasibility of acute and chronic administration of levetiracetam to individuals with head injury with a high risk for developing post-traumatic epilepsy. (clinicaltrials.gov)
  • 66 subjects with acute head injury with a high risk for developing post-traumatic epilepsy will receive levetiracetam 55 mg/kg/day in a b.i.d. schedule. (clinicaltrials.gov)
  • 60 subjects with acute head injury with a high risk for developing post-traumatic epilepsy enrolled 8-24 hours after injury will not receive levetiracetam. (clinicaltrials.gov)
  • The 66 subjects with acute head injury with a high risk for developing post-traumatic epilepsy that received levetiracetam 55 mg/kg/day in a b.i.d. were monitored for adverse events through the 30 day treatment period. (clinicaltrials.gov)
  • My main research interests are biomarkers in diagnostics of acute phase, treatment effects, and outcome of traumatic brain injury, biomaterials in cranial reconstruction and neuro-oncology. (utu.fi)
  • A traumatic brain injury is an acute trauma, such as from a fall or vehicle accident. (medicalnewstoday.com)
  • Most importantly it describes how neuroimaging of children with intracerebral hemorrhage should be tailored to specific situations and clinical contexts and recommends specific imaging protocols for acute and repeat imaging. (mdpi.com)
  • Few cerebral venous sinus thrombosis (CVST) may appear after acute SAH with similar clinical manifestations as aneurysm bleeding, raising difficulties for SAH diagnosis in clinics. (alliedacademies.org)
  • Authors: Khey KMW, Huard A, Mahmoud SH Abstract Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular emergency resulting from the rupture of a brain aneurysm. (medworm.com)
  • Provides inpatient and outpatient cerebral blood flow studies for patients with acute stroke, subarachnoid hemorrhage, arteriovenous malformations, or traumatic brain injury: 1. (uclahealth.org)
  • Severe hypernatremia (as induced by use of hypertonic saline for traumatic brain injury) can result in acute kidney injury. (oncologynurseadvisor.com)
  • Left subdural collection of mixed density in keeping with acute on subacute subdural haemorrhage. (radiopaedia.org)
  • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. (semanticscholar.org)
  • Our findings indicate that elevated brain lactate more often occurs in the absence of brain hypoxia /ischemia and is mainly the consequence of increased cerebral glycolysis, i.e. it occurs in association with high extracellular pyruvate. (clinicaltrials.gov)
  • A study published in the Journal of Neurosurgery found that the NPi may signal an early warning of potential delayed cerebral ischemia and enable preemptive escalation of care. (wikipedia.org)
  • The incidence of this disorder should be considered in terms of its potential causes and is present in most cases of traumatic brain injury, central nervous system tumors, brain ischemia, and intracerebral hemorrhage. (wikipedia.org)
  • Younger age Higher severity of symptoms on the National Institutes of Health Stroke Scale Signs of current ischemia on clinical exam Decreased level of consciousness Hyper dense artery sign and larger affected area on CT imaging Higher blood glucose Cerebral edema has been traditional classified into two major sub-types: cytotoxic and vasogenic cerebral edema. (wikipedia.org)
  • During cerebral ischemia for example, the blood-brain barrier remains intact but decreased blood flow and glucose supply leads to a disruption in cellular metabolism and creation of energy sources, such as adenosine triphosphate (ATP). (wikipedia.org)
  • After his return to the Netherlands, he worked as a postdoc at the Laboratory of Experimental Vascular Medicine at the Academic Medical Center to study the role of microthrombosis in the pathogenesis of delayed cerebral ischemia after subarachnoid hemorrhage in a mouse model. (umcutrecht.nl)
  • 8: Cremers CH, van der Schaaf IC, Wensink E, Greving JP, Rinkel GJ, Velthuis BK, Vergouwen MD . CT perfusion and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. (umcutrecht.nl)
  • Background and Purpose- Delayed cerebral ischemia and infarction due to reduced CBF remains the leading cause of poor outcome after aneurysmal subarachnoid hemorrhage. (ahajournals.org)
  • Poor outcome after aneurysmal subarachnoid hemorrhage (SAH) is associated with low cerebral blood flow (CBF), ischemia, and stroke. (ahajournals.org)
  • Those who survive the initial bleed are often afflicted with severe disabilities thought to result from delayed cerebral ischemia (DCI). (medworm.com)
  • Cerebral ischemia is the most common cause of stroke, which is a leading cause of permanent disability in adults worldwide 1,2 It occurs when blood vessels serving the brain become blocked or burst depriving it of sufficient oxygen and nutrients. (bruker.com)
  • Despite advances in the understanding of the pathophysiology of cerebral ischemia, there are few therapeutic options 2 . (bruker.com)
