Cerebellar Neoplasms: Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)Medical History Taking: Acquiring information from a patient on past medical conditions and treatments.Glial Fibrillary Acidic Protein: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.DNA Nucleotidylexotransferase: A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Microglia: The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Diffusion Magnetic Resonance Imaging: A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.Anisotropy: A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Diffusion: The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Libraries, Digital: Libraries in which a major proportion of the resources are available in machine-readable format, rather than on paper or MICROFORM.MissouriNeurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Library Technical Services: Acquisition, organization, and preparation of library materials for use, including selection, weeding, cataloging, classification, and preservation.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Catalogs, LibraryTranslational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.Libraries, MedicalEncephalitis, St. Louis: A viral encephalitis caused by the St. Louis encephalitis virus (ENCEPHALITIS VIRUS, ST. LOUIS), a FLAVIVIRUS. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus CULEX. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an ASEPTIC MENINGITIS or ENCEPHALITIS. Clinical manifestations of the encephalitic presentation may include SEIZURES, lethargy, MYOCLONUS, focal neurologic signs, COMA, and DEATH. (From Adams et al., Principles of Neurology, 6th ed, p750)Encephalitis Virus, St. Louis: A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiologic agent of ST. LOUIS ENCEPHALITIS in the United States, the Caribbean, and Central and South America.Calbindin 1: A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.Calbindins: Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.S100 Calcium Binding Protein G: A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)Bronchography: Radiography of the bronchial tree after injection of a contrast medium.Recurrence: The return of a sign, symptom, or disease after a remission.France: A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.Patient Acceptance of Health Care: The seeking and acceptance by patients of health service.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Cell-Matrix Junctions: Specialized areas at the CELL MEMBRANE where a cell attaches to the EXTRACELLULAR MATRIX or other substratum.Protein Splicing: The excision of in-frame internal protein sequences (INTEINS) of a precursor protein, coupled with ligation of the flanking sequences (EXTEINS). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.Cell Line, Tumor: A cell line derived from cultured tumor cells.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Neuroectodermal Tumors, Primitive: A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)Cell Line: Established cell cultures that have the potential to propagate indefinitely.

Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. (1/828)

PURPOSE: From 1986 to 1992, "eight-drugs-in-one-day" (8-in-1) chemotherapy both before and after radiation therapy (XRT) (54 Gy tumor/36 Gy neuraxis) was compared with vincristine, lomustine (CCNU), and prednisone (VCP) after XRT in children with untreated, high-stage medulloblastoma (MB). PATIENTS AND METHODS: Two hundred three eligible patients with an institutional diagnosis of MB were stratified by local invasion and metastatic stage (Chang T/M) and randomized to therapy. Median time at risk from study entry was 7.0 years. RESULTS: Survival and progression-free survival (PFS) +/- SE at 7 years were 55%+/-5% and 54%+/-5%, respectively. VCP was superior to 8-in-1 chemotherapy, with 5-year PFS rates of 63%+/-5% versus 45%+/-5%, respectively (P = .006). Upon central neuropathology review, 188 patients were confirmed as having MB and were the subjects for analyses of prognostic factors. Children aged 1.5 to younger than 3 years had inferior 5-year estimates of PFS, compared with children 3 years old or older (P = .0014; 32%+/-10% v 58%+/-4%, respectively). For MB patients 3 years of age or older, the prognostic effect of tumor spread (MO v M1 v M2+) on PFS was powerful (P = .0006); 5-year PFS rates were 70%+/-5%, 57%+/-10%, and 40%+/-8%, respectively. PFS distributions at 5 years for patients with M0 tumors with less than 1.5 cm2 of residual tumor, versus > or = 1.5 cm2 of residual tumor by scan, were significantly different (P = .023; 78%+/-6% v 54%+/-11%, respectively). CONCLUSION: VCP plus XRT is a superior adjuvant combination compared with 8-in-1 chemotherapy plus XRT. For patients with M0 tumors, residual tumor bulk (not extent of resection) is a predictor for PFS. Patients with M0 tumors, > or = 3 years with < or = 1.5 cm2 residual tumor, had a 78%+/-6% 5-year PFS rate. Children younger than 3 years old who received a reduced XRT dosage had the lowest survival rate.  (+info)

Hemangioblastoma mimicking tentorial meningioma: preoperative embolization of the meningeal arterial blood supply--case report. (2/828)

A 72-year-old male presented with a primary hemangioblastoma of the posterior fossa with unusual dural attachment and meningeal arterial blood supply from the external carotid artery and marginal tentorial artery. Preoperative embolization facilitated complete resection of the tumor with no resultant neurological deficit. Hemangioblastoma must be included in the differential diagnosis of tumors with dural involvement. Preoperative embolization is very useful in such tumors.  (+info)

Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells. (3/828)

Chemotherapeutic agents and gamma-irradiation used in the treatment of brain tumors, the most common solid tumors of childhood, have been shown to act primarily by inducing apoptosis. Here, we report that activation of the CD95 pathway was involved in drug- and gamma-irradiation-induced apoptosis of medulloblastoma and glioblastoma cells. Upon treatment CD95 ligand (CD95-L) was induced that stimulated the CD95 pathway by crosslinking CD95 via an autocrine/paracrine loop. Blocking CD95-L/receptor interaction using F(ab')2 anti-CD95 antibody fragments strongly reduced apoptosis. Apoptosis depended on activation of caspases (interleukin 1beta-converting enzyme/Ced-3 like proteases) as it was almost completely abrograted by the broad range caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone. Apoptosis was mediated by cleavage of the receptor proximal caspase FLICE/MACH (caspase-8) and the downstream caspase CPP32 (caspase-3, Apopain) resulting in cleavage of the prototype caspase substrate PARP. Moreover, CD95 was upregulated in wild-type p53 cells thereby increasing responsiveness towards CD95 triggering. Since activation of the CD95 system upon treatment was also found in primary medulloblastoma cells ex vivo, these findings may have implications to define chemosensitivity and to develop novel therapeutic strategies in the management of malignant brain tumors.  (+info)

Cicatricial fibromatosis mimics metastatic medulloblastoma. (4/828)

Cicatricial fibromatoses usually occur in the anterior abdominal wall or in the extremities, but rarely in the scalp or the soft tissues of the neck. We report a case of desmoid fibromatosis that developed in a 15-year-old boy 8 months after surgery for cerebellar medulloblastoma.  (+info)

Unexpected stomach uptake of technetium-99m-MDP. (5/828)

Two pediatric cases are described in which the results of each patient's bone scan demonstrated abnormal stomach uptake. There have been a number of reports in the literature describing stomach uptake of bone agents, however, it is an uncommon finding.  (+info)

Clinical features and outcomes in patients with non-acoustic cerebellopontine angle tumours. (6/828)

OBJECTIVES: Non-acoustic tumours of the cerebellopontine angle differ from vestibular schwannomas in their prevalence, clinical features, operative management, and surgical outcome. These features were studied in patients presenting to the regional neuro-otological unit. METHODS: A retrospective analysis of clinical notes identified 42 patients with non-acoustic tumours of the cerebellopontine angle. Data were extracted regarding presenting clinical features, histopathological data after surgical resection, surgical morbidity and mortality, and clinical outcome (mean 32 months follow up). RESULTS: The study group comprised 25 meningiomas (60%), 12 epidermoid cysts/cholesteatomata (28%), and five other tumours. In patients with meningiomas, symptoms differed considerably from patients presenting with vestibular schwannomas. Cerebellar signs were present in 52% and hearing loss in only 68%. Twenty per cent of patients had hydrocephalus at the time of diagnosis. After surgical resection, normal facial nerve function was preserved in 75% of cases. In the epidermoid group, fifth, seventh, and eighth nerve deficits were present in 42%, 33%, and 66% respectively. There were no new postoperative facial palsies. There were two recurrences (17%) requiring reoperation. Overall, there were two perioperative deaths from pneumonia and meningitis. CONCLUSIONS: Patients with non-acoustic lesions of the cerebellopontine angle often present with different symptoms and signs from those found in patients with schwannomas. Hearing loss is less prevalent and cerebellar signs and facial paresis are more common as presenting features. Hydrocephalus is often present in patients presenting with cerebellopontine angle meningiomas. Non-acoustic tumours can usually be resected with facial nerve preservation.  (+info)

Medullomyoblastoma: A case report. (7/828)

Medullomyoblastoma is a rare tumour seen in childhood. We report a medullomyoblastoma occurring in the cerebellar vermis of a 4 year old boy. The light microscopic features, immunohistochemistry and histogenesis are described.  (+info)

Choroid plexus papilloma of cerebellopontine angle with extension to foramen magnum. (8/828)

A case of choroid plexus papilloma resembling meningioma of cerebellopontine (CP) angle with its extension to foramen magnum is presented. Occurrence of this tumour in CP angle is very rare. Its extension towards foramen magnum is further rare. It was a real diagnostic enigma preoperatively as the tumour was resembling meningioma upto some extent on radiological study. Retromastoid craniectomy with microsurgical excision of tumour and its extension was achieved in toto. Tumour was attached to few rootlets of lower cranial nerves which were preserved. Attachment of the tumour with lower cranial nerves again caused diagnostic confusion with neurofibroma intraoperatively.  (+info)

*List of MeSH codes (C10)

... brain stem neoplasms MeSH C10.228.140.211.500.200 --- cerebellar neoplasms MeSH C10.228.140.211.692 --- neurocytoma MeSH ... pituitary neoplasms MeSH C10.228.140.252 --- cerebellar diseases MeSH C10.228.140.252.190 --- cerebellar ataxia MeSH C10.228. ... brain stem neoplasms MeSH C10.551.240.250.400.300 --- cerebellar neoplasms MeSH C10.551.240.250.550 --- neurocytoma MeSH ... spinal cord neoplasms MeSH C10.551.240.750.200 --- epidural neoplasms MeSH C10.551.360.500 --- optic nerve neoplasms MeSH ...

*List of MeSH codes (C04)

... brain stem neoplasms MeSH C04.588.614.250.195.411.211 --- cerebellar neoplasms MeSH C04.588.614.250.195.648 --- neurocytoma ... nose neoplasms MeSH C04.588.149.721.656 --- orbital neoplasms MeSH C04.588.149.721.828 --- skull base neoplasms MeSH C04.588. ... anal gland neoplasms MeSH C04.588.274.476.411.445 --- duodenal neoplasms MeSH C04.588.274.476.411.501 --- ileal neoplasms MeSH ... femoral neoplasms MeSH C04.588.149.721 --- skull neoplasms MeSH C04.588.149.721.450 --- jaw neoplasms MeSH C04.588.149.721. ...

