Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
Acquiring information from a patient on past medical conditions and treatments.
A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)
Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.
INFLAMMATION of any ARTERIES.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
An alkylating agent of value against both hematologic malignancies and solid tumors.
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
Hospital department responsible for the administration and management of nuclear medicine services.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Books containing photographs, prints, drawings, portraits, plates, diagrams, facsimiles, maps, tables, or other representations or systematic arrangement of data designed to elucidate or decorate its contents. (From The ALA Glossary of Library and Information Science, 1983, p114)
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
The study of natural phenomena by observation, measurement, and experimentation.
Libraries in which a major proportion of the resources are available in machine-readable format, rather than on paper or MICROFORM.
A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.
Acquisition, organization, and preparation of library materials for use, including selection, weeding, cataloging, classification, and preservation.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. The tumor may present clinically with HORNER SYNDROME or diarrhea due to ectopic production of vasoactive intestinal peptide. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p966)
A hereditary disease characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions. Individuals with this syndrome have a high risk of BREAST CANCER; THYROID CANCER; and ENDOMETRIAL CANCER. This syndrome is associated with mutations in the gene for PTEN PHOSPHATASE.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
A functional relationship between psychological phenomena of such nature that the presence of one tends to evoke the other; also, the process by which such a relationship is established.
The relationships between symbols and their meanings.
Lists of words to which individuals are asked to respond ascertaining the conceptual meaning held by the individual.
An encapsulated lymphatic organ through which venous blood filters.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. (1/828)

PURPOSE: From 1986 to 1992, "eight-drugs-in-one-day" (8-in-1) chemotherapy both before and after radiation therapy (XRT) (54 Gy tumor/36 Gy neuraxis) was compared with vincristine, lomustine (CCNU), and prednisone (VCP) after XRT in children with untreated, high-stage medulloblastoma (MB). PATIENTS AND METHODS: Two hundred three eligible patients with an institutional diagnosis of MB were stratified by local invasion and metastatic stage (Chang T/M) and randomized to therapy. Median time at risk from study entry was 7.0 years. RESULTS: Survival and progression-free survival (PFS) +/- SE at 7 years were 55%+/-5% and 54%+/-5%, respectively. VCP was superior to 8-in-1 chemotherapy, with 5-year PFS rates of 63%+/-5% versus 45%+/-5%, respectively (P = .006). Upon central neuropathology review, 188 patients were confirmed as having MB and were the subjects for analyses of prognostic factors. Children aged 1.5 to younger than 3 years had inferior 5-year estimates of PFS, compared with children 3 years old or older (P = .0014; 32%+/-10% v 58%+/-4%, respectively). For MB patients 3 years of age or older, the prognostic effect of tumor spread (MO v M1 v M2+) on PFS was powerful (P = .0006); 5-year PFS rates were 70%+/-5%, 57%+/-10%, and 40%+/-8%, respectively. PFS distributions at 5 years for patients with M0 tumors with less than 1.5 cm2 of residual tumor, versus > or = 1.5 cm2 of residual tumor by scan, were significantly different (P = .023; 78%+/-6% v 54%+/-11%, respectively). CONCLUSION: VCP plus XRT is a superior adjuvant combination compared with 8-in-1 chemotherapy plus XRT. For patients with M0 tumors, residual tumor bulk (not extent of resection) is a predictor for PFS. Patients with M0 tumors, > or = 3 years with < or = 1.5 cm2 residual tumor, had a 78%+/-6% 5-year PFS rate. Children younger than 3 years old who received a reduced XRT dosage had the lowest survival rate.  (+info)

Hemangioblastoma mimicking tentorial meningioma: preoperative embolization of the meningeal arterial blood supply--case report. (2/828)

A 72-year-old male presented with a primary hemangioblastoma of the posterior fossa with unusual dural attachment and meningeal arterial blood supply from the external carotid artery and marginal tentorial artery. Preoperative embolization facilitated complete resection of the tumor with no resultant neurological deficit. Hemangioblastoma must be included in the differential diagnosis of tumors with dural involvement. Preoperative embolization is very useful in such tumors.  (+info)

Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells. (3/828)

Chemotherapeutic agents and gamma-irradiation used in the treatment of brain tumors, the most common solid tumors of childhood, have been shown to act primarily by inducing apoptosis. Here, we report that activation of the CD95 pathway was involved in drug- and gamma-irradiation-induced apoptosis of medulloblastoma and glioblastoma cells. Upon treatment CD95 ligand (CD95-L) was induced that stimulated the CD95 pathway by crosslinking CD95 via an autocrine/paracrine loop. Blocking CD95-L/receptor interaction using F(ab')2 anti-CD95 antibody fragments strongly reduced apoptosis. Apoptosis depended on activation of caspases (interleukin 1beta-converting enzyme/Ced-3 like proteases) as it was almost completely abrograted by the broad range caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone. Apoptosis was mediated by cleavage of the receptor proximal caspase FLICE/MACH (caspase-8) and the downstream caspase CPP32 (caspase-3, Apopain) resulting in cleavage of the prototype caspase substrate PARP. Moreover, CD95 was upregulated in wild-type p53 cells thereby increasing responsiveness towards CD95 triggering. Since activation of the CD95 system upon treatment was also found in primary medulloblastoma cells ex vivo, these findings may have implications to define chemosensitivity and to develop novel therapeutic strategies in the management of malignant brain tumors.  (+info)

Cicatricial fibromatosis mimics metastatic medulloblastoma. (4/828)

Cicatricial fibromatoses usually occur in the anterior abdominal wall or in the extremities, but rarely in the scalp or the soft tissues of the neck. We report a case of desmoid fibromatosis that developed in a 15-year-old boy 8 months after surgery for cerebellar medulloblastoma.  (+info)

Unexpected stomach uptake of technetium-99m-MDP. (5/828)

Two pediatric cases are described in which the results of each patient's bone scan demonstrated abnormal stomach uptake. There have been a number of reports in the literature describing stomach uptake of bone agents, however, it is an uncommon finding.  (+info)

Clinical features and outcomes in patients with non-acoustic cerebellopontine angle tumours. (6/828)

OBJECTIVES: Non-acoustic tumours of the cerebellopontine angle differ from vestibular schwannomas in their prevalence, clinical features, operative management, and surgical outcome. These features were studied in patients presenting to the regional neuro-otological unit. METHODS: A retrospective analysis of clinical notes identified 42 patients with non-acoustic tumours of the cerebellopontine angle. Data were extracted regarding presenting clinical features, histopathological data after surgical resection, surgical morbidity and mortality, and clinical outcome (mean 32 months follow up). RESULTS: The study group comprised 25 meningiomas (60%), 12 epidermoid cysts/cholesteatomata (28%), and five other tumours. In patients with meningiomas, symptoms differed considerably from patients presenting with vestibular schwannomas. Cerebellar signs were present in 52% and hearing loss in only 68%. Twenty per cent of patients had hydrocephalus at the time of diagnosis. After surgical resection, normal facial nerve function was preserved in 75% of cases. In the epidermoid group, fifth, seventh, and eighth nerve deficits were present in 42%, 33%, and 66% respectively. There were no new postoperative facial palsies. There were two recurrences (17%) requiring reoperation. Overall, there were two perioperative deaths from pneumonia and meningitis. CONCLUSIONS: Patients with non-acoustic lesions of the cerebellopontine angle often present with different symptoms and signs from those found in patients with schwannomas. Hearing loss is less prevalent and cerebellar signs and facial paresis are more common as presenting features. Hydrocephalus is often present in patients presenting with cerebellopontine angle meningiomas. Non-acoustic tumours can usually be resected with facial nerve preservation.  (+info)

Medullomyoblastoma: A case report. (7/828)

Medullomyoblastoma is a rare tumour seen in childhood. We report a medullomyoblastoma occurring in the cerebellar vermis of a 4 year old boy. The light microscopic features, immunohistochemistry and histogenesis are described.  (+info)

Choroid plexus papilloma of cerebellopontine angle with extension to foramen magnum. (8/828)

A case of choroid plexus papilloma resembling meningioma of cerebellopontine (CP) angle with its extension to foramen magnum is presented. Occurrence of this tumour in CP angle is very rare. Its extension towards foramen magnum is further rare. It was a real diagnostic enigma preoperatively as the tumour was resembling meningioma upto some extent on radiological study. Retromastoid craniectomy with microsurgical excision of tumour and its extension was achieved in toto. Tumour was attached to few rootlets of lower cranial nerves which were preserved. Attachment of the tumour with lower cranial nerves again caused diagnostic confusion with neurofibroma intraoperatively.  (+info)