  • Although several different mechanisms are involved in the pathogenesis of cerebral ischemia, the resultant inflammation of brain tissue is believed to be a key factor in determining the extent of irreversible brain damage and associated disability 3 . (bruker.com)
  • Increases in the levels of inflammatory markers have been found to correlate with poor outcome after cerebral ischemia. (bruker.com)
  • The molecular basis of the inflammatory response to cerebral ischemia is poorly understood, but a role of nicotinic acetylcholine receptors (nAChRs) has been indicated 4 . (bruker.com)
  • Further elucidation of the function of these receptors may thus help reduce cerebral inflammation and improve outcomes in patients with cerebral ischemia and brain diseases. (bruker.com)
  • Although such studies have highlighted the role of α7 nAChRs in brain disorders, the role of nAChRs in the neuroinflammatory response to cerebral ischemia had not been determined. (bruker.com)
  • To rectify this gap in the understanding of nAChRs involvement in cerebral ischemia, changes in the expression of the α7 receptor were studied in a rat model after inducing cerebral ischemia in the brain by a 90-minute intraluminal occlusion of the middle cerebral artery 8 . (bruker.com)
  • Rats with cerebral ischemia were treated with the α7 nAChRs agonist PHA 568487 or control and the effects visualized by in vivo PET imaging with [ 11 C]NS14492 as the radiotracer. (bruker.com)
  • The role of α7 receptors in the neuroinflammatory response to cerebral ischemia was supported by the decrease of [ 18 F]DPA-714 binding in ischemic rats treated with PHA 568487. (bruker.com)
  • It is hoped that the new information obtained in this study supporting the involvement of α7 nAChRs in the development of neuroinflammation after cerebral ischemia may facilitate the development of novel strategies to reduce disability after ischemic stroke and treatments to reduce the burden of other neurological diseases. (bruker.com)
  • Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. (semanticscholar.org)
  • Non-traumatic intracerebral haemorrhage is a spontaneous bleeding into the brain tissue. (doctorbhatia.com)
  • Can Getting Excited Right Before Cause An Cerebral Hemorrhage (Aneurysm) Brain? (lookfordiagnosis.com)
  • When a patient has a cerebral aneurysm , can lumber puncture cause coma? (medhelp.org)
  • Some authorities prefer to classify traumatic subarachnoid hemorrhages as a separate disorder from those that occur spontaneously as the result of a ruptured aneurysm or other internal pathology. (britannica.com)
  • In these cases, approximately 85% of the hemorrhages are the result of a ruptured cerebral aneurysm . (britannica.com)
  • It includes research on postoperative cognitive dysfunctions, the effect of anesthetics on the growing brain, the new theories for the development of cerebral aneurysm and cerebral vasospasm, and many more. (novapublishers.com)
  • A hemorrhage caused by a burst cerebral aneurysm requires the clipping of the artery through a surgical procedure where part of the skull is removed. (medicalnewstoday.com)
  • Caution is required when initiating triple-H therapy as potential complications include cardiopulmonary failure, exacerbation of cerebral edema, renal failure, hyponatremia, sepsis, and a theoretical risk of untreated aneurysm rupture [ 6 , 7 ]. (hindawi.com)
  • Most nontraumatic subarachnoid hemorrhage (SAH) is resulted from ruptured aneurysm. (alliedacademies.org)
  • The weakened arterial walls of an aneurysm are always in danger of sudden rupture, with resulting hemorrhage and death. (thefreedictionary.com)
  • The leading cause of non-traumatic subarachnoid hemorrhage is rupture of an intracranial aneurysm. (nih.gov)
  • Head CT scanning can also demonstrate intraparenchymal hematomas, hydrocephalus and cerebral edema and can help predict the site of aneurysm rupture. (nih.gov)
  • Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage. (elsevier.com)
  • Cerebral autoregulation after aneurysmal subarachnoid haemorrhage. (utu.fi)
  • ICH is more likely to result in death or major disability than ischaemic stroke or subarachnoid haemorrhage. (medworm.com)
  • In patients with severe Traumatic Brain Injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) monitored with cerebral microdialysis and brain tissue oxygen (PbtO2), our preliminary data show that increased brain extracellular lactate is frequently observed. (clinicaltrials.gov)
  • In 2011 he accepted a position as a staff neurologist at the UMC Utrecht and joined Prof. Gabriel Rinkel's research group on aneurysmal subarachnoid hemorrhage. (umcutrecht.nl)
  • His research focuses on unruptured intracranial aneurysms, diagnosis of (aneurysmal) subarachnoid hemorrhage, and brain injury after subarachnoid hemorrhage. (umcutrecht.nl)
  • Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study. (umcutrecht.nl)
