Pathological conditions of intracranial ARTERIES supplying the CEREBRUM. These diseases often are due to abnormalities or pathological processes in the ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; and POSTERIOR CEREBRAL ARTERY.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
The arterial blood vessels supplying the CEREBRUM.
The region of the lower limb between the FOOT and the LEG.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.
A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
The inferior part of the lower extremity between the KNEE and the ANKLE.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
Radiography of the vascular system of the brain after injection of a contrast medium.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
Veins draining the cerebrum.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
Pathological conditions involving ARTERIES in the skull, such as arteries supplying the CEREBRUM, the CEREBELLUM, the BRAIN STEM, and associated structures. They include atherosclerotic, congenital, traumatic, infectious, inflammatory, and other pathological processes.
The main artery of the thigh, a continuation of the external iliac artery.
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Any one of five terminal digits of the vertebrate FOOT.
A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
The vessels carrying blood away from the heart.
Elements of limited time intervals, contributing to particular results or situations.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Operative procedures for the treatment of vascular disorders.
The flow of BLOOD through or around an organ or region of the body.
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Inflammation of the connective and adipose tissues surrounding the KIDNEY.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Plethysmographic determination in which the intensity of light reflected from the skin surface and the red cells below is measured to determine the blood volume of the respective area. There are two types, transmission and reflectance.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Radiography of blood vessels after injection of a contrast medium.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin.
Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS; INTERNAL CAPSULE; PUTAMEN; SEPTAL NUCLEI; GYRUS CINGULI; and surfaces of the FRONTAL LOBE and PARIETAL LOBE.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.
Act of listening for sounds within the body.
The creation and display of functional images showing where the blood flow reaches by following the distribution of tracers injected into the blood stream.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Techniques for measuring blood pressure.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Dominance of one cerebral hemisphere over the other in cerebral functions.
Inhaling and exhaling the smoke of burning TOBACCO.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.

Cerebral arterial lesions resulting from inflammatory emboli. (1/277)

In order to study the effects of septic embolism on the brain, silicone rubber emboli of various types were injected into the carotid arteries of 35 dogs. Pathologic and angiographic studies were performed to assess the resultant arterial and parenchymal lesions. Pure silicone rubber emboli (14 dogs) produced occasional intra-arterial thrombosis but no arteritis. Sterile and bacterially contaminated emboli containing a lead-chromate pigment (similar to those used in previous studies of septic embolism) (11 dogs) and pure silicone rubber emboli with transversely oriented canals (10 dogs), after brief placement in a bacterial suspension, were associated with intense inflammatory arteritis. This was accompanied by focal meningitis, subarachnoid hemorrhage, thrombosis, and cerebritis of the underlying cortex. The findings resembled those found in mycotic aneurysm. Aneurysmal dilatation was observed in one postmortem angiogram. In previous models of mycotic aneurysm, the inflammation attributed to bacterial contamination was probably due to the lead-chromate pigment used.  (+info)

Epilepsy after two different neurosurgical approaches to the treatment of ruptured intracranial aneurysm. (2/277)

One-hundred-and-fifty-two patients who underwent surgery for intracranial aneurysm were studied to determine the incidence of postoperative epilepsy in relation to the site of the aneurysm and the type of surgical approach. The overall incidence of epilepsy was 22%. Of the 116 patients treated by the intracranial approach 27.5% developed epilepsy, in contrast with only 5% of the 36 patients who had carotid artery ligation in the neck. Epilepsy occurred most frequently (35%) with middle cerebral artery aneurysms, especially if moderate or severe operative trauma was sustained and there was postoperative dysphasia.  (+info)

Arterial spasm and recovery from subarachnoid haemorrhage. (3/277)

In a series of 120 cases of subarachnoid haemorrhage due to ruptured intracranial aneurysm the occurrence of preoperative arterial spasm was found to have no effect upon the clinical outcome. After surgery, generalised arterial spasm was found to lead to an increased probability of fatality, and to an increased probability of psychological impariment among the survivors. The occurrence of spasm only in the vessels immediately adjacent to the haemorrhage did not constitute a risk to survival. However, the presence of generalised or localised spasm led to an increased risk of neurological impairment. It is suggested that the mechanisms by which postoperative arterial spasm is responsible for fatalities and for neurological impairment are distinct.  (+info)

Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age. (4/277)

Although stroke in humans usually afflicts the elderly, most experimental studies on the nature of cerebral ischemia have used young animals. This is especially important when studying restorative processes that are age dependent. To explore the potential of older animals to initiate regenerative processes after cerebral ischemia, the authors studied the expression of the juvenile-specific cytoskeletal protein, microtubule-associated protein (MAP) 1B, and the adult-specific protein, MAP2, in male Sprague-Dawley rats at 3 months and 20 months of age. The levels of MAP1B and MAP2 transcripts and the corresponding proteins declined with increasing age in the hippocampus. In the cortex, the levels of the transcripts did not change significantly with age, but the morphologic features of immunostained fibers were clearly affected by age; that is, cortical MAP1B fibers became thicker, and MAP2 fibers, more diffuse, in aged rats. Focal cerebral ischemia, produced by reversible occlusion of the right middle cerebral artery, resulted in a large decrease in the expression of both MAP1B and MAP2 in the infarct core at the messenger ribonucleic acid and protein levels. However, at 1 week after the stroke, there was vigorous expression of MAP1B and its messenger ribonucleic acid, as well as MAP2 protein, in the border zone adjacent to the infarct of 3-month-old and 20 month-old male Sprague-Dawley rats. The upregulation of these key cytologic elements generally was diminished in aged rats compared with young animals, although the morphologic features of fibers in the infarct border zone were similar in both age groups. These results suggest that the regenerative potential of the aged rat brain appears to be competent, although attenuated, at least with respect to MAP1B and MAP2 expression up to 20 months of age.  (+info)

Transluminal angioplasty for middle cerebral artery stenosis in patients with acute ischemic stroke. (5/277)

BACKGROUND AND PURPOSE: Precutaneous transluminal angioplasty (PTA) is currently performed to treat supraaortic atherosclerotic lesions. Our purpose was to evaluate the safety and efficacy of PTA for middle cerebral artery (MCA) stenosis in patients with acute ischemic stroke. METHODS: We performed PTA with the use of a microballoon (2-2.5 mm in diameter and 10-13 mm in length) in 10 consecutive patients (mean age, 48 years) who met the following criteria: high-grade M1 stenosis (> 70%) and mild neurologic deficits (NIH stroke scale < 4) and/or recurrent transient ischemic attacks (TIAs) resistant to anticoagulation, or a large area of hypoperfusion in the MCA territory on brain perfusion SPECT scans. During follow-up, we administered antiplatelet agents and evaluated the status of restenosis by angiography (n = 2), brain perfusion SPECT (n = 4), and/or transcranial Doppler sonography (TCD) (n = 7). RESULTS: Stenotic arteries were successfully dilated in nine of 10 patients. Angioplasty failed in one patient because the balloon could not pass through the tortuous cavernous internal carotid artery. None of the patients experienced either peri- or postangioplasty complications. Residual stenosis was less than 50%, and clinical improvement, including elimination of TIAs in four patients who had suffered resistant TIAs, was observed in all patients; improvement of the cerebral perfusion was also noted in two patients with a large hypoperfusion area in the MCA territory. The average follow-up period was 11 months (range, 2 to 36 months). None experienced recurrent stroke during the follow-up period. TCD revealed decreased flow velocity of the MCA after angioplasty in seven patients. CONCLUSION: PTA of the proximal portion of the MCA seems to be a safe and effective therapeutic technique for the prevention of secondary ischemic stroke.  (+info)

Various patterns of perfusion-weighted MR imaging and MR angiographic findings in hyperacute ischemic stroke. (6/277)

BACKGROUND AND PURPOSE: Various clinical subtypes of patients presenting with sudden-onset ischemic stroke have been recognized, but classification of those types is not simple. We identified various patterns of perfusion-weighted MR imaging and MR angiographic findings in hyperacute ischemic stroke with relation to clinical outcomes. METHODS: Twelve patients with symptoms of acute ischemic stroke due to middle cerebral artery occlusion underwent perfusion-weighted MR imaging and MR angiography within 6 hours after the onset of symptoms. Perfusion-weighted imaging was performed with a conventional dynamic contrast-enhanced T2*-weighted sequence, and cerebral blood volume (CBV) maps were then created. CBV maps and MR angiographic findings were compared with 99mTc-HMPAO brain SPECT scans, short-term outcomes, and follow-up imaging findings. RESULTS: The combined CBV and MR angiographic findings were classified into three patterns: arterial occlusion and decreased CBV (n = 8), arterial occlusion and increased CBV (n = 2), and no arterial occlusion and normal CBV (n = 2). These three patterns were strongly related to SPECT findings, short-term outcomes, and follow-up imaging findings. Perfusion on SPECT decreased markedly in the affected regions in all patients with the first pattern, decreased slightly in the second pattern, and was normal in the third pattern. Symptoms were not significantly changed at 24 hours after onset in any of the patients with the first pattern, but resolved completely in all patients with the latter two patterns. Follow-up imaging showed large infarctions in all patients with the first pattern. Initially, no infarction was seen in the second pattern, but watershed infarction developed later in one of these patients. CONCLUSION: Hyperacute ischemic stroke may be differentiated into three imaging patterns with different clinical outcomes. The combined use of perfusion-weighted MR imaging and MR angiography may play a substantial role in guiding the choice of treatment of this disease.  (+info)

Carotid artery tandem lesions: frequency of angiographic detection and consequences for endarterectomy. (7/277)

BACKGROUND AND PURPOSE: Several prospective trials have shown that ischemic stroke can be prevented by performing an endarterectomy in patients with high-grade carotid stenosis. Our purpose was to ascertain the frequency of carotid artery tandem lesions and to determine whether their presence alters the surgeon's decision to perform an endarterectomy. METHODS: We retrospectively reviewed the cerebral angiograms obtained between January 1994 and June 1996 in 853 patients with carotid occlusive disease. Studies were analyzed for the presence of internal carotid artery (ICA) stenosis as well as for tandem lesions (defined as > or = 50% diameter stenosis) within the common carotid artery, carotid siphon, or proximal intracranial arteries. The frequency of intracranial saccular aneurysms was determined. RESULTS: Six hundred seventy-two of the 853 patients had a carotid bifurcation stenosis of 70% or greater or underwent an endarterectomy. Of these, a carotid siphon stenosis of 50% or greater was noted in 65 patients (9.7%) and was ipsilateral to an ICA stenosis in 37 patients (5.5%). A common carotid stenosis was present in 29 patients (4.3%), ipsilateral to an ICA stenosis in 14 patients (2.1%). A stenosis of 50% or greater within the proximal intracranial circulation was present in 28 patients (4.2%), ipsilateral to an ICA stenosis in 15 patients (2.2 %). Four patients had tandem stenoses at more than one site. Tandem stenoses in the siphon or intracranial segments were noted in 13.5% with a bifurcation stenosis and in 8.8% of those with no bifurcation stenosis. Endarterectomy was performed in 48 of the 66 patients with tandem stenotic lesions. CONCLUSION: The presence of a tandem lesion infrequently alters the surgeon's decision to perform an endarterectomy. However, the importance of detecting tandem stenoses cannot be underestimated, since they may have important implications for long-term medical management in symptomatic patients.  (+info)

Cerebral hemodynamics in relation to patterns of collateral flow. (8/277)

BACKGROUND AND PURPOSE: We sought to investigate the relation between collateral flow via different pathways and hemodynamic parameters measured by dynamic susceptibility contrast-enhanced MRI in patients with severe carotid artery disease. METHODS: Dynamic susceptibility contrast-enhanced MRI was performed in 66 patients and 33 control subjects. Patients had severe stenosis (>70%, n=12), unilateral occlusion (n=38), or bilateral occlusion (n=16) of the internal carotid artery (ICA). Cerebripetal flow and collateral flow via the circle of Willis were investigated with MR angiography. Collateral flow via the ophthalmic artery was investigated with transcranial Doppler sonography. RESULTS: Patients with ICA stenosis had well-preserved cerebral perfusion and were in general not dependent on collateral supply. Patients with unilateral ICA occlusion had impaired cerebral perfusion. However, appearance time, peak time, and mean transit time in white matter were less increased in patients with than in patients without collateral flow via the circle of Willis (P<0.05). Furthermore, patients with collateral flow via both anterior and posterior communicating arteries had less increased regional cerebral blood volume than patients with collateral flow via the posterior communicating artery only (P<0.05). Patients with bilateral ICA occlusion had severely compromised hemodynamic status despite recruitment of collateral supply. CONCLUSIONS: In patients with unilateral ICA occlusion, the pattern of collateral supply has significant influence on hemodynamic status. Collateral flow via the anterior communicating artery is a sign of well-preserved hemodynamic status, whereas no collateral flow via the circle of Willis or flow via only the posterior communicating artery is a sign of deteriorated cerebral perfusion.  (+info)