*Cerebellar vermis

... and neoplasms. In neonates, hypoxic injury to the cerebellum is fairly common, resulting in neuronal loss and gliosis. Symptoms ... The cerebellar vermis (Latin for worm) is located in the medial, cortico-nuclear zone of the cerebellum, which resides in the ... The cerebellar vermis evolved in conjunction with the hemispheres; this is seen in lampreys and higher vertebrates. In ... Coffman, K. a, Dum, R.P. & Strick, P.L. (2011). "Cerebellar vermis is a target of projections from the motor areas in the ...

*Ectopic salivary gland tissue

... cerebellar pontine angle, soft tissue medial to sternocleidomastoid, stomach, rectum and vulva. Salivary gland neoplasm ...

*List of diseases (P)

... familial Pancreatic diseases Pancreatic islet cell neoplasm Pancreatic islet cell tumors Pancreatic lipomatosis duodenal ... dystrophy Proximal myotonic myopathy Proximal spinal muscular atrophy Proximal tubulopathy diabetes mellitus cerebellar ataxia ... et varioliformis acuta Pityriasis rubra pilaris Piussan-Lenaerts-Mathieu syndrome Placenta disorder Placenta neoplasm Placental ... virus type 3 antenatal infection Paramyotonia congenita of von Eulenburg Paramyotonia congenita Paraneoplastic cerebellar ...

*Balance disorder

... cerebellar dysfunctions and/or ataxia, or some tumors, such as acoustic neuroma. Individual treatment will vary and will be ... Vitamin B12 deficiency CNS or posterior neoplasms, benign or malignant Neurological: Vertiginous epilepsy, abasia Other - There ... cerebral or cerebellar ischemia or hypoperfusion, stroke, lateral medullary syndrome (Wallenberg's syndrome) Autoimmune: Cogan ...

*Neuronal lineage marker

In pathological conditions was also reported that glial neoplasms and reactive glial cells expressed this marker. Calretinin is ... Calbindin is expressed by cerebellar Purkinje cells and granule cells of hippocampus. The reorganization and migration of ...

*List of diseases (C)

Cerebellar agenesis Cerebellar ataxia areflexia pes cavus optic atrophy Cerebellar ataxia ectodermal dysplasia Cerebellar ... Carrington syndrome Cartilage-hair hypoplasia Cartilage hair hypoplasia like syndrome Cartilaginous neoplasms Cartwright-Nelson ... dominant pure Cerebellar degeneration, subacute Cerebellar degeneration Cerebellar hypoplasia endosteal sclerosis Cerebellar ... hypoplasia tapetoretinal degeneration Cerebellar hypoplasia Cerebellar parenchymal degeneration Cerebelloolivary atrophy ...

*List of diseases (T)

Temtamy-Shalash syndrome TEN Ter Haar-Hamel-Hendricks syndrome Ter Haar syndrome Teratocarcinosarcoma Teratoma Testes neoplasm ... palmoplantar keratoderma Thrombasthenia Thrombocytopathy asplenia miosis Thrombocytopathy Thrombocytopenia cerebellar ... mental retardation Thymic carcinoma Thymic epithelial tumor Thymic renal anal lung dysplasia Thymoma Thymus neoplasm ... syndrome Tolosa-Hunt syndrome Toluene antenatal infection Tomaculous neuropathy Tome-Brune-Fardeau syndrome Tongue neoplasm ...

*Pilocytic astrocytoma

The neoplasm will be clearly visible. If a tumor is found, it will be necessary for a neurosurgeon to perform a biopsy of it. ... Children with cerebellar pilocytic astrocytoma may experience side effects related to the tumor itself depending on the ... The neoplasm may also be solid. Under the microscope, the tumor is seen to be composed of bipolar cells with long "hairlike" ... The neoplasms are associated with the formation of a single (or multiple) cyst(s), and can become very large. Pilocytic ...

*List of diseases (L)

Lambert-Eaton paraneoplastic cerebellar degeneration) Lambert-Eaton syndrome Lamellar ichthyosis Lamellar recessive ichthyosis ... Lymph node neoplasm Lymphadenopathy, angioimmunoblastic with dysproteinemia Lymphangiectasies lymphoedema type Hennekam type ... isolated Lissencephaly Listeria infection Listeriosis Livedoid dermatitis Liver cirrhosis Liver neoplasms Lobar atrophy of ... pulmonary Lymphangiomyomatosis Lymphatic filariasis Lymphatic neoplasm Lymphedema distichiasis Lymphedema hereditary type 1 ...

*List of diseases (B)

... syndrome Braddock-Jones-Superneau syndrome Bradykinesia Brain cavernous angioma Brain neoplasms Brain stem neoplasms Branchial ... Brachydactyly long thumb type Brachydactyly mesomelia mental retardation heart defects Brachydactyly nystagmus cerebellar ... Black piedra Bladder neoplasm Blamronesis Blaichman syndrome Blastoma Blastomycosis Blepharitis Blepharo cheilo dontic syndrome ... craniosynostosis proptosis hydrocephalus Bone marrow failure neurologic abnormalities Bone marrow failure Bone neoplasms Bone ...

*List of ICD-9 codes 320-359: diseases of the nervous system

Primary cerebellar degeneration (334.3) Other cerebellar ataxia (334.4) Cerebellar ataxia in diseases classified elsewhere ( ... Neoplasm related pain (acute) (chronic) (338.4) Chronic pain syndrome (339) Other headache syndromes (339.0) Cluster headaches ...

*Intention tremor

The most common site for cerebellar lesions that lead to intention tremors has been reported to be the superior cerebellar ... Focal lesions such as neoplasms, tumors, hemorrhages, demyelination, or other damage may be causing dysfunction of the ... Depending on the location of cerebellar damage, these tremors can be either unilateral or bilateral. A variety of causes have ... "Cerebellar Tremor-Definition and Treatment." The Colorado Neurological Institute Review. Fall 2005. [2] National Institute of ...

*Astroblastoma

... often mistaking astroblastoma with glial neoplasms, high-grade astrocytes, and embryonal neoplasms. However, the "bubbly" ... The mass began at the brainstem, extended along the inferior cerebellar peduncle to roof areas against the ventricles through ... Neoplasm Neuroepithelial cell Astrocytes Glial cells Brain cancer REDIRECT Template:Curlie From a page move: This is a redirect ... Furthermore, the absence of chromosome function in 9q, 10, and X were not observed in other types of neoplasms, such as an ...

*List of cancer types

Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ... Heart cancer Astrocytoma Brainstem glioma Pilocytic astrocytoma ependymoma primitive neuroectodermal tumor Cerebellar ...

*List of MeSH codes (C23)

... neoplasm seeding MeSH C23.550.727.650.895 --- neoplasms, unknown primary MeSH C23.550.727.655 --- neoplasm recurrence, local ... cerebellar ataxia MeSH C23.888.592.350.090.600 --- gait ataxia MeSH C23.888.592.350.110 --- athetosis MeSH C23.888.592.350.200 ... neoplasm metastasis MeSH C23.550.727.650.560 --- lymphatic metastasis MeSH C23.550.727.650.645 --- neoplasm circulating cells ... MeSH C23.550.727.670 --- neoplasm regression, spontaneous MeSH C23.550.727.700 --- neoplasm, residual MeSH C23.550.737.500 --- ...

*Cerebritis

Severe lupus cerebritis symptoms include psychosis, dementia, peripheral neuropathy, cerebellar ataxia (failure of muscular ... and cannot reliably be distinguished from neoplasms. Cerebritis usually occurs as a result of an underlying condition, which ...

*List of diseases (S)

Subacute cerebellar degeneration Subacute sclerosing leucoencephalitis Subacute sclerosing panencephalitis Subaortic stenosis ... muscular atrophy Spinal atrophy ophthalmoplegia pyramidal syndrome Spinal cord disorder Spinal cord injury Spinal cord neoplasm ... corneal dystrophy Spinocerebellar degenerescence book type Spirochetes disease Spirurida infections Spleen neoplasm Splenic ...

*WHO classification of tumours of the central nervous system

3.4 Other neoplasms related to the meninges 3.4.1 Haemangioblastoma (ICD-O 9161/1, WHO grade I) 4.1 Malignant Lymphomas (ICD-O ... 1.7.9 Cerebellar liponeurocytoma (ICD-O 9506/1, WHO grade II) 1.7.10 Papillary glioneuronal tumour (ICD-O 9509/1, WHO grade I) ...

*List of diseases (A)

Abdominal neoplasms Aberrant subclavian artery Ablepharon macrostomia syndrome Abnormal systemic venous return Abruzzo-Erickson ... hypertension Anguillulosis Aniridia absent patella Aniridia ataxia renal agenesis psychomotor retardation Aniridia cerebellar ... X-linked Adrenal hypoplasia Adrenal incidentaloma Adrenal insufficiency Adrenal macropolyadenomatosis Adrenal medulla neoplasm ... Abdominal cystic lymphangioma Abdominal defects Abdominal musculature absent microphthalmia joint laxity Abdominal neoplasm / ...

*ICD-10 Chapter IX: Diseases of the circulatory system

Neoplasms (C00-D49) Symptoms, signs, and abnormal clinical and laboratory findings, NEC (R00-R94) Systemic connective tissue ... Occlusion and stenosis of cerebellar arteries (I66.4) Occlusion and stenosis of multiple and bilateral cerebral arteries (I66.5 ...

*Gluten-sensitive enteropathy-associated conditions

Mauro A, Orsi L, Mortara P, Costa P, Schiffer D (1991). "Cerebellar syndrome in adult celiac disease with vitamin E deficiency ... also EATL is the most common neoplasm. Squamous carcinoma of the esophagus is more prevalent in coeliac disease. The increased ...

*JC virus

2005). "Assessment of JC polyoma virus in colon neoplasms". Dis. Colon. Rectum. 48 (1): 86-91. doi:10.1007/s10350-004-0737-2. ... ultimately causing severe cerebellar atrophy. This syndrome, called JCV granule cell layer neuronopathy (JCV GCN), is ...