  • This collection of papers represents a cross-section of the enormous progress that has been made towards a thorough understanding and effective treatment of neurovascular events following aneurysmal subarachnoid hemorrhage, including cerebral vasospasm. (worldcat.org)
  • Identifying Patient Report Outcomes Relevant to Aneurysmal Subarachnoid Hemorrhage Follow-Up / Stuart Ross, Deepti Bhargava, Yahia Al-Tamimi, Tony Goddard and Alan Tennant, et al. (worldcat.org)
  • Cerebral vasospasm is a major source of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). (hindawi.com)
  • Aneurysmal subarachnoid hemorrhage (aSAH) occurs in approximately 30,000 patients in the United States each year [ 1 ]. (hindawi.com)
  • The pathogenesis of such bleeds is incompletely understood, but may relate to localised intra-vascular coagulation following trauma, localised infarction and necrosis, subsequent fibrinolysis and gradual haemorrhage formation. (forensicmed.co.uk)
  • Cerebral complications of myocardial infarction. (unibo.it)
  • 3 Loss of autoregulation, vasospasm, and reduced CBF combine to cause cerebral hypoxia, metabolic abnormalities, raised intracranial pressure (ICP), and subsequent cerebral ischemic infarction. (ahajournals.org)
  • The personal identification number assigned to all individuals allowed retrieval of diagnoses of traumatic brain injury, cerebral ischemic infarction, and intracerebral hemorrhage from the National Patient Discharge Register. (neuroskills.com)
  • Subarachnoid hemorrhage (SAH) has been shown to affect cerebral volume and perfusion, possibly by induction of inflammation and vasospasm. (uu.nl)
  • Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys. (biomedsearch.com)
  • OBJECTIVE: The goal of this work was to investigate the efficacy of a calcitonin gene-related peptide (CGRP) slow-release tablet (CGRP tablet) for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). (biomedsearch.com)
  • RESULTS: In the SAH and placebo groups, cerebral vasospasm developed on Day 7 (54.8% of the pre-SAH value at the internal carotid artery, 62.3% at the middle cerebral artery, 51.3% at the anterior cerebral artery, and 56.1% as an average of the three arteries). (biomedsearch.com)
  • The CGRP concentration was positive only on Day 7 for the CGRP group (6.5 nmol/L). CONCLUSION: The CGRP tablet prevented cerebral vasospasm after SAH and may have significant potential for the treatment of patients with SAH. (biomedsearch.com)
  • Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. (semanticscholar.org)
  • The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held in Cincinnati, Ohio, USA, in July 2011. (worldcat.org)
  • The authors provide an updated review of the literature for previous and recent clinical trials evaluating medical treatments in patients with cerebral vasospasm secondary to aSAH. (hindawi.com)
  • Currently, the strongest evidence supports use of prophylactic oral nimodipine and initiation of triple-H therapy for patients in cerebral vasospasm. (hindawi.com)
  • Additionally, future investigational efforts will need to resolve discrepant definitions and outcome measures for cerebral vasospasm in order to permit adequate study comparisons. (hindawi.com)
  • Cerebral vasospasm is estimated to occur in up to 70% of all aSAH patients and remains a major cause of morbidity and mortality [ 2 ]. (hindawi.com)
  • In this report, we review the literature and provide a concise, updated summary of recent clinical trials and current medical treatments evaluated in patients with cerebral vasospasm secondary to aSAH. (hindawi.com)
  • CT examination confirmed all were with simple cerebral injury: 7 cases with cerebral laceration, 17 with cerebral laceration combined with diffuse axonal injury, and 4 with epidural hematoma. (alliedacademies.org)
  • 1. Epidural hemorrhage: Between the skull and the outer (dura) covering. (iahp.org)
  • The other category of intracranial hemorrhage is extra-axial hemorrhage, such as epidural, subdural, and subarachnoid hematomas, which all occur within the skull but outside of the brain tissue. (doctorbhatia.com)
  • Other causes of spontaneous subarachnoid hemorrhage include arteriovenous malformations, anticoagulation therapy, and the use of certain illicit drugs such as cocaine . (britannica.com)
  • These include: Carotid artery disease, cerebral aneurysms, arteriovenous malformations (AVMs), cavernous malformations, subarachnoid hemorrhage, cerebral revascularization, surgical treatment and prevention of stroke, and both benign and malignant lesions in the skull base. (mcw.edu)
  • Subsequent sections address the critical care of a wide range of cerebrovascular diseases: ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, arteriovenous malformations, cerebral venous thrombosis and traumatic injury. (platekompaniet.no)
  • Focal (localized) or diffuse edema (swelling) of the brain that frequently accompanies traumatic brain injuries. (iahp.org)