Until recently, cerebral arteriopathy due to heterozygous mutations of the ACTA2 gene was considered a variant of moyamoya disease. However, radiographic analysis of patients with these mutations reveals a distinctive angiographic appearance from that seen in moyamoya disease. Several heterozygous missense ACTA2 mutations have been implicated in the development of this distinct cerebrovascular entity; however, the penetrance and systemic manifestations of these mutations vary based on the location of the amino acid replacement within the α-smooth muscle actin protein. The severity of the phenotype may also differ among patients within a single mutation type. There is limited literature on the safety and efficacy of revascularization procedures for ACTA2 arteriopathy, which have been limited to those patients with known Arg179His mutations. The authors provide a review of the breadth of mutations within the ACTA2 literature and report a case of two siblings with de novo ACTA2 Arg258Cys mutations ...
Radiation therapy can cause cerebral arteriopahty, resulting in ischemic stroke. We document late-delayed cerebral arteriopathy by high-resolution magnetic resonance imaging (HR-MRI) in a middle aged man who had cranial irradiation 19 years earlier. A 45-year-old man was diagnosed with frontal lobe glioma 19 years ago and was treated with radiation after surgical resection. He was admitted to our hospital with an acute cerebral infarction in November 8, 2017. Traditional MRI examination and HR-MRI (sagittal, reconstruction of coronal and axial) were performed at admission. He was treated with prednisone (30 mg/day) and clinical symptoms disappeared after 3 months by telephone follow-up. Our patient complained of dizziness and blurred vision and traditional MRI examination indicated acute ischemic stroke in temporal lobe and occipital lobe and microbleeds. In order to define the exact mechanism of stroke, blood tests, auto-immune screening and thrombophilia were performed and results were normal.
Informasjon og diagnosebeskrivelsene er lenker til eksterne Internettsider.. En diagnose kan ha flere navn, både på norsk og de andre språkene. En liste over disse finner du på slutten av siden. ...
The instability of carotid and coronary plaques has been reported to be associated with acute coronary syndrome, strokes and other cerebrovascular events. Therefore, recognition of the tissue characteristics of carotid and coronary plaques is important to understand and prevent coronary and cerebral artery disease. Recently, an ultrasound integrated backscatter (IB) technique has been developed. The ultrasound IB power ratio is a function of the difference in acoustic characteristic impedance between the medium and target tissue, and the acoustic characteristic impedance is determined by the density of tissue multiplied by the speed of sound. This concept allows for tissue characterization of carotid and coronary plaques for risk stratification of patients with coronary and cerebral artery disease. Two- and three-dimensional IB color-coded maps for the evaluation of tissue components consist of four major components: fibrous, dense fibrosis, lipid pool and calcification. Although several ultrasound
ChILD: A Pictorial Review of Pulmonary Imaging Findings in Childhood Interstitial Lung Diseases. Verma N, Altmayer S, Hochhegger B, Barros MC, Rajderkar D, Mohammed TL. Curr Probl Diagn Radiol. 2020 April. PMID: 32317133 Dilated Cerebral Arteriopathy in Classical Pompe Disease: A Novel Finding. Viamonte M, Tuna I, Rees J. Pediatr Neurol. 2020 March. PMID: 32248988…
Metabolomics is a large-scale approach to monitoring as many as possible of the compounds involved in cellular processes in a single assay to derive metabolic profiles. Compared with genomics or proteomics, metabolomics reflects changes in phenotype and therefore function. Collection of exhaled breath condensate (EBC) is a newly developed, noninvasive method that may allow clinicians and researchers to assess biochemical profiles in the alveolar lining fluid. The aims of this study are: (1)Collecting and metabolomic profiling of the EBCs from patients with COPD/bronchiectasis; (2) Comparing the profiles of these patients obtained during stable and acute exacerbation periods; (3) Comparing the profiles of these patients with and without Pseudomonas colonization/infection; (4) Correlation of EBC metabolomic profiles with clinical phenotypes, severity and outcomes of these patients ...
TY - JOUR. T1 - Progression of isolated middle cerebral artery stenosis into moyamoya disease. AU - Choi, H. Y.. AU - Lee, J. E.. AU - Jung, Y. H.. AU - Cho, H. J.. AU - Kim, D. J.. AU - Heo, J. H.. PY - 2007/3. Y1 - 2007/3. UR - UR - U2 - 10.1212/01.wnl.0000244412.18039.03. DO - 10.1212/01.wnl.0000244412.18039.03. M3 - Comment/debate. C2 - 17372134. AN - SCOPUS:34147131170. VL - 68. SP - 954. JO - Neurology. JF - Neurology. SN - 0028-3878. IS - 12. ER - ...
This is the first case report of a CADASIL patient with MCA stenosis who underwent STA-MCA bypass to increase cerebral perfusion in the localized ischemic area. In CADASIL, reductions in both CBF and CVR occur in white matter showing T2-hyperintensity. It has been suggested that the degeneration of vascular smooth muscle cells causes arteriopathy, which leads to cerebral hypoperfusion and impaired autoregulation (Chabriat et al. 2000; Huang et al. 2010; Singhal and Markus 2005; van den Boom et al. 2003). Interestingly, the white-matter hyperintensity in the temporal lobe was found predominant in the left side in this case. This asymmetry of white-matter hyperintensity is very unusual rare in CADASIL, since it would suggest that these lesions do not originate from ischemia, but edema instead. The lower extent observed in the most hypoperfused temporal lobe further support that these lesions are not related to ischemia but mat actually result from edema with blood brain barrier dysfunction. ...
There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass surgery (CABG) or percutaneous coronary intervention. Perfusion defect on nuclear brain scan is also noted to correlate with these neurological complications. On the other hand, the perioperative arrhythmia and following cerebral embolism was also attributed to be one factor inducing such neurological hazards.. In the patients with coexistent CAD and CAS (1st group), and also the patients scheduled for CABG or percutaneous coronary intervention (PCI) (2nd group), we, the researchers at Far Eastern Memorial Hospital, attempted to integrate all the parameters mention above, including angiography of coronary and cerebral system, quantitative analysis of nuclear brain scan, biochemical profile, and signals of a new ambulatory device which could record the electrocardiograph ...
St. If plain radiographs show extensive involvement. It becomes important to reduce itching, thus. It is also possible and asthma should be obtained, in which inspired gas is characterized by rigid extension of the skin and in cases of invasive catheter placement, the skin. Benjamin hj, glow km strength training for children with painful hematuria should be protected from contact with strong cardiovascular effects owing to hypofib-rinogenemia, the goal of antibiotic resistance. A brain arteriovenous malformation arterial aneurysm carotid-cavernous fistula transient cerebral arteriopathy, arteriopathy associated with scleroderma can be postponed while awaiting susceptibility test results. American academy of pediatrics controversies concerning vitamin k at birth or acquired immunodeficiency syndrome cmv, cytomegalovirus csf, cerebrospinal fluid csf protein elevated within hours strongly consider hirschprungs disease. Connective tissue disease scleroderma, systemic lupus erythematosus, and viral ...
Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017 Nov; 38(11):2172-2179 ...
Ive been blessed with two generally pleasant children. When either of them is grumpy or impossible, its usually a sign that something is w...
TY - JOUR. T1 - Asymptomatic Distal Plaque Migration After Angioplasty of Atherosclerotic Middle Cerebral Artery Stenosis. AU - Dabus, Guilherme. AU - Bendok, Bernard R.. AU - Walker, Matthew T.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2013/1. Y1 - 2013/1. KW - Angioplasty. KW - Intracranial atherosclerotic disease. KW - Plaque. KW - Stenosis. UR - UR - U2 - 10.1111/j.1552-6569.2010.00522.x. DO - 10.1111/j.1552-6569.2010.00522.x. M3 - Letter. C2 - 20977530. AN - SCOPUS:84872549541. VL - 23. SP - 152. EP - 153. JO - Journal of Neuroimaging. JF - Journal of Neuroimaging. SN - 1051-2284. IS - 1. ER - ...
TY - JOUR. T1 - Sex-Dependent Differences in Physical Exercise-Mediated Cognitive Recovery Following Middle Cerebral Artery Occlusion in Aged Rats. AU - Cohan, Charles H.. AU - Youbi, Mehdi. AU - Saul, Isabel. AU - Ruiz, Alex A.. AU - Furones, Concepcion C.. AU - Patel, Pujan. AU - Perez, Edwin. AU - Raval, Ami P.. AU - Dave, Kunjan R.. AU - Zhao, Weizhao. AU - Dong, Chuanhui. AU - Rundek, Tatjana. AU - Koch, Sebastian. AU - Sacco, Ralph L.. AU - Perez-Pinzon, Miguel A.. PY - 2019/9/18. Y1 - 2019/9/18. N2 - Stroke remains a leading cause of death and disability in the United States. No current treatments exist to promote cognitive recovery in survivors of stroke. A previous study from our laboratory determined that an acute bout of forced treadmill exercise was able to promote cognitive recovery in 3 month old male rats after middle cerebral artery occlusion (MCAo). In this study, we tested the hypothesis that 6 days of intense acute bout of forced treadmill exercise (physical exercise - PE) ...
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541 ...
Authors: Allen, Rachael S. , Sayeed, Iqbal , Oumarbaeva, Yuliya , Morrison, Katherine C. , Choi, Paul H. , Pardue, Machelle T. , Stein, Donald G. Article Type: Research Article Abstract: Background/Objective: To determine whether inflammation increases in retina as it does in brain following middle cerebral artery occlusion (MCAO), and whether the neurosteroid progesterone, shown to have protective effects in both retina and brain after MCAO, reduces inflammation in retina as well as brain. Methods: MCAO rats treated systemically with progesterone or vehicle were compared with shams. Protein levels of cytosolic NF-κ B, nuclear NF-κ B, phosphorylated NF-κ B, IL-6, TNF-α, CD11b, progesterone receptor A and B, and pregnane X receptor were assessed in retinas and brains at 24 and 48 h using western blots. Results: …Following MCAO, significant increases were observed in the following inflammatory markers: pNF-κ B and CD11b at 24 h in both brain and retina, nuclear NF-κ B at 24 h in brain and ...
Specifying a User/RoleTemplate for a certain sync task all the not valued template attributes are translated into remove attribute requests. This cause an unjustified set of user attribute removes.. The wrong behavior is generated into ConnObjectUtil.fillFromTemplate method ...
The webs technology news site of record, Techmeme spotlights the hottest tech stories from all around the web on a single page.
Pre-made tests on Misery Mid-Book Test - Easy, including multiple choice, short answer, short essay, and in-depth essay questions.
About At the south-westernmost point of Walden Woods exists Mount Misery. This was a place Thoreau visited occasionally, where he paid much attention to the…
Стиль: Brutal Death Группа: Reincarnation Видео: The Streets Never Sleep (Клип) Альбом: The Beginning Of The End (2015) Год: 2015 С ...
Duckcore is the first with this EP. For an unknown band these guys make some pretty mean deathcore. Definitely worth a listen to ...
Reversible cerebral vasoconstriction syndrome (RCVS) is a fairly recently described constellation of clinical and radiological features: sudden, severe (thunderclap) headache; transient, multifocal, segmental vasoconstriction of cerebral arteries lasting several weeks to months; and focal neurological symptoms, sometimes with stroke. The features of what is now called RCVS have been repeatedly recognized, especially since an influential early report by Drs Call and Fleming et al1 published in 1988. A similar syndrome has attracted many different names, depending on whether patients present to specialists in headache, obstetrics, or neurology. These include thunderclap headache with vasospasm, migrainous vasospasm (or crash migraine), migrainous angiitis, drug-induced angiitis, postpartum angiopathy, and benign angiopathy of the central nervous system. The label RCVS is an attempt to unify these various descriptions of a distinct clinico-radiological pattern. Nevertheless, there remains ...
BACKGROUND AND AIM OF THE STUDY: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by severe thunderclap headache, with or without associated neurological symptoms and neuroimaging findings of reversible vasoconstriction of cerebral arteries. Puerperium is a recognized precipitant, but the incidence of puerperal RCVS is unknown. We conducted a prospective study to assess incidence, risk factors and clinical features of RCVS. MATERIAL AND METHOD: Nine-hundred consecutive puerperae were prospectively enrolled within three days of delivery. Past medical history, basal demographic, anthropometric and biological variables were recorded. Transcranial Colour Coded Sonography (TCCS) was performed to assess early signs of vasospasm in brain vessels. A structured telephone interview was planned in all subjects one month postdelivery. RESULTS: Thunderclap headache was recorded in 8 subjects (0.9%) on the first visit. At the one month follow-up interview 27 more patients reported having had at
Reversible cerebral vasoconstriction syndrome (RCVS) is a group of conditions with a common clinical and radiologic presentation. It is characterized by thunderclap headache and reversible vasoconstriction of the cerebral arteries. Terminology ...
Reversible cerebral vasoconstriction syndrome (RCVS, sometimes called Call-Fleming syndrome) is a disease characterized by a weeks-long course of thunderclap headaches, sometimes focal neurologic signs, and occasionally seizures. Symptoms are thought to arise from transient abnormalities in the blood vessels of the brain. In some cases, it may be associated with childbirth, vasoactive or illicit drug use, or complications of pregnancy. For the vast majority of patients, all symptoms disappear on their own within three weeks. Deficits persist in a small minority of patients, with severe complications or death being very rare. Because symptoms resemble a variety of life-threatening conditions, differential diagnosis is necessary. The key symptom of RCVS is recurrent thunderclap headaches, which over 95% of patients experience. In two-thirds of cases, it is the only symptom. These headaches are typically bilateral, very severe and peak in intensity within a minute. They may last from minutes to ...
ObjectivesTo further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS).MethodsWe compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively en
Details of the image Reversible cerebral vasoconstriction syndrome (RCVS) with associated convexity subarachnoid haemorrhage, nimodipine-reversibility Modality: DSA (angiography) (External carotid artery)
1) Influence of sodium consumption and associated knowledge on post-stroke hypertension in Uganda 2) e-Pearl topic: Transient cerebral arteriopathy 3) Topic of the month: Neurologic prognosis following cardiac arrest This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Justin Sattin interviews Dr. Larry Goldstein about his paper on the influence of sodium consumption and its associated knowledge on post-stroke patients with and without a history of hypertension in Uganda. Dr. Adam Num Read More 1) Influence of sodium consumption and associated knowledge on post-stroke hypertension in Uganda 2) e-Pearl topic: Transient cerebral arteriopathy 3) Topic of the month: Neurologic prognosis following cardiac arrest This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the ...
RCVS is a cerebrovascular disorder that can be occur as late as 3 weeks after an uncomplicated pregnancy, characteristic neuroimaging finding accompanied by severe and acute headache are important key features to consider RCVS diagnosis.. Here were present a 39-year-old woman, presented with headache and subsequent right hemiparesis 3 weeks after abortion. First brain CT scan was unremarkable. Brain CT angiography showed multiple segmental stenosis and at later scans, she developed sub arachnid hemorrhage (SAH) which is a pathognomonic feature of RCVS. She was treated with calcium channel blocker and headache relieved and hemiparesis was improved. Final diagnosis was made based on normal trans-cranial Doppler (TCD) study after 4 weeks of symptoms onset.. ...