*ICD-10 Chapter VI: Diseases of the nervous system

Early-onset cerebellar ataxia Early-onset cerebellar ataxia with essential tremor Early-onset cerebellar ataxia with myoclonus ... Neoplasms (C00-D49) Symptoms, signs, and abnormal clinical and laboratory findings, NEC (R00-R94) List of ICD-10 codes ... Late-onset cerebellar ataxia (G11.3) Cerebellar ataxia with defective DNA repair Ataxia telangiectasia (Louis-Bar) (G11.4) ... Cerebellar stroke syndrome (G46.5) Pure motor lacunar syndrome (G46.6) Pure sensory lacunar syndrome (G46.7) Other lacunar ...

*Osteosarcoma

Overall survival prognosis is about 30%. Deaths due to malignant neoplasms of the bones and joints account for an unknown ... "Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog". Journal of Veterinary ... Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Sequelae in children following cerebellar tumor removal surgery are well defined, and predictors for poor recovery include lesions of the cerebellar nuclei and the inferior vermis. Dynamic reorganization is thought to promote functional recovery in p
At the same time discount suprax 100mg without prescription antibiotic resistance research funding, two other fissures deep- en on the inferior aspect of the vermis purchase suprax 100 mg with visa bacteria 2014, the secondary fissure and the prepyramidal fissure discount arava 10 mg overnight delivery, limiting the uvula and the pyramid respectively. Meanwhile the cerebellar mass, especially the cerebellar hemi- spheres, develops to cover the inferior vermis, which becomes buried deeply within the vallecula. Phylogenetically and ontogenetically, the postero- lateral fissure is the first to appear, separating the flocculonodular lobe, which is constant in most ver- tebrates, from the cerebellar mass, which increases in size from lower to higher vertebrates. Posteriorly and in- flocculus of mammals is the homologue of the hu- feriorly a narrow median fossa, the vallecula cerebel- man tonsil and the biventer lobule of the human cer- li, separates the hemispheres and contains the falx ebellum. ...
Source. Diagnosis. In case you feel that something can be wrong with your health, schedule an appointment with your doctor. The physician will ask you about your symptoms and in case he has reasons to suspect that you may suffer from a cerebellar condition, you will be referred to a neurologist. This specialist will test reflexes, as well as hearing and vision. A magnetic resonance imaging test, as well as a computerized tomography may be recommended to confirm the suspicion in the diagnosing process. Additional tests may be performed with the purpose to measure the tumors activity, as well as to determine if it is cancerous or not.. Treatment. In most cases, specialists are going to recommend the surgical removal of the tumor found in the cerebellum. In case the tumor has started to spread, it can only be partially removal or may cause additional damage to the body, radiation and chemotherapy can also be recommended.. ...
HPLC-MS/MS phosphoproteomics Analysis of human medulloblastoma cell line (DAOY cell line). 15 minutes treatment with SAG, vismodegib, EGF. TMT 10 plex experiment. 13 HILIC fractions measured using Qexactive HF. Knime Workflow. ...
Medulloblastoma (MB) is the most common malignant childhood brain tumor and high neurotrophin (NP) receptor TrkC mRNA expression was identified as a powerful independent predictor of favorable survival outcome. In order to determine downstream effector proteins of TrkC signaling, the MB cell line DAOY was stably transfected with a vector containing the full-length TrkC cDNA sequence or an empty vector control. A proteomic approach was used to search for expressional changes by two mass spectrometric methods and immunoblotting for validation of significant results. Multiple time points for up to 48 h following NP-3-induced TrkC receptor activation were chosen. Thirteen proteins from several pathways (nucleoside diphosphate kinase A, stathmin, valosin-containing protein, annexin A1, dihydropyrimidinase-related protein-3, DJ-1 protein, glutathione S-transferase P, lamin A/C, fascin, cofilin, vimentin, vinculin, and moesin) were differentially expressed and most have been shown to play a role in ...
Title: The Gene Expression Profiles of Medulloblastoma Cell Lines Resistant to Preactivated Cyclophosphamide. VOLUME: 8 ISSUE: 3. Author(s):M. D. Bacolod, S. M. Lin, S. P. Johnson, N. S. Bullock, M. Colvin, D. D. Bigner and H. S. Friedman. Affiliation:Cornell University Weill Medical College, New York, NY 10021, USA.. Keywords:Cyclophosphamide, drug resistance, medulloblastoma, brain tumor, oxazaphosphorine, aldehyde dehydrogenase, microarray, aldo-keto reductase. Abstract: The total expression profiles of two medulloblastoma cell lines resistant to the preactivated form of cyclophosphamide (4-hydroperoxycyclophosphamide, 4-HC) were examined using the Affymetrix GeneChip U133A array. Our primary objective was to look for possible genes, other than the well-studied aldehyde dehydrogenases (ALDH) that may be involved in cyclophosphamide (CP) resistance in medulloblastomas. We present here the lists of the most highly upregulated [30 for D341 MED (4-HCR); 20 for D283 MED (4-HCR)] and downregulated ...
A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).
This article collates information about the number of scientific articles mentioning each of the established medulloblastoma cell lines, derived through a systematic search of Web of Science, Scopus and Google Scholar in 2016. The data for each cell line have been presented as raw number of citations, percentage share of the total citations for each search engine and as an average percentage between the three search engines. In order to correct for the time since each cell line has been in use, the raw citation data have also been divided by the number of years since the derivation of each cell line. This is a supporting article for a review of in vitro models of medulloblastoma published in "in vitro models of medulloblastoma: choosing the right tool for the job" (D.P. Ivanov, D.A. Walker, B. Coyle, A.M. Grabowska, 2016) [1].. ...
Constitutive phosphorylation of Chk1 at serine 317 in a medulloblastoma cell line is sensitive to the inhibition of the phosphatidyalinositol-3-kinase-related kinase (PIKK) pathway
Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of dissemination are poorly understood and metastatic lesions are genetically divergent from the matched primary tumor. Effective and less toxic therapies that target both compartments have yet to be identified. Here we report that the analysis of several large non-overlapping cohorts of medulloblastoma patients reveal MET kinase as a marker of sonic hedgehog (SHH) driven medulloblastoma. Immunohistochemical analysis of phosphorylated, active MET kinase in an independent patient cohort confirmed its correlation with increased tumor relapse and poor survival, suggesting that SHH medulloblastoma patients may benefit from MET-targeted therapy. In support of this hypothesis, we found that the approved MET inhibitor foretinib could suppress MET activation, decrease tumor cell proliferation and induce apoptosis in SHH medulloblastomas in vitro and in vivo. ...
The goal of the Johns Hopkins Brain Cancer Biology and Therapy Laboratory is to locate the genetic and genomic changes that lead to brain cancer. These molecular changes are evaluated for their potential as therapeutic targets and are often mutated genes, or genes that are over-expressed during the development of a brain cancer. The brain cancers that the Riggins Laboratory studies are medulloblastomas and glioblastomas. Medulloblastomas are the most common malignant brain tumor for children and glioblastomas are the most common malignant brain tumor for adults. Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. Our laboratory uses large-scale genomic approaches to locate and analyze the genes that are mutated during brain cancer development. The technologies we now employ are capable of searching nearly all of a cancer genome for molecular alterations that can lead to cancer. The new molecular targets for cancer therapy are first located by l...arge ...
PRIMARY OBJECTIVES:. I. Estimate of the progression free survival (PFS) distribution for patients 0-,4 years of age with M0 desmoplastic medulloblastoma (nodular desmoplastic or medulloblastoma with extensive nodularity) treated with the modified HIT SKK regimen (excluding the use of intraventricular methotrexate).. SECONDARY OBJECTIVES:. I. Evaluate the feasibility of a rapid central pathology screening review for treatment allocation according to histology and assess agreement between institutional and central pathology review diagnoses as well as among central pathology review diagnoses.. II. Prospectively evaluate the molecular profile of nodular desmoplastic (ND)/medulloblastoma with extensive nodularity (MBEN) medulloblastoma in young children.. III. Monitor and describe the neurocognitive and adaptive functioning of young children with ND/MBEN medulloblastoma treated on this protocol using the ALTE07C1 protocol.. OUTLINE:. INDUCTION THERAPY: Patients receive vincristine sulfate ...
Published June 2015. ISBN: 978-1-78084-396-4. Medulloblastomas are highly malignant cerebellar tumors. Approximately 80% of medulloblastomas are diagnosed in children younger than 15 years of age, and they are among the leading causes of pediatric cancer deaths. Remarkable advances in survival have been achieved in the past two decades using a combination of surgery, chemotherapy, radiation and bone marrow rescue. However, this improvement in outcome is attained at a high cost to quality of life due to the aggressive treatment regimens, and many patients succumb to their disease and/or its recurrence. The five chapters of this book provide a comprehensive, but straightforward, up-to-date reference for medical students, residents and fellows, and other healthcare professionals, as well as basic science researchers with an interest in pediatric medulloblastomas.. ...
Medulloblastomas are highly malignant cerebellar tumors. Approximately 80% of medulloblastomas are diagnosed in children younger than 15 years of age, and they are among the leading causes of pediatric cancer deaths. Remarkable advances in survival have been achieved in the past two decades using a combination of surgery, chemotherapy, radiation and bone marrow rescue. However, this improvement in outcome is attained at a high cost to quality of life due to the aggressive treatment regimens, and many patients succumb to their disease and/or its recurrence. The five chapters of this book provide a comprehensive, but straightforward, up-to-date reference for medical students, residents and fellows, and other healthcare professionals, as well as basic science researchers with an interest in pediatric medulloblastomas.. ...
Medulloblastomas are the most common malignant brain tumours in children. Identifying and understanding the genetic events that drive these tumours is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct molecular subtypes of medulloblastoma on the basis of transcriptional and copy number profiles. Here we use whole-exome hybrid capture and deep sequencing to identify somatic mutations across the coding regions of 92 primary medulloblastoma/normal pairs. Overall, medulloblastomas have low mutation rates consistent with other paediatric tumours, with a median of 0.35 non-silent mutations per megabase. We identified twelve genes mutated at statistically significant frequencies, including previously known mutated genes in medulloblastoma such as CTNNB1, PTCH1, MLL2, SMARCA4 and TP53. Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, ...
Daniel RA, Rozanska AL, Mulligan EA, Drew Y, Thomas HD, Castelbuono DJ, Hostomsky Z, Plummer ER, Tweddle DA, Boddy AV, Clifford SC, Curtin ...
As a matrix for invasion we used freshly prepared cerebellar parenchyma. Cut in 40 m - slices, it was fixed to a membrane only by mechanical manners, maintaining its structure without any chemical treatment for preservation. Spheroids of two established human medulloblastoma cell lines (MHH-Med 4, MEB-Med 8S), whose invasive potential in other assay systems is poor, were studied for their invasiveness into the brain-slice within 24 hours, as well as the optimal conditions for preservation of the slice. Vincristin, which blocks glioma cell motility, was used for negative controls.. ...
Developing new, less toxic approaches to treatment is critical to advancing therapy for medulloblastoma, the most common malignant brain tumor in children. While many medulloblastoma patients achieve long-term survival through combined radiation and chemotherapy, this treatment causes long-term neuro-cognitive impairment and significant risk of incurable recurrence. The early age of onset of medulloblastoma has prompted a growing consensus to examine the processes that support developmental brain growth as potential oncogenic mechanisms that may be targeted in novel therapies. Our recent work demonstrates that energy metabolism, DNA repair and control of apoptosis are developmentally regulated to support proliferation during cerebellar growth, and become co-opted in medulloblastoma formation. Our ongoing projects build on these observations, using mouse genetics and primary tumor modeling to learn:. ...
Treatment of pediatric medulloblastoma, the most common malignant tumor of the CNS in children, requires a combination of surgical excision, radiation therapy, and chemotherapy. Prior research has documented ototoxicity and middle ear disease in 25% to 90% of patients treated with multimodality therapy.5, 7, 11 At this institution, pediatric medulloblastoma patients receive a cumulative cisplatin dose of 300 mg, decreased from the standard of 600 mg. Early analysis suggests that this reduction may minimize ototoxic sequelae, however long-term data on SNHL is lacking. Further, the percentage of patients in this population that will ultimately qualify for cochlear implantation has not yet been documented.. Damage to the auditory system from chemotherapeutic agents, specifically platinum-based compounds, as well as radiation therapy is well documented. Cisplatinum ototoxicity is typically characterized by irreversible, bilateral, symmetric, high-frequency SNHL.5, 7 Ototoxicity can be related to ...
