Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Bleeding or escape of blood from a vessel.
The arterial blood vessels supplying the CEREBRUM.
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
Bleeding within the SKULL that is caused by systemic HYPERTENSION, usually in association with INTRACRANIAL ARTERIOSCLEROSIS. Hypertensive hemorrhages are most frequent in the BASAL GANGLIA; CEREBELLUM; PONS; and THALAMUS; but may also involve the CEREBRAL CORTEX, subcortical white matter, and other brain structures.
The susceptibility of CAPILLARIES, under conditions of increased stress, to leakage.
Radiography of the vascular system of the brain after injection of a contrast medium.
A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.
Bleeding from the vessels of the retina.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
Bleeding into one or both CEREBRAL HEMISPHERES due to TRAUMA. Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. Depending on the severity of bleeding, clinical features may include SEIZURES; APHASIA; VISION DISORDERS; MOVEMENT DISORDERS; PARALYSIS; and COMA.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.
Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846)
A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Elements of limited time intervals, contributing to particular results or situations.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is the most frequently seen isolate of that group, has a proclivity for abscess formation, and is most often isolated from the blood, gastrointestinal, and urogenital tract.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Hemorrhage into the VITREOUS BODY.
Intraocular hemorrhage from the vessels of various tissues of the eye.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Disease having a short and relatively severe course.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.
Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
Veins draining the cerebrum.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Agents that prevent clotting.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Bleeding within the subcortical regions of cerebral hemispheres (BASAL GANGLIA). It is often associated with HYPERTENSION or ARTERIOVENOUS MALFORMATIONS. Clinical manifestations may include HEADACHE; DYSKINESIAS; and HEMIPARESIS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
An infant during the first month after birth.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The return of a sign, symptom, or disease after a remission.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Hemorrhage from the vessels of the choroid.
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.
Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS; INTERNAL CAPSULE; PUTAMEN; SEPTAL NUCLEI; GYRUS CINGULI; and surfaces of the FRONTAL LOBE and PARIETAL LOBE.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Intracranial bleeding into the PUTAMEN, a BASAL GANGLIA nucleus. This is associated with HYPERTENSION and lipohyalinosis of small blood vessels in the putamen. Clinical manifestations vary with the size of hemorrhage, but include HEMIPARESIS; HEADACHE; and alterations of consciousness.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Accumulation of blood in the SUBDURAL SPACE between the DURA MATER and the arachnoidal layer of the MENINGES. This condition primarily occurs over the surface of a CEREBRAL HEMISPHERE, but may develop in the spinal canal (HEMATOMA, SUBDURAL, SPINAL). Subdural hematoma can be classified as the acute or the chronic form, with immediate or delayed symptom onset, respectively. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.
Hemorrhage within the orbital cavity, posterior to the eyeball.
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
Radiography of the ventricular system of the brain after injection of air or other contrast medium directly into the cerebral ventricles. It is used also for x-ray computed tomography of the cerebral ventricles.
Dominance of one cerebral hemisphere over the other in cerebral functions.
Bleeding within the brain as a result of penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA. Traumatically induced hemorrhages may occur in any area of the brain, including the CEREBRUM; BRAIN STEM (see BRAIN STEM HEMORRHAGE, TRAUMATIC); and CEREBELLUM.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
A scale that assesses the response to stimuli in patients with craniocerebral injuries. The parameters are eye opening, motor response, and verbal response.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.

Intracranial arteriovenous malformations. Observations after experience with computerised tomography. (1/3145)

Thirty-six patients with angiographically confirmed intracranial arteriovenous malformations have had computerised tomographic scans performed as part of their investigation. This study demonstrates the incidence of haematoma formation after haemorrhage, the frequency of calcification not visible on plain radiographs, and describes the possible causes for a complicating hydrocephalus. Further information has been gained from the intravenous injection of sodium iothalamate (Conray 420), with comparison of the scans taken before and after the injection.  (+info)

Intracerebral hemorrhage in young people: analysis of risk factors, location, causes, and prognosis. (2/3145)

BACKGROUND AND PURPOSE: The frequency of intracerebral hemorrhages (ICHs) in people aged 31 years (odds ratio, 3.48), and those with ICH that resulted from arteriovenous malformations were aged <20 years (odds ratio, 2.80). The final outcome was considered favorable in 60%. CONCLUSIONS: ICHs in young people are mainly lobar in location and result from vascular malformation. Hypertension causes most cases in which the ICH is located in the basal ganglia. Mortality and morbidity in the acute phase are low and are related to hypertension as the cause of ICH.  (+info)

Increased platelet activation in the chronic phase after cerebral ischemia and intracerebral hemorrhage. (3/3145)

BACKGROUND AND PURPOSE: Enhanced thromboxane (TX) biosynthesis has previously been reported in the acute phase after ischemic stroke. We investigated whether enhanced urinary excretion of 11-dehydro-TXB2, a noninvasive index of platelet activation, was present in the chronic phase after a transient ischemic attack (TIA) or stroke, including intracerebral hemorrhage. METHODS: We obtained a single urinary sample from 92 patients between 3 and 9 months after onset of stroke or TIA. The urinary excretion of the major enzymatic metabolite of TXA2, 11-dehydro-TXB2, was measured by a previously validated radioimmunoassay. The excretion rates were compared with those of 20 control patients with nonvascular neurological diseases. RESULTS: Urinary 11-dehydro-TXB2 averaged 294+/-139, 413+/-419, and 557+/-432 pmol/mmol creatinine for patients with TIA, ischemic stroke, and intracerebral hemorrhage, respectively; the values were higher in all subgroups (P<0.01) than that in control patients (119+/-66 pmol/mmol). Increased 11-dehydro-TXB2 excretion was present in 59% of all patients, in 60% (P<0.001) of patients with TIA, in 56% (P<0.001) of patients with ischemic stroke, and in 73% (P<0.001) of patients with intracerebral hemorrhage. Atrial fibrillation, no aspirin use, and severity of symptoms at follow-up contributed independently to the level of 11-dehydro-TXB2 excretion in a multiple linear regression analysis. CONCLUSIONS: Platelet activation is often present in patients in the chronic phase after stroke, including those with intracerebral hemorrhage. Persistent platelet activation, which is associated with atrial fibrillation and poor stroke outcome, can be substantially suppressed by aspirin treatment.  (+info)

Intensive care management of stroke patients. (4/3145)

Two hundred eighty patients were admitted to an intensive care stroke unit over a one-year period. Subsequent investigation indicated that only 199 of these patients actually had cerebral ischemic or hemorrhagic lesions, 10 had other cerebrovascular lesions, and the remaining 71 patients had unrelated diseases, predominantly seizures. Detailed analysis of 103 stroke patients revealed an overall incidence of 59% hypertension, and 72% had hypertensive, ischemic or valvular heart disease. Fifty percent of the patients had various cardiac arrhythmias, some of which were responsible for the acute cerebrovascular lesion. Fourteen patients died during the acute phase, 11 from apparently irreversible cerebral selling, mainly due to cerebral hemorrhage. Secondary complications such as pneumonia, pulmonary embolism, pressure sores and urinary infection were almost nonexistent, but beneficial effects on the primary cerebral lesions were more difficult to demonstrate.  (+info)

A prospective study of cerebrovascular disease in Japanese rural communities, Akabane and Asahi. Part 1: evaluation of risk factors in the occurrence of cerebral hemorrhage and thrombosis. (5/3145)

An epidemiological study of cerebrovascular disease in Akabane and Asahi, Japan, was made. (These cities are located near Nagoy, Japan.) The study population included 4,737 men and women aged 40 to 79 at the time of entry into the study. There were 4,186 persons who were examined and, of these, 264 cases of cerebrovascular attacks were observed between 1964 and 1970. The incidence rate of stroke in those persons not responding to the survey was 15.9 times higher than in those persons examined according to person-year observation in Akabane. The risk factors for cerebral hemorrhage and thrombosis were evaluated by age-adjusted and sex-adjusted relative risks. The predisposing factors to cerebral hemorrhage appeared to be high blood pressure, high left R wave, ST depression, T abnormality, capillary fragility counts, previous medical history of stroke and albuminuria. For cerebral thrombosis, the predisposing factors appeared to be high blood pressure, ST depression and funduscopic sclerotic findings, and those factors assumed to be significant were glycosuria and smoking habits. Ocular funduscopic abnormality was the most prominent risk factor for cerebral thrombosis, while high blood pressure and ECG abnormalities were highly related to cerebral hemorrhage. It was suggested that those subjects with a relatively higher blood pressure may have a higher relative risk of cerebral hemorrhage than those with a lower (normal range) blood pressure. A previous or family history of stroke also appeared significantly related to cerebral hemorrhage.  (+info)

Primary non-traumatic intracranial hemorrhage. A municipal emergency hospital viewpoint. (6/3145)

The devastating natural history of 138 consecutive admissions for non-traumatic intracranial hemorrhage to a major emergency care municipal hospital is reviewed. Sixty-four percent of the patients had demonstrable intracranial hematomas while 36% had mainly subarachnoid hemorrhage. Hypertension was a related condition in 43% of the parenchymal hematoma patients, while proved aneurysms accounted for 74% of the subarachnoid hemorrhage patients. There was only a 14% survivorship for patients requiring emergent surgery. All operated hematoma patients survived delayed surgery with improved level of responsiveness. The overall mortality was 74% for intracranial hematoma patients and 58% for aneurysm-caused subarachnoid hemorrhage patients.  (+info)

Angiographical extravasation of contrast medium in hemorrhagic infarction. Case report. (7/3145)

Leakage of the contrast medium was noted on angiograms of a patient whose autopsied brain disclosed typical pathological findings of hemorrhagic infarction. The case was a 63-year old woman with mitral valve failure, who suddenly had loss of consciousness and right-sided hemiplegia. The left carotid angiography performed six hours after onset demonstrated middle cerebral arterial axis occlusion, and the second angiography performed three days after onset displayed recanalization of the initially occluded artery as well as extravasation of the contrast medium. Fourteen days after onset the patient died and an autopsy was performed. The brain demonstrated perivascular punctate hemorrhages in the area supplied by the middle cerebral artery, and neither hematoma nor microaneurysm was disclosed pathologically. A short discussion is given on the possible relationship between recanalization and hemorrhagic infarction. The clinical assessment of hemorrhagic infarction has not been established successfully.  (+info)

Pure apraxic agraphia with abnormal writing stroke sequences: report of a Japanese patient with a left superior parietal haemorrhage. (8/3145)

A 67 year old Japanese male patient had pure agraphia after a haemorrhage in the left superior parietal lobule. He developed difficulty in letter formation but showed no linguistic errors, consistent with the criteria of apraxic agraphia. He manifested a selective disorder of sequencing writing strokes, although he was able to orally state the correct sequences. The patient's complete recovery after 1 month, without new learning, showed that he had manifested a selective disorder of writing stroke sequences. These findings indicate that the final stage of the execution of writing according to acquired sequential memory shown as a stroke sequence can be selectively disturbed, and should be considered to be distinct from the ability of character imagery and the knowledge of the writing stroke sequence itself. This case also indicates that the left superior parietal lobule plays an important part in the execution of writing.  (+info)