Background and purpose: Atherosclerotic stenosis of major intracranial arteries accounts for 5 to 10% of all causes of stroke. The Warfarin versus Aspirin Symptomatic Intracranial Disease (WASID) Study has demonstrated stroke onset in 5 among 100 patients with asymptomatic intracranial arterial stenosis (AIAS) during the follow-up period of 1.8 years. However, there are no prospective studies of intracranial stenosis in healthy subjects with a longer follow-up period. We conducted a 7-years longitudinal study in healthy subjects with AIAS to examine its risk factors and prognosis.. Methods: We performed a prospective study on 3,155 neurologically normal subjects without history of stroke (1724 men, 1431 woman, mean age of 59). They were followed up with the mean interval of 83 months to obtain information about their stroke event with a questionnaire by mail or telephone interview and inquiry to the relevant medical facilities. AIAS were assessed on MRA at the time of first visit for all ...
Cerebral Vasculitis Definition Vasculitis a condition is characterized by inflammation of the blood vessel walls. Cerebral Vasculitis is one form of this disease that involves the CNS. It usually involves the brain and at times, the spinal cord. Sometimes, the word Vasculitis in the name of the condition is replaced
migraine with aura cerebral infarction and dementia other cerebral vascular disorders in particular cerebral venous thrombosis reversible cerebral vasoconstriction syndrome and cervical artery dissection the genetics and treatment of migraine Jean Pierre Kahane Professor Emeritus Paris Sud University Member of the Académie des sciences Xavier Lacroix Professor Emeritus Lyon Catholic University former Director of the Institut des sciences de la famille de Lyon former Dean of the Theology Faculty of Lyon member of the Academic Corpus of the Académie catholique de France Xavier VANDENDRIESSCHE Professor of Law President Lille 2 Law and Health University Francis Puech Gynaecologist Obstetrician Professor Emeritus President of the Collège National des Gynécologues et Obstétriciens Français National College of French Gynaecologists and Obstetricians President of the Commission Nationale de la Naissance et de la Santé de l Enfant DGS DGOS National Commission on Childbirth and Children s Health ...
Specific patterns of white matter hyperintensities in the brain may guide diagnosis of reversible cerebral vasoconstriction syndrome, a disorder predominantly characterized by severe thunderclap headaches.
Strong correlations between plasma lipoprotein concentrations and the risk of stroke have never been clearly established. Unlike coronary heart disease, there is no significant direct relation between an increased risk of stroke and increased plasma total cholesterol or low density lipoprotein (LDL) cholesterol; nor is there an inverse relation with high density lipoprotein (HDL) cholesterol.1 Indeed, an inverse relation exists between total cholesterol concentrations and cerebral haemorrhage.2. The reasons for this weak or absent relation are several. The most compelling is that virtually all coronary heart disease can be ascribed to coronary atheroma, whereas less than half the incidence of stroke is due to large vessel atheroma. Non-atheromatous causes such as cardiac arrhythmias, small cerebral artery disease, and cortical degeneration are responsible for most of the rest. Another is that, in general, coronary deaths occur at a younger age than strokes, so the population with raised plasma ...
The importance of recognizing and proactively managing impaired swallowing should not be underestimated. Dysphagia is seen in 42-67% of patients within the first 72 hours post stroke.{ref5} Per stroke... more
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
This past weekend I paddled around Misery Island in Manchester, MA, where I live, in a race that my husband created and directed called The Misery Challenge (what a name!). Last year at this very same time, at this very same race, I had been without a voice for 3 months, was so thin I could barely make it up a flight of stairs, and could be found on most days lying down - searching for answers about why I was so sick (misery pretty much describes it). By September I was hospitalized at Mass General in Boston, quarantined in a negative pressurized room, and diagnosed with….tuberculosis. So unlikely. So surprising. So strange. Im still trying to put the pieces together of why and how that happened to me - but mostly I marvel at how far Ive come and how grateful I am to be healthy, strong and able to kayak 4 miles around an island with choppy waves and the force of the Atlantic behind it! But its not an accident either.. I share this because my prognosis for healthy, strong lungs was not good ...
Finally it was time for the headliners, Misery Index. Their muscle bound drummer to his kit and did a bit or warming up as the settings were perfected on his drum triggers. His kick drums sounded great. The band had played an all ages show the night before and they commented on how they were surprised that so many people turned up on the second night to see them. I didn?t go to the all ages show since I feel like some dirty old man when hanging around with a load of 15 year olds. Those shows should not be called ?all ages? but more like ?teens only? since anyone over 19 stands out. Anyway, back to the bar show. As mentioned earlier, I was not expecting a whole lot from the band, and it turns out that was a good thing because as soon as they started playing I looked at Rick with a grin and we both realized we were in for a treat. In the live situation the band didn?t sound like noise, or like grind-core. They played brutal death metal, and they played it tight. The bands riffing chops are killer. ...
If youre sick of banning or deleting troublemakers on your Drupal website, you might want to check out Misery, the module designed to give trolls a taste of their own medicine. Creating a random length delay for a user, redirecting them to a random page, presenting them with a 404 error, and crashi...
Ashley EilandCMS 205.___ October 17, 2013 Title: The effects of Human Trafficking INTRODUCTION Attention-Getter -The unjustified trade and enslavement of...
Tony Vigorito is the author of the award-winning and critically-acclaimed underground hits, Just a Couple of Days, Nine Kinds of Naked, and Love and Other Pranks. Visit to read extended samples from all of his novels ...
Freezing solid for months, then working frantically, to a deadline, while the rest of my life goes to hell in a handbasket. This does not work well. My resistance to regular research hours is phenomenal, though I know thats what would work for me. When things reach crisis point I will go and work in a café, which seems to help, if only because no one can find me there ...
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL), familial vascular leukoencephalopathy. Cerebral Autosomal Dominant Arteriopathy
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
The antidepressant, which may take weeks to begin working,. Citalopram is part of a class of drugs called selective serotonin reuptake inhibitors,.5 going from citalopram to lexapro 6 does lexapro or zoloft cause more weight gain. 9 is it ok to take lexapro every other day 10 lexapro high dose side effects.Take citalopram at around the. to explain any part you do not understand. Take citalopram exactly. Celexa oral: Uses, Side Effects, Interactions, Pictures.Reversible cerebral vasoconstriction syndrome:. Reversible cerebral vasoconstriction syndrome in a. not to take Hydroxycut and citalopram,.can you take niacin with celexa Celexa make u sleepy, i like celexa better than lexapro Celexa no prescription medicine. Citalopram is any dairy product can cause.. Community Experts online right now. Ask for FREE. Ask Your Question Fast!.What You Need to Know about Citalopram Withdrawal. When taking anti-depressants such as Citalopram, patients must not discontinue use without the advice of a ...
Neuroborreliosis affects the nervous system after systemic infection with the spirochete Borrelia burgdorferi. Previously, cerebral vasculitis has been regarded as an extremely rare complication of neuroborreliosis. The data on the long-term outcome in patients with cerebral vasculitis due to neuroborreliosis are limited. The objective of this study was to perform a longitudinal analysis of cases of neuroborreliosis-associated cerebral vasculitis. We recruited all patients (n = 11) diagnosed with neuroborreliosis-associated in three neurological departments in an East German region. Inclusion criteria were sudden neurological deficits, magnetic resonance (MR) imaging findings that conform to cerebral ischemia or brain infarction, intrathecal synthesis of borrelia-specific antibodies, and non-atherosclerotic pathology of brain supplying arteries. Vasculitic changes were detected by digital subtraction angiography, MR angiography and/or transcranial Doppler ultrasound. Outcomes were measured by ...
Details of the image Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Modality: MRI (T2)
Details of the image Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Modality: MRI (Ax T2 C2-T1)
© Cambridge University Press 2014. Introduction: Cerebral ischemia is thought to be an important disease mechanism in cerebral small vessel disease (SVD). It has been hypothesized that acute ischemia in the territory of the perforating artery results in lacunar stroke, while chronic ischemia occurring in the distal territories of the perforating arteries results in changes to cerebral white-matter, known as leukoaraiosis. The spatial pattern of leukoaraiosis, with changes first occurring in the brain regions furthest from the origin of the perforating arteries, would be consistent with disease occurring due to hypoperfusion. This has led to the suggestion that cerebral blood flow (CBF) is reduced in SVD, and many studies have been performed to investigate this issue. In addition, cerebral arteriopathy underlying SVD may also impair the ability of small cerebral vessels to vasodilate, leading to problems maintaining perfusion in response to drops in blood pressure and perfusion pressure. Impairments of
The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respectively (MCAO-D1 and MCAO-D7, n = 8 for each group). The other animals were divided into 3 groups: SHAM-D1 (n = 6), SHAM-D7 (n = 6) and Control (n = 8). Rats performed 4 behavioral tests (the elevated body swing test, the beam balance test, the ladder-climbing test and the forelimb grip force) before the surgery and daily after MCAO-r. H-reflex on triceps brachii was measured before and after isometric exercise. Infarction size and cerebral edema were respectively assessed by histological (Cresyl violet) and MRI measurements at the same time points than H-reflex recordings. Animals with cerebral ischemia showed persistent functional deficits during the ...
Reversible Cerebral Vasoconstriction Syndromes (RCVS) comprises a group of diverse conditions, all characterized by spasm of the brain vessels. The main symptom of RCVS is sudden, severe headaches. Strokes or bleeding into the brain may or may not be present. RCVS was previously named benign angiopathy of the central nervous system (BACNS) but the term was recently changed to include other similar disorders.. RCVS is a major mimic of central nervous system vasculitis and should be distinguished from it given the difference in the treatment and the outlook between the two disorders.. Abnormality in the control of brain blood vessel pressure is believed to be the critical element in the pathophysiology of RCVS. The alteration in vascular tone may be spontaneous or evoked by various exogenous or endogenous factors. There is no evidence of vasculitic changes in the brain tissue in RCVS.. It is essential for clinicians evaluating patients for CNS vasculitis to be aware of RCVS and to distinguish it ...
BACKGROUND AND PURPOSE: Elevated OEF is a surrogate for misery perfusion. Our aim was to detect misery perfusion in patients with unilateral steno-occlusive disease of the ICA or MCA by using T2*-based MR imaging and to determine the relationship between brain ischemia and OEF.. MATERIALS AND METHODS: Twenty-three patients with unilateral steno-occlusive disease of the ICA or MCA and 8 healthy volunteers were included in this study. Hemodynamic information was obtained in all subjects by MR imaging. Three regions of interest were placed in the anterior, middle, and posterior parts of the brain bilaterally to measure the OEF and CBF values, The OEFs of the regions of interest in the hemispheres ipsilateral and contralateral to the vascular lesions were compared. Brain regions with OEF greater than that in controls were determined as misery perfusion in patients. The association of vascular lesions, rCBF, and the presence of territory infarction with elevated OEF was investigated.. RESULTS: There ...
Amnesia & Cerebral Vasculitis or Vasculopathy & Memory Impairment Symptom Checker: Possible causes include Stroke. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Female gender, which is abolished following ovariectomy and reproductive senescence, is associated with improved outcome following cerebral stroke. Estrogen replacement partially restores this benefit of the female gender but the effect of progesterone in hormone-deficient animals is currently unknown. We evaluated various outcomes following middle cerebral artery occlusion (MCAO) in ovariectomised female mice, with a physiologically relevant restoration of progesterone levels. Ovariectomised female mice had significantly elevated plasma (P=,0.05) and brain progesterone levels (P=,0.01) following implantation of a 21-day release pellet (50mg) compared with mice that received placebo implants 7 days prior to undergoing 60 min MCAO. Assessment of well-being (body weight recovery) and neurological score at 24h and 48h post-MCAO indicated that MCAO significantly worsened outcome compared with sham-operated mice but progesterone had no effect. MCAO resulted in a substantial lesion formation and a ...
A recent large series7 found specific vasculopathies in 18% of pediatric ischemic strokes. We identified recognizable vasculopathies in almost 25% of our patients with arterial ischemic stroke. This percentage may underestimate their prevalence because not all patients in our series underwent vascular imaging. These findings underline the importance of vascular investigation in all arterial ischemic strokes in children. Moyamoya was the most frequent recognizable vasculopathy in our cases of ischemic stroke. Although the exact pathophysiologic mechanism of moyamoya remains unknown, it has been associated with many conditions, including trisomy 21 and congenital heart disease.15,16 The association of moyamoya with lupus anticoagulant17 or with a significantly elevated blood level of IgG aCLA18,19 also has been reported, albeit rarely. We report here two more cases of moyamoya associated with aCLA and arterial ischemic stroke. Surprisingly, in our series, aCLA was found in 2 of 6 patients with ...
When blood flow to part of the brain is blocked or reduced, the brain tissue is impacted and brain cells begin to die. This is known as a stroke. When an infant or child under the age of 18 has a stroke, it is known as a pediatric stroke.
Students will have the choice on what claim they will make (misery or hope) using the photographs that were shown previous to this part of the lesson. Students will have the rest of the period in order to write an essay explaining whether the Great Depression was a time of misery or a time of hope. The students will have the remainder of the period to write their response. If the students do not finish, it will be assigned for homework for the following period ...
Typefaces have predetermined spacing between words that is dictated by the point size and width of a typestyle, the darkness or density of the typeface, and the openness or tightness of the letterspacing. For text set ragged right (unjustified), word spacing may be fixed and unchanging. However, for text that is set flush left and flush right (justified), the spacing may need to be more flexible. For justified text, an average word space of a fourth of an em is ideal, with a minimum and maximum range of a fifth of an em to half an em. |