Objective: Medulloblastoma (MB), the most common malignant pediatric brain tumor, is comprised of four subgroups (WNT, SHH, Group 3, Group 4). While recurrent single nucleotide variations is rare in MB, mutation of epigenetic modifiers is frequent, suggesting a mechanism for tumorigenesis. Genetically engineered mouse models (GEMMs) recapitulate some aspects of MB, but fail to replicate the epigenetics characteristic of human MB. Therefore, we aimed to develop the first human stem cell based model of MB using iPSC derived from Gorlin syndrome (GS), a disease that predisposes patients to SHH MB due to heterozygosity for PTCH1 ...
Assuming that the fundamental feature of cancer is genomic instability, functional defects of proteins which are responsible for maintenance of genome integrity by correcting DNA replication errors, should be carcinogenic. It is therefore not surprising that a number of cancer susceptibility genes encode key factors of DNA repair pathways. Recent comprehensive analysis of germline mutations in pediatric cancers pointed to DNA repair genes as the most commonly mutated genes, including TP53 and BRCA2 [43]. It is also increasingly clear that defects in DNA repair genes may determine patients response to radio and chemotherapy [13, 16, 17]. In view of that we evaluated the potential association between DNA repair defects and treatment related toxicity as well as their potential role as a susceptibility factor for medulloblastoma.. The sequence analysis of two well-known repair genes MSH2 and RAD50 conducted in large cohort of 102 medulloblastoma patients revealed three new germline variants MSH2 ...
Investigators at St. Jude Childrens Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor.
3885 Medulloblastomas are malignant brain tumors that arise in the cerebellum in children. Aberrant activation of the Sonic Hedgehog (Shh) signaling pathway, which normally stimulates proliferation of granule neuron precursors (GNPs) during cerebellar development, induces tumors in mice that closely mimic human medulloblastomas. Shh-dependent medulloblastoma formation is enhanced by hyperactive insulin-like growth factor (IGF) signaling and ectopic expression of Myc oncogenes. This enhanced tumorigenesis stems from the sensitivity of GNPs to IGF and Myc levels in regulating proliferation. An emerging theme in cancer research is that oncogene-induced cell proliferation cannot initiate neoplastic transformation unless cellular programs that mediate apoptosis are disabled. We modeled the ability of the anti-apoptotic protein Bcl-2 to induce medulloblastoma in vivo using the RCAS/tv-a system, which allows postnatal gene transfer and expression in a cell type-specific manner. We targeted expression ...
Medulloblastoma is the most common malignant pediatric brain tumor. While current treatments have improved survival, survivors face high risk of recurrence and...
Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments for this disease include surgery, cranio-spinal radiation and chemotherap...
Medulloblastoma occurs in infants, children and adults, but it is the most common malignant pediatric brain tumor, of which Group 4 is the most common.
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Gurreiro, A. Iidentification of new molecular targets for human medulloblastoma using an RNA interference screen. 2009, University of Zurich, Faculty of Medicine. ...
View Notes - DIAG 2740 Chapter 15 Outline from DIAG 2740 at Life Chiropractic College West. SCA infarct: PICA and AICA: Cerebellar tumor: Medulloblastoma Signs: Cerebellar Multiple Sclerosis
Laboratory for Childhood Brain Tumor Research. Medulloblastoma is the most common malignant brain tumor in children and one of the leading causes of death in this age group. Over one-third of children with medulloblastoma die within 5 years of diagnosis and the vast majority of survivors have significant neurological deficits due to the toxicity of combined surgery, radiation, and chemotherapy. To improve survival and minimize side effects of current therapy, a more detailed understanding of the biology of medulloblastoma will better characterize the disease and will aid in prognosis and in identification of novel treatments.. Cancer, in general, is a disease that is believed to originate sporadically from one or a few cells within a tissue. After a cell acquires genetic mutations over time, the cell then has a growth advantage over normal surrounding cells in the tissue, and has the potential to become cancerous. Current mouse models of cancer, including those for medulloblastoma, have been ...
Medulloblastomas fall under the category of poorly differentiated neoplasms: with this particular type of brain tumour, it is difficult for a pathologist (histopathologist) to find any cells that resemble mature brain cells. It is most common within children, where it accounts for approximately one fifth of paediatric brain tumours.. What is the prognosis for those with medulloblastoma? The tumours are malignant in nature, and therefore the prognosis is dismal for those left untreated. However, the situation improves massively if the tumours are treated by means of a combined attack of chemotherapy and surgery as the cells are very sensitive to radiation. Approximately three quarters of patients that are treated manage to survive for approximately 5 years.. Where are medulloblastomas located within the brain? Medulloblastomas are chiefly located within the cerebellum, but they may also be found elsewhere in the nervous system. In children, the tumours are often seen in the midline of the ...
Medulloblastoma is the most common malignant brain tumor in childhood, displaying tremendous biological and clinical heterogeneity. Four biological subgroups are consistently revealed in various studies based on gene expression profiling, but details of the genetic events driving each of these subgroups remain elusive. We have performed an integrative deep-sequencing analysis to identify genetic alterations in 200 tumor-normal pairs. Strikingly, tetraploidy was found to be a common early event in clinically challenging Group 3 & 4 tumours. For SHH tumors in contrast, we have identified a subgroup of tumors in older children that show striking patterns of chromothripsis, all of which have underlying TP53 mutations, either early somatic or germline. SHH tumors in adults, which are the predominant subgroup in this age group, in turn show a largely different mutation spectrum from their pediatric counterparts. Overall, beside known alterations (CTNNB1, PTCH1, MLL2, SMARCA4), several genes not ...
In chick chorioallantoic membrane (CAM) assays, injection of cilengitide into CAM vasculature prevented the growth of implanted U87MG glioma and DAOY medulloblastoma tumor fragments compared to the inactive peptide EMD135981. The inhibition of tumor growth was attributed to the anti-angiogenic activity of cilengitide as membrane vascularity surrounding the tumor graft was greatly decreased by cilengitide treatment as compared to the inactive control peptide [130]. In animal models, cilengitide, as a single agent effectively inhibited the growth and proliferation of orthotopically implanted malignant glioma and medulloblastoma cell lines in nude mice. Daily treatment of established xenografts with 100-200 µg cilengitide significantly delayed tumor growth and prolonged survival compared to controls. The delayed tumor growth was accompanied by increases in CD31 and tumor doubling times, elevated apoptotic index and decreases in proliferative index and tumor vessel number and density [130]. ...
A major goal of our work is to study medulloblastoma biology to facilitate the development of targeted therapy. Here, we have dissected the contribution of epigenetics to tumor development. Epigenetic perturbations are pharmacologically reversible and may have therapeutic potential. The RE1-Silencing Transcription Factor (REST) is an epigenetic modulator, and a repressor of neuronal differentiation genes. Its expression is significantly elevated in human medulloblastomas, and is associated with poor prognosis. REST is a driver of medulloblastoma in mouse orthotopic models. To understand RESTs contribution to tumor development, we created a novel genetically engineered mouse model in which REST transgene is conditionally elevated in the cerebellar granule progenitors (GNPs), the cells of origin of some medulloblastoma. Transgene induction caused GNP hyperproliferation, accompanied by a failure to express the cell cycle regulator-p27. Using genetic and biochemical approaches, we attributed the ...
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC. Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. The Lancet Oncology 2017, 18(7), 958-971 ...
LY2940680 administered orally once daily at escalating doses (92.5 milligrams per square meter [mg/m^2] up to 370 mg/m^2) for two 28 day cycles. Lower dose levels (23 mg/m^2 and 46 mg/m^2) may also be explored, if necessary. Participants receiving benefit may continue until disease progression, unacceptable toxicity, or discontinuation ...
To analyse the histo-morphology of cases of medullomyoblastoma and identifying its divergent differentiation. A retrospective review of all cases reported as medulloblastoma between the period of Jan 2000 to Dec 2006 was carried out on Hematoxylin and eosin (H & E) stained slides. The cases were screened on light microscopy for primitive neuroectodermal component of a medulloblastoma accompanied by areas of myoid differentiation, identified on the basis of presence of strap cells (indicating a clear skeletal muscle differentiation) and/or large anaplastic cells with vescicular nuclei and moderate to abundant amount of eosinophilic cytoplasm. All these cases were subjected to a panel of immunohistochemical stains, including Desmin, GFAP, NFP, HMB45, SMA, S100, CK and EMA. Ultrastructral analysis was done on tissue obtained from paraffin blocks in 2 cases. Male predominance (M:F = 5:1) was noted with an incidence of five percent of all cases of medulloblastoma (6 out of 120 cases) over a period of 6
Expert-reviewed information summary about the treatment of childhood medulloblastoma, nonmedulloblastoma embryonal tumors, and pineal tumors.
Expert-reviewed information summary about the treatment of childhood medulloblastoma, nonmedulloblastoma embryonal tumors, and pineal tumors.
Medulloblastoma arises from mutations occurring in stem/progenitor cells located in restricted hindbrain territories. Here we report that the mouse postnatal ventricular zone lining the IV ventricle also harbors bona fide stem cells that, remarkably, share the same molecular profile with cerebellar white matter-derived neural stem cells (NSC). To identify novel molecular mediators involved in medulloblastomagenesis, we compared these distinct postnatal hindbrain-derived NSC populations, which are potentially tumor initiating, with murine compound Ptch/p53 mutant medulloblastoma cancer stem cells (CSC) that faithfully phenocopy the different variants of human medulloblastoma in vivo. Transcriptome analysis of both hindbrain NSCs and medulloblastoma CSCs resulted in the generation of well-defined gene signatures, each reminiscent of a specific human medulloblastoma molecular subclass. Most interestingly, medulloblastoma CSCs upregulated developmentally related genes, such as Ebfs, that were shown ...
In the journal Cancer Research, UNC Lineberger researchers led by member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify a suitable therapeutic target within the sugar metabolism pathway, and provide clues to a scientific mystery surrounding the confounding way that some cancer cells get energy from sugar. ...
1. Although surgery remains the major treatment for medulloblastoma, there is still controversy regarding the impact of resection on the prognosis of patients with medulloblastoma. Furthermore, in cases of adherent medulloblastoma to the brainstem, complete resection is extremely difficult. In addition, metastasis via the cerebrospinal fluid is common; thus, medulloblastoma patients often have a poor prognosis and a high mortality rate 2.. Clinically, the prognosis of patients with medulloblastoma is often determined according to the pathological type, which also provides a reference for the application of adjunctive therapies, such as radiotherapy and chemotherapy 3,4. Currently, the World Health Organization (WHO) classification system for medulloblastoma is based on histomorphology. However, patients with the same pathological type of medulloblastoma still have distinct genetic backgrounds. Therefore, the prognosis of patients with medulloblastoma may vary even within the same WHO ...
TY - JOUR. T1 - A fibrotic nodule arising from the cerebellopontine angle. AU - Amano, Toshiyuki. AU - Suzuki, Satoshi. AU - Mizoguchi, Masahiro. AU - Yoshimoto, Koji. AU - Nakamizo, Akira. AU - Murata, Hideki. AU - Iwaki, Toru. AU - Sasaki, Tomio. PY - 2013/4/1. Y1 - 2013/4/1. N2 - The authors present an extremely rare case of a fibrotic nodule arising from the cerebellopontine (CP) angle. A 57-year-old male had suffered from hearing disturbance and tinnitus for several years. Computed tomography revealed a high-density mass in the left CP angle with little enhancement after intravenous administration of contrast media. Magnetic resonance imaging (MRI) showed a very hypointense mass on T2-weighted imaging. T1-weighted MRI with gadolinium revealed very faint, delayed enhancement of the tumor. The patient underwent surgical resection of the tumor. Histopathologically the lesion comprised entirely fibrotic tissue consisting of thick collagenous fibers and sclerosing blood vessels with a few ...