Cerebellar Neoplasms; Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar Neoplasms. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Univariate analysis showed total FIM-FAM scores not significantly different with age (, or =35 years vs. ,35 years; P = 0.994), sex (male versus female; P = 0.133), and grade of the tumor (high-grade versus low-grade; P = 0.142) but were significantly higher in patients with a Karnofsky performance score (KPS) of , or =70 as compared with ,70 (P = 0.001), neurological performance scale (NPS) of 0 or 1 vs. 2 or 3; P = 0.001), disease type (benign versus malignant; P = 0.001), and site of disease (cerebral versus cerebellar; P = 0.024 ...
At the same time discount suprax 100mg without prescription antibiotic resistance research funding, two other fissures deep- en on the inferior aspect of the vermis purchase suprax 100 mg with visa bacteria 2014, the secondary fissure and the prepyramidal fissure discount arava 10 mg overnight delivery, limiting the uvula and the pyramid respectively. Meanwhile the cerebellar mass, especially the cerebellar hemi- spheres, develops to cover the inferior vermis, which becomes buried deeply within the vallecula. Phylogenetically and ontogenetically, the postero- lateral fissure is the first to appear, separating the flocculonodular lobe, which is constant in most ver- tebrates, from the cerebellar mass, which increases in size from lower to higher vertebrates. Posteriorly and in- flocculus of mammals is the homologue of the hu- feriorly a narrow median fossa, the vallecula cerebel- man tonsil and the biventer lobule of the human cer- li, separates the hemispheres and contains the falx ebellum. ...
Source. Diagnosis. In case you feel that something can be wrong with your health, schedule an appointment with your doctor. The physician will ask you about your symptoms and in case he has reasons to suspect that you may suffer from a cerebellar condition, you will be referred to a neurologist. This specialist will test reflexes, as well as hearing and vision. A magnetic resonance imaging test, as well as a computerized tomography may be recommended to confirm the suspicion in the diagnosing process. Additional tests may be performed with the purpose to measure the tumors activity, as well as to determine if it is cancerous or not.. Treatment. In most cases, specialists are going to recommend the surgical removal of the tumor found in the cerebellum. In case the tumor has started to spread, it can only be partially removal or may cause additional damage to the body, radiation and chemotherapy can also be recommended.. ...
HPLC-MS/MS phosphoproteomics Analysis of human medulloblastoma cell line (DAOY cell line). 15 minutes treatment with SAG, vismodegib, EGF. TMT 10 plex experiment. 13 HILIC fractions measured using Qexactive HF. Knime Workflow. ...
Medulloblastoma (MB) is the most common malignant childhood brain tumor and high neurotrophin (NP) receptor TrkC mRNA expression was identified as a powerful independent predictor of favorable survival outcome. In order to determine downstream effector proteins of TrkC signaling, the MB cell line DAOY was stably transfected with a vector containing the full-length TrkC cDNA sequence or an empty vector control. A proteomic approach was used to search for expressional changes by two mass spectrometric methods and immunoblotting for validation of significant results. Multiple time points for up to 48 h following NP-3-induced TrkC receptor activation were chosen. Thirteen proteins from several pathways (nucleoside diphosphate kinase A, stathmin, valosin-containing protein, annexin A1, dihydropyrimidinase-related protein-3, DJ-1 protein, glutathione S-transferase P, lamin A/C, fascin, cofilin, vimentin, vinculin, and moesin) were differentially expressed and most have been shown to play a role in ...
A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).
This article collates information about the number of scientific articles mentioning each of the established medulloblastoma cell lines, derived through a systematic search of Web of Science, Scopus and Google Scholar in 2016. The data for each cell line have been presented as raw number of citations, percentage share of the total citations for each search engine and as an average percentage between the three search engines. In order to correct for the time since each cell line has been in use, the raw citation data have also been divided by the number of years since the derivation of each cell line. This is a supporting article for a review of in vitro models of medulloblastoma published in in vitro models of medulloblastoma: choosing the right tool for the job (D.P. Ivanov, D.A. Walker, B. Coyle, A.M. Grabowska, 2016) [1].. ...
Inhibiting the Ezh2 enzyme may be counterproductive for treatment of certain cancers, including the aggressive brain tumor Group 3 medulloblastoma
Constitutive phosphorylation of Chk1 at serine 317 in a medulloblastoma cell line is sensitive to the inhibition of the phosphatidyalinositol-3-kinase-related kinase (PIKK) pathway
It is demonstrated that OTX2 is essential in medulloblastoma and directly drives proliferation by regulation of cell cycle genes. The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. To study the role OTX2 has in medulloblastoma we investigated the downstream pathway of OTX2. We generated D425 medulloblastoma cells in which endogenous OTX2 can be silenced by inducible shRNA. Silencing of OTX2 strongly inhibited cell proliferation and resulted in a neuronal‐like differentiation. Expression profiling of time courses after silencing showed a progressive change in gene expression for many cellular processes. Downregulated genes were highly enriched for cell cycle and visual perception genes, while upregulated genes were enriched for genes involved in development and differentiation. This shift is reminiscent of expression changes
The goal of the Johns Hopkins Brain Cancer Biology and Therapy Laboratory is to locate the genetic and genomic changes that lead to brain cancer. These molecular changes are evaluated for their potential as therapeutic targets and are often mutated genes, or genes that are over-expressed during the development of a brain cancer. The brain cancers that the Riggins Laboratory studies are medulloblastomas and glioblastomas. Medulloblastomas are the most common malignant brain tumor for children and glioblastomas are the most common malignant brain tumor for adults. Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. Our laboratory uses large-scale genomic approaches to locate and analyze the genes that are mutated during brain cancer development. The technologies we now employ are capable of searching nearly all of a cancer genome for molecular alterations that can lead to cancer. The new molecular targets for cancer therapy are first located by l...arge ...
PRIMARY OBJECTIVES:. I. Estimate of the progression free survival (PFS) distribution for patients 0-,4 years of age with M0 desmoplastic medulloblastoma (nodular desmoplastic or medulloblastoma with extensive nodularity) treated with the modified HIT SKK regimen (excluding the use of intraventricular methotrexate).. SECONDARY OBJECTIVES:. I. Evaluate the feasibility of a rapid central pathology screening review for treatment allocation according to histology and assess agreement between institutional and central pathology review diagnoses as well as among central pathology review diagnoses.. II. Prospectively evaluate the molecular profile of nodular desmoplastic (ND)/medulloblastoma with extensive nodularity (MBEN) medulloblastoma in young children.. III. Monitor and describe the neurocognitive and adaptive functioning of young children with ND/MBEN medulloblastoma treated on this protocol using the ALTE07C1 protocol.. OUTLINE:. INDUCTION THERAPY: Patients receive vincristine sulfate ...
Published June 2015. ISBN: 978-1-78084-396-4. Medulloblastomas are highly malignant cerebellar tumors. Approximately 80% of medulloblastomas are diagnosed in children younger than 15 years of age, and they are among the leading causes of pediatric cancer deaths. Remarkable advances in survival have been achieved in the past two decades using a combination of surgery, chemotherapy, radiation and bone marrow rescue. However, this improvement in outcome is attained at a high cost to quality of life due to the aggressive treatment regimens, and many patients succumb to their disease and/or its recurrence. The five chapters of this book provide a comprehensive, but straightforward, up-to-date reference for medical students, residents and fellows, and other healthcare professionals, as well as basic science researchers with an interest in pediatric medulloblastomas.. ...
Medulloblastomas are highly malignant cerebellar tumors. Approximately 80% of medulloblastomas are diagnosed in children younger than 15 years of age, and they are among the leading causes of pediatric cancer deaths. Remarkable advances in survival have been achieved in the past two decades using a combination of surgery, chemotherapy, radiation and bone marrow rescue. However, this improvement in outcome is attained at a high cost to quality of life due to the aggressive treatment regimens, and many patients succumb to their disease and/or its recurrence. The five chapters of this book provide a comprehensive, but straightforward, up-to-date reference for medical students, residents and fellows, and other healthcare professionals, as well as basic science researchers with an interest in pediatric medulloblastomas.. ...
Medulloblastomas are the most common malignant brain tumours in children. Identifying and understanding the genetic events that drive these tumours is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct molecular subtypes of medulloblastoma on the basis of transcriptional and copy number profiles. Here we use whole-exome hybrid capture and deep sequencing to identify somatic mutations across the coding regions of 92 primary medulloblastoma/normal pairs. Overall, medulloblastomas have low mutation rates consistent with other paediatric tumours, with a median of 0.35 non-silent mutations per megabase. We identified twelve genes mutated at statistically significant frequencies, including previously known mutated genes in medulloblastoma such as CTNNB1, PTCH1, MLL2, SMARCA4 and TP53. Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, ...
TY - JOUR. T1 - Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line. AU - Henderson, Jacob J.. AU - Wagner, Jacob P.. AU - Hofmann, Nicolle E.. AU - Eide, Christopher A.. AU - Cho, Yoon-Jae. AU - Druker, Brian. AU - Davare, Monika. PY - 2017. Y1 - 2017. N2 - Medulloblastoma is the most common malignant brain tumor of childhood. To identify targetable vulnerabilities, we employed inhibitor screening that revealed mTOR inhibitor hypersensitivity in the MYC-overexpressing medulloblastoma cell line, D341. Concomitant exome sequencing unveiled an uncharacterized missense mutation, TSC2A415V, in these cells. We biochemically demonstrate that the TSC2A415V mutation is functionally deleterious, leading to shortened half-life and proteasome-mediated protein degradation. These data suggest that MYC cooperates with activated kinase pathways, enabling pharmacologic intervention in these treatment ...