Abstract Background Neuroendocrine changes have been reported after ischemic stroke, subarachnoid hemorrhage, and brain trauma. As there are no corresponding data in patients with intracerebral hemorrhage (ICH) we analyzed various neuroendocrine parameters to investigate possible alterations in hormone profiles of patients with ICH.. Methods Twenty patients with ICH were prospectively enrolled in the study. Patients were a priori parted into two groups: Ten non-ventilated patients treated on the stroke-unit (hemorrhage volumes ,20 ml, small ICH), and 10 ventilated patients treated on the neurocritical care unit (hematoma volumes ,20 ml with possible additional ventricular involvement (large ICH). Neuroendocrine parameters were compared between both groups referring to reference values. The following parameters were obtained over a period of 9 days in 20 patients with spontaneous supratentorial ICH: thyrotropin, free thiiodothyronine and thyroxine, human growth hormone, insulin-like growth ...
TY - JOUR. T1 - Predictors of early deterioration and mortality in black americans with spontaneous intracerebral hemorrhage. AU - Qureshi, Adnan I.. AU - Safdar, Kamran. AU - Weil, E. Jennifer. AU - Barch, Carol. AU - Bliwise, Donald L.. AU - Colohan, Austin R.. AU - Mackay, Bruce. AU - Frankel, Michael R.. PY - 1995/10. Y1 - 1995/10. N2 - Black Americans with spontaneous intracerebral hemorrhage (SICH) may have unique clinical characteristics that affect outcome. The aim of this study was to determine the prognostic value of clinical characteristics and initial CT scan for outcome in black Americans with SICH. Methods Clinical and demographic data were extracted from the charts of 182 consecutive black Americans admitted for SICH diagnosed by clinical criteria and initial CT scan. Hemorrhage volumes were calculated from admission CT scans by a computerized method. Univariate and multiple logistic regression analyses were performed to determine independent predictors of early deterioration ...
Background: Current American Heart Association guidelines for targeted blood pressure management in spontaneous intracerebral hemorrhage (ICH), published in 2010, suggest a target mean arterial pressure of less than 110 or a blood pressure of less than 160/90 in patients without elevated intracranial pressure. These guidelines acknowledge that these recommendations have been based on incomplete efficacy evidence. A lower level recommendation was given for reducing target blood pressure to a systolic of 140, based on the INTERACT trial published in 2008. The INTERACT2 trial, published in May 2013, has been interpreted to establish the safety of rapid blood pressure lowering to 140 systolic.. Purpose: To determine the current level of adoption by stroke centers of lower targets for blood pressure in patients with spontaneous intracerebral hemorrhage, and whether these targets have changed in 2013.. Methods: We developed a web-based survey that was distributed via email and professional groups to ...
Spontaneous intracerebral haemorrhage: a clinical review.: This article provides a clinical overview of spontaneous intracerebral haemorrhage, focusing on clini
TY - JOUR. T1 - Statin use in spontaneous intracerebral hemorrhage. T2 - A systematic review and meta-analysis. AU - Jung, Jin-Man. AU - Choi, Jeong Yoon. AU - Kim, Hyun Jung. AU - Seo, Woo Keun. PY - 2015/10/1. Y1 - 2015/10/1. N2 - Background: Nonrandomized observational studies have been conducted to evaluate the effects of statins on clinical outcomes in patients with intracerebral hemorrhage. Several studies on the effects of statin administration in patients with intracerebral hemorrhage have been published recently, but the findings are inconsistent. Aim: To evaluate the effects of statins administered prior to hospital admission and during hospitalization on mortality and functional outcomes in patients with intracerebral hemorrhage. Summary of review: We searched for relevant literature using multiple comprehensive databases and performed a systematic review and meta-analysis. Sixteen studies met our selection criteria. Preintracerebral hemorrhage statin use was not associated with ...
TY - JOUR. T1 - Platelet Count and Function in Spontaneous Intracerebral Hemorrhage. AU - Ziai, Wendy C.. AU - Torbey, Michel T.. AU - Kickler, Thomas S.. AU - Oh, Sangjin. AU - Bhardwaj, Anish. AU - Wityk, Robert J.. PY - 2003/7. Y1 - 2003/7. N2 - Impaired platelet function has been associated with an increased propensity for intracerebral hemorrhage (ICH). The role of platelet count and dysfunction in spontaneous ICH (SICH) is poorly understood. We tested the hypotheses that patients with SICH have subtle platelet dysfunction associated with ICH progression and larger ICH size. In a retrospective case series, we compared platelet counts in patients with SICH with age-matched controls with neuromuscular disorders admitted to a Neurosciences Critical Care Unit (NCCU). In a subset of patients, platelet function was measured within one week of ICH. Computerized tomography (CT) scans were performed within 24 hours of the event and ICH volume determined by the ABC/2 method. Comparison of 43 patients ...
Background and rationale Acute intracerebral haemorrhage (ICH) results from rupture of cerebral vasculature leading to bleeding into the cerebral parenchyma. ICH represents 10-50% of stroke, depending on the population studied, is associated with significant morbidity and mortality, and has limited treatment options. The INTERACT2 trial was designed to assess the role of blood pressure lowering therapy in intracerebral haemorrhage. Guideline therapy (target systolic blood pressure [SBP] ,180 mmHg) was compared against intensive lowering (SBP ,140 mmHg). The outcomes assessed in this trial were death or major disability (according to the modified Rankin scale at 90 days) following ICH. Hyperglycaemia has been widely studied in acute illnesses as myocardial infarction, ischaemic stroke, traumatic brain injury and ICH, and is associated with adverse outcomes. The incidence of hyperglycaemia in the acute phase is due to a combination of factors: diabetic pathophysiology and stress hyperglycaemia. ...
Background and Purpose-Recently COL4A1, a gene encoding the type IV collagen a1 chain, has been found to be involved in families with autosomal-dominant porencephaly and infantile hemiparesis. In addition to neonatal stroke, some family members had experienced, during adulthood, spontaneous intracerebral hemorrhages (ICHs) and leukoencephalopathy, suggestive of underlying small-vessel disease of the brain. We now report a patient with sporadic, recurrent ICHs and a novel COL4A1 mutation.
BACKGROUND AND OBJECTIVE: Acute hypertensive response, defined as systolic blood pressure (SBP) 140 mmHg or more within 24 h of onset, is frequently observed in hemorrhagic stroke patients. Although catecholamine surge is pivotal in its pathogenesis, few studies have evaluated the relationship between admission SBP and plasma catecholamine levels.. PATIENTS AND METHODS: A prospective observational study was carried out to investigate potential differences in the acute hypertensive reaction between subarachnoid hemorrhage (SAH) and spontaneous intracerebral hemorrhage (SICH) by analyzing 200 SAH and 200 SICH patients. In each category, patients were quadrichotomized on the basis of their SBPs in emergency department: less than 140 mmHg, 140-184 mmHg, 185-219 mmHg, and 220 mmHg or more. The plasma catecholamine levels were compared among the four groups. Furthermore, multivariate regression analyses were carried out to identify variables correlated with hypertensive emergency (SBP≥185 ...
Twenty-two patients who had evidence of spontaneous intracerebral hemorrhage in brain computerized tomographic(CT) scan specially with small vascular malformations who were angiographically verified and unknown causes, were reviewed. The majority of patients were in first and second decades of life. The duration of symptoms from onset to admission showed relatively short in verified cases and even distributed from 1 day to 1 month in unknown cases. The most common presenting symptoms and signs were headache and papilledema in unknown cases. In brain CT scan, variable findings were seen as hematoma with surrounding eidence of vascular anomaly, hematoma only and blood-fluid level in verified cases, and tumor-like findings in unknown cases. The most common site of hematoma were parietal and occipital lobes in verified cases and were parietal and infratentorial area in unknown cases. The results achieved with excision of these cases were good. These small vascular malformations require special ...
Background: Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke. Despite limited effective therapy, there is no accepted clinical grading scale to predict in- hospital mortality, especially in developing nations. The purpose of this study was to assess the predictors of in- hospital mortality among a sample of Iranian patients with spontaneous ICH for use at the time of the first evaluation.Methods: This prospective study was carried from January 2010 to the end of January 2011. Demographic, clinical, and laboratory data of ICH patients were collected. Hematoma volume and perihematoma edema (PHE) were measured on brain computed tomography scan using ABC/2 formula. Logistic regression analysis was performed to determine independent variables contributing to in- hospital mortality.Results: Of a total 167 consecutive ICH patients, 98 patients met inclusion criteria. Mean ± standard deviation age of patients was 70.16 ± 12.52.
TY - CHAP. T1 - Acute hypertensive response in intracerebral hemorrhage. AU - Hassan, Ameer E.. AU - Zacharatos, Haralabos. AU - Qureshi, Adnan I. PY - 2009/1/1. Y1 - 2009/1/1. N2 - Acute hypertensive response is the elevation of blood pressure above normal and premorbid values that initially occurs within the first 24 hours of symptom onset in patients with intracerebral hemorrhage (ICH). We reviewed the existing data pertinent to acute hypertensive response derived from scientific guidelines, randomized trials, non-randomized controlled studies, and selected observational studies. Chronic hypertension and intracerebral hemorrhage Incidence of intracerebral hemorrhage and hypertension Spontaneous, non-traumatic ICH from intraparenchymal blood vessels makes up approximately 8-15% of all strokes. Approximately 80-85% are primary spontaneous ICH which are either secondary to arterial hypertension or cerebral amyloid angiopathy. It is estimated that 70% of the primary spontaneous ICH cases are ...
Of the three stroke subtypes, spontaneous intracerebral hemorrhage (ICH) has the highest death rate and the poorest prognosis in survivors. Indeed, half of ICH patients die and only 10-20 % return to...
Introduction Measuring magnetic induction phase shift (MIPS) changes as a function of cerebral hemorrhage volume has the potential for being a simple method for primary and non-contact detection of the occurrence and progress of cerebral hemorrhage. Our previous MIPS study showed that the intracranial pressure (ICP) was used as a contrast index and found the primary correlation between MIPS and ICP. Materials and Methods In this study,we theoretically deduced the approximate relationship between MIPS and ICP and carried out a comparison study between MIPS and ICP on cerebral hemorrhage in rabbits in this study. Acute cerebral hemorrhage was induced by injecting autologous blood (3 to 6mL) into the brain of rabbits in the experimental group (n=7). Results The animal experiment results showed that the MIPS decreased significantly as a function of injection volume in the experimental group and the changes of ICP and MIPS of rabbits from experimental group presented a negative correlation. We also found
Cases reported • Cerebral Hemorrhage; Hemorrhage, Cerebral; Brain Hemorrhage, Cerebral; Cerebral Parenchymal Hemorrhage; Intracerebral Hemorrhage. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Computed tomography (CT) is the most common imaging method used to investigate stroke. It demonstrates haemorrhage accurately immediately after the stroke1 but as the haematoma is broken down, the characteristic hyperdensity on CT disappears, becoming indistinguishable from infarction. This has been reported to occur by 14 days for moderately sized lesions,2 and possibly sooner for smaller haemorrhages.3. Primary intracerebral haemorrhage is thought to cause more severe stroke symptoms than an infarct of the same size,4,5 and so primary intracerebral haemorrhage is considered to be a less frequent cause of mild than severe stroke. However, it is possible that this apparently low incidence is an artefact caused by the misclassification of mild stroke resulting from primary intracerebral haemorrhage as ischaemic stroke because of delay in CT scanning in epidemiological studies.6 The actual proportion of primary intracerebral haemorrhages among mild strokes is unknown. Thus there is no information ...
Details of the image Grade IV germinal matrix haemorrahge with intraventricular extension and hydrocephalus Modality: MRI (FLAIR)
Details of the image Grade IV germinal matrix haemorrahge with intraventricular extension and hydrocephalus Modality: MRI (DWI)
Varol and Ozaydin1 raise an important question about the effects of antihypertensive drugs and statins on arterial stiffness. In fact, antihypertensive drugs reduce large arterial stiffness, partly independently of blood pressure reduction, suggesting specific pharmacological effects on arterial remodeling.2 Furthermore, statins and other cholesterol-reducing agents have been shown to have beneficial effects on wave reflection and aortic stiffness reduction in several patient groups.3 In our study,4 25 out of 39 hypertensive patients with deep intracerebral hemorrhage (ICH) and 11 out of 15 hypertensive patients with lobar ICH received antihypertensive drugs, whereas 4 patients with deep ICH and 3 with lobar ICH received statins (Table 1). Fisher test showed no significant differences between the two groups with regard to patients treated with antihypertensive drugs (P=1, not significant) and with statins (P=0.41, not significant), confirming our hypothesis that arterial stiffness may play a key ...
The annual incidence rate of primary intracerebral hemorrhage (ICH) in Izumo City, Japan, appears to be the highest rate among those reported. Despite improvement of management and surgical therapy, the overall morbidity and mortality after ICH are still high. The author investigated the risk factor …
The epinephrine (E) and norepinephrine (NE) urinary excretion before and after a mild emotional stimulus (ES) was determined in 22 patients with cerebral infarction and 30 patients with cerebral hemorrhage, as well as in 18 normotensive and 18 hypertensive controls. In patients with cerebral infarction, the majority normotensive, the emotional stimulus induced a significant increase in NE excretion, but non-significant alterations in E excretion. Similar changes were noted in normotensive controls. In patients with cerebral hemorrhage, almost all hypertensive, and in hypertensive controls, ES brought about a consistent rise in E excretion without influencing significantly the NE excretion. The presence of a constant increase in E excretion after a mild emotion not only in patients with cerebral hemorrhage but also in subjects with uncomplicated essential hypertension, suggests that the E release found in patients with cerebral hemorrhage is related to the hypertensive state pre-existing the ...
Other than surgery, alternative treatment like acupuncture is the best way to treat brain hemorrhage. This is because acupuncture and herbal medicine may help controlling the blood pressure which to avoid repeated bleeding.. Alternative Brain Hemorrhage Treatment: Brain hemorrhage can be treated with THE TOLEs neuro acupuncture brain hemorrhage treatment and brain hemorrhage herbal medicine. For the recovery time, its all depend on how long and how severe the problem is. You can also order our brain hemorrhage herbs medicine through the net and we will courier the brain hemorrhage herbs medicine to you.. ...
Second time brain hemorrhage - MedHelps Second time brain hemorrhage Center for Information, Symptoms, Resources, Treatments and Tools for Second time brain hemorrhage. Find Second time brain hemorrhage information, treatments for Second time brain hemorrhage and Second time brain hemorrhage symptoms.
Intracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated antioxidant system, negatively regulate nuclear factor-κB (NF-κB) and nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathways, but its role and potential molecular mechanisms in the pathology following ICH remain unclear. The present study aimed to explore the effects of ILG after ICH and underlying mechanisms. ICH model was induced by collagenase IV (0.2 U in 1 μl sterile normal saline) in male Sprague-Dawley rats weighing 280-320 g. Different doses of ILG (10, 20, or 40 mg/kg) was administrated intraperitoneally at 30 min, 12 h, 24 h, and 48 h after modeling, respectively. Rats were intracerebroventricularly administrated with control scramble small interfering RNA (siRNA) or Nrf2 siRNA at 24 h before ICH induction, and after 24 h,
Background and purpose The pathogenesis of brain injury after intracerebral hemorrhage is thought to be due to mechanical damage followed by ischemic, cytotoxic, and inflammatory changes in the underlying and surrounding tissue. In recent years, there has been a greater research interest into the various inflammatory biomarkers and growth factors that are secreted during intracerebral hemorrhage. The biomarkers investigated in this study are tumor necrosis factor alpha (TNF alpha), C-reactive protein (CRP), homocysteine (Hcy), and vascular endothelial growth factor (VEGF). The aim of this study was to further investigate the effects of these biomarkers in predicting the acute severity outcome of intracerebral hemorrhage (ICH). Methods We conducted a retrospective chart review of patients with spontaneous ICH with TNF alpha, CRP, VEGF, and Hcy levels drawn on admission. Forty-two patients with spontaneous ICH with at least one of the above labs were included in the study. Primary outcomes