A patient developed weakness of the right leg and homolateral ataxia of the arm, caused by a subcortical infarct in the area supplied by the anterior cerebral artery in the left paracentral region, demonstrated by CT and MRI. Cerebral blood flow studied by technetium-labelled hexamethyl-propylene-amine oxime using single photon emission computed tomography showed decreased blood flow in the left lateral frontal cortex and in the right cerebellar hemisphere ("crossed cerebral-cerebellar diaschisis"). The homolateral ataxia of the arm may be caused by decreased function of the right cerebellar hemisphere, because of a lesion of the corticopontine-cerebellar tracts, whereas crural hemiparesis is caused by a lesion of the upper part of the corona radiata.. ...
Clinical samples. Ethical approval to use residual tissue was obtained for all primary medulloblastoma samples used in this study. Forty-seven medulloblastoma samples collected at diagnosis in a single institution between 1992 and 2004 (Dr. Lellouch-Tubiana, Necker Hospital) according to the French law of bioethics (Loi Huriet) were used for gene expression analyses. Frozen tumor samples were placed into TRIzol reagent (Invitrogen) and homogenized and total RNA was isolated after DNase treatment using the RNeasy Micro kit (Qiagen).. An independent set of 19 RNAlater-preserved tumor tissues from the Swiss Pediatric Oncology Group Tumor Bank was obtained for mRNA and protein expression analysis. All diagnoses were confirmed by histologic assessment of the tumor specimen obtained at surgery. Medulloblastoma tissues were disrupted with a sterile disposable tissue grinder (Sage products) and homogenized in guanidinium isothiocyanate-containing buffer. Total RNA and protein of tumor tissues were ...
An imaging genomic map that links MR imaging traits with gene and microRNA (miRNA) expression profiles in patients with glioblastoma multiforme (GBM) was presented at RSNA 2013.. Researchers sought to identify genomic correlates of an MR perfusion radiophenotype in order to find new genomic targets for treatment of GBM, the most common malignant brain tumor. GBM accounts for 52 percent of all brain tumor cases affecting functional tissue and 20 percent of all intracranial tumors. Between 12,000 and 14,000 new GBM cases are diagnosed annually, and the five-year survival rate for GBM is among the worst for human cancers.. "Its a quite terrible diagnosis," said Rivka Colen, M.D., of The MD Anderson Cancer Center in Houston. She noted that despite ongoing efforts, there has been little significant progress in GBM therapy over the years.. But the relatively new field of imaging genomics, which links specific imaging traits (radiophenotypes) to genomic profiles, has the potential to effect changes in ...
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... is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the ...
Summary: Lhermitte-Duclos disease (LDD) MR imaging (MRI) revealed a nonenhancing mass in the right cerebellar hemisphere, which was characterized ...
Here we provide the first evidence that KDM1A plays a functional role in maintaining tumorigenic properties in medulloblasoma. Medulloblastomas, cell lines derived from medulloblastomas and meduloblastic tumors from genetically engineered mouse models for medulloblastoma exhibit high-level KDM1A expression in comparison to normal cerebellar tissue. KDM1A inhibition can effectively antagonize important hallmarks of medulloblastoma progression including proliferation, resistance to apoptosis and migration. BMP2 signaling via SMAD5 is a potentially important downstream effector of KDM1A functionality. Specific inhibition of KDM1A, for instance via the NCL-1 small molecule inhibitor, presents a promising new strategy to treat medulloblastoma, which should be clinically evaluated.. Chromatin modifiers influencing gene expression by histone acetylation or methylation are emerging as an interesting new approach to target cancers. Recently, several next-generation tumor sequencing projects have ...
This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating patients with WNT-driven medulloblastoma. However, there is a concern about the late side effects of treatment, such as learning difficulties, lower amounts of hormones, or other problems in performing daily activities. Giving reduced craniospinal radiation therapy and chemotherapy may kill tumor cells and may also reduce the late side effects of treatment.. Learn more at ClinicalTrials.gov NCT02724579. ...
Our previous work and that of other investigators strongly suggest a relationship between the upregulation of MMP-9 and uPAR and tumor angiogenesis and metastasis. In this study, we evaluated the role of MMP-9 and uPAR in medulloblastoma cancer cell resistance to ionizing irradiation (IR) and tested the anti-tumor efficacy of siRNA against MMP-9 (pM) and uPAR (pU) either alone or in combination (pUM). Cell proliferation (BrdU assay), apoptosis (in situ TUNEL for DNA fragmentation), and cell cycle (FACS) analyses were carried out to determine the effect of siRNA either alone or in combination with IR on G2/M cell cycle arrest in medulloblastoma cells. IR upregulated MMP-9 and uPAR expression in medulloblastoma cells; pM, pU, and pUM in combination with IR effectively reduced both MMP-9 and uPAR expression, thereby leading to increased radiosensitivity of medulloblastoma cells. siRNA treatments (pM, pU, and pUM) also promoted IR-induced apoptosis and enhanced IR-induced G2/M arrest during cell ...
The most frequent genetic alteration in medulloblastomas is isochromosome 17q, which occurs in up to 50% of cases (26, 27), whereas loss of heterozygosity on 17p13.3 is observed in 30% to 50% of medulloblastomas (1, 28, 29). Accordingly, comparative genomic hybridization revealed gain of 17q and loss of 17p as most frequent chromosomal imbalance (30-32). Mutations in the PTCH gene are found in 8% to 20% of cases, particularly in the desmoplastic variant (33-35). PTCH is an inhibitor of the Hedgehog signaling pathway, which is a major mitogenic factor in the development of the embryonic external granular cell layer of the cerebellum, from which most medulloblastomas are considered to originate (36). TP53 mutations are infrequent (5-10% of cases; refs. 1, 18), but most mouse models of medulloblastoma with high penetrance involve loss of p53 expression in addition to other knockout genes, including Ptch (37), Rb (38), PARP-1 (39), and Lig4 (40). Other pathway involved in the development of ...
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Expression of Mtss1 exons 11-13 in human medulloblastomas and medulloblastoma derived cell lines. A: Lanes 1-5: classical medulloblatoma samples D1198, D112
Pathology report showed medulloblastoma.This case shows the typical presentation and MRI imaging findings seen with medulloblastoma.As the probability of leptomeningeal / CSF seeding is considerable with medulloblastoma, further imaging of the ne...
To find out if the overall dose of radiation to the brain and spine can be reduced without decreasing rates of survival in children with medulloblastoma.
In the last few years, cancer researchers have recognized that medulloblastoma, a brain cancer that disproportionately affects children, consists of at least four molecular subtypes. A better understanding of those subtypes may help guide the development of targeted drug therapies and explain why up to 20% of patients experience recurrence after developing resistance to treatment.. Reporting in Nature Medicine, an international team of researchers linked decreased expression of GNAS, which encodes Gαs, a key player in G protein-coupled receptor signaling, to aggressive tumors in the medulloblastoma subtype driven by activation of the Sonic hedgehog (SHH) pathway. In mice, the researchers found that Gαs suppressed tumor growth. In addition, after studying samples of human medulloblastoma tissue from more than 200 patients-from cohorts in Boston, MA, and Heidelberg, Germany-they found that patients with low expression of GNAS had a lower overall survival time than patients with normal GNAS ...
Standard risk: Radiation treatment for standard-risk disease in children consists of craniospinal radiation of 2340 cGy plus a boost of 5400 cGy to the primary site of the tumor. Initially this boost was to the whole posterior fossa, but, more recently, conformal fields around the primary site of the tumor at diagnosis with a margin have been recommended. ...
Authors analyse their experience with the treatment of ninety-three cases of cerebello-pontine angle tumors. A trained team with an otologist and neurosurgeon can obtain best results, both functional and vital. The postero-trans-labyrinthine approach
The tumour was resected and histologically confirmed to be medulloblastoma. Medulloblastoma is typically a paediatric tumour that most commonly arises from the vermis. When seen in adults, however, they are more likely to arise in atypical loca...
A comprehensive analysis of the molecular characteristics of gliomas-the most common malignant brain tumor-explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while ...
The challenge in molecular-targeted therapeutics is to identify those signal transduction pathways on which cancer cells have become dependent for their growth and survival. By interrupting these pathways, oncologists hope to arrest tumor cell growth or induce apoptosis more effectively than can be accomplished using cytotoxic chemotherapy and radiation, which impede the growth of cancer cells via nonspecific DNA damage. An emerging theme in cancer therapeutics is that compounds that block specific signaling pathways will be maximally effective against tumors in which the targeted pathway is pathologically hyperactive. For that reason, it is important to test new therapeutic agents in experimental systems that allow the investigator to control which oncogenic signaling pathways are activated.. Models of human medulloblastoma using genetically engineered mice have shown that aberrant activation of the developmentally important Hedgehog signaling pathway in cerebellar neuron precursor cells could ...
... brain tumor medical case overview provided by Farhad Limonadi MD, neurosurgeon specialist in the Coachella Valley area of Southern California.
Expression of hsa-miR-367 and aggressiveness of human medulloblastoma. Scholarships in Brazil Master. Carolini Kaid Dávila. Interdisciplinary Subjects
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Hemangioblastoma
Brain tumors are the leading cause of death from cancer in children, and medulloblastoma is the most common type of malignant brain cancer.
One would like to think that tangibly better treatments for rhabdomyosarcoma, medulloblastoma and other childhood cancers can be found in a matter of years, instead of tens of years. Finding new treatments starts with research, perhaps even a new research approach to identifying effective new treatments. The Childrens Cancer Therapy Development Institute focuses on finding molecules in childhood cancers that can be directly turned off or on by drugs so that the tumor stops growing. Behind our novel approach is the use of genetically-engineered mice. Our Pediatric Preclinical Testing Initiative uses mice modified from before birth so that at a certain age, and in a certain tissue, the same mutations found in a childs cancer are activated in the mouse. These special mouse models of childhood cancer can be used to test a treatment to see whether the tumor growth and spread (metastasis) can be reversed. The specific aspect of these mice having normal immune systems is a real plus, too, because ...
in Revue Médicale de Liège (2007), 62(4), 200-4. We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed ... [more ▼]. We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed. Five years after diagnosis, the event-free survival was 77%. [less ▲]. Detailed reference viewed: 197 (2 ULiège) ...
...Between the blueprint of the genome and the products of its expression... For the past five years weve been looking at microRNAs in medullobl...When Vibhakar and colleagues inquired into the effects of lower microR...In fact the group found 618 genes whose expression was manipulated by...,MicroRNA-218,targets,medulloblastoma,,most,aggressive,childhood,brain,cancer,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
...Between the blueprint of the genome and the products of its expression... For the past five years weve been looking at microRNAs in medullobl...When Vibhakar and colleagues inquired into the effects of lower microR...In fact the group found 618 genes whose expression was manipulated by...,MicroRNA-218,targets,medulloblastoma,,most,aggressive,childhood,brain,cancer,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Medulloblastoma. Matt Harkenrider , MD June 10, 2010. History & Histology. History First described in 1925 in Bailey and Cushings classification of CNS tumors Slideshow 6699248 by merrill-bean
Bolin, Sara; Savov, Vasil; Borgenvik, Anna; Garancher, Alexandra; Rosen, Gabriela; Rahmanto, Aldwin Suryo; Hutter, Sonja; Rusert, Jessica; Fotaki, Grammatiki; Hill, Rebecca; Dubuc, Adrian; Remke, Marc; Cancer, Matko; Ramaswamy, Vijay; Clifford, Steve; Sangfelt, Olle; Schueller, Ulrich; Taylor, Michael; Wechsler-Reya, Robert; Weishaupt, Holger; Swartling, Fredrik (2017): Rare SOX9+CELLS behind MYC-Driven Medulloblastoma Recurrence. In: Neuro-Oncology, Vol. 19: pp. 260-261 ...
Progress Update from 1st year: 8/1/2014-7/30/2016 Millions of cells are formed every day in the developing brain of children. Medulloblastoma, the mos...
Here we present the history, staging system, and treatment of medulloblastoma, reviewing the prognostic value and clinical application of molecular subtyping while highlighting the differences between adult and pediatric disease. 1
Medulloblastoma Diagnostics (costs for program #29125) ✔ Academic Hospital Hildesheim ✔ Department of Spine Surgery ✔ BookingHealth.com
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial., The Lancet Oncology, vol.7,(10),2006,pp 813-820 ...