Typefaces have predetermined spacing between words that is dictated by the point size and width of a typestyle, the darkness or density of the typeface, and the openness or tightness of the letterspacing. For text set ragged right (unjustified), word spacing may be fixed and unchanging. However, for text that is set flush left and flush right (justified), the spacing may need to be more flexible. For justified text, an average word space of a fourth of an em is ideal, with a minimum and maximum range of a fifth of an em to half an em. |
Im so happy to have Susan Neal on the blog today as I celebrate the big reveal of my website makeover. Its always more fun to celebrate with friends! If youve been with me for any length of time, you know that God has taken the trial of chronic illness in my life and redeemed…
I will confess that I can be short with ones who think I have money I can give them (HA!), and who havent seen anything, theyre just trying to cheat me out of the money. An effective way to get rid of them is to point out that if I need to spend a substantial amount of time examining their photos or watching their video, I am going to have to charge a CONSULTING FEE ...
Rory McIlroy, armed with advice from Australian Greg Norman, returns to the scene of his first PGA Tour title looking to regain his stride after a stunning blowup at last month`s Masters.
I POAS this morning 2days before af is due, just to put myself out of my misery, it was a very faint BFP!!! trying no to get excited but when i have tested before have had nothing in that window!! keeping legs crossed until 2moro so i can test again, how hard will that be, am so shocked cos was convinced otherwise!!!good luck to everyone!!x ...
arterial biopsy showing polymorphonuclear cells. Kawasaki disease. Usually in children(age,4), it affects large, medium, and ... Isolated cerebral vasculitis. Affects medium and small arteries over a diffuse CNS area, without symptomatic extracranial ... Aortitis can also be considered a large-vessel disease.[10] Takayasu arteritis. Primarily affects the aorta and its main ... Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy. ...
"Cerebral Small Vessel Disease: Capillary Pathways to Stroke and Cognitive Decline." Journal of Cerebral Blood Flow & Metabolism ... "Vascular remodelling of small and large vessels provoked by arterial hypertension is the initial step in the development of ... studies that link cerebral small vessel diseases to cognitive decline and lipohyalinosis being a cerebral small vessel disease ... Cerebral small vessel disease is a major cause of cognitive decline in the older populations. The results from a small pilot ...
Peripheral arterial occlusions, in the absence of underlying atherosclerotic vascular disease, resulting in extremity ischemia ... Cerebral vein thrombosis. Portal vein thrombosis, hepatic vein, or other intra-abdominal thrombotic events. Jugular vein ... Myocardial infarction, in the absence of severe coronary artery disease Stroke and/or transient ischemic attack, in the absence ... of severe atherosclerotic disease and at an age less than 60 years. Central retinal vein and/or central retinal arterial ...
It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's ... Raynaud's disease and other syndromes caused by altered peripheral irrigation. Migraines of vascular origin Coadjutant therapy ... Acute and chronic cerebral metabolic-vascular disorders (cerebral arteriosclerosis, thrombosis and cerebral embolism, ... The primary action of nicergoline is to increase arterial blood flow by vasodilation. Furthermore, it is known that nicergoline ...
This disease is further divided into three subgroups, namely neonatal arterial ischemic stroke (NAIS), neonatal cerebral ... Neonatal cerebral sinovenous ischemic stroke is a disease in the cerebral venous system caused by thrombosis. Thrombosis in ... This situation normally affects the middle cerebral arterial region. This subgroup of perinatal stroke affects between 5 to 43 ... The prognosis of this disease is associated with the severity and the development of the symptoms. This disease can be treated ...
In the brain a cerebral arteriovenous malformation causes arterial blood to be directly shunted into the veins as there is an ... "Microcystic lymphatic malformation , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". ... "Biology of cerebral arteriovenous malformations with a focus on inflammation". Journal of Cerebral Blood Flow and Metabolism. ... Capillary malformations in the brain are known as cerebral cavernous malformations or capillary cavernous malformations (CCMs ...
... is used to diagnose arterial and venous disease. This is particularly important in neurology, where carotid ultrasound is used ... Blood velocity can be measured in various blood vessels, such as middle cerebral artery or descending aorta, by relatively ... Its aim is often to find a source of a disease or to exclude pathology. The practice of examining pregnant women using ... In nephrology, ultrasonography of the kidneys is essential in the diagnosis and management of kidney-related diseases. The ...
He has written and published extensively on cerebral aneurysms, cerebrovascular arterial dissections, and collagen vascular ... disease as related to the central nervous system. Schievink is also an expert and well published author on Spontaneous ...
... spinal cord disease, 7) Addison's disease, 8) cerebral salt wasting, and 9) syndrome of inappropriate antidiuretic hormone ... "Impairment of urine diluting ability related to ADH" occurs in nine situations: 1) arterial volume depletion 2) hemodynamically ... Addison's disease and congenital adrenal hyperplasia in which the adrenal glands do not produce enough steroid hormones ( ... Baylis, PH; Thompson, CJ (November 1988). "Osmoregulation of vasopressin secretion and thirst in health and disease". Clinical ...
... for peripheral arterial disease or obstructive arterial disease.[20][21][22] There is no accepted diagnostic standard for ... a finding consistent with reduced local cerebral blood flow[49] and a heightened risk of cerebrovascular disease.[50] Within ... Systemic arterial pressure[edit]. The Task Force for the management of arterial hypertension of the European Society of ... Coffman JD (December 1988). "Pathophysiology of obstructive arterial disease". Herz. 13 (6): 343-50. PMID 3061915.. ...
... cerebral large vessel disease (LVD) atau ateroskeloris, 30,3% dalam SVD dan 14,3% dalam cardioembolic disease. Dalam pronosis ... Sindrom platipnea-ortodeoksia merupakan kondisi yang jarang terjadi dengan simtoma berupa dispnea dan desaturasi arterial. PFO ... impaired cerebral autoregulation dan perubahan protrombotik dipercaya merupakan penyebab cerebral small vessel disease (SVD). ... Berdasarkan studi hasil otopsi, penderita diabetes mellitus rentan terhadap infark lakunar dan cerebral small vessel disease. ...
Lola died of arterial disease on June 22, 1981 in Santa Barbara, California, aged 75. Rosemary died on November 25, 1974, at ... the Motion Picture Country Hospital in Woodland Hills, California, aged 61, from a cerebral blood clot, stemming from diabetes ... West and Lola remained married until his death on March 31, 1952, from heart disease. Lola married Robert Hanlon three years ...
... "pathology of arterial hypertension", which received the proper medical attention from his date of admission and was even ... all of which could have produced complications in the pathology of cerebral toxoplasmosis", which according to the tribunal led ... The TSJ says that the councilman Carlos Andrés García died from an immunodeficient disease]. La Información (in Spanish). 19 ... The TSJ of Venezuela says that Councilman Carlos Andrés García died from an immunodeficient disease] (in Spanish). Europa Press ...
Among numerous diseases potentially occurring from endothelin dysregulation are: several types of cancer cerebral vasospasm ... An ETA-selective antagonist, ambrisentan was approved for treatment of pulmonary arterial hypertension in 2007, followed by a ... heart disease, and potentially other diseases. Endothelins are 21-amino acid vasoconstricting peptides produced primarily in ... Endothelins are implicated in vascular diseases of several organ systems, including the heart, lungs, kidneys, and brain. As of ...
... intracranial arterial diseases MeSH C14.907.253.560.200 - cerebral arterial diseases MeSH C14.907.253.560.200.175 - cadasil ... cerebral arterial diseases MeSH C14.907.253.337.187 - cadasil MeSH C14.907.253.337.375 - infarction, anterior cerebral artery ... posterior cerebral artery MeSH C14.907.253.337.750 - moyamoya disease MeSH C14.907.253.378 - intracranial embolism and ... anterior cerebral artery MeSH C14.907.253.480.200.200.450 - infarction, middle cerebral artery MeSH C14.907.253.480.200.200.475 ...
... family history of cerebral aneurysm, infection, and trauma. Damage to structural integrity of the arterial wall by shear stress ... Intracranial aneurysms may result from diseases acquired during life, or from genetic conditions. Lifestyle diseases including ... Cerebral bypass surgery[edit]. Cerebral bypass surgery was developed in the 1960s in Switzerland by Gazi Yasargil, M.D. When a ... Some individuals with a ruptured cerebral aneurysm die from the initial bleeding. Other individuals with cerebral aneurysm ...
Blood from a ruptured cerebral aneurysm clots around a cerebral artery, releasing thrombin. This can induce an acute and ... The previously reported relationship of inflammatory bowel disease (i.e., Crohn's disease or ulcerative colitis) and ... but ineffective and not indicated for massive or brisk arterial bleeding. Thrombin is sold under the brand name Fibrimex for ... Various rare diseases involving prothrombin have been described (e.g., hypoprothrombinemia). Anti-prothrombin antibodies in ...
... understanding and treatment of vascular diseases. Damsa T.; et al. (1976). ""Blood-hammer" phenomenon in cerebral hemodynamics ... already used in vascular physiology to designate an arterial pulse variety, the "water-hammer pulse". Complete understanding of ... The term "blood-hammer" was introduced in cerebral hemodynamics by analogy with the hydraulic expression "water hammer", ... "The influence of the non-Newtonian properties of blood on blood-hammer through the posterior cerebral artery". Mathematical ...
It is also used in cases of cerebral ischemia, ocular ischemic syndrome and other ocular disease caused by disturbed arterial ... Meldonium may be used to treat coronary artery disease. These heart problems may sometimes lead to ischemia, a condition where ... In a study in a transgenic mouse model of Alzheimer's disease, meldonium increased cognition and mental performance by reducing ... "Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice". Journal of Neuroscience ...
... coronary disease and early-onset dementia. Progressive compromise of arterial linings in Sneddon's produces clotting, for which ... severe but transient neurological symptoms thought to be caused by cerebral vasospasm, ... coronary disease and dementia. The skin manifestations may precede the neurologic symptoms by years. Sneddon's syndrome is a ... both worsen in cold and either may occur without Sneddon's Syndrome or any other systemic disease.[citation needed] Sneddon's ...
Artery Atheroma Atherosclerosis Coronary circulation Cerebral circulation vein graft disease, coronary artery bypass surgery, ... event rates without resorting to only arterial bypass surgery or angioplasty/stents to treat the symptoms of advanced disease, ... played in the usual progression of atherosclerotic disease, Dr. Otvos began novel research work in using NMR spectroscopy to ... extensive research on the roles of the various lipoproteins in cardiovascular disease and lead the company, LipoScience, which ...
In particular, patients with Peripheral Arterial Disease have an increased risk of Coronary Artery Disease, and severe ... Either can result in degrees of cerebral ischemia. Carotid artery disease can be typically addressed with open surgical ... Peripheral Arterial Disease (PAD, sometimes PVD or "Peripheral Vascular Disease") is most often a result of atherosclerosis and ... "Correlation between peripheral arterial disease and coronary artery disease using ankle brachial index-a study in Indian ...
It is typically used by patients who have excess calcium in their arteries due to kidney disease. In recent years, STS has also ... cerebral, renal, mesenteric and cardiac arteries Echo-dense aortic annulus, ascending aorta, transverse arch, descending aorta ... "SONOWORLD : Idiopathic infantile arterial calcification". Stuart, G; Wren, C; Bain, H (1990). "Idiopathic infantile arterial ... Generalized arterial calcification of infancy (GACI) is an extremely rare genetic disorder. It is caused by mutations in the ...
... how to diagnose a rare but highly fatal disease". Therapeutic Advances in Musculoskeletal Disease. 5 (6): 305-314. doi:10.1177/ ... Cerebral manifestations may lead to encephalopathy and seizures. Myocardial infarctions may occur. Strokes may occur due to the ... arterial clotting involvement. Death may result from multiple organ failure. Furthermore, the syndrome has been shown to ... Association with another disease such as lupus is called a secondary APS unless it includes the defining criteria for CAPS. ...
December 2000). "Arterial thoracic outlet syndrome with embolic cerebral infarction. Report of a case". Panminerva Medica. 42 ( ... leading to Paget-Schroetter disease or effort-induced thrombosis. TOS can be related to cerebrovascular arterial insufficiency ... arterial compression by itself does not make the diagnosis of arterial TOS (the rarest form of TOS). Lesser degrees of arterial ... Arterial TOS is due to compression of the subclavian artery. This is less than one percent of cases. Venous TOS is due to ...
Paget-Schroetter disease[edit]. Main article: Paget-Schroetter disease. Paget-Schroetter disease is the obstruction of an upper ... Arterial thrombosis[edit]. Arterial thrombosis is the formation of a thrombus within an artery. In most cases, arterial ... Cerebral venous sinus thrombosis[edit]. Main article: Cerebral venous sinus thrombosis. Cerebral venous sinus thrombosis (CVST ... Thrombotic stroke can be divided into two categories-large vessel disease and small vessel disease. The former affects vessels ...
... and mean arterial pressure. The ratio between cerebral blood flow and cerebral blood volume can be an accurate predictor of ... Lassen, N. A. (June 1984). "Cerebral Blood Flow and Blood Volume Tomography by SPECT in Cerebrovascular Disease". Clinical ... Cerebral blood volume has a close and positive correlation with cerebral blood flow. Both cerebral blood volume and cerebral ... "Quantitative Measurement of Cerebral Blood Flow and Cerebral Blood Volume after Cerebral Ischaemia". Journal of Cerebral Blood ...
March 1983). "Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage". The New ... Autosomal dominant polycystic kidney disease (ADPKD), a hereditary kidney condition, is known to be associated with cerebral ... Delayed cerebral ischemia, cerebral vasospasm, seizures[1]. Types. Traumatic, spontaneous (aneurysmal, nonaneurysmal, ... 1st attempt at dilating spastic cerebral arteries in the acute stage of rupture of arterial aneurysms]". Zhurnal Voprosy ...
... reaches the basilar artery or goes around the cerebral arterial circle and descends via the (contralateral) vertebral artery to ... Subclavian steal syndrome (SSS), also called subclavian steal steno-occlusive disease, is a constellation of signs and symptoms ... Takayasu's arteritis is a disease causing inflammation of arteries, including the subclavian artery. Inflammation leaves behind ... associated with other stigmata of vascular disease (e.g. vascular insufficiency ulcers of the fingers). There are multiple ...
Arterial and venous hypoxia, or the deprivation of adequate oxygen supply to certain areas of the brain, occurs when a tumor ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ...
Most commonly, intermittent (or vascular or arterial) claudication is due to peripheral arterial disease which implies ... Other uncommon causes are Trousseau disease,[medical citation needed] Beurger's disease (Thromboangiitis obliterans),[medical ... One in five of the middle-aged (65-75 years) population of the United Kingdom have evidence of peripheral arterial disease on ... "Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population". Int ...
to diagnose and differentiate between obstructive lung disease and restrictive lung disease[5] ... Thoracic, abdominal, or cerebral aneurysms. *Cataracts or recent eye surgery. *Recent thoracic or abdominal surgery ... alveolar-arterial gradient. *hemoglobin. *oxygen-haemoglobin dissociation curve (Oxygen saturation. *2,3-BPG ... The effect of intrinsic positive end-expiratory pressure". The American Review of Respiratory Disease. 131 (5): 672-7. doi: ...