Daniel RA, Rozanska AL, Mulligan EA, Drew Y, Thomas HD, Castelbuono DJ, Hostomsky Z, Plummer ER, Tweddle DA, Boddy AV, Clifford SC, Curtin ...
Developing new, less toxic approaches to treatment is critical to advancing therapy for medulloblastoma, the most common malignant brain tumor in children. While many medulloblastoma patients achieve long-term survival through combined radiation and chemotherapy, this treatment causes long-term neuro-cognitive impairment and significant risk of incurable recurrence. The early age of onset of medulloblastoma has prompted a growing consensus to examine the processes that support developmental brain growth as potential oncogenic mechanisms that may be targeted in novel therapies. Our recent work demonstrates that energy metabolism, DNA repair and control of apoptosis are developmentally regulated to support proliferation during cerebellar growth, and become co-opted in medulloblastoma formation. Our ongoing projects build on these observations, using mouse genetics and primary tumor modeling to learn:. ...
Treatment of pediatric medulloblastoma, the most common malignant tumor of the CNS in children, requires a combination of surgical excision, radiation therapy, and chemotherapy. Prior research has documented ototoxicity and middle ear disease in 25% to 90% of patients treated with multimodality therapy.5, 7, 11 At this institution, pediatric medulloblastoma patients receive a cumulative cisplatin dose of 300 mg, decreased from the standard of 600 mg. Early analysis suggests that this reduction may minimize ototoxic sequelae, however long-term data on SNHL is lacking. Further, the percentage of patients in this population that will ultimately qualify for cochlear implantation has not yet been documented.. Damage to the auditory system from chemotherapeutic agents, specifically platinum-based compounds, as well as radiation therapy is well documented. Cisplatinum ototoxicity is typically characterized by irreversible, bilateral, symmetric, high-frequency SNHL.5, 7 Ototoxicity can be related to ...
Assuming that the fundamental feature of cancer is genomic instability, functional defects of proteins which are responsible for maintenance of genome integrity by correcting DNA replication errors, should be carcinogenic. It is therefore not surprising that a number of cancer susceptibility genes encode key factors of DNA repair pathways. Recent comprehensive analysis of germline mutations in pediatric cancers pointed to DNA repair genes as the most commonly mutated genes, including TP53 and BRCA2 [43]. It is also increasingly clear that defects in DNA repair genes may determine patients response to radio and chemotherapy [13, 16, 17]. In view of that we evaluated the potential association between DNA repair defects and treatment related toxicity as well as their potential role as a susceptibility factor for medulloblastoma.. The sequence analysis of two well-known repair genes MSH2 and RAD50 conducted in large cohort of 102 medulloblastoma patients revealed three new germline variants MSH2 ...
Investigators at St. Jude Childrens Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor.
3885 Medulloblastomas are malignant brain tumors that arise in the cerebellum in children. Aberrant activation of the Sonic Hedgehog (Shh) signaling pathway, which normally stimulates proliferation of granule neuron precursors (GNPs) during cerebellar development, induces tumors in mice that closely mimic human medulloblastomas. Shh-dependent medulloblastoma formation is enhanced by hyperactive insulin-like growth factor (IGF) signaling and ectopic expression of Myc oncogenes. This enhanced tumorigenesis stems from the sensitivity of GNPs to IGF and Myc levels in regulating proliferation. An emerging theme in cancer research is that oncogene-induced cell proliferation cannot initiate neoplastic transformation unless cellular programs that mediate apoptosis are disabled. We modeled the ability of the anti-apoptotic protein Bcl-2 to induce medulloblastoma in vivo using the RCAS/tv-a system, which allows postnatal gene transfer and expression in a cell type-specific manner. We targeted expression ...
Medulloblastoma is the most common malignant brain tumor of childhood. Improvements in clinical outcome require a better understanding of the genetic alterations to identify clinically significant biological factors and to stratify patients accordingly. In the present study, we applied cytogenetic characterization to guide the identification of biologically significant genes from gene expression microarray profiles of medulloblastoma. We analyzed 71 primary medulloblastomas for chromosomal copy number aberrations (CNAs) using comparative genomic hybridization (CGH). Among 64 tumors that we previously analyzed by gene expression microarrays, 27 were included in our CGH series. We analyzed clinical outcome with respect to CNAs and microarray results. We filtered microarray data using specific CNAs to detect differentially expressed candidate genes associated with survival. The most frequent lesions detected in our series involved chromosome 17; loss of 16q, 10q, or 8p; and gain of 7q or 2p. Recurrent
Medulloblastoma is the most common malignant pediatric brain tumor. While current treatments have improved survival, survivors face high risk of recurrence and...
TY - JOUR. T1 - Ultrastructure of cerebellar hemangioblastoma - Some new observations on the stromal cells. AU - Shimura, T.. AU - Hirano, A.. AU - Llena, J. F.. PY - 1985/3. Y1 - 1985/3. N2 - Five cases of hemangioblastoma were studied by electron microscopy with particular attention to the stromal cells and their surrounding structures. Most of the stromal cells of the tumor had abundant clear cytoplasm containing rough endoplasmic reticulum, mitochondria, scattered fibrils, and large lipid inclusions. They were usually aggregated without intervening cells. In the perivascular areas, their sufaces facing the perivascular collagen were surrounded by basal lamina. Their apposed cell membranes had occasional adhesive devices. Occasional, long, apparently cylindrical processes of the stromal cell cytoplasm were observed in some cases. These processes contained intermediate filaments of undetermined nature and microtubules. In the border zone between the tumor and the surrounding brain, the stromal ...
Medulloblastoma occurs in infants, children and adults, but it is the most common malignant pediatric brain tumor, of which Group 4 is the most common.
Gurreiro, A. Iidentification of new molecular targets for human medulloblastoma using an RNA interference screen. 2009, University of Zurich, Faculty of Medicine. ...
View Notes - DIAG 2740 Chapter 15 Outline from DIAG 2740 at Life Chiropractic College West. SCA infarct: PICA and AICA: Cerebellar tumor: Medulloblastoma Signs: Cerebellar Multiple Sclerosis
Medulloblastoma, a highly invasive tumour of the cerebellum, has one of the highest mortality rates of pediatric cancers. Metastatic cells are the leading cause of treatment failure and death in medulloblastoma patients. For over a century, scientists assumed that medulloblastoma metastases travel exclusively in cerebrospinal fluid; however, novel research shows that medulloblastoma can spread through the circulatory system as well. This new mechanism presents the first biological target for metastases; therefore, the dissemination of this research is critical to the development of therapies, disease management, and prognosis. An educational 3D animation can effectively disseminate this research, as well as increase awareness and interest in medulloblastoma. A story-driven narrative and emphasis on the use of visual metaphor will put the research in context by establishing why this research matters, what the future implications are, and how it is relevant to the audience.. ...
Laboratory for Childhood Brain Tumor Research. Medulloblastoma is the most common malignant brain tumor in children and one of the leading causes of death in this age group. Over one-third of children with medulloblastoma die within 5 years of diagnosis and the vast majority of survivors have significant neurological deficits due to the toxicity of combined surgery, radiation, and chemotherapy. To improve survival and minimize side effects of current therapy, a more detailed understanding of the biology of medulloblastoma will better characterize the disease and will aid in prognosis and in identification of novel treatments.. Cancer, in general, is a disease that is believed to originate sporadically from one or a few cells within a tissue. After a cell acquires genetic mutations over time, the cell then has a growth advantage over normal surrounding cells in the tissue, and has the potential to become cancerous. Current mouse models of cancer, including those for medulloblastoma, have been ...
Tumors within the cerebellum of the brain can be malignant or benign. This is often a secondary site for metastasis from other cancers, including lung and breast cancer. Symptoms of cerebellar tumors include ataxia and intracranial hypertension. Here is the latest research on cerebellar neoplasms. ...
In chick chorioallantoic membrane (CAM) assays, injection of cilengitide into CAM vasculature prevented the growth of implanted U87MG glioma and DAOY medulloblastoma tumor fragments compared to the inactive peptide EMD135981. The inhibition of tumor growth was attributed to the anti-angiogenic activity of cilengitide as membrane vascularity surrounding the tumor graft was greatly decreased by cilengitide treatment as compared to the inactive control peptide [130]. In animal models, cilengitide, as a single agent effectively inhibited the growth and proliferation of orthotopically implanted malignant glioma and medulloblastoma cell lines in nude mice. Daily treatment of established xenografts with 100-200 µg cilengitide significantly delayed tumor growth and prolonged survival compared to controls. The delayed tumor growth was accompanied by increases in CD31 and tumor doubling times, elevated apoptotic index and decreases in proliferative index and tumor vessel number and density [130]. ...
A major goal of our work is to study medulloblastoma biology to facilitate the development of targeted therapy. Here, we have dissected the contribution of epigenetics to tumor development. Epigenetic perturbations are pharmacologically reversible and may have therapeutic potential. The RE1-Silencing Transcription Factor (REST) is an epigenetic modulator, and a repressor of neuronal differentiation genes. Its expression is significantly elevated in human medulloblastomas, and is associated with poor prognosis. REST is a driver of medulloblastoma in mouse orthotopic models. To understand RESTs contribution to tumor development, we created a novel genetically engineered mouse model in which REST transgene is conditionally elevated in the cerebellar granule progenitors (GNPs), the cells of origin of some medulloblastoma. Transgene induction caused GNP hyperproliferation, accompanied by a failure to express the cell cycle regulator-p27. Using genetic and biochemical approaches, we attributed the ...