There are more negative prognostic factors in patients with R sided primary, in particular high BRAF MT, and these patients have inferior overall survival when compared to those with a L sided primary. There was no suggestion that site of primary had any impact on bevacizumab effect on PFS. 1SY Brule et al, J Clin Oncol 31, 2013 (supp #3528) 2MK Boisen et al, Ann Oncol 24, 2554-59 ...
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
A 7 year old boy from Remote village presented with complains of vomiting 4-5 episodes per day for 3 months, inability to walk without support for 20 days and
Malignant tumors formed from poorly developed cells at a very early stage of life. Usually occur in children between the ages of three and eights. More common in males than females. May also occur in adults although this is rare.
Colorectal cancer is not a homogenous disease, but it has different subgroups based on their molecular characteristics. NCCN and ESMO guidelines emphasize the importance of the determination of RAS and BRAF mutations in those patients who are intended to treat with targeted therapy. The increase in knowledge on the molecular changes will help to design and start a new generation of clinical trials, which will be designed not on their randomization of large groups of unselected patients, but rather on the consideration of the molecular subgroups determined before introducing therapy.. ...
This photo is from September 2010. I had just shaved my head for St. Baldricks in honor of my son Levi, pictured. He was diagnosed with stage 4 brain cancer (Medulloblastoma) in 2004 when he was only four. Surgery to remove the tumor left him mute, paralyzed and incontinent. He relearned all his life skills while undergoing multiple surgeries, chemotherapy and intense radiation. He is my hero. News on NewsHub.org
Symptoms of Lhermitte-Duclos disease including 4 medical symptoms and signs of Lhermitte-Duclos disease, alternative diagnoses, misdiagnosis, and correct diagnosis for Lhermitte-Duclos disease signs or Lhermitte-Duclos disease symptoms.
In Lhermitte-Duclos disease, the cerebellar cortex loses its normal architecture, and forms a hamartoma in the cerebellar hemispheres. The tumors are usually found on the left cerebellar hemisphere, and consist of abnormal hypertrophic ganglion cells that are somewhat similar to Purkinje cells. The amount of white matter in the cerebellum is diminished.. Like cowden syndrome, patients with Lhermitte-Duclos disease often have mutations in enzymes involved in the Akt/PKB signaling pathway, which plays a role in cell growth. Mutation in PTEN gene on chromosome no. 10q leads to increased activity of AKT and mTOR pathways.. ...
In the largest trial conducted for average-risk medulloblastoma, survival rates following reduced radiation therapy boost volumes were comparable to standard treatment volumes for the primary tumor site, but lower doses of craniospinal axis irradiation were associated with higher event rates and worse survival, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO).. Findings from a phase III randomized trial indicate that physicians can adopt smaller boost volumes for posterior fossa radiotherapy, but should maintain the standard radiotherapy dose for craniospinal irradiation (CSI).. The most common type of brain malignancy in children, medulloblastoma is an aggressive tumor that originates in the lower, rear area of the brain but has a propensity to spread to the upper brain and spine. As a result, the standard of care following surgical resection for these children has included systemic chemotherapy and irradiation to both the ...
Identifying the cellular origins of medulloblastoma - the most common malignant brain tumor in children - may help focus treatment on cell types responsible for tumor initiation. Previous research has linked Sonic hedgehog signaling in neuronal cell precursors within the developing cerebellum to medulloblastoma.. Now, Chin Chiang, Ph.D., and colleagues demonstrate that "turning on" Sonic hedgehog signaling in a different cell type - hindbrain roof plate cells - leads to medulloblastoma. The roof plate cells are a specialized tissue that function as a signaling center regulating neural patterning. Previous studies had suggested that the hindbrain roof plate was restricted in its potential and contributed only to non-neural choroid plexus epithelial cells.. The new studies, reported in April in PLoS ONE, demonstrate that the hindbrain roof plate contributes not only to choroid plexus but also to multiple neuronal and glial cell types in the cerebellum. The findings also show that hindbrain roof ...
The present study included cases of malignant brain tumours diagnosed during 2007-2009 from across Sweden. For the cases diagnosed during 1997-2003 in our previous study (5), the prevalence of use of mobile phones was highest in the age group 30-54 years for men, and 35-54 years for women. Thus, we included the age group 18-75 years in this study to allow for the longest possible latency time (28). This is in contrast to the Interphone study, which included cases aged 30-59 years. Glioma is the most common malignant brain tumour, and the most common glioma subtype is astrocytoma. Glioblastoma multiforme (WHO grade IV) accounts for 60-75% of all astrocytoma, in this study 66% of the cases with astrocytoma. The peak incidence is between 45-75 years, with a mean age of 61 years and with 80% older than 50 years (29). Thus, limiting the upper age to 59 years for cases as in Interphone (3) would diminish the possibility of finding an increased risk for the long-term use of mobile phones.. Recall and ...
The correlation of c-Myc expression with resveratrol-induced turnover of medulloblastoma cells was investigated in this study by checking (1) c-Myc expression in medulloblastoma tissues and cell lines (UW228-2 and UW228-3), (2) the in vitro effect of resveratrol on c-Myc expression and (3) the influences of c-Myc inhibition in cell growth and survival. Immunohistochemical staining of human medulloblastomas and noncancerous cerebellar tissues revealed that 8 out of 11 tumor tissues (72.7%) expressed c-Myc, in which 4 cases (50%) showed intensified nuclear labeling. RT-PCR, Western blotting, immunocytochemical and immunofluorescence stainings revealed c-Myc downregulation accompanied with growth suppression and apoptosis. Flow cytometry analysis showed S phase arrest in resveratrol-treated cell populations. Transfection of c-Myc directed antisense oligonucleotides to the cultured medulloblastoma cells could reduce c-Myc expression, inhibit cell growth and arrest the cell cycle at S phase. Our ...
Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of Sonic hedgehog, becoming target of transforming ...
PURPOSE: This single-institution Phase III study conducted from 1989 to 1995 evaluates the feasibility of a multimodality protocol combining hyperfractionated craniospinal radiotherapy (HFRT) followed by adjuvant chemotherapy in 23 patients with newly diagnosed primitive neuroectodermal tumors (PNET) arising in the central nervous system. METHODS AND MATERIALS: All 23 patients had a histologically confirmed PNET and were over 3 years of age at diagnosis. The eligibility criteria for PNET patients with cerebellar primaries (medulloblastoma) included either a high T stage (T3b or 4) or high M stage (M1-3). All patients with noncerebellar primaries were eligible regardless of T or M stage. The median age of the 23 patients was 9 years (mean 3-25); 11 were female. The primary tumor arose in the cerebellum in 19. Of these medulloblastoma patients, 15 had high T stages (T3b or T4) with large locally invasive tumors and no evidence of metastases (M0), constituting Group 1. Thirteen (86%) of these ...
Glioblastomas are the most common malignant brain tumors in adults, and they are notoriously difficult to treat successfully. "The survival with glioblastoma is usually a year on average, and that hasn t improved in a while, so this is a very serious and challenging disease," says Paul Mischel, M.D., of the David Geffen School of Medicine and Jonsson Comprehensive Cancer Center at the University of California, Los Angeles (UCLA), who led the study. While drugs are available to help treat glioblastoma, they often have minimal effect, and doctors usually have time to try only one or two treatments before the disease causes severe impairment. Glioblastomas feature many genetic variations that affect their response to different treatments. Researchers are trying to identify these genetic factors and to tease apart how they affect the disease in order to determine which patients are the most likely to benefit from specific drugs ...
Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy Jicai Zhang, Xiang Xiao, Jianming Zhu, Ziyun Gao, Xianliang Lai, Xingen Zhu, Guohua Mao Department of Neurosurgery, Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China Purpose: Glioblastoma multiforme (GBM) is the most common malignant brain tumor originating in the central nervous system in adults. Based on nanotechnology such as liposomes, polymeric nanoparticles, and lipid nanoparticles, recent research efforts have been aimed to target drugs to the brain. Methods: In this study, lactoferrin- and arginine–glycine–aspartic acid (RGD) dual-ligand-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers (L/R-T/V-NLCs) were introduced for GBM combination therapy. The physicochemical properties of L/R-T/V-NLCs such as particle size, zeta potential, and encapsulated efficiency are measured. The drug
Pediatric brain cancer is one of the most common forms of disease diagnosed in children. Market Research Future, a firm which specializes in market reports related to the healthcare sector among others, published in its recent report on Pediatric Brain Tumor Market Research Report - Global Forecast till 2023, that the global pediatric brain tumor market is growing at the CAGR of 4.1% during the forecast period and expected to reach US$ 1659.4 million by 2023. Increasing incidences of pediatric brain tumor are being identified around the world which has contributed gradually to the growth of the market.. The main causative factor for pediatric brain tumor market is genetics. Most of the tumors are diagnosed after child birth till 12 years of age, which is usually detected after appearance of certain symptoms. Due to the appearance of additional types of mutations in terms of pediatric brain tumor, the scope of the market has widened significantly. Most of the tumors currently known in this ...
Abstract BACKGROUND: Primitive neuroectodermal tumors (PNETs) comprise a group of aggressive, poorly differentiated embryonal tumors occurring in central nervous system as well as in peripheral locations. Primary cerebellopontine angle (CPA) PNET is an extremely rare entity. It is important to have knowledge of this pathology and to be able to differentiate it from other commonly occurring CPA tumors, such as vestibular and trigeminal schwannomas. This distinction is essential because of the difference in the overall treatment plan and prognosis. CASE DESCRIPTION: This report describes a case of a young male presenting with diplopia and numbness of face; magnetic resonance imaging showed a CPA mass. With a provisional diagnosis of trigeminal schwannoma, the patient underwent surgery. Histopathology provided a diagnosis of PNET. CONCLUSION: We discuss the importance of recognizing this rare condition and how this entity differs from the commonly occurring tumors.
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin-Goltz syndrome is characterized by basal cell carcinoma (BCC), odontogenic keratocy..
• A patient with the nevoid basal cell carcinoma syndrome had been treated with radiation therapy to the hands at 5 years of age. Multiple basal cell carcinomas
von Hippel-Lindau syndrome. Sagittal vertebral angiogram of the same patient as in the previous 3 images shows a hypervascular intramural nodule (open arrow) that demonstrates a prolonged and intense enhancement with a surrounding avascular area, representing the cyst surrounding the mural nodule (solid arrows). Note the stretching of vessels around the cyst. The final diagnosis was a cerebellar hemangioblastoma associated with von Hippel-Lindau syndrome (same patient as in Images 1-3).VHL is characterized by a predisposition to bilateral and multicentric retinal angiomas, central nervous system (CNS) hemangioblastomas; renal cell carcinomas; pheochromocytoma s; islet cell tumors of the pancreas; endolymphatic sac tumors[1] ; and renal, pancreatic, and epididymal cysts.[2, 3] CNS hemangioblastoma (Lindau tumor) is the most commonly recognized manifestation of VHL and occurs in 40% of patients.[4] ...
Some late effects may be treated or controlled. It is important to talk with your childs doctors about the effects cancer treatment can have on your child. (See the PDQ summary on Late Effects of Treatment for Childhood Cancer for more information).. Three types of standard treatment are used:. Surgery Surgery is used to diagnose and treat childhood supratentorial primitive neuroectodermal tumors and pineoblastoma as described in the General Information section of this summary. Radiation therapy Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. The way the radiation therapy is given depends on the type and stage of ...
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome or Basal Cell Nevus Syndrome (BCNS), is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms. It is caused by mutations in the PTCH1 gene and is transmitted as an autosomal dominant trait with complete penetrance and variable expressivity.. The estimated prevalence varies from 1/57,000 to 1/256,000, with a male-to-female ratio of 1:1.. Main clinical manifestations include multiple basal cell carcinomas (BCCs), odontogenic keratocysts of the jaws, hyperkeratosis of palms and soles, skeletal abnormalities, intracranial ectopic calcifications, and facial dysmorphism (macrocephaly, cleft lip/palate and severe eye anomalies). Intellectual deficit is present in up to 5% of cases.. BCCs are a prominent feature of BCNS and occur at an earlier age than sporadic BCCs. BCCs may arise in various stages of the syndrome: most often they appear between puberty and 35 ...