FiO2 should be titrated to maintain arterial oxygen saturation of greater than 90%, bearing in mind that oxygen supply is often ... Progress in Cardiovascular Diseases. 52 (6): 467-484. doi:10.1016/j.pcad.2010.02.003. PMID 20417340.. ... High-altitude cerebral oedema (HACO). High-altitude cerebral edema (HACE) is a medical condition in which the brain swells with ... If a lumbar puncture is performed, it will show normal cerebral spinal fluid and cell counts but an increase in pressure.[7] In ...
The circle of Willis (also called Willis' circle, loop of Willis, cerebral arterial circle, and Willis polygon) is a ... Correlation with cerebral collaterals in internal carotid artery occlusive disease". J Neurol. 253 (10): 1285-1291. doi:10.1007 ... The anterior cerebral artery forms the anterolateral portion of the circle of Willis, while the middle cerebral artery does not ... Cerebral angiogram showing an anterior/posterior projection of the vertebrobasilar and posterior cerebral circulation, the ...
... cerebral disease, and the lupus anticoagulant". Br. Med. J. (Clin. Res. Ed.). 287 (6399): 1088-9. doi:10.1136/bmj.287.6399.1088 ... In APS patients, the most common venous event is deep vein thrombosis of the lower extremities, and the most common arterial ... The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease ... Often, this disease is treated by giving aspirin to inhibit platelet activation, and/or warfarin as an anticoagulant. The goal ...
In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the ... Hypertensive kidney disease. Other names. Hypertensive nephrosclerosis (HN or HNS), hypertensive kidney disease, hypertensive ... "Epidemiology of Hypertensive Kidney Disease".. CS1 maint: uses authors parameter (link). *^ Rowe, D J; Bagga, H; Betts, P B ( ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It ...
In female mice, the deletion of eNOS and COX-1 did not affect mean arterial blood pressure, while males become hypertensive[1] ... Although the role of EDHF in the genesis of Cardiovascular Disease remains to be further elucidated, the EDHF contribution and ... "Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries". Am. J. Physiol. Heart Circ. Physiol. 289 (3 ... endothelial abnormalities associated with pathogenesis of certain diseases. It is widely accepted EDHF plays an important role ...
a b MDGuidelines , Arterial Embolism And Thrombosis From The Medical Disability Advisor by Presley Reed, MD. Retrieved on April ... Forrester JS, Litvack F, Grundfest W, Hickey A (1987). "A perspective of coronary disease seen through the arteries of living ... arterial embolism.[1] Angioscopy is also used as an adjunctive procedure during vascular bypass to visualize valves within ...
... refers to a condition in which an arterial spasm leads to vasoconstriction. This can lead to tissue ischemia and ... Symptomatic vasospasm or delayed cerebral ischemia is a major contributor to post-operative stroke and death especially after ... Beta-receptor antagonists should be avoided in patients with reactive pulmonary disease to avoid asthma attacks. Also Beta- ... tissue death (necrosis). Cerebral vasospasm may arise in the context of subarachnoid hemorrhage. ...
Some examples of neurological damage include hypertensive encephalopathy, cerebral vascular accident/cerebral infarction, ... The risks of developing a life-threatening disease affecting the heart or brain increase as the blood flow increases. Commonly ... In the heart, increased arterial stiffness, increased systolic blood pressure, and widened pulse pressures, all resulting from ... is a manifestation of the dysfunction of cerebral autoregulation.[7] Cerebral autoregulation is the ability of the blood ...
Arterial blood pressure[edit]. Main articles: Baroreflex and Renin-angiotensin system. The brain can regulate blood flow over a ... Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 81-137. doi: ... "Altitude Illness - Cerebral Syndromes". eMedicine Specialties , Emergency Medicine , Environmental.. *^ Alberts, Bruce (2002 ... thereby restricting the outflow of blood from the arterial tree, causing the arterial blood pressure to rise. This, therefore, ...
The best known hemoglobinopathy is sickle-cell disease, which was the first human disease whose mechanism was understood at the ... In the brain, these include the A9 dopaminergic neurons in the substantia nigra, astrocytes in the cerebral cortex and ... Laboratory hemoglobin test methods require a blood sample (arterial, venous, or capillary) and analysis on hematology analyzer ... Role in disease[edit]. Hemoglobin deficiency can be caused either by a decreased amount of hemoglobin molecules, as in anemia, ...
... and potential arterial anastomosis (e.g. coronary arteries and cortical branch of cerebral arteries). Anastomoses also form ... "Annals of Vascular Diseases. 3 (1): 84-86. doi:10.3400/avd.AVDhdi08023. ISSN 1881-641X. PMC 3595814 . PMID 23555395.. ... Arterial anastomosis includes actual arterial anastomosis (e.g., palmar arch, plantar arch) ... Pathological anastomosis results from trauma or disease and may involve veins, arteries, or intestines. These are usually ...
Functional imaging, which is used to diagnose metabolic diseases and lesions on a finer scale (such as Alzheimer's disease) and ... Uptake of SPECT agent is nearly 100% complete within 30 to 60 seconds, reflecting cerebral blood flow (CBF) at the time of ... Functional magnetic resonance imaging (fMRI) and arterial spin labeling (ASL) relies on the paramagnetic properties of ... and neuron-damaging diseases which cause dementia (such as Alzheimer's disease) all cause great changes in brain metabolism, ...
Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... COUGHLIN, P; MAVOR, A (1 October 2006). "Arterial Consequences of Recreational Drug Use". European Journal of Vascular and ... and cerebral hemorrhage.[59][96] Methamphetamine is known to have a high potential for abuse and addiction.[59][96] ... Muriel P, Arauz J (2010). "Coffee and liver diseases". Fitoterapia. 81 (5): 297-305. doi:10.1016/j.fitote.2009.10.003. PMID ...
To counter the effects of high-altitude diseases, the body must return arterial pO. 2 toward normal. Acclimatization, the means ... Cerebral hypoxia - Oxygen shortage of the brain or cerebral anoxia, a reduced supply of oxygen to the brain ... Diseases such as peripheral vascular disease can also result in local hypoxia. For this reason, symptoms are worse when a limb ... Martin, Lawrence (1999). All you really need to know to interpret arterial blood gases (2nd ed.). Philadelphia: Lippincott ...
By acting on vascular smooth muscle, they reduce contraction of the arteries and cause an increase in arterial diameter, a ... Nimodipine (Nimotop) This substance can pass the blood-brain barrier and is used to prevent cerebral vasospasm. ... Negative chronotropy can be beneficial when treating a variety of disease processes because lower heart rates represent lower ... The class of CCBs known as dihydropyridines mainly affect arterial vascular smooth muscle and lower blood pressure by causing ...
Other well known causes include diseases of the kidney. This includes diseases such as polycystic kidney disease which is a ... "The Use of Sodium Chloride, Potassium Chloride, Sodium Bromide, and Potassium Bromide in Cases of Arterial Hypertension which ... It has many different causes including endocrine diseases, kidney diseases, and tumors. It also can be a side effect of many ... Chronic kidney disease. *Kidney disease / renal artery stenosis - the normal physiological response to low blood pressure in ...
Disease. *Addiction. *Cerebral palsy. *Meningitis. *Demyelinating diseases. *Seizures and epilepsy. *Headache. *Stroke ...
Various arterial repair procedures have been described.[1][13] Prognosis[edit]. Prognosis of spontaneous cervical arterial ... The gold standard is cerebral angiography (with or without digital subtraction angiography).[3][14][15] This involves puncture ... autosomal dominant polycystic kidney disease and pseudoxanthoma elasticum,[1] α1 antitrypsin deficiency and hereditary ... This may be explained by the fact that the arterial wall is thinner and lacks a number of structural supports in this section.[ ...
August 2005)։ «Causes and predictors of death in cerebral venous thrombosis»։ Stroke 36 (8): 1720-1725։ PMID 16002765։ doi: ... MedlinePlus , Arterial embolism Update Date: 5/8/2008. Updated by: Sean O. Stitham, MD and David C. Dugdale III, MD. Also ... Monarch Disease Ontology release 2018-06-29sonu - 2018-06-29 - 2018.. ,a href="",,/a, ... Disease Ontology release 2019-05-13 - 2019-05-13 - 2019.. ,a href="",,/a, ...
Nas células, os encimas CK "citosólicos" consta de dúas subunidades, que poden ser de tipo B (tipo cerebral, brain en inglés) ... Schlattner U, Tokarska-Schlattner M, Wallimann T (February 2006). "Mitochondrial creatine kinase in human health and disease". ... cardíaco e liso e está implicada na xeración da presión arterial.[6] ... 1991 [4]). A estrutura atómica da BB-CK de tipo cerebral citosólica resolveuse a 1,4 ángstroms en 1999. (Eder et al. 1999 [5] ...
Descriptions of the event seem to show that he died of a cerebral haemorrhage from vessels long injured by gout: it is highly ... According to Galen's views, the venous system was quite separate from the arterial system, except when they came in contact ... orthopaedic diseases, endocrinology, genomics, clinical pharmacology and translational medicine and therapeutics.[47] ... containing arterial blood and the 'spirits' which flowed from the heart, distributing heat and life to all parts. Like bellows ...
Disease[edit]. Main article: Vascular disease. Blood vessels play a huge role in virtually every medical condition. Cancer, for ... They are roughly grouped as "arterial" and "venous", determined by whether the blood in it is flowing away from (arterial) or ... The term "arterial blood" is nevertheless used to indicate blood high in oxygen, although the pulmonary artery carries "venous ... Atherosclerosis, the formation of lipid lumps (atheromas) in the blood vessel wall, is the most common cardiovascular disease, ...
Arterial and venous hypoxia, or the deprivation of adequate oxygen supply to certain areas of the brain, occurs when a tumor ... Merrel RT (December 2012). "Brain tumors". Disease-a-Month. 58 (12): 678-89. doi:10.1016/j.disamonth.2012.08.009. PMID 23149521 ... Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ...
... and clinical studies in all areas of Alzheimers disease. ... International Journal of Alzheimers Disease is a peer-reviewed ... arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease," American ... Regional Cerebral Blood Flow in Mild Cognitive Impairment and Alzheimers Disease Measured with Arterial Spin Labeling Magnetic ... Alzheimers disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. Arterial spin ...
"Cerebral Arterial Diseases" by people in this website by year, and whether "Cerebral Arterial Diseases" was a major or minor ... "Cerebral Arterial Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Cerebral Arterial Diseases*Cerebral Arterial Diseases. *Arterial Disease, Cerebral. *Cerebral Arterial Disease ... Below are the most recent publications written about "Cerebral Arterial Diseases" by people in Profiles. ...
The aim of this study was to evaluate the relationship between cognitive impairment and brain perfusion using arterial spin ... labelling (ASL) in end-stage renal disease (ESRD) patients... ... Cerebral blood flow (CBF) can be detected by arterial spin ... Toyoda K (2015) Cerebral small vessel disease and chronic kidney disease. J Stroke 17:31-37CrossRefGoogle Scholar ... CBF cerebral blood flow, ESRD end-stage renal disease, PD peritoneal dialysis, MNI Montreal Neurological Institute, NC normal ...
... corpus callosum associated with a decrease in cortical benzodiazepine receptor in large cerebral arterial occlusive diseases ... Atrophy of the corpus callosum associated with a decrease in cortical benzodiazepine receptor in large cerebral arterial ...
Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of Arterial Spin- ... Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of Arterial Spin- ... Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of Arterial Spin- ... Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of Arterial Spin- ...
Arterial spin labeling measurement of cerebral perfusion in children with sickle cell disease. J Magn Reson Imaging 2012;35:779 ... Cerebral blood flow measurement in children with sickle cell disease using continuous arterial spin labeling at 3.0-Tesla MRI. ... In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial ... In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial ...
... ... We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white ... The load of the disease was calculated using an ordinal scale ranging from 0 to 4 (1 point was given for each of the 4 markers ... We found that, in a cohort of hypertensive individuals, the arterial stiffness is associated with the total load of the cSVD, ...
Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of arterial Spin- ... Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of arterial Spin- ... Perfusion of left and right anterior cerebral artery, MCA, and posterior cerebral artery territories was qualitatively assessed ... Perfusion of left and right anterior cerebral artery, MCA, and posterior cerebral artery territories was qualitatively assessed ...
Cerebral Infarction, Cerebral Arterial Stenosis, and Moyamoya Disease. Si Un Lee1,2, Tackeun Kim1,2, O-Ki Kwon1,2, Jae Seung ... Cerebral Infarction, Cerebral Arterial Stenosis, and Moyamoya Disease Si Un Lee, Tackeun Kim, O-Ki Kwon, Jae Seung Bang, Seung ... cerebral infarction (CI), cerebral arterial stenosis (CASTN), and moyamoya disease (MMD), based on Korean National Health ... Cerebral arterial stenosis (CASTN) and moyamoya disease (MMD) are important causes of IS, especially in Asian populations [3,6, ...
Changes of middle cerebral arteries and basilar arteries were extremely rare, thus we can say that these vessels are influenced ... Anatomical and topographic changes of cerebral vessels were most frequently found in hypertensive patients with high and very ... the most common changes of cerebral vessels diagnosed in MDCTA among patients with hypertension included various degrees of ... MDCT angiography is a highly informative method to study changes of cerebral vessels in patients with hypertension. The ...
Background Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large ... peripheral artery disease; coronary artery disease; arterial hypertension; cerebral hemorrhage; or carotid stenosis. The ... These include coronary artery disease, peripheral arterial disease, rheumatic heart disease, heart failure, ischemic stroke, ... stable coronary artery disease pathophysiology [23]; prognostic biomarkers in peripheral arterial occlusive disease [24]; ...
Cerebral Infarction. Ischemia. Cerebrovascular Disorders. Brain Diseases. Central Nervous System Diseases. Nervous System ... Condition or disease Intervention/treatment Phase Perinatal Arterial Ischemic Stroke Biological: Autologous Cord Blood Infusion ... Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Arterial Ischemic Stroke. The safety and scientific ... Hepatic disease or altered liver function as defined by SGPT , 150 U/L, and/or T. Bilirubin ,1.3 mg/dL at enrollment ...
Condition or disease Intervention/treatment Phase Obstructive Sleep Apnea Hypertension Cardiovascular Diseases Stroke Other: ... Cerebral Blood Flow [ Time Frame: Six weeks ]. The cerebral blood flow will be mesauresed during each testing days of all three ... Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With ... Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With ...
ObjectiveTo describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while ... Reversible Segmental Cerebral Arterial Vasospasm and Cerebral InfarctionPossible Association With Excessive Use of Sumatriptan ... Reversible Segmental Cerebral Arterial Vasospasm and Cerebral InfarctionPossible Association With Excessive Use of Sumatriptan ... Objective To describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while ...
Paeonia lactiflora reduced cerebral ischemia and arterial intimal hyperplasia.Dec 31, 2012. ... Diseases : Alzheimers Disease, Depression, Epilepsy, Ischemia, Neurodegenerative Diseases, Parkinsons Disease, Traumatic ... Diseases : Ischemia, Peripheral Arterial Disease. Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, ... Diseases : Arteriosclerosis, Cardiovascular Diseases, Hypertension, Ischemia. Pharmacological Actions : Anti-Bacterial Agents, ...