  • Edema with cerebral contusions, hemorrhages, or brain tumors is often focal (localized to one area of the brain) or may be diffuse. (iahp.org)
  • Cerebral edema following a TBI usually lasts from 3-10 days. (iahp.org)
  • Automated assessment of the pupillary light reflex has emerged as an objective means of measuring pupillary reactivity across a range of neurological diseases, including stroke, traumatic brain injury and edema, tumoral herniation syndromes, and sports or war injuries. (wikipedia.org)
  • A study published in Neurocritical Care found that automated pupillometry is more reliable than standard clinical assessments in detecting and tracking subtle changes in cerebral edema and pupillary reactivity during osmotic therapy. (wikipedia.org)
  • Cerebral edema is excess accumulation of fluid (edema) in the intracellular or extracellular spaces of the brain. (wikipedia.org)
  • The treatment of cerebral edema depends on the cause and includes monitoring of the person's airway and intracranial pressure, proper positioning, controlled hyperventilation, medications, fluid management, steroids. (wikipedia.org)
  • Extensive cerebral edema can also be treated surgically with a decompressive craniectomy. (wikipedia.org)
  • Cerebral edema is a major cause of brain damage and contributes significantly to the mortality of ischemic strokes and traumatic brain injuries. (wikipedia.org)
  • As cerebral edema is present with many common cerebral pathologies, the epidemiology of the disease is not easily defined. (wikipedia.org)
  • As the skull is a fixed and inelastic space, the accumulation of cerebral edema can displace and compress vital brain tissue, cerebral spinal fluid, and blood vessels, according to the Monro-Kellie doctrine. (wikipedia.org)
  • The following were reliable predictors for development of early cerebral edema in ischemic strokes. (wikipedia.org)
  • This simple classification helps guide medical decision making and treatment of patients affected with cerebral edema. (wikipedia.org)
  • Dr. Sheth's special interests include cerebral edema, traumatic brain injury, intracerebral hemorrhaging, and ischemic stroke. (nottingham.ac.uk)
  • The lack of oxygen can lead to brain swelling, referred to as cerebral edema . (medicalnewstoday.com)
  • Cerebral edema is when fluid builds up around the brain, causing an increase in pressure known as intracranial pressure. (medicalnewstoday.com)
  • Cerebral edema can restrict the supply of blood to the brain. (medicalnewstoday.com)
  • Cerebral edema can cause irreversible damage and, in some cases, be fatal. (medicalnewstoday.com)
  • Cerebral edema can also occur above altitudes of around 4,000 meters . (medicalnewstoday.com)
  • Diagnosing cerebral edema can be challenging, as there are many potential causes and the symptoms may vary considerably. (medicalnewstoday.com)
  • It should be corrected slowly over 48 hours to prevent development of cerebral edema. (oncologynurseadvisor.com)
  • A CT brain scan may be needed for patients with cerebral edema or brain injury. (oncologynurseadvisor.com)
  • The XIII International Symposium on Brain Edema intracerebral hemorrhage, including the primary event and Tissue Injury was held June 1-3, 2005, in Ann Ar- and the secondary injury that follows, prompted a o- bor, Michigan, USA. (springer.com)
  • The conference sented at the symposium as well as papers that were was held immediately after the Brain Edema Sym- presented at a satellite Intracerebral Hemorrhage Con- sium. (springer.com)
  • In keeping with the outstand- sium stayed an extra day to learn about the latest - ing XII Symposium held in Hakone, Japan in 2002, we velopments in intracerebral hemorrhage research, chose to include brain tissue injury as well as brain including ongoing clinical trials and basic research - edema as the subject matter for this meeting. (springer.com)
  • Brain vestigation focusing primarily on the secondary events edema, in many respects, is a marker of underlying which develop after the hemorrhage. (springer.com)
  • Traumatic brain edema in diffuse and focal injury: cellular or vasogenic? (springer.com)
  • BACKGROUND Intracerebral hemorrhage is the least treatable form of stroke. (semanticscholar.org)
  • The most common initial symptom of ICA dissection is unilateral neck or head pain followed by cerebral ischaemic symptoms like transient ischaemic attacks and stroke. (ispub.com)
  • Intracerebral hemorrhage can be caused by brain trauma, or it can occur spontaneously in hemorrhagic stroke. (doctorbhatia.com)
  • The rates of symptomatic hemorrhage in patients from the Safe Implementation of Thrombolysis in Stroke-Monitoring Study 3 and ECASS III 2 who received alteplase were 2.4% and 1.7%, respectively. (ajnr.org)
  • On histologic examination, a microscopic focal rupture was identified at the proximal portion of the middle cerebral artery, and possibility of arteriopathy was considered. (bvsalud.org)