INTRODUCTION. Seeding of cerebrospinal fluid (CSF) and leptomeninges by human tumor cells is associated with hydrocephalus and poor prognosis. CSF tumor spread is most commonly found in breast carcinoma in adults, and medulloblastoma in children. We evaluated breast cancer and medulloblastoma leptomeningeal (LM) tumor models as assessed by magnetic resonance imaging (MRI), histology, and survival. METHODS. MDA-MB231BR human breast carcinoma cells expressing HER2 (1 x 106 cells) and DAOY human medulloblastoma cells (1.5 x 106 or 5 x 106) were injected into the right lateral cerebral ventricle or the cisterna magna of adult female or male nude rats, respectively. Animals underwent weekly MRI (T2-weighted and T1-weighted with or without gadolinium). Ventricular volume and ventricular/cerebral ratio were measured as markers of hydrocephalus. Rat brains were harvested 1-4 weeks after tumor cell injection, or followed for survival, and coronal sections were evaluated by histology and ...
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC. Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. The Lancet Oncology 2017, 18(7), 958-971 ...
The quest to improve survival of children with a high-risk brain tumor has led investigators at St. Jude Childrens Research Hospital to two drugs already used to treat adults with breast, pancreatic, lung, and other cancers. The study by Morfouace at al was published today in Cancer Cell. Researchers demonstrated that combination pemetrexed (Alimta) and gemcitabine was effective against mouse and human group 3 medulloblastoma cells. Of the four distinct medulloblastoma subtypes, patients with group 3 medulloblastoma have the worst prognosis.. Used together, pemetrexed and gemcitabine doubled life expectancy of mice with human group 3 medulloblastoma, compared to untreated mice. When pemetrexed and gemcitabine were combined with two chemotherapy drugs currently used to treat pediatric medulloblastoma, the mice lived even longer.. Study Details. The drugs were identified by screening the St. Jude library of 7,389 compounds looking for ones that targeted group 3 mouse tumor cells rather than ...
Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of …
Medulloblastoma, an aggressive cancer of the cerebellum, is among the most common pediatric brain tumors. Approximately one-third of medulloblastomas are associated with misactivation of the Hedgehog (Hh) pathway. GLI family zinc finger 2 (GLI2) coordinates the Hh transcriptional program; however, the GLI2 targets that promote cancer cell proliferation are unknown. Here, we incorporated a Gli2-EGFP allele into 2 different genetic mouse models of Hh-associated medulloblastoma. Hh signaling induced GLI2 binding to the Cdk6 promoter and activated Cdk6 expression, thereby promoting uncontrolled cell proliferation. Genetic or pharmacological inhibition of CDK6 in mice repressed the growth of Hh-associated medulloblastoma and prolonged survival through inhibition of cell proliferation. In human medulloblastoma, misactivation of Hh signaling was associated with high levels of CDK6, pointing to CDK6 as a direct transcriptional target of the Hh pathway. These results suggest that CDK6 antagonists may be ...
Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive therapy, many patients succumb to the disease, and survivors experience severe side effects from treatment. MYC-driven MB has a particularly poor prognosis and would greatly benefit from more effective therapies. We …
LY2940680 administered orally once daily at escalating doses (92.5 milligrams per square meter [mg/m^2] up to 370 mg/m^2) for two 28 day cycles. Lower dose levels (23 mg/m^2 and 46 mg/m^2) may also be explored, if necessary. Participants receiving benefit may continue until disease progression, unacceptable toxicity, or discontinuation ...
To analyse the histo-morphology of cases of medullomyoblastoma and identifying its divergent differentiation. A retrospective review of all cases reported as medulloblastoma between the period of Jan 2000 to Dec 2006 was carried out on Hematoxylin and eosin (H & E) stained slides. The cases were screened on light microscopy for primitive neuroectodermal component of a medulloblastoma accompanied by areas of myoid differentiation, identified on the basis of presence of strap cells (indicating a clear skeletal muscle differentiation) and/or large anaplastic cells with vescicular nuclei and moderate to abundant amount of eosinophilic cytoplasm. All these cases were subjected to a panel of immunohistochemical stains, including Desmin, GFAP, NFP, HMB45, SMA, S100, CK and EMA. Ultrastructral analysis was done on tissue obtained from paraffin blocks in 2 cases. Male predominance (M:F = 5:1) was noted with an incidence of five percent of all cases of medulloblastoma (6 out of 120 cases) over a period of 6
Expert-reviewed information summary about the treatment of childhood medulloblastoma, nonmedulloblastoma embryonal tumors, and pineal tumors.
Expert-reviewed information summary about the treatment of childhood medulloblastoma, nonmedulloblastoma embryonal tumors, and pineal tumors.
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A 14-year-old girl came into the ER with a prolonged history of vomiting and headaches. I looked at her MRI and saw what appeared to be a medulloblastoma, the most common malignant brain tumor in children. Theres some urgency to dealing with t [...]
Medulloblastoma arises from mutations occurring in stem/progenitor cells located in restricted hindbrain territories. Here we report that the mouse postnatal ventricular zone lining the IV ventricle also harbors bona fide stem cells that, remarkably, share the same molecular profile with cerebellar white matter-derived neural stem cells (NSC). To identify novel molecular mediators involved in medulloblastomagenesis, we compared these distinct postnatal hindbrain-derived NSC populations, which are potentially tumor initiating, with murine compound Ptch/p53 mutant medulloblastoma cancer stem cells (CSC) that faithfully phenocopy the different variants of human medulloblastoma in vivo. Transcriptome analysis of both hindbrain NSCs and medulloblastoma CSCs resulted in the generation of well-defined gene signatures, each reminiscent of a specific human medulloblastoma molecular subclass. Most interestingly, medulloblastoma CSCs upregulated developmentally related genes, such as Ebfs, that were shown ...
In the journal Cancer Research, UNC Lineberger researchers led by member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify a suitable therapeutic target within the sugar metabolism pathway, and provide clues to a scientific mystery surrounding the confounding way that some cancer cells get energy from sugar. ...
1. Although surgery remains the major treatment for medulloblastoma, there is still controversy regarding the impact of resection on the prognosis of patients with medulloblastoma. Furthermore, in cases of adherent medulloblastoma to the brainstem, complete resection is extremely difficult. In addition, metastasis via the cerebrospinal fluid is common; thus, medulloblastoma patients often have a poor prognosis and a high mortality rate 2.. Clinically, the prognosis of patients with medulloblastoma is often determined according to the pathological type, which also provides a reference for the application of adjunctive therapies, such as radiotherapy and chemotherapy 3,4. Currently, the World Health Organization (WHO) classification system for medulloblastoma is based on histomorphology. However, patients with the same pathological type of medulloblastoma still have distinct genetic backgrounds. Therefore, the prognosis of patients with medulloblastoma may vary even within the same WHO ...
TY - JOUR. T1 - A fibrotic nodule arising from the cerebellopontine angle. AU - Amano, Toshiyuki. AU - Suzuki, Satoshi. AU - Mizoguchi, Masahiro. AU - Yoshimoto, Koji. AU - Nakamizo, Akira. AU - Murata, Hideki. AU - Iwaki, Toru. AU - Sasaki, Tomio. PY - 2013/4/1. Y1 - 2013/4/1. N2 - The authors present an extremely rare case of a fibrotic nodule arising from the cerebellopontine (CP) angle. A 57-year-old male had suffered from hearing disturbance and tinnitus for several years. Computed tomography revealed a high-density mass in the left CP angle with little enhancement after intravenous administration of contrast media. Magnetic resonance imaging (MRI) showed a very hypointense mass on T2-weighted imaging. T1-weighted MRI with gadolinium revealed very faint, delayed enhancement of the tumor. The patient underwent surgical resection of the tumor. Histopathologically the lesion comprised entirely fibrotic tissue consisting of thick collagenous fibers and sclerosing blood vessels with a few ...
TY - JOUR. T1 - Epigenetic regulation in medulloblastoma. AU - Yi, Jiaqing. AU - Wu, Jiang. N1 - Funding Information: The work in the Wu lab is supported by grants from NINDS (R01NS096068, R21NS104596), the American Cancer Society, and the Welch Foundation (to J. Wu).. PY - 2018/3. Y1 - 2018/3. N2 - Medulloblastoma is the most common malignant childhood brain tumor. The heterogeneous tumors are classified into four subgroups based on transcription profiles. Recent developments in genome-wide sequencing techniques have rapidly advanced the understanding of these tumors. The high percentages of somatic alterations of genes encoding chromatin regulators in all subgroups suggest that epigenetic deregulation is a major driver of medulloblastoma. In this report, we review the current understanding of epigenetic regulation in medulloblastoma with a focus on the functional studies of chromatin regulators in the initiation and progression of specific subgroups of medulloblastoma. We also discuss the ...
... brain stem neoplasms MeSH C04.588.614.250.195.411.211 - cerebellar neoplasms MeSH C04.588.614.250.195.648 - neurocytoma MeSH ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
... brain stem neoplasms MeSH C10.228.140.211.500.200 - cerebellar neoplasms MeSH C10.228.140.211.692 - neurocytoma MeSH C10.228. ... brain stem neoplasms MeSH C10.551.240.250.400.300 - cerebellar neoplasms MeSH C10.551.240.250.550 - neurocytoma MeSH C10.551. ... hypothalamic neoplasms MeSH C10.228.140.211.885.500.600 - pituitary neoplasms MeSH C10.228.140.252 - cerebellar diseases MeSH ... spinal cord neoplasms MeSH C10.551.240.750.200 - epidural neoplasms MeSH C10.551.360.500 - optic nerve neoplasms MeSH C10.551. ...
... familial Pancreatic diseases Pancreatic islet cell neoplasm Pancreatic islet cell tumors Pancreatic lipomatosis duodenal ... dystrophy Proximal myotonic myopathy Proximal spinal muscular atrophy Proximal tubulopathy diabetes mellitus cerebellar ataxia ... et varioliformis acuta Pityriasis rubra pilaris Piussan-Lenaerts-Mathieu syndrome Placenta disorder Placenta neoplasm Placental ... virus type 3 antenatal infection Paramyotonia congenita of von Eulenburg Paramyotonia congenita Paraneoplastic cerebellar ...