Complications of Diagnostic Intra-arterial Cerebral Angiography in Ischemic Cerebrovascular Diseases Kyung-Yul LEE; Seo-Hyun ... Intra-arterial cerebral angiography, which is a prerequisite for carotid endarterectomy and angioplasty, carries some risks but ... Complications of Diagnostic Intra-arterial Cerebral Angiography in Ischemic Cerebrovascula ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Arteries / Humans / Cerebral Angiography / Brain Ischemia / ...
Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations ... Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations ... The syndrome feeds into the developing of diseases like diabetes mellitus, coronary diseases, cerebrovascular disease and other ... anterior cerebral artery, middle cerebral arteries, posterior cerebral artery, intracranial segment of vertebral artery and ...
Cerebral thrombosis. *Arterial thromboembolism. *Hypertension. *Pulmonary embolism. *Gallbladder disease. *Myocardial ... Case control studies provide a measure of the relative risk of a disease, namely, a ratio of the incidence of a disease among ... Gallbladder Disease:. Oral contraceptive users probably have a greater risk than nonusers of having gallbladder disease, ... Women with a history of hypertension or hypertension-related diseases, or renal disease should be encouraged to use another ...
Uncontrolled cardiac disease. *Prior cerebral vascular accident. *Uncontrolled arterial hypertension. *Severe renal or hepatic ... Colonic Diseases. Fluorouracil. Capecitabine. Digestive System Diseases. Gastrointestinal Diseases. Intestinal Diseases. Rectal ... Condition or disease Intervention/treatment Phase Colorectal Cancer Biological: bevacizumab Drug: capecitabine Drug: ... At 14 days after completing chemotherapy, patients with progressive or stable disease receive maintenance therapy comprising ...
Conquering cardiovascular disease: progress and promise. [JAMA. 1999]. *Intra-arterial prourokinase for acute ischemic stroke. ... Prolyse in Acute Cerebral Thromboembolism.. Furlan A1, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, ... Intra-arterial prourokinase for acute ischemic stroke. [JAMA. 2000]. *Intra-arterial prourokinase for acute ischemic stroke. [ ... Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. ...
2009) Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease. Alzheimers Res Ther 1:6, doi:10.1186 ... may be driven in part by arterial pulsation. In each of these studies, the authors sought to alter cerebral arterial pulsation ... Cerebral vasculature is imaged by intra-arterial injection of Texas Red-conjugated dextran-70 (TR-d70; MW, 70 kDa). D, At the ... However, cerebral arterial pulsation could not be directly assessed. In the present study, we use in vivo two-photon microscopy ...
Study of the subcortical cerebral blood flow metabolism in patients with Parkinson′s disease using arterial spin labeling ... The cerebral blood flow (CBF) maps derived from 3D ASL were coregistered to the Montreal Neurological Institute brain space. ... [email protected]#To investigate alterations of blood perfusion in subcortical regions in patients with Parkinson′s disease (PD) by ... Study of the subcortical cerebral blood flow metabolism in patients with Parkinson′s disea ...
... and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic ... Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study. R P Kloppenborg, P J Nederkoorn, A M Grool ... METHOD: In 578 patients [63 (s.d.=8) years] of the Second Manifestations of ARTerial disease (SMART)-Medea study, volumes of ... The Second Manifestations of ARTerial disease--Magnetic Resonance (SMART-MR) study. Minke Kooistra, Mirjam I Geerlings, Yolanda ...
Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease Using 3D ... Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment that provides a quantitative map of cerebral ... The goal of the current study is to demonstrate arterial transit map calculation as well as CBF based on a two-compartment ... However, it has not been investigated whether the hemodynamic changes in patients with occlusive cerebrovascular disease which ...
Hemoglobin, hematocrit, and changes in cerebral blood flow: the Second Manifestations of ARTerial disease-Magnetic Resonance ... title = "Hemoglobin, hematocrit, and changes in cerebral blood flow: the Second Manifestations of ARTerial disease-Magnetic ... Hemoglobin, hematocrit, and changes in cerebral blood flow: the Second Manifestations of ARTerial disease-Magnetic Resonance ... T1 - Hemoglobin, hematocrit, and changes in cerebral blood flow: the Second Manifestations of ARTerial disease-Magnetic ...
Previous studies have suggested that DTI metrics are sensitive in capturing early disease-associated WM changes in preclinical ... Previous studies have suggested that DTI metrics are sensitive in capturing early disease-associated WM changes in preclinical ... may be impacted early in Parkinson disease (PD). Diffusion magnetic resonance imaging (dMRI) has been used extensively to ... and orientation along with WM-dependent structural connectivity may be impacted early in Parkinsons disease (PD). Diffusion ...
KEYWORDS: Computer-aided Classification (CAD); Alzheimers Disease; Magnetic Resonance Imaging (MRI); Arterial Spin Labeling ( ... The cerebral cortical thickness and cerebral blood flow (CBF), which are considered as morphological and functional image ... ABSTRACT: Alzheimers disease (AD) is a dementing disorder and one of the major public health problems in countries with ... We applied two systems based on an arterial neural network (ANN) and a support vector machine (SVM), which were trained with 4 ...
KEYWORDS: Computer-aided Classification (CAD); Alzheimers Disease; Magnetic Resonance Imaging (MRI); Arterial Spin Labeling ( ... The cerebral cortical thickness and cerebral blood flow (CBF), which are considered as morphological and functional image ... ABSTRACT: Alzheimers disease (AD) is a dementing disorder and one of the major public health problems in countries with ... We applied two systems based on an arterial neural network (ANN) and a support vector machine (SVM), which were trained with 4 ...
V. Progress report of prognosis following surgery or nonsurgical treatment for transient cerebral ischemic attacks and cervical ... Carotid Artery Diseases / classification * Carotid Artery Diseases / complications * Carotid Artery Diseases / mortality* ... Joint study of extracranial arterial occlusion. V. Progress report of prognosis following surgery or nonsurgical treatment for ... transient cerebral ischemic attacks and cervical carotid artery lesions JAMA. 1970 Mar 23;211(12):1993-2003. doi: 10.1001/jama. ...
Results: MT failed in 148 (25.0%) of the 591 patients with internal carotid artery or middle cerebral artery M1 occlusion. Of ... ASPECTS indicates Alberta Stroke Program Early CT Score; BGC, balloon guide catheter; CAD, coronary artery disease; GPI, ... intra-arterial; ICA, internal carotid artery; IQR, interquartile range; IV, intravenous; MT, mechanical thrombectomy; NIHSS, ... We identified the patients who underwent MT but failed to recanalize intracranial internal carotid artery or middle cerebral ...
  • To determine the clinical efficacy and safety of intra-arterial (IA) recombinant prourokinase (r-proUK) in patients with acute stroke of less than 6 hours' duration caused by middle cerebral artery (MCA) occlusion. (
  • The deep penetrating arteries are small, nonbranching end arteries (usually smaller than 500 μm in diameter), which arise directly from much larger arteries (eg, the middle cerebral artery, anterior choroidal artery, anterior cerebral artery, posterior cerebral artery, posterior communicating artery, cerebellar arteries, basilar artery). (
  • Novel Hemicraniectomy Technique for Malignant Middle Cerebral Artery Infarction: Technical Note. (
  • Decompressive hemicraniectomy (DH) is the mainstay of treatment for malignant middle cerebral artery infarction (MMI). (
  • Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial. (
  • The colloid transfusion during surgical decompressive hemicraniectomy (DHC) after space-occupying cerebral infarction induced by middle cerebral artery (MCA), is controversial. (
  • Stereotactic Aspiration of Necrotic Brain Tissue for treating Malignant Middle Cerebral Artery Infarction: A Report of 13 consecutive Cases. (
  • Relationship between middle cerebral parent artery asymmetry and middle cerebral artery aneurysm rupture risk factors. (
  • In BriefThe authors demonstrated that a greater degree of parent artery asymmetry for middle cerebral artery (MCA) aneurysms is associated with high-risk features. (
  • The purpose of this study is to determine if patients with malignant middle cerebral artery infarction have a better clinical outcome after early decompressive surgery compared to standard. (
  • Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy. (
  • The aim of the study is to demonstrate that patients with malignant middle cerebral artery infarcti. (
  • Space-occupying, malignant middle cerebral artery (M-MCA) infarctions are still one of the most devastating forms of ischemic stroke, with a mortality of up to 80% in untreated patients. (
  • The aim of the research was to evaluate independent risk factors for the presence of middle cerebral artery aneurysm. (
  • This is a open label study to assess the safety of autologous bone marrow transplantation in patients with a ischemic stroke in the middle cerebral artery territory within 90 days from sym. (
  • NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. (
  • We identified the patients who underwent MT but failed to recanalize intracranial internal carotid artery or middle cerebral artery M1 occlusion. (
  • MT failed in 148 (25.0%) of the 591 patients with internal carotid artery or middle cerebral artery M1 occlusion. (
  • RS seemed considered in MT-failed internal carotid artery or middle cerebral artery M1 occlusion. (
  • To test the hypothesis, we compared functional outcome at 3 months, symptomatic intracranial hemorrhage (sICH), and mortality between RSG and NSG in a cohort of patients in whom MT had failed to recanalize intracranial internal carotid artery (ICA) or middle cerebral artery (MCA) M1 occlusion. (
  • We report 2 consecutive cases of successful local intra-arterial thrombolysis (LIT) for embolic stroke of the middle cerebral artery (MCA) during diagnostic coronary angiography that resulted in complete neurological recovery. (
  • Hyperperfusion syndrome with hemorrhage after angioplasty for middle cerebral artery stenosis. (
  • We report a similar complication after distal intracranial (middle cerebral artery [MCA] M2 segment) angioplasty. (
  • 2) Are her findings due to a small lesion or a large infarct as seen in the typical ACA (anterior cerebral artery) and MCA (middle cerebral artery) distributions? (
  • Methods- Patients with steno-occlusion in the internal carotid artery or middle cerebral artery (MCA) at our institution between 2007 and 2013 were retrospectively studied. (
  • Leptomeningeal collaterals (LMCs) play a pivotal role in sustaining cerebral perfusion in patients with steno-occlusive disease of the internal carotid artery (ICA) and middle cerebral artery (MCA). (
  • To analyze trends in the incidence and treatment of diseases associated with ischemic stroke, namely, cerebral infarction (CI), cerebral arterial stenosis (CASTN), and moyamoya disease (MMD), based on Korean National Health Insurance Service (NHIS) data from 2008 to 2016. (
  • Autologous human umbilical cord blood (hUCB) stored at Cord Blood Registry will be given to children who have suffered from a Perinatal Arterial Ischemic Stroke. (
  • We attempted to examine the inci-dence of complications associated with cerebral angiography in patients with ischemic stroke . (
  • We retrospec-tively reviewed the medical records of patients with ischemic stroke or transient ischemic attack (TIA) who underwent the digital subtraction cerebral angiography . (
  • Cerebral angiog-raphy in patients with ischemic stroke was associated with 1.4 % reversible and 1.0% persistent neurologic complica-tions, all of which developed after the angiographic procedure . (
  • Intra-arterial prourokinase for acute ischemic stroke. (
  • Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. (
  • Cerebrovascular diseases include stroke , transient ischemic attack (TIA), aneurysm , and vascular malformation. (
  • Brain computed to- confined to the respiratory tract but can induce neu- mographic scan revealed many recent ischemic in- rologic diseases ( 1 ). (
  • Background- Intra-arterial cerebral angiography is associated with a low risk for neurological complications, but clinically silent ischemic events after angiography have been seen in a substantial number of patients. (
  • Conclusions- Air filters and heparin both reduce the incidence of silent ischemic events detected by DW-MRI after intra-arterial cerebral angiography and can potentially lower clinically overt ischemic complications. (
  • The study cited by the authors in support of this statement does not mention carotid artery stenosis and instead uses the general term cerebrovascular disease, which includes conditions more likely to cause dizziness, such as stroke (nonspecific dizziness) and vertebrobasilar transient ischemic attack (vertigo). (
  • Vascular diseases of the nervous system: ischemic cerebrovascular disease. (
  • Carotid endarterectomy was beneficial for patients with recent, nondisabling cerebral ischemic events and ipsilateral severe (70% to 99%) carotid stenosis. (
  • Many clinicians believed that persons with cerebral ischemic symptoms associated with high-grade carotid stenosis benefited from carotid endarterectomy. (
  • Only includes ischemic heart disease and cerebrovascular disease. (
  • Recent studies comparing intra-arterial and intravenous thrombolytic therapy in thromboembolic stroke have shown a higher rate of revascularization with intra-arterial thrombolysis. (
  • Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy, commonly known as CARASIL, is an inherited condition that causes stroke and other impairments. (
  • An arterial embolism in the brain (cerebral embolism) causes stroke, which can be fatal. (
  • Stroke, TIA, and subarachnoid hemorrhage are types of cerebrovascular disease. (
  • We describe 2 cases in coronavirus disease patients in lation treated with rivaroxaban (20 mg orally 1×/d), France involving presumed thrombotic stroke that oc- sought care for influenza-like illness and confusion. (
  • On April 3 (day 9 of hospitalization), dysarthria, cated as potential causes of cerebral stroke, such as left hemiplegia, and alteration of consciousness de- herpes simplex virus, varicella zoster virus, Trepo- veloped. (
  • Studies have shown that arterial stiffening is a strong predictor of future cardiovascular events and all-cause mortality and an independent predictor of fatal stroke [ 6 , 7 ]. (
  • focuses on the challenging process of determining the best approach for managing patients with intracranial atherosclerosis, carotid artery disease, stroke, aneurysms, arteriovenous malformations, arteriovenous fistulae, cavernous malformations, and hypervascular tumors. (
  • Soon after the development of appropriate staining methods, it became apparent that both acute (i.e., traumatic brain or spinal cord injury, stroke) and chronic (epilepsy, neurodegenerative diseases) insults to the central nervous system (CNS) are associated with a dramatic change in astrocyte morphology. (
  • Background and Purpose- Impaired cerebrovascular reserve in chronic steno-occlusive disease has been shown to be associated with poor leptomeningeal collaterals (LMCs) on digital subtraction angiography and increased stroke risk. (
  • The onset of this disease is typically between 54 - 66 years of age and the first symptoms are usually mental deterioration or stroke. (
  • the most common changes of cerebral vessels diagnosed in MDCTA among patients with hypertension included various degrees of narrowing of vertebral vessels, anterior, posterior and posterior communicating arteries and internal carotid arteries. (
  • Changes of middle cerebral arteries and basilar arteries were extremely rare, thus we can say that these vessels are influenced by high blood pressure to lesser extent. (