  • A series of angiographic analyses were performed, before SAH and on Days 7 and 14, to examine changes in the diameters of the ipsilateral internal carotid artery, middle cerebral artery, and anterior cerebral artery. (biomedsearch.com)
  • Methods- Continuous monitoring of arterial blood pressure, intracranial pressure, cerebral perfusion pressure, brain tissue oxygen, carbon dioxide, pH, and middle cerebral artery flow velocity was performed in 44 patients. (ahajournals.org)
  • Mervyn Vergouwen is the president-elect of the 15th International Conference on SubArachnoid Hemorrhage (ISAH) 2019 and co-PI of the Prospective Randomized Open-label Trial to Evaluate risk faCTor management in patients with Unruptured intracranial aneurysms (PROTECT-U). (umcutrecht.nl)
  • Cerebral aneurysms rarely cause intraparenchymal hemorrhage, but are the most common cause of pure subarachnoid hemorrhage, even in children. (mdpi.com)
  • 5. Intraventricular hemorrhage: Within the fluid-filled cavities of the brain. (iahp.org)
  • intraparenchymal hemorrhage and intraventricular hemorrhages. (doctorbhatia.com)
  • Each kind of cerebral hemorrhage has distinctive clinical characteristics. (thefreedictionary.com)
  • The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. (semanticscholar.org)
  • Clinics need a rapid, efficient and strong specificity detection method to predict blood coagulation changes of patients with traumatic hemorrhage and to guide clinical treatment [ 3 ]. (alliedacademies.org)
  • This study is to analyse predictive function of TEG on blood coagulation changes in patients with cerebral traumatic hemorrhage, which can provide practical basis for clinical guidance. (alliedacademies.org)
  • Traumatic and atraumatic fractures are entities with distinct but often overlapping clinical manifestations, imaging findings, and management protocols. (bioportfolio.com)
  • Guidelines for traumatic brain injury are undergoing constant revision with the incorporation of newly completed clinical studies and research. (medscape.com)
  • It is therefore a strong candidate for a clinical trial of epilepsy prevention following traumatic brain injury (TBI). (clinicaltrials.gov)
  • Cerebral venous sinus thrombosis (CVST) is a rare and distinct cerebrovascular disorder with highly variable clinical presentations [ 1 ]. (alliedacademies.org)
  • 3 ]. Hemorrhagic infarctions were evident in 40% patients under CT-scan and hemorrhagic transformation occasionally lead to intracerebral or subarachnoid hemorrhages (SAH) [ 4 - 6 ], however SAH is a rare clinical presentation. (alliedacademies.org)
  • I have over 15 years experience in Clinical Psychology with expertise in psychological and neuropsychological assessments (child, adolescent and adult), disability evaluation, Traumatic Brain Injury (TBI), Psychiatric/Cognitive injuries, Immigration Evaluations, Personality Testing, Malingering and Symptom Validity Assessments. (forensisgroup.com)
  • Dr. Sinson has performed extensive laboratory and clinical research in these disorders and in traumatic brain injury. (mcw.edu)
  • Secondary injuries mediated by oxidative stress lead to deterioration of neurological functions after intracerebral hemorrhage (ICH). (frontiersin.org)
  • Furthermore, traumatic brain injuries and diseases that are impacting the brain health such as intra-cerebral hemorrhage, meningitis, and neurological damages among others are fostering the market growth to an extent. (medgadget.com)
  • Furthermore, factors such as the increasing prevalence of neurological diseases and disorders of the nervous system such as Schizophrenia, Parkinson's disease, and Cerebral Palsy alongside the changing lifestyle led by the growing urbanization and industrialization are fostering the market growth. (medgadget.com)
  • While the subarachnoid hemorrhage may not be directly responsible for neurological deficits such as numbness or weakness on one side of the body, these signs may be present as a result of concurrent injury to the brain. (britannica.com)
  • Traumatic brain injury (T.B.I.), is a very serious medical condition with a lot of health-related consequences, often leading to permanent neurological disabilities. (forensisgroup.com)
  • In addition, treatment with PHA 568487 significantly reduced cerebral infarct volumes and improved neurological outcomes compared with control. (bruker.com)
  • Rapid imaging allows early diagnosis and characterization of the localization and severity of the haemorrhage. (medworm.com)
  • This will facilitate prompt identification and treatment of a retained foreign body, preventing delay in diagnosis and subsequent sequelae, such as infection, hemorrhage, or death. (harvard.edu)
  • A very small proportion is due to cerebral venous sinus thrombosis. (doctorbhatia.com)
  • interventions A computed tomography scan may be performed to locate the lesion and to differentiate the hemorrhage from an embolus or thrombus, or cerebral angiography may be used for these purposes. (thefreedictionary.com)