Cerebellar Neoplasms; Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar NeoplasmsCerebellar Neoplasms; Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar Neoplasms

Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar Neoplasms. On-line free medical diagnosis assistant. ... Cerebellar Neoplasms (Benign Cerebellar Neoplasms; Cerebellar Cancer; Malignant Cerebellar Neoplasms). Primary or metastatic ... "Cerebellar Neoplasms"Drugs, active principles and "Cerebellar Neoplasms"Medicinal plantsQuestions and answers from other users ... Common primary cerebellar tumors include fibrillary astrocytoma and cerebellar hemangioblastoma. The cerebellum is a relatively ...
more infohttps://lookfordiagnosis.com/mesh_info.php?term=Cerebellar+Neoplasms&lang=1

Cerebellum Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsCerebellum Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary : Cerebellum Cancer, also known as cerebellar neoplasms, is related to cerebellar medulloblastoma and ... The transitory superficial granular layer of the cerebellar cortex; its relationship to certain cerebellar neoplasms. ( ... Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis. ( ... Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms. ( 21921669 ) ...
more infohttps://www.malacards.org/card/cerebellum_cancer

Basal Cell Nevus Syndrome (Gorlin Syndrome) | Cancer Genetics WebBasal Cell Nevus Syndrome (Gorlin Syndrome) | Cancer Genetics Web

Although cerebellar enlargement occurs in ptch1 heterozygous-deficient mice, its impact on human brain development remains ... Basaloid follicular hamartomas (BFHs) constitute rare neoplasms that can be detected in sporadic and familial settings as in ... 151.3 [8.7] mm, P = 0.0007) of the cerebrum, cross-sectional area of the cerebellar vermis (18.7 [2.6] vs. 11.8 [1.7] cm ... 11.6 [2.3] years old). The diameters of the cerebrum, corpus callosum, and brain stem and the cerebellar volume were compared ...
more infohttp://www.cancerindex.org/geneweb/gorlin_syndrome.htm

Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis.Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis.

Cerebellar Neoplasms / diagnosis*, genetics, pathology, surgery. Cerebellum / pathology, surgery. Child. Chromosome Deletion. ...
more infohttp://www.biomedsearch.com/nih/Cowden-disease-Lhermitte-Duclos-characterization/10690726.html

Search Results | jnsSearch Results | jns

Pediatric patients with cerebellar neoplasms found to have an RT2SI of less than or equal to 0.71 are recommended for neuraxis ... Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis Clinical ... The authors first reviewed the literature to gain an appreciation of the risk of LD of pediatric cerebellar neoplasms based on ... Of the 31 neoplasms retrospectively designated as hypointense T2-weighted lesions (RT2SI ≤ 0.71), 30 (97%) were Grade II or ...
more infohttps://thejns.org/search?f_0=author&q_0=Lola+Chambless

Distinct differences in binding capacity to saccharide epitopes in supratentorial pilocytic astrocytomas, astrocytomas,...Distinct differences in binding capacity to saccharide epitopes in supratentorial pilocytic astrocytomas, astrocytomas,...