Intraparenchymal hemorrhage (IPH) is one form of intracerebral bleeding in which there is bleeding within brain parenchyma. The other form is intraventricular hemorrhage (IVH). Intraparenchymal hemorrhage accounts for approx. 8-13% of all strokes and results from a wide spectrum of disorders. It is more likely to result in death or major disability than ischemic stroke or subarachnoid hemorrhage, and therefore constitutes an immediate medical emergency. Intracerebral hemorrhages and accompanying edema may disrupt or compress adjacent brain tissue, leading to neurological dysfunction. Substantial displacement of brain parenchyma may cause elevation of intracranial pressure (ICP) and potentially fatal herniation syndromes. Clinical manifestations of intraparenchymal hemorrhage are determined by the size and location of hemorrhage, but may include the following: Hypertension, fever, or cardiac arrhythmias Nuchal rigidity Subhyaloid retinal hemorrhages Altered level of consciousness Anisocoria, ...
TY - JOUR. T1 - Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats. AU - Park, Joohyun. AU - Kim, Jong Youl. AU - Choi, Seong Kyoon. AU - Kim, Jae Young. AU - Kim, Jae Hwan. AU - Jeon, Won Bae. AU - Lee, Jong Eun. PY - 2017/8. Y1 - 2017/8. N2 - Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. ...
A 4-year-old previously healthy boy presented with a non-traumatic right parietal hemorrhage. A second life-threatening left cerebral hemorrhage occurred three weeks later and was decompressed with a craniotomy. Transthoracic echocardiography revealed a hypermobile elongated tumor of the mitral valve. The cardiac tumor was successfully resected three weeks after the craniotomy. Histological examination of the cardiac tumor revealed a papillary lesion of spindle cells with smooth muscle cell differentiation. In view of the histological findings and the clinical symptoms, a cellular myofibroblastic tumor was considered the most likely diagnosis in our patient. Although a cardiac tumor is a rare cause of a cerebral hemorrhage, a cardiac evaluation is recommended in pediatric patients with a cerebral hemorrhage of unknown etiology ...
Authors: Beslow LA, Abend NS, Gindville MC, Bastian RA, Licht DJ, Smith SE, Hillis AE, Ichord RN, Jordan LC.. IMPORTANCE Seizures are believed to be common presenting symptoms in neonates and children with spontaneous intracerebral hemorrhage (ICH). However, few data are available on the epidemiology of acute symptomatic seizures or the risk for later epilepsy. OBJECTIVE To define the incidence of and explore risk factors for seizures and epilepsy in children with spontaneous ICH. Our a priori hypotheses were that younger age at presentation, cortical involvement of ICH, acute symptomatic seizures after presentation, ICH due to vascular malformation, and elevated intracranial pressure requiring urgent intervention would predict remote symptomatic seizures and epilepsy. DESIGN Prospective cohort study conducted between March 1, 2007, and January 1, 2012. SETTING Three tertiary care pediatric hospitals. PARTICIPANTS Seventy-three pediatric subjects with spontaneous ICH including 20 perinatal ...
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TY - JOUR. T1 - The Role of FEIBA in Reversing Novel Oral Anticoagulants in Intracerebral Hemorrhage. AU - Dibu, Jamil R.. AU - Weimer, Jonathan M.. AU - Ahrens, Christine. AU - Manno, Edward. AU - Frontera, Jennifer A.. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Background: Activated prothrombin complex concentrates factor eight inhibitor bypassing activity (FEIBA) has been recommended for reversing novel oral anticoagulants (NOAC) in the context of intracerebral hemorrhage (ICH), though few clinical studies report its use. Methods: A prospective study of patients with spontaneous ICH was conducted from May 2013 to May 2015. Hospital complications including hemorrhage (gastrointestinal bleeding, anemia requiring transfusion, and surgical site bleeding) and thrombosis (pulmonary embolus, deep vein thrombosis, ischemic stroke, and myocardial infarction) were recorded. All ICH patients underwent baseline head CT and a follow-up stability scan in 6 h. NOAC taken within 48 h of presentation was reversed ...
TY - JOUR. T1 - Prognostic significance of delayed intraventricular haemorrhage in the INTERACT studies. AU - Moullaali, Tom J.. AU - Sato, Shoichiro. AU - Wang, Xia. AU - Rabinstein, Alejandro A.. AU - Arima, Hisatomi. AU - Carcel, Cheryl. AU - Chen, Guofang. AU - Robinson, Thompson. AU - Heeley, Emma. AU - Chan, Edward. AU - Delcourt, Candice. AU - Stapf, Christian. AU - Cordonnier, Charlotte. AU - Lindley, Richard I.. AU - Chalmers, John. AU - Anderson, Craig S.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Background and purpose Intraventricular extension of intracerebral haemorrhage (ICH) predicts poor outcome, but the significance of delayed intraventricular haemorrhage (dIVH) is less well defined. We determined the prognostic significance of dIVH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). Methods Pooled analyses of the INTERACT CT substudies - international, multicentre, prospective, open, blinded end point, randomised controlled trials of ...
A number of studies have cited immune cell infiltration as a mechanism for secondary injury following intracerebral hemorrhage. However, the role of monocytes remains poorly understood. We hypothesized that monocytes are a beneficial cell type that help remove extravasated blood and other pathogenic substances that enter brain parenchymal tissue during a hemorrhagic stroke. Using macrophage Fas-induced apoptosis (MAFIA) mice, this study documents a time course of monocyte infiltration into brain tissue. We then systemically knocked down monocytes prior to initiating an intracerebral hemorrhage, and studied the motor and cognitive outcomes relative to a vehicle treated group. The genetic alteration present in MAFIA mice causes the co-expression of green fluorescent protein and a suicide protein, exclusively in monocytes and dendritic cells. We established a time course of monocyte infiltration by counting cells expressing green fluorescent protein in brain parenchymal tissue at four time points ...
The use of Minimally Invasive Parafascicular Surgery (MIPS) techniques for removal of traumatic hematoma is encouraging, innovative and promising. Those are the insights from Julian Bailes, MD, Chair of the Joint Section on Neurotrauma and Critical Care for the American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS), following the evidence highlighted in two abstracts on the subject at the recent AANS Annual Scientific Meeting.. Results from the 10-patient multi-center study, led by Jefferson Chen, MD, PhD, from the University of California Irvine, concluded that techniques using Minimally Invasive Parafascicular Surgery (MIPS) may be used effectively and safely to remove deep subcortical hemorrhages and may improve the patients hospital course and ultimate neurological outcome. Technologies used in the MIPS approach include the NICO BrainPathâ for subcortical access and Myriadâ for hemorrhage evacuation.. This is the first multi-center experience ...
Background: Antiplatelet treatment remains the first choice for primary and secondary prevention of vascular diseases; even so, expected benefits may be offset by risk of bleeding, particularly cerebral hemorrhage. The aim of this study was to assess the influence of antiplatelet treatment on clinical outcome at hospital discharge. Materials and Methods: Consecutive patients with first-ever stroke due to a primary intraparenchymal hemorrhage were prospectively identified over a 4-year period (2000â€2003). Data on hemorrhage location, vascular risk factors, and antiplatelet and anticoagulant treatment were collected. At discharge, outcome was measured using the modified Rankin Scale (disabling stroke ≥3). Patients treated with anticoagulant therapy were excluded from the study. Results: Of 457 consecutive patients with cerebral hemorrhage, 94 (20.5%) had been taking antiplatelet agents. The treated patients (mean age for antiplatelet group 78.9 ± 9.0 years) were older than the ...
The germinal matrix is the site of proliferating neuronal and glial precursors in the developing brain, which is located above the caudate nucleus, in the floor of the lateral ventricle, and caudothalamic groove. The germinal matrix contains a rich network of fragile thin-walled blood vessels. Hence the microcirculation in this particular area is extremely sensitive to hypoxia and changes in perfusion pressure. It is most frequent before 35 weeks gestation and is typically seen in very low birth-weight (,1500g) premature infants, because they lack the ability for auto regulation of cerebral blood flow. Consequently, increased arterial blood pressure in these blood vessels leads to rupture and hemorrhage into germinal matrix.[2]. ...
Background There is much uncertainty about the effects of early lowering of elevated blood pressure (BP) after acute intracerebral haemorrhage (ICH). Our aim was to assess the safety and efficiency of this treatment, as a run-in phase to a larger trial.. Methods Patients who had acute spontaneous ICH diagnosed by CT within 6 h of onset, elevated systolic BP (150-220 mm Hg), and no definite indication or contraindication to treatment were randomly assigned to early intensive lowering of BP (target systolic BP 140 mm Hg; n=203) or standard guideline-based management of BP (target systolic BP 180 mm Hg; n=201). The primary efficacy endpoint was proportional change in haematoma volume at 24 h; secondary efficacy outcomes included other measurements of haematoma volume. Safety and clinical outcomes were assessed for up to 90 days. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00226096.. Findings Baseline characteristics of patients were similar ...
TY - JOUR. T1 - Subarachnoid Extension of Intracerebral Hemorrhage and 90-Day Outcomes in INTERACT2. AU - Chen, Guofang. AU - Arima, Hisatomi. AU - Wu, Guojun. AU - Heeley, Emma. AU - Delcourt, Candice. AU - Zhang, Peiying. AU - Rabinstein, Alejandro. AU - Robinson, Thompson. AU - Stapf, Christian. AU - Huang, Yining. AU - Song, Lili. AU - Yang, Jie. AU - Wang, Xia. AU - Li, Qiang. AU - Chen, Xiaoying. AU - Chalmers, John. AU - Anderson, Craig. AU - INTERACT2 Investigators, null. PY - 2014/1. Y1 - 2014/1. N2 - Background and Purpose-The prognostic significance of subarachnoid extension of intracerebral hemorrhage was determined in the INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT2) study. Methods-INTERACT2 was an open randomized controlled trial of early intensive compared with guideline-recommended blood pressure lowering in patients with elevated systolic blood pressure within 6 hours of intracerebral hemorrhage. Independent predictors of death or major ...
Few animal models of stroke have created haematomas that mimic the processes seen in humans. We developed a new model of intracerebral haemorrhage (ICH) in rats by inducing acute-on-chronic hypertension that more closely mimics the human condition than existing models. We also examined profiles of ICH development in the genetically hypertensive Spontaneously Hypertensive Rat and in normotensive rats made hypertensive by induction of renal disease via renal artery obstruction or kidney resection ...
Intracerebral hemorrhage (ICH) causes 10% to 15% of first-ever strokes, with a 30-day mortality rate of 35% to 52% with only 20% expected to be functionally independent at 6 months. No medical or surgical interventions have been found to alter the natural evolution of this disease. The high risk for mortality and poor outcomes seems to occur despite relatively small hematoma volumes and small amounts of neuronal tissue at risk for injury. The reasons for this observation remain unknown; however perihematomal edema formation and inflammation that follows ICH seems to play an important role.. The Simvastatin for Intracerebral Hemorrhage Study is a prospective double blinded placebo controlled randomized (1:1) clinical trial that compares outcomes in patients receiving generic simvastatin 80 mg for 14 days or until death or discharge with patients in the placebo group.. The hypothesis for our study is that statins ameliorate perihematomal edema evolution thereby reducing mortality and improving ...
TY - JOUR. T1 - The effect of activated factor VII for intracerebral hemorrhage beyond 3 hours versus within 3 hours. AU - Hallevi, Hen. AU - Gonzales, Nicole R.. AU - Barreto, Andrew D.. AU - Martin-Schild, Sheryl. AU - Albright, Karen C.. AU - Noser, Elizabeth A.. AU - Illoh, Kachi. AU - Khaja, Aslam M.. AU - Allison, Teresa. AU - Escobar, Miguel A.. AU - Shaltoni, Hashem. AU - Grotta, James C.. PY - 2008/2/1. Y1 - 2008/2/1. N2 - BACKGROUND AND PURPOSE - Recombinant-activated factor VII (rFVIIa) is an investigational treatment for intracerebral hemorrhage (ICH). We have evaluated the drugs treatment effect based on time to treatment. METHODS - ICH patients treated up to 4 hours from symptom onset were divided based on time to treatment: ≤3 hours (3H) and 3 to 4 hours (4H). Head CT was done at baseline and 24 hours. Outcome measures included: ICH growth at 24 hours, mortality, favorable outcome and discharge disposition. A cohort of nontreated matched ICH patients was used to asses the ...
Background- Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age. Methods and ... read more Results- We studied a prospective multicenter university hospital-based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: ,55, 55 to 65, 65 to 75, and ≥ 75 years, and mean differences with 95% CIs in relation to the reference age group. Patients aged ,55 years were significantly more often of non-white origin (in particular in spontaneous intracerebral hemorrhage and aneurysmal ...
Looking for hemorrhagic infarct? Find out information about hemorrhagic infarct. Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction. a focus of organ or tissue necrosis resulting... Explanation of hemorrhagic infarct
Brain Hemorrhage Pipeline Review, H1 2012, provides an overview of the Brain Hemorrhage therapeutic pipeline. This report provides information on the therapeutic development for Brain Hemorrhage, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Brain Hemorrhage. Brain Hemorrhage - Pipeline Review, H1 2012 is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team ...
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BACKGROUND:Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function following intracerebral hemorrhage (ICH). MATERIAL AND METHODS:Recombinant human ANGPTL4 (rhANGPTL4; 40 µg/kg) or a vehicle was administered intraperitoneally 5 min prior to bacterial collagenase-induced ICH in male C57/B6J mice. Behavioral tests were performed prior to ICH and at days 1, 3, 7, 14, 21, and 28 after ICH. Brain edema and hematoma volume were examined separately using the wet weight/dry weight method and hematoxylin-eosin staining. The integrity of the tight and adherens junctions was quantified via immunofluorescence. The ultrastructure of the blood-brain barrier (BBB) was examined using transmission electron microscopy. Vascular endothelial (VE)-cadherin, claudin-5, Src, and
Objective: Hypertensive intracerebral hemorrhage (HICH) is one of the common multiple diseases in neurology. Patients with severe HICH have high risk of disability and poor prognosis.. Methods: In order to explore the clinical effect of mild hypothermia combined with micro-traumatic evacuation of cerebral hemorrhage in the treatment of severe HICH, 136 patients with severe HICH were selected and divided into control group and study group using random number table method, 68 each group. The control group was treated with micro-traumatic evacuation of cerebral hemorrhage on the basis of conventional symptomatic treatment, while the study group was treated with mild hypothermia combined with micro-traumatic evacuation of cerebral hemorrhage on the basis of conventional symptomatic treatment. After treatment, the two groups were followed up for eight weeks.. Results: The overall effective rate, residual hematoma volume, rebleeding rate, National Institute of Health stroke scale (NIHSS) score, ...
Corticosteroids for aneurysmal subarachnoid haemorrhage and primary intracerebral haemorrhage Edited (no change to conclusions) answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
TY - JOUR. T1 - Early elective surgical exploration of spontaneous intracerebral hematomas of unknown origin. T2 - Clinical article. AU - Elhammady, Mohamed. AU - Baskaya, Mustafa K.. AU - Heros, Roberto. PY - 2008/12/1. Y1 - 2008/12/1. N2 - Object. The management of non-life threatening spontaneous intraparenchymal hemorrhage with no obvious medical etiology in patients and the lack of findings on images has not been clearly defined. In general, the current practice is to treat these patients conservatively and repeat studies to rule out a treatable cause 6 weeks to 3 months later; more often than not these repeated studies fail to reveal any findings, and the patient is treated conservatively. For years, the senior author (R.C.H.) has treated these patients with early surgical exploration. This study was undertaken prospectively to ascertain the frequency of positive findings during surgical exploration. Methods. Between 2000 and 2007, the authors prospectively collected data from 9 cases (4 ...
The study population comprised 288 consecutive patients with aSAH. The mean total hemorrhage volume was 74.9 ml. Thirty-eight patients (13.2%) developed seizures. The mean hemorrhage volume in patients who developed seizures was significantly higher than that in patients with no seizures (mean difference 17.3 ml, p = 0.01). In multivariate analysis, larger hemorrhage volume on initial CT scan and hemorrhage volume , 50 ml (OR 2.81, p = 0.047, 95% CI 1.03-7.80) were predictive of seizures. Forty-eight patients (17%) developed shunt-dependent hydrocephalus. The mean hemorrhage volume in patients who developed shunt-dependent hydrocephalus was significantly higher than that in patients who did not (mean difference 17.2 ml, p = 0.006). Larger hemorrhage volume and hemorrhage volume , 50 ml (OR 2.45, p = 0.03, 95% CI 1.08-5.54) were predictive of shunt-dependent hydrocephalus. Hemorrhage volume had adequate discrimination for the development of seizures (AUC 0.635) and shunted hydrocephalus (AUC ...