Calbindin is expressed by cerebellar Purkinje cells and granule cells of the hippocampus. The reorganization and migration of ... In pathological conditions was also reported that glial neoplasms and reactive glial cells expressed this marker. Calretinin is ...
... and neoplasms. In neonates, hypoxic injury to the cerebellum is fairly common, resulting in neuronal loss and gliosis. Symptoms ... The cerebellar vermis (from Latin vermis, "worm") is located in the medial, cortico-nuclear zone of the cerebellum, which is in ... The cerebellar vermis evolved in conjunction with the hemispheres; this is seen in lampreys and higher vertebrates. In ... Coffman, K. a, Dum, R.P. & Strick, P.L. (2011). "Cerebellar vermis is a target of projections from the motor areas in the ...
... dominant pure Cerebellar degeneration, subacute Cerebellar degeneration Cerebellar hypoplasia endosteal sclerosis Cerebellar ... Carrington syndrome Cartilage-hair hypoplasia Cartilage hair hypoplasia like syndrome Cartilaginous neoplasms Cartwright-Nelson ... Cerebellar agenesis Cerebellar ataxia areflexia pes cavus optic atrophy Cerebellar ataxia ectodermal dysplasia Cerebellar ... hypoplasia tapetoretinal degeneration Cerebellar hypoplasia Cerebellar parenchymal degeneration Cerebelloolivary atrophy ...
Temtamy-Shalash syndrome TEN Ter Haar-Hamel-Hendricks syndrome Ter Haar syndrome Teratocarcinosarcoma Teratoma Testes neoplasm ... palmoplantar keratoderma Thrombasthenia Thrombocytopathy asplenia miosis Thrombocytopathy Thrombocytopenia cerebellar ... mental retardation Thymic carcinoma Thymic epithelial tumor Thymic renal anal lung dysplasia Thymoma Thymus neoplasm ... syndrome Tolosa-Hunt syndrome Toluene antenatal infection Tomaculous neuropathy Tome-Brune-Fardeau syndrome Tongue neoplasm ...
Lambert-Eaton paraneoplastic cerebellar degeneration) Lambert-Eaton syndrome Lamellar ichthyosis Lamellar recessive ichthyosis ... isolated Lissencephaly Listeria infection Listeriosis Livedoid dermatitis Liver cirrhosis Liver neoplasms Lobar atrophy of ... pulmonary Lymphangiomyomatosis Lymphatic filariasis Lymphatic neoplasm Lymphedema distichiasis Lymphedema hereditary type 1 ... syndrome Lung agenesis heart defect thumb anomalies Lung cancer Lung herniation congenital defect of sternem Lung neoplasm ...
... and cerebellar hypoplasia. Additionally, its absence can cause a decrease in Ngn2 and Neurod1 (in progenitor cells, and an ... resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, ...
Dalia S, Shao H, Sagatys E, Cualing H, Sokol L (October 2014). "Dendritic cell and histiocytic neoplasms: biology, diagnosis, ... Nussinovitch M, Prais D, Volovitz B, Shapiro R, Amir J (September 2003). "Post-infectious acute cerebellar ataxia in children ... Tang VK, Vijhani P, Cherian SV, Ambelil M, Estrada-Y-Martin RM (2018). "Primary pulmonary lymphoproliferative neoplasms". Lung ... and acute cerebellar ataxia. About 95% of the world's population is infected with EBV. During the initial infection, the virus ...
... syndrome Braddock-Jones-Superneau syndrome Bradykinesia Brain cavernous angioma Brain neoplasms Brain stem neoplasms Branchial ... Brachydactyly long thumb type Brachydactyly mesomelia mental retardation heart defects Brachydactyly nystagmus cerebellar ... Birt-Hogg-Dubé syndrome Bixler-Christian-Gorlin syndrome Björnstad syndrome BK virus nephritis Black piedra Bladder neoplasm ... craniosynostosis proptosis hydrocephalus Bone marrow failure neurologic abnormalities Bone marrow failure Bone neoplasms Bone ...
The most common site for cerebellar lesions that lead to intention tremors has been reported to be the superior cerebellar ... Focal lesions such as neoplasms, tumors, hemorrhages, demyelination, or other damage may be causing dysfunction of the ... Depending on the location of cerebellar damage, these tremors can be either unilateral or bilateral. A variety of causes have ... "Cerebellar Tremor-Definition and Treatment." The Colorado Neurological Institute Review. Fall 2005. [2] National Institute of ...
... often mistaking astroblastoma with glial neoplasms, high-grade astrocytes, and embryonal neoplasms. However, the "bubbly" ... The mass began at the brainstem, extended along the inferior cerebellar peduncle to roof areas against the ventricles through ... Furthermore, the absence of chromosome function in 9q, 10, and X were not observed in other types of neoplasms, such as an ... Neoplasm Neuroepithelial cell Astrocytes Glial cells Brain cancer Astroblastoma at Curlie Unal, Ekrem, and Yavuz Koksal. " ...
Cerebellar medulloblastoma in an adult Cerebellar medulloblastoma in an adult Treatment begins with maximal surgical removal of ... Intracranial Neoplasms and Paraneoplastic Disorders". In Ropper AH, Samuels MA (eds.). Adams and Victor's Principles of ... Gurney JG, Smith MA, Bunin GR (1999). "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). In Ries LA, Smith ... medulloblastomas are thought to arise from cerebellar stem cells that have been prevented from dividing and differentiating ...
Where an underlying neoplasm is the cause, treatment of this condition is indicated in order to reduce progression of symptoms ... Sicca syndrome No indication from the history or physical examination of cerebellar, striatal, pyramidal, and extrapyramidal ...
The presence of symmetrical cerebellar and pontine signal changes on T2-weighted images seem to be typical of ECD, however, ... "Erdheim-Chester Disease Declared a Histiocytic Neoplasm" (PDF). Retrieved 2018-07-18. "Erdheim-Chester disease at the United ... It was declared a histiocytic neoplasm by the World Health Organization in 2016. Onset typically is in middle age. The disease ...
... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... cerebellar ataxia MeSH C23.888.592.350.090.600 - gait ataxia MeSH C23.888.592.350.110 - athetosis MeSH C23.888.592.350.200 - ... neoplasm metastasis MeSH C23.550.727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ...
Severe lupus cerebritis symptoms include psychosis, dementia, peripheral neuropathy, cerebellar ataxia (failure of muscular ... and cannot reliably be distinguished from neoplasms. Cerebritis usually occurs as a result of an underlying condition, which ...
List of cutaneous neoplasms associated with systemic syndromes Mester J, Eng C (January 2015). "Cowden syndrome: recognizing ... Lhermitte-Duclos disease is a benign cerebellar tumor that typically does not manifest until adulthood in patients with Cowden ...
Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ... Myxosarcoma Astrocytoma Brainstem glioma Pilocytic astrocytoma Ependymoma Primitive neuroectodermal tumor Cerebellar ...
The neoplasms currently referred to as meningiomas were referred to with a wide range of names in older medical literature, ... Mutations in NF2 are commonly expressed in meningiomas located in the cerebral and cerebellar hemispheres. Meningiomas arise ... Even if, by general rule, neoplasms of the nervous system (brain tumors) cannot metastasize into the body because of the blood- ...
... congenital Stuccokeratosis Sturge-Weber syndrome Stuve-Wiedemann dysplasia Stye Subacute cerebellar degeneration Subacute ... muscular atrophy Spinal atrophy ophthalmoplegia pyramidal syndrome Spinal cord disorder Spinal cord injury Spinal cord neoplasm ... corneal dystrophy Spinocerebellar degenerescence book type Spirochetes disease Spirurida infections Spleen neoplasm Splenic ...
3.4 Other neoplasms related to the meninges 3.4.1 Haemangioblastoma (ICD-O 9161/1, WHO grade I) 4.1 Malignant Lymphomas (ICD-O ... 1.7.9 Cerebellar liponeurocytoma (ICD-O 9506/1, WHO grade II) 1.7.10 Papillary glioneuronal tumour (ICD-O 9509/1, WHO grade I) ...
Abdominal neoplasms Aberrant subclavian artery Ablepharon macrostomia syndrome Abnormal systemic venous return Abruzzo-Erickson ... Anguillulosis Aniridia Aniridia absent patella Aniridia ataxia renal agenesis psychomotor retardation Aniridia cerebellar ... X-linked Adrenal incidentaloma Adrenal insufficiency Adrenal macropolyadenomatosis Adrenal medulla neoplasm Adrenocortical ... Abdominal cystic lymphangioma Abdominal defects Abdominal musculature absent microphthalmia joint laxity Abdominal neoplasm / ...
Nussinovitch M, Prais D, Volovitz B, Shapiro R, Amir J (September 2003). "Post-infectious acute cerebellar ataxia in children ... An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation". The ... cerebellar ataxia, particularly childhood cases of this disorder, and two autoimmune diseases, multiple sclerosis and systemic ...
Mauro A, Orsi L, Mortara P, Costa P, Schiffer D (1991). "Cerebellar syndrome in adult celiac disease with vitamin E deficiency ... also EATL is the most common neoplasm.[7] ...
Mauro A, Orsi L, Mortara P, Costa P, Schiffer D (1991). "Cerebellar syndrome in adult celiac disease with vitamin E deficiency ... also EATL is the most common neoplasm. Squamous carcinoma of the esophagus is more prevalent in coeliac disease. The increased ...
2005). "Assessment of JC polyoma virus in colon neoplasms". Dis. Colon. Rectum. 48 (1): 86-91. doi:10.1007/s10350-004-0737-2. ... ultimately causing severe cerebellar atrophy.[14] This syndrome, called JCV granule cell layer neuronopathy (JCV GCN), is ...
They look like intracranial neoplasms, and sometimes they get biopsied as suspected tumors. Proton MR spectroscopy can help in ... cerebellar cortex, deep grey matter nuclei and the spinal cord". J Neurol Neurosurg Psychiatry. 80 (2): 182-7. doi:10.1136/jnnp ...
Dysplastic cerebellar gangliocytoma histology. Lhermitte-Duclos disease (LDD) (English: /ˌlɛərˈmiːtˌduːˈkloʊ/), also called ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... In Lhermitte-Duclos disease, the cerebellar cortex loses its normal architecture, and forms a hamartoma in the cerebellar ... The tumors are usually found on the left cerebellar hemisphere, and consist of abnormal hypertrophic ganglion cells that are ...
Brachydactyly nystagmus cerebellar ataxia. *Brachydactyly preaxial hallux varus. *Brachydactyly scoliosis carpal fusion ... Brain neoplasms. *Brain stem neoplasms. *Branchial arch defects. *Branchial arch syndrome X linked ...
I66.3) Occlusion and stenosis of cerebellar arteries. *(I66.4) Occlusion and stenosis of multiple and bilateral cerebral ... Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ...
In Lhermitte-Duclos disease, the cerebellar cortex loses its normal architecture, and forms a hamartoma in the cerebellar ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... The tumors are usually found on the left cerebellar hemisphere, and consist of abnormal hypertrophic ganglion cells that are ... MICROSCOPY(lhermitte-duclos disease) 1,Enlarged circumscribed cerebellar folia 2,internal granular layer is focally indistinct ...
So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple ... "Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage". European Journal of Pharmacology. 537 (1- ...
G11.1) Early-onset cerebellar ataxia *Early-onset cerebellar ataxia with essential tremor ... Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ...