Cerebellar Neoplasms (blood supply, metabolism) *Epitopes. *Female. *Forssman Antigen. *Fucose (immunology, metabolism) ...
more infohttp://www.curehunter.com/public/pubmed11202177.do

David Cochrans research topics | Profiles RNSDavid Cochran's research topics | Profiles RNS

Cerebellar Neoplasms. 1. 2007. 7. 0.110. Why? Medulloblastoma. 1. 2007. 11. 0.110 ...
more infohttps://profiles.umassmed.edu/display/132291/network/researchareas/details

Multipotent CD15+ Cancer Stem Cells in patched-1-deficient Mouse Medulloblastoma - PubMedMultipotent CD15+ Cancer Stem Cells in patched-1-deficient Mouse Medulloblastoma - PubMed

Cerebellar Neoplasms / pathology *. Actions. * Search in PubMed * Search in MeSH * Add to Search ...
more infohttps://pubmed.ncbi.nlm.nih.gov/19487286/

Modular organization of cerebellar climbing fiber inputs during goal-directed behavior.Modular organization of cerebellar climbing fiber inputs during goal-directed behavior.

Cerebellar Neoplasms. Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA ... Paraneoplastic Cerebellar Degeneration. Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations ... A Registered Cohort Study on Cerebellar Ataxia. Cerebellar ataxia is a form of ataxia originating in the cerebellum. Cerebellar ... The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2504195/Modular-organization-of-cerebellar-climbing-fiber-inputs-during-goal-directed-behavior.html

Hemangioblastoma | definition of hemangioblastoma by Medical dictionaryHemangioblastoma | definition of hemangioblastoma by Medical dictionary

2) A vascularised cerebellar tumour, representing 2% of CNS neoplasms, which occurs in the 3rd-4th decades, either alone or ... A benign cerebellar neoplasm composed of capillary vessel-forming endothelial cells and stromal cells; a slowly growing tumor ... cerebellar hemangioblastoma hemangioblastoma of the cerebellum, often cystic; an autosomal dominant form is associated with von ... A benign neoplasm frequently arising in the cerebellum composed of capillary vessel-forming endothelial cells and stromal cells ...
more infohttps://medical-dictionary.thefreedictionary.com/hemangioblastoma

Department of Neurosurgery - Research Output
     - Penn StateDepartment of Neurosurgery - Research Output - Penn State

Harbaugh, R. E., Reeder, T. M., Senter, H. J., Knopman, D. S., Baskin, D. S., Pirozzolo, F., Chui, H. C., Shetter, A. G., Bakay, R. A. E., Leblanc, R., Watson, R. T., DeKosky, S. T., Schmitt, F. A., Read, S. L. & Johnston, J. T., Jan 1 1989, In : Journal of neurosurgery. 71, 4, p. 481-486 6 p.. Research output: Contribution to journal › Article ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/department-of-neurosurgery-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=publicationYearThenTitle&descending=false&page=2

metastatic malignant neoplasm to the spinal cord drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginemetastatic malignant neoplasm to the spinal cord drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

Cerebellar Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Medulloblastoma / drug therapy. Neoplasm Recurrence, ... Lung Neoplasms / pathology. Spinal Cord Neoplasms / secondary. *[MeSH-minor] Brain Neoplasms / secondary. Brain Neoplasms / ... Neoplasm Recurrence, Local. Ovarian Neoplasms / pathology. Spinal Cord Neoplasms / secondary. *[MeSH-minor] Abdominal Neoplasms ... Lung Neoplasms / pathology. Spinal Cord Neoplasms / secondary. *[MeSH-minor] Adult. Brain Neoplasms / secondary. Fatal Outcome ...
more infohttp://www.bmlsearch.com/?kwr=metastatic+malignant+neoplasm+to+the+spinal+cord+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

colon nos polyp adenomatous drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginecolon nos polyp adenomatous drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Cerebellar Neoplasms / genetics. Colonic Neoplasms / genetics. DNA-Binding Proteins / genetics. Leukemia, Myeloid, ... Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology. *MedlinePlus Health Information. consumer health - Cancer ... Colorectal Neoplasms / prevention & control. Colorectal Neoplasms, Hereditary Nonpolyposis / drug therapy. Starch / therapeutic ... Colonic Neoplasms / pathology. *[MeSH-minor] Adenoma / chemistry. Adenoma / pathology. Biomarkers / analysis. Cell Cycle. ...
more infohttp://www.bmlsearch.com/?kwr=colon+nos+polyp+adenomatous+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

Alfredo Quinones-Hinojosa, MD - Research Output
     - Mayo ClinicAlfredo Quinones-Hinojosa, MD - Research Output - Mayo Clinic

Cerebellar Neoplasms Unusual venous drainage of an arteriovenous malformation: Case illustration. Quinones-Hinojosa, A., ... A choroid plexus tumor of the lateral ventricle mimicking a cerebellar lesion. Pendleton, C., Olivi, A., Jallo, G. I. & ...
more infohttps://mayoclinic.pure.elsevier.com/en/persons/alfredo-quinones-hinojosa/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=type&descending=false&page=6

Angioblastomata | definition of angioblastomata by Medical dictionaryAngioblastomata | definition of angioblastomata by Medical dictionary

A benign cerebellar neoplasm composed of capillary vessel-forming endothelial cells and stromal cells; a slowly growing tumor ... A benign neoplasm frequently arising in the cerebellum composed of capillary vessel-forming endothelial cells and stromal cells ...
more infohttps://medical-dictionary.thefreedictionary.com/angioblastomata

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.

Cerebellar Neoplasms. Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA ... Paraneoplastic Cerebellar Degeneration. Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations ... A Registered Cohort Study on Cerebellar Ataxia. Cerebellar ataxia is a form of ataxia originating in the cerebellum. Cerebellar ... The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2589019/TTBK2-and-primary-cilia-are-essential-for-the-connectivity-and-survival-of.html

Apparent Diffusion Coefficients for Differentiation of Cerebellar Tumors in Children | American Journal of NeuroradiologyApparent Diffusion Coefficients for Differentiation of Cerebellar Tumors in Children | American Journal of Neuroradiology

ADC values and ratios are simple and readily available techniques for evaluation of pediatric cerebellar neoplasms that may ... Accurate preoperative diagnosis is an important goal in pediatric patients with cerebellar neoplasms, because the most common ... Histologic diagnosis and MR imaging studies were evaluated for all pediatric patients with cerebellar neoplasm. Histologic ... Fifteen-year-old girl with cerebellar JPA (patient 5). ADC map in axial plane at level of middle cerebellar peduncles shows ...
more infohttp://www.ajnr.org/content/27/6/1362

Department of Neurosurgery - Research Output
     - The University of Tennessee Health Science CenterDepartment of Neurosurgery - Research Output - The University of Tennessee Health Science Center

Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features. Choudhri, A., ... Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features. Choudhri, A., ...
more infohttps://uthsc.pure.elsevier.com/en/organisations/department-of-neurosurgery-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fsystematicreview

SHENANDOAH ROBINSON | Researcher Profile | Symptoma.comSHENANDOAH ROBINSON | Researcher Profile | Symptoma.com

Cerebellar Neoplasms ❗ Translocation, Genetic ❗ Hypoxia-Ischemia, Brain ❗ Glioblastoma ❗ Check More at Symptoma.com ... Cerebellar Neoplasms 75x. Translocation, Genetic 68x. Hypoxia-Ischemia, Brain 41x. Glioblastoma 38x. Brain Neoplasms ...
more infohttps://www.symptoma.com/en/research/profile/s_robinson_2

Formats: Text / Collections: Medicine in the Americas, 1610-1920 / Genre: Addresses and Case Reports - Digital Collections -...Formats: Text / Collections: Medicine in the Americas, 1610-1920 / Genre: Addresses and Case Reports - Digital Collections -...

Cerebellar Neoplasms -- pathology. 30. On masturbation and hysteria in young children Author(s):. Jacobi, A. (Abraham), 1830- ... Head and Neck Neoplasms -- therapy. Breast Neoplasms -- therapy. Rectal Neoplasms -- therapy. United States. 60. Concussion of ... Neoplasms -- diagnosis. Early Detection of Cancer. Boston. 69. Importance of the early recognition of epilepsy: an essay read ... Pancreatic Neoplasms -- diagnosis. Georgia. 15. Nervous shock and disease of the nervous system as a cause of pernicious anemia ...
more infohttps://collections.nlm.nih.gov/?f%5Bdrep2.format%5D%5B%5D=Text&f%5Bdrep2.isMemberOfCollection%5D%5B%5D=DREPMIA&f%5Bdrep2.subjectGenre%5D%5B%5D=Addresses&f%5Bdrep2.subjectGenre%5D%5B%5D=Case+Reports&page=1&per_page=100

Case #21190
 | Neurology Image Library | Internet Stroke CenterCase #21190 | Neurology Image Library | Internet Stroke Center

Neoplasm: Cerebellar tumor; Hydrocephalus, obstructive. * Head MR. Initial Scan - 23 series * T1 - Sagittal ...
more infohttp://www.strokecenter.org/radiology/patients/21190/studies/1870/series/5603

Neurology Image Library | Internet Stroke CenterNeurology Image Library | Internet Stroke Center

Neoplasm: Cerebellar tumor; Hydrocephalus, obstructive. MR. 8360. 40. F. Dissection, vertebral artery (L); Systemic lupus ... Neoplasm: Glioma, thalamus (L). CT. 17327. 50. M. Neoplasm: Glial tumor, leptomeningeal involvement, temporal lobe (R) and T11 ... Infarct, posterior inferior cerebellar artery, acute (L); Infarct, middle cerebral artery, old (L); Infarct, anterior cerebral ...
more infohttp://www.strokecenter.org/radiology/patients?page=8

Code System ConceptCode System Concept

Cerebellar neoplasm sample (specimen). Code System Preferred Concept Name. Cerebellar neoplasm sample (specimen). ... Brain neoplasm tissue sample (specimen) {16210891000119102 , SNOMED-CT } Specimen from cerebellum (specimen) {443498007 , ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=16210851000119107
  • Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells. (nih.gov)
  • Brain MR imaging studies that included ADC maps were retrospectively reviewed in 32 patients with histologically proved cerebellar neoplasm. (ajnr.org)
  • 2) A vascularised cerebellar tumour, representing 2% of CNS neoplasms, which occurs in the 3rd-4th decades, either alone or associated with von-Hippel-Lindau syndrome, phaeochromocytoma, syringomyelia or erythrocythemia. (thefreedictionary.com)
  • Bioinformatic analysis of Mtss1 suggests that differential exon usage may affect interaction with Fyn and Src, two tyrosine kinases previously recognized as critical for cerebellar cell migration and histogenesis. (nih.gov)
  • Cerebellar granule cells, or their precursors, have been identified as a cellular origin of medulloblastomas. (nih.gov)
  • Retrospective review of patient records with histologically proved neoplasm in an electronic data base and PACS was performed in 2 institutions. (ajnr.org)