The main pathophysiological factors of ICH include hematoma size and edema [38]. The formation of edema, which is mainly caused by disruption of the BBB following ICH, is associated with patient outcome. The BBB is composed of endothelial cells, tight junction proteins, astrocyte end-feet, and pericytes, which have the function of maintaining homeostasis of the neuro-parenchymal microenvironment [6]. Loss of BBB integrity is an important pathophysiological change that contributes to initiation of the inflammatory cascade, edema formation, and ultimately poor outcome [39]. In this study, the effect of MSCs on BBB leakage in ICH rats and relevant mechanisms were investigated after intravenous transplantation of MSCs.. Besides endothelial cell activation, vascular ONOO−, which is formed by NO and superoxide anion, is closely related to BBB leakage [37]. Studies have already shown that ONOO− alone is sufficient to induce BBB leakage, endothelial dysfunction, and neurodegeneration [40,41]. ...
TY - JOUR. T1 - Statistical analysis plan for pooled individual patient data from two landmark randomized trials (INTERACT2 and ATACH-II) of intensive blood pressure lowering treatment in acute intracerebral hemorrhage. AU - Moullaali, Tom J. AU - Wang, Xia. AU - Martin, Renee H. AU - Shipes, Virginia B. AU - Qureshi, Adnan I. AU - Anderson, Craig S. AU - Palesch, Yuko Y. PY - 2018/11/12. Y1 - 2018/11/12. N2 - BACKGROUND: There is persistent uncertainty over the benefits of early intensive systolic blood pressure lowering in acute intracerebral hemorrhage. In particular, over the timing, target, and intensity of systolic blood pressure control for optimum balance of potential benefits (i.e. functional recovery) and risks (e.g. cerebral ischemia).AIMS: To determine associations of early systolic blood pressure lowering parameters and outcomes in patients with a hypertensive response in acute intracerebral hemorrhage. Secondary aims are to identify the modifying effects of patient characteristics ...
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. Rodrigues MA, Samarasekera N, Lerpiniere C, et al. Lancet Neurol 2018; 17:232-240. Abstract BACKGROUND: Identification of lobar spontaneous intracerebral haemorrhage associated with cerebral amyloid angiopathy (CAA) is important because it is associated…
Cerebral amyloid angiopathy (CAA) has been associated with atypical dementia and a variety of other neurological disorders. Intracerebral hemorrhage is the most striking manifestation of CAA. A 63-year-old patient is described who sustained four intracerebral hemorrhages although he had no predisposing factors other than CAA. The neurological and pathological features of CAA are reviewed, with particular emphasis on the problem of CAA-associated intracerebral hemorrhage. On the basis of the experience with this case, it is recommended that adjacent brain parenchyma be biopsied in all patients undergoing evacuation of intracerebral hematomas of unclear etiology. ...
Post-admission hematoma expansion in patients with intracerebral hemorrhage (ICH) comprises a simultaneous major clinical problem and a possible target for medical intervention. In any case, the ability to predict and observe hematoma expansion is of great clinical importance. We review radiological concepts in predicting and observing post-admission hematoma expansion. Hematoma expansion can be observed within the first 24 h after symptom onset, but predominantly occurs in the early hours. Thus capturing markers of on-going bleeding on imaging techniques could predict hematoma expansion. The spot sign observed on computed tomography angiography is believed to represent on-going bleeding and is to date the most well investigated and reliable radiological predictor of hematoma expansion as well as functional outcome and mortality. On non-contrast CT, the presence of foci of hypoattenuation within the hematoma along with the hematoma-size is reported to be predictive of hematoma expansion and ...
Intracerebral hemorrhage (ICH) often produces severe neurological deficits in survivors, which is closely related with secondary corticospinal tract (CST) injury. Rodent models of ICH have greatly promoted the understanding of histopathology underlying brain injury and were employed widely for exploring therapeutic strategies. This study investigated WD in pyramidal tract, as part of CST, after experimental ICH using diffusion tensor imaging (DTI) and T2-weighted imaging as well as with histological correlations. The results demonstrated DTI as a valuable tool for detecting WD in early phase and for longitudinal monitoring of its progress at different stages with more accuracy than T2-weighted imaging ...
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We searched our electronic database for all patients aged 18 years or above who developed first ICH in the presence of anticoagulation with warfarin for non-valvular AF (ICH-W group) from the three hospitals, and matched them with a comparison group (ICH-C group) without taking warfarin at a 1:1 ratio for age (±1 year), gender, and admission year. The comparison group comprised patients from the medical unit of PMH (principal study centre) who had a first episode of ICH without anticoagulation, regardless of any AF. Patients with isolated subdural, subarachnoid, or intraventricular haemorrhage were excluded. We retrieved and compared the data regarding neurological impairment and investigation findings, estimated the ICH volume on CT through the ABC/2 method, and calculated the ICH score.3 4 Hospital mortality and 6-month modified Rankin Scale score (mRS, 0-6) were selected as primary and secondary outcomes, respectively. We used independent sample t test and Mann-Whitney U test for univariate ...
Authors: Beslow LA, Abend NS, Gindville MC, Bastian RA, Licht DJ, Smith SE, Hillis AE, Ichord RN, Jordan LC.. IMPORTANCE Seizures are believed to be common presenting symptoms in neonates and children with spontaneous intracerebral hemorrhage (ICH). However, few data are available on the epidemiology of acute symptomatic seizures or the risk for later epilepsy. OBJECTIVE To define the incidence of and explore risk factors for seizures and epilepsy in children with spontaneous ICH. Our a priori hypotheses were that younger age at presentation, cortical involvement of ICH, acute symptomatic seizures after presentation, ICH due to vascular malformation, and elevated intracranial pressure requiring urgent intervention would predict remote symptomatic seizures and epilepsy. DESIGN Prospective cohort study conducted between March 1, 2007, and January 1, 2012. SETTING Three tertiary care pediatric hospitals. PARTICIPANTS Seventy-three pediatric subjects with spontaneous ICH including 20 perinatal ...
Title: Assessment of Short- and Long-Term Outcomes of Patients Hospitalized With Intracerebral Hemorrhage. VOLUME: 9 ISSUE: 1. Author(s):Chih-Ming Lin and Wayne Feng. Affiliation:Beth Israel Deaconess Medical Center, Department of Neurology, Stroke Division, Boston, USA.. Keywords:Cerebral hemorrhage, death, recurrent stroke, myocardial infarction, outcome, south carolina, Caucasian, ICH, myocardial, Intracerebral hemorrhage, stroke belt, CAs, MI, hypertension, hyperlipidemia, racial disparity. Abstract: The aim of this study was to assess short- and long-term outcomes of patients hospitalized with intracerebral hemorrhage (ICH) in South Carolina. Patients with a primary diagnosis of ICH (ICD-9-CM code 431) discharged during 2002 were identified in the South Carolina hospital discharge database. Kaplan-Meier estimates of recurrent stroke, myocardial infarct, vascular death, all-cause death, and composite events were calculated at 1 month, 6 months, and 1, 2, 3, and 4 years. Age- and ...
Title:Glucose Levels and Outcome After Primary Intraventricular Hemorrhage. VOLUME: 16 ISSUE: 1. Author(s):Rui Guo, Ruiqi Chen, Chao You, Lu Ma, Hao Li and Yuan Fang*. Affiliation:Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan. Keywords:Primary intraventricular hemorrhage, glucose, risk factors and outcome, hyperglycemia, cerebral injuries, intraventricular hemorrhage.. Abstract:. Background and Purpose: Hyperglycemia is reported to be associated with poor outcome in patients with spontaneous Intracerebral Hemorrhage (ICH), but ...
We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Abeta) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Abeta, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.. ...
TY - JOUR. T1 - Majority of 30-day readmissions after intracerebral hemorrhage are related to infections. AU - Lord, Aaron S.. AU - Lewis, Ariane. AU - Czeisler, Barry. AU - Ishida, Koto. AU - Torres, Jose. AU - Kamel, Hooman. AU - Woo, Daniel. AU - Elkind, Mitchell S.V.. AU - Boden-Albala, Bernadette. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Background and Purpose - Infections are common after intracerebral hemorrhage, but little is known about the risk of serious infection requiring readmission after hospital discharge. Methods - To determine if infections are prevalent in patients readmitted within 30 days of discharge, we performed a retrospective cohort study of patients discharged from nonfederal acute care hospitals in California with a primary diagnosis of intracerebral hemorrhage between 2006 and 2010. We excluded patients who died during the index admission, were discharged against medical advice, or were not California residents. Our main outcome was 30-day unplanned readmission with ...
TY - JOUR. T1 - Oedema extension distance in intracerebral haemorrhage. T2 - Association with baseline characteristics and long-term outcome. AU - on behalf of the VISTA-ICH Collaborators. AU - Hurford, Robert. AU - Vail, Andy. AU - Heal, Calvin. AU - Ziai, Wendy C.. AU - Dawson, Jesse. AU - Murthy, Santosh B.. AU - Wang, Xia. AU - Anderson, Craig S.. AU - Hanley, Daniel F.. AU - Parry-Jones, Adrian R.. N1 - Publisher Copyright: © European Stroke Organisation 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/9/1. Y1 - 2019/9/1. N2 - Introduction: Oedema extension distance is a derived parameter that may reduce sample size requirements to demonstrate reduction in perihaematomal oedema in early phase acute intracerebral haemorrhage trials. We aimed to identify baseline predictors of oedema extension distance and its association with clinical outcomes. Patients and methods: Using Virtual International Stroke Trials Archive-Intracerebral Haemorrhage, first Intensive ...
OBJECTIVE: Early hematoma expansion is a known cause of morbidity and mortality in patients with intracerebral hemorrhage (ICH). The goal of this study was to identify clinical predictors of ICH growth in the acute stage.. MATERIALS AND METHODS: We studied 201 patients with acute (,6h) deep ganglionic ICH. Patients underwent CT scan at baseline and hematoma expansion (,33% or ,12.5ml increase) was determined on the second scan performed within 24h. Fourteen clinical and neuroimaging variables (age, gender, GCS at admission, hypertension, diabetes mellitus, kidney disease, stroke, hemorrhagic, antiplatelet use, anticoagulant use, hematoma density heterogeneity, hematoma shape irregularity, hematoma volume and presence of IVH) were registered. Additionally, blood pressure was registered at initial systolic BP (i-SBP) and systolic BP 1.5h after admission (1.5h-SBP). The discriminant value of the hematoma volume and 1.5h-SBP for hematoma expansion were determined by the receiver operating ...
Mortality from hereditary cerebral haemorrhage with amyloidosis, Dutch type : the impact of sex, parental transmission and year of birth ...
Brain vascular malformations, including arteriovenous malformations (AVM), cavernous malformations (CVM) and aneurysms, are a source of life-threatening risk of intracranial hemorrhage. The etiology and pathogenesis are unknown. There is no medical therapy presently available. Prevention of spontaneous intracerebral hemorrhage (ICH) is the primary reason to treat brain vascular malformations. The goal of this study is to: begin pilot studies to lay the groundwork for future clinical trials to develop medical therapy to decrease ICH risk.. Matrix metalloproteinases (MMPs) regulate the extracellular matrix in association with various hemorrhagic brain disorders. MMP-9 has been most consistently associated with vascular wall instability and hemorrhagic brain disorders. Doxycycline, a non-specific MMP inhibitor, may enhance vascular stability, thus reducing the risk of spontaneous hemorrhage in brain vascular malformations by decreasing MMP-9 activity. ...
TY - JOUR. T1 - Initial troponin level as a predictor of prognosis in patients with intracerebral hemorrhage. AU - Chung, Pil Wook. AU - Won, Yu Sam. AU - Kwon, Young Joan. AU - Choi, Chum Sik. AU - Kim, Byung Moon. PY - 2009. Y1 - 2009. N2 - Objective: It has been suggested that elevated cardiac troponin T (cTnT) level is a marker of increased risk of mortality in acute ischemic stroke and subarachnoid hemorrhage (SAH). However, the association of serum cTnT level and prognosis of intracerebral hemorrhage (ICH) has been sparsely investigated. The aim of this study was to identify the relationship between cTnT level and the outcome in patients with spontaneous ICH. Methods: We retrospectively investigated 253 patients identified by a database search from records of patients admitted in our department for ICH between January 1, 2003 and December 31, 2007. The patients were divided into 2 groups; the patients in group 1 (n=225) with serum cTnT values of 0.01 ng/mL or less, and those in group 2 ...
BACKGROUND: Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. OBJECTIVE: The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous intracerebral haemorrhage (ICH). DESIGN: The TICH-2 (Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage) study was a pragmatic, Phase III, prospective, double-blind, randomised placebo-controlled trial. SETTING: Acute stroke services at 124 hospitals in 12 countries (Denmark, Georgia, Hungary, Ireland, Italy, Malaysia, Poland, Spain, Sweden, Switzerland, Turkey and the UK). PARTICIPANTS: Adult patients (aged ≥ 18 years) with ICH within 8 hours of onset. EXCLUSION CRITERIA: Exclusion criteria were ICH secondary to anticoagulation, thrombolysis, trauma or a known underlying structural abnormality; patients for whom tranexamic acid was thought to be contraindicated; prestroke dependence (i.e. patients with a modified Rankin Scale [mRS] ...
TY - JOUR. T1 - Endoglin gene polymorphism as a risk factor for sporadic intracerebral hemorrhage. AU - Alberts, M. J.. AU - Davis, J. P.. AU - Graffagnino, C.. AU - McClenny, C.. AU - Delong, D.. AU - Granger, C.. AU - Herbstreith, M. H.. AU - Boteva, K.. AU - Marchuk, D. A.. AU - Roses, A. D.. PY - 1997/5. Y1 - 1997/5. N2 - Intracerebral hemorrhage (ICH) is a common and serious type of stroke. Recent studies have shown that inherited factors that affect the development of the vessel wall can increase the risk of ICH. We studied endoglin as a candidate gene in patients with sporadic ICH, since mutations in this gene can cause telangiectasia formation. One hundred three patients with sporadic ICH and 202 controls were studied. The polymerase chain reaction and single- strand conformational polymorphism analysis were used to screen for mutations in exon 7 of the endoglin gene. No coding mutations in exon 7 were identified in the ICH patients or controls. A 6-base intronic insertion was found 26 ...
Expert data generally recommends permissive hypertension (220/120mm Hg) if not treated with thrombolytics for the first 24 hours. Acute hemorrhagic stroke presents a particularly difficult situation. Blood pressures tend to run high in these patients and this has been found to be an independent predictor of poor prognosis. The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) enrolled 404 patients after acute intracerebral hemorrhage to either an intensive blood pressure lowering arm (≤140mmHg in one hour maintained for seven days) or guideline based therapy (goal systolic of 180mmHg). The first phase of this study published in 2008 found intensive lowering of blood pressure was feasible and associated with a decreased relative risk of hematoma growth. The primary outcome in the final analysis (INTERACT2) was death or major disability using the modified Rankin score (mRS). There was a significantly lower mRS in patients undergoing intensive therapy with no ...
I Subependymal hemorrhage into one or both germinal matrices II Germinal matrix hemorrhage with intraventricular extension, no hydrocephalus III Germinal
Thanks to Dr John Williamson for lending us this episode that he recorded for another clinically-focused neurology podcast - Neuropodcases.. Listen in as he chats with Associated Professor Nawaf Yassi about intracerebral haemorrhage. They discuss hypertensive ICH, intraventricular extension, amyloid ICH, role of surgery, how to approach antithrombotics and ICH in younger patients. Its a fascinating conversation with plenty of clinical pearls.. We would highly encourage you to have a look at Johns podcast over at https://www.neuropodcases.co.uk/ where you will also find imaging referred to in this podcast.. ...
2012 (English)In: Haemophilia, ISSN 1351-8216, E-ISSN 1365-2516, Vol. 18, no 5, e381-e383 p.Article in journal, Letter (Refereed) Published ...
TY - JOUR. T1 - Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. AU - Lee, Jin Moo. AU - Yin, Kejie. AU - Hsin, Idar. AU - Chen, Shawei. AU - Fryer, John D.. AU - Holtzman, David M.. AU - Hsu, Chung Y.. AU - Xu, Jian. PY - 2005/3/15. Y1 - 2005/3/15. N2 - Spontaneous intracerebral hemorrhage (ICH) is one of the most recognized complications of cerebral amyloid angiopathy (CAA), but little is known about the molecular pathogenesis of this life-threatening complication. In this review, we present preliminary evidence which suggests that the extracellular-matrix-degrading protease, matrix metalloproteinase-9 (MMP-9), may play a role in the development of spontaneous ICH resulting from CAA. The amyloid-beta peptide (Aβ) induced the synthesis, cellular release, and activation of MMP-9 in murine cerebral endothelial cells (CECs), resulting in increased extracellular matrix (ECM) degradation. Furthermore, in a mouse model of CAA (APPsw transgenic mice), MMP-9 ...
In patients with cerebral venous thrombosis (CVT) the incidence of intracerebral hemorrhage (ICH) is estimated at about 37% and subarachnoid hemorrhage (SAH) at 1% of patients. A case with coincident occurrence of ICH, SAH and CVT in a patient with cerebral amyloid angiopathy (CAA) is reported....