Overall survival prognosis is about 30%. Deaths due to malignant neoplasms of the bones and joints account for an unknown ... "Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog". Journal of Veterinary ... Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and ...
Cerebellar damage produces disorders in fine movement, equilibrium, posture, and motor learning in humans. Cerebrum - is a ... Papillary - In oncology, papillary refers to neoplasms with projections ("papillae", from Latin, 'nipple') that have ... Fine EJ, Ionita CC, Lohr L (December 2002). "The history of the development of the cerebellar examination". Seminars in ... "Evaluating the affective component of the cerebellar cognitive affective syndrome". Journal of Neuropsychiatry and Clinical ...
Surgical treatment of cerebral edema in the context of cerebellar or cerebral infarction is typically done by removing part of ... cerebral neoplasm. Clinical researches have recommended ICP and cerebral perfusion pressure (CPP) monitoring in any persons ... "Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare ...
NOS M8000/6 Neoplasm, metastatic Neoplasm, metastatic Tumor, metastatic Tumor, secondary Tumor embolus M8000/9 Neoplasm, ... Supratentorial PNET M9474/3 large cell medulloblastoma M9480/3 Cerebellar sarcoma, NOS M9490/0 Ganglioneuroma M9490/3 ... benign M8000/1 Neoplasm, uncertain whether benign or malignant Neoplasm, NOS Tumor, NOS Unclassified tumor, uncertain whether ... M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67._) Papillary urothelial neoplasm of low malignant ...
... colorectal neoplasms, hereditary nonpolyposis MeSH C16.320.700.305 - dysplastic nevus syndrome MeSH C16.320.700.330 - exostoses ... myoclonic cerebellar dyssynergia MeSH C16.320.400.780.750 - olivopontocerebellar atrophies MeSH C16.320.400.780.875 - ...
Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar Neoplasms. On-line free medical diagnosis assistant. ... Cerebellar Neoplasms (Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar Neoplasms). Primary or metastatic ... "Cerebellar Neoplasms"Drugs, active principles and "Cerebellar Neoplasms"Medicinal plantsQuestions and answers from other users ... Common primary cerebellar tumors include fibrillary astrocytoma and cerebellar hemangioblastoma. The cerebellum is a relatively ...
Cancer Cerebellar, Cerebellar Cancer, Cerebellar Cancers, CEREBELLAR NEOPLASM, CEREBELLAR NEOPLASM BENIGN, Cerebellar Neoplasm ... They are ordered first by their relevance to Cerebellar Neoplasms and then by their general relevance to pain. Please click on ... They are ordered first by their pain relevance and then by number of times they were reported in Cerebellar Neoplasms. Please ... The table below shows the top 200 pain related interactions that have been reported for Cerebellar Neoplasms. ...
Brain Neoplasms. Central Nervous System Neoplasms. Nervous System Neoplasms. Neoplasms by Site. Neoplasms. Brain Diseases. ... Cerebellar Mutism Syndrome Study. The safety and scientific validity of this study is the responsibility of the study sponsor ... The ultimate aim of the study is to reduce the incidence and improve the treatment of cerebellar mutism syndrome and lead to ... One of the most troublesome late effects after neurosurgery for such a tumour is the cerebellar mutism syndrome which is seen ...
Cerebellar Neoplasms. Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA ... Paraneoplastic Cerebellar Degeneration. Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations ... A Registered Cohort Study on Cerebellar Ataxia. Cerebellar ataxia is a form of ataxia originating in the cerebellum. Cerebellar ... The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and ...
Cerebellar Neoplasms. Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA ... Paraneoplastic Cerebellar Degeneration. Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations ... A Registered Cohort Study on Cerebellar Ataxia. Cerebellar ataxia is a form of ataxia originating in the cerebellum. Cerebellar ... The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and ...
Neoplasms of the posterior fossa. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck ...
Cerebellar Diseases. Brain Diseases. Central Nervous System Diseases. Brain Neoplasms. Central Nervous System Neoplasms. ... Infratentorial Neoplasms. Ataxia. Cerebellar Ataxia. Dyskinesias. Neurologic Manifestations. Nervous System Diseases. ... MedlinePlus Genetics related topics: VLDLR-associated cerebellar hypoplasia Autosomal recessive cerebellar ataxia type 1 ...
The MCPs are predominantly supplied by the anterior inferior cerebellar arteries (AICA), but also the superior cerebellar ... Steroid refractory giant cell arteritis with bilateral vertebral artery occlusion and middle cerebellar peduncle infarction. ... We describe a 72-year-old male who developed bilateral vertebral artery occlusion and middle cerebellar peduncle infarction ... This case report describes an unusual presentation of GCA with bilateral cerebellar peduncle infarcts refractory to empirical ...
Cerebellar Neoplasms / classification* * Cerebellar Neoplasms / genetics* * Cerebellar Neoplasms / pathology * Child * Class I ...
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cerebellar tumour † 1 0/44 (0.00%) 0/42 (0.00%) 1/169 (0.59 ...
Cerebellar Neoplasms / metabolism* * Drug Resistance * Guanine / analogs & derivatives* * Guanine / pharmacology * Humans * ...
neoplasms (C00-D49). *symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94) ... Early-onset cerebellar ataxia. 2016 2017 2018 2019 2020 Billable/Specific Code *G11.1 is a billable/specific ICD-10-CM code ... A condition marked by progressive cerebellar ataxia combined with myoclonus usually presenting in the third decade of life or ... cerebellar cortex, and basal ganglia. (from Joynt, Clinical Neurology, 1991, ch37, pp60-1) ...
Hepatic involvement by T-cell neoplasms: a clinicopathologic study of 40 cases.. October 5, 2020 ... Dysplastic Cerebellar Gangliocytoma(Lhermitte-Duclos Disease)].. March 29, 2021. Hematological and Biochemical Profile of ...
8. Brain Stem Neoplasms. 9. Cerebellar abscess. 10. Cerebellar ataxia, X-linked. More causes » , Show All 66 Causes , Show ... 1. Cerebellar abscess. Show causes with descriptions ». , Start Again ». Note: Do not use for diagnosis; see limitations of ...
Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms. Pediatr Neurosurg 2011;47:51- ... of pediatric cerebellar tumors.1 Therefore, when a new pediatric cerebellar tumor is encountered, it is very likely that the ... The reviewers were given relevant literature1,2,4⇓⇓-7 on the imaging of pediatric cerebellar tumors and utility of diffusion MR ... Conventional MR imaging findings of common cerebellar tumors are well known.5,9⇓-11 PAs are characteristically well delineated ...
Although cerebellar enlargement occurs in ptch1 heterozygous-deficient mice, its impact on human brain development remains ... Basaloid follicular hamartomas (BFHs) constitute rare neoplasms that can be detected in sporadic and familial settings as in ... 151.3 [8.7] mm, P = 0.0007) of the cerebrum, cross-sectional area of the cerebellar vermis (18.7 [2.6] vs. 11.8 [1.7] cm ... 11.6 [2.3] years old). The diameters of the cerebrum, corpus callosum, and brain stem and the cerebellar volume were compared ...
What is Supratentorial neoplasms? Meaning of Supratentorial neoplasms medical term. What does Supratentorial neoplasms mean? ... Looking for online definition of Supratentorial neoplasms in the Medical Dictionary? Supratentorial neoplasms explanation free ... redirected from Supratentorial neoplasms) tentorium. [ten-tor´e-um] (L.) an anatomical part resembling a tent or covering. adj ... Supratentorial neoplasms , definition of Supratentorial neoplasms by Medical dictionary https://medical-dictionary. ...
Results: An underlying malignancy could be detected in 8 / 30 Patients (27%). F-18-FDG-PET found 7 out of 8 malignant neoplasms ... Diagnoses were cerebellar degeneration, erythrodermia, dermatomyositis, polneuropathia and others. PET-Scans were evaluated for ... There were also one benign neoplasm and two inflammatory diseases. The remaining patients did not demonstrate a malignancy ...
Neoplasm: Cerebellar tumor; Hydrocephalus, obstructive. * Head MR. Initial Scan - 23 series * T1 - Sagittal ...
Neoplasm: Cerebellar tumor; Hydrocephalus, obstructive. MR. 8360. 40. F. Dissection, vertebral artery (L); Systemic lupus ... Neoplasm: Glioma, thalamus (L). CT. 17327. 50. M. Neoplasm: Glial tumor, leptomeningeal involvement, temporal lobe (R) and T11 ... Infarct, posterior inferior cerebellar artery, acute (L); Infarct, middle cerebral artery, old (L); Infarct, anterior cerebral ...
most COMMON type of childhood brain neoplasm. - Posterior fossa= cerebellar. - GFAP positive ... Pituitary adenomas are neoplasm of the Adenohypophysis. - Approximately 15% of intracranial neoplasms.. - Predominantly affect ... Most often cerebellar. - Associted with von Hippel Lindau syndrome when found with retinal angiomas. - Can produce EPO--, ... Relatively common neoplasms accounting for approximately 15% of all primary intracranial tumors. Occur in middle life, usually ...
Here we assessed whether cerebellar damage also disturbs explicit semantic processing of action pictures and its integration ... We evaluated a cognitively preserved 33-year-old man with severe dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease ... We evaluated a cognitively preserved 33-year-old man with severe dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease ... suggesting that motor-semantic integration dynamics may be compromised following cerebellar damage. Notably, a Bayesian Test ...
30 Brain L, Wilkinson M. Subacute cerebellar degeneration associated with neoplasms. Brain 1965; 88: 465-78. ... Paraneoplastic cerebellar degeneration Paraneoplastic cerebellar degeneration (PCD) was the first paraneoplasia to be described ... The autoantigens are organ and cell-specific, and in some cases surgical removal of the neoplasm has resulted in amelioration ... Subacute cortical cerebellar degeneration and its relation to carcinoma. J Neurol Neurosurg Psychiatry 1951; 14: 59-75. ...
Brain Cancer (Meningel Neoplasm) * Brain Cancer (Meningioma) * Cerebellar Cancer * Cerebellar Diseases * Cranial Nerve Cancer ...
Cerebellar Neoplasms. 1. 1990. 560. 0.020. Why? Astrocytoma. 1. 1990. 760. 0.020. Why? ...
... we used DTI to investigate cerebellar peduncle lesions of patients who showed severe ataxia following DAI. Six patients with ... 21435189 - Prevalence of overt myeloproliferative neoplasms and jak2 v617f mutation in korean pati.... 9313999 - Motor and ... Using DTI-Studio software, three cerebellar peduncles (superior cerebellar peduncle, SCP; middle cerebellar peduncle, MCP; ... inferior cerebellar peduncle, ICP) were evaluated. In each cerebellar peduncle, fractional anisotropy was estimated using the ...