  • Therefore, we suggest that post-mortem angiography can be an effective and adjunctive tool for a tailored approach in finding the vascular injury, and that histologic examination of both the intracranial and extracranial arteries be important to medicolegally ensure the death of traumatic basal subarachnoid hemorrhage and to examine presence of arteriopathy as a predisposing factor. (bvsalud.org)
  • Brain bleed Neurology Abrupt bleeding into cerebral tissue, which may be 2º to HTN, ASHD malformations or trauma. (thefreedictionary.com)
  • A 73 yr old women suffers a severe cerebral hemorrhage after minor trauma. (lookfordiagnosis.com)
  • a woman suffers a severe cerebral hemorrhage after minor trauma.blood work reveals that her blood clotting? (lookfordiagnosis.com)
  • 73 year old woman suffers sever cerebral hemorrhage after minor trauma? (lookfordiagnosis.com)
  • impact of SAH due to trauma on cerebral perfusion and brain volume. (uu.nl)
  • Intra-cerebral haemorrhages may be primary (i.e. occurring at the time of the trauma) or secondary, due to the effects of raised intra-cranial pressure and cerebral oedema. (forensicmed.co.uk)
  • Need an opinion on MRI of head trauma - probable cerebral haemorrhage. (medhelp.org)
  • 10 , 11 In some studies, MR imaging results were normal for athletes with head trauma, 7 , 9 whereas other studies demonstrated a variably increased prevalence of cerebral microhemorrhage (CMH), 4 , 5 nonspecific WM changes (NSWMCs), 11 or cavum septum pellucidum (CSP)/cavum septum pellucidum and vergae (CSPV). (ajnr.org)
  • However, the Brain Trauma Foundation recently published revised guidelines for severe traumatic brain injury, and their recommendations have been endorsed by neurosurgical professional organizations. (medscape.com)
  • A subarachnoid hemorrhage most often occurs as the result of significant head trauma and is usually seen in the setting of skull fractures or injuries to the brain itself. (britannica.com)
  • Clinically, the two types of subarachnoid hemorrhage may be difficult to distiguish in the absence of clear indication of trauma. (britannica.com)
  • When a subarachnoid hemorrhage is secondary to head trauma, there is typically a constellation of symptoms similar to that seen in all serious head injuries that includes confusion or loss of consciousness, memory loss, dizziness or unsteadiness, lack of coordination, nausea and/or vomiting , or sleepiness. (britannica.com)
  • Brain injuries caused by trauma are known as a traumatic brain injuries (TBIs) (Brain Injury Australia 2020). (ausmed.com.au)
  • Trauma is the most common cause of intracerebral hemorrhage (ICH) in children, and the distinction between traumatic versus spontaneous hemorrhage can be challenging. (mdpi.com)
  • With more than 20 years experience in neuropsychology, I have expertise in traumatic brain injury, prenatal injury, toxic encephalopathy, and emotional effects of trauma. (forensisgroup.com)
  • There is documentation in the scientific literature that intranasal delivery of BMSC allows the BMSC to follow the pathways of the trigeminal nerve, facilitating entry into the parenchyma and cerebral spinal fluid (CSF) for effects on the CNS. (clinicaltrials.gov)
  • hemorrhage into the substance of the cerebrum, usually in the region of the internal capsule by the rupture of the lenticulostriate artery. (thefreedictionary.com)
  • Most cerebral hemorrhages occur in the region of the basal ganglia and are caused by the rupture of a sclerotic artery as a result of hypertension. (thefreedictionary.com)
  • Does anyone know what this cerebral artery stuff is, & could i caught it from my b. (medhelp.org)
  • Post traumatic Carotid cavernous fistula (CCF) is a rare complication of moderate to severe head injury in which an abnormal communication develops between internal carotid artery (ICA) and the cavernous sinus. (thefreelibrary.com)
  • The long-course AChA has anastomoses with the lateral posterior choroidal artery, the posterior cerebral artery and the posterior communicating artery [ 10 , 11 ]. (medsci.org)
  • A temporary endovascular balloon catheter was then placed into the left cavernous internal carotid artery (ICA) as a precautionary measure to control bleeding in the event of intraoperative hemorrhage (Figure 2). (harvard.edu)
  • Factors affecting oral feeding with severe traumatic brain injury. (medscape.com)
  • Critical Care published a study examining the relationship between the NPi and invasive intracranial pressure (ICP) in 54 patients with severe traumatic brain injury (TBI). (wikipedia.org)
  • Paroxysmal sympathetic hyperactivity (PSH) results and aggravates in secondary brain injury, which seriously affects the prognosis of severe traumatic brain injury patients. (peerj.com)
  • Ninety post-operation (post-op) severe traumatic brain injury (sTBI) patients admitted from October 2014 to April 2016 were chosen to participate in this study. (peerj.com)