TY - JOUR. T1 - Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. AU - Tang, Yang. AU - Lu, Aigang. AU - Aronow, Bruce J.. AU - Wagner, Kenneth R.. AU - Sharp, Frank R. PY - 2002. Y1 - 2002. N2 - RNA expression profiles in rat brain were examined 24 h after ischemic stroke, intracerebral haemorrhage, kainate-induced seizures, insulin-induced hypoglycemia, and hypoxia and compared to sham- or untouched controls. Rat oligonucleotide microarrays were used to compare expression of over 8000 transcripts from three subjects in each group (n = 27). Of the somewhat less than 4000 transcripts called present in normal or treated cortex, 5-10% of these were up-regulated 24 h after ischemia (415), haemorrhage (205), kainate (187), and hypoglycemia (302) with relatively few genes induced by 6 h of moderate (8% oxygen) hypoxia (15). Of the genes induced 24 h after ischemia, haemorrhage, and hypoglycemia, approximately half were unique ...
OBJECTIVE: To perform a systematic review and pooled meta-analysis of published studies to assess whether the presence of leukoaraiosis on neuroimaging before treatment with thrombolysis (IV or intra-arterial) is associated with an increased risk of symptomatic intracerebral hemorrhage (sICH) or poor functional outcome. METHODS: We included studies of patients with acute ischemic stroke, treated with IV or intra-arterial thrombolysis, which assessed functional outcome (3-month modified Rankin Scale [mRS]) or sICH in relation to leukoaraiosis on pretreatment neuroimaging (CT or MRI). We used random-effects models to calculate pooled relative risks (RR) of sICH and poor functional outcome (mRS ≥ 2) for any vs no leukoaraiosis (using any rating scale) and for no to mild vs moderate to severe leukoaraiosis (using the Van Swieten or Fazekas Schmidt scale). RESULTS: We identified 15 studies (total n = 6,967). For sICH outcome, the RR was 1.65 (n = 5,551; 95% confidence interval [CI] 1.26-2.16, p = 0.001)
NLRP6 inflammasome, one of the important intracellular innate immune sensors, has been shown to regulate immune responses. However, its roles in the intracerebral hemorrhage (ICH) are completely not clear. In the present study, we investigated the expression profile and biological roles of NLRP6 inflammasome in perihematomal brain tissues of mice subjected to ICH. In this study, we investigated the expression profile of NLRP6 inflammasome in the perihematomal brain tissues and explored the biological role of NLRP6 inflammasome upon acute brain injury in mice subjected to ICH. Increased expression of NLRP6 inflammasome was found in perihematomal brain tissues ranging from 6 h to 3 days, with a peak level at 1 day after ICH. Immunohistochemistry staining also showed that NLRP6 inflammasome was significantly increased in the perihematomal brain tissues at 1 day after ICH. Moreover, immunofluorescence staining showed that NLRP6 inflammasome was mainly colocalized in glial fibrillary acidic protein ...
TY - JOUR. T1 - The presence of multiple microbleeds as a predictor of subsequent cerebral hemorrhage in patients with moyamoya disease - Commentary. AU - Komotar, Ricardo J.. AU - Connolly, E. Sander. PY - 2008/1/1. Y1 - 2008/1/1. UR - http://www.scopus.com/inward/record.url?scp=43149121806&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=43149121806&partnerID=8YFLogxK. U2 - 10.1227/01.NEU.0000311067.41239.E6. DO - 10.1227/01.NEU.0000311067.41239.E6. M3 - Comment/debate. AN - SCOPUS:43149121806. VL - 62. JO - Neurosurgery. JF - Neurosurgery. SN - 0148-396X. IS - 1. ER - ...
TY - JOUR. T1 - Surgery for intracerebral hematoma. T2 - The search for the elusive right candidate. AU - Rabinstein, Alejandro A.. AU - Wijdicks, Eelco F.M.. PY - 2006/9/1. Y1 - 2006/9/1. N2 - The value of surgery for patients with intracerebral hemorrhage (ICH) remains a topic of debate. Although several studies have been unable to prove the benefit of surgical intervention of ICH, there is available evidence to suggest that some patients may experience favorable outcome with surgery. Identifying optimal candidates and the timing of surgery for the treatment of ICH are crucial issues. Studies have explored the value of early and ultra-early surgical intervention, as well as the role of stereotactic hematoma evacuation. The International Surgical Trial in Intracerebral Hemorrhage suggested that favorable surgical outcome was more likely for patients with superficial hematomas, and patients who underwent craniotomy in the trial seemed to fare better than those treated with other surgical ...
A 50 years old female presented with hemorrhage in the brain secondary to a stroke. The cause of stroke is because of the heart valve surgery that was done when she was 16 years old. The artificial heart valve can cause some emboli and high blood pressure. Furthermore, she was in blood thinner that can make this hemorrhage worse. The brain hemorrhage occurred in the dominant side of the brain, the left side in the back where people understand, talk and read. She had difficulty in reading, writing, understanding and getting sleepy. She could not be off blood thinner for long. The brain hemorrhage can also be related to tumor. She was urgently taken to surgery; the hematoma was evacuated through the craniotomy and was sent for pathology. The bleeding was controlled and the patient went to intensive care unit and CT scan showed no more hemorrhage. Pathology showed no tumors. She required extensive speech therapy for one year to learn how to talk. Furthermore, when therapist and doctors told her ...
To test the hypothesis that acute hyotension resulting from pneumothorax would be associated with severe brain injury (grade 3 or 4 intraventricular haemorrhage), 67 very low birthweight (VLBW) infants of 32 weeks gestation or less with respiratory distress syndrom and pneumothorax were studies. Thirty six had pneumothorax associated with systemic hypotension and 31 had pneumothorax with normal blood pressure. The groups were similar in gestational age and severity of their respiratory distress syndrome. Thirty two of 36 of infants with pneumothorax associated with hypotension (89%) had grade 3 or 4 intraventricular haemorrhage. This percentage was significantly greater than the percentage for infants with pneumothorax and normal blood pressure (three of 31, 10%). The risk ratio for grade 3 or 4 intraventricular haemorrhage for infants with pneumothorax associated with hypotension was 9-8 compared with neonates with pneumothorax and normal blood pressure. These observations are consistent with ...
Background: Intraventricular hemorrhages and respiratory distress syndrome are two common diseases in preterm infants. Observation-based care, may reduce the rate of these complications through energy saving, diminishing apnea periods and cerebral blood flow changes. Aim: to evaluate the effect of behavior observation-based care training for mothers on intraventricular hemorrhages and ventilation period. Methods: In this two-group clinical trial, 70 infants with gestation age of less than 32 weeks were observed in neonate intensive care unit of Omolbanin Hospital, 2014. In the intervention group, the mothers and nurses received training in infant behavior and care program, and preterm infants behavior were observed and recorded by means of Assessment of Preterm Infants Behavior. At the end of the intervention, incidence of cerebral hemorrhage and the hours of ventilation were recorded. The data were analyzed performing independent t-test, Chi-square and Pearson correlation coefficient, using SPSS.
You might want to make curcumin part of your daily diet. This active ingredient of the Indian curry spice, turmeric, not only lowers your chances of getting cancer and Alzheimers disease, but may reduce the size of a hemorrhagic stroke, say Medical College of Georgia researchers. Second-year medical student Jay McCracken is working with Dr. Krishnan Dhandapani, neuroscientist in the MCG School of Medicine, using animal models to study curcumins effect on intracerebral hemorrhages, bleeding in the brain caused by ruptured vessels.
Results Mean follow-up duration was 10.7 years. Cut-off levels of Lp(a) for tertiles were 10 mg/dl and 23 mg/dl. Risks for all stroke were 1.34 (95% CI 1.03 to 1.74) and 1.00 (95% CI 0.77 to 1.31) in the lower and the higher Lp(a) group, respectively, with reference to the middle group after adjustment for age, smoking status, drinking status, systolic blood pressure, and body mass index. Risks for cerebral haemorrhage (lower tertile 2.25, 95% CI 1.28 to 3.94 and higher tertile 0.93, 95% CI 0.49 to 1.77), were similar to all stroke and no significant relationships were seen between Lp(a) and cerebral infarction (lower tertile 1.15, 95% CI 0.83 to 1.60 and higher tertile 1.02, 95% CI 0.74 to 1.41),or subarachnoid haemorrhage (lower tertile 1.04, 95% CI 0.52 to 2.09 and higher tertile 0.96, 95% CI 0.48 to 1.90). ...
He died May 27, 1948, from a cerebral hemorrhage and uremic poisoning and is interred at the Woodlands Cemetery in Philadelphia ... following a cerebral hemorrhage; in Syosset, N.Y. He founded the Drexel Biddle Bible Classes in 1907 (their curriculum of ...
He died of a cerebral hemorrhage in West Orange, New Jersey. New York Community Trust George W. Merck 1894 to 1957 Merck Forest ... George Wilhelm Merck, chairman of Merck Co., Inc., manufacturing chemists of Rahway, died today of a cerebral hemorrhage that ... of a cerebral hemorrhage; in West Orange, N.J. Devoted to company activities, with an exuberant capacity for work, Merck ...
Wilson died at age forty from a cerebral hemorrhage in New York City on January 16, 1989,[3][4] and was buried at Forest Park ...
A cerebral hemorrhage was suspected. The service was at West End Methodist Church. He was buried at Mt. Olivet Cemetery. Walker ...
11] Duranty, Walter (January 23, 1924). "Lenin Dies Of Cerebral Hemorrhage; Moscow Throngs Overcome With Grief; Trotsky Departs ...
"Cerebral Hemorrhage Fatal To Actress". The Knoxville Journal. Associated Press. July 3, 1955. Retrieved March 7, 2021 - via ... having died of a cerebral hemorrhage. Clark, ad-libbing, put his arm around Bonner and said "Ann, speak to me. Is something the ...
He died of cerebral hemorrhage. Orgocka started to work as a director right after school in the Andon Zako Çajupi theater of ...
Dies of a cerebral hemorrhage. (Paul Rosilli, 1981-82) Wants to steal the treasures of Malcuth. Hypnotizes Laura Spencer and ...
CORNELIUS VANDERBILT DEAD; Succumbed Suddenly Yesterday to Cerebral Hemorrhage. DUE TO STROKE OF PARALYSIS Wife and Daughter ...
He died of a cerebral hemorrhage. His wife of 52 years, Linda Ascher Singer survived him. They had three children together, ...
He died of a cerebral hemorrhage. The 1998 Chinese film Rhapsody of Spring directed by Teng Wenji is a slightly fictionalized ...
She died of a cerebral hemorrhage. Her death was described as "a national loss" by Mohamed Ould Abdel Aziz, the President of ...
Alice Vanderbilt's husband died of a cerebral hemorrhage on September 12, 1899, in their New York home at 1 West 57th Street. ... CORNELIUS VANDERBILT DEAD; Succumbed Suddenly Yesterday to Cerebral Hemorrhage. DUE TO STROKE OF PARALYSIS Wife and Daughter ... Great-Grandson and Namesake of Commodore Succumbs in Miami to Brain Hemorrhage. Family With Him At End. He Won Distinction as ...
"Aß is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis". Herzig MC, Winkler DT, ... "Cerebral hemorrhage following anti-Aß-immunotherapy". Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M ... "Peripherally applied Aß-containing inoculates induce cerebral ß-amyloidosis". Eisele YS, Obermueller U, Heilbronner G, Baumann ...
He died of a cerebral hemorrhage shortly after 6 a.m. on September 12, 1899, at his home, West Fifty-seventh Street, in ... CORNELIUS VANDERBILT DEAD; Succumbed Suddenly Yesterday to Cerebral Hemorrhage. DUE TO STROKE OF PARALYSIS Wife and Daughter ... Great-Grandson and Namesake of Commodore Succumbs in Miami to Brain Hemorrhage. Family With Him at End. He Won Distinction as ...
Then she dies from cerebral hemorrhage. Her brothers are in shock. They don't know what to do. Meanwhile, Fatma Hanim waits for ...
An autopsy revealed that he had died of a cerebral hemorrhage and that he also suffered from severe damage to his cerebral ... He had suffered a cerebral hemorrhage. He was moved onto a couch and remained there for three days. He was hand-fed using a ...
Cause of death cholelithiasis, cerebral hemorrhage. Randolph Thomas Edwards, known as Thomas R Edwards at the University of ...
He died of a cerebral hemorrhage. Japanese literature List of Japanese authors Fujioka, Takeo. Seimei no sakebi Ito Sachio. ...
Ebara is also remembered as the founder of Azabu High School (then a middle school). Ebara died of a cerebral hemorrhage. ...
Osman Durmuş, 73, Turkish politician, Minister of Health (1999-2002) and MP (1999-2002, 2007-2011), cerebral hemorrhage. Glenn ... Larry Questad, 77, American Olympic sprinter (1968). Arturo Rivera, 75, Mexican painter, cerebral hemorrhage. Travis Roy, 45, ... Ab Krook, 76, Dutch speed skating coach, cerebral infarction. Marisa de Leza, 87, Spanish actress (I'm Not Mata Hari, Under the ... dies at 77 Fallece el artista plástico Arturo Rivera de una hemorragia cerebral (in Spanish) Philanthropist and Former-Hockey ...
Jurjaan Koolen, 81, Dutch Olympic volleyball player (1964). Li Zhensheng, 79, Chinese photojournalist, cerebral hemorrhage. ...
He died suddenly of a cerebral hemorrhage. R. Yekusiel Zishe Heschel, second son of r. Moshe Mordechai, is the current ...
Masahisa Fukase, 78, Japanese photographer, cerebral hemorrhage. Paul Jenkins, 88, American abstract expressionist painter. ... Krishna Bhusan Bal, 64, Nepalese poet, intracerebral hemorrhage. Shigemitsu Dandō, 98, Japanese jurist and Supreme Court judge ...
In 1941, Lufei died of cerebral hemorrhage. [1] Lufei Kui Library at Tongxiang, Zhejiang 中国出版家陆费逵,周其厚,人民出版社,2016 (Chinese ...
He died from cerebral hemorrhage in 1972. Egasa Higasa (絵傘日傘, Graphic umbrella Sun umbrella) : 1933 Akagi no Komoriuta (赤城の子守唄 ...
Sorenson died of cerebral hemorrhage that day. Gunness explained he had come home with a headache and she provided him with ...
Rane Arroyo, 55, American poet, cerebral hemorrhage. Anders Buraas, 94, Norwegian journalist. Babz Chula, 64, American actress ... Hadi Soesastro, 65, Indonesian economist and intellectual, founder of the CSIS, brain hemorrhage. El Supremo, 67, Mexican ... Driek van Wissen, 66, Dutch poet, intracranial hemorrhage. Martin Gardner, 95, American mathematics and science author. Hasri ... Gary Coleman, 42, American actor (Diff'rent Strokes), intracranial hemorrhage. Sir Hugh Ford, 96, British engineer Ted Innes, ...
David Bowman, 54, American writer, cerebral hemorrhage. Rich Brenner, 65, American sports commentator. Pedro Azabache ...
Jean-Edern Hallier, 60, French writer, critic and editor, cerebral haemorrhage after fall. Jean Hoerni, 72, Swiss-American ... Theo Wilson, 79, American reporter, cerebral hemorrhage. Herbert A. Allen Sr., 88, American stockbroker. Ruth Brinkmann, 62, ...
In 1938 mother, Delia, suffered a stroke and died of cerebral hemorrhage three years later. Nitcholas died of stomach cancer in ...
... suffered a cerebral hemorrhage[8] on January 19, 2010, and slipped into a coma,[19] enduring bouts of blood clots, ...
Pages in category "Deaths from cerebral hemorrhage". The following 87 pages are in this category, out of 87 total. ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Category:Deaths_from_cerebral_hemorrhage&oldid=5744309" ...
Roosevelt died of a cerebral hemorrhage in April 1945, just months after the start of his fourth term. Soon after, Republicans ...
Blindness can occur in combination with such conditions as intellectual disability, autism spectrum disorders, cerebral palsy, ... That is, diabetic retinopathy describes the retinal and vitreous hemorrhages or retinal capillary blockage caused by the ...
Buddha died soon after from a cerebral hemorrhage.[8] Reception[edit]. Box office[edit]. Any Which Way You Can opened on ...
Barney died of a cerebral hemorrhage on February 25, 1969, at age 46; Betty Hill died of cancer on October 17, 2004, at age 85 ...
... and pulmonary hemorrhage (excess RBC's in the interstitium or alveoli can absorb CO and artificially increase the DLCO capacity ... Thoracic, abdominal, or cerebral aneurysms. *Cataracts or recent eye surgery. *Recent thoracic or abdominal surgery ...
... cancer and cerebral hemorrhage. Generally, the low cholesterol levels seem to be a consequence of an underlying illness, rather ...
... retinal hemorrhages, blurred vision, extension plantar reflexes, and ocular paralysis.[4] Cranial nerve palsies occur in some ... High-altitude cerebral oedema (HACO). High-altitude cerebral edema (HACE) is a medical condition in which the brain swells with ... If a lumbar puncture is performed, it will show normal cerebral spinal fluid and cell counts but an increase in pressure.[7] In ... Wilson, Mark; Newman, Stanton; Imray, Chris (2009). "The Cerebral Effects of Ascent to High Altitudes". Lancet Neurology. 8 (2 ...
Cerebral edema, brain hemorrhages and hydrocephalus exert pressure on brain tissue and impede their absorption of oxygen. ... diffuse cerebral hypoxia (DCH), focal cerebral ischemia, cerebral infarction, and global cerebral ischemia. Prolonged hypoxia ... Cerebral infarction - A "stroke", caused by complete oxygen deprivation due to an interference in cerebral blood flow which ... "Cerebral hypoxia". MedlinePlus Medical Encyclopedia. U.S. National Library of Medicine. 2007-04-05. Retrieved 2007-04-13.. ...
In the elderly population, amyloid angiopathy is associated with cerebral infarcts as well as hemorrhage in superficial ... This hemorrhage rarely extends into the ventricular system. Nontraumatic intraparenchymal hemorrhage most commonly results from ... The other form is intraventricular hemorrhage (IVH). Intraparenchymal hemorrhage accounts for approx. 8-13% of all strokes and ... Clinical manifestations of intraparenchymal hemorrhage are determined by the size and location of hemorrhage, but may include ...