Cerebellar Neoplasms / mortality, pathology, surgery*. Cerebrospinal Fluid Shunts. Chemotherapy, Adjuvant. Combined Modality ... Neoplasm Recurrence, Local / mortality, pathology, surgery. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. ...
MalaCards based summary : Cerebellum Cancer, also known as cerebellar neoplasms, is related to cerebellar medulloblastoma and ... The transitory superficial granular layer of the cerebellar cortex; its relationship to certain cerebellar neoplasms. ( ... Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis. ( ... Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms. ( 21921669 ) ...
Pediatric patients with cerebellar neoplasms found to have an RT2SI of less than or equal to 0.71 are recommended for neuraxis ... Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis Clinical ... The authors first reviewed the literature to gain an appreciation of the risk of LD of pediatric cerebellar neoplasms based on ... Of the 31 neoplasms retrospectively designated as hypointense T2-weighted lesions (RT2SI ≤ 0.71), 30 (97%) were Grade II or ...
untreated childhood cerebellar astrocytoma. *childhood high-grade cerebral astrocytoma. *childhood spinal cord neoplasm ...
  • Cerebellar ataxia is a form of ataxia originating in the cerebellum. (bioportfolio.com)
  • Cerebellar ataxia can occur as a result of many diseases and may present with symptoms of an inability to coordinate ba. (bioportfolio.com)
  • A condition marked by progressive cerebellar ataxia combined with myoclonus usually presenting in the third decade of life or later. (icd10data.com)
  • Cerebellar peduncle injury in patients with ataxia following diffuse axonal injury. (biomedsearch.com)
  • In the current study, we used DTI to investigate cerebellar peduncle lesions of patients who showed severe ataxia following DAI. (biomedsearch.com)
  • Evaluation of the cerebellar peduncles using DTI can be helpful in patients with ataxia following DAI. (biomedsearch.com)
  • Cerebellum Cancer, also known as cerebellar neoplasms , is related to cerebellar medulloblastoma and medulloblastoma , and has symptoms including cerebellar ataxia An important gene associated with Cerebellum Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers . (malacards.org)
  • Type I autosomal dominant cerebellar ataxia (ADCA) is a type of spinocerebellar ataxia (SCA) characterized by ataxia with other neurological signs, including oculomotor disturbances, cognitive deficits, pyramidal and extrapyramidal dysfunction, bulbar, spinal and peripheral nervous system involvement. (biomedcentral.com)
  • Cerebellar ataxia can affect virtually any body part causing movement abnormalities. (biomedcentral.com)
  • Gait, truncal, and limb ataxia are often the most obvious cerebellar findings though nystagmus, saccadic abnormalities, and dysarthria are usually associated. (biomedcentral.com)
  • Diseases associated with CDR2L include Cerebellar Degeneration and Spinocerebellar Ataxia, Autosomal Recessive 13 . (genecards.org)
  • Cowden Syndrome 1, also known as lhermitte-duclos disease , is related to pten hamartoma tumor syndrome and cowden disease , and has symptoms including seizures , action tremor and cerebellar ataxia . (malacards.org)
  • We describe a case of cerebellar ataxia associated with anti-Hu antibodies and benign ganglioneuroma. (elsevier.com)
  • While ataxic dysarthria was the most common speech diagnosis, a spastic component was recognized frequently enough to suggest that the subacute (days to weeks) emergence and progression of an ataxic or mixed ataxic-spastic dysarthria in the setting of a more diffuse cerebellar ataxia should raise suspicions about PCD and justify further investigation of a possible immune-related etiology. (elsevier.com)
  • Segment 1 showed moderate cerebellar ataxia with ample sustentation base and poor coordination on assisted ambulation. (bmj.com)
  • Cerebellar gait ataxia with an ample sustentation base was present. (bmj.com)
  • Other immune-mediated cerebellar ataxias including gluten ataxia, paraneoplastic cerebellar degeneration, Hashimoto's encephalopathy and other differentials were also considered ( table 1 ). (bmj.com)
  • GAD-Abs associated cerebellar ataxia with nystagmus was diagnosed based on the neuroclinical manifestations, elevated serum GAD-Abs, MRI findings, exclusion of other diseases with further support from the patient's clinical and biochemical response to immunomodulation. (bmj.com)
  • The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS). (clinicaltrials.gov)
  • Cerebral meningioma is the most frequently reported primary brain tumor of cats and accounts for almost 10% of all nonhematopoietic neoplasms. (vin.com)
  • Intra-operatively, the surgeon noted expanded cerebellar cortex with associated leptomeningeal coating or opacification suspicious for tumor involvement. (upmc.edu)
  • A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). (curehunter.com)
  • The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. (curehunter.com)
  • If no known family history exists, at least 2 cerebellar hemangioblastomas or 1 hemangioblastoma plus 1 visceral tumor are necessary to justify the diagnosis of VHL. (medscape.com)
  • Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm? (thefreedictionary.com)
  • As a term, cerebellar liponeurocytoma is now largely accepted and is supported by genetic analyses that indicate that this lesion is not a variant of medulloblastoma [7,10]. (termedia.pl)
  • Interestingly, a rare case of cerebellar medulloblastoma was correctly identified in MRI scans. (vetcontact.com)
  • Disease and disorder research has been conducted in relation to the Cerebellum Development Pathway and Nervousness, Neoplasms, Medulloblastoma, Cerebellar Neoplasms, Malignant Neoplasms. (novusbio.com)
  • Pathologically, the dentate nucleus and brachium conjunctivum of the cerebellum are atrophic, with variable involvement of the spinal cord, cerebellar cortex, and basal ganglia. (icd10data.com)
  • We evaluated a cognitively preserved 33-year-old man with severe dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease), encompassing most of the right cerebellum and the posterior part of the left cerebellum. (frontiersin.org)
  • The cerebellar vermis (from Latin vermis, "worm") is located in the medial, cortico-nuclear zone of the cerebellum, which is in the posterior fossa of the cranium. (wikipedia.org)
  • The cerebellum develops in a rostro-caudal manner, with rostral regions in the midline giving rise to the vermis, and caudal regions developing into the cerebellar hemispheres. (wikipedia.org)
  • Postnatally, proliferation and organization of the cellular components of the cerebellum continues, with completion of the foliation pattern by 7 months of life and final migration, proliferation, and arborization of cerebellar neurons by 20 months. (wikipedia.org)
  • Anomalies of the cerebellar vermis are diagnosed in this manner and include phenotypes consistent with Dandy-Walker malformation, rhombencephalosynapsis, displaying no vermis with fusion of the cerebellar hemispheres, pontocerebellar hypoplasia, or stunted growth of the cerebellum, and neoplasms. (wikipedia.org)
  • Paraneoplastic cerebellar degeneration (PCD) was the first paraneoplasia to be described and occurs in a wide range of different types of neoplasia such as lymphomas, carcinomas of the ovaries, uterus, breast, in addition to the most frequently culpable small cell carcinoma. (redorbit.com)
  • Coding guidelines are similar for cerebellar degeneration, another paraneoplastic neurologic condition. (hcpro.com)
  • Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disease that can be associated with cancer of the breast, lung, and ovary. (elsevier.com)
  • Paraneoplastic cerebellar degeneration (pcd) often harbor gynaecological neoplasms. (reprosource.com)
  • This report represents the first case of an anti-Ri positive paraneoplastic brainstem encephalitis in a patient with exceptionally long course of a metastasized neuroendocrine rectum neoplasm. (biomedcentral.com)
  • Although utility of diffusion MR imaging in the preoperative diagnosis of common pediatric cerebellar tumors is generally recognized, its added value has not been systematically studied previously. (ajnr.org)
  • The purpose of this study was to evaluate the impact of diffusion MR imaging on the accuracy of preoperative diagnosis of common pediatric cerebellar tumors among reviewers with different experience levels. (ajnr.org)
  • Primary brain tumors arise from CNS tissue and account for roughly half of all cases of intracranial neoplasms. (medscape.com)
  • Presenting complaints of patients with an intracranial neoplasm tend to be similar for primary brain tumors and intracranial metastases. (medscape.com)
  • Medulloblastomas are primarily childhood tumors, where they account for one third of all posterior fossa neoplasms. (uab.edu)
  • Pituitary gland neoplasms and tumors arising from cranial nerves are considered secondary brain tumors. (vin.com)
  • Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. (ki.se)
  • Hemangioblastomas are considered to be benign neoplasms and represent 1-2% of all primary central tumors. (medscape.com)
  • Cerebellar degeneration associated with a remote neoplasm. (bioportfolio.com)
  • CDR2L (Cerebellar Degeneration Related Protein 2 Like) is a Protein Coding gene. (genecards.org)
  • Here, we show electron microscopic evidence of degeneration of several different types of neurons in the cerebellar cortex of 2-month-old Atm knockout mice, which is accompanied by glial activation, deterioration of neuropil structure, and both pre- and postsynaptic degeneration. (pnas.org)
  • The clinical spectrum ranges from pure cerebellar signs to constellations including spinal cord and peripheral nerve disease, cognitive impairment, cerebellar or supranuclear ophthalmologic signs, psychiatric problems, and seizures. (biomedcentral.com)
  • In over 40 cases of A-T, necropsy has shown that there is atrophy of all cerebellar cortical layers with extensive Purkinje and granule cell loss, dentate and olivary nuclei atrophy, neuronal loss in the substantia nigra and oculomotor nuclei, spinal cord atrophy, and degenerative changes in spinal motor neurons and dorsal root and sympathetic motor neurons ( 9 - 11 ). (pnas.org)
  • The vermis is intimately associated with all regions of the cerebellar cortex, which can be divided into three functional parts, each having distinct connections with the brain and spinal cord. (wikipedia.org)
  • Lhermitte-Duclos disease: A rare disease characterized by the occurrence of a slowly enlarging mass within the cerebellar cortex corresponding histologically to a cerebellar hamartoma. (malacards.org)
  • MICROSCOPIC PATHOLOGY Histologically, there was a moderately to highly cellular neoplasm that extensively invaded the cerebellar cortex (Fig. 5 ) and, to a lesser extent, the underlying white matter, often entrapping both internal granular layer and Purkinje cell neurons, the latter involved in occasional vague perineuronal satellitosis. (upmc.edu)