  • Studies suggested that the neutrophil-to-lymphocyte ratio (NLR) was associated with unfavorable outcomes in different diseases such as intracerebral hemorrhage, cardiovascular problem, cancer, and severe traumatic brain injury (sTBI). (springer.com)
  • Carney NA, Ghajar J. Guidelines for the management of severe traumatic brain injury. (springer.com)
  • It is of interest to clinicians who wish to apply state-of-the-art knowledge to their management of this devastating condition and to basic scientists wishing to expand their understanding of cerebrovascular and neural pathophysiology related to subarachnoid hemorrhage. (worldcat.org)
  • When a blow to the head is strong enough to cause temporary loss of consciousness (minutes to hours) and amnesia with tests showing bruises in the brain, the injury is called cerebral contusion. (iahp.org)
  • An autopsy shows there is no evidence of traumatic bone fractures, abnormality of the scalp or any cerebral hemorrhage or contusion in the brain. (craigdailypress.com)
  • Comment on: Early CSF and serum S 100B concentrations for outcome prediction in traumatic brain injury and subarachoid haemorrhage. (medscape.com)
  • Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury. (medscape.com)
  • Once identified, the subarachnoid hemorrhage requires immediate medical attention, and quick intervention is necessary to improve the chance of a positive outcome. (britannica.com)
  • In traumatic brain injury, episodes of low cerebral oxygenation are also associated with poor outcome. (ahajournals.org)
  • Objective: To evaluate the technical success, complications and outcome of endovascular management of post traumatic carotid cavernous fistula (CCF) in patients presenting at a tertiary care hospital in Karahci. (thefreelibrary.com)
  • Providing a value-added level of insight from the analysis team, several of the main symptoms and co-morbidities of Traumatic Brain Injury have been quantified and presented alongside the overall incidence figures. (prnewswire.co.uk)
  • At the time of the injury - in addition to losing consciousness and experiencing various other symptoms of brain injury - the individual might also experience post-traumatic amnesia (PTA) . (ausmed.com.au)
  • A brain hemorrhage can cause a variety of different symptoms. (medicalnewstoday.com)
  • [6] Intracerebral hemorrhages are often misdiagnosed as Subarachnoid hemorrhages due to the similarity in symptoms and signs. (doctorbhatia.com)
  • Most neurologic symptoms are attributable to cerebral overhydration. (oncologynurseadvisor.com)
  • Research and Markets has announced the addition of the 'Traumatic Brain Injury Forecast in 21 Major Markets 2016-2026' report to their offering. (prnewswire.co.uk)
  • 2. Subdural hemorrhage: Between the outer (dura) and middle (arachnoid) coverings. (iahp.org)
  • 3. Subarachnoid hemorrhage: Between the middle (arachnoid) and inner (pia) coverings. (iahp.org)
  • Subarachnoid hemorrhage , bleeding into the space between the two innermost protective coverings surrounding the brain , the pia mater and the arachnoid mater. (britannica.com)
  • The subarachnoid space is prone to blood collection whenever there is damage to any of the cerebral blood vessels that travel beneath the arachnoid layer, in close proximity to the surface of the brain. (britannica.com)
  • It usually presents with pain, cerebral ischaemia, Horner's syndrome or intracranial haemorrhage and rarely with pulsatile tinnitus. (ispub.com)
  • This case illustrates that other parts of intracerebral arteries (other than the vertebral arteries) can be the culprit of rupture in the case of traumatic basal subarachnoid hemorrhage, and the post-mortem angiographic findings can be helpful in targeting the site of vascular injury. (bvsalud.org)
  • Other patients with traumatic injury were regarded as B group, consisting of 8 male cases and 4 female cases (Age range: 23-62 y, mean ± sd=36.6 ± 5.6 y). (alliedacademies.org)
  • 10 In head-injured patients, mannitol has long been favored for lowering ICP while increasing cerebral perfusion pressure (CPP) and CBF. (ahajournals.org)
  • In this study, the investigators examined the effects of pHCT scans on intracranial pressure (ICP), cerebral perfusion pressure (CPP), and PbtO 2 in patients with severe brain injury. (thejns.org)
  • Skull fractures may be linear, undisplaced (like a crack in a dinner plate), stellate with multiple linear fracture lines diverging from a central point, depressed with a fragment of bone indenting or cutting into the brain, diastatic with a wide separation of the fracture margins, suggesting a massive underlying hemorrhage or severe diffuse swelling of the brain, egg shell with multiple fractures in different parts of the skull. (iahp.org)
  • 1 The diffuse nature of SAH and action of red cell breakdown products has widespread effects on the cerebral vasculature. (ahajournals.org)