The anterior cerebral artery forms the anterolateral portion of the circle of Willis, while the middle cerebral artery does not ... Main article: Subarachnoid haemorrhage. Subclavian steal syndrome[edit]. The redundancies that the circle of Willis introduce ... Cerebral angiogram showing an anterior/posterior projection of the vertebrobasilar and posterior cerebral circulation, the ... The circle of Willis (also called Willis' circle, loop of Willis, cerebral arterial circle, and Willis polygon) is a ...
... following a cerebral haemorrhage; philosopher Michel Foucault (from complications of AIDS) on 25 June 1984; Diana, Princess of ...
Montessori died of a cerebral hemorrhage on May 6, 1952 at the age of 81 in Noordwijk aan Zee, the Netherlands.[89] ...
1878). "The Goulstonian lectures of the localisation of cerebral disease. LectureI (concluded)". Br Med J. 1 (900): 443-7.. ... He seemed to be perfectly conscious, but was getting exhausted from the hemorrhage. His person, and the bed on which he was ... Barker, F.G.II (1995). "Phineas among the phrenologists: the American crowbar case and nineteenth-century theories of cerebral ... False-color representation of cerebral fiber pathways affected, per Van Horn et al.[22] ...
"The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid ... O Aβ cerebral está elevado en pacientes con enfermidade de Alzheimer esporádica. O Aβ é o principal constituínte do amiloide do ... Micrografía que mostra o amiloide beta (castaño) en placas senís do córtex cerebral (parte superior esquerda da imaxe) e vasos ... O amiloide beta pode ser principalmente vascular, como na anxiopatía amiloide cerebral, ou aparecer en placas senís e en vasos ...
The mother can lose blood and can have a haemorrhage; she may need a blood transfusion. placenta previa, where in the placenta ... and cerebral palsy. Recently the U.S. Public Health Service reported that if all pregnant women in the United States stopped ... There can also be complications, such as maternal hemorrhage. Some studies show that the probability of premature birth is ... weight babies face an increased risk of serious health problems as newborns have chronic lifelong disabilities such as cerebral ...
Bleeding from the ears and petechial hemorrhages in the skin also occurred."[193] The majority of deaths were from bacterial ... One observer wrote, "One of the most striking of the complications was hemorrhage from mucous membranes, especially from the ... Cerebral palsy. *Epilepsy (seizure disorders). *Stroke. *Intellectual disability. *Moderate to severe developmental delay ... pneumonia, a secondary infection caused by influenza, but the virus also killed people directly, causing massive hemorrhages ...
Tomás Carlovich, 74, Argentine footballer (Rosario Central, Central Córdoba, Independiente Rivadavia), cerebral hemorrhage ... cerebral hemorrhage.[178]. *Michael McCaskey, 76, American sports businessman, President of the Chicago Bears (1983-1999), ... Iran's OPEC governor dies after brain haemorrhage *↑ Former Bears President Michael McCaskey, Grandson of George Halas, Dies at ...
Stroke hemorragik terbagi menjadi subtipe intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH),[8] cerebral venous ... "Cerebral microbleeds: old leaks and new haemorrhages". Department of Neuroradiology, University Medical Centre Hamburg- ... cerebral embolism, intracerebral hematoma, subarachnoid hemorrhage dari malformasi aneurysm atau arteriovenous.[14] ... impaired cerebral autoregulation dan perubahan protrombotik dipercaya merupakan penyebab cerebral small vessel disease (SVD). ...
The brain and endocardium showed multiple petechial haemorrhages. The lungs had features consistent with acute respiratory ... There were important differences including the absence of coma despite petechial haemorrhages and parasite sequestration in the ...
... including cerebral Autoregulation and Cerebral Compliance).. Transcranial Doppler ultrasonography[edit]. The TCD measures the ... intracranial hemorrhage or stroke, liver failure, and climbers with acute mountain sickness. While the ONSD can at any given ... Cerebral ventricle[edit]. Michaeli [7] proposed that ICP be inferred from the magnitude and shape of pulsations of the third ... January 2003). "Adaptive noninvasive assessment of intracranial pressure and cerebral autoregulation". Stroke. 34 (1): 84-9. ...
Cerebral vasospasm may arise in the context of subarachnoid hemorrhage. Symptomatic vasospasm or delayed cerebral ischemia is a ... Vasospasm typically appears 4 to 10 days after subarachnoid hemorrhage. Along with physical resistance, vasospasm is a main ... major contributor to post-operative stroke and death especially after aneurysmal subarachnoid hemorrhage. ...
... , edema, is a severe and generalized edema with widespread subcutaneous tissue swelling.[1] It is usually caused by liver failure (cirrhosis of the liver), renal failure/disease, right-sided heart failure, as well as severe malnutrition/protein deficiency. The increase in salt and water retention caused by low cardiac output can also result in anasarca as a long term maladaptive response. It can also be created from the administration of exogenous intravenous fluid. Certain plant-derived anticancer chemotherapeutic agents, such as docetaxel, cause anasarca through a poorly understood capillary leak syndrome.[2] In Hb Barts, the high oxygen affinity results in poor oxygen delivery to peripheral tissues, resulting in anasarca. ...
... although effects of its deficiency on the development of hemorrhage and thrombosis appear to be limited. ...
... and/or subarachnoid or cerebral hemorrhage. Chest pain may occur due to increased workload on the heart resulting in a mismatch ... Some examples of neurological damage include hypertensive encephalopathy, cerebral vascular accident/cerebral infarction, ... is a manifestation of the dysfunction of cerebral autoregulation.[7] Cerebral autoregulation is the ability of the blood ... The eyes may show bleeding in the retina, an exudate, cotton-wool spots, scattered splinter hemorrhages, or swelling of the ...
Main article: cerebral hemorrhage. Intra-axial hemorrhage is bleeding within the brain itself, or cerebral hemorrhage. This ... Cerebral contusionEdit. Main article: Cerebral contusion. Cerebral contusion is bruising of the brain tissue. The piamater is ... Epidural hemorrhage (extradural hemorrhage) which occur between the dura mater (the outermost meninx) and the skull, is caused ... Types of intracranial hemorrhage are roughly grouped into intra-axial and extra-axial. The hemorrhage is considered a focal ...
Vascular: cerebral hemorrhage, stroke. *Infective: encephalitis, meningitis, brain abscess, spinal epidural abscess ... "Spastic Hemiplegia : Cerebral Palsy". OriginsOfCerebralPalsy.com. Retrieved 2013-03-08.. *^ [2] Archived October 11, 2010, at ... Traumatic: cerebral lacerations, subdural hematoma, epidural hematoma, vertebral compression fracture. *Iatrogenic: local ... Congenital: cerebral palsy, Neonatal-Onset Multisystem Inflammatory Disease (NOMID). *Degenerative: ALS, corticobasal ...
Cerebral hemorrhage. ശവകുടീരം. Forest Lawn Memorial Park, Glendale, California. ഭവനം. Pickfair, Beverly Hills, California, U.S. ...
Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
Initial tests indicated that the 61-year-old senator had experienced a cerebral hemorrhage. He has reported no serious health ... is listed in serious condition after four hours of surgery yesterday for a cerebral hemorrhage. ... The doctors were successful in accomplishing their objective and the hemorrhage has been stabilized, said Eryn Witcher, ...
encoded search term (What causes hemorrhage in cerebral amyloid angiopathy (CAA)?) and What causes hemorrhage in cerebral ... Drugs & Diseases , Neurology , Cerebral Amyloid Angiopathy Q&A What causes hemorrhage in cerebral amyloid angiopathy (CAA)?. ... Outcome of cerebral amyloid angiopathic brain haemorrhage. Acta Neurochir (Wien). 2008 Sep. 150(9):889-95. [Medline]. ... Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke. 2004 Jun. 35(6):1415-20. [Medline ...
Ambassador Harriman dead from cerebral hemorrhage. February 5, 1997. Web posted at: 10:21 a.m. EST (1521 GMT) PARIS (CNN) -- U. ... S. Ambassador to France Pamela Harriman died Wednesday two days after suffering a massive cerebral hemorrhage, an aide said. ...
It is expected to be used to develop biopharmaceutical for hemostasis of cerebral hemorrhage and brain tissue regeneration ... Brain hemorrhage, which can occur in the human brain, including intraventricular hemorrhage, intracerebral hemorrhage and ... Cerebral hemorrhage accounts for 10-15% of all stroke patients, and the mortality rate is 30-50% within 30 days of onset. ... Protein to stop acute cerebral hemorrhage Korean researchers have identified the mechanism of thermo-sensitive elastin-like ...
Definition of arteries of cerebral hemorrhage. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms ...
Bleeding in Cerebral Haemorrhage. Br Med J 1911; 1 doi: https://doi.org/10.1136/bmj.1.2621.727 (Published 25 March 1911) Cite ...
Predicting Intracerebral Hemorrhage Expansion With Noncontrast Computed TomographyThe BAT Score Andrea Morotti, Dar Dowlatshahi ... Childhood Stature and Growth in Relation to First Ischemic Stroke or Intracerebral Hemorrhage Line Klingen Gjærde, Thomas ... Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage Stroke. 2018;STROKEAHA.117.019541, originally ... Characteristics of Randomized Trials Focusing on Stroke due to Intracerebral HemorrhageSystematic Review Arina Tamborska, ...
Cerebral hemorrhage - Bleeding into the brain, is clearly explained in Medindia s glossary of medical terms ... Cerebral hemorrhage - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
Mario Zuccarello;] -- The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held ... "도서관에서 가져오기! Cerebral vasospasm : neurovascular events after subarachnoid hemorrhage. [ ... Cerebral vasospasm : neurovascular events after subarachnoid hemorrhage. 저자:. Mario Zuccarello. 출판사:. Vienna ; New York : ... schema:name "Cerebral vasospasm : neurovascular events after subarachnoid hemorrhage"@en ;. schema:productID "808368406" ;. ...
Mario Zuccarello;] -- The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held ... Cerebral vasospasm : neurovascular events after subarachnoid hemorrhage. Author:. Mario Zuccarello. Publisher:. Vienna ; New ... schema:name "Cerebral vasospasm : neurovascular events after subarachnoid hemorrhage"@en ;. schema:productID "808368406" ;. ... Global Cerebral Atrophy After Subarachnoid Hemorrhage: A Possible Marker of Acute Brain Injury and Assessment of Its Impact on ...
Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance.. Xu WH1, Li ML, Gao S, Ni J, Yao M, Zhou LX, ... Little is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. Using ... which are highly suggestive of fresh or recent intraplaque hemorrhage. ...
Intra Cerebral Hemorrhage Subarachnoid Hemorrhage Intraventricular Hemorrhage Nontraumatic Haemorrhage Show detailed ... Cerebral Hemorrhage. Brain Diseases. Subarachnoid Hemorrhage. Hemorrhage. Pathologic Processes. Intracranial Hemorrhages. ... subarachnoid hemorrhage, intracerebral hemorrhage, subdural hemorrhage, intraventricular hemorrhage), brain tumors, difficult ... Recovery After Cerebral Hemorrhage (REACH). The safety and scientific validity of this study is the responsibility of the study ...
... Vivek Mehta, Jonathan Russin, ... "Adoptive Regulatory T-cell Therapy Attenuates Subarachnoid Hemor-rhage-induced Cerebral Inflammation by Suppressing TLR4/NF-B ... matrix metalloproteinase-9 concentration in the first 48 h after aneurysmal subarachnoid haemorrhage predicts delayed cerebral ... "Immune cells subpopulations in cerebrospinal fluid and peripheral blood of patients with Aneurysmal Subarachnoid Hemorrhage," ...
... Chih-Lung Lin. ,1. ,. 2 Aaron S. Dumont. ... Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Mechanism and Therapies,. BioMed Research International,. vol. ... Although cerebral vasospasm (CV) after aneurysmal subarachnoid hemorrhage (SAH) has been recognized for more than half a ... D. A. Cook, "Mechanisms of cerebral vasospasm in subarachnoid haemorrhage," Pharmacology and Therapeutics, vol. 66, no. 2, pp. ...
... Cerebral hemorrhageClassification & external resources ICD-10 I60.-I62. ICD-9 430-431 DiseasesDB 29320 MeSH ... Intracranial hemorrhage/cerebral hemorrhage: Extra-axial hemorrhage (Epidural hemorrhage, Subdural hemorrhage, Subarachnoid ... A intracranial hemorrhage is a bleed into the substance of the cerebrum.[1] Cerebral hemorrhages can lead to hemorrhagic ... Symptoms of cerebral hemorrhage. A sudden, severe headache is common in hemorrhagic stroke, and is especially indicative of ...
... and computed tomographic features characteristic of moyamoya disease and a large intracerebral hemorrhage is presented. The ... Cerebral Hemorrhage / complications*, radiography. European Continental Ancestry Group. Humans. Male. Middle Aged. Moyamoya ... and computed tomographic features characteristic of moyamoya disease and a large intracerebral hemorrhage is presented. The ...
... the most lethal disorder of the cerebral circulation. ... Most SAH haemorrhages are the result of ruptured cerebral ... demonstrates that as little as half an hour of light exercise per week effectively protects against subarachnoid hemorrhage, ... Among disorders of the cerebral circulation, subarachnoid haemorrhage (SAH) is the most lethal kind, with as many as half of ... Exercise an effective protection against life-threatening cerebral hemorrhage. University of Helsinki ...
... By Malik. See all Articles by Usama MalikGet Updates ... If a bleed does occur there is little that medical practitioners can do to prevent a brain hemorrhage. Cerebral palsy may ... are responsible for about 90 percent of those affected by cerebral palsy (CP). Brain hemorrhage, meningitis, encephalitis, head ... Brain hemorrhage is caused by vulnerable premature babies because they are not able to regulate blood flow and just small ...
Hemorrhage, Phenobarbital, and Fluctuating Cerebral Blood Flow Velocity in the Neonate. Karl C. K. Kuban, Helen Skouteli, Allen ... Hemorrhage, Phenobarbital, and Fluctuating Cerebral Blood Flow Velocity in the Neonate. Karl C. K. Kuban, Helen Skouteli, Allen ... Hemorrhage, Phenobarbital, and Fluctuating Cerebral Blood Flow Velocity in the Neonate Message Subject (Your Name) has sent you ...
Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries.. Hansen-Schwartz J1, ... we investigated whether such changes occur in cerebral arteries in a rat subarachnoid hemorrhage (SAH) model. ... In the middle cerebral artery and basilar artery from rats with induced SAH, enhanced biphasic responses to ET-1 were observed ... After 2 days, the middle cerebral artery, basilar artery, and posterior communicating artery were harvested. Pharmacological ...
Hemorrhage. Cerebral Hemorrhage. Pathologic Processes. Intracranial Hemorrhages. Cerebrovascular Disorders. Brain Diseases. ... Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) investigators. Antihypertensive treatment of acute cerebral ... Antihypertensive Treatment of Acute Cerebral Hemorrhage-II (ATACH-II). The safety and scientific validity of this study is the ... Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. N Engl J Med. 2016 Sep 15;375(11):1033-43. doi: ...
UNILATERAL RETINAL CHANGES in CEREBRAL HÆMORRHAGE, EMBOLISM, and THROMBOSIS Br Med J 1898; 1 :1515 ... UNILATERAL RETINAL CHANGES in CEREBRAL HÆMORRHAGE, EMBOLISM, and THROMBOSIS. Br Med J 1898; 1 doi: https://doi.org/10.1136/bmj. ...
Make research projects and school reports about cerebral haemorrhage easy with credible articles from our FREE, online ... and pictures about cerebral haemorrhage at Encyclopedia.com. ... cerebral haemorrhage n. bleeding from a cerebral blood vessel ... cerebral haemorrhage Form of stroke in which there is bleeding from a blood vessel in the brain into the surrounding tissue. It ... cerebral haemorrhage A Dictionary of Nursing © A Dictionary of Nursing 2008, originally published by Oxford University Press ...
... dysfunction has been implicated in ischemic risk following aneurysmal subarachnoid hemorrhage (aSAH), but never directly imaged ... Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow ... Keywords: Delayed cerebral ischemia; aneurysm; blood-brain barrier; dynamic contrast-enhanced magnetic resonance imaging; ... Blood-brain barrier (BBB) dysfunction has been implicated in ischemic risk following aneurysmal subarachnoid hemorrhage (aSAH ...
Pages in category "Deaths from cerebral hemorrhage". The following 87 pages are in this category, out of 87 total. ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Category:Deaths_from_cerebral_hemorrhage&oldid=5744309" ...
The delayed cerebral vasoconstriction known as cerebral vasospasm remains a significant cause of permanent neurological deficit ... and death following aneurysmal subarachnoid hemorrhage despite the best current medical therapies. The mechanism of cerebr ... The delayed cerebral vasoconstriction known as cerebral vasospasm remains a significant cause of permanent neurological deficit ... The mechanism of cerebral vasospasm remains unknown. Several new drugs have been tested in animal models of subarachnoid ...
An apparatus for segmenting a cerebral hemorrhage site in a medical image of a head comprises a means for segmenting an ... and determining a cerebral hemorrhage site within the possible cerebral hemorrhage region. 2. A method of segmenting a cerebral ... The cerebral hemorrhage is segmented on the head X-ray CT image for the diagnosis and treatment of the cerebral hemorrhage. The ... then determines that the regions has the cerebral hemorrhage if index0,=20%, or that the region has not the cerebral hemorrhage ...
To investigate the effects of hUC-MSC treatment for cerebral hemorrhage sequela, 20 patients with cerebral hemorrhage will be ... Cerebral Hemorrhage Intervention ICMJE Biological: Human umbilical cord mesenchymal stem cells A single dose of 2×107 hUC-MSC ... Human Umbilical Cord Mesenchymal Stem Cell in Cerebral Hemorrhage Sequela. The safety and scientific validity of this study is ... Human Umbilical Cord Mesenchymal Stem Cell in Cerebral Hemorrhage Sequela Official Title ICMJE Human Umbilical Cord Mesenchymal ...
Includes mixing instructions and ingredients needed for Cerebral Hemorrhage #2. ... The best recipe for a Cerebral Hemorrhage #2 alcoholic mixed drink, containing Baileys, Strawberry schnapps and Grenadine. ... Comments on Cerebral Hemorrhage #2:. There arent any comments for Cerebral Hemorrhage #2 yet. Why not mix one up and be the ...