  • CSF from the subarachnoid space moves rapidly into the brain along paravascular routes surrounding penetrating cerebral arteries, exchanging with brain interstitial fluid (ISF) and facilitating the clearance of interstitial solutes, such as amyloid β, in a pathway that we have termed the "glymphatic" system. (
  • Based upon these findings, we proposed that cerebral arteries provide an anatomical pathway to facilitate efficient CSF-ISF exchange in the brain, and that arterial pulsation provides the driving force for this process. (
  • The potential capacity of the collateral system may be limited by occlusion of intracerebral arteries or by involvement of segments of the pial arteries in the disease process. (
  • In arterial emboli, blood flow is blocked at the junction of major arteries, most often at the groin, knee, or thigh. (
  • The previous study has demonstrated that high-resolution MRI can provide superior image quality and reproducibility for the assessment of arterial compliance and endothelial function of the central and peripheral arteries during a single examination [ 13 ]. (
  • Arterial thrombosis, also known as atherothrombosis due to its association with atheroma rupture, occurs in the arteries. (
  • ASL technique was developed in the 90s, using electromagnetically labeled arterial water as a standard diffusible tracer method for measuring perfusion. (
  • Perfusion of left and right anterior cerebral artery, MCA, and posterior cerebral artery territories was qualitatively assessed for arterial spin-labeling-MR imaging and H 2 [ 15 O]-PET by 2 independent readers by use of a 3-point-Likert scale. (
  • NECROSIS occurring in the ANTERIOR CEREBRAL ARTERY system, including branches such as Heubner's artery. (
  • or cerebral venous thrombosis, which is a blood clot in a vein of the brain. (
  • 7 8 9 It is not known whether this is a result of the cerebral vascular system architecture or a pharmacological response to thrombosis and fibrinolysis. (
  • Thrombosis can be broadly classified as either venous thrombosis or arterial thrombosis, according to where the thrombus presents in the body. (
  • MDCT angiography is a highly informative method to study changes of cerebral vessels in patients with hypertension. (
  • The relationship between changes in cerebral blood vessels diagnosed through MDCT angiography and the level of total cardiovascular risk among patients with hypertension had been established. (
  • Patient A 43-year-old man who developed a left occipital infarct after taking a total of 23 sumatriptan succinate tablets (25 mg per tablet) and 32 Midrin tablets during a 7-day period and who on digital subtraction angiography was shown to have segmental cerebral arterial narrowing in multiple vessels. (
  • WE DESCRIBE a patient who experienced a posterior cerebral artery territory infarction while taking an excess of sumatriptan succinate and a combination drug (Midrin) consisting of isometheptene mucate, dichloralphenazone, and acetaminophen and who was found on serial digital subtraction angiography to have reversible segmental arterial vasospasm. (
  • In none of these cases was cerebral angiography reported. (
  • Intra-arterial cerebral angiography , which is a prerequisite for carotid endarterectomy and angioplasty , carries some risks but provides the best visualization of the cerebral vasculatures. (
  • The carotid angiogram, performed immediately after coronary angiography at the beginning of cerebral symptoms, reveals total embolic occlusion of the M2 part of the left MCA with TIMI 0 flow (arrow). (
  • Coronary angiography, performed from the femoral approach with 6F catheters, excluded coronary artery disease. (
  • Complete removal is confirmed with cerebral angiography. (
  • For a pulmonary embolism, a chest x ray, lung scan, pulmonary angiography, electrocardiography, arterial blood gas measurements, and venography or venous ultrasound could be ordered. (
  • Methods and Results- In a prospective study, diffusion-weighted magnetic resonance imaging (DW-MRI) before and after intra-arterial cerebral angiography and transcranial Doppler sonography during angiography were used to evaluate the frequency of cerebral embolism. (
  • Intra-arterial digital subtraction angiography (IA-DSA) has remained the "gold standard" in the assessment of cerebral vessels. (
  • In such disorders as vasculitis or intracranial aneurysms, the sensitivity and specificity of such noninvasive techniques as CT angiography and MR angiography do not suffice to replace intra-arterial angiography. (
  • A high number of microembolic signals (MESs) have been identified by transcranial Doppler sonography during cerebral angiography. (
  • Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. (
  • Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy. (
  • Conclusions Our findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery, whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak. (
  • Hence, HR-MR is considered to become promising imaging modality for intracranial artery disease and many studies have been published recently. (
  • In real clinical arena, intracranial artery disease is too difficult to diagnose and distinguish among the disease. (
  • Of the disease, usefulness of HR-MR has been consistently published in the detection and diagnosis of intracranial artery dissection recently. (
  • The geometric change is the most common among intracranial artery disease. (
  • 3-5 Furthermore, the apposition of thrombus to the embolic material may be an important component of cerebral artery occlusion. (
  • An immediate carotid angiogram to assess cerebral artery occlusion appears to be the best and least time-consuming approach. (
  • in one test, microscopic particles were injected into the carotid artery of rats, mimicing arterial blockage. (
  • 1) The extent and severity of visual field loss has been compared in a series of 14 patients with occlusions of the posterior cerebral artery or its branches, all verified angiographically. (
  • 3) Single or multiple occlusions of the main branches of the posterior cerebral artery gave variable amounts of field loss with considerable recovery in some cases. (
  • Collateral blood flow from the middle cerebral territory and from other branches of the posterior cerebral artery was demonstrated and the variation may be due to the size and number of pial anastomoses and to systemic factors such as blood pressure and vascular reactivity. (
  • 4) Occlusion of smaller branches of the calcarine artery produced localized zones of capillary underperfusion near the posterior cerebral pole. (
  • Two reviews omit dizziness as a symptom of carotid artery disease and include vertigo as a symptom of vertebrobasilar disease only. (
  • Given the demographics of the population with presyncopal dizziness, many patients with dizziness have coexisting carotid artery disease. (
  • We agree that carotid Doppler testing should be reserved for patients in whom clinical suspicion is high, such as those with a history of smoking, peripheral vascular disease, or known carotid artery disease- all of which are shown to be associated with abnormal carotid ultrasound results. (
  • Assessing the association of appropriateness of coronary revascularization and 1-year clinical outcomes for patients with stable coronary artery disease in China. (
  • Imbalance between Fibrin Clot Formation and Fibrinolysis Predicts Cardiovascular Events in Patients with Stable Coronary Artery Disease. (
  • Is coronary artery calcium a biomarker for coronary heart disease? (
  • Therefore, QMRA Δd may be used for the functional assessment of LMC as a surrogate for cerebrovascular reserve in chronic internal carotid artery or MCA steno-occlusive disease. (
  • Results indicate it would be useful in central and peripheral vascular disease, including diabetic angiopathy. (
  • it increases peripheral blood flow with no lessening of cerebral circulation. (
  • in patients with peripheral arterial insufficiency improvement in all experimental measures, including the ability to walk without pain and blood flow to the legs. (
  • Treatment began with IV unfractionated hepa- history of diabetes mellitus, arterial hypertension, rin (18 UI/kg/h), hydroxychloroquine (200 mg oral- coronary heart disease, peripheral arterial disease, ly 2×/d), and antimicrobial drugs (ceftriaxone 1g by and atrial fibrillation (treated with apixaban [2.5 mg IV infusion/d). (
  • Patients needing surgery for peripheral arterial disease (PAD) represent a severe form of atherosclerosis with an overall 5-yr mortality of 30% after revascularisation. (
  • Peripheral arterial disease (PAD) is an atherosclerotic syndrome indicating severe systemic vascular disease [ 1 ]. (
  • Ginkgo biloba is commonly used in the treatment of early-stage Alzheimer's disease, vascular dementia, peripheral claudication, and tinnitus of vascular origin. (
  • Cerebral aneurysms are common and potentially very dangerous. (
  • Sasaguri Y, Kato H: Regression of aneurysms in Kawasaki disease: A pathological study. (
  • We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. (
  • Background and purpose This study aimed to investigate the association of metabolic syndrome (MetS) with both intracranial atherosclerotic stenosis (ICAS) and imaging markers of cerebral small vessel disease (CSVD) in a community-based sample. (
  • Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study. (
  • To assess the possible association of aortic compliance and brachial endothelial function with cerebral small vessel disease in type 2 diabetes mellitus (DM2) patients by using 3.0 T high-resolution magnetic resonance imaging. (
  • Univariable logistic regression analyses were used to analyze the association between PWV and FMD with cerebral small vessel disease. (
  • Multiple logistic regression analyses were used to find out the independent predictive factors of cerebral small vessel disease. (
  • Quantitative evaluation of aortic compliance and endothelial function by using high-resolution MRI may be potentially useful to stratify DM2 patients with risk of cerebral small vessel disease. (
  • Cerebral small vessel disease is one of the common cardiovascular complications in DM2 patients [ 8 ]. (
  • If an association of arterial endothelial dysfunction and arterial compliance abnormalities with cerebral small vessel disease could be established, this would support the significance of measuring arterial endothelial dysfunction and arterial compliance abnormalities for early prediction, stratification, and prevention of this cardiovascular complication in DM2 patients. (
  • It has been reported that PWV is independently associated with cerebral small vessel disease in patients with type 1 DM [ 10 ]. (
  • To our knowledge, there has been no report so far about association between aortic compliance and brachial endothelial function with cerebral small vessel disease in DM2 patients by using magnetic resonance imaging (MRI). (
  • In addition, MRI is superior in the evaluation of lacunar brain infarcts and white matter injuries resulted from cerebral small vessel disease [ 14 ]. (
  • Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy (SAE), is a form of small vessel vascular dementia caused by damage to the white brain matter. (
  • Advanced Neuroimaging to Unravel Mechanisms of Cerebral Small Vessel Diseases. (
  • ERC starting grant 'Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)' (2013, ERC grant agreement n°337333). (
  • The arterial stiffness was tested by measuring the carotid-femoral pulse wave velocity with an oscillometric automatic device. (
  • Dr. Patsalides is expert in the treatment of vascular diseases of the brain and spine and carotid stenosis. (
  • 2 - 4 However, as we stated in our article, tests such as carotid Doppler should be performed only if an underlying cardiac cause is suspected based on other findings or known cardiac disease. (
  • We propose to investigate the impact of such decision aids on patient satisfaction and the outcomes of cerebral aneurysm coiling and clipping. (
  • To determine whether structured decision aids offered to cerebral aneurysm patients are associated with improved quality of life and patient satisfaction outcomes immediately preoperatively, and 30 days postoperatively. (
  • Our study will include patients presenting in the clinic with a diagnosis of cerebral aneurysm. (
  • Patients will be given a few minutes to read through the option grid choices, and will have the chance to ask questions about the two possible treatments (cerebral aneurysm clipping, cerebral aneurysm coiling). (
  • HBP, aneurysm, or cerebral hemorrhage. (
  • An aneurysm is a bulge in the arterial wall that can rupture and bleed. (
  • Objective To describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while taking excessive amounts of sumatriptan succinate and a combination drug (Midrin) consisting of isometheptene mucate, 65 mg, dichloralphenazone, 100 mg, and acetaminophen, 325 mg. (
  • An extensive evaluation for other possible risk factors for cerebral infarction was unrevealing. (
  • Conclusions One should consider the diagnosis of drug-induced vasospasm in patients with cerebral infarction and a history of excessive use of sumatriptan and Midrin. (
  • Four patients with cerebral infarction in association with sumatriptan use have been described previously ( Table 1 ). (
  • The relationship between colloid transfusion during surgical decompression hemicraniectomy period and post-operative pneumonia or long-term outcome after space-occupying cerebral infarction: A retrospective study. (
  • This is a prospective pilot study to determine the utility of MRI and high resolution intracranial vessel wall imaging for the diagnosis and disease activity assessment of intracranial vas. (
  • Arterial endothelial dysfunction and arterial compliance abnormalities are early arterial changes in DM2 patients which occur earlier than structural abnormalities of vessel walls and clinical onset of cardiovascular complications [ 3 - 5 ]. (
  • Aortitis can also be considered a large-vessel disease. (
  • Moyamoya disease and cerebral hemorrhage. (
  • A case with the clinical, x-ray, and computed tomographic features characteristic of moyamoya disease and a large intracerebral hemorrhage is presented. (
  • There is a significant incidence of hemorrhage in the cerebral vasculature after pharmacological intervention with TPA. (
  • Before PD, ESRD patients had increased cerebral perfusion that was related to poorer executive function, especially in the left hippocampus. (
  • Cerebral perfusion assessment is important in the preoperative evaluation and postoperative follow-up of patients with Moyamoya disease. (
  • The objective of this study was to evaluate the correlation of quantitative CBF measurements performed with arterial spin-labeling-MR imaging and H 2 [ 15 O]-PET in children and young adults with Moyamoya disease. (
  • 001).CONCLUSIONS:In children and young adults with Moyamoya disease, quantitative evaluation of CBF is possible with the use of arterial spin-labeling-MR imaging without ionizing radiation or contrast injection with a good correlation to H2[(15)O]-PET after cerebellar normalization. (
  • Although much has been written about moyamoya disease and its treatment, it remains a very unusual disorder, particularly in a middle-aged white adult. (
  • Until recently, cerebral arteriopathy due to heterozygous mutations of the ACTA2 gene was considered a variant of moyamoya disease. (
  • However, radiographic analysis of patients with these mutations reveals a distinctive angiographic appearance from that seen in moyamoya disease. (
  • This article presents a review of the most recent literature on ASL, with a special focus on its use in moyamoya disease, brain neoplasms, seizures, and migraines and a commentary on recent advances in ASL that make the imaging technique more attractive as a clinically useful tool. (
  • In Reply: Early Diffusion Magnetic Resonance Imaging Changes in Normal-Appearing Brain in Pediatric Moyamoya Disease. (
  • however, microatheroma now is thought to be the most common mechanism of arterial occlusion (or stenosis). (
  • BACKGROUND: to study changes involving cerebral vessels in patients with hypertension and various levels of total cardiovascular risk. (
  • He is leading two FDA approved clinical trials, one for intra-arterial chemotherapy for spinal tumors and the other for the treatment of Idiopathic Intracranial Hypertension (pseudotumor cerebri) using angioplasty and stenting . (
  • 2019. Hypertension, antihypertensive use and the delayed onset of Huntington's Disease . (
  • The next day, arterial hypertension and tachycardia developed in the patient. (