  • Primary injuries to the brain include cerebral contusions, lacerations and diffuse axonal injury , which can then be followed by secondary injuries such as cerebral oedema, hypotension , hypoxia and electrolyte imbalances (Chua et al. (ausmed.com.au)
  • Non- recanalization was still in 1 patient who received craniotomy hematoma craniectomy because of secondary intracranial hemorrhage after intrasinus thrombolytic therapy. (alliedacademies.org)
  • The presence of a subarachnoid hemorrhage is usually confirmed with a computed tomography (CT) scan of the head. (britannica.com)
  • Computed tomography (CT) scanning of the head should be the first examination performed in any patient with suspected subarachnoid hemorrhage. (nih.gov)
  • Intraparenchymal hemorrhage can be recognized on CT scans because blood appears brighter than other tissue and is separated from the inner table of the skull by brain tissue. (doctorbhatia.com)
  • Such injuries include blows to the head, lack of oxygen from suffocation, smoke inhalation or near drowning, hemorrhages, brain tumors, infections and penetrating wounds. (iahp.org)
  • A subarachnoid hemorrhage is typically symptomatic, with headache and an alteration of consciousness being common. (britannica.com)
  • secondary hemorrhage that which follows an injury after a considerable lapse of time. (thefreedictionary.com)
  • SBI following primary impact (e.g., secondary hemorrhage insults) are important causes of damage to the brain [ 1 , 2 ]. (hindawi.com)
  • In the setting of a spontaneous subarachnoid hemorrhage, the hallmark symptom is known as the "thunderclap headache. (britannica.com)
  • Endovascular approach as primary treatment for traumatic carotid cavernous fistula: local experience from Pakistan. (thefreelibrary.com)
  • Conclusion: Endovascular approach is a safe and useful option for treatment of traumatic carotid cavernous fistula. (thefreelibrary.com)
  • This pilot study is the first step in evaluation of levetiracetam in prevention of post-traumatic epilepsy. (clinicaltrials.gov)
  • Methods: Descriptive case series of 26 patients of post traumatic CCF treated by endovascular techniques was carried out at Radiology and Neurosurgery departments of Aga Khan University hospital between January 2010 to March 2010. (thefreelibrary.com)
  • I specialize in providing evaluations of veterans with claimed disabilities, including post traumatic stress disorder and traumatic brain injury. (forensisgroup.com)
  • There can be intercranial or subdural haemorrhage, tearing and/or penetration of brain tissue by a foreign object. (ausmed.com.au)
  • Progression of parenchymal contusions in frontal and temporal lobes and of frontal subdural haemorrhage. (radiopaedia.org)
  • Case reports had identified haemorrhages predominantly occurring in the frontal and temporal lobes, but occasionally they were multiple, and located in the basal ganglia, parietal cortex and cerebellum. (forensicmed.co.uk)
  • Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. (semanticscholar.org)
  • Intra-cerebral haemorrhages may be superficial (in association with contusions) or deep-seated (usually within the basal ganglia). (forensicmed.co.uk)
  • Transcranial Doppler (TCD): Non-invasive assessment of blood flow velocity in the basal cerebral arteries. (uclahealth.org)
  • A generic term for haemorrhage within the cerebral parenchyma which, when superficial, is most commonly caused by contusions and, if deep, more often linked to hypertension and occurs in the putamen, thalamus, internal capsule, cerebellum or pons. (thefreedictionary.com)
  • When an intra-cerebral haemorrhage has been caused by natural disease (such as systemic hypertension, for example), the haemorrhage is usually single, and located in the deep grey matter (e.g. thalamus), pons or cerebellum. (forensicmed.co.uk)
  • [3] This kind of hemorrhage can also occur in the cortex or subcortical areas, usually in the frontal or temporal lobes when due to head injury, and sometimes in the cerebellum. (doctorbhatia.com)
  • A brain hemorrhage occurs when a blood vessel in the brain ruptures and leaks. (medicalnewstoday.com)
  • A traumatic brain injury occurs when a sudden, violent blow or jolt to the head results in brain damage. (medicalnewstoday.com)
  • hypertensive hemorrhage rarely occurs in children, and cerebral amyloid angiopathy is almost exclusively an adult disease [ 3 ]. (mdpi.com)
  • A cerebral hemorrhage (or intracerebral hemorrhage , ICH ), is a subtype of intracranial hemorrhage that occurs within the brain tissue itself. (doctorbhatia.com)
  • The risk of death from an intraparenchymal bleed in traumatic brain injury is especially high when the injury occurs in the brain stem. (doctorbhatia.com)
  • Treatment of head injury, including the reduction of cerebral oedema and the use of diuretics may also contribute to their formation. (forensicmed.co.uk)
  • Some resolution of previously documented haemorrhages, with surrounding cerebral oedema. (radiopaedia.org)