  • This collection of papers represents a cross-section of the enormous progress that has been made towards a thorough understanding and effective treatment of neurovascular events following aneurysmal subarachnoid hemorrhage, including cerebral vasospasm. (worldcat.org)
  • Identifying Patient Report Outcomes Relevant to Aneurysmal Subarachnoid Hemorrhage Follow-Up / Stuart Ross, Deepti Bhargava, Yahia Al-Tamimi, Tony Goddard and Alan Tennant, et al. (worldcat.org)
  • Although cerebral vasospasm (CV) after aneurysmal subarachnoid hemorrhage (SAH) has been recognized for more than half a century, its pathophysiologic mechanism remains elusive [ 1 ]. (hindawi.com)
  • Blood-brain barrier (BBB) dysfunction has been implicated in ischemic risk following aneurysmal subarachnoid hemorrhage (aSAH), but never directly imaged. (nih.gov)
  • Prevention of delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage. (biomedsearch.com)
  • The delayed cerebral vasoconstriction known as cerebral vasospasm remains a significant cause of permanent neurological deficit and death following aneurysmal subarachnoid hemorrhage despite the best current medical therapies. (biomedsearch.com)
  • Background and Purpose- Established predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage are large amounts of extravasated blood and poor clinical condition on admission. (ahajournals.org)
  • Delayed cerebral ischemia (DCI) is a major contributor to the high case fatality and morbidity of aneurysmal subarachnoid hemorrhage (SAH). (ahajournals.org)
  • Patients with aneurysmal subarachnoid hemorrhage (SAH) who experience delayed cerebral ischemia (DCI) have an increased risk of poor outcome. (nih.gov)
  • Cerebral infarction is a common complication of aneurysmal subarachnoid hemorrhage (SAH), but usually occurs several days after onset as a complication of vasospasm or aneurysm repair. (springer.com)
  • Medical complications of aneurysmal subarachnoid hemorrhage: a report of the multicenter, cooperative aneurysm study. (springer.com)
  • In the near future, these radiogenomic techniques may help improve quality of life and patient outcomes via patient-specific approaches to the treatment of unruptured cerebral aneurysms and personalized medical management of secondary processes following aneurysmal SAH. (frontiersin.org)
  • The delayed vasospasm after aneurysmal subarachnoid hemorrhage is the main cause of morbidity and mortality in the treatment of intracranial aneurysm. (koreamed.org)
  • We investigated the association of multisection CT angiography (MSCTA) and perfusion CT (PCT) for the characterization of vasospasm secondary to aneurysmal subarachnoid hemorrhage. (ajnr.org)
  • Introduction: Delayed cerebral ischemia (DCI) is a major cause of disability and death after aneurysmal subarachnoid hemorrhage. (uib.no)
  • Method: CVR was examined in 42 patients with aneurysmal subarachnoid hemorrhage and 37 patients treated for unruptured intracranial aneurysm, using acetazolamide test with transcranial Doppler monitoring of blood flow velocities. (uib.no)
  • Conclusion: Our findings support the hypothesis that impaired CVR may be an independent predictor of clinical deterioration due to DCI, and may assist in identifying patients at risk after aneurysmal subarachnoid hemorrhage. (uib.no)
  • Bøthun M, Haaland ØA, Moen G, Logallo N, Svendsen F, Thomassen L, Helland CA. Impaired cerebrovascular reactivity may predict delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. (uib.no)
  • A 61-year-old woman presented with aneurysmal subarachnoid hemorrhage (SAH) associated with multiple remote intracerebral hemorrhages (ICHs). (nii.ac.jp)
  • Delayed cerebral ischemia (DCI) is a recognized complication of aneurysmal subarachnoid hemorrhage (aSAH) that contributes to poor outcome. (cns.org)
  • This research explores clinical risk factors associated with delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage. (cns.org)
  • Connolly ES, Jr., Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al: Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association. (cns.org)
  • Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, et al: Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. (cns.org)
  • Fergusen S, Macdonald RL: Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage. (cns.org)
  • OBJECTIVE To investigate whether increased BMI was associated with delayed cerebral ischemia (DCI) and subsequent infarction after aneurysmal subarachnoid hemorrhage (aSAH). (deepdyve.com)
  • Minor trauma could theoretically cause a cerebral hemorrhage if there was a pre-existing aneurysmal weakness in the blood vessel wall. (healthtap.com)
  • Should endovascular therapy for cerebral vasospasm coincide with hypervolemic-hypertensive therapy (HT) in aneurysmal subarachnoid hemorrhage (SAH)? (biomedcentral.com)
  • For patients with SAH surviving the early phase, secondary ischemia (or delayed cerebral ischemia, DCI) is popularly considered as the leading determinant of poor clinical outcome. (hindawi.com)
  • We prospectively examined whether post-bleed day 4 dynamic contrast-enhanced magnetic resonance (DCE-MR) BBB permeability imaging could predict development of delayed cerebral ischemia (DCI). (nih.gov)
  • Conclusions- There is strong evidence that smoking is a predictor of delayed cerebral ischemia. (ahajournals.org)
  • Delayed cerebral ischemia is considered to be caused by vasospasm. (nih.gov)
  • Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited. (springer.com)
  • Delayed cerebral ischemia was identified in 32 (20.9%) patients. (cns.org)
  • de Rooij NK, Rinkel GJ, Dankbaar JW, Frijns CJ: Delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review of clinical, laboratory, and radiological predictors. (cns.org)
  • Increased Body Mass Index Associated With Reduced Risk of Delayed Cerebral Ischemia and. (deepdyve.com)
  • Cerebral hemorrhage accounts for 10-15% of all stroke patients, and the mortality rate is 30-50% within 30 days of onset. (eurekalert.org)
  • Life-threatening neurological illnesses cared for in the NCCU include massive stroke, bleeding in and around the brain (subarachnoid hemorrhage, intracerebral hemorrhage, subdural hemorrhage, intraventricular hemorrhage), brain tumors , difficult to control seizures, neurologic infections, nerve and muscle diseases (such as myasthenia gravis or Guillain-Barre Syndrome), and spinal cord disorders among others. (clinicaltrials.gov)
  • ICH has a mortality rate of 44 percent after 30 days, higher than ischemic stroke or even the very deadly subarachnoid hemorrhage (Liebeskind, 2004). (bionity.com)
  • Selected patients with subarachnoid hemorrhage due to a ruptured aneurysm require emergency surgery to "clip" the aneurysm off from the normal brain blood circulation, and they receive nimodipine , a drug shown to reduce incidence of vasospasm, a complication of this type of stroke. (bionity.com)
  • The report from a National Institute of Neurological Disorders and Stroke Workshop on priorities for clinical research in intracerebral hemorrhage (ICH) in December 2003 recommended clinical trials for evaluation of blood pressure (BP) management in acute ICH as a leading priority. (clinicaltrials.gov)
  • cerebral haemorrhage Form of stroke in which there is bleeding from a blood vessel in the brain into the surrounding tissue. (encyclopedia.com)
  • See also SUBARACHNOID HAEMORRHAGE , STROKE . (thefreedictionary.com)
  • Given the safety and pharmacokinetic profile of minocycline in intracerebral hemorrhage and promising data in the treatment of ischemic stroke, intravenous minocycline is an excellent candidate for a prehospital treatment trial. (ovid.com)
  • IV thrombolysis could benefit acute ischemic stroke patients with both baseline cerebral microbleeds and atrial myxoma. (frontiersin.org)
  • Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. (semanticscholar.org)
  • BACKGROUND Intracerebral hemorrhage is the least treatable form of stroke. (semanticscholar.org)
  • A cerebral hemorrhage, or bleeding in the brain tissue that often occurs alongside a hemorrhagic stroke, has a variety of symptoms that depend on the severity, where the bleeding is, and how much tissue is affected. (williamskherkher.com)
  • The cerebral ischemia that occur after a subarachnoid hemorrhage (SAH) often results in death or severe disability and is a significant cause of stroke. (lu.se)
  • Fibrin Clot Properties in Acute Stroke: What Differs Cerebral Hemorrhage From Cerebral Ischemia? (ovid.com)
  • Spontaneous intracerebral hemorrhage (ICH) accounts for approximately 10 to 30% of all acute cerebrovascular events, and it is the type of stroke associated with the highest rates of mortality and residual disability. (springer.com)
  • Nonmedical people recognize a cerebral hemorrhage under other names, such as a stroke, or a stroke of apoplexy. (usg.edu)
  • Very often people get a mild hemorrhage and recover and then maybe much later get a second, final stroke which kills. (usg.edu)
  • Background and Purpose- Several definitions have been proposed to distinguish clinically relevant from incidental cerebral hemorrhagic transformation after thrombolytic therapy for acute ischemic stroke. (medworm.com)
  • We investigated which definition best identifies cerebral hemorrhages that alter long-term functional outcome in the National Institute of Neurological Disorders and Stroke (NINDS) tissue-type plasminogen activator (tPA) trials. (medworm.com)
  • Abstract Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) in ischaemic stroke has been associated with neurotoxicity, blood brain barrier (BBB) disruption and intra-cerebral hemorrhage. (medworm.com)
  • The health loss from ischemic stroke and intracerebral hemorrhage: evidence from the North East Melbourne Stroke Incidence Study (NEMESIS). (ebscohost.com)
  • Bleeding in the brain, also known as cerebral hemorrhage , is a type of stroke. (schmidtlaw.com)
  • Intracerebral hemorrhage can be caused by brain trauma, or it can occur spontaneously in hemorrhagic stroke. (doctorbhatia.com)
  • We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral b-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. (docme.ru)
  • ANN NEUROL 2010;68:959-962 T he most serious complication of intravenous thrombolysis (recombinant tissue-type plasminogen activator [rt-PA]) in the treatment of acute stroke is intracranial hemorrhage. (docme.ru)
  • rt-PA-related hemorrhages were defined according to the European Cooperative Acute Stroke Study (ECASS) II classification. (docme.ru)
  • Hemorrhagic infarct (HI) is defined as small petechiae with no space-occupying effect.4,5 Symptomatic intracerebral hemorrhage is defined as PH associated with an increase of 4 points on the National Institutes of Health Stroke Score (NIHSS). (docme.ru)
  • Conclusion Lower Lp(a) was an independent risk factor for stroke, especially, for cerebral haemorrhage in the general population. (bmj.com)
  • Current management of intracerebral haemorrhage in China: a national, multi-centre, hospital register study. (ebscohost.com)
  • Background: We aimed to examine current practice of the management and secondary prevention of intracerebral haemorrhage (ICH) in China where the disease is more common than in Western populations. (ebscohost.com)
  • Non-traumatic intracerebral haemorrhage is a spontaneous bleeding into the brain tissue. (doctorbhatia.com)
  • The hypothesis is that intravenous infusion of sodium nitrite is safe and effective for the reversal of cerebral vasospasm after subarachnoid hemorrhage in patients with a cerebral aneurysm. (clinicaltrials.gov)
  • N.Morgan ) A reporter and news anchor who covered the Sandy Hook mass shooting hoax, has died of an apparent Cerebral Hemorrhage-Brain Aneurysm. (beforeitsnews.com)
  • Those patients fortunate enough to survive a presenting SAH and subsequent securing of their aneurysm must still face a spectrum of secondary sequelae, which can include cerebral vasospasm, delayed ischemia, seizures, cerebral edema, hydrocephalus, and endocrinologic and catecholamine-induced systemic dysfunction in cardiac, pulmonary, and renal systems. (frontiersin.org)
  • In unruptured cerebral aneurysms, treatment decisions are less clear and currently based solely on treating larger lesions, using rigid aneurysm size cutoffs generalized from recent studies that are the subject of ongoing controversy. (frontiersin.org)
  • 1 Intracranial arterial narrowing and impaired cerebral autoregulation can reduce CBF and cause signs of ischemia as early as 72 hours after aneurysm rupture. (ajnr.org)
  • I have been on plavix and asparin 4 months, SP cerebral aneurysm repair) this evening I fell hard on my low back(completely missed a chair ), i couldnt move for a few mins, really hurt. (patientsville.com)
  • She had undergone microsurgical neck clipping for ruptured right middle cerebral artery aneurysm and ventriculo-peritoneal shunting 16 years previously. (nii.ac.jp)
  • An exploratory analysis was performed on 156 aSAH patients enrolled in the Cerebral Aneurysm Renin Angiotensin System (CARAS) study. (cns.org)
  • OBJECTIVE: To investigate the relationship between cognitive impairment and 1H magnetic resonance spectroscopy (1H MR spectroscopy) in patients with subarachnoid hemorrhage (SAH) caused by rupture of middle cerebral artery (MCA) aneurysm. (koreamed.org)
  • Of those, 156 (29%) received HT therapy, for clinically neurologic deficits attributable to cerebral vasospasm, after surgical aneurysm repair. (biomedcentral.com)
  • The frequency, causes, and clinical impact of acute infarction associated with the primary hemorrhage are poorly understood. (springer.com)
  • We evaluated the presence of cerebral infarction on admission CT in 487 patients admitted within 3 days of SAH onset to our center between July 1996 and September 2002. (springer.com)
  • 0.001), coma on presentation ( P = 0.001), intraventricular hemorrhage ( P = 0.002), elevated APACHE-II physiological subscores ( P = 0.026) and loss of consciousness at onset ( P = 0.029) were associated with early cerebral infarction. (springer.com)
  • Mortality ( P = 0.003) and death or moderate-to-severe disability (mRS 4-6, P = 0.01) occurred more frequently in the early cerebral infarction group. (springer.com)
  • Early cerebral infarction on CT is a rare but devastating complication of acute SAH. (springer.com)
  • The presumptive diagnosis of acute left middle cerebral artery (MCA) infarction was made. (frontiersin.org)
  • PCT can thus be used to assess cerebral ischemia and infarction as a result of vasospasm after SAH. (ajnr.org)
  • The pathogenesis of such bleeds is incompletely understood, but may relate to localised intra-vascular coagulation following trauma, localised infarction and necrosis, subsequent fibrinolysis and gradual haemorrhage formation. (forensicmed.co.uk)
  • As the incidence of cerebral infarction was determined by review of postoperative computed tomographic (CT) images, patients who were not evaluated with postoperative CT imaging were excluded from analysis (n = 9), leaving a total of 161 patients. (deepdyve.com)
  • Outcomes of Interest The primary outcomes of interest were the incidence of DCI and delayed cerebral infarction. (deepdyve.com)
  • DCI was defined as delayed neurological deterioration after aSAH not due to other causes evident on clinical, laboratory, or radiographic evaluation, as previously described.17 Delayed cerebral infarction was defined as a cerebral hypodensity in an arterial distribution visualized on CT imaging. (deepdyve.com)
  • Brain hemorrhage, which can occur in the human brain, including intraventricular hemorrhage, intracerebral hemorrhage and subarachnoid hemorrhage, is known to be a brain disease that causes permanent disability, such as paralysis or language disorder, or results in a high mortality rate. (eurekalert.org)
  • A third of intracerebral bleeds result in intraventricular haemorrhage, or bleeding within the brain's ventricles (Liebeskind, 2004). (bionity.com)
  • The observed associations with coma, global cerebral edema, intraventricular hemorrhage, and loss of consciousness at onset suggest that intracranial circulatory arrest may play a role in the pathogenesis of this disorder. (springer.com)
  • intraparenchymal hemorrhage and intraventricular hemorrhages. (doctorbhatia.com)
  • Intracerebral hemorrhage is common in persons with this condition, but pure subarachnoid or subdural hemorrhage is rarely seen. (lancs.ac.uk)
  • June 26, 2014 - A lawsuit (PDF) has been filed on behalf of a man who took Xarelto for atrial fibrillation and died six month later from uncontrollable bleeding in the brain (subdural hemorrhage). (schmidtlaw.com)
  • A report published in the Journal of Neurosurgery detailed the death of an 83 year-old Pradaxa patient who died of a cerebral hemorrhage after a minor fall . (schmidtlaw.com)
  • CAA-related brain changes include lobar cerebral and cerebellar hemorrhage, leukoencephalopathy, small cortical ischemic infarcts, and plaque deposition. (medscape.com)
  • Bilateral cerebellar hemorrhage occurred after thrombolysis, and a median suboccipital craniectomy and hematoma removal was performed. (frontiersin.org)
  • Diffuse cerebral and cerebellar volume loss within normal limits for patient of this age. (radiopaedia.org)
  • The effect of cerebellar haemorrhage (CBH) on the microstructure of the cerebellar-cerebral circuit is largely unexplored. (figshare.com)
  • The disruption of the cerebellar-cerebral microstructure at multiple sites adds further support for the concept of developmental diaschisis, which is propagated as an explanation for the consequences of early cerebellar injury on cognitive and affective domains. (figshare.com)
  • Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study. (bioportfolio.com)
  • Patients with spontaneous intracerebral hemorrhage (ICH) are predisposed to venous thromboembolic (VTE) complications, such as deep vein thrombosis and pulmonary embolism. (bioportfolio.com)
  • Pathological investigations have found accumulations of peri-venous plasma and blood suggesting that excessive cerebral venous pressure has disrupted vessels, initiating the intra-ventricular bleeding observed. (omicsonline.org)
  • This has led to unsuccessful searches for evidence of A-V shunts within the developing cerebrum, or loss of auto regulation in arterioles, producing excessive cerebral venous hypertension . (omicsonline.org)
  • Forcing increasing cerebral flow through inadequate venous vasculature requires increasing cerebral venous pressure. (omicsonline.org)
  • However, if rising cerebral pressure is insufficient to cause damage at birth, the infant may survive with a chronically high cerebral venous pressure . (omicsonline.org)
  • Neonatal intra-ventricular haemorrhage is typically highly asymmetrical, and a typical inappropriate venous pattern is described. (omicsonline.org)
  • A very small proportion is due to cerebral venous sinus thrombosis. (doctorbhatia.com)
  • Cerebral venous thrombosis (CVT) is the occlusion/thrombosis of the veins and/or venous sinuses in the brain [19]. (termedia.pl)
  • Cerebral venous thrombosis was first described in 1825 [20]. (termedia.pl)
  • Cerebral venous thrombosis can be difficult to diagnose because of the wide spectrum of clinical manifestations, so it requires a high index of suspicion [3,15,23]. (termedia.pl)
  • Cerebral venous thrombosis is a potentially serious, but treatable condition, and its outcome depends on early diagnosis and management. (termedia.pl)
  • Abstract Apoptosis in the endothelium of major cerebral arteries may play a role in the initiation and maintenance of cerebral vasospasm after subarachnoid hemorrhage (SAH). (omicsonline.org)
  • PhD, Lorenzo Rinaldo, MD,;MD, Alejandro A Rabinstein,;MD, Giuseppe Lanzino, 2018-04-04 00:00:00 Abstract BACKGROUND Increased body mass index (BMI) may be protective against cerebral ischemia in certain clinical contexts. (deepdyve.com)
  • 2007 . Inhibition of cerebrovascular raf activation reduces late cerebral ischemia after subarachnoid hemorrhage. (lu.se)
  • Treatment decisions are motivated by a desire to prevent rupture and the devastating morbidity and mortality associated with resulting subarachnoid hemorrhage (SAH). (frontiersin.org)
  • Cerebral vasospasm is a major cause of delayed neurologic morbidity after a subarachnoid hemorrhage (SAH). (ajnr.org)
  • The high rate of morbidity and mortality associated with intracerebral hemorrhage has prompted investigations for new medical and surgical therapies. (analyzedirect.com)
  • In patients suffering from SAH, cerebral vasospasm is a major cause of morbidity and mortality from multifocal cerebral infaretion. (biomedcentral.com)
  • However, there are no effective hemostatic methods or therapies to stop bleeding within the first 6 hours of acute intracerebral hemorrhage. (eurekalert.org)
  • Methods- We searched MEDLINE (1960-2012) for clinical, laboratory, and radiological predictors routinely available within 72 hours after subarachnoid hemorrhage. (ahajournals.org)
  • Recently, the existence of two types of amyloid proteins related to cerebral amyloid angiopathy, beta protein and cystatin C, has been reported, and immunohistochemical methods using antisera to these proteins have become available. (lancs.ac.uk)
  • Methods- We analyzed 4 candidate hemorrhage definitions for which the NINDS tPA trials public data set had relevant data. (medworm.com)
  • Methods: Sixty-nine patients with hypertensive cerebral hemorrhage were randomly divided into the observation group of 34 cases and the control group with 35 cases. (cnki.com.cn)
  • Clinical manifestations of cerebral amyloid angiopathy-related inflammation. (medscape.com)
  • Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. (medscape.com)
  • Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance. (nih.gov)
  • Little is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. (nih.gov)
  • A case with the clinical, x-ray, and computed tomographic features characteristic of moyamoya disease and a large intracerebral hemorrhage is presented. (biomedsearch.com)
  • There have been few clinical reports describing umbilical cord mesenchymal stem cells for treatment of cerebral hemorrhage. (clinicaltrials.gov)
  • Longstreth WT Jr., Nelson LM, Koepsell TD, van Belle G. Clinical course of spontaneous subarachnoid hemorrhage: a population-based study in King County, Washington. (springer.com)
  • Each kind of cerebral hemorrhage has distinctive clinical characteristics. (thefreedictionary.com)
  • Development of the clinical symptoms and /or signs of cerebral vasospasm and CT-angiography results warranting cerebral angiography. (clinicaltrials.gov)
  • The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. (semanticscholar.org)
  • The most common clinical presentation of cerebral aneurysms is rupture leading to subarachnoid hemorrhage (SAH) ( 2 ). (frontiersin.org)
  • We sought to determine whether MRI-based Cerebral Small Vessel Disease (CSVD) burden assessment, in addition to clinical and CT data, improved prediction of cognitive impairment after spontaneous Intracerebral Hemorrhage (ICH). (neurology.org)
  • Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation. (springer.com)
  • MR imaging: Multiple cortical-subcortical hematomas, which may be of varying ages and sizes, with no other clinical or radiologic cause of hemorrhage. (radiopaedia.org)
  • Personalized nursing care of cerebral hemorrhage patients can effectively reduce incidence of cerebral hemorrhage concurrent with hypostatic pneumonia, which is conducive to physical rehabilitation of patients and means significant implications in clinical practice. (alliedacademies.org)
  • Most SAH haemorrhages are the result of ruptured cerebral aneurysms, causing blood to flow from the largest cerebral arteries into the space between meninges, the membranes surrounding the brain, which increases intracranial pressure and reduces cerebral circulation. (eurekalert.org)
  • Many physicians have been reluctant to treat hypertension in these patients because of the concern that overaggressive treatment of blood pressure may decrease cerebral perfusion pressure, the difference between the mean arterial pressure and the intracranial pressure. (analyzedirect.com)
  • As with other types of hemorrhages within the skull, intraparenchymal bleeds are a serious medical emergency because they can increase intracranial pressure. (doctorbhatia.com)
  • Brain hemorrhage, meningitis, encephalitis, head injury causing a bleeding brain, hydrocephalus or kernicterus are responsible for most of the remaining ten percent of cases. (selfgrowth.com)
  • Brain hemorrhage is caused by vulnerable premature babies because they are not able to regulate blood flow and just small changes in blood pressure may cause a blood vessel to rupture. (selfgrowth.com)
  • If a bleed does occur there is little that medical practitioners can do to prevent a brain hemorrhage. (selfgrowth.com)
  • Cerebral palsy may result in some cases if the tissue is damaged either by the bleeding brain or by the increase in pressure within the brain caused by the brain hemorrhage. (selfgrowth.com)
  • Impact of medical complications on outcome after subarachnoid hemorrhage. (springer.com)
  • Ledezma CJ, Hoh BL, Carter BS, Pyror JC, Putman CM, Ogilvy CS (2006) Complications of cerebral arteriovenous malformation embolisation: multivariate analysis of predictive factors. (springer.com)
  • A person with a cerebral hemorrhage may have a sudden headache that is severe when lying down, changing positions, or by simply moving. (williamskherkher.com)
  • 17 Angiographic vasospasm has been demonstrated to decrease regional cerebral blood flow, particularly when a severe vasospasm (luminal reduction superior to 50%) is present. (ajnr.org)
  • Some years ago I took nexium for v. severe gerd, with haemorrhage. (patientsville.com)
  • Medical men say the hemorrhage which killed the President must have been very severe. (usg.edu)
  • Lawsuits have been filed by people who took Xarelto and developed severe bleeding in the brain (cerebral hemorrhage). (schmidtlaw.com)
  • Severe cerebral hemorrhage after minor trauma. (healthtap.com)
  • Brain bleed Neurology Abrupt bleeding into cerebral tissue, which may be 2º to HTN, ASHD malformations or trauma. (thefreedictionary.com)
  • Intra-cerebral haemorrhages may be superficial (in association with contusions) or deep-seated (usually within the basal ganglia). (forensicmed.co.uk)
  • Intra-cerebral haemorrhages may be primary (i.e. occurring at the time of the trauma) or secondary, due to the effects of raised intra-cranial pressure and cerebral oedema. (forensicmed.co.uk)
  • When an intra-cerebral haemorrhage has been caused by natural disease (such as systemic hypertension, for example), the haemorrhage is usually single, and located in the deep grey matter (e.g. thalamus), pons or cerebellum. (forensicmed.co.uk)
  • 2007 . Protein kinase C inhibition prevents upregulation of ETB and 5-HT1B receptors and reverses cerebral blood flow reduction in subarachnoid hemorrhage in rats. (lu.se)
  • Thermo-responsive elastin-like polypeptides can be used for the treatment of intracerebral hemorrhage including hypertensive cerebral hemorrhage, Willis' arterial ring obstruction (Moyamoya disease) and other particular cerebral hemorrhage. (eurekalert.org)
  • These results suggest that blood pressure management may be considered a safe strategy for the treatment of intracerebral hemorrhage. (analyzedirect.com)
  • Subarachnoid hemorrhage (SAH) is often accompanied by cerebral vasospasm (CVS), which is the phenomenon of narrowing of large cerebral arteries, and then can produce delayed ischemic neurological deficit (DIND) such as lateralized sensory dysfunction. (spiedigitallibrary.org)
  • Hereditary cerebral hemorrhage with amyloidosis (HCHWA) is a neurological condition in which an abnormal protein ( amyloid ) builds up in the walls of the arteries of the brain (and less frequently, veins). (nih.gov)
  • Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage. (springer.com)
  • It is of interest to clinicians who wish to apply state-of-the-art knowledge to their management of this devastating condition and to basic scientists wishing to expand their understanding of cerebrovascular and neural pathophysiology related to subarachnoid hemorrhage. (worldcat.org)
  • Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. (medscape.com)
  • Lobar hemorrhage in a elderly individual is most frequently due to cerebral amyloid angiopathy , especially if no obvious underlying mass can be identified on CT. (radiopaedia.org)
  • Pre-thrombolysis brain magnetic resonance imaging revealed extensive strictly lobar cerebral microbleeding (CMB). (nii.ac.jp)
  • We employed three validated CSVD burden scores: global, cerebral amyloid angiopathy (CAA)-specific, hypertensive arteriopathy (HTNA)-specific. (neurology.org)
  • Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome. (springer.com)
  • Stapf C, Mast H, Sciacca RR et al (2006) Predictors of hemorrhage in patients with untreated brain arteriovenous malformations. (springer.com)
  • The principal researcher Won Bae Jeon states "While there is no proper treatment to stop bleeding in the early stage of acute intracerebral hemorrhage, this study suggests the possibility of developing hemostatic therapies using thermo-responsive elastin-like polypeptide proteins. (eurekalert.org)
  • Bleeding in Cerebral. (bmj.com)
  • Cerebral arteriography may be used to determine the cause for bleeding, since some causes may be surgically corrected to reduce the risk of future bleeding. (bionity.com)
  • One of the most common risks is that the immature blood vessels which are very fragile in premature babies will rupture and result in a bleeding brain and that the resulting damage to the tissues will cause cerebral palsy. (selfgrowth.com)
  • cerebral haemorrhage n. bleeding from a cerebral blood vessel into the tissue of the brain. (encyclopedia.com)
  • bleeding within the cerebral hemispheres of the brain . (thefreedictionary.com)
  • A person who has cerebral bleeding may also experience communication difficulties and motor skill difficulties in which body parts may become weak and difficult to move. (williamskherkher.com)
  • President Roosevelt died from what doctors call a cerebral hemorrhage, which means a sudden extensive bleeding in the brain due to a ruptured blood vessel. (usg.edu)
  • If you or somebody you know was injured by cerebral hemorrhage (bleeding in the brain), you should contact our lawyers immediately for a free case consultation . (schmidtlaw.com)
  • An Intra-ventricular Haemorrhage (IVH) is a bleeding into the brain's ventricular system. (omicsonline.org)
  • Intra-ventricular haemorrhage (IVH) is a bleeding from these vessels, through the ventricle wall, into the fluid contained in the ventricular system. (omicsonline.org)
  • The two research teams used laboratory rats and artificially induce intracerebral hemorrhage. (eurekalert.org)
  • In the middle cerebral artery and basilar artery from rats with induced SAH, enhanced biphasic responses to ET-1 were observed. (nih.gov)
  • Fifty male Wistar and 40 GK rats (270-305 g) underwent 3 h of middle cerebral artery occlusion followed by reperfusion for 21 h. (aspetjournals.org)
  • Chalela JA, Kang DW, Warach S. Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state. (medscape.com)
  • Anatomical distribution of cerebral microbleeds and intracerebral hemorrhage in vertebrobasilar dolichoectasia. (bioportfolio.com)
  • Both cerebral microbleeds and cardiac myxoma may increase the risk of intracerebral hemorrhage after intravenous (IV) thrombolysis. (frontiersin.org)
  • We report a case of multiple cerebral microbleeds treated with IV thrombolysis with later findings of cardiac myxoma. (frontiersin.org)
  • Previous magnetic resonance imaging showed multiple cerebral microbleeds. (frontiersin.org)
  • Cerebral microbleeds may be associated with atrial myxoma. (frontiersin.org)
  • We report a patient with multiple cerebral microbleeds who was treated with thrombolysis and was later found to have cardiac myxoma. (frontiersin.org)
  • Using the new approach the authors have observed musical murmurs of pure tone quality in 15 patients with increased flow velocities in the cerebral arteries after spontaneous subarachnoid hemorrhage (SAH). (thejns.org)
  • interventions A computed tomography scan may be performed to locate the lesion and to differentiate the hemorrhage from an embolus or thrombus, or cerebral angiography may be used for these purposes. (thefreedictionary.com)
  • Post-thrombolytic computed tomography revealed asymptomatic multiple intracerebral hemorrhaging (ICH). (nii.ac.jp)
  • In patients with CVT, the incidence of cerebral hemorrhage was reported to be about 37% and subarachnoid hemorrhage (SAH) was found in 1% of patients [2,3,5]. (termedia.pl)
  • To investigate the effects of hUC-MSC treatment for cerebral hemorrhage sequela, 20 patients with cerebral hemorrhage will be enrolled and receive 4 times of hUC-MSC transplantation. (clinicaltrials.gov)
  • Methylene-tetrahydrofolate reductase gene polymorphisms in patients with cerebral hemorrhage. (ajtmh.org)
  • Cerebral Palsy may be avoided if diagnosis and treatment take place as soon as possible after the bleed. (selfgrowth.com)
  • Subarachnoid haemorrhage: diagnosis, causes and management. (springer.com)
  • Cerebral digital subtraction angiographies will be reviewed at at least 2 time points, including at the time of diagnosis of angiographic vasospasm immediately before treatment with nitrite and after up to 180 minutes of nitrite infusion. (clinicaltrials.gov)
  • 14 , 15 Multisection CT angiography (MSCTA) has recently emerged as a reliable and accurate method for the anatomic depiction of intracranial vessels 16 and offers the potential for the rapid diagnosis and monitoring of cerebral vasospasm. (ajnr.org)
  • His age, CMB topography, and decreased cerebral spinal fluid amyloid-β 40 and 42 levels were compatible with a diagnosis of cerebral amyloid angiopathy (CAA). (nii.ac.jp)
  • Inspired by organ culture-induced changes in the vascular endothelin (ET) receptor population, we investigated whether such changes occur in cerebral arteries in a rat subarachnoid hemorrhage (SAH) model. (nih.gov)
  • Most cerebral hemorrhages occur in the region of the basal ganglia and are caused by the rupture of a sclerotic artery as a result of hypertension. (thefreedictionary.com)
  • Recurrence of the condition has to be accounted for with the realization that should a hemorrhage occur underwater, the risks are very high for death from drowning. (scuba-doc.com)
  • Most intra-ventricular haemorrhages occur in the first 72 hours after birth. (omicsonline.org)
  • The other category of intracranial hemorrhage is extra-axial hemorrhage, such as epidural, subdural, and subarachnoid hematomas, which all occur within the skull but outside of the brain tissue. (doctorbhatia.com)
  • [3] This kind of hemorrhage can also occur in the cortex or subcortical areas, usually in the frontal or temporal lobes when due to head injury, and sometimes in the cerebellum. (doctorbhatia.com)
  • Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. (omicsonline.org)
  • The max-intracerebral hemorrhage score predicts long-term outcome of intracerebral hemorrhage. (bioportfolio.com)
  • Heart rate variability is associated with outcome in spontaneous intracerebral hemorrhage. (bioportfolio.com)
  • Dhar R, Diringer MN: The burden of the systemic inflammatory response predicts vasospasm and outcome after subarachnoid hemorrhage. (cns.org)
  • Among 27 patients with symptomatic cerebrovascular vasospasm investigated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. (ajnr.org)
  • The main findings of this thesis, suggest that kinase inhibition is a novel target for treatment of cerebrovascular disorders such as cerebral ischemia after SAH. (lu.se)
  • Cerebrovascular integrity was characterized by quantifying the occurrence of microinfarcts and haemorrhages and compared with wild-type mice without Aβ. (portlandpress.com)
  • After 2 days, the middle cerebral artery, basilar artery, and posterior communicating artery were harvested. (nih.gov)
  • Intracerebral hemorrhage , or ICH, accounts for 10 to 15 percent of all strokes (Weibers 2001). (bionity.com)
  • The phenomenon of delayed traumatic haemorrhage - identified in 1891 by Bollinger - is a relatively rare event. (forensicmed.co.uk)
  • Traumatic brain injuries are one of the most common causes of a cerebral hemorrhage. (schmidtlaw.com)