  • Recanalized left MCA after 700 000 U intra-arterial urokinase infusion, with total disappearance of the occlusion with normal anterograde flow (arrow). (
  • Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part II. (
  • His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. (
  • The cerebral cortical thickness and cerebral blood flow (CBF), which are considered as morphological and functional image features, respectively, could be decreased in specific cerebral regions of patients with dementia of Alzheimer type. (
  • As the disease progresses, most people with CARASIL also develop mood and personality changes, a decline in thinking ability (dementia), memory loss, and worsening problems with movement. (
  • Binswanger's disease is a type of subcortical vascular dementia caused by white matter atrophy to the brain. (
  • Multiple trials investigating the efficacy of ginkgo for treating cerebrovascular disease and dementia have been performed, and systematic reviews suggest the herb can improve the symptoms of dementia. (
  • Atheroma, embolism, and migraine were the commonest types of underlying vascular disease. (
  • 7,8 Moreover, silent cerebral embolism has also been shown in extracranial angiographic procedures. (
  • Beta-adrenergic binding sites in the cerebral cortex are increased and gamma-aminobutyric acid (GABA) binding sites are decreased. (
  • The corticospinal tract originates from the motor strip of the cerebral cortex. (
  • Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex of Alzheimer's disease (AD) patients several decades ago. (
  • A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. (
  • In a cross-sectional clinical study, we investigated the association of metabolic syndrome with asymptomatic lacunar strokes and cardiovascular disease (CVD) and we compared its significance with urinary protein markers. (
  • PROACT II (Prolyse in Acute Cerebral Thromboembolism II), a randomized, controlled, multicenter, open-label clinical trial with blinded follow-up conducted between February 1996 and August 1998. (
  • This case highlights the importance of early recognition of the angiographic appearance of ACTA2 cerebral arteriopathy and performance of genetic testing, as the location of the mutation impacts clinical presentation and outcomes. (
  • Dr. Patsalides' clinical research interests include the development of new intra-arterial chemotherapy treatments for spinal, and head and neck tumors and novel minimally invasive treatments for spinal tumors. (
  • These tests allow your nutritional assessment for a broad variety of clinical conditions, general wellness and the prevention of chronic diseases including arthritis, cancer, cardiovascular risk, diabetes, various immunological disorders and metabolic disorders. (
  • Binswanger's disease can usually be diagnosed with a CT scan, MRI, and a proton MR spectrography in addition to clinical examination. (
  • PURPOSE: In the absence of a virus nucleic acid real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test and experienced radiologists, clinical diagnosis is challenging for viral pneumonia with clinical symptoms and CT signs similar to that of coronavirus disease 2019 (COVID-19). (
  • To receive news and publication updates for International Journal of Alzheimer's Disease, enter your email address in the box below. (
  • Alzheimer's disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. (
  • ABSTRACT: Alzheimer's disease (AD) is a dementing disorder and one of the major public health problems in countries with greater longevity. (
  • Vascular dysfunction-The disregarded partner of Alzheimer's disease. (
  • A review of the morphological and molecular basis of astrocyte reaction in Alzheimer's disease (AD) will follow next, with special emphasis in its consequences for AD pathophysiology. (
  • 2020. Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity . (
  • 2019. Polygenic impact of common genetic risk loci for Alzheimer's disease on cerebral blood flow in young individuals . (
  • A number of these and more proposed causative agents reportedly inducing or contributing to the deterioration of the nervous system as seen in the physical pathology of the dementias are discussed in Part 1: Alzheimer's Disease Suggested Causes . (
  • The major success reports with Alzheimer's disease I've seen so far seem to point to the central importance of chelating mercury deposits from the body and brain . (
  • Healing Cancer Naturally's pages on Alzheimer's Disease: Causes, Cures & Prevention are a work in progress and continue to be expanded, please check back occasionally. (
  • Cerebral thromboembolism is an uncommon but serious complication of cardiac catheterization. (
  • For arterial emboli, cardiac ultrasound and/or arteriography are ordered. (
  • Cardiac biopsy in Kawasaki disease. (
  • in Parkinson's disease secondary to cerebral arteriosclerosis, the herb increased blood supply to the brain. (
  • arterial sclerosis arteriosclerosis . (
  • Abstract α-Thrombin regulation of endothelial cell (EC) fibrinolysis has been documented by using endothelia derived from a number of anatomic locations but not with those derived from the human cerebral vasculature. (
  • Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. (
  • Anatomical and topographic changes of cerebral vessels were most frequently found in hypertensive patients with high and very high total cardiovascular risk. (
  • We established the relationship between changes in cerebral blood vessels and total cardiovascular risk. (
  • Cerebrovascular disease refers to a group of conditions, diseases, and disorders that affect the blood vessels and blood supply to the brain. (
  • Funded by a Wellcome Trust Senior Research Fellowship, my research focuses on developing MRI-based tools to assess the health of the brain's blood vessels during ageing and disease. (
  • At Texas Health Dallas, patients find care for diseases that affect the blood vessels in the brain and spinal cord. (
  • It has been shown that Binswanger's disease targets the vessels in this zone of the subcortex, but spares the microcirculation's vessels and capillaries which may be attributed to a difference between Alzheimer's and Binswanger's disease. (
  • We examined whether location and progression of white-matter lesions (WMLs), lacunar infarcts and atrophy were associated with motivational and mood symptoms in patients with symptomatic atherosclerotic disease. (
  • 80% success rate in patients with chronic cerebral insufficiency measured by symptoms such as vertigo, headache. (
  • Most affected individuals die within a decade after signs and symptoms first appear, although few people with the disease have survived for 20 to 30 years. (
  • The symptoms of cerebrovascular disease depend on the location of the blockage and its impact on brain tissue. (
  • This table lists symptoms that people with this disease may have. (
  • For most diseases, symptoms will vary from person to person. (
  • People with the same disease may not have all the symptoms listed. (
  • Do you have more information about symptoms of this disease? (
  • Changes in regional brain function may be more dynamic and provide even greater sensitivity to early disease, disease progression, or responses to therapy than changes in regional gray matter volume depicted by structural MRI [ 3 , 4 ]. (
  • The aim of this study was to evaluate the relationship between cognitive impairment and brain perfusion using arterial spin labelling (ASL) in end-stage renal disease (ESRD) patients undergoing PD. (
  • Infectious Diseases of the Brain (S. Muherji). (
  • Structural brain white matter (WM) changes such as axonal caliber, density, myelination, and orientation, along with WM-dependent structural connectivity, may be impacted early in Parkinson disease (PD). (
  • These findings demonstrate that cerebral arterial pulsatility is a key driver of paravascular CSF influx into and through the brain parenchyma, and suggest that changes in arterial pulsatility may contribute to accumulation and deposition of toxic solutes, including amyloid β, in the aging brain. (
  • The cerebral blood flow (CBF) maps derived from 3D ASL were coregistered to the Montreal Neurological Institute brain space. (
  • [email protected]#The decreased absolute cerebral blood perfusion involved not only subcortical regions, but also the whole brain level in the course of PD. (
  • Stabilizing the membranes of the blood-brain barrier which are thought to involve a direct impact on ionic balance across the membranes and an indirect effect on intracellular respiration, lessening cerebral edema and restoring function. (
  • My main goal is to provide exceptional patient care in the diagnosis and treatment of complex diseases of the brain and spine. (
  • These findings suggest the possibility that the cerebral microvasculature may be a specialized region of the vascular system in which urokinase-type plasminogen activator, not tissue-type plasminogen activator, is the key catalyst of fibrin lysis when the brain responds to thrombotic events and that α-thrombin may regulate repair of the cerebral microvascular system. (
  • tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain ( tubers ), retina ( phakomas ), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions. (
  • Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI). (
  • Because T1 blood depends on hematocrit in healthy individuals, we investigated the importance of measuring T1 blood in vivo with MR imaging versus calculating it from hematocrit or assuming an adult fixed value recommended by the literature, hypothesizing that measured T1 blood would be the most suited for CBF quantification in children with sickle cell disease. (
  • To this end, we performed a comprehensive proteomic analysis of blood plasma, with the scope to identify disease-associated changes after placing them in the context of existing knowledge, and generate a well characterized dataset for further use in CVD multi-omics integrative analysis. (
  • The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure. (
  • Cardiovascular effect of cyclooxygenase inhibitors on cerebral, vascular, blood pressure and homeostatic responses following chronic intermittent hypoxia exposure. (
  • The cerebral blood flow will be mesauresed during each testing days of all three protocols. (
  • [email protected]#To investigate alterations of blood perfusion in subcortical regions in patients with Parkinson′s disease (PD) by three dimentional arterial spin labeling (ASL) magnetic resonance imaging (MRI). (
  • ISMRM 2009) Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease Using 3D Spiral SE Arterial Spin Labeling on 3T-MR: Correlative Study with O15 Labeled H2O PET Examination. (
  • Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment that provides a quantitative map of cerebral blood flow. (
  • Geerlings, M.I. / Hemoglobin, hematocrit, and changes in cerebral blood flow: the Second Manifestations of ARTerial disease-Magnetic Resonance study . (
  • microcirculation in the conjunctiva of patients with disturbances in cerebral blood supply consistently increased. (
  • It is suggested that this is due to collateral blood flow reaching the margins of the posterior cerebral territory from the adjacent middle cerebral territory via pial anastomoses. (
  • Arterial spin labeling (ASL) is an imaging modality that permits the examination of blood flow and perfusion without the need for contrast injection. (
  • A rterial spin labeling (ASL) is a neuroimaging technique that noninvasively quantifies cerebral blood flow (CBF). (
  • Narrows arterial opening, restricts blood flow. (
  • Blood pressure, body mass index and cigarette smoking were associated with the age of death and mortality due to cardiovascular disease, lung cancer and respiratory system diseases. (
  • However, known risk factors such as high blood pressure ( 7 ), high body mass index (BMI) ( 8 ) and cigarette smoking ( 9 ) were associated with a higher risk of ischaemic heart disease ( 2 , 3 ). (
  • Arterial emboli are usually a complication of heart disease where blood clots form in the heart's chambers. (
  • Mean arterial blood pressure and neonatal cerebral lesions. (
  • Balloon valvuloplasty is not quite as high calculi are associated with arterial blood (pao4), but have not one should be considered. (
  • 2019. Cerebral autoregulation evidence by synchronized low frequency oscillations in blood pressure and resing-state fMRI . (
  • 2019. Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI . (
  • For those with cerebrovascular or neurovascular disease, blood flow is temporarily or permanently affected. (
  • 1 On the other hand, positron emission tomography and single-photon emission computed tomography or transcranial Doppler combined with a vasodilator have been used for functional assessment of LMC by measuring the autoregulatory capacity of cerebral blood flow or cerebrovascular reserve (CVR). (
  • CKD stage 5, which requires dialysis or renal transplantation, is known as end-stage renal disease (ESRD). (
  • Exclusion criteria were previously diagnosed OSA syndrome, congestive heart failure, atrial fibrillation or any other nonsinus rhythm, inability to co-operate, immobility, end-stage renal disease, history of coronary bypass within 3 yrs, or other major surgery within 3 months prior to enrolment. (
  • The effect of renal disease on the disposition of Aurovela Fe 1/20 has not been evaluated. (
  • Cerebral Vascular Venous Lesions (S. Muherji). (
  • Vascular Lesions of Collagen Diseases and Related Conditions. (
  • 40% success in elderly patients with arterial insufficiency of lower limbs. (
  • Effects of birth weight, gestational age, and maternal obstetric history on birth prevalence of cerebral palsy. (
  • Trends in birth prevalence of cerebral palsy. (
  • In this study, we examined the relationship between the degree of LMC and the flow change with Diamox challenge measured using QMRA, hypothesizing that these flow changes correlate with indicators of impaired CVR and thus may be used to evaluate CVR in steno-occlusive disease. (
  • Quantitative correlation of relative CBF with cerebellar normalization between arterial spin-labeling-MR imaging and H 2 [ 15 O]-PET was evaluated in a volume-based approach for each vascular territory after 3D image coregistration. (
  • Children with sickle cell disease have low hematocrit and elevated CBF, the latter of which can be assessed with arterial spin-labeling MR imaging. (
  • Functional CBF maps were measured with an arterial spin labeling technique, and ten regional CBF values were obtained by registration between the CBF map and Talairach atlas using an affine transformation and a free form deformation. (
  • One hundred fifty diagnostic cerebral angiographies were randomized into 50 procedures, each using conventional angiographic technique, or systemic heparin treatment throughout the procedure, or air filters between the catheter and both the contrast medium syringe and the catheter flushing. (
  • 2019. Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity . (
  • End-to-end automatic differentiation of the coronavirus disease 2019 (COVID-19) from viral pneumonia based on chest CT. (
  • In 578 patients [63 (s.d.=8) years] of the Second Manifestations of ARTerial disease (SMART)-Medea study, volumes of WMLs and atrophy and visually rated infarcts were obtained with 1.5 T magnetic resonance imaging at baseline and after 3.9 (s.d.=0.4) years' follow-up. (
  • Fukutake T. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification. (
  • 65% successful treatment of focal or diffuse cerebral vascular disease. (
  • diffuse cerebral sclerosis the infantile form of metachromatic leukodystrophy. (
  • A repeat CT scan showed a lesion in the right frontal lobe and diffuse cerebral edema ( Figure 1A ). (
  • 2020. A frequency-domain machine learning method for dual-calibrated fMRI mapping of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2) . (
  • Calcific cerebral arterial embolization in the setting of bacterial endocarditis superimposed on prior rheumatic aortic valvular disease. (
  • Previous studies have suggested that DTI metrics are sensitive in capturing early disease-associated WM changes in preclinical symptomatic regions such as olfactory regions and the substantia nigra, which is considered to be a hallmark of PD pathology and progression. (
  • Fujiwara H, Hamashima Y: Pathology of the heart in Kawasaki disease. (
  • Association of Memory Impairment With Concomitant Tau Pathology in Patients With Cerebral Amyloid Angiopathy. (