  • It sends fibers to deep cerebellar nuclei that, in turn, project to both the cerebral cortex and the brain stem, thus providing modulation of descending motor systems. (wikipedia.org)
  • 1 Growth is slow and there is no reported malignant potential with clinical presentation typically entailing signs of increased intracranial pressure, obstructive hydrocephalus, and cerebellar dysfunction. (appliedradiology.com)
  • Neoplasms of the posterior fossa. (medlineplus.gov)
  • Diagnosis of the DWM is based on a series of characteristic neuroimaging findings, which include complete or partial agenesis of the cerebellar vermis, cystic dilatation of the fourth ventricle, and enlarged posterior fossa. (lww.com)
  • Computed tomography brain scans (3 subjects), magnetic resonance imaging brain study (1 subject), cerebral arteriography (1 subject), cerebellar biopsy (1 subject), and necropsy (2 subjects). (aappublications.org)
  • To our knowledge, this is the first report of an MTB causing both severe cerebral and cerebellar compression and the second detailed report of an MTB of the occipital bone. (openarchives.gr)
  • An initial magnetic resonance (MR) scan of the brain demonstrated several areas of restricted diffusion in both cerebellar hemispheres (Figure 1a), consistent with multiple infarcts. (rcpe.ac.uk)
  • Tumours are predominantly located in cerebellar hemispheres, followed by a more central location in the vermis [10]. (termedia.pl)
  • This region comprises the vermis and intermediate parts of the cerebellar hemispheres. (wikipedia.org)
  • It is a rare cerebellar neoplasm of adults with consistent neuronal, variable astrocytic and focal lipomatous differentiation, and with low proliferative potential. (termedia.pl)
  • Neuronal neoplasms are rare in domestic animals ( KOESTNER & HIGGINS, 2002 ). (scielo.br)
  • During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. (abcam.com)
  • Neuronal and astrocytic differentiation in human neuroepithelial neoplasms. (semanticscholar.org)
  • Medulloblastomas most commonly occur in the cerebellar vermis. (uab.edu)
  • Imaging studies depict the typical location in the cerebellar vermis, with filling and enlargement of the fourth ventricle. (uab.edu)
  • The radiologic finding of erosion of the skull base by this mass lesion may have contributed to its interpretation as a destructive neoplasm, with the differential diagnosis including chondrosarcoma, metastatic lesion, osteosarcoma, and meningioma. (thefreelibrary.com)
  • Kinds of angioblastomas are angioblastic meningioma and cerebellar angioblastoma . (thefreedictionary.com)
  • 1,2 The MR imaging appearance is considered diagnostic and can obviate biopsy, consisting of a tigroid, striated appearance of the nonenhancing cerebellar mass with superficial bands of alternating T2 hyper- and isointensity to grey matter, iso- and hypointense on T1-weighted imaging, with sporadic calcification reported and minimal loco-regional mass effect. (appliedradiology.com)
  • The hereditary cerebellar ataxias include diverse neurodegenerative disorders. (bioportfolio.com)
  • Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. (bioportfolio.com)
  • Autosomal Dominant Cerebellar Ataxias, Spinocerebellar ataxias. (biomedcentral.com)
  • The definition of spinal cerebellar ataxias (SCAs) despite significant progress in their understanding is still imprecise. (biomedcentral.com)
  • They can be divided by the mode of inheritance to autosomal dominant, autosomal recessive, or sporadic conditions, Harding proposed a classification of autosomal dominant cerebellar ataxias (ADCA) into three categories, Type I, Type II and Type III. (biomedcentral.com)
  • However, the histology in this case ruled out a diagnosis of neoplasm. (thefreelibrary.com)
  • In all 10 animals that finally died of the disease or were killed, the histopathological diagnosis that followed necropsy was taken as a golden standard in the CT or MRI prediction of the histological type of brain neoplasms. (vetcontact.com)
  • In patients with a positive family history, a single cerebellar hemangioblastoma is sufficient to make the diagnosis. (medscape.com)
  • We describe a 72-year-old male who developed bilateral vertebral artery occlusion and middle cerebellar peduncle infarction secondary to giant cell arteritis in spite of high-dose steroids. (rcpe.ac.uk)
  • c) Diffusion-weighted images with corresponding apparent diffusion coefficient map from repeat MRI showing bilateral middle cerebellar peduncle infarcts. (rcpe.ac.uk)
  • Contrast-enhanced computed tomography revealed three intensely enhancing masses in the right cerebellar hemisphere. (medscape.com)
  • Noncontrast CT imaging of the head performed in the ER demonstrated a roughly 6 cm mass centered in the superior right cerebellar hemisphere with cortical involvement and mild mass effect upon the fourth ventricle. (appliedradiology.com)
  • Sections on more than 70 neoplasms and their variants include ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors. (zvab.com)
  • The clinical appearance of the retromeatal CPA meningiomas is dominated by cerebellar symptoms. (springer.com)
  • The expression of antigens by various neoplasms lead to antibody formation that may induce an intrathecal inflammatory process leading to distinct neurological symptoms [ 4 , 5 ]. (biomedcentral.com)
  • There are few cases describing concomitant neurological symptoms in patients with neuroendocrine neoplasms, however, mostly due to excessive hormone release and seldomly correlated to positive antibodies [ 6 ]. (biomedcentral.com)
  • Twenty of 36 total cerebellar peduncles revealed more than one lesion (SCP: 8, ICP: 7, MCP: 5). (biomedsearch.com)
  • Primary central nervous system lymphoma is rare, accounting for 2-6% of all primary brain neoplasms and 1-2% of all non-Hodgkin lymphomas, and it usually presents as a solitary lesion. (medscape.com)
  • This case report describes an unusual presentation of GCA with bilateral cerebellar peduncle infarcts refractory to empirical treatment. (rcpe.ac.uk)
  • To bridge this gap, here we report the first assessment of explicit action-semantic processing and motor-semantic integration in a rare patient with bilateral cerebellar damage due to a dysplastic gangliocytoma (Lhermitte-Duclos disease). (frontiersin.org)
  • Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition. (bioportfolio.com)
  • During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood. (bioportfolio.com)
  • Classical models of cerebellar learning posit that climbing fibers operate according to a supervised learning rule to instruct changes in motor output by signaling the occurrence of movement errors. (bioportfolio.com)
  • New disease entities include the chordoid glioma of the third ventricle and the cerebellar liponeurocytoma. (zvab.com)
  • There were also one benign neoplasm and two inflammatory diseases. (eurekalert.org)
  • We describe an unusual case of non-granulomatous Acanthamoeba cerebellitis in an immunocompetent adult male, with abrupt onset of neurological impairment, subtle hemorrhagic infarction at magnetic resonance imaging, and initial suspicion of cerebellar neoplasm. (springer.com)
  • Diffusion tensor mri and fiber tractography of cerebellar atrophy in phenytoin users. (cns.org)
  • Brain MRI showed progressive cerebellar atrophy. (elsevier.com)
  • pathology astrocytomas of childhoodare comparatively benign, and commonly cerebellar. (guiltypleasures.co.uk)
  • The terms benign and malignant must be used carefullywhen referringto a brain neoplasm. (vin.com)
  • They developed primary cerebellar infarctions within days after the exposure that could not be attributed to supratentorial herniation syndromes and only minimally involved brainstem structures. (aappublications.org)
  • A broad spectrum of nonneoplastic conditions can radiologically and clinically mimic an intracranial neoplasm. (thefreelibrary.com)
  • This presentation is prepared for undergraduate students about the various myeloproliferative neoplasms with updated information. (slideshare.net)
  • One of the most troublesome late effects after neurosurgery for such a tumour is the cerebellar mutism syndrome which is seen in up to 25% of the patients. (clinicaltrials.gov)
  • One benign neoplasm caused increased tracer uptake, another PET positive patient refused biopsy and showed no growth of a malignant tumour during clinical follow up of 28 months. (minervamedica.it)
  • Haematologic and metabolic status, hepatic and renal function tests, collagen vascular tests, tumour markers, retroviral and syphilitic serological tests and cerebellar antibody panel for neoplasm were normal. (bmj.com)
  • The autoantigens are organ and cell-specific, and in some cases surgical removal of the neoplasm has resulted in amelioration of immune-mediated paraneoplasia.2,14-18 Gammaglobulin treatment is reported to have beneficial results in some through processes that include anti-idiotype immunomodulation.19 Plasmapheresis and immuno- suppression may provide symptomatic relief in others,3,6,15,20 but no single immunomodulation is universally successful. (redorbit.com)
  • Early recognition of the cerebellar stroke syndrome may allow prompt neurosurgical intervention, reducing morbidity. (aappublications.org)
  • The relationship with Cowden syndrome is both clinically relevant and pertinent as well due to the heightened predisposition in these patients for a vicissitude of both benign and malignant neoplasms involving the breast, thyroid, dermis, gastrointestinal, genitourinary and central nervous systems, with annual surveillance and screening measures being highly warranted. (appliedradiology.com)
  • In one patient with von Hippel-Lindau syndrome and multiple cerebellar hemangioblastomas, a feeding artery aneurysm was found on a distal branch of the AICA. (elsevier.com)
  • This section in the ICD-9-CM Manual offers direction for coding anemia and dehydration associated with malignancies, neoplasm-related pain, encounters for chemotherapy and radiotherapy, and complications resulting from surgical procedures performed to treat malignancies. (hcpro.com)
  • The remainder of brain neoplasms are caused by metastatic lesions. (medscape.com)
  • gene in adult mice results in nearly identical cerebellar phenotypes to those of the knockout, indicating that disruption of ciliary signaling is a key driver of these phenotypes. (bioportfolio.com)
  • No physical finding or pattern of findings unmistakably identifies a patient with a CNS neoplasm. (medscape.com)
  • Histopathological findings of excised cerebellar mass revealed the presence of necrosis and inflammation with structure resembling amoebic trophozoites, but without granulomas. (springer.com)
  • Cerebellar liponeurocytomas have been included in the 2000 World Health Organization (WHO) classification of tumours of the central nervous system, under the heading of glioneuronal tumours. (termedia.pl)
  • The current 2007 WHO classification therefore assigns cerebellar liponeurocytoma to WHO grade II [10,11]. (termedia.pl)
  • 20) Schmiegelow K. Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries. (rigshospitalet